ondansetron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
serotonin receptor antagonists (5-HT3) 1992 99614-02-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • GR-38032F
  • GR38032F
  • ondansetron
  • ondansetron hydrochloride
  • ondansetron hydrochloride dihydrate
  • ondansetron HCl
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
  • Molecular weight: 293.37
  • Formula: C18H19N3O
  • CLOGP: 2.72
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 39.82
  • ALOGS: -3.07
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
16 mg O
16 mg P
16 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 32 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.17 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 62 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.27 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 4, 1991 FDA NOVARTIS PHARMS CORP
Feb. 25, 2022 PMDA Maruishi Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1896.90 9.54 2468 295907 155881 90174191
Pemphigus 1051.68 9.54 4 298371 326860 90003212
Nausea 1042.39 9.54 6719 291656 1103597 89226475
Synovitis 983.69 9.54 21 298354 329731 90000341
Systemic lupus erythematosus 902.90 9.54 78 298297 361818 89968254
Hand deformity 895.49 9.54 16 298359 296346 90033726
Arthropathy 797.15 9.54 126 298249 366116 89963956
Constipation 792.20 9.54 2371 296004 278024 90052048
Drug ineffective 773.51 9.54 2188 296187 1382110 88947962
Glossodynia 769.18 9.54 82 298293 321697 90008375
Anti-cyclic citrullinated peptide antibody positive 754.33 9.54 4 298371 236429 90093643
Pericarditis 752.26 9.54 32 298343 270119 90059953
Vomiting 711.48 9.54 4729 293646 783564 89546508
Duodenal ulcer perforation 685.32 9.54 8 298367 221280 90108792
Wound 671.15 9.54 99 298276 302881 90027191
Helicobacter infection 631.09 9.54 27 298348 226823 90103249
Therapeutic product effect decreased 584.93 9.54 104 298271 277467 90052605
Folliculitis 562.90 9.54 26 298349 204327 90125745
Diarrhoea 547.90 9.54 5094 293281 934096 89395976
Impaired healing 541.20 9.54 67 298308 234132 90095940
Muscle injury 539.86 9.54 8 298367 176646 90153426
Rheumatic fever 486.17 9.54 3 298372 153118 90176954
Swelling 472.52 9.54 411 297964 418647 89911425
Type 2 diabetes mellitus 472.38 9.54 57 298318 203187 90126885
Neutropenia 464.13 9.54 1711 296664 223193 90106879
Thrombocytopenia 451.06 9.54 1612 296763 207113 90122959
Joint swelling 450.41 9.54 599 297776 502701 89827371
Dehydration 448.95 9.54 1535 296840 192912 90137160
Mobility decreased 439.65 9.54 139 298236 250595 90079477
Psoriatic arthropathy 427.20 9.54 112 298263 228223 90101849
Blood cholesterol increased 410.76 9.54 91 298284 207921 90122151
Contraindicated product administered 399.88 9.54 283 298092 319856 90010216
Irritable bowel syndrome 399.19 9.54 96 298279 207352 90122720
Death 391.70 9.54 2708 295667 453843 89876229
Sleep disorder due to general medical condition, insomnia type 388.27 9.54 7 298368 128687 90201385
Musculoskeletal stiffness 382.51 9.54 253 298122 296279 90033793
Liver injury 365.57 9.54 61 298314 170506 90159566
Neuropathy peripheral 358.85 9.54 1129 297246 135841 90194231
Drug intolerance 356.00 9.54 578 297797 447013 89883059
Joint range of motion decreased 344.12 9.54 27 298348 135616 90194456
Treatment failure 343.70 9.54 297 298078 303631 90026441
Fibromyalgia 339.68 9.54 127 298248 206142 90123930
C-reactive protein abnormal 338.93 9.54 20 298355 127409 90202663
Mucosal inflammation 334.36 9.54 645 297730 56980 90273092
Disease progression 325.83 9.54 1195 297180 155420 90174652
Lower respiratory tract infection 313.68 9.54 221 298154 250438 90079634
Blister 307.20 9.54 234 298141 254764 90075308
Abdominal discomfort 303.45 9.54 704 297671 476624 89853448
White blood cell count decreased 303.30 9.54 1221 297154 165888 90164184
Arthralgia 302.58 9.54 1427 296948 777095 89552977
Torsade de pointes 296.72 9.54 305 298070 14877 90315195
Facet joint syndrome 294.16 9.54 6 298369 98383 90231689
Serotonin syndrome 283.74 9.54 474 297901 37413 90292659
Inflammation 272.91 9.54 123 298252 178469 90151603
Ill-defined disorder 272.28 9.54 134 298241 184757 90145315
Osteoarthritis 267.52 9.54 156 298219 195574 90134498
Breast cancer stage III 257.18 9.54 4 298371 84443 90245629
Discomfort 256.96 9.54 315 298060 274020 90056052
Electrocardiogram QT prolonged 256.65 9.54 666 297709 71790 90258282
Hypercholesterolaemia 256.13 9.54 20 298355 100872 90229200
Therapeutic product effect incomplete 253.22 9.54 163 298212 193733 90136339
Hypoxia 251.86 9.54 661 297714 71738 90258334
Lip dry 250.80 9.54 22 298353 100933 90229139
Condition aggravated 250.14 9.54 1060 297315 594485 89735587
Abdominal pain 248.96 9.54 2185 296190 393536 89936536
Pulmonary fibrosis 238.12 9.54 35 298340 107468 90222604
Fatigue 236.50 9.54 5206 293169 1148817 89181255
Plasma cell myeloma 229.53 9.54 451 297924 40377 90289695
Hepatic enzyme increased 226.72 9.54 535 297840 360201 89969871
Grip strength decreased 225.09 9.54 22 298353 92554 90237518
Peripheral venous disease 220.65 9.54 14 298361 83907 90246165
Cytokine release syndrome 220.27 9.54 358 298017 27615 90302457
Emotional distress 215.89 9.54 413 297962 36249 90293823
Aplastic anaemia 214.33 9.54 241 298134 13028 90317044
Erythema 208.78 9.54 1381 296994 227865 90102207
Gait inability 206.91 9.54 112 298263 146344 90183728
Wheezing 206.89 9.54 289 298086 237791 90092281
Pyrexia 206.02 9.54 3183 295192 657302 89672770
Food allergy 205.98 9.54 330 298045 25148 90304924
Wound infection 205.08 9.54 49 298326 106353 90223719
Sepsis 203.48 9.54 1146 297229 178668 90151404
Alopecia 201.73 9.54 891 297484 494180 89835892
Flushing 199.99 9.54 694 297681 87797 90242275
Back pain 198.66 9.54 1750 296625 315425 90014647
Weight increased 187.77 9.54 724 297651 417203 89912869
Red blood cell sedimentation rate increased 187.36 9.54 25 298350 82570 90247502
Neutropenic sepsis 183.83 9.54 261 298114 17869 90312203
Anaemia 174.35 9.54 1852 296523 350950 89979122
Hyperhidrosis 174.03 9.54 898 297477 135407 90194665
Drug abuse 172.98 9.54 31 298344 82316 90247756
Sleep disorder 167.46 9.54 245 298130 197785 90132287
Neutrophil count decreased 166.87 9.54 567 297808 70965 90259107
Drug hypersensitivity 165.76 9.54 874 297501 462735 89867337
Rheumatoid arthritis 163.60 9.54 627 297748 361987 89968085
Bone erosion 159.42 9.54 3 298372 53018 90277054
Hip arthroplasty 159.41 9.54 29 298346 76179 90253893
Knee arthroplasty 157.00 9.54 40 298335 83142 90246930
Sciatica 154.56 9.54 70 298305 101312 90228760
Adjustment disorder with depressed mood 153.69 9.54 8 298367 56745 90273327
Platelet count decreased 152.30 9.54 869 297506 136100 90193972
Lower limb fracture 150.92 9.54 46 298329 84967 90245105
Cardiac arrest 147.86 9.54 711 297664 104224 90225848
Hospice care 147.84 9.54 171 298204 9533 90320539
Obesity 147.10 9.54 82 298293 105425 90224647
Musculoskeletal pain 146.62 9.54 210 298165 171041 90159031
Chills 144.55 9.54 834 297541 131147 90198925
Febrile bone marrow aplasia 144.02 9.54 169 298206 9569 90320503
Colitis 143.92 9.54 532 297843 69410 90260662
Decreased appetite 142.82 9.54 1879 296496 374661 89955411
Lung disorder 141.41 9.54 171 298204 149712 90180360
Small intestinal obstruction 138.53 9.54 250 298125 20984 90309088
Temperature regulation disorder 137.77 9.54 203 298172 14376 90315696
Chest discomfort 135.99 9.54 850 297525 137515 90192557
Gangrene 135.95 9.54 189 298186 12687 90317385
Encephalopathy 135.74 9.54 398 297977 46046 90284026
General physical health deterioration 134.51 9.54 656 297719 354459 89975613
Foetal death 133.94 9.54 243 298132 20480 90309592
Hypokalaemia 131.70 9.54 810 297565 130306 90199766
Urinary tract infection 131.21 9.54 1561 296814 304071 90026001
X-ray abnormal 131.10 9.54 4 298371 45420 90284652
Autoimmune disorder 128.38 9.54 46 298329 76698 90253374
Dysphagia 127.88 9.54 717 297658 111561 90218511
Pancytopenia 127.18 9.54 753 297622 119510 90210562
Malignant neoplasm progression 125.40 9.54 688 297687 106182 90223890
Eating disorder 123.95 9.54 281 298094 27792 90302280
Arterial occlusive disease 120.07 9.54 175 298200 12271 90317801
Intentional product use issue 119.06 9.54 344 298031 216548 90113524
Carotid artery thrombosis 118.50 9.54 148 298227 8944 90321128
Blepharospasm 118.36 9.54 20 298355 55425 90274647
Retching 117.96 9.54 220 298155 18939 90311133
Full blood count decreased 117.79 9.54 285 298090 29404 90300668
Peripheral swelling 117.68 9.54 836 297539 412270 89917802
Osteoporosis 116.90 9.54 88 298287 96443 90233629
Foot deformity 115.86 9.54 27 298348 59624 90270448
C-reactive protein increased 115.44 9.54 267 298108 181122 90148950
Lupus-like syndrome 115.15 9.54 13 298362 48833 90281239
Ventricular tachycardia 113.21 9.54 251 298124 24457 90305615
Asthenia 112.75 9.54 2421 295954 531330 89798742
Neurologic neglect syndrome 112.10 9.54 142 298233 8705 90321367
Anaphylactic reaction 111.24 9.54 576 297799 86948 90243124
Immunodeficiency 110.94 9.54 354 298021 42880 90287192
Adjustment disorder 110.08 9.54 147 298228 9495 90320577
Rash erythematous 108.80 9.54 464 297911 64640 90265432
Loss of personal independence in daily activities 107.75 9.54 176 298199 135929 90194143
Liver disorder 107.50 9.54 145 298230 121124 90208948
Nasopharyngitis 107.30 9.54 842 297533 406262 89923810
Hypotension 107.21 9.54 1584 296791 323813 90006259
Tachycardia 107.00 9.54 886 297489 156787 90173285
Pleural effusion 106.94 9.54 683 297692 111308 90218764
Aphasia 106.64 9.54 347 298028 42465 90287607
Anaphylactic shock 106.20 9.54 285 298090 31332 90298740
Neoplasm progression 105.84 9.54 355 298020 44131 90285941
Road traffic accident 105.59 9.54 119 298256 107507 90222565
Prescribed underdose 103.57 9.54 59 298316 74960 90255112
Exostosis 103.30 9.54 24 298351 53110 90276962
Transfusion 101.71 9.54 196 298179 17292 90312780
Ventricular fibrillation 101.54 9.54 173 298202 13871 90316201
Contusion 98.61 9.54 458 297917 250758 90079314
Left-to-right cardiac shunt 96.61 9.54 36 298339 246 90329826
Medication error 95.23 9.54 83 298292 84569 90245503
Oculogyric crisis 95.11 9.54 73 298302 2406 90327666
Heart disease congenital 94.43 9.54 62 298313 1587 90328485
Delirium 93.29 9.54 124 298251 104235 90225837
Oedema 93.05 9.54 342 298033 199953 90130119
Onychomadesis 93.03 9.54 19 298356 45979 90284093
Atelectasis 92.25 9.54 230 298145 24179 90305893
Laryngospasm 91.90 9.54 81 298294 3252 90326820
Live birth 90.90 9.54 76 298299 79031 90251041
Intestinal obstruction 90.73 9.54 299 298076 36832 90293240
Night sweats 88.99 9.54 181 298194 128585 90201487
Palmar-plantar erythrodysaesthesia syndrome 87.56 9.54 246 298129 27777 90302295
Hereditary angioedema 86.48 9.54 129 298246 9236 90320836
Dystonia 86.42 9.54 179 298196 16640 90313432
Joint stiffness 86.01 9.54 78 298297 77964 90252108
Drug tolerance decreased 85.54 9.54 5 298370 32125 90297947
Unresponsive to stimuli 83.53 9.54 296 298079 37825 90292247
Long QT syndrome 82.34 9.54 83 298292 3954 90326118
Finger deformity 82.15 9.54 7 298368 32890 90297182
Toxicity to various agents 81.18 9.54 584 297791 287262 90042810
Sensory loss 80.99 9.54 182 298193 17893 90312179
Macular degeneration 80.38 9.54 14 298361 37956 90292116
Injection site reaction 79.69 9.54 112 298263 91968 90238104
Motor dysfunction 78.87 9.54 187 298188 19043 90311029
Ascites 78.80 9.54 339 298036 47401 90282671
Bursitis 78.07 9.54 201 298174 131453 90198619
Personality disorder 77.99 9.54 144 298231 12300 90317772
Therapeutic response decreased 77.80 9.54 109 298266 89620 90240452
Joint dislocation 77.55 9.54 25 298350 44557 90285515
Intentional self-injury 76.79 9.54 5 298370 29329 90300743
Clonus 75.58 9.54 94 298281 5656 90324416
Adverse event 75.36 9.54 172 298203 117246 90212826
Nail disorder 75.24 9.54 51 298324 59016 90271056
Anxiety 75.20 9.54 1435 296940 308337 90021735
Hypomagnesaemia 75.13 9.54 273 298102 35315 90294757
Anhedonia 75.09 9.54 135 298240 11296 90318776
Computerised tomogram thorax abnormal 74.74 9.54 59 298316 2028 90328044
Onychomycosis 74.43 9.54 16 298359 37360 90292712
Cough 74.42 9.54 1663 296712 367299 89962773
Hemiplegia 73.85 9.54 164 298211 15996 90314076
Dysgeusia 73.19 9.54 355 298020 52205 90277867
Illness 71.63 9.54 489 297886 81480 90248592
Product dose omission issue 71.06 9.54 1352 297023 290335 90039737
Hepatic cirrhosis 68.77 9.54 64 298311 63189 90266883
Breast cancer stage II 68.61 9.54 16 298359 35318 90294754
Drug-induced liver injury 68.51 9.54 120 298255 90198 90239874
Vascular device infection 68.34 9.54 133 298242 11819 90318253
Affect lability 68.05 9.54 170 298205 17893 90312179
Leukopenia 67.27 9.54 564 297811 100146 90229926
Desmoplastic small round cell tumour 66.60 9.54 21 298354 79 90329993
Blood potassium decreased 66.20 9.54 322 298053 47405 90282667
Computerised tomogram thorax 66.06 9.54 33 298342 492 90329580
Clostridium difficile infection 65.00 9.54 264 298111 35981 90294091
Type I hypersensitivity 64.61 9.54 74 298301 4081 90325991
Epilepsy 64.40 9.54 107 298268 82099 90247973
Upper respiratory tract infection 64.35 9.54 676 297699 127642 90202430
Hair colour changes 64.34 9.54 68 298307 3426 90326646
Sinusitis 64.33 9.54 771 297604 342317 89987755
Bone pain 64.16 9.54 386 297989 61597 90268475
Pulmonary embolism 64.12 9.54 686 297689 130134 90199938
Back injury 63.88 9.54 37 298338 46585 90283487
Dry mouth 62.87 9.54 352 298023 183707 90146365
Carbohydrate antigen 125 increased 62.71 9.54 65 298310 3201 90326871
Device expulsion 62.66 9.54 28 298347 40858 90289214
Oxygen saturation decreased 62.53 9.54 584 297791 106899 90223173
Epistaxis 62.43 9.54 487 297888 84638 90245434
Skin haemorrhage 62.26 9.54 183 298192 21197 90308875
Impaired gastric emptying 61.95 9.54 133 298242 12676 90317396
Rash maculo-papular 61.77 9.54 283 298092 40650 90289422
Red blood cell count decreased 61.65 9.54 309 298066 46042 90284030
Sinus tachycardia 60.42 9.54 219 298156 28294 90301778
Urticaria 60.08 9.54 699 297676 312035 90018037
Dysarthria 60.08 9.54 345 298030 54137 90275935
Bronchospasm 60.06 9.54 177 298198 20532 90309540
Stomatitis 59.59 9.54 597 297778 274101 90055971
Product label confusion 59.50 9.54 4 298371 22846 90307226
Therapy non-responder 59.24 9.54 240 298135 136464 90193608
Hypoaesthesia 58.18 9.54 708 297667 313502 90016570
Walking aid user 58.17 9.54 22 298353 35484 90294588
Sinus congestion 56.73 9.54 209 298166 27215 90302857
Intentional overdose 55.06 9.54 144 298231 93690 90236382
Coordination abnormal 54.91 9.54 175 298200 21181 90308891
Dyspnoea 54.24 9.54 3476 294899 877479 89452593
Pregnancy 54.16 9.54 75 298300 61972 90268100
Laryngitis 53.26 9.54 53 298322 50700 90279372
Infusion related reaction 53.19 9.54 1009 297366 415771 89914301
Oral pain 53.11 9.54 231 298144 32452 90297620
Completed suicide 53.10 9.54 271 298104 144787 90185285
Product administration interrupted 52.89 9.54 123 298252 12369 90317703
Headache 52.53 9.54 3401 294974 859345 89470727
Skin exfoliation 52.29 9.54 393 297982 67520 90262552
Calcium ionised decreased 51.89 9.54 25 298350 343 90329729
Hemiparesis 51.78 9.54 225 298150 31594 90298478
Segmental diverticular colitis 51.63 9.54 20 298355 154 90329918
Sneezing 51.54 9.54 215 298160 29654 90300418
Opisthotonus 50.69 9.54 25 298350 362 90329710
Blood pressure diastolic abnormal 50.28 9.54 4 298371 19877 90310195
Product quality issue 50.25 9.54 117 298258 79208 90250864
Hydronephrosis 50.21 9.54 120 298255 12282 90317790
Acute respiratory failure 50.12 9.54 276 298099 42642 90287430
Injection site pain 50.11 9.54 350 298025 173349 90156723
Failure to thrive 49.81 9.54 95 298280 8316 90321756
Sinus disorder 48.92 9.54 234 298141 34213 90295859
Respiratory syncytial virus infection 48.61 9.54 107 298268 10373 90319699
Acute kidney injury 48.28 9.54 1389 296986 318998 90011074
Bacteraemia 47.86 9.54 172 298203 22128 90307944
Therapy interrupted 47.44 9.54 305 298070 49803 90280269
Porphyria acute 47.24 9.54 3 298372 17972 90312100
Dilatation intrahepatic duct acquired 46.74 9.54 30 298345 738 90329334
Pustular psoriasis 46.19 9.54 4 298371 18552 90311520
Injury 46.14 9.54 421 297954 196928 90133144
Mental status changes 46.08 9.54 278 298097 44401 90285671
Hypophagia 45.99 9.54 237 298138 35700 90294372
Rheumatoid nodule 45.98 9.54 6 298369 20160 90309912
Tracheal deviation 45.86 9.54 21 298354 255 90329817
Osteonecrosis of jaw 45.62 9.54 37 298338 39066 90291006
Enterocolitis 45.19 9.54 104 298271 10386 90319686
Gestational hypertension 45.05 9.54 53 298322 3009 90327063
Pneumonitis 45.03 9.54 274 298101 43896 90286176
Infection 44.54 9.54 882 297493 361212 89968860
Seizure 44.46 9.54 728 297647 151901 90178171
Haemoglobin decreased 44.44 9.54 765 297610 161191 90168881
Fluid retention 44.12 9.54 464 297911 87627 90242445
Maternal exposure timing unspecified 44.01 9.54 10 298365 22473 90307599
Gait disturbance 43.75 9.54 599 297776 259897 90070175
Drug resistance 43.40 9.54 23 298352 30426 90299646
Incorrect route of product administration 43.38 9.54 62 298313 50564 90279508
Injection site erythema 43.26 9.54 172 298203 98330 90231742
Thrombosis 43.10 9.54 399 297976 72852 90257220
Hypersensitivity 42.88 9.54 1154 297221 453523 89876549
Palpitations 42.78 9.54 660 297715 136068 90194004
Lupus vasculitis 42.67 9.54 26 298349 582 90329490
Electrocardiogram QRS complex 42.48 9.54 9 298366 0 90330072
Myocardial infarction 42.26 9.54 192 298183 105780 90224292
Tremor 42.20 9.54 724 297651 152449 90177623
Clostridium difficile colitis 42.06 9.54 187 298188 26519 90303553
Pneumonia 41.84 9.54 2532 295843 635527 89694545
