Stem definition | Drug id | CAS RN |
---|---|---|
diuretics, sulfamoylbenzoic acid derivatives | 1500 | 7492-32-2 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 9, 1957 | FDA | GLAXOSMITHKLINE |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | A03AB09 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, quaternary ammonium compounds |
ATC | A03CA01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS Synthetic anticholinergic agents in combination with psycholeptics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Peptic ulcer | indication | 13200003 | DOID:750 |
Brain damage | contraindication | 2470005 | |
Tachyarrhythmia | contraindication | 6285003 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Organophosphate poisoning | contraindication | 8260003 | |
Weight gain finding | contraindication | 8943002 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Orthostatic hypotension | contraindication | 28651003 | |
Atony of colon | contraindication | 29479008 | |
Torsades de pointes | contraindication | 31722008 | |
Parkinsonism | contraindication | 32798002 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Conduction disorder of the heart | contraindication | 44808001 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Extrapyramidal disease | contraindication | 76349003 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Stupor | contraindication | 89458003 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Tardive dyskinesia | contraindication | 102449007 | |
Prolonged QT interval | contraindication | 111975006 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Angina pectoris | contraindication | 194828000 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Drowsy | contraindication | 271782001 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Visual impairment | contraindication | 397540003 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Congenital long QT syndrome | contraindication | 442917000 | |
Carcinoma of female breast | contraindication | 447782002 |
Species | Use | Relation |
---|---|---|
Cats | Gastrointestinal disturbances associated with emotional stress | Indication |
Dogs | Gastrointestinal disturbances associated with emotional stress | Indication |
Product | Applicant | Ingredients |
---|---|---|
Darbazine Spansule Capsule No.1 | Zoetis Inc. | 2 |
Darbazine Injectable | Zoetis Inc. | 2 |
Neo-Darbazine Spansule Capsule No.1, Neo-Darbazine Spansule Capsule No.3 | Zoetis Inc. | 3 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M1 | GPCR | ANTAGONIST | CHEMBL | CHEMBL | |||||
Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
4022168 | VUID |
N0000020174 | NUI |
D01005 | KEGG_DRUG |
16564-41-3 | SECONDARY_CAS_RN |
4018003 | VANDF |
4020223 | VANDF |
4022168 | VANDF |
C0301373 | UMLSCUI |
CHEBI:6043 | CHEBI |
CHEMBL1201232 | ChEMBL_ID |
DB01625 | DRUGBANK_ID |
3775 | PUBCHEM_CID |
C084831 | MESH_SUPPLEMENTAL_RECORD_UI |
71-81-8 | SECONDARY_CAS_RN |
8B9I31H724 | UNII |
6051 | RXNORM |
NOCODE | MMSL |
001739 | NDDF |
004696 | NDDF |
20468007 | SNOMEDCT_US |
34657002 | SNOMEDCT_US |
398755007 | SNOMEDCT_US |
CHEMBL1200347 | ChEMBL_ID |
715 | INN_ID |
None