Stem definition | Drug id | CAS RN |
---|---|---|
serotonin receptor antagonists (5-HT3) | 1992 | 99614-02-5 |
Dose | Unit | Route |
---|---|---|
16 | mg | O |
16 | mg | P |
16 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 5.70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.17 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 62 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.27 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 4, 1991 | FDA | NOVARTIS PHARMS CORP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 891.08 | 9.89 | 1091 | 191388 | 818242 | 49594403 |
Febrile neutropenia | 776.35 | 9.89 | 1358 | 191121 | 96309 | 50316336 |
Nausea | 560.08 | 9.89 | 4577 | 187902 | 700821 | 49711824 |
Vomiting | 520.01 | 9.89 | 3257 | 189222 | 457501 | 49955144 |
Contraindicated product administered | 432.08 | 9.89 | 36 | 192443 | 148922 | 50263723 |
Synovitis | 431.08 | 9.89 | 8 | 192471 | 123857 | 50288788 |
Joint swelling | 402.27 | 9.89 | 216 | 192263 | 245070 | 50167575 |
Constipation | 395.51 | 9.89 | 1574 | 190905 | 184134 | 50228511 |
Systemic lupus erythematosus | 369.36 | 9.89 | 49 | 192430 | 140573 | 50272072 |
Rheumatoid arthritis | 364.65 | 9.89 | 157 | 192322 | 202393 | 50210252 |
Diarrhoea | 349.64 | 9.89 | 3591 | 188888 | 584885 | 49827760 |
Hand deformity | 346.50 | 9.89 | 7 | 192472 | 100192 | 50312453 |
Arthropathy | 331.08 | 9.89 | 95 | 192384 | 157811 | 50254834 |
Therapeutic product effect decreased | 318.16 | 9.89 | 65 | 192414 | 135985 | 50276660 |
Drug intolerance | 316.04 | 9.89 | 224 | 192255 | 218880 | 50193765 |
Treatment failure | 301.36 | 9.89 | 76 | 192403 | 137561 | 50275084 |
Glossodynia | 258.47 | 9.89 | 61 | 192418 | 115508 | 50297137 |
Dehydration | 243.48 | 9.89 | 1186 | 191293 | 151263 | 50261382 |
Neutropenia | 236.93 | 9.89 | 1152 | 191327 | 146813 | 50265832 |
Abdominal pain | 227.70 | 9.89 | 1608 | 190871 | 234620 | 50178025 |
Disease progression | 227.05 | 9.89 | 841 | 191638 | 95025 | 50317620 |
Wound | 221.02 | 9.89 | 64 | 192415 | 105730 | 50306915 |
Pericarditis | 220.07 | 9.89 | 22 | 192457 | 78667 | 50333978 |
Arthralgia | 213.31 | 9.89 | 902 | 191577 | 437800 | 49974845 |
Swelling | 193.68 | 9.89 | 290 | 192189 | 200582 | 50212063 |
Torsade de pointes | 188.62 | 9.89 | 229 | 192250 | 11606 | 50401039 |
Neuropathy peripheral | 181.20 | 9.89 | 789 | 191690 | 95968 | 50316677 |
Emotional distress | 169.75 | 9.89 | 352 | 192127 | 28311 | 50384334 |
Death | 167.34 | 9.89 | 1932 | 190547 | 323447 | 50089198 |
White blood cell count decreased | 166.54 | 9.89 | 880 | 191599 | 115842 | 50296803 |
Thrombocytopenia | 165.01 | 9.89 | 937 | 191542 | 126736 | 50285909 |
Decreased appetite | 160.99 | 9.89 | 1310 | 191169 | 199613 | 50213032 |
Drug abuse | 154.33 | 9.89 | 22 | 192457 | 59824 | 50352821 |