Respiratory tract congestion 41.72 9.54 190 298185 27220 90302852
Blood magnesium decreased 41.63 9.54 130 298245 15563 90314509
Blood pressure systolic abnormal 41.63 9.54 7 298368 19471 90310601
Adverse reaction 41.53 9.54 23 298352 29689 90300383
Phrenic nerve paralysis 41.11 9.54 21 298354 329 90329743
Neutropenic colitis 41.05 9.54 59 298316 4084 90325988
Hot flush 40.70 9.54 335 298040 59153 90270919
Respiratory distress 40.59 9.54 243 298132 38703 90291369
Injection site swelling 40.58 9.54 85 298290 59754 90270318
Pedal pulse abnormal 40.25 9.54 18 298357 206 90329866
Pancreatitis acute 39.85 9.54 210 298165 31905 90298167
Aplasia 39.79 9.54 57 298318 3934 90326138
Blood bilirubin increased 39.57 9.54 262 298113 43208 90286864
Cyclic vomiting syndrome 39.51 9.54 17 298358 176 90329896
Sopor 39.17 9.54 16 298359 24628 90305444
Vasculitis 38.99 9.54 13 298362 22680 90307392
Confusional state 38.57 9.54 972 297403 385233 89944839
Pain in extremity 38.53 9.54 1159 297216 449370 89880702
Hepatocellular injury 38.47 9.54 193 298182 28765 90301307
Basal cell carcinoma 38.45 9.54 32 298343 33357 90296715
Underdose 38.10 9.54 75 298300 53942 90276130
Ejection fraction decreased 37.76 9.54 179 298196 26074 90303998
Immune effector cell-associated neurotoxicity syndrome 37.74 9.54 68 298307 5700 90324372
Bone density decreased 37.59 9.54 6 298369 17339 90312733
Dermatitis diaper 37.29 9.54 19 298356 296 90329776
Neuralgia 37.07 9.54 203 298172 31297 90298775
Otitis media chronic 36.74 9.54 16 298359 171 90329901
Hyponatraemia 36.71 9.54 631 297744 132907 90197165
Cardio-respiratory arrest 36.68 9.54 343 298032 62797 90267275
Lactic acidosis 36.52 9.54 69 298306 50394 90279678
Femur fracture 36.07 9.54 60 298315 46022 90284050
Throat tightness 36.04 9.54 192 298183 29292 90300780
Hospitalisation 35.47 9.54 606 297769 127494 90202578
Influenza 35.42 9.54 650 297725 138614 90191458
Blood pressure systolic increased 35.41 9.54 88 298287 58257 90271815
Tumour pain 35.24 9.54 37 298338 1850 90328222
Troponin increased 35.21 9.54 110 298265 13171 90316901
Hypervolaemia 35.18 9.54 206 298169 32551 90297521
Apnoea 34.83 9.54 88 298287 9326 90320746
Atrial septal defect 34.78 9.54 81 298294 8153 90321919
Radiculopathy 34.72 9.54 9 298366 18496 90311576
Amnesia 34.65 9.54 212 298163 108293 90221779
Influenza like illness 34.63 9.54 412 297963 80199 90249873
Ageusia 34.51 9.54 124 298251 15952 90314120
Angina pectoris 34.43 9.54 234 298141 38926 90291146
Left atrial hypertrophy 34.36 9.54 11 298364 44 90330028
Insomnia 34.18 9.54 836 297539 332638 89997434
Skin candida 34.06 9.54 35 298340 1706 90328366
Weight decreased 34.04 9.54 1553 296822 378357 89951715
Disability 33.83 9.54 51 298324 40694 90289378
Memory impairment 33.67 9.54 452 297923 196792 90133280
Right ventricular hypertrophy 33.43 9.54 25 298350 792 90329280
Anaesthetic complication neurological 33.31 9.54 24 298351 717 90329355
Ileus 33.31 9.54 125 298250 16421 90313651
Toxic erythema of chemotherapy 33.31 9.54 16 298359 218 90329854
Ventilation perfusion mismatch 33.27 9.54 22 298353 570 90329502
Abortion spontaneous 33.22 9.54 81 298294 53975 90276097
Rhinorrhoea 33.08 9.54 440 297935 87876 90242196
Pericardial effusion 32.92 9.54 221 298154 36612 90293460
Postural orthostatic tachycardia syndrome 32.88 9.54 39 298336 2233 90327839
Electrolyte imbalance 32.78 9.54 160 298215 23585 90306487
Neutrophil count abnormal 32.72 9.54 53 298322 4075 90325997
Respiratory failure 32.71 9.54 560 297815 117858 90212214
Schizophrenia 32.68 9.54 5 298370 14909 90315163
Cystitis 32.28 9.54 349 298026 66369 90263703
Device related infection 32.26 9.54 169 298206 25617 90304455
Sedation complication 32.25 9.54 8 298367 16936 90313136
Monoclonal immunoglobulin increased 32.13 9.54 19 298356 402 90329670
Liver function test increased 31.92 9.54 157 298218 84698 90245374
Dry skin 31.84 9.54 436 297939 87637 90242435
Suicide attempt 31.64 9.54 134 298241 75265 90254807
Muscle spasticity 31.61 9.54 212 298163 35110 90294962
Sedation 31.36 9.54 70 298305 48101 90281971
Gastrointestinal injury 31.04 9.54 24 298351 800 90329272
Ischaemic hepatitis 30.99 9.54 42 298333 2751 90327321
Subcutaneous drug absorption impaired 30.95 9.54 4 298371 13541 90316531
COVID-19 30.89 9.54 751 297624 168092 90161980
Sense of oppression 30.86 9.54 27 298348 1073 90328999
Stridor 30.71 9.54 56 298319 4737 90325335
Arthritis 30.56 9.54 378 297997 166937 90163135
Haematemesis 30.53 9.54 203 298172 33523 90296549
Heart rate increased 30.49 9.54 532 297843 112370 90217702
Injection site pruritus 29.79 9.54 85 298290 53749 90276323
Long QT syndrome congenital 29.75 9.54 12 298363 104 90329968
Hypophosphataemia 29.72 9.54 112 298263 14742 90315330
Deep vein thrombosis 29.71 9.54 445 297930 91175 90238897
Dyspepsia 28.99 9.54 468 297907 197692 90132380
Vascular access site thrombosis 28.81 9.54 10 298365 54 90330018
Haemorrhoids 28.73 9.54 168 298207 26534 90303538
Skin necrosis 28.59 9.54 10 298365 16931 90313141
Product complaint 28.52 9.54 5 298370 13495 90316577
Gastrointestinal anastomotic leak 28.33 9.54 15 298360 254 90329818
Laevocardia 28.32 9.54 6 298369 0 90330072
Intestinal perforation 28.05 9.54 105 298270 13776 90316296
Accidental exposure to product 28.04 9.54 61 298314 42305 90287767
Eustachian tube dysfunction 28.02 9.54 22 298353 750 90329322
Osteonecrosis 28.00 9.54 27 298348 26214 90303858
Neurotoxicity 27.76 9.54 142 298233 21325 90308747
Embolism 27.46 9.54 81 298294 9400 90320672
Poisoning deliberate 27.37 9.54 10 298365 16476 90313596
Myocardial reperfusion injury 27.25 9.54 12 298363 132 90329940
Weight fluctuation 27.21 9.54 133 298242 19616 90310456
Streptococcal sepsis 27.04 9.54 45 298330 3539 90326533
Ulcer haemorrhage 27.03 9.54 28 298347 26293 90303779
Blood pressure fluctuation 26.68 9.54 86 298289 52327 90277745
Gastroenteritis radiation 26.65 9.54 19 298356 558 90329514
Lymphocyte count decreased 26.51 9.54 202 298173 34848 90295224
Left ventricular dysfunction 26.42 9.54 107 298268 14562 90315510
Spondylitis 26.40 9.54 7 298368 14171 90315901
Right ventricular enlargement 26.31 9.54 18 298357 494 90329578
Infusion site reaction 26.24 9.54 15 298360 19024 90311048
Nail bed inflammation 26.21 9.54 31 298344 1770 90328302
Cestode infection 26.16 9.54 15 298360 299 90329773
Therapy cessation 26.09 9.54 207 298168 36154 90293918
Food aversion 26.07 9.54 27 298348 1328 90328744
General symptom 25.91 9.54 8 298367 14660 90315412
Creatinine renal clearance decreased 25.89 9.54 15 298360 18884 90311188
Generalised tonic-clonic seizure 25.76 9.54 200 298175 34703 90295369
Feeding disorder 25.62 9.54 120 298255 17392 90312680
Syncope 25.45 9.54 594 297781 132069 90198003
Electrocardiogram PR shortened 25.42 9.54 18 298357 523 90329549
Thrombocytopenic purpura 25.39 9.54 31 298344 1830 90328242
Procedural nausea 25.29 9.54 25 298350 1163 90328909
Vascular access site infection 25.27 9.54 10 298365 82 90329990
Ventricular extrasystoles 24.95 9.54 98 298277 13152 90316920
Escherichia bacteraemia 24.86 9.54 57 298318 5678 90324394
Feeding intolerance 24.73 9.54 23 298352 991 90329081
Decreased immune responsiveness 24.64 9.54 74 298301 8674 90321398
Stress cardiomyopathy 24.52 9.54 98 298277 13257 90316815
Pre-eclampsia 24.38 9.54 86 298289 10962 90319110
Respiratory disorder 24.33 9.54 120 298255 64696 90265376
Coronary artery disease 24.31 9.54 46 298329 33577 90296495
Premature delivery 24.26 9.54 214 298161 38548 90291524
Rhabdomyolysis 24.12 9.54 87 298288 51169 90278903
Septic shock 23.97 9.54 400 297975 83760 90246312
Blood pressure diastolic decreased 23.84 9.54 32 298343 26794 90303278
Otitis media acute 23.81 9.54 24 298351 1143 90328929
Pain 23.56 9.54 2897 295478 993444 89336628
Blood alkaline phosphatase increased 23.49 9.54 252 298123 47827 90282245
Cyanosis 23.31 9.54 126 298249 19329 90310743
Cancer pain 23.27 9.54 45 298330 3980 90326092
Pancreatic neuroendocrine tumour metastatic 23.27 9.54 9 298366 69 90330003
Surgery 23.21 9.54 238 298137 44649 90285423
Congenital anomaly in offspring 23.02 9.54 11 298364 148 90329924
Non-cardiac chest pain 22.99 9.54 61 298314 6660 90323412
Product use issue 22.96 9.54 871 297504 329048 90001024
Pneumothorax 22.87 9.54 124 298251 19043 90311029
Hepatic function abnormal 22.84 9.54 77 298298 46211 90283861
Rash vesicular 22.79 9.54 16 298359 18181 90311891
Frequent bowel movements 22.79 9.54 103 298272 56832 90273240
Flatulence 22.68 9.54 222 298153 41145 90288927
Cervix neoplasm 22.62 9.54 12 298363 204 90329868
Fluid replacement 22.60 9.54 18 298357 627 90329445
Enteritis 22.48 9.54 80 298295 10241 90319831
Myoglobinuria 22.47 9.54 15 298360 395 90329677
Skin fissures 22.43 9.54 131 298244 20678 90309394
Candida infection 22.34 9.54 190 298185 33867 90296205
Metastases to liver 22.34 9.54 167 298208 28640 90301432
Abdominal pain lower 22.31 9.54 173 298202 30004 90300068
Aspartate aminotransferase increased 22.31 9.54 469 297906 102468 90227604
Feeling hot 22.30 9.54 371 298004 77637 90252435
Tenosynovitis 22.28 9.54 10 298365 14557 90315515
Drug dependence 22.20 9.54 39 298336 29288 90300784
Venoocclusive liver disease 22.15 9.54 56 298319 5937 90324135
Drug tolerance 22.11 9.54 16 298359 17900 90312172
Female genital tract fistula 22.00 9.54 16 298359 17852 90312220
Administration site oedema 21.86 9.54 7 298368 28 90330044
Hyperemesis gravidarum 21.64 9.54 19 298356 759 90329313
Dysentery 21.62 9.54 22 298353 1060 90329012
Breast cancer stage I 21.62 9.54 3 298372 9621 90320451
Amputation stump pain 21.48 9.54 7 298368 30 90330042
Cleft palate 21.42 9.54 24 298351 1292 90328780
Procedural vomiting 21.36 9.54 19 298356 772 90329300
Injection site bruising 21.31 9.54 94 298281 52213 90277859
Peripheral sensory neuropathy 21.28 9.54 73 298302 9177 90320895
Capillary leak syndrome 21.22 9.54 35 298340 2732 90327340
Right ventricular dilatation 21.10 9.54 27 298348 1672 90328400
Metastases to peritoneum 21.09 9.54 44 298331 4111 90325961
Iritis 21.05 9.54 41 298334 3645 90326427
Treatment noncompliance 21.05 9.54 93 298282 51634 90278438
Infective pulmonary exacerbation of cystic fibrosis 20.98 9.54 78 298297 10201 90319871
Poor peripheral circulation 20.87 9.54 43 298332 3982 90326090
Metastases to lymph nodes 20.84 9.54 85 298290 11604 90318468
Poor feeding infant 20.72 9.54 16 298359 532 90329540
Nasal mucosal disorder 20.72 9.54 28 298347 1829 90328243
Metastases to meninges 20.67 9.54 41 298334 3694 90326378
Gastroenteropancreatic neuroendocrine tumour disease 20.61 9.54 7 298368 35 90330037
Campylobacter gastroenteritis 20.60 9.54 19 298356 810 90329262
Diabetes mellitus 20.58 9.54 127 298248 64748 90265324
Pallor 20.55 9.54 187 298188 33978 90296094
Panniculitis 20.49 9.54 11 298364 14447 90315625
Infusion site pain 20.47 9.54 123 298252 19615 90310457
Moaning 20.46 9.54 21 298354 1022 90329050
Rectal haemorrhage 20.43 9.54 174 298201 82570 90247502
Dysuria 20.42 9.54 209 298166 39192 90290880
Abdominal distension 20.41 9.54 569 297806 130032 90200040
Seizure like phenomena 20.35 9.54 24 298351 1366 90328706
Drug eruption 20.26 9.54 55 298320 35352 90294720
Hepatitis 20.16 9.54 143 298232 70596 90259476
Neonatal tachypnoea 20.14 9.54 10 298365 147 90329925
Drug level increased 20.05 9.54 38 298337 27724 90302348
Transposition of the great vessels 20.00 9.54 12 298363 261 90329811
Vision blurred 19.99 9.54 490 297885 109803 90220269
Full blood count abnormal 19.86 9.54 196 298179 36401 90293671
Plantar erythema 19.79 9.54 11 298364 206 90329866
Pulmonary thrombosis 19.77 9.54 74 298301 9708 90320364
Congenital pulmonary valve atresia 19.77 9.54 8 298367 70 90330002
Oropharyngeal pain 19.77 9.54 508 297867 114679 90215393
Neutropenic infection 19.77 9.54 27 298348 1782 90328290
Musculoskeletal chest pain 19.75 9.54 140 298235 23610 90306462
Cerebellar stroke 19.67 9.54 14 298361 410 90329662
Pityriasis rosea 19.53 9.54 9 298366 111 90329961
Carbon dioxide decreased 19.52 9.54 34 298341 2774 90327298
Metapneumovirus infection 19.46 9.54 23 298352 1312 90328760
Food intolerance 19.43 9.54 41 298334 3861 90326211
Bulimia nervosa 19.42 9.54 15 298360 499 90329573
Hyperreflexia 19.40 9.54 57 298318 6600 90323472
Genitourinary tract neoplasm 19.28 9.54 7 298368 44 90330028
Platelet transfusion 19.22 9.54 21 298354 1099 90328973
Jaundice neonatal 19.21 9.54 20 298355 990 90329082
Endocrine toxicity 19.02 9.54 7 298368 46 90330026
Nail infection 19.01 9.54 32 298343 2540 90327532
Fracture 18.95 9.54 27 298348 22049 90308023
Anaphylactoid reaction 18.92 9.54 44 298331 4424 90325648
Univentricular heart 18.88 9.54 4 298371 0 90330072
Rash macular 18.86 9.54 167 298208 30113 90299959
Pulmonary oedema 18.77 9.54 298 298077 61782 90268290
Drug clearance decreased 18.76 9.54 27 298348 1871 90328201
Onychalgia 18.70 9.54 21 298354 1133 90328939
Electrocardiogram T wave inversion 18.69 9.54 39 298336 3644 90326428
Colitis ulcerative 18.59 9.54 119 298256 60147 90269925
Nail pigmentation 18.55 9.54 11 298364 234 90329838
Magnesium deficiency 18.52 9.54 17 298358 720 90329352
Pulmonary artery stenosis congenital 18.52 9.54 14 298361 451 90329621
Depression 18.47 9.54 805 297570 299796 90030276
Pulseless electrical activity 18.41 9.54 68 298307 8864 90321208
Myositis 18.35 9.54 32 298343 24096 90305976
Cerebral microhaemorrhage 18.30 9.54 11 298364 240 90329832
Speech disorder 18.28 9.54 230 298145 45355 90284717
Blood pressure increased 18.25 9.54 809 297566 196408 90133664
Cleft lip 18.25 9.54 10 298365 182 90329890
Blood pressure abnormal 18.24 9.54 119 298256 19526 90310546
Malnutrition 18.21 9.54 114 298261 18444 90311628
Gastroenteritis viral 18.18 9.54 166 298209 30189 90299883
Alanine aminotransferase increased 18.06 9.54 514 297861 117824 90212248
Joint effusion 18.04 9.54 23 298352 19687 90310385
Acute myeloid leukaemia 17.94 9.54 123 298252 20517 90309555
Spinal fusion surgery 17.92 9.54 9 298366 12274 90317798
Cataract 17.81 9.54 335 298040 71757 90258315
Atypical pneumonia 17.80 9.54 47 298328 5117 90324955
Gastritis 17.75 9.54 213 298162 41540 90288532
Supraventricular tachycardia 17.71 9.54 103 298272 16233 90313839
Product substitution issue 17.56 9.54 20 298355 17988 90312084
Gastrointestinal disorder 17.56 9.54 679 297696 256008 90074064
Hair texture abnormal 17.54 9.54 44 298331 4643 90325429
Biliary obstruction 17.53 9.54 36 298339 3326 90326746
Lip pruritus 17.50 9.54 22 298353 1338 90328734
Stomatitis haemorrhagic 17.48 9.54 8 298367 97 90329975
Insurance issue 17.46 9.54 77 298298 10881 90319191
Breast cancer metastatic 17.46 9.54 97 298278 15035 90315037
Nasal polyps 17.39 9.54 7 298368 10873 90319199
Subchorionic haemorrhage 17.36 9.54 10 298365 201 90329871
Atrial fibrillation 17.36 9.54 569 297806 133042 90197030
Pulmonary valve stenosis 17.30 9.54 13 298362 415 90329657
5-hydroxyindolacetic acid in urine 17.24 9.54 5 298370 13 90330059
Tongue oedema 17.16 9.54 48 298327 5406 90324666
Renal impairment 17.11 9.54 244 298131 105177 90224895
Proctitis 17.11 9.54 15 298360 15244 90314828
Poisoning 17.01 9.54 15 298360 15202 90314870
Cytopenia 17.00 9.54 107 298268 17342 90312730
Burkholderia cepacia complex infection 16.98 9.54 10 298365 210 90329862
Endoscopic retrograde cholangiopancreatography 16.93 9.54 10 298365 211 90329861
Nephrolithiasis 16.93 9.54 241 298134 48844 90281228
Adenoidal hypertrophy 16.92 9.54 8 298367 105 90329967
Streptococcal bacteraemia 16.85 9.54 28 298347 2199 90327873
Uterine contractions during pregnancy 16.77 9.54 15 298360 614 90329458
Tumour lysis syndrome 16.75 9.54 77 298298 11075 90318997
Cold sweat 16.74 9.54 91 298284 13990 90316082
Hypergeusia 16.72 9.54 5 298370 15 90330057
Abdominal infection 16.70 9.54 29 298346 2361 90327711
Congenital tongue anomaly 16.65 9.54 4 298371 3 90330069
Mucosal dryness 16.62 9.54 34 298341 3133 90326939
Hypoxic-ischaemic encephalopathy 16.61 9.54 43 298332 4625 90325447
Acute pulmonary oedema 16.56 9.54 69 298306 9511 90320561
Alveolitis 16.53 9.54 33 298342 2988 90327084
Hiccups 16.49 9.54 33 298342 2993 90327079
Exposure to allergen 16.45 9.54 14 298361 536 90329536
Ventricular septal defect 16.43 9.54 47 298328 5360 90324712
Visual impairment 16.37 9.54 322 298053 132043 90198029
Otospondylomegaepiphyseal dysplasia 16.33 9.54 8 298367 114 90329958
Multiple-drug resistance 16.17 9.54 3 298372 7773 90322299
Intestinal ischaemia 16.16 9.54 65 298310 8818 90321254
Alopecia areata 16.15 9.54 26 298349 1989 90328083
Venoocclusive disease 16.13 9.54 29 298346 2426 90327646
Metastases to central nervous system 16.13 9.54 106 298269 17436 90312636
Sleep disorder due to a general medical condition 16.12 9.54 84 298291 44654 90285418
Aspartate aminotransferase decreased 15.97 9.54 18 298357 975 90329097
Adverse drug reaction 15.96 9.54 279 298096 116422 90213650
Blood creatinine increased 15.92 9.54 442 297933 100944 90229128
Pulse absent 15.91 9.54 50 298325 6005 90324067
Vein discolouration 15.89 9.54 11 298364 308 90329764
Laboratory test abnormal 15.87 9.54 209 298166 41645 90288427
Hypertonia 15.85 9.54 45 298330 5110 90324962
Hyperaemia 15.84 9.54 30 298345 2612 90327460
Palmar erythema 15.78 9.54 25 298350 1886 90328186
Acute coronary syndrome 15.75 9.54 74 298301 10739 90319333
Gastrointestinal motility disorder 15.74 9.54 50 298325 6041 90324031
Pulmonary valve stenosis congenital 15.71 9.54 9 298366 179 90329893
Pseudomonal sepsis 15.69 9.54 40 298335 4262 90325810
Madarosis 15.66 9.54 36 298339 3593 90326479
Infusion site streaking 15.66 9.54 14 298361 573 90329499
Decerebrate posture 15.62 9.54 8 298367 126 90329946
