phenylalanine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2144	63-91-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: L-Phenylalanine phenylalanine	An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. Molecular weight: 165.19 Formula: C9H11NO2 CLOGP: -1.56 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 63.32 ALOGS: -1.60 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

L-Phenylalanine
phenylalanine

An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.

Molecular weight: 165.19
Formula: C9H11NO2
CLOGP: -1.56
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 63.32
ALOGS: -1.60
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal growth restriction	68.71	37.45	15	396	6552	46679099
Infantile apnoea	48.61	37.45	8	403	768	46684883
Selective eating disorder	42.14	37.45	8	403	1737	46683914

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:50733	nutritional supplement
CHEBI has role	CHEBI:63332	alkaline phosphatase inhibitors
CHEBI has role	CHEBI:75771	mus musculus metabolite
CHEBI has role	CHEBI:75772	baker's yeast metabolite
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
CHEBI has role	CHEBI:76971	e.coli metabolites
CHEBI has role	CHEBI:84735	algal metabolites
CHEBI has role	CHEBI:83056	daphnia magna metabolites

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Classical phenylketonuria	contraindication	7573000
Poisoning by digitalis glycoside	contraindication	12876009
Sarcoidosis	contraindication	31541009	DOID:11335
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Heart disease	contraindication	56265001	DOID:114
Hypercalcemia	contraindication	66931009	DOID:12678
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.27	acidic
pKa2	9.25	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Probable G-protein coupled receptor 139	Unclassified	Q6DWJ6	GP139_HUMAN	AGONIST	IC50	4.51	IUPHAR
Voltage-dependent calcium channel subunit alpha-2/delta-1	Ion channel		CA2D1_MOUSE		Ki	6.01	CHEMBL
Intestinal alkaline phosphatase	Unclassified		PPBI_BOVIN		IC50	4.10	CHEMBL
L-type amino acid transporter 1	Unclassified		LAT1_RAT		Ki	4.26	CHEMBL

External reference:

ID	Source
4018673	VUID
N0000146984	NUI
4018673	VANDF
C0031453	UMLSCUI
CHEBI:17295	CHEBI
PHE	PDB_CHEM_ID
CHEMBL301523	ChEMBL_ID
D010649	MESH_DESCRIPTOR_UI
DB00120	DRUGBANK_ID
3313	IUPHAR_LIGAND_ID
6168	INN_ID
47E5O17Y3R	UNII
6140	PUBCHEM_CID
8156	RXNORM
NOCODE	MMSL
003542	NDDF
421626005	SNOMEDCT_US
63004003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ProcalAmine	HUMAN PRESCRIPTION DRUG LABEL	22	0264-1915	INJECTION	0.17 g	INTRAVENOUS	NDA	24 sections
TrophAmine	HUMAN PRESCRIPTION DRUG LABEL	20	0264-1933	SOLUTION	0.48 g	INTRAVENOUS	NDA	23 sections
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-3200	SOLUTION	1.04 g	INTRAVENOUS	ANDA	20 sections
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-3205	SOLUTION	1.04 g	INTRAVENOUS	ANDA	20 sections
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-4500	SOLUTION	1.04 g	INTRAVENOUS	ANDA	20 sections
FreAmine III	HUMAN PRESCRIPTION DRUG LABEL	16	0264-9010	INJECTION, SOLUTION	0.56 g	INTRAVENOUS	NDA	24 sections
FreAmine III	HUMAN PRESCRIPTION DRUG LABEL	16	0264-9011	INJECTION, SOLUTION	0.56 g	INTRAVENOUS	NDA	24 sections
TrophAmine	HUMAN PRESCRIPTION DRUG LABEL	20	0264-9341	SOLUTION	0.48 g	INTRAVENOUS	NDA	23 sections
FreAmine HBC	HUMAN PRESCRIPTION DRUG LABEL	15	0264-9350	INJECTION, SOLUTION	0.32 g	INTRAVENOUS	NDA	24 sections
TrophAmine	HUMAN PRESCRIPTION DRUG LABEL	20	0264-9361	SOLUTION	0.29 g	INTRAVENOUS	NDA	23 sections
HepatAmine	HUMAN PRESCRIPTION DRUG LABEL	16	0264-9371	INJECTION, SOLUTION	0.10 g	INTRAVENOUS	NDA	23 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0180	INJECTION	448 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0184	INJECTION, EMULSION	448 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0188	INJECTION	448 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0194	INJECTION	448 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0198	INJECTION	336 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-0202	INJECTION	448 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-0206	INJECTION	448 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-0210	INJECTION	448 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-0214	INJECTION	448 mg	INTRAVENOUS	NDA	20 sections
ProSol	HUMAN PRESCRIPTION DRUG LABEL	17	0338-0499	INJECTION, SOLUTION	1 g	INTRAVENOUS	NDA	21 sections
Clinisol	HUMAN PRESCRIPTION DRUG LABEL	17	0338-0502	INJECTION, SOLUTION	1.04 g	INTRAVENOUS	ANDA	18 sections
Travasol	HUMAN PRESCRIPTION DRUG LABEL	15	0338-0644	INJECTION	560 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1089	INJECTION	238 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1091	INJECTION	238 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1099	INJECTION	280 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1101	INJECTION	280 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1113	INJECTION	238 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1115	INJECTION	238 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1123	INJECTION	280 mg	INTRAVENOUS	NDA	20 sections