Mucosal inflammation | 153.83 | 9.89 | 416 | 192063 | 39726 | 50372919 |
Hepatic enzyme increased | 151.01 | 9.89 | 180 | 192299 | 137200 | 50275445 |
Duodenal ulcer perforation | 150.82 | 9.89 | 5 | 192474 | 45606 | 50367039 |
Toxicity to various agents | 150.43 | 9.89 | 369 | 192110 | 212130 | 50200515 |
Plasma cell myeloma | 149.71 | 9.89 | 353 | 192126 | 30969 | 50381676 |
Impaired healing | 146.13 | 9.89 | 42 | 192437 | 69744 | 50342901 |
Musculoskeletal stiffness | 144.80 | 9.89 | 165 | 192314 | 128316 | 50284329 |
Hypoxia | 143.00 | 9.89 | 474 | 192005 | 50649 | 50361996 |
Serotonin syndrome | 139.95 | 9.89 | 298 | 192181 | 24415 | 50388230 |
Helicobacter infection | 138.68 | 9.89 | 14 | 192465 | 49688 | 50362957 |
Electrocardiogram QT prolonged | 135.39 | 9.89 | 470 | 192009 | 51416 | 50361229 |
Drug hypersensitivity | 133.16 | 9.89 | 498 | 191981 | 250512 | 50162133 |
Febrile bone marrow aplasia | 127.40 | 9.89 | 138 | 192341 | 6173 | 50406472 |
Muscle injury | 126.65 | 9.89 | 3 | 192476 | 37108 | 50375537 |
Encephalopathy | 124.82 | 9.89 | 345 | 192134 | 33366 | 50379279 |
Discomfort | 119.08 | 9.89 | 142 | 192337 | 108238 | 50304407 |
Left-to-right cardiac shunt | 117.52 | 9.89 | 36 | 192443 | 99 | 50412546 |
Completed suicide | 111.64 | 9.89 | 207 | 192272 | 131682 | 50280963 |
Erythema | 110.43 | 9.89 | 942 | 191537 | 145472 | 50267173 |
Neutropenic sepsis | 108.65 | 9.89 | 194 | 192285 | 13953 | 50398692 |
Mobility decreased | 108.34 | 9.89 | 87 | 192392 | 79861 | 50332784 |
Abdominal discomfort | 105.15 | 9.89 | 488 | 191991 | 231153 | 50181492 |
Heart disease congenital | 103.09 | 9.89 | 62 | 192417 | 1164 | 50411481 |
Therapeutic product effect incomplete | 102.57 | 9.89 | 118 | 192361 | 91397 | 50321248 |
Pyrexia | 102.09 | 9.89 | 2020 | 190459 | 378183 | 50034462 |
Sleep disorder due to general medical condition, insomnia type | 102.05 | 9.89 | 4 | 192475 | 31443 | 50381202 |
Fatigue | 101.63 | 9.89 | 3458 | 189021 | 704143 | 49708502 |
Small intestinal obstruction | 95.91 | 9.89 | 198 | 192281 | 15870 | 50396775 |
Cytokine release syndrome | 95.87 | 9.89 | 140 | 192339 | 8494 | 50404151 |
Injection site pain | 95.06 | 9.89 | 173 | 192306 | 110851 | 50301794 |
Colitis | 94.48 | 9.89 | 342 | 192137 | 38187 | 50374458 |
Ventricular tachycardia | 93.32 | 9.89 | 194 | 192285 | 15627 | 50397018 |
Flushing | 92.61 | 9.89 | 501 | 191978 | 66514 | 50346131 |
Neutrophil count decreased | 91.24 | 9.89 | 382 | 192097 | 45644 | 50367001 |
Folliculitis | 91.08 | 9.89 | 19 | 192460 | 39206 | 50373439 |
Condition aggravated | 90.01 | 9.89 | 711 | 191768 | 296347 | 50116298 |
Intentional overdose | 89.83 | 9.89 | 64 | 192415 | 62440 | 50350205 |
Injury | 87.00 | 9.89 | 393 | 192086 | 48532 | 50364113 |