Hyperglycaemia 15.54 9.54 245 298130 50725 90279347
Transferrin saturation decreased 15.49 9.54 17 298358 894 90329178
Cerebral infarction 15.46 9.54 41 298334 26555 90303517
Hypomania 15.45 9.54 5 298370 8892 90321180
Pharyngeal paraesthesia 15.40 9.54 33 298342 3141 90326931
Glaucoma 15.35 9.54 28 298347 20727 90309345
Paranoia 15.32 9.54 12 298363 12896 90317176
Wrong technique in product usage process 15.31 9.54 156 298219 71415 90258657
Red cell distribution width increased 15.27 9.54 80 298295 12127 90317945
Oral disorder 15.22 9.54 71 298304 10274 90319798
Pelvic mass 15.21 9.54 21 298354 1400 90328672
Blood pressure decreased 15.19 9.54 338 298037 74557 90255515
Uterine perforation 15.15 9.54 57 298318 7497 90322575
Tachypnoea 15.11 9.54 121 298254 21188 90308884
Glioblastoma multiforme 15.08 9.54 17 298358 921 90329151
Colitis microscopic 15.08 9.54 9 298366 11150 90318922
Vocal cord paralysis 15.08 9.54 28 298347 2402 90327670
Electrolyte depletion 15.07 9.54 9 298366 194 90329878
Monocyte count decreased 15.02 9.54 29 298346 2562 90327510
Dysphemia 14.99 9.54 32 298343 3038 90327034
Transmission of an infectious agent via product 14.98 9.54 8 298367 138 90329934
Transplant rejection 14.97 9.54 12 298363 12746 90317326
Cognitive disorder 14.96 9.54 151 298224 69256 90260816
Muscle twitching 14.83 9.54 133 298242 24069 90306003
IIIrd nerve paresis 14.82 9.54 8 298367 141 90329931
Catheter site inflammation 14.81 9.54 17 298358 940 90329132
Lipase increased 14.72 9.54 74 298301 11037 90319035
Laryngeal oedema 14.70 9.54 53 298322 6828 90323244
Plasmacytoma 14.67 9.54 30 298345 2763 90327309
Gastrooesophageal reflux disease 14.66 9.54 426 297949 165911 90164161
Systemic inflammatory response syndrome 14.62 9.54 51 298324 6465 90323607
Laryngeal discomfort 14.61 9.54 12 298363 437 90329635
Disease recurrence 14.54 9.54 69 298306 37584 90292488
Injection site urticaria 14.52 9.54 23 298352 17988 90312084
Overlap syndrome 14.50 9.54 5 298370 8543 90321529
Arteriospasm coronary 14.49 9.54 43 298332 5007 90325065
Abdominal tenderness 14.46 9.54 65 298310 9259 90320813
Tumour marker increased 14.40 9.54 47 298328 5760 90324312
Lipase decreased 14.24 9.54 8 298367 153 90329919
Catheter site infection 14.23 9.54 46 298329 5608 90324464
Disseminated cryptococcosis 14.22 9.54 15 298360 754 90329318
Wheelchair user 14.20 9.54 4 298371 7781 90322291
Pancreatic enzymes abnormal 14.19 9.54 4 298371 9 90330063
Pancreatic carcinoma metastatic 14.18 9.54 27 298348 2361 90327711
Oedema neonatal 14.16 9.54 3 298372 0 90330072
Foetal damage 14.16 9.54 3 298372 0 90330072
Pulmonary oedema neonatal 14.16 9.54 3 298372 0 90330072
Wolff-Parkinson-White syndrome congenital 14.16 9.54 3 298372 0 90330072
Papillary cystadenoma lymphomatosum 14.15 9.54 8 298367 155 90329917
Proctalgia 14.13 9.54 59 298316 8139 90321933
Anomalous pulmonary venous connection 14.13 9.54 6 298369 60 90330012
Pemphigoid 14.12 9.54 6 298369 9020 90321052
Paronychia 14.10 9.54 58 298317 7948 90322124
Biliary dilatation 14.10 9.54 29 298346 2682 90327390
Large intestinal obstruction 14.08 9.54 29 298346 2685 90327387
Coma 14.05 9.54 162 298213 72470 90257602
Haemorrhoidal haemorrhage 14.03 9.54 44 298331 5279 90324793
High density lipoprotein abnormal 14.02 9.54 8 298367 158 90329914
Oral discomfort 14.02 9.54 70 298305 10413 90319659
Inappropriate antidiuretic hormone secretion 13.97 9.54 111 298264 19394 90310678
Dyspnoea exertional 13.96 9.54 324 298051 71964 90258108
Feeling abnormal 13.96 9.54 679 297696 166556 90163516
Bone disorder 13.93 9.54 35 298340 23085 90306987
Grunting 13.93 9.54 9 298366 224 90329848
Skin ulcer 13.90 9.54 102 298273 49973 90280099
Anticholinergic syndrome 13.87 9.54 29 298346 2714 90327358
Hyperthermia 13.81 9.54 69 298306 10266 90319806
Hyperbilirubinaemia neonatal 13.76 9.54 11 298364 385 90329687
Dementia 13.70 9.54 37 298338 23824 90306248
Body temperature abnormal 13.63 9.54 28 298347 2587 90327485
Dermatitis acneiform 13.63 9.54 49 298326 6305 90323767
Epiglottic oedema 13.62 9.54 8 298367 167 90329905
Chronic sinusitis 13.60 9.54 37 298338 23765 90306307
Premenstrual syndrome 13.58 9.54 15 298360 795 90329277
Economic problem 13.56 9.54 32 298343 3249 90326823
Bone marrow failure 13.54 9.54 164 298211 32057 90298015
Drug withdrawal syndrome neonatal 13.50 9.54 26 298349 2293 90327779
Incontinence 13.47 9.54 83 298292 13352 90316720
Coma scale abnormal 13.47 9.54 45 298330 5581 90324491
Neuroleptic malignant syndrome 13.42 9.54 18 298357 15078 90314994
Electrocardiogram ST segment depression 13.41 9.54 32 298343 3271 90326801
Cerumen impaction 13.41 9.54 18 298357 1168 90328904
Psychotic disorder 13.41 9.54 55 298320 31175 90298897
Oesophagitis 13.38 9.54 100 298275 17149 90312923
5-hydroxyindolacetic acid 13.37 9.54 4 298371 12 90330060
Pericardial cyst 13.37 9.54 4 298371 12 90330060
Onychoclasis 13.35 9.54 54 298321 7345 90322727
Cholecystitis 13.33 9.54 99 298276 16941 90313131
Intestinal infarction 13.32 9.54 17 298358 1050 90329022
Hyperbilirubinaemia 13.29 9.54 85 298290 13851 90316221
Metastases to abdominal cavity 13.29 9.54 13 298362 597 90329475
Pancreatitis 13.19 9.54 312 298063 69514 90260558
Injection site phlebitis 13.14 9.54 7 298368 120 90329952
Large intestine perforation 13.09 9.54 65 298310 9647 90320425
Bone marrow myelogram abnormal 13.08 9.54 5 298370 37 90330035
Pneumonia respiratory syncytial viral 13.04 9.54 19 298356 1332 90328740
Toxic encephalopathy 13.01 9.54 60 298315 8639 90321433
Asthma 12.97 9.54 658 297717 241502 90088570
Venous oxygen saturation increased 12.96 9.54 5 298370 38 90330034
Slow response to stimuli 12.96 9.54 17 298358 1079 90328993
Vena cava thrombosis 12.92 9.54 27 298348 2525 90327547
Torticollis 12.88 9.54 27 298348 2531 90327541
Varicose vein 12.84 9.54 53 298322 7274 90322798
Cerebrovascular accident 12.84 9.54 513 297862 123020 90207052
Hypofibrinogenaemia 12.83 9.54 19 298356 1351 90328721
Hypoalbuminaemia 12.81 9.54 93 298282 15804 90314268
Gastric disorder 12.78 9.54 167 298208 33217 90296855
Nasal oedema 12.74 9.54 3 298372 6581 90323491
Diarrhoea haemorrhagic 12.73 9.54 69 298306 10594 90319478
Faeces hard 12.73 9.54 31 298344 3211 90326861
Choking sensation 12.70 9.54 35 298340 3907 90326165
Dacryostenosis congenital 12.70 9.54 4 298371 15 90330057
Meningitis aseptic 12.68 9.54 50 298325 6723 90323349
Blood bilirubin abnormal 12.65 9.54 23 298352 1941 90328131
Device difficult to use 12.65 9.54 24 298351 17501 90312571
Injection site warmth 12.63 9.54 24 298351 17491 90312581
Right atrial dilatation 12.62 9.54 14 298361 745 90329327
Viral infection 12.60 9.54 199 298176 41215 90288857
Muscle contractions involuntary 12.58 9.54 29 298346 2899 90327173
Adult failure to thrive 12.56 9.54 8 298367 194 90329878
Catheter site swelling 12.56 9.54 22 298353 1803 90328269
Bronchiectasis 12.54 9.54 35 298340 22295 90307777
Dyskinesia 12.45 9.54 179 298196 36355 90293717
Pseudomonal bacteraemia 12.40 9.54 23 298352 1971 90328101
Blindness transient 12.39 9.54 38 298337 4505 90325567
Procedural dizziness 12.37 9.54 7 298368 136 90329936
International normalised ratio increased 12.36 9.54 98 298277 47218 90282854
Periorbital cellulitis 12.36 9.54 14 298361 763 90329309
Polymenorrhoea 12.35 9.54 19 298356 1398 90328674
Interstitial lung disease 12.34 9.54 177 298198 76228 90253844
Light chain analysis increased 12.31 9.54 20 298355 1542 90328530
Meningitis streptococcal 12.28 9.54 7 298368 138 90329934
Diverticulitis 12.22 9.54 213 298162 44974 90285098
Sclerodactylia 12.21 9.54 8 298367 204 90329868
Pelvic neoplasm 12.20 9.54 10 298365 363 90329709
Tryptase increased 12.20 9.54 12 298363 555 90329517
Tricuspid valve disease 12.17 9.54 9 298366 280 90329792
Eye injury 12.16 9.54 11 298364 11009 90319063
Presyncope 12.13 9.54 159 298216 31646 90298426
Right-to-left cardiac shunt 12.09 9.54 9 298366 283 90329789
Pregnancy with advanced maternal age 12.09 9.54 3 298372 3 90330069
Multiple drug therapy 12.07 9.54 4 298371 7005 90323067
Vertigo 12.01 9.54 308 298067 69503 90260569
Intentional product misuse 12.00 9.54 383 297992 89221 90240851
Congenital anomaly 12.00 9.54 47 298328 6300 90323772
Enterocolitis infectious 11.97 9.54 23 298352 2024 90328048
Fever neonatal 11.94 9.54 4 298371 19 90330053
Catheter site bruise 11.90 9.54 12 298363 572 90329500
Lethargy 11.89 9.54 282 298093 62857 90267215
Maternal exposure during pregnancy 11.87 9.54 1022 297353 359041 89971031
Protein urine 11.85 9.54 14 298361 798 90329274
Odynophagia 11.82 9.54 60 298315 8983 90321089
Blood sodium decreased 11.80 9.54 141 298234 27472 90302600
Partial seizures with secondary generalisation 11.75 9.54 11 298364 478 90329594
Carbon dioxide abnormal 11.75 9.54 8 298367 218 90329854
Metastatic malignant melanoma 11.73 9.54 20 298355 1604 90328468
Migraine with aura 11.71 9.54 30 298345 3206 90326866
Hemianopia 11.70 9.54 23 298352 2059 90328013
Polyarthritis 11.67 9.54 27 298348 18323 90311749
Hepatic pain 11.66 9.54 32 298343 3563 90326509
Uterine hypotonus 11.64 9.54 7 298368 153 90329919
Chronic hepatitis B 11.63 9.54 10 298365 388 90329684
Congenital anaemia 11.63 9.54 3 298372 4 90330068
Melaena 11.63 9.54 67 298308 34730 90295342
Restless legs syndrome 11.55 9.54 119 298256 22351 90307721
Drug dose omission by device 11.54 9.54 10 298365 10221 90319851
Vaginal cellulitis 11.52 9.54 6 298369 98 90329974
Vascular pain 11.50 9.54 15 298360 947 90329125
Foetal heart rate abnormal 11.50 9.54 15 298360 947 90329125
Velopharyngeal incompetence 11.46 9.54 4 298371 22 90330050
Ureteric obstruction 11.42 9.54 23 298352 2095 90327977
Brain oedema 11.41 9.54 97 298278 17288 90312784
Tremor neonatal 11.40 9.54 7 298368 159 90329913
Exposure to toxic agent 11.38 9.54 6 298369 7961 90322111
Thyroxine free decreased 11.37 9.54 14 298361 834 90329238
Antidepressant discontinuation syndrome 11.36 9.54 7 298368 160 90329912
Vulvovaginal mycotic infection 11.33 9.54 46 298329 6268 90323804
Brain injury 11.30 9.54 53 298322 7685 90322387
Human chorionic gonadotropin decreased 11.26 9.54 6 298369 103 90329969
Metastasis 11.24 9.54 45 298330 6092 90323980
Device adhesion issue 11.21 9.54 4 298371 6687 90323385
Lymphorrhoea 11.20 9.54 5 298370 57 90330015
Portal vein occlusion 11.17 9.54 4 298371 24 90330048
Amniotic cavity infection 11.17 9.54 18 298357 1378 90328694
Hyperacusis 11.16 9.54 27 298348 2784 90327288
Impaired quality of life 11.16 9.54 121 298254 23023 90307049
Rhinovirus infection 11.14 9.54 44 298331 5919 90324153
Blood creatine increased 11.13 9.54 49 298326 6918 90323154
Tracheal injury 11.13 9.54 7 298368 166 90329906
Term birth 11.13 9.54 7 298368 166 90329906
Terminal state 11.12 9.54 27 298348 2791 90327281
Developmental delay 11.07 9.54 20 298355 1680 90328392
Medical device pain 11.06 9.54 19 298356 1533 90328539
Hyperkalaemia 11.03 9.54 149 298226 64815 90265257
Colitis ischaemic 10.99 9.54 74 298301 12272 90317800
Incorrect drug administration rate 10.97 9.54 40 298335 5183 90324889
Hepatobiliary disease 10.93 9.54 11 298364 523 90329549
Abdominal rigidity 10.93 9.54 25 298350 2487 90327585
Ventricular hypoplasia 10.91 9.54 7 298368 172 90329900
Congenital tricuspid valve atresia 10.90 9.54 5 298370 61 90330011
Urine output decreased 10.89 9.54 75 298300 12528 90317544
Otorrhoea 10.88 9.54 21 298354 1854 90328218
Vena cava embolism 10.88 9.54 3 298372 6 90330066
Injection site haemorrhage 10.87 9.54 52 298323 28266 90301806
Immature granulocyte count increased 10.83 9.54 11 298364 529 90329543
Alopecia totalis 10.81 9.54 10 298365 428 90329644
Pharyngotonsillitis 10.81 9.54 7 298368 175 90329897
Right ventricle outflow tract obstruction 10.78 9.54 4 298371 27 90330045
Malaise 10.78 9.54 2136 296239 583850 89746222
Intentional underdose 10.75 9.54 22 298353 2027 90328045
Ovarian hyperstimulation syndrome 10.72 9.54 3 298372 5859 90324213
Protein total decreased 10.68 9.54 49 298326 7040 90323032
COVID-19 pneumonia 10.68 9.54 99 298276 18078 90311994
Haematuria 10.67 9.54 168 298207 34769 90295303
Ketonuria 10.64 9.54 13 298362 768 90329304
Leukocytosis 10.62 9.54 152 298223 30838 90299234
Gastrointestinal sounds abnormal 10.58 9.54 36 298339 4507 90325565
Cephalhaematoma 10.57 9.54 3 298372 7 90330065
Vaginal haemorrhage 10.57 9.54 153 298222 31118 90298954
Respiratory alkalosis 10.51 9.54 30 298345 3418 90326654
Infusion site bruising 10.49 9.54 35 298340 4337 90325735
Restless arm syndrome 10.48 9.54 5 298370 67 90330005
Ear infection 10.46 9.54 164 298211 69611 90260461
Livedo reticularis 10.45 9.54 30 298345 3429 90326643
Blood thyroid stimulating hormone decreased 10.44 9.54 42 298333 5698 90324374
Gastrointestinal stoma complication 10.44 9.54 24 298351 2395 90327677
Hepatic infection 10.39 9.54 12 298363 668 90329404
Acute polyneuropathy 10.37 9.54 10 298365 451 90329621
Electrocardiogram QT shortened 10.30 9.54 7 298368 190 90329882
Preterm premature rupture of membranes 10.30 9.54 19 298356 1622 90328450
Glucocorticoid deficiency 10.25 9.54 11 298364 564 90329508
Tendonitis 10.24 9.54 36 298339 21336 90308736
Gastrostomy tube site complication 10.23 9.54 5 298370 71 90330001
Aggression 10.22 9.54 49 298326 26619 90303453
Clostridium test positive 10.21 9.54 40 298335 5361 90324711
Injection site haematoma 10.21 9.54 5 298370 6917 90323155
Neutrophil percentage abnormal 10.19 9.54 4 298371 32 90330040
Acute sinusitis 10.13 9.54 34 298341 4227 90325845
Heart rate decreased 10.10 9.54 120 298255 53385 90276687
Pre-existing condition improved 10.06 9.54 58 298317 9111 90320961
Cytotoxic oedema 10.05 9.54 7 298368 198 90329874
Excessive eye blinking 10.05 9.54 17 298358 1355 90328717
Right ventricular hypertension 10.03 9.54 3 298372 9 90330063
Biliary catheter insertion 9.99 9.54 4 298371 34 90330038
Drug titration error 9.97 9.54 16 298359 1221 90328851
Multiple congenital abnormalities 9.91 9.54 11 298364 586 90329486
Orthostatic hypotension 9.86 9.54 89 298286 41738 90288334
Anal incontinence 9.84 9.54 89 298286 16141 90313931
Sialoadenitis 9.81 9.54 22 298353 2160 90327912
Eyelid haemangioma 9.79 9.54 3 298372 10 90330062
Small cell lung cancer extensive stage 9.79 9.54 3 298372 10 90330062
Urosepsis 9.78 9.54 110 298265 21122 90308950
Pharyngeal hypoaesthesia 9.75 9.54 9 298366 384 90329688
Gallbladder enlargement 9.74 9.54 14 298361 969 90329103
Anterograde amnesia 9.73 9.54 11 298364 598 90329474
Anorectal disorder 9.72 9.54 21 298354 2010 90328062
Oropharyngeal spasm 9.68 9.54 8 298367 294 90329778
Kidney infection 9.65 9.54 129 298246 25787 90304285
Pulmonary air leakage 9.60 9.54 4 298371 38 90330034
Pulse abnormal 9.59 9.54 27 298348 3052 90327020
Blood urea nitrogen/creatinine ratio increased 9.55 9.54 15 298360 1124 90328948

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1333.42 10.60 2499 163394 183204 42272238
Vomiting 512.93 10.60 2357 163536 287366 42168076
Drug ineffective 453.99 10.60 1128 164765 629069 41826373
Nausea 407.92 10.60 2788 163105 394011 42061431
Drug abuse 275.33 10.60 40 165853 104731 42350711
Toxicity to various agents 269.35 10.60 297 165596 228839 42226603
Cytokine release syndrome 268.21 10.60 558 165335 43969 42411473
Constipation 248.47 10.60 1268 164625 161023 42294419
Completed suicide 227.01 10.60 49 165844 96416 42359026
Aplastic anaemia 214.80 10.60 253 165640 12131 42443311
Fatigue 172.55 10.60 2511 163382 433130 42022312
Diarrhoea 160.12 10.60 2598 163295 458251 41997191
Neutropenia 152.66 10.60 1310 164583 198121 42257321
Appendicolith 152.54 10.60 223 165670 13233 42442209
Left-to-right cardiac shunt 146.92 10.60 35 165858 15 42455427
Pyrexia 146.40 10.60 2247 163646 391795 42063647
Therapeutic product effect incomplete 144.29 10.60 48 165845 70891 42384551
Serotonin syndrome 139.62 10.60 310 165583 25535 42429907
Plasma cell myeloma 136.73 10.60 452 165441 47126 42408316
Abdominal pain 135.83 10.60 1232 164661 189239 42266203
Mucosal inflammation 133.01 10.60 459 165434 48915 42406527
Appendicitis 127.21 10.60 261 165632 20352 42435090
Ventricular fibrillation 125.78 10.60 327 165566 29796 42425646
Overdose 118.53 10.60 141 165752 105123 42350319
Intentional overdose 117.28 10.60 28 165865 51428 42404014
Sepsis 111.88 10.60 1227 164666 198107 42257335
Febrile bone marrow aplasia 111.47 10.60 166 165727 10015 42445427
Treatment failure 105.49 10.60 56 165837 62568 42392874
Thrombocytopenia 101.63 10.60 1160 164733 189119 42266323
Hospice care 100.74 10.60 144 165749 8369 42447073
Myocardial infarction 99.81 10.60 208 165685 123801 42331641
Rhabdomyolysis 99.57 10.60 94 165799 77925 42377517
Suicide attempt 99.49 10.60 28 165865 46072 42409370
Electrocardiogram QT prolonged 99.48 10.60 410 165483 47535 42407907
Dehydration 96.93 10.60 909 164984 140858 42314584
Rheumatoid arthritis 94.95 10.60 24 165869 42416 42413026
Chills 94.12 10.60 658 165235 93408 42362034
Heart disease congenital 92.55 10.60 62 165831 1380 42454062
Drug resistance 92.45 10.60 12 165881 34236 42421206
Condition aggravated 84.00 10.60 632 165261 260122 42195320
Death 83.26 10.60 2410 163483 468775 41986667
Neuropathy peripheral 83.05 10.60 679 165214 101174 42354268
Otitis media chronic 83.01 10.60 27 165866 93 42455349
Lymphoid tissue hypoplasia 82.26 10.60 48 165845 830 42454612
Failure to thrive 81.58 10.60 138 165755 9284 42446158
Blood phosphorus increased 81.33 10.60 162 165731 12363 42443079
Thymus hypoplasia 80.43 10.60 47 165846 815 42454627
Blood creatine phosphokinase increased 78.83 10.60 45 165848 48293 42407149
Flushing 77.88 10.60 318 165575 36710 42418732
Bacterial infection 75.78 10.60 260 165633 27619 42427823
Congenital anomaly 75.11 10.60 56 165837 1485 42453957
Loss of personal independence in daily activities 73.52 10.60 52 165841 49764 42405678
Torsade de pointes 70.64 10.60 123 165770 8471 42446971
Arthralgia 68.66 10.60 492 165401 204746 42250696
Interstitial lung disease 67.94 10.60 126 165767 78336 42377106
White blood cell count decreased 66.22 10.60 689 165204 109707 42345735
Hyperphosphataemia 65.79 10.60 152 165741 12852 42442590
Hypophosphataemia 65.60 10.60 205 165688 20740 42434702
Hyponatraemia 65.06 10.60 642 165251 100820 42354622
Decreased appetite 64.84 10.60 1084 164809 192053 42263389
Hepatic function abnormal 64.77 10.60 63 165830 51504 42403938
Nephrolithiasis 64.23 10.60 299 165594 36531 42418911
Injection site pain 62.32 10.60 80 165813 57718 42397724
Suicidal ideation 61.47 10.60 58 165835 48103 42407339
Aggression 60.20 10.60 50 165843 44113 42411329
Analgesic therapy 58.41 10.60 97 165796 6427 42449015
Abdominal distension 58.32 10.60 478 165415 71257 42384185
Drug ineffective for unapproved indication 57.28 10.60 57 165836 46106 42409336
Hyperhidrosis 57.19 10.60 571 165322 89941 42365501
Drug interaction 56.42 10.60 717 165176 266282 42189160
Myasthenia gravis 56.24 10.60 164 165729 15973 42439469
Wrong technique in product usage process 56.01 10.60 50 165843 42585 42412857
Sleep disorder therapy 55.79 10.60 98 165795 6796 42448646
Ascites 55.79 10.60 395 165498 56283 42399159
Therapeutic product effect decreased 55.02 10.60 43 165850 39107 42416335
Weight increased 54.82 10.60 225 165668 107758 42347684
Inappropriate schedule of product administration 54.40 10.60 191 165702 95711 42359731
Therapeutic response decreased 54.13 10.60 39 165854 36973 42418469
Cardiogenic shock 54.03 10.60 278 165615 35362 42420080
Neutropenic colitis 53.46 10.60 76 165817 4394 42451048
Renal impairment 53.30 10.60 234 165659 109994 42345448
Encephalopathy 52.33 10.60 307 165586 41026 42414416
Prostate cancer 52.16 10.60 58 165835 44585 42410857
Stomatitis 51.44 10.60 354 165539 49975 42405467
Myalgia 49.52 10.60 199 165694 95881 42359561
Coma 49.06 10.60 83 165810 53471 42401971
Anaphylactic reaction 48.75 10.60 309 165584 42434 42413008
Ventricular tachyarrhythmia 47.86 10.60 26 165867 389 42455053
Disseminated aspergillosis 47.22 10.60 45 165848 1685 42453757
Depression 46.53 10.60 249 165644 111114 42344328
Neutrophil count decreased 45.99 10.60 412 165481 63003 42392439
Tachycardia 45.92 10.60 598 165295 100489 42354953
Clostridium difficile colitis 45.06 10.60 183 165710 21069 42434373
Drug dependence 44.76 10.60 29 165864 29065 42426377
Drug therapy 44.44 10.60 85 165808 6295 42449147
Psoriasis 43.91 10.60 76 165817 48528 42406914
Hypoxia 42.98 10.60 438 165455 69348 42386094
Negative pressure pulmonary oedema 42.85 10.60 28 165865 597 42454845
Platelet transfusion 42.36 10.60 42 165851 1652 42453790
Aplasia 42.02 10.60 71 165822 4772 42450670
Nightmare 41.38 10.60 200 165693 24812 42430630
Hypersensitivity 40.72 10.60 446 165447 71924 42383518
Therapy non-responder 40.01 10.60 93 165800 53266 42402176
Cardiac failure congestive 40 10.60 184 165709 85418 42370024
Immune effector cell-associated neurotoxicity syndrome 39.78 10.60 103 165790 9358 42446084
Erythema 39.58 10.60 619 165274 108174 42347268
Monocyte chemotactic protein-1 increased 39.53 10.60 22 165871 346 42455096
Developmental delay 39.39 10.60 55 165838 3127 42452315
Alpha tumour necrosis factor increased 39.25 10.60 22 165871 351 42455091
Neuralgia 38.84 10.60 200 165693 25447 42429995
Psychotic disorder 38.66 10.60 34 165859 29174 42426268
Cerebral infarction 38.08 10.60 39 165854 31130 42424312
Anal inflammation 37.76 10.60 45 165848 2184 42453258
Sedation 37.70 10.60 225 165668 30250 42425192
Angina pectoris 37.06 10.60 44 165849 32852 42422590
Oral pain 36.46 10.60 120 165773 12476 42442966
Laevocardia 36.42 10.60 8 165885 0 42455442
Arthritis 36.00 10.60 68 165825 41997 42413445
Proctalgia 35.98 10.60 83 165810 7010 42448432
Eustachian tube dysfunction 35.82 10.60 13 165880 67 42455375
Transfusion 35.82 10.60 106 165787 10408 42445034
Platelet count decreased 35.76 10.60 747 165146 137834 42317608
Arteriosclerosis coronary artery 35.65 10.60 14 165879 18663 42436779
Back pain 35.54 10.60 761 165132 141015 42314427
Obstructive airways disorder 35.03 10.60 27 165866 24732 42430710
Acute myocardial infarction 34.91 10.60 113 165780 58052 42397390
Asthenia 34.79 10.60 1379 164514 279414 42176028
Blood uric acid increased 34.66 10.60 136 165757 15411 42440031
Synovitis 34.44 10.60 9 165884 15558 42439884
Right ventricular hypertrophy 34.30 10.60 36 165857 1516 42453926
Erectile dysfunction 34.20 10.60 28 165865 24885 42430557
Type I hypersensitivity 33.88 10.60 42 165851 2124 42453318
Lactic acidosis 33.84 10.60 79 165814 45182 42410260
Full blood count decreased 33.72 10.60 164 165729 20396 42435046
SARS-CoV-2 test negative 33.69 10.60 38 165855 1737 42453705
Asthma 33.42 10.60 127 165766 62187 42393255
Tumour lysis syndrome 33.41 10.60 173 165720 22058 42433384
Infusion related reaction 33.41 10.60 373 165520 60433 42395009
Rash maculo-papular 33.26 10.60 255 165638 37248 42418194
Coronary artery disease 33.20 10.60 103 165790 53617 42401825
Psoriatic arthropathy 33.12 10.60 29 165864 24938 42430504
Small intestinal obstruction 33.11 10.60 143 165750 16918 42438524
Otitis media acute 33.08 10.60 25 165868 677 42454765
Incorrect route of product administration 33.03 10.60 184 165709 24121 42431321
Congenital nystagmus 33.00 10.60 13 165880 87 42455355
Malignant neoplasm progression 32.58 10.60 598 165295 107802 42347640
Joint swelling 32.50 10.60 145 165748 67877 42387565
Fall 32.17 10.60 682 165211 233838 42221604
Pancytopenia 32.13 10.60 640 165253 117103 42338339
Disease recurrence 32.06 10.60 41 165852 29637 42425805
Atelectasis neonatal 31.87 10.60 7 165886 0 42455442
Fear 31.72 10.60 3 165890 10962 42444480
Hypokalaemia 31.60 10.60 422 165471 71299 42384143
Intentional self-injury 31.40 10.60 10 165883 15192 42440250
Paranoia 31.24 10.60 8 165885 14018 42441424
Anaemia 30.97 10.60 1360 164533 278918 42176524
Labelled drug-drug interaction medication error 30.88 10.60 11 165882 15571 42439871
Myelosuppression 30.75 10.60 70 165823 40391 42415051
Product used for unknown indication 30.45 10.60 30 165863 1171 42454271
Stress 30.40 10.60 284 165609 43928 42411514
Gastrointestinal haemorrhage 30.37 10.60 239 165654 97487 42357955
Diabetes mellitus inadequate control 30.27 10.60 11 165882 15379 42440063
Laryngospasm 30.22 10.60 38 165855 1950 42453492
Hypoglycaemia 30.18 10.60 125 165768 59729 42395713
Disease progression 29.50 10.60 750 165143 142906 42312536
Colitis 29.48 10.60 294 165599 46278 42409164
Antacid therapy 29.42 10.60 60 165833 4657 42450785
Hyperkalaemia 29.28 10.60 188 165705 80270 42375172
Blood pressure fluctuation 29.25 10.60 37 165856 26871 42428571
Extravasation 29.12 10.60 41 165852 2349 42453093
Impaired gastric emptying 28.98 10.60 57 165836 4309 42451133
Heart rate decreased 28.75 10.60 62 165831 36470 42418972
Congenital hydrocephalus 28.70 10.60 14 165879 165 42455277
Mechanical ventilation complication 28.67 10.60 23 165870 681 42454761
Disturbance in attention 28.55 10.60 45 165848 29821 42425621
Electrocardiogram T wave biphasic 28.49 10.60 15 165878 210 42455232
Gynaecomastia 28.31 10.60 7 165886 12560 42442882
Change of bowel habit 28.25 10.60 28 165865 1101 42454341
Poisoning 28.08 10.60 11 165882 14688 42440754
Adenoidal hypertrophy 27.91 10.60 14 165879 176 42455266
Embolism 27.65 10.60 86 165807 8677 42446765
Pulmonary artery stenosis congenital 27.50 10.60 20 165873 510 42454932
Administration site inflammation 27.48 10.60 10 165883 52 42455390
Anticoagulant therapy 27.47 10.60 57 165836 4478 42450964
Interleukin level increased 27.40 10.60 25 165868 885 42454557
Iron deficiency 27.34 10.60 100 165793 10961 42444481
Dry mouth 27.34 10.60 256 165637 39623 42415819
Enterocolitis infectious 27.16 10.60 36 165857 1947 42453495
Altered state of consciousness 27.12 10.60 45 165848 29214 42426228
Fixed eruption 26.84 10.60 40 165853 2414 42453028
Accidental overdose 26.79 10.60 43 165850 28287 42427155
Upper respiratory tract infection 26.59 10.60 266 165627 41907 42413535
Musculoskeletal stiffness 26.48 10.60 125 165768 57640 42397802
Incorrect dose administered 26.48 10.60 111 165782 52863 42402579
Cardiac failure 26.38 10.60 277 165616 106579 42348863
Cleft palate 26.29 10.60 21 165872 618 42454824
Bladder cancer 26.21 10.60 17 165876 17030 42438412
Tubulointerstitial nephritis 26.13 10.60 52 165841 31496 42423946
Bacteraemia 26.10 10.60 177 165716 24863 42430579
Immune-mediated hepatitis 25.94 10.60 50 165843 3724 42451718
Blood glucose increased 25.91 10.60 174 165719 73525 42381917
Oxygen saturation immeasurable 25.88 10.60 9 165884 40 42455402
Thrombosis 25.74 10.60 392 165501 68119 42387323
Treatment noncompliance 25.64 10.60 69 165824 37603 42417839
C-reactive protein abnormal 25.59 10.60 3 165890 9258 42446184
Schizophrenia 25.54 10.60 5 165888 10545 42444897
Pneumonia 25.27 10.60 1938 163955 420211 42035231
Cerebrovascular accident 25.17 10.60 249 165644 96911 42358531
Poor feeding infant 25.09 10.60 23 165870 819 42454623
Hypoplastic left heart syndrome 25.06 10.60 14 165879 222 42455220
Taste disorder 24.99 10.60 92 165801 10115 42445327
Nasopharyngitis 24.92 10.60 208 165685 83788 42371654
Anaphylactoid shock 24.75 10.60 18 165875 459 42454983
Parainfluenzae virus infection 24.71 10.60 48 165845 3595 42451847
Depressed mood 24.55 10.60 33 165860 23351 42432091
Feeling hot 24.48 10.60 166 165727 23316 42432126
Blood pressure measurement 24.38 10.60 13 165880 187 42455255
Atrial septal defect 24.33 10.60 77 165816 7842 42447600
Substance abuse 24.32 10.60 3 165890 8902 42446540
Poisoning deliberate 24.12 10.60 5 165888 10129 42445313
Myopathy 23.62 10.60 12 165881 13749 42441693
Melaena 23.44 10.60 75 165818 38671 42416771
Right aortic arch 23.31 10.60 7 165886 17 42455425
Hypophagia 23.19 10.60 182 165711 26774 42428668
Pemphigoid 22.88 10.60 8 165885 11459 42443983
Stridor 22.83 10.60 40 165853 2768 42452674
Osteonecrosis 22.83 10.60 17 165876 15848 42439594
Angina unstable 22.82 10.60 8 165885 11440 42444002
Neurotoxicity 22.78 10.60 164 165729 23487 42431955
Osteoporosis 22.73 10.60 15 165878 14891 42440551
Coarctation of the aorta 22.57 10.60 17 165876 458 42454984
Atrioventricular block complete 22.56 10.60 8 165885 11356 42444086
Swollen tongue 22.25 10.60 30 165863 21201 42434241
Dermatitis diaper 22.23 10.60 15 165878 338 42455104
Clonus 22.22 10.60 45 165848 3475 42451967
Hyperbilirubinaemia 22.19 10.60 147 165746 20488 42434954
Multiple congenital abnormalities 22.18 10.60 18 165875 542 42454900
Eczema 22.03 10.60 64 165829 34022 42421420
Chemotherapeutic drug level increased 21.90 10.60 14 165879 287 42455155
Pain in extremity 21.80 10.60 434 165459 150170 42305272
Drug reaction with eosinophilia and systemic symptoms 21.75 10.60 87 165806 41988 42413454
Dyslipidaemia 21.70 10.60 5 165888 9413 42446029
Post procedural hypotension 21.70 10.60 9 165884 70 42455372
Transplant rejection 21.65 10.60 13 165880 13575 42441867
Dysentery 21.47 10.60 16 165877 424 42455018
Coronary artery occlusion 21.39 10.60 8 165885 10989 42444453
Blood calcium increased 21.38 10.60 77 165816 8377 42447065
Tendonitis 21.36 10.60 6 165887 9888 42445554
Depressed level of consciousness 21.29 10.60 105 165788 47865 42407577
Sleep disorder due to a general medical condition 21.13 10.60 22 165871 17431 42438011
Endocardial fibroelastosis 21.11 10.60 6 165887 11 42455431
Malignant catatonia 20.86 10.60 16 165877 443 42454999
Cleft lip 20.81 10.60 14 165879 314 42455128
Walking aid user 20.75 10.60 37 165856 2596 42452846
Clostridium difficile infection 20.61 10.60 155 165738 22504 42432938
Painful respiration 20.54 10.60 26 165867 1343 42454099
Wheezing 20.44 10.60 127 165766 54654 42400788
Vasculitis 20.30 10.60 25 165868 18369 42437073
Blood creatine decreased 20.27 10.60 13 165880 268 42455174
Joint range of motion decreased 20.25 10.60 3 165890 7750 42447692
Stoma site pain 20.25 10.60 20 165873 783 42454659
International normalised ratio increased 19.93 10.60 108 165785 48060 42407382
Aortic stenosis 19.90 10.60 77 165816 8668 42446774
Pulse absent 19.88 10.60 62 165831 6265 42449177
Penile oedema 19.82 10.60 16 165877 478 42454964
Forced expiratory volume decreased 19.82 10.60 3 165890 7627 42447815
Anaphylactic shock 19.80 10.60 158 165735 23359 42432083
Sepsis neonatal 19.74 10.60 13 165880 281 42455161
Glycosylated haemoglobin increased 19.72 10.60 13 165880 12911 42442531
Obesity 19.65 10.60 21 165872 16438 42439004
Gait disturbance 19.60 10.60 266 165627 97734 42357708
Hypoplastic right heart syndrome 19.58 10.60 6 165887 16 42455426
Type 2 diabetes mellitus 19.46 10.60 26 165867 18445 42436997
Erythropenia 19.34 10.60 12 165881 233 42455209
Uveitis 19.28 10.60 6 165887 9252 42446190
Arteriosclerosis 19.28 10.60 25 165868 17964 42437478
Drug eruption 19.14 10.60 38 165855 23037 42432405
Enteritis 18.99 10.60 88 165805 10728 42444714
Hypotension 18.90 10.60 1203 164690 256428 42199014
Testicular germ cell cancer metastatic 18.88 10.60 8 165885 66 42455376
Hallucination, auditory 18.84 10.60 18 165875 14846 42440596
Epistaxis 18.81 10.60 365 165528 66461 42388981
Injection site swelling 18.80 10.60 23 165870 16950 42438492
Pulmonary alveolar haemorrhage 18.72 10.60 18 165875 14798 42440644
Immune reconstitution inflammatory syndrome 18.71 10.60 8 165885 10135 42445307
Croup infectious 18.71 10.60 16 165877 519 42454923
Neutropenic sepsis 18.62 10.60 116 165777 15830 42439612
Right ventricular enlargement 18.61 10.60 16 165877 523 42454919
Cytomegalovirus infection 18.53 10.60 64 165829 32242 42423200
Colitis ulcerative 18.53 10.60 47 165846 26128 42429314
Blood test abnormal 18.41 10.60 99 165794 12807 42442635
Meconium abnormal 18.38 10.60 8 165885 71 42455371
Basal cell carcinoma 18.37 10.60 38 165855 22695 42432747
Bronchiectasis 18.34 10.60 26 165867 17993 42437449
Abnormal behaviour 18.34 10.60 48 165845 26403 42429039
Vessel puncture site inflammation 18.21 10.60 4 165889 0 42455442
Embryonal rhabdomyosarcoma 18.21 10.60 4 165889 0 42455442
Prepuce redundant 18.21 10.60 4 165889 0 42455442
Visual acuity reduced 18.19 10.60 25 165868 17525 42437917
Medication error 18.14 10.60 67 165826 33087 42422355
Pleural effusion 18.12 10.60 501 165392 96665 42358777
Asphyxia 18.06 10.60 5 165888 8321 42447121
Frequent bowel movements 17.97 10.60 35 165858 21372 42434070
Coronary artery stenosis 17.89 10.60 9 165884 10370 42445072
Ankylosing spondylitis 17.82 10.60 3 165890 7053 42448389
Perihepatic abscess 17.81 10.60 9 165884 115 42455327
General physical health deterioration 17.81 10.60 739 165154 150507 42304935
Malnutrition 17.75 10.60 107 165786 14435 42441007
Hepatic cytolysis 17.74 10.60 171 165722 26673 42428769
Blood pressure systolic increased 17.72 10.60 53 165840 27915 42427527
Inflammatory pain 17.71 10.60 16 165877 559 42454883
Injection site haemorrhage 17.64 10.60 12 165881 11724 42443718
Dementia 17.56 10.60 23 165870 16457 42438985
Nephrotic syndrome 17.54 10.60 6 165887 8712 42446730
Streptococcal bacteraemia 17.42 10.60 35 165858 2687 42452755
Posterior reversible encephalopathy syndrome 17.38 10.60 97 165796 12724 42442718
Skin ulcer 17.34 10.60 47 165846 25554 42429888
Cataract 17.31 10.60 61 165832 30543 42424899
Liver function test increased 17.19 10.60 135 165758 19863 42435579
Post transplant lymphoproliferative disorder 17.14 10.60 7 165886 9113 42446329
Right-to-left cardiac shunt 17.13 10.60 10 165883 173 42455269
Blood triglycerides increased 17.13 10.60 22 165871 15874 42439568
Road traffic accident 17.11 10.60 30 165863 19063 42436379
Syringe issue 17.02 10.60 6 165887 8550 42446892
Epilepsy 17.01 10.60 49 165844 26122 42429320
Normochromic normocytic anaemia 16.86 10.60 7 165886 9024 42446418
Right ventricular dilatation 16.83 10.60 18 165875 775 42454667
Gingival pain 16.82 10.60 6 165887 8488 42446954
Blood magnesium decreased 16.75 10.60 67 165826 7659 42447783
Device malfunction 16.74 10.60 14 165879 12313 42443129
Congenital aortic stenosis 16.73 10.60 8 165885 90 42455352
Infusion site urticaria 16.64 10.60 10 165883 183 42455259
Accidental exposure to product 16.56 10.60 34 165859 20359 42435083
Photosensitivity reaction 16.55 10.60 15 165878 12687 42442755
Bradycardia 16.39 10.60 234 165659 85250 42370192
Product substitution issue 16.37 10.60 12 165881 11278 42444164
Drug use disorder 16.30 10.60 10 165883 10323 42445119
Urethral valves 16.22 10.60 11 165882 250 42455192
Systemic lupus erythematosus 16.20 10.60 8 165885 9316 42446126
Movement disorder 16.19 10.60 20 165873 14678 42440764
Palmar-plantar erythrodysaesthesia syndrome 16.10 10.60 136 165757 20446 42434996
Impaired work ability 16.09 10.60 14 165879 12077 42443365
Knee arthroplasty 16.08 10.60 7 165886 8774 42446668
Arthropathy 16.07 10.60 60 165833 29537 42425905
Procalcitonin decreased 16.07 10.60 11 165882 254 42455188
Univentricular heart 16.07 10.60 6 165887 34 42455408
End stage renal disease 16.05 10.60 115 165778 16443 42438999
Underdose 16.04 10.60 25 165868 16641 42438801
Pulmonary oedema neonatal 15.98 10.60 4 165889 3 42455439
Hallucination 15.90 10.60 145 165748 57362 42398080
Ageusia 15.86 10.60 88 165805 11517 42443925
Pulmonary embolism 15.85 10.60 592 165301 119020 42336422
Respiratory arrest 15.84 10.60 57 165836 28367 42427075
Drug-induced liver injury 15.73 10.60 86 165807 38187 42417255
Eosinophil percentage decreased 15.63 10.60 11 165882 266 42455176
Pseudomonal bacteraemia 15.56 10.60 31 165862 2365 42453077