Blood cholesterol increased | 84.10 | 9.89 | 53 | 192426 | 55162 | 50357483 |
Full blood count decreased | 83.02 | 9.89 | 229 | 192250 | 22117 | 50390528 |
Hereditary angioedema | 83.00 | 9.89 | 103 | 192376 | 5339 | 50407306 |
Weight increased | 80.94 | 9.89 | 444 | 192035 | 201447 | 50211198 |
Knee arthroplasty | 77.99 | 9.89 | 20 | 192459 | 35826 | 50376819 |
Sepsis | 76.65 | 9.89 | 808 | 191671 | 132117 | 50280528 |
Overdose | 76.26 | 9.89 | 166 | 192313 | 99561 | 50313084 |
C-reactive protein abnormal | 74.62 | 9.89 | 9 | 192470 | 27800 | 50384845 |
Hospice care | 72.08 | 9.89 | 99 | 192380 | 5673 | 50406972 |
Intentional self-injury | 71.57 | 9.89 | 4 | 192475 | 23108 | 50389537 |
Injection site erythema | 71.33 | 9.89 | 109 | 192370 | 74827 | 50337818 |
Lower respiratory tract infection | 70.71 | 9.89 | 161 | 192318 | 95040 | 50317605 |
Platelet count decreased | 70.67 | 9.89 | 638 | 191841 | 100088 | 50312557 |
Laryngospasm | 69.19 | 9.89 | 67 | 192412 | 2621 | 50410024 |
Long QT syndrome | 69.05 | 9.89 | 70 | 192409 | 2897 | 50409748 |
Red blood cell sedimentation rate increased | 68.81 | 9.89 | 14 | 192465 | 29402 | 50383243 |
Oculogyric crisis | 68.37 | 9.89 | 51 | 192428 | 1386 | 50411259 |
Irritable bowel syndrome | 67.18 | 9.89 | 58 | 192421 | 51383 | 50361262 |
Anaemia | 66.50 | 9.89 | 1338 | 191141 | 251118 | 50161527 |
Type 2 diabetes mellitus | 66.09 | 9.89 | 24 | 192455 | 34351 | 50378294 |
Injection site swelling | 65.14 | 9.89 | 39 | 192440 | 41734 | 50370911 |
Myocardial infarction | 64.96 | 9.89 | 152 | 192327 | 88875 | 50323770 |
Abortion spontaneous | 63.75 | 9.89 | 40 | 192439 | 41732 | 50370913 |
Malignant neoplasm progression | 62.67 | 9.89 | 459 | 192020 | 67665 | 50344980 |
Hip arthroplasty | 62.43 | 9.89 | 19 | 192460 | 30410 | 50382235 |
Osteoarthritis | 62.26 | 9.89 | 103 | 192376 | 68503 | 50344142 |
Therapeutic response decreased | 61.99 | 9.89 | 53 | 192426 | 47178 | 50365467 |
Anhedonia | 61.18 | 9.89 | 121 | 192358 | 9403 | 50403242 |
Loss of personal independence in daily activities | 60.98 | 9.89 | 108 | 192371 | 69942 | 50342703 |
Device expulsion | 59.13 | 9.89 | 18 | 192461 | 28804 | 50383841 |
Carbohydrate antigen 125 increased | 58.87 | 9.89 | 59 | 192420 | 2408 | 50410237 |
Dystonia | 58.71 | 9.89 | 136 | 192343 | 11790 | 50400855 |
Chills | 58.69 | 9.89 | 594 | 191885 | 96093 | 50316552 |
Neoplasm progression | 58.56 | 9.89 | 243 | 192236 | 28914 | 50383731 |
Aplastic anaemia | 58.34 | 9.89 | 105 | 192374 | 7598 | 50405047 |
Asthenia | 58.25 | 9.89 | 1607 | 190872 | 317435 | 50095210 |
Tachycardia | 58.23 | 9.89 | 608 | 191871 | 99155 | 50313490 |
Inflammation | 57.89 | 9.89 | 79 | 192400 | 56833 | 50355812 |
Pancytopenia | 57.79 | 9.89 | 530 | 191949 | 83500 | 50329145 |
Congenital anomaly | 57