Pathogen resistance 15.55 10.60 13 165880 11437 42444005
Oxygen saturation decreased 15.48 10.60 345 165548 64342 42391100
Hyperaemia 15.46 10.60 24 165869 1502 42453940
Palpitations 15.42 10.60 125 165768 50672 42404770
Electrocardiogram QT shortened 15.40 10.60 9 165884 156 42455286
Bronchopulmonary aspergillosis allergic 15.32 10.60 46 165847 4552 42450890
Oropharyngeal discomfort 15.26 10.60 43 165850 4106 42451336
Right atrial enlargement 15.24 10.60 11 165882 277 42455165
Activated partial thromboplastin time prolonged 15.15 10.60 110 165783 15793 42439649
Ventricular hypoplasia 15.10 10.60 7 165886 73 42455369
Enterococcus test positive 15.01 10.60 25 165868 1660 42453782
Appetite disorder 14.98 10.60 35 165858 2980 42452462
Osteoarthritis 14.93 10.60 47 165846 24358 42431084
Suspected suicide 14.88 10.60 3 165890 6196 42449246
Sexual dysfunction 14.83 10.60 4 165889 6771 42448671
Oesophageal irritation 14.77 10.60 7 165886 77 42455365
Product use issue 14.74 10.60 210 165683 76541 42378901
Rectal haemorrhage 14.63 10.60 123 165770 49483 42405959
Lung opacity 14.62 10.60 53 165840 5784 42449658
Velopharyngeal incompetence 14.60 10.60 5 165888 21 42455421
Necrotising retinitis 14.57 10.60 19 165874 1011 42454431
Angioedema 14.57 10.60 101 165792 42376 42413066
Body temperature decreased 14.47 10.60 21 165872 14392 42441050
Subileus 14.46 10.60 38 165855 3483 42451959
Laryngeal discomfort 14.42 10.60 10 165883 236 42455206
Hypomagnesaemia 14.41 10.60 172 165721 28316 42427126
Tuberculosis 14.30 10.60 11 165882 10088 42445354
Chronic graft versus host disease 14.28 10.60 3 165890 6022 42449420
Lymphoma 14.25 10.60 21 165872 14300 42441142
Cardiac failure chronic 14.19 10.60 10 165883 9591 42445851
Anaphylactoid reaction 14.14 10.60 34 165859 2949 42452493
Therapy partial responder 14.13 10.60 36 165857 19985 42435457
Total lung capacity decreased 14.13 10.60 38 165855 3532 42451910
Feeding disorder 14.12 10.60 68 165825 8423 42447019
Electrocardiogram ST segment elevation 14.10 10.60 53 165840 5886 42449556
Miosis 14.09 10.60 19 165874 13427 42442015
Parenteral nutrition 14.04 10.60 15 165878 645 42454797
Agonal respiration 14.03 10.60 7 165886 87 42455355
Injection site mass 13.95 10.60 8 165885 8567 42446875
Unresponsive to stimuli 13.92 10.60 185 165708 31218 42424224
Pulmonary fibrosis 13.90 10.60 55 165838 26626 42428816
Exposure during pregnancy 13.87 10.60 8 165885 8540 42446902
Placental transfusion syndrome 13.85 10.60 4 165889 8 42455434
Tachypnoea 13.83 10.60 137 165756 21525 42433917
Lumbar vertebral fracture 13.77 10.60 35 165858 3144 42452298
Klebsiella test positive 13.76 10.60 19 165874 1069 42454373
Cellulitis 13.66 10.60 325 165568 61260 42394182
Adenoiditis 13.66 10.60 3 165890 0 42455442
Cardiac malposition 13.66 10.60 3 165890 0 42455442
Neonatal cardiac failure 13.66 10.60 3 165890 0 42455442
Cardiomyopathy neonatal 13.66 10.60 3 165890 0 42455442
Cytomegalovirus infection reactivation 13.64 10.60 14 165879 11164 42444278
Injection site pruritus 13.63 10.60 10 165883 9395 42446047
Body temperature increased 13.61 10.60 130 165763 20228 42435214
Neutrophil count abnormal 13.59 10.60 32 165861 2739 42452703
Arteriospasm coronary 13.59 10.60 45 165848 4693 42450749
Product dose omission issue 13.56 10.60 478 165415 153887 42301555
Tardive dyskinesia 13.53 10.60 5 165888 6919 42448523
Troponin T increased 13.52 10.60 32 165861 2748 42452694
Cardiac arrest 13.52 10.60 537 165356 108783 42346659
Glomerular filtration rate decreased 13.50 10.60 27 165866 16324 42439118
Acute graft versus host disease in skin 13.47 10.60 6 165887 7418 42448024
Troponin increased 13.38 10.60 123 165770 18939 42436503
Therapeutic response shortened 13.36 10.60 20 165873 13534 42441908
Haemorrhage 13.36 10.60 161 165732 60402 42395040
Large intestine anastomosis 13.34 10.60 6 165887 58 42455384
Hypopnoea 13.34 10.60 7 165886 7875 42447567
Device issue 13.25 10.60 20 165873 13489 42441953
Pathological fracture 13.20 10.60 48 165845 5245 42450197
Oesophageal carcinoma 13.18 10.60 11 165882 9685 42445757
Impetigo 13.16 10.60 21 165872 1345 42454097
Neutropenic infection 13.10 10.60 25 165868 1848 42453594
Psychomotor hyperactivity 13.06 10.60 14 165879 10944 42444498
Gastrointestinal malformation 13.05 10.60 7 165886 102 42455340
Intentional product use issue 12.95 10.60 199 165694 71634 42383808
Myoclonus 12.95 10.60 112 165781 16953 42438489
Product administration error 12.93 10.60 33 165860 18310 42437132
Osteonecrosis of jaw 12.88 10.60 35 165858 19014 42436428
Viral rash 12.87 10.60 8 165885 156 42455286
Patent ductus arteriosus 12.76 10.60 36 165857 3440 42452002
Drug level decreased 12.74 10.60 12 165881 9965 42445477
Urine sodium decreased 12.73 10.60 8 165885 159 42455283
Subarachnoid haemorrhage 12.73 10.60 23 165870 14449 42440993
Phlebitis 12.71 10.60 41 165852 4217 42451225
Blood pressure diastolic abnormal 12.71 10.60 4 165889 6124 42449318
Aorta hypoplasia 12.70 10.60 7 165886 108 42455334
Incarcerated umbilical hernia 12.63 10.60 5 165888 34 42455408
Blood pressure systolic abnormal 12.61 10.60 3 165890 5525 42449917
Red blood cell sedimentation rate increased 12.60 10.60 12 165881 9912 42445530
Procedural nausea 12.58 10.60 7 165886 110 42455332
Fracture 12.57 10.60 8 165885 8095 42447347
Mental status changes 12.52 10.60 232 165661 41883 42413559
Mean cell haemoglobin concentration decreased 12.50 10.60 22 165871 1528 42453914
Device leakage 12.41 10.60 13 165880 10272 42445170
COVID-19 12.36 10.60 350 165543 115598 42339844
Anxiety 12.36 10.60 359 165534 118201 42337241
Cognitive disorder 12.35 10.60 80 165813 34092 42421350
Hyperthermia malignant 12.29 10.60 30 165863 2628 42452814
Injection site erythema 12.28 10.60 39 165854 20156 42435286
Sleep apnoea syndrome 12.26 10.60 43 165850 21565 42433877
Respiratory rate increased 12.24 10.60 15 165878 11047 42444395
Apathy 12.10 10.60 9 165884 8397 42447045
Epstein-Barr virus infection 12.05 10.60 12 165881 9706 42445736
Euphoric mood 12.05 10.60 5 165888 6448 42448994
Medical device site fistula 12.04 10.60 5 165888 39 42455403
Hyperthermia 12.00 10.60 87 165806 12487 42442955
Substance use disorder 12.00 10.60 3 165890 5342 42450100
Mania 11.99 10.60 14 165879 10533 42444909
Post embolisation syndrome 11.99 10.60 6 165887 75 42455367
Intraocular pressure increased 11.99 10.60 5 165888 6428 42449014
Hepatic steatosis 11.96 10.60 43 165850 21405 42434037
Sinus tachycardia 11.94 10.60 128 165765 20525 42434917
Tinnitus 11.91 10.60 65 165828 28873 42426569
Mean platelet volume decreased 11.90 10.60 14 165879 670 42454772
Gastric cancer 11.87 10.60 6 165887 6897 42448545
Nodule 11.87 10.60 19 165874 12515 42442927
No adverse event 11.85 10.60 96 165797 38925 42416517
Inflammation 11.84 10.60 80 165813 33767 42421675
Congenital hypothyroidism 11.84 10.60 4 165889 16 42455426
Productive cough 11.79 10.60 136 165757 51431 42404011
Middle insomnia 11.79 10.60 8 165885 7825 42447617
Bacteroides infection 11.75 10.60 29 165864 2558 42452884
Eye pain 11.73 10.60 31 165862 16999 42438443
Lymphopenia 11.71 10.60 132 165761 21431 42434011
Cyanosis neonatal 11.70 10.60 10 165883 324 42455118
Oral candidiasis 11.70 10.60 96 165797 14309 42441133
Cardiac failure acute 11.70 10.60 22 165871 13611 42441831
Glaucoma 11.66 10.60 9 165884 8239 42447203
Delusion 11.60 10.60 25 165868 14709 42440733
Retroperitoneal neoplasm metastatic 11.59 10.60 3 165890 3 42455439
Lymphocytic oesophagitis 11.59 10.60 3 165890 3 42455439
Anomalous pulmonary venous connection 11.51 10.60 7 165886 131 42455311
Septic shock 11.49 10.60 451 165442 91221 42364221
Radiation mucositis 11.47 10.60 9 165884 258 42455184
Spinal cord injury thoracic 11.46 10.60 7 165886 132 42455310
Escherichia bacteraemia 11.44 10.60 45 165848 5104 42450338
Progressive multifocal leukoencephalopathy 11.39 10.60 17 165876 11519 42443923
Catatonia 11.38 10.60 5 165888 6234 42449208
Pulmonary valve incompetence 11.37 10.60 18 165875 1145 42454297
Mental impairment 11.36 10.60 19 165874 12298 42443144
Orthostatic hypotension 11.33 10.60 71 165822 30499 42424943
Injection site reaction 11.30 10.60 28 165865 15693 42439749
Diaphragmatic rupture 11.29 10.60 4 165889 19 42455423
Klebsiella bacteraemia 11.27 10.60 27 165866 2337 42453105
Haemodialysis 11.26 10.60 14 165879 10246 42445196
Product dispensing error 11.23 10.60 8 165885 7631 42447811
Tendon rupture 11.20 10.60 9 165884 8074 42447368
Periorbital swelling 11.20 10.60 21 165872 1532 42453910
Anger 11.18 10.60 21 165872 12997 42442445
Transaminases increased 11.15 10.60 185 165708 32700 42422742
Hemiplegic migraine 11.13 10.60 3 165890 4 42455438
Starvation 11.08 10.60 12 165881 524 42454918
Proctitis bacterial 11.06 10.60 7 165886 141 42455301
Impaired healing 11.03 10.60 32 165861 17021 42438421
Myocardial ischaemia 11.01 10.60 34 165859 17728 42437714
Catheter site pain 10.99 10.60 22 165871 1685 42453757
Exposure via skin contact 10.98 10.60 3 165890 5035 42450407
Arterial angioplasty 10.97 10.60 5 165888 50 42455392
Cardiac ventricular disorder 10.90 10.60 9 165884 278 42455164
Speech sound disorder 10.80 10.60 7 165886 147 42455295
Neonatal tachypnoea 10.75 10.60 10 165883 363 42455079
Hypertransaminasaemia 10.70 10.60 67 165826 9160 42446282
Congenital hiatus hernia 10.67 10.60 50 165843 6124 42449318
Palmar erythema 10.67 10.60 12 165881 547 42454895
Skin lesion 10.66 10.60 62 165831 27112 42428330
Tympanic membrane perforation 10.60 10.60 11 165882 457 42454985

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3246.99 9.66 4723 382401 312044 109890131
Nausea 1128.14 9.66 7780 379344 1227910 108974265
Vomiting 1028.08 9.66 6055 381069 904620 109297555
Drug ineffective 842.37 9.66 2638 384486 1517902 108684273
Synovitis 837.19 9.66 27 387097 274065 109928110
Constipation 780.74 9.66 2888 384236 354898 109847277
Pemphigus 726.90 9.66 4 387120 214566 109987609
Hand deformity 703.77 9.66 12 387112 218494 109983681
Systemic lupus erythematosus 656.09 9.66 65 387059 254273 109947902
Anti-cyclic citrullinated peptide antibody positive 613.28 9.66 4 387120 181980 110020195
Arthropathy 609.37 9.66 131 386993 287391 109914784
Neutropenia 606.47 9.66 2758 384366 371862 109830313
Duodenal ulcer perforation 559.24 9.66 13 387111 177687 110024488
Diarrhoea 559.09 9.66 6265 380859 1133240 109068935
Pericarditis 554.78 9.66 60 387064 219054 109983121
Helicobacter infection 537.78 9.66 23 387101 181854 110020321
Glossodynia 518.16 9.66 79 387045 221925 109980250
Therapeutic product effect decreased 504.22 9.66 118 387006 244198 109957977
Cytokine release syndrome 494.27 9.66 885 386239 69421 110132754
Thrombocytopenia 487.31 9.66 2462 384662 346423 109855752
Dehydration 472.46 9.66 2085 385039 277426 109924749
Wound 470.58 9.66 120 387004 234317 109967858
Serotonin syndrome 468.62 9.66 785 386339 58368 110143807
Joint swelling 457.04 9.66 526 386598 442319 109759856
Drug abuse 453.15 9.66 47 387077 177364 110024811
Muscle injury 448.18 9.66 9 387115 140798 110061377
Aplastic anaemia 447.89 9.66 487 386637 23821 110178354
Mucosal inflammation 439.30 9.66 1012 386112 95129 110107046
Impaired healing 428.37 9.66 84 387040 196633 110005542
Folliculitis 419.08 9.66 48 387076 167605 110034570
Type 2 diabetes mellitus 416.01 9.66 62 387062 177170 110025005
Rheumatic fever 411.44 9.66 3 387121 122576 110079599
Psoriatic arthropathy 392.40 9.66 102 387022 196659 110005516
Torsade de pointes 367.10 9.66 424 386700 22176 110179999
C-reactive protein abnormal 362.65 9.66 23 387101 129672 110072503
Therapeutic product effect incomplete 358.80 9.66 167 386957 223638 109978537
Sepsis 358.41 9.66 2163 384961 325183 109876992
Mobility decreased 351.04 9.66 197 386927 237225 109964950
Treatment failure 350.59 9.66 274 386850 276960 109925215
Pyrexia 348.11 9.66 4728 382396 893537 109308638
Fibromyalgia 347.75 9.66 85 387039 170824 110031351
Electrocardiogram QT prolonged 345.77 9.66 1000 386124 107960 110094215
Irritable bowel syndrome 345.39 9.66 76 387048 164139 110038036
Abdominal pain 336.17 9.66 2998 384126 509991 109692184
Fatigue 335.10 9.66 6042 381082 1209916 108992259
Joint range of motion decreased 333.63 9.66 24 387100 121808 110080367
Sleep disorder due to general medical condition, insomnia type 331.31 9.66 8 387116 105635 110096540
Neuropathy peripheral 330.21 9.66 1373 385751 177904 110024271
Arthralgia 323.19 9.66 1517 385607 778115 109424060
Death 320.45 9.66 3796 383328 695073 109507102
Facet joint syndrome 317.34 9.66 4 387120 96824 110105351
Musculoskeletal stiffness 316.93 9.66 307 386817 279515 109922660
Flushing 306.45 9.66 934 386190 103802 110098373
White blood cell count decreased 291.82 9.66 1578 385546 227812 109974363
Plasma cell myeloma 273.81 9.66 650 386474 62286 110139889
Inflammation 273.38 9.66 169 386955 193069 110009106
Disease progression 269.81 9.66 1617 385507 242417 109959758
Toxicity to various agents 264.69 9.66 833 386291 479722 109722453
Swelling 264.02 9.66 518 386606 350523 109851652
Condition aggravated 259.95 9.66 1509 385615 733327 109468848
Chills 259.49 9.66 1336 385788 189244 110012931
Ventricular fibrillation 258.85 9.66 495 386629 40818 110161357
Erythema 257.99 9.66 1826 385298 289621 109912554
Osteoarthritis 257.95 9.66 160 386964 182463 110019712
Hypoxia 256.80 9.66 1015 386109 128500 110073675
Breast cancer stage III 256.10 9.66 4 387120 79113 110123062
Liver injury 255.71 9.66 103 387021 150310 110051865
Lip dry 246.75 9.66 30 387094 100053 110102122
Contraindicated product administered 246.16 9.66 304 386820 247963 109954212
Wheezing 243.26 9.66 322 386802 254908 109947267
Weight increased 236.30 9.66 720 386404 418924 109783251
Febrile bone marrow aplasia 232.07 9.66 296 386828 17169 110185006
Peripheral venous disease 229.07 9.66 17 387107 84100 110118075
Hepatic enzyme increased 228.14 9.66 489 386635 320403 109881772
Drug intolerance 222.13 9.66 707 386417 405805 109796370
Completed suicide 219.74 9.66 317 386807 242064 109960111
Obesity 216.17 9.66 64 387060 113287 110088888
Blood cholesterol increased 212.35 9.66 200 386924 184585 110017590
Blister 211.46 9.66 292 386832 227084 109975091
Ill-defined disorder 209.89 9.66 146 386978 156707 110045468
Back pain 206.82 9.66 2096 385028 368900 109833275
Anaemia 198.45 9.66 2848 384276 544238 109657937
Hyperhidrosis 196.16 9.66 1224 385900 186074 110016101
Abdominal discomfort 190.88 9.66 721 386403 393137 109809038
Hospice care 189.26 9.66 226 386898 12247 110189928
Neutrophil count decreased 185.33 9.66 877 386247 120064 110082111
Grip strength decreased 183.66 9.66 30 387094 80144 110122031
Encephalopathy 182.78 9.66 662 386462 80393 110121782
Injury 178.92 9.66 214 386910 177051 110025124
Neutropenic sepsis 177.57 9.66 356 386768 30390 110171785
Rheumatoid arthritis 172.93 9.66 508 386616 299105 109903070
Wound infection 172.40 9.66 61 387063 96404 110105771
Red blood cell sedimentation rate increased 171.32 9.66 33 387091 78269 110123906
Appendicolith 169.87 9.66 229 386895 14026 110188149
Small intestinal obstruction 168.42 9.66 358 386766 31855 110170320
Anaphylactic reaction 166.59 9.66 817 386307 113483 110088692
Lower respiratory tract infection 165.73 9.66 379 386745 242727 109959448
Tachycardia 161.92 9.66 1351 385773 225294 109976881
Gait inability 160.95 9.66 144 386980 136232 110065943
Musculoskeletal pain 159.41 9.66 246 386878 182777 110019398
Nasopharyngitis 158.53 9.66 775 386349 393586 109808589
Hypercholesterolaemia 158.01 9.66 60 387064 90777 110111398
Hypokalaemia 157.77 9.66 1137 385987 181311 110020864
Intentional product use issue 155.97 9.66 403 386721 247503 109954672
Pancytopenia 154.30 9.66 1258 385866 208355 109993820
Colitis 153.87 9.66 738 386386 101585 110100590
Pulmonary fibrosis 153.17 9.66 83 387041 101959 110100216
Sciatica 152.63 9.66 66 387058 92333 110109842
Cardiac arrest 150.36 9.66 1191 385933 195562 110006613
Discomfort 149.38 9.66 331 386793 214376 109987799
Loss of personal independence in daily activities 143.15 9.66 189 386935 149831 110052344
Lower limb fracture 142.83 9.66 43 387081 75305 110126870
Platelet count decreased 139.05 9.66 1324 385800 229119 109973056
Dislocation of vertebra 138.28 9.66 3 387121 43718 110158457
Appendicitis 138.16 9.66 307 386817 28157 110174018
Ascites 137.83 9.66 667 386457 92141 110110034
Osteoporosis 136.59 9.66 67 387057 87085 110115090
Lung disorder 134.97 9.66 266 386858 179781 110022394
Decreased appetite 129.63 9.66 2363 384761 473483 109728692
Transfusion 129.61 9.66 280 386844 25192 110176983
Bone erosion 127.32 9.66 9 387115 46362 110155813
Blepharospasm 126.81 9.66 20 387104 54831 110147344
Anaphylactic shock 123.93 9.66 430 386694 51116 110151059
Intentional overdose 123.31 9.66 170 386954 132331 110069844
Malignant neoplasm progression 122.74 9.66 1037 386087 173530 110028645
Road traffic accident 122.47 9.66 117 387007 107281 110094894
Drug resistance 120.73 9.66 25 387099 56349 110145826
Knee arthroplasty 119.65 9.66 39 387085 64909 110137266
Adjustment disorder with depressed mood 119.11 9.66 9 387115 43874 110158301
X-ray abnormal 119.07 9.66 3 387121 38114 110164061
Autoimmune disorder 117.71 9.66 41 387083 65442 110136733
Asthenia 116.62 9.66 3197 383927 685802 109516373
Drug hypersensitivity 114.36 9.66 1027 386097 453063 109749112
Pleural effusion 112.68 9.66 1032 386092 176677 110025498
Carotid artery thrombosis 112.06 9.66 153 386971 9485 110192690
Hypotension 111.65 9.66 2508 384616 521341 109680834
Liver disorder 111.11 9.66 205 386919 142038 110060137
Hip arthroplasty 111.09 9.66 29 387095 55784 110146391
Foetal death 110.19 9.66 200 386924 15845 110186330
Hyponatraemia 106.80 9.66 1199 385925 216454 109985721
Neurologic neglect syndrome 105.69 9.66 146 386978 9152 110193023
Neoplasm progression 105.26 9.66 477 386647 64118 110138057
Rhabdomyolysis 103.71 9.66 163 386961 120238 110081937
Lupus-like syndrome 103.62 9.66 11 387113 40781 110161394
Ventricular tachycardia 103.19 9.66 397 386727 49612 110152563
Laryngospasm 102.98 9.66 103 387021 4565 110197610
Food allergy 102.33 9.66 220 386904 19728 110182447
Myocardial infarction 102.06 9.66 338 386786 191745 110010430
Rash maculo-papular 101.40 9.66 521 386603 73701 110128474
Peripheral swelling 101.19 9.66 915 386209 403119 109799056
Therapeutic response decreased 101.12 9.66 113 387011 96386 110105789
Onychomadesis 100.41 9.66 19 387105 45644 110156531
Temperature regulation disorder 99.93 9.66 169 386955 12657 110189518
Foot deformity 98.79 9.66 24 387100 48456 110153719
Aphasia 98.64 9.66 439 386685 58558 110143617
Failure to thrive 98.09 9.66 173 386951 13401 110188774
Arterial occlusive disease 96.60 9.66 184 386940 15124 110187051
C-reactive protein increased 96.58 9.66 413 386711 217506 109984669
Bursitis 96.45 9.66 193 386931 129725 110072450
Clonus 96.30 9.66 135 386989 8581 110193594
Hypophosphataemia 96.15 9.66 295 386829 32887 110169288
Gangrene 95.31 9.66 190 386934 16151 110186024
Neutropenic colitis 95.24 9.66 129 386995 7936 110194239
Finger deformity 95.14 9.66 5 387119 33087 110169088
Exostosis 95.13 9.66 22 387102 45934 110156241
Retching 95.12 9.66 231 386893 22451 110179724
Leukopenia 94.79 9.66 865 386259 147926 110054249
Contusion 94.62 9.66 457 386667 232904 109969271
Adjustment disorder 94.60 9.66 150 386974 10645 110191530
Full blood count decreased 94.53 9.66 287 386837 31812 110170363
Dysphagia 94.35 9.66 886 386238 152714 110049461
Medication error 94.26 9.66 139 386985 105227 110096948
Therapy non-responder 94.16 9.66 262 386862 157045 110045130
Blood phosphorus increased 94.12 9.66 189 386935 16151 110186024
Intentional self-injury 92.79 9.66 11 387113 37418 110164757
Unresponsive to stimuli 90.81 9.66 453 386671 63337 110138838
Eating disorder 90.03 9.66 275 386849 30583 110171592
Chest discomfort 89.54 9.66 967 386157 172881 110029294
Onychomycosis 89.18 9.66 14 387110 38517 110163658
Type I hypersensitivity 89.15 9.66 111 387013 6282 110195893
Live birth 88.61 9.66 68 387056 69416 110132759
Clostridium difficile colitis 88.26 9.66 345 386779 43433 110158742
Palmar-plantar erythrodysaesthesia syndrome 87.38 9.66 329 386795 40696 110161479
Sleep disorder 87.09 9.66 378 386746 198266 110003909
Oedema 87.00 9.66 408 386716 209568 109992607
Oxygen saturation decreased 86.40 9.66 885 386239 156097 110046078
Injection site reaction 86.20 9.66 111 387013 88959 110113216
Aplasia 85.58 9.66 121 387003 7752 110194423
Pulmonary embolism 84.63 9.66 1134 385990 213340 109988835
Pneumonia 83.95 9.66 3811 383313 872903 109329272
Suicide attempt 83.45 9.66 146 386978 103248 110098927
Alopecia 82.02 9.66 848 386276 363905 109838270
Injection site pain 81.44 9.66 333 386791 177589 110024586
Nail disorder 81.43 9.66 51 387073 57884 110144291
Epilepsy 81.33 9.66 141 386983 100068 110102107
Night sweats 81.05 9.66 222 386902 133761 110068414
Immune effector cell-associated neurotoxicity syndrome 80.43 9.66 167 386957 14615 110187560
Asthma 79.40 9.66 531 386593 249760 109952415
Sopor 78.69 9.66 16 387108 36530 110165645
Neuralgia 78.25 9.66 357 386767 48121 110154054
Oculogyric crisis 78.07 9.66 81 387043 3751 110198424
Back injury 78.05 9.66 34 387090 47365 110154810
Hepatic function abnormal 77.75 9.66 120 387004 89175 110113000
Overdose 77.20 9.66 490 386634 233304 109968871
Oral pain 77.05 9.66 297 386827 37147 110165028
Drug tolerance decreased 76.62 9.66 5 387119 27535 110174640
Bacterial infection 75.79 9.66 341 386783 45695 110156480
Personality disorder 73.36 9.66 148 386976 12689 110189486
Nephrolithiasis 73.23 9.66 439 386685 65773 110136402
Hypomagnesaemia 73.10 9.66 410 386714 59960 110142215
Bacteraemia 72.81 9.66 318 386806 42072 110160103
Long QT syndrome 72.40 9.66 106 387018 7012 110195163
Lymphoid tissue hypoplasia 72.05 9.66 54 387070 1611 110200564
Dysgeusia 71.11 9.66 454 386670 69531 110132644
Delirium 70.76 9.66 239 386885 134786 110067389
Sinusitis 70.33 9.66 681 386443 296007 109906168
Clostridium difficile infection 69.87 9.66 364 386760 51765 110150410
Thymus hypoplasia 69.21 9.66 53 387071 1634 110200541
Sensory loss 69.05 9.66 198 386926 21259 110180916
Drug dependence 68.98 9.66 45 387079 49975 110152200
Atelectasis 68.95 9.66 283 386841 36429 110165746
Hypophagia 68.15 9.66 364 386760 52262 110149913
Dyspnoea 67.86 9.66 4618 382506 1102254 109099921
Analgesic therapy 67.71 9.66 104 387020 7180 110194995
Sleep disorder therapy 67.11 9.66 105 387019 7366 110194809
Epistaxis 67.04 9.66 725 386399 129647 110072528
Product label confusion 66.56 9.66 3 387121 22674 110179501
Lactic acidosis 66.24 9.66 141 386983 92670 110109505
Prescribed underdose 65.39 9.66 79 387045 65095 110137080
Hyperphosphataemia 64.64 9.66 163 386961 16218 110185957
Computerised tomogram thorax abnormal 64.12 9.66 63 387061 2732 110199443
Computerised tomogram thorax 64.08 9.66 33 387091 493 110201682
Ventricular tachyarrhythmia 63.67 9.66 33 387091 500 110201675
Impaired gastric emptying 63.10 9.66 142 386982 13133 110189042
Blood pressure diastolic abnormal 62.98 9.66 8 387116 25807 110176368
Drug-induced liver injury 62.59 9.66 213 386911 119854 110082321
Pain in extremity 62.11 9.66 1267 385857 485851 109716324
Desmoplastic small round cell tumour 61.92 9.66 21 387103 97 110202078
Joint stiffness 61.82 9.66 87 387037 67156 110135019
Pregnancy 61.35 9.66 53 387071 51014 110151161
Dystonia 60.92 9.66 214 386910 25591 110176584
Cardiogenic shock 60.77 9.66 376 386748 56962 110145213
Mental status changes 60.42 9.66 465 386659 75657 110126518
Blood pressure fluctuation 60.07 9.66 106 387018 74718 110127457
Affect lability 60.00 9.66 172 386952 18465 110183710
Adverse event 58.80 9.66 190 386934 108619 110093556
Maternal exposure during pregnancy 58.74 9.66 589 386535 254294 109947881
Intestinal obstruction 58.28 9.66 352 386772 52875 110149300
Embolism 58.04 9.66 156 386968 16133 110186042
Schizophrenia 57.78 9.66 5 387119 21821 110180354
Coma 57.51 9.66 215 386909 117654 110084521
Neutrophil count abnormal 57.46 9.66 80 387044 5052 110197123
Bronchospasm 55.92 9.66 232 386892 30007 110172168
Platelet transfusion 55.91 9.66 59 387065 2787 110199388
Renal impairment 55.72 9.66 408 386716 188037 110014138
Depression 55.55 9.66 779 386345 316556 109885619
Rheumatoid nodule 55.55 9.66 4 387120 20292 110181883
Blood pressure systolic abnormal 55.37 9.66 10 387114 24840 110177335
Blood pressure systolic increased 55.21 9.66 131 386993 82860 110119315
Thrombosis 54.36 9.66 601 386523 108061 110094114
Joint dislocation 54 9.66 26 387098 34164 110168011
Product quality issue 53.86 9.66 119 387005 77180 110124995
Vascular device infection 53.75 9.66 153 386971 16359 110185816
Skin haemorrhage 53.62 9.66 200 386924 24627 110177548
Neurotoxicity 53.34 9.66 290 386834 41917 110160258
Myasthenia gravis 53.05 9.66 181 386943 21330 110180845
Breast cancer stage II 53.02 9.66 15 387109 27360 110174815
Injection site swelling 52.87 9.66 84 387040 61706 110140469
Anaesthetic complication neurological 52.66 9.66 37 387087 996 110201179
Sinus tachycardia 52.44 9.66 300 386824 44193 110157982
Hair colour changes 52.21 9.66 73 387051 4628 110197547
Tumour lysis syndrome 52.09 9.66 230 386894 30571 110171604
Hot flush 51.64 9.66 402 386722 65634 110136541
Drug therapy 51.49 9.66 92 387032 7199 110194976
Urinary tract infection 51.14 9.66 1500 385624 324782 109877393
Device expulsion 51.11 9.66 22 387102 30869 110171306
Acute respiratory failure 50.72 9.66 443 386681 74817 110127358
Motor dysfunction 50.55 9.66 194 386930 24212 110177963
Osteonecrosis of jaw 50.55 9.66 56 387068 47961 110154214
Porphyria acute 50.55 9.66 4 387120 18776 110183399
Segmental diverticular colitis 50.44 9.66 20 387104 154 110202021
Poisoning deliberate 49.95 9.66 15 387109 26316 110175859
Insomnia 49.86 9.66 925 386199 359665 109842510
Disseminated aspergillosis 49.77 9.66 52 387072 2428 110199747
Laryngitis 49.76 9.66 45 387079 42366 110159809
Interstitial lung disease 49.67 9.66 285 386839 139049 110063126
Underdose 49.26 9.66 92 387032 63462 110138713
Injection site erythema 48.45 9.66 168 386956 94008 110108167
Memory impairment 48.38 9.66 448 386676 196496 110005679
Hypoaesthesia 48.27 9.66 791 386333 313432 109888743
Maternal exposure timing unspecified 47.81 9.66 8 387116 21005 110181170
Coordination abnormal 47.79 9.66 195 386929 25033 110177142
Basal cell carcinoma 47.44 9.66 53 387071 45217 110156958
Abdominal distension 47.36 9.66 869 386255 174234 110027941
Vasculitis 47.16 9.66 34 387090 35839 110166336
Arthritis 47.10 9.66 368 386756 167218 110034957
Cyclic vomiting syndrome 46.97 9.66 19 387105 155 110202020
Hepatocellular injury 46.89 9.66 321 386803 50321 110151854
Aggression 46.52 9.66 85 387039 59125 110143050
Blood bilirubin increased 46.52 9.66 438 386686 75534 110126641
Proctalgia 46.48 9.66 126 386998 13096 110189079
Hemiplegia 46.29 9.66 180 386944 22602 110179573
Stridor 46.15 9.66 85 387039 6810 110195365
Blood potassium decreased 45.45 9.66 335 386789 53779 110148396
Hypervolaemia 44.91 9.66 312 386812 49148 110153027
Frequent bowel movements 44.90 9.66 116 387008 71274 110130901
Psychotic disorder 44.77 9.66 68 387056 50869 110151306
Bone pain 44.73 9.66 385 386739 64748 110137427
Colitis ulcerative 44.70 9.66 131 386993 77232 110124943
Pneumonitis 44.28 9.66 436 386688 76095 110126080
Hepatic cirrhosis 43.99 9.66 108 387016 67518 110134657
Calcium ionised decreased 43.93 9.66 28 387096 638 110201537
Sinus congestion 43.84 9.66 217 386907 30242 110171933
Troponin increased 43.51 9.66 213 386911 29553 110172622
Carbohydrate antigen 125 increased 43.41 9.66 49 387075 2498 110199677
Product use issue 43.26 9.66 799 386325 310896 109891279
Immunodeficiency 43.26 9.66 258 386866 38580 110163595
Tremor 43.21 9.66 969 386155 201263 110000912
Poisoning 43.19 9.66 24 387100 29081 110173094
Gait disturbance 43.16 9.66 699 386425 277509 109924666
Tracheal deviation 43.09 9.66 21 387103 277 110201898
Hereditary angioedema 43.04 9.66 84 387040 7030 110195145
Cerebral infarction 42.92 9.66 72 387052 51766 110150409
Enteritis 42.78 9.66 156 386968 19000 110183175
Negative pressure pulmonary oedema 42.70 9.66 28 387096 671 110201504
Cough 42.15 9.66 1998 385126 459643 109742532
Prostate cancer 41.75 9.66 42 387082 37599 110164576
Monocyte chemotactic protein-1 increased 41.72 9.66 22 387102 346 110201829
Macular degeneration 41.70 9.66 12 387112 21647 110180528
Skin exfoliation 41.67 9.66 480 386644 87171 110115004
Urticaria 41.60 9.66 826 386298 318031 109884144
Feeling hot 41.57 9.66 495 386629 90611 110111564
SARS-CoV-2 test negative 41.17 9.66 44 387080 2109 110200066
Heart rate decreased 40.99 9.66 150 386974 82606 110119569
Coronary artery disease 40.98 9.66 122 387002 71568 110130607
Anal inflammation 40.82 9.66 47 387077 2449 110199726
Lupus vasculitis 40.81 9.66 26 387098 592 110201583
Ageusia 40.56 9.66 156 386968 19489 110182686
Acute kidney injury 40.55 9.66 2661 384463 632769 109569406
Treatment noncompliance 40.45 9.66 126 386998 72864 110129311
Gastrointestinal injury 40.17 9.66 41 387083 1862 110200313
Wrong technique in product usage process 39.63 9.66 164 386960 87184 110114991
Rectal haemorrhage 39.61 9.66 251 386873 119582 110082593
Alpha tumour necrosis factor increased 39.39 9.66 22 387102 390 110201785
Blood creatine phosphokinase increased 39.20 9.66 128 386996 72949 110129226
Escherichia bacteraemia 38.93 9.66 100 387024 10064 110192111
Septic shock 38.91 9.66 771 386353 156757 110045418
Red blood cell count decreased 38.84 9.66 377 386747 65546 110136629
Gastrooesophageal reflux disease 38.56 9.66 423 386701 179553 110022622
Blood magnesium decreased 38.23 9.66 155 386969 19841 110182334
Disease recurrence 38.05 9.66 99 387025 60685 110141490
Dilatation intrahepatic duct acquired 37.95 9.66 28 387096 815 110201360
Dry skin 37.92 9.66 558 386566 107095 110095080
Adverse drug reaction 37.57 9.66 216 386908 105343 110096832
Hemiparesis 37.56 9.66 273 386851 43630 110158545
Product complaint 37.54 9.66 3 387121 13969 110188206
Pedal pulse abnormal 37.44 9.66 18 387106 230 110201945
Dysentery 37.37 9.66 34 387090 1337 110200838
Amnesia 37.35 9.66 216 386908 105192 110096983
Dysarthria 37.05 9.66 454 386670 83667 110118508
Osteonecrosis 37.03 9.66 38 387086 33703 110168472
Bone density decreased 36.74 9.66 6 387118 16036 110186139
Deep vein thrombosis 36.70 9.66 691 386433 139196 110062979
Toxic erythema of chemotherapy 36.69 9.66 21 387103 391 110201784
Sleep disorder due to a general medical condition 36.49 9.66 80 387044 52032 110150143
Obstructive airways disorder 36.48 9.66 66 387058 46083 110156092
Sedation complication 36.43 9.66 12 387112 19843 110182332
Drug eruption 36.25 9.66 84 387040 53575 110148600
Sinus disorder 36.19 9.66 217 386907 32511 110169664
Sneezing 35.96 9.66 213 386911 31771 110170404
Anaphylactoid reaction 35.84 9.66 76 387048 6750 110195425
Throat tightness 35.73 9.66 220 386904 33269 110168906
Sense of oppression 35.69 9.66 36 387088 1612 110200563
Respiratory distress 35.39 9.66 383 386741 68491 110133684
Procedural nausea 35.19 9.66 31 387093 1168 110201007
Multiple-drug resistance 35.12 9.66 3 387121 13232 110188943
Injection site pruritus 34.82 9.66 80 387044 51178 110150997
Ileus 34.78 9.66 205 386919 30524 110171651
Enterocolitis 34.74 9.66 145 386979 18804 110183371
Electrocardiogram QRS complex 34.73 9.66 8 387116 3 110202172
Antacid therapy 34.70 9.66 66 387058 5418 110196757
Infection 34.32 9.66 985 386139 361215 109840960
Malnutrition 34.18 9.66 187 386937 27092 110175083
Hyperkalaemia 34.17 9.66 307 386817 135489 110066686
Myelosuppression 34.14 9.66 192 386932 94148 110108027
Paranoia 33.86 9.66 18 387106 22356 110179819
Apnoea 33.84 9.66 115 387009 13524 110188651
Drug ineffective for unapproved indication 33.69 9.66 216 386908 102622 110099553
Long QT syndrome congenital 33.58 9.66 15 387109 160 110202015
Anticoagulant therapy 33.29 9.66 64 387060 5297 110196878
Pulse absent 33.28 9.66 101 387023 11191 110190984
Post transplant lymphoproliferative disorder 33.27 9.66 7 387117 15606 110186569
Streptococcal bacteraemia 33.08 9.66 59 387065 4610 110197565
Drug use disorder 33.03 9.66 11 387113 18063 110184112
Blood uric acid increased 32.87 9.66 156 386968 21373 110180802
Upper respiratory tract infection 32.84 9.66 644 386480 130684 110071491
Seizure 32.79 9.66 1010 386114 220175 109982000
Pemphigoid 32.66 9.66 14 387110 19693 110182482
Accidental exposure to product 32.42 9.66 80 387044 49928 110152247
Cognitive disorder 32.27 9.66 177 386947 87334 110114841
Product used for unknown indication 32.16 9.66 37 387087 1926 110200249
Altered state of consciousness 31.56 9.66 100 387024 57526 110144649
Tumour pain 31.37 9.66 45 387079 2922 110199253
Left atrial hypertrophy 31.25 9.66 11 387113 58 110202117
Dementia 31.13 9.66 39 387085 31634 110170541
Therapy partial responder 31.13 9.66 51 387073 37010 110165165
Hyperaemia 31.11 9.66 51 387073 3722 110198453
Muscle spasticity 31.11 9.66 224 386900 35691 110166484
Cytomegalovirus infection 30.87 9.66 93 387031 54351 110147824
Streptococcal sepsis 30.82 9.66 60 387064 5012 110197163
Fracture 30.67 9.66 25 387099 24763 110177412
Melaena 30.02 9.66 131 386993 68626 110133549
Respiratory tract congestion 30.01 9.66 198 386926 30659 110171516
Pneumothorax 29.95 9.66 219 386905 35066 110167109
Labelled drug-drug interaction medication error 29.95 9.66 35 387089 29267 110172908
Rash erythematous 29.94 9.66 427 386697 81405 110120770
Phrenic nerve paralysis 29.87 9.66 21 387103 566 110201609
Hypoglycaemia 29.86 9.66 261 386863 115843 110086332
Hepatic cytolysis 29.62 9.66 309 386815 54744 110147431
Tenosynovitis 29.60 9.66 10 387114 16273 110185902
Hyperthermia 29.52 9.66 150 386974 21122 110181053
Nightmare 29.51 9.66 235 386889 38628 110163547
Premature delivery 29.46 9.66 196 386928 30436 110171739
Abdominal pain lower 29.17 9.66 227 386897 37056 110165119
Extravasation 29.06 9.66 57 387067 4788 110197387
Cardiac murmur 29.05 9.66 26 387098 24602 110177573
Bronchiectasis 29.02 9.66 52 387072 36441 110165734
Electrocardiogram T wave biphasic 29.02 9.66 15 387109 226 110201949
Mechanical ventilation complication 28.98 9.66 23 387101 748 110201427
Diabetes mellitus inadequate control 28.92 9.66 37 387087 29738 110172437
Transplant rejection 28.90 9.66 26 387098 24541 110177634
Blood alkaline phosphatase increased 28.75 9.66 377 386747 70558 110131617
Opisthotonus 28.59 9.66 23 387101 763 110201412
Electrocardiogram QT shortened 28.53 9.66 16 387108 286 110201889
Therapy interrupted 28.41 9.66 283 386841 49539 110152636
Arteriospasm coronary 28.34 9.66 83 387041 9017 110193158
Aspartate aminotransferase increased 28.32 9.66 747 386377 159189 110042986
Transmission of an infectious agent via product 28.31 9.66 14 387110 191 110201984
Respiratory disorder 28.21 9.66 141 386983 71241 110130934
Pancreatitis acute 28.16 9.66 329 386795 59945 110142230
Pseudomonal bacteraemia 28.15 9.66 53 387071 4318 110197857
Vascular access site thrombosis 27.99 9.66 12 387112 115 110202060
Cellulitis 27.92 9.66 607 386517 125409 110076766
Arteriosclerosis coronary artery 27.89 9.66 28 387096 25090 110177085
Disability 27.88 9.66 39 387085 30184 110171991
Pulseless electrical activity 27.48 9.66 124 387000 16633 110185542
Fall 27.46 9.66 1782 385342 601700 109600475
Cancer pain 27.37 9.66 68 387056 6704 110195471
Atrial fibrillation 27.29 9.66 1022 386102 228620 109973555
Hyperbilirubinaemia 26.98 9.66 192 386932 30479 110171696
Neutropenic infection 26.94 9.66 44 387080 3201 110198974
Dyspepsia 26.64 9.66 489 386635 190476 110011699
Laryngeal discomfort 26.56 9.66 22 387102 761 110201414
Monoclonal immunoglobulin increased 26.56 9.66 20 387104 601 110201574
Myocardial reperfusion injury 26.46 9.66 12 387112 133 110202042
Product substitution issue 26.43 9.66 25 387099 23036 110179139
Glaucoma 26.29 9.66 24 387100 22493 110179682
Ventilation perfusion mismatch 26.22 9.66 22 387102 775 110201400
Blood pressure diastolic decreased 26.03 9.66 54 387070 35831 110166344
Panniculitis 25.94 9.66 11 387113 15571 110186604
Substance abuse 25.73 9.66 6 387118 12457 110189718
Immune-mediated hepatitis 25.67 9.66 66 387058 6645 110195530
Interleukin level increased 25.63 9.66 30 387094 1591 110200584
Cestode infection 25.57 9.66 15 387109 293 110201882
Adverse reaction 25.54 9.66 40 387084 29554 110172621
Illness 25.52 9.66 417 386707 81754 110120421
Glycosylated haemoglobin increased 25.47 9.66 27 387097 23592 110178583
Injection site bruising 25.33 9.66 93 387031 51170 110151005
Procedural vomiting 25.30 9.66 24 387100 996 110201179
Lymphocyte count decreased 25.23 9.66 309 386815 56934 110145241
Erectile dysfunction 25.17 9.66 17 387107 18539 110183636
Administration site inflammation 25.11 9.66 10 387114 78 110202097
Alanine aminotransferase increased 25.10 9.66 831 386293 182942 110019233
Parainfluenzae virus infection 25.06 9.66 67 387057 6907 110195268
Pain 24.88 9.66 2945 384179 952010 109250165
End stage renal disease 24.79 9.66 144 386980 21329 110180846
Nail bed inflammation 24.78 9.66 33 387091 1997 110200178
Tendonitis 24.73 9.66 33 387091 26050 110176125
Large intestinal obstruction 24.69 9.66 47 387077 3861 110198314
Haemorrhoids 24.57 9.66 211 386913 35461 110166714
Drug dose omission by device 24.56 9.66 10 387114 14506 110187669
Electrolyte imbalance 24.45 9.66 217 386907 36811 110165364
Skin ulcer 24.42 9.66 127 386997 63518 110138657
Seizure like phenomena 24.32 9.66 36 387088 2405 110199770
Hospitalisation 24.22 9.66 662 386462 141831 110060344
Nasal polyps 24.18 9.66 8 387116 13192 110188983
Iron deficiency 24.06 9.66 128 386996 18348 110183827
Pseudomonal sepsis 23.98 9.66 78 387046 8968 110193207
Female genital tract fistula 23.97 9.66 14 387110 16505 110185670
Venoocclusive liver disease 23.81 9.66 111 387013 15096 110187079
Rebound effect 23.78 9.66 11 387113 14795 110187380
Food aversion 23.50 9.66 29 387095 1626 110200549
Hydronephrosis 23.48 9.66 138 386986 20527 110181648
Cardio-respiratory arrest 23.48 9.66 551 386573 115285 110086890
Supraventricular tachycardia 23.32 9.66 156 386968 24266 110177909
Cervix neoplasm 23.20 9.66 12 387112 181 110201994
Immune reconstitution inflammatory syndrome 23.20 9.66 14 387110 16212 110185963
Drug clearance decreased 22.93 9.66 47 387077 4075 110198100
Suicidal ideation 22.92 9.66 214 386910 93723 110108452
Respiratory syncytial virus infection 22.88 9.66 106 387018 14378 110187797
Cystitis 22.75 9.66 341 386783 65695 110136480
Skin candida 22.72 9.66 34 387090 2294 110199881
Posterior reversible encephalopathy syndrome 22.65 9.66 199 386925 33662 110168513
Palmar erythema 22.61 9.66 34 387090 2304 110199871
Eczema 22.59 9.66 154 386970 72139 110130036
Product dose omission issue 22.58 9.66 1359 385765 320423 109881752
Blood pressure measurement 22.51 9.66 17 387107 513 110201662
Gastroenteropancreatic neuroendocrine tumour disease 22.51 9.66 9 387115 71 110202104
Pancreatitis 22.49 9.66 456 386668 93077 110109098
Fluid replacement 22.45 9.66 22 387102 951 110201224
Lymphopenia 22.34 9.66 227 386897 39943 110162232
Blood creatinine increased 22.23 9.66 816 386308 182073 110020102
Oropharyngeal discomfort 22.14 9.66 83 387041 10244 110191931
Incorrect dose administered 22.03 9.66 244 386880 103397 110098778
Peripheral sensory neuropathy 22.02 9.66 116 387008 16564 110185611
Dry mouth 22.02 9.66 532 386592 199416 110002759
Oxygen saturation immeasurable 21.98 9.66 9 387115 76 110202099
Vascular access site infection 21.93 9.66 11 387113 155 110202020
Pulmonary tuberculosis 21.89 9.66 3 387121 9136 110193039
Drug interaction 21.89 9.66 1482 385642 498701 109703474
Orthostatic hypotension 21.77 9.66 139 386985 66110 110136065
Capillary leak syndrome 21.67 9.66 51 387073 4857 110197318
Skin necrosis 21.66 9.66 26 387098 21486 110180689
Pathogen resistance 21.64 9.66 18 387106 17654 110184521
Tachypnoea 21.61 9.66 222 386902 39173 110163002
Chronic sinusitis 21.55 9.66 34 387090 25050 110177125
Burkholderia cepacia complex infection 21.47 9.66 16 387108 473 110201702
Ear infection 21.45 9.66 130 386994 62602 110139573
Thrombocytopenic purpura 21.02 9.66 38 387086 3001 110199174
Administration site oedema 20.88 9.66 7 387117 31 110202144
Activated partial thromboplastin time prolonged 20.84 9.66 142 386982 22226 110179949
Gynaecomastia 20.75 9.66 4 387120 9486 110192689
Cytopenia 20.67 9.66 178 386946 29938 110172237
International normalised ratio increased 20.61 9.66 199 386925 86573 110115602
Spondylitis 20.54 9.66 7 387117 11331 110190844
Cyanosis 20.52 9.66 176 386948 29565 110172610
Infusion site reaction 20.46 9.66 19 387105 17663 110184512
Anaphylactoid shock 20.37 9.66 21 387103 965 110201210
Periorbital cellulitis 20.33 9.66 22 387102 1070 110201105
Rash macular 20.28 9.66 216 386908 38470 110163705
Stress cardiomyopathy 20.24 9.66 109 387015 15697 110186478
Device adhesion issue 20.20 9.66 4 387120 9306 110192869
Blood calcium increased 20.19 9.66 120 387004 17920 110184255
Fluid retention 20.17 9.66 452 386672 93855 110108320
Parenteral nutrition 20.11 9.66 20 387104 880 110201295
Myoclonus 20.07 9.66 190 386934 32808 110169367
Enterocolitis infectious 20.03 9.66 40 387084 3404 110198771
Post procedural hypotension 19.99 9.66 9 387115 98 110202077
Exposure to toxic agent 19.97 9.66 10 387114 12848 110189327
Device related infection 19.95 9.66 219 386905 39300 110162875
Colitis microscopic 19.94 9.66 11 387113 13383 110188792
Moaning 19.87 9.66 25 387099 1430 110200745
Fixed eruption 19.81 9.66 45 387079 4187 110197988
Testicular germ cell cancer metastatic 19.81 9.66 8 387116 65 110202110
Acute pulmonary oedema 19.63 9.66 114 387010 16882 110185293
Systemic inflammatory response syndrome 19.54 9.66 94 387030 12949 110189226
Intestinal perforation 19.53 9.66 133 386991 20811 110181364
Pericardial effusion 19.53 9.66 295 386829 56922 110145253
Alcohol poisoning 19.31 9.66 4 387120 9016 110193159
Creatinine renal clearance decreased 19.29 9.66 29 387095 21786 110180389
Normochromic normocytic anaemia 19.04 9.66 11 387113 13046 110189129
Injection site haemorrhage 19.03 9.66 56 387068 32972 110169203
Hallucination, auditory 18.92 9.66 40 387084 26357 110175818
Bladder cancer 18.91 9.66 26 387098 20266 110181909
Feeding intolerance 18.87 9.66 22 387102 1162 110201013
Amputation stump pain 18.86 9.66 7 387117 44 110202131
Cholecystitis 18.84 9.66 155 386969 25727 110176448
Drug reaction with eosinophilia and systemic symptoms 18.77 9.66 190 386934 81905 110120270
Klebsiella test positive 18.75 9.66 32 387092 2414 110199761
Klebsiella bacteraemia 18.74 9.66 48 387076 4821 110197354
Carbon dioxide decreased 18.63 9.66 47 387077 4677 110197498
Magnesium deficiency 18.58 9.66 18 387106 767 110201408
Infective pulmonary exacerbation of cystic fibrosis 18.33 9.66 101 387023 14670 110187505
Pharyngeal paraesthesia 18.32 9.66 43 387081 4089 110198086
Light chain analysis increased 18.31 9.66 31 387093 2324 110199851
Joint effusion 18.28 9.66 28 387096 20877 110181298
Vein discolouration 18.24 9.66 14 387110 433 110201742
Myoglobinuria 18.22 9.66 22 387102 1206 110200969
Large intestine perforation 18.22 9.66 110 387014 16519 110185656
Aspergillus infection 18.20 9.66 39 387085 25577 110176598
Lung opacity 18.20 9.66 85 387039 11567 110190608
Coronary artery occlusion 18.19 9.66 17 387107 15755 110186420
Oxygen therapy 18.17 9.66 43 387081 4110 110198065
Gastroenteritis radiation 18.14 9.66 18 387106 790 110201385
Haemoglobin decreased 18.11 9.66 1054 386070 247673 109954502
Influenza like illness 18.05 9.66 421 386703 87991 110114184
Heart rate increased 18.02 9.66 644 386480 143190 110058985
Polyarthritis 17.97 9.66 24 387100 18939 110183236
Non-cardiac chest pain 17.89 9.66 77 387047 10121 110192054
Breast cancer metastatic 17.79 9.66 82 387042 11099 110191076
Myositis 17.75 9.66 53 387071 31063 110171112
Myopathy 17.74 9.66 38 387086 24922 110177253
Hyperreflexia 17.72 9.66 73 387051 9412 110192763
Nasal mucosal disorder 17.66 9.66 27 387097 1856 110200319
Blood phosphorus decreased 17.61 9.66 63 387061 7602 110194573
Body temperature decreased 17.60 9.66 68 387056 36867 110165308
Therapy cessation 17.60 9.66 237 386887 44620 110157555
Visual acuity reduced 17.50 9.66 56 387068 32117 110170058
Overlap syndrome 17.48 9.66 5 387119 9054 110193121
Arteriosclerosis 17.36 9.66 38 387086 24729 110177446
Choking sensation 17.36 9.66 44 387080 4392 110197783
Acute myeloid leukaemia 17.35 9.66 207 386917 37903 110164272
Respiratory failure 17.35 9.66 921 386203 214411 109987764
Impaired work ability 17.33 9.66 42 387082 26377 110175798
Hypomania 17.33 9.66 7 387117 10203 110191972
Oesophagitis 17.30 9.66 165 386959 28550 110173625
Nasal congestion 17.27 9.66 241 386883 98041 110104134
Decreased immune responsiveness 17.21 9.66 73 387051 9533 110192642
Intestinal ischaemia 17.08 9.66 106 387018 16073 110186102
Nephrotic syndrome 17.05 9.66 14 387110 13817 110188358
Headache 16.99 9.66 3417 383707 878960 109323215
Confusional state 16.95 9.66 1411 385713 467269 109734906
5-hydroxyindolacetic acid in urine 16.93 9.66 5 387119 13 110202162
Coronary artery stenosis 16.87 9.66 14 387110 13744 110188431
Chronic graft versus host disease 16.86 9.66 6 387118 9451 110192724
Tubulointerstitial nephritis 16.78 9.66 116 387008 54168 110148007
Swollen tongue 16.74 9.66 133 386991 60229 110141946
Hypoalbuminaemia 16.72 9.66 165 386959 28809 110173366
Abdominal tenderness 16.70 9.66 87 387037 12370 110189805
Product administration interrupted 16.64 9.66 81 387043 11211 110190964
Herpes zoster 16.56 9.66 273 386851 108106 110094069
Haematemesis 16.55 9.66 295 386829 58813 110143362
Genitourinary tract neoplasm 16.52 9.66 7 387117 65 110202110
Injection site warmth 16.52 9.66 22 387102 17383 110184792
Premenstrual syndrome 16.46 9.66 15 387109 591 110201584
Congenital anomaly in offspring 16.43 9.66 7 387117 66 110202109
Hypergeusia 16.41 9.66 5 387119 15 110202160
Abortion spontaneous 16.41 9.66 63 387061 34219 110167956
Breast cancer stage I 16.40 9.66 3 387121 7384 110194791
Haematochezia 16.36 9.66 295 386829 115229 110086946
Femur fracture 16.36 9.66 90 387034 44379 110157796
Malignant catatonia 16.36 9.66 16 387108 690 110201485
Glioblastoma multiforme 16.34 9.66 23 387101 1467 110200708
Postural orthostatic tachycardia syndrome 16.28 9.66 26 387098 1856 110200319
Onychalgia 16.27 9.66 20 387104 1117 110201058
Toxic encephalopathy 16.26 9.66 100 387024 15114 110187061
Multiple drug therapy 16.26 9.66 4 387120 8010 110194165
Therapeutic product effect prolonged 16.13 9.66 16 387108 702 110201473
Ischaemic hepatitis 16.04 9.66 44 387080 4604 110197571
Miosis 16.02 9.66 33 387091 21950 110180225
Catheter site swelling 16.00 9.66 29 387095 2295 110199880
Medical device site fistula 16.00 9.66 6 387118 39 110202136
IIIrd nerve paresis 15.96 9.66 10 387114 221 110201954
Oral discomfort 15.86 9.66 80 387044 11231 110190944
Endoscopic retrograde cholangiopancreatography 15.84 9.66 10 387114 224 110201951
Tryptase increased 15.83 9.66 18 387106 925 110201250
Delayed recovery from anaesthesia 15.71 9.66 28 387096 2187 110199988
Perihepatic abscess 15.70 9.66 9 387115 168 110202007
Haematoma 15.69 9.66 130 386994 58346 110143829
Device difficult to use 15.68 9.66 26 387098 18779 110183396
Inappropriate schedule of product administration 15.63 9.66 569 386555 203068 109999107
Depressive symptom 15.59 9.66 5 387119 8409 110193766
Intestinal infarction 15.58 9.66 22 387102 1408 110200767
Rhinovirus infection 15.57 9.66 82 387042 11707 110190468
Plantar erythema 15.56 9.66 11 387113 299 110201876
Granulocytopenia 15.51 9.66 13 387111 12702 110189473
Inability to afford medication 15.50 9.66 40 387084 4036 110198139
Nail pigmentation 15.45 9.66 12 387112 378 110201797
Mucormycosis 15.43 9.66 9 387115 10619 110191556
Hepatitis 15.41 9.66 222 386902 89832 110112343
Psychomotor skills impaired 15.38 9.66 3 387121 7055 110195120
Oral candidiasis 15.36 9.66 231 386893 44529 110157646
Dyslipidaemia 15.34 9.66 20 387104 15945 110186230
Madarosis 15.31 9.66 36 387088 3427 110198748
Visual impairment 15.26 9.66 356 386768 134072 110068103
Weight fluctuation 15.25 9.66 131 386993 22014 110180161
Antipsychotic drug level increased 15.25 9.66 3 387121 7012 110195163
Hair texture abnormal 15.24 9.66 39 387085 3915 110198260
Metastases to meninges 15.24 9.66 46 387078 5082 110197093
Flatulence 15.22 9.66 262 386862 51887 110150288
Cardiac failure congestive 15.22 9.66 407 386717 150593 110051582
Endocrine toxicity 15.17 9.66 7 387117 81 110202094
Livedo reticularis 15.07 9.66 48 387076 5458 110196717
Toxic skin eruption 15.07 9.66 155 386969 27360 110174815
Metastases to spinal cord 15.05 9.66 10 387114 245 110201930
Gastric cancer 15.05 9.66 10 387114 10998 110191177
Blood triglycerides increased 14.95 9.66 39 387085 23887 110178288
Weight decreased 14.92 9.66 1864 385260 466193 109735982
Ear pain 14.89 9.66 117 387007 53109 110149066
Subileus 14.87 9.66 53 387071 6384 110195791
Infusion site streaking 14.86 9.66 14 387110 576 110201599
Myalgia 14.76 9.66 632 386492 221749 109980426
Infusion site pain 14.72 9.66 108 387016 17311 110184864
Nocardiosis 14.69 9.66 4 387120 7482 110194693
Alopecia areata 14.69 9.66 27 387097 2160 110200015
Uterine perforation 14.68 9.66 55 387069 6785 110195390
Hiccups 14.66 9.66 86 387038 12783 110189392
Uveitis 14.65 9.66 34 387090 21676 110180499
Vessel puncture site inflammation 14.61 9.66 4 387120 7 110202168
Transaminases increased 14.57 9.66 307 386817 63083 110139092
Feeding disorder 14.52 9.66 126 386998 21236 110180939
Acute myocardial infarction 14.52 9.66 206 386918 83571 110118604
Oedema peripheral 14.50 9.66 973 386151 327687 109874488
Catatonia 14.48 9.66 11 387113 11289 110190886
Neuritis 14.43 9.66 4 387120 7395 110194780
Abdominal mass 14.38 9.66 44 387080 4897 110197278
Chemotherapeutic drug level increased 14.34 9.66 13 387111 509 110201666
Perforation 14.30 9.66 24 387100 1786 110200389
Catarrh 14.24 9.66 4 387120 7331 110194844
Sexual dysfunction 14.23 9.66 6 387118 8524 110193651
Bone marrow myelogram abnormal 14.19 9.66 7 387117 95 110202080
Aspartate aminotransferase decreased 14.14 9.66 21 387103 1407 110200768
Aortic stenosis 14.06 9.66 86 387038 12973 110189202
Chest pain 14.02 9.66 1514 385610 374861 109827314
Congenital hiatus hernia 14 9.66 51 387073 6208 110195967
Staphylococcus test positive 13.99 9.66 57 387067 7313 110194862
Intrinsic factor deficiency 13.98 9.66 3 387121 0 110202175
Hypertonia neonatal 13.98 9.66 3 387121 0 110202175
Prepuce redundant 13.98 9.66 3 387121 0 110202175
Foetal damage 13.98 9.66 3 387121 0 110202175
Gastroenteritis viral 13.95 9.66 169 386955 31057 110171118
Metastases to liver 13.90 9.66 187 386937 35199 110166976
Vision blurred 13.86 9.66 568 386556 128454 110073721
Food intolerance 13.82 9.66 41 387083 4486 110197689
Cytomegalovirus infection reactivation 13.80 9.66 27 387097 18306 110183869
Hyperemesis gravidarum 13.79 9.66 13 387111 535 110201640
Oesophageal carcinoma 13.79 9.66 12 387112 11512 110190663
Epstein-Barr virus infection 13.76 9.66 28 387096 18710 110183465
Catheter site infection 13.73 9.66 60 387064 7940 110194235
Bone disorder 13.66 9.66 34 387090 21158 110181017
Abdominal infection 13.65 9.66 42 387082 4689 110197486
Generalised tonic-clonic seizure 13.62 9.66 268 386856 54412 110147763
Pancreatic neuroendocrine tumour metastatic 13.57 9.66 9 387115 220 110201955
Enterocutaneous fistula 13.53 9.66 27 387097 2296 110199879
Pelvic neoplasm 13.50 9.66 10 387114 293 110201882
Formication 13.47 9.66 47 387077 5601 110196574
Metastases to abdominal cavity 13.47 9.66 16 387108 862 110201313
Cerebral microhaemorrhage 13.47 9.66 12 387112 459 110201716
Asphyxia 13.46 9.66 18 387106 14197 110187978
Exposure to allergen 13.46 9.66 13 387111 552 110201623
Nail infection 13.41 9.66 28 387096 2460 110199715
Haemorrhoidal haemorrhage 13.36 9.66 60 387064 8033 110194142
Cardiac failure 13.35 9.66 529 386595 187097 110015078
Electrocardiogram PR shortened 13.32 9.66 11 387113 379 110201796
Electrocardiogram T wave inversion 13.32 9.66 47 387077 5633 110196542
Foetal heart rate abnormal 13.27 9.66 14 387110 661 110201514
Petit mal epilepsy 13.25 9.66 57 387067 7490 110194685
Biliary dilatation 13.20 9.66 35 387089 3590 110198585
Ulcer haemorrhage 13.20 9.66 38 387086 22533 110179642
Iritis 13.14 9.66 41 387083 4611 110197564
5-hydroxyindolacetic acid 13.13 9.66 4 387120 12 110202163
Erythropenia 13.12 9.66 12 387112 475 110201700
Polymenorrhoea 13.06 9.66 18 387106 1126 110201049
Biliary obstruction 13.04 9.66 46 387078 5512 110196663
Periorbital disorder 13.04 9.66 6 387118 69 110202106
Apathy 13.04 9.66 23 387101 16216 110185959
Skin fissures 13.02 9.66 137 386987 24321 110177854
Vocal cord paralysis 13.02 9.66 31 387093 2975 110199200
Electrocardiogram ST segment elevation 13.00 9.66 65 387059 9095 110193080
Muscle rigidity 12.98 9.66 135 386989 23896 110178279
Influenza 12.97 9.66 720 386404 168381 110033794
Spinal fusion surgery 12.95 9.66 8 387116 9148 110193027
Head and neck cancer metastatic 12.89 9.66 4 387120 13 110202162
Tumour marker increased 12.85 9.66 43 387081 5017 110197158
Cerebral haematoma 12.83 9.66 9 387115 9623 110192552
Metastases to peritoneum 12.79 9.66 46 387078 5564 110196611
Nasal oedema 12.78 9.66 4 387120 6835 110195340
Adult failure to thrive 12.77 9.66 10 387114 319 110201856
Tongue oedema 12.73 9.66 60 387064 8196 110193979
Subchorionic haemorrhage 12.72 9.66 8 387116 178 110201997
Human chorionic gonadotropin decreased 12.67 9.66 6 387118 74 110202101
Venous oxygen saturation increased 12.67 9.66 5 387119 38 110202137
Pancreatic enzymes abnormal 12.67 9.66 4 387120 14 110202161
Pulmonary sepsis 12.66 9.66 44 387080 5234 110196941
Blood bilirubin abnormal 12.63 9.66 23 387101 1827 110200348
Serum amyloid A protein increased 12.57 9.66 16 387108 926 110201249
Sensitivity to weather change 12.55 9.66 10 387114 10018 110192157
Anorectal disorder 12.54 9.66 29 387095 2730 110199445
Progressive multifocal leukoencephalopathy 12.51 9.66 45 387079 24911 110177264
Blood creatine increased 12.49 9.66 76 387048 11445 110190730
Radiculopathy 12.48 9.66 31 387093 19305 110182870
Lip pruritus 12.46 9.66 19 387105 1303 110200872
Transposition of the great vessels 12.46 9.66 6 387118 77 110202098
Electrolyte depletion 12.45 9.66 12 387112 508 110201667
General physical health deterioration 12.42 9.66 1301 385823 423994 109778181
Musculoskeletal chest pain 12.40 9.66 155 386969 28692 110173483
Alpha haemolytic streptococcal infection 12.39 9.66 34 387090 3559 110198616
Face oedema 12.38 9.66 175 386949 33294 110168881
Catheter site pain 12.35 9.66 50 387074 6396 110195779
Wrong patient received product 12.30 9.66 4 387120 6670 110195505
Stomatitis 12.26 9.66 798 386326 269444 109932731
Platelet count abnormal 12.25 9.66 49 387075 6233 110195942
Economic problem 12.22 9.66 37 387087 4094 110198081
Intraocular pressure increased 12.22 9.66 12 387112 10864 110191311
Cardiac operation 12.15 9.66 3 387121 5992 110196183
General symptom 12.14 9.66 8 387116 8838 110193337
Gastrointestinal haemorrhage 12.14 9.66 465 386659 165053 110037122
Subarachnoid haemorrhage 12.12 9.66 58 387066 29644 110172531
Sleep terror 12.12 9.66 4 387120 6606 110195569
Medulloblastoma recurrent 12.12 9.66 8 387116 194 110201981
Lipase increased 12.11 9.66 109 387015 18563 110183612
Muscle twitching 12.09 9.66 159 386965 29776 110172399
Red cell distribution width increased 12.06 9.66 104 387020 17498 110184677
Cardiac pacemaker evaluation 12.01 9.66 7 387117 135 110202040
Drug tolerance 12.00 9.66 25 387099 16560 110185615
Campylobacter gastroenteritis 11.94 9.66 23 387101 1906 110200269
Therapeutic response shortened 11.94 9.66 58 387066 29525 110172650
Total lung capacity decreased 11.94 9.66 53 387071 7061 110195114
Intensive care 11.93 9.66 26 387098 2353 110199822
Cytomegalovirus chorioretinitis 11.92 9.66 5 387119 7123 110195052
Urine output decreased 11.87 9.66 114 387010 19762 110182413
Gastrointestinal anastomotic leak 11.81 9.66 14 387110 753 110201422
Left ventricular dysfunction 11.77 9.66 130 386994 23363 110178812
Haemodialysis 11.76 9.66 28 387096 17691 110184484
Proctitis bacterial 11.74 9.66 7 387117 141 110202034
Depressed level of consciousness 11.74 9.66 301 386823 111977 110090198
Sleep apnoea syndrome 11.74 9.66 88 387036 40359 110161816
Ventricular hypertrophy 11.68 9.66 5 387119 7040 110195135
Bone marrow failure 11.67 9.66 275 386849 57573 110144602
Cerebellar stroke 11.66 9.66 15 387109 877 110201298
Deformity 11.66 9.66 11 387113 10149 110192026
Palpitations 11.65 9.66 675 386449 158537 110043638
Polymyalgia rheumatica 11.63 9.66 4 387120 6438 110195737
Uterine hypotonus 11.61 9.66 7 387117 144 110202031
Binocular eye movement disorder 11.61 9.66 7 387117 144 110202031
Faeces hard 11.61 9.66 37 387087 4209 110197966
Cardiac failure chronic 11.60 9.66 19 387105 13792 110188383
Hypertransaminasaemia 11.60 9.66 133 386991 24122 110178053
Papillary cystadenoma lymphomatosum 11.56 9.66 8 387116 210 110201965
Pallor 11.56 9.66 269 386855 56198 110145977
Medical device pain 11.55 9.66 19 387105 1391 110200784
Seminoma 11.55 9.66 9 387115 285 110201890
Starvation 11.53 9.66 16 387108 1007 110201168
Alveolitis 11.52 9.66 38 387086 4401 110197774
Gout 11.52 9.66 186 386938 36380 110165795
Painful respiration 11.50 9.66 34 387090 3713 110198462
Coating in mouth 11.49 9.66 9 387115 287 110201888
Lethargy 11.48 9.66 418 386706 93158 110109017
Arterial angioplasty 11.48 9.66 5 387119 50 110202125
Superinfection 11.46 9.66 3 387121 5760 110196415
COVID-19 immunisation 11.45 9.66 18 387106 1268 110200907
Picornavirus infection 11.44 9.66 7 387117 148 110202027
Pelvic fracture 11.40 9.66 20 387104 14134 110188041
Stress 11.37 9.66 464 386660 104884 110097291
Conjunctivitis allergic 11.37 9.66 5 387119 6926 110195249
Hepatitis B reactivation 11.36 9.66 6 387118 7478 110194697
Sinus node dysfunction 11.35 9.66 9 387115 9038 110193137
Disturbance in attention 11.26 9.66 151 386973 61844 110140331
Complications of transplanted kidney 11.24 9.66 6 387118 7436 110194739
Pharyngeal hypoaesthesia 11.23 9.66 11 387113 475 110201700
Irritability 11.20 9.66 110 387014 47699 110154476
Carpal tunnel syndrome 11.18 9.66 41 387083 22569 110179606
Vaginal cellulitis 11.18 9.66 6 387118 98 110202077
Post embolisation syndrome 11.18 9.66 6 387118 98 110202077
Deafness permanent 11.16 9.66 15 387109 916 110201259
Atrial flutter 11.14 9.66 132 386992 24130 110178045
Pancreatic carcinoma metastatic 11.13 9.66 36 387088 4128 110198047
Drug level increased 11.09 9.66 110 387014 47609 110154566
Tuberculosis 11.08 9.66 29 387095 17745 110184430
Multiple fractures 11.08 9.66 9 387115 8931 110193244
Large intestine anastomosis 11.07 9.66 6 387118 100 110202075
Demyelination 11.07 9.66 10 387114 9419 110192756
Eye haemorrhage 11.06 9.66 15 387109 11759 110190416
Gastritis 11.05 9.66 256 386868 53443 110148732
Proctitis 11.03 9.66 27 387097 16900 110185275
Pulmonary toxicity 11.03 9.66 29 387095 17717 110184458
Vena cava thrombosis 11.01 9.66 32 387092 3462 110198713
Haemarthrosis 10.94 9.66 6 387118 7323 110194852
Brain abscess 10.93 9.66 5 387119 6769 110195406
Pityriasis rosea 10.90 9.66 8 387116 231 110201944
Wheelchair user 10.89 9.66 7 387117 7835 110194340
Insurance issue 10.87 9.66 69 387055 10543 110191632
Gallbladder enlargement 10.87 9.66 23 387101 2039 110200136
Pleuritic pain 10.87 9.66 95 387029 16045 110186130
Product prescribing error 10.85 9.66 121 387003 51210 110150965
Spinal cord injury thoracic 10.81 9.66 7 387117 164 110202011
Transplant dysfunction 10.81 9.66 8 387116 8320 110193855
Rotator cuff syndrome 10.78 9.66 27 387097 16767 110185408
Decerebrate posture 10.78 9.66 8 387116 235 110201940
Agonal respiration 10.78 9.66 9 387115 315 110201860
Procedural dizziness 10.76 9.66 6 387118 106 110202069
Blood pressure abnormal 10.74 9.66 123 387001 22301 110179874
Onychoclasis 10.73 9.66 52 387072 7185 110194990
Vascular complication associated with device 10.70 9.66 3 387121 6 110202169
Platelet count increased 10.69 9.66 140 386984 26194 110175981
Antithrombin III decreased 10.61 9.66 11 387113 509 110201666
Gastrointestinal motility disorder 10.59 9.66 52 387072 7224 110194951
Emotional distress 10.57 9.66 218 386906 44629 110157546
Influenza B virus test positive 10.56 9.66 10 387114 414 110201761
Enterococcus test positive 10.54 9.66 28 387096 2876 110199299
Extensor plantar response 10.53 9.66 22 387102 1933 110200242
Vertebral column mass 10.49 9.66 9 387115 327 110201848
Stoma site pain 10.47 9.66 22 387102 1941 110200234
Bacteroides infection 10.44 9.66 28 387096 2891 110199284
Human herpesvirus 6 infection 10.40 9.66 5 387119 6576 110195599
Blood pressure inadequately controlled 10.34 9.66 7 387117 7626 110194549
Palmoplantar keratoderma 10.34 9.66 3 387121 5384 110196791
Infusion related reaction 10.33 9.66 1172 385952 379990 109822185
Dermatitis acneiform 10.32 9.66 78 387046 12617 110189558
Hepatic pain 10.31 9.66 38 387086 4652 110197523
Streptococcus test positive 10.30 9.66 26 387098 2588 110199587
Small cell lung cancer extensive stage 10.29 9.66 4 387120 29 110202146
Ovarian hyperstimulation syndrome 10.26 9.66 3 387121 5357 110196818
Flank pain 10.25 9.66 125 386999 23005 110179170
Stomatitis haemorrhagic 10.25 9.66 8 387116 254 110201921
Mycotic allergy 10.24 9.66 4 387120 5950 110196225
Gastrointestinal sounds abnormal 10.22 9.66 45 387079 5973 110196202
Tardive dyskinesia 10.22 9.66 20 387104 13559 110188616
Enterovirus test positive 10.22 9.66 9 387115 339 110201836
Restless arm syndrome 10.19 9.66 5 387119 67 110202108
Hypobarism 10.18 9.66 4 387120 30 110202145
Cardiac ventricular disorder 10.15 9.66 9 387115 342 110201833
Appendicitis perforated 10.15 9.66 32 387092 3620 110198555
Rhinorrhoea 10.13 9.66 448 386676 102218 110099957
BK virus infection 10.13 9.66 19 387105 13087 110189088
Body temperature increased 10.10 9.66 257 386867 54456 110147719
Pelvic abscess 10.10 9.66 26 387098 2620 110199555
Blood lactic acid increased 10.08 9.66 92 387032 15729 110186446
Cytotoxic oedema 10.08 9.66 10 387114 439 110201736
Duodenal ulcer haemorrhage 10.07 9.66 8 387116 8029 110194146
Laryngeal dyspnoea 10.04 9.66 9 387115 347 110201828
Feeling cold 10.01 9.66 171 386953 33816 110168359
Dysphemia 9.98 9.66 34 387090 4003 110198172
Corneal bleeding 9.96 9.66 4 387120 32 110202143
Blood sodium decreased 9.95 9.66 189 386935 38130 110164045
Pneumonia cytomegaloviral 9.94 9.66 6 387118 6948 110195227
Sialoadenitis 9.93 9.66 26 387098 2647 110199528
Atypical pneumonia 9.92 9.66 54 387070 7808 110194367
Lichen sclerosus 9.92 9.66 16 387108 1152 110201023
Neck pain 9.91 9.66 342 386782 122788 110079387
Alanine aminotransferase decreased 9.89 9.66 21 387103 1867 110200308
Rhinitis allergic 9.88 9.66 31 387093 17891 110184284
Metastases to lymph nodes 9.88 9.66 88 387036 14944 110187231
Acute coronary syndrome 9.86 9.66 124 387000 22988 110179187
Eye disorder 9.83 9.66 60 387064 28846 110173329
Chronic hepatitis B 9.82 9.66 11 387113 556 110201619
Varicella zoster virus infection 9.82 9.66 5 387119 6363 110195812
Alopecia totalis 9.82 9.66 10 387114 453 110201722
Incarcerated umbilical hernia 9.81 9.66 5 387119 73 110202102
Exercise tolerance decreased 9.77 9.66 17 387107 12050 110190125
Asthma-chronic obstructive pulmonary disease overlap syndrome 9.75 9.66 5 387119 6339 110195836
Central nervous system stimulation 9.75 9.66 5 387119 74 110202101
Metabolic acidosis 9.75 9.66 270 386854 99474 110102701
Change of bowel habit 9.75 9.66 27 387097 2842 110199333
Vulvovaginal mycotic infection 9.74 9.66 41 387083 5336 110196839
Ejection fraction decreased 9.73 9.66 199 386925 40681 110161494
Pulmonary alveolar haemorrhage 9.67 9.66 37 387087 20113 110182062

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human herpesvirus 6 infection 46.21 35.29 15 482 45 113411
Penile oedema 43.62 35.29 14 483 40 113416
Cardiac failure 42.73 35.29 15 482 61 113395
Congestive cardiomyopathy 39.86 35.29 14 483 57 113399

Pharmacologic Action:

SourceCodeDescription
ATC A04AA01 ALIMENTARY TRACT AND METABOLISM
ANTIEMETICS AND ANTINAUSEANTS
ANTIEMETICS AND ANTINAUSEANTS
Serotonin (5HT3) antagonists
MeSH PA D000932 Antiemetics
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D058831 Serotonin 5-HT3 Receptor Antagonists
FDA MoA N0000175817 Serotonin 3 Receptor Antagonists
FDA EPC N0000175818 Serotonin-3 Receptor Antagonist
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:55323 antidiarrhoeal drug
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:33282 antibacterial agent

Related Drugs by ATC class:

A04AA Serotonin (5HT3) antagonists 4 drugs
dolasetrongranisetronpalonosetrontropisetron

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chemotherapy-induced nausea and vomiting indication 236084000
Prevention of Radiation-Induced Nausea and Vomiting indication
Prevention of Post-Operative Nausea and Vomiting indication
Excessive vomiting in pregnancy off-label use 14094001
Torsades de pointes contraindication 31722008
Hepatic failure contraindication 59927004
Extrapyramidal disease contraindication 76349003
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.13 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
5-hydroxytryptamine receptor 3A Ion channel ANTAGONIST Ki 7.80 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 6.34 DRUG MATRIX
Aldehyde oxidase Enzyme IC50 5.68 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 4.69 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.77 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 7.52 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 6.80 CHEMBL
Solute carrier family 22 member 3 Transporter IC50 4.76 CHEMBL
Neuronal acetylcholine receptor; alpha4/beta2 Ion channel Ki 4.34 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.09 WOMBAT-PK
5-hydroxytryptamine receptor 3B Ion channel Ki 8.30 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 5.43 CHEMBL
Mu-type opioid receptor GPCR Ki 5.54 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5 CHEMBL
Gastrin/cholecystokinin type B receptor GPCR Ki 6.17 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.17 CHEMBL
Neuronal acetylcholine receptor subunit alpha-7 Ion channel IC50 4.60 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 5.30 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 5.92 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel Ki 9.11 CHEMBL
5-hydroxytryptamine receptor 1D GPCR Ki 4.70 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel Kd 7.11 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Ki 9.11 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 5 CHEMBL
Serotonin 3 receptor (5HT3) Ion channel Ki 7.92 CHEMBL

External reference:

IDSource
4019865 VUID
N0000147951 NUI
D00456 KEGG_DRUG
103639-04-9 SECONDARY_CAS_RN
4019563 VANDF
4019865 VANDF
C0061851 UMLSCUI
CHEBI:7773 CHEBI
S87 PDB_CHEM_ID
CHEMBL46 ChEMBL_ID
CHEMBL3186492 ChEMBL_ID
DB00904 DRUGBANK_ID
D017294 MESH_DESCRIPTOR_UI
4595 PUBCHEM_CID
2290 IUPHAR_LIGAND_ID
5965 INN_ID
4AF302ESOS UNII
203148 RXNORM
27290 MMSL
39615 MMSL
5202 MMSL
90631 MMSL
d00867 MMSL
003568 NDDF
004807 NDDF
108418007 SNOMEDCT_US
108419004 SNOMEDCT_US
372487007 SNOMEDCT_US
830157000 SNOMEDCT_US
4AF302ESOS INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ondansetron Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0064 SOLUTION 4 mg ORAL ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0121-0882 SOLUTION 4 mg ORAL ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0121-4882 SOLUTION 4 mg ORAL ANDA 26 sections
Ondansetron Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0143-9771 INJECTION, SOLUTION 32 mg INTRAVENOUS ANDA 24 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-9890 INJECTION 2 mg INTRAMUSCULAR ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0143-9891 INJECTION 2 mg INTRAMUSCULAR ANDA 26 sections
ONDANSETRON HUMAN PRESCRIPTION DRUG LABEL 1 0404-9930 INJECTION 2 mg INTRAVENOUS ANDA 19 sections
ONDANSETRON HUMAN PRESCRIPTION DRUG LABEL 1 0404-9930 INJECTION 2 mg INTRAVENOUS ANDA 19 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-0009 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 31 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-2271 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 31 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-4755 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 31 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0409-4759 INJECTION, SOLUTION 2 mg INTRAMUSCULAR ANDA 31 sections
ondansetron hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8185 TABLET, FILM COATED 4 mg ORAL ANDA 27 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6078 INJECTION 2 mg INTRAMUSCULAR ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6079 INJECTION 2 mg INTRAMUSCULAR ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6080 INJECTION 2 mg INTRAMUSCULAR ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0641-6286 INJECTION 2 mg INTRAMUSCULAR ANDA 26 sections
ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0904-6551 TABLET, FILM COATED 4 mg ORAL ANDA 26 sections
ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 0904-6552 TABLET, FILM COATED 8 mg ORAL ANDA 26 sections
Ondansetron Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-575 TABLET, FILM COATED 8 mg ORAL ANDA 22 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 11819-365 TABLET, ORALLY DISINTEGRATING 8 mg ORAL ANDA 26 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 11819-371 TABLET, ORALLY DISINTEGRATING 8 mg ORAL ANDA 27 sections
Ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 16590-545 TABLET, ORALLY DISINTEGRATING 4 mg ORAL ANDA 12 sections
Ondansetron Human Prescription Drug Label 1 16714-159 TABLET, FILM COATED 4 mg ORAL ANDA 26 sections
Ondansetron Human Prescription Drug Label 1 16714-160 TABLET, FILM COATED 8 mg ORAL ANDA 26 sections
Ondansetron Human Prescription Drug Label 1 16714-200 TABLET, ORALLY DISINTEGRATING 4 mg ORAL ANDA 26 sections
Ondansetron Human Prescription Drug Label 1 16714-201 TABLET, ORALLY DISINTEGRATING 8 mg ORAL ANDA 26 sections
Ondansetron Human Prescription Drug Label 1 16714-671 SOLUTION 4 mg ORAL ANDA 26 sections
ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 16729-298 INJECTION 2 mg INTRAVENOUS ANDA 27 sections
ondansetron HUMAN PRESCRIPTION DRUG LABEL 1 16729-298 INJECTION 2 mg INTRAVENOUS ANDA 27 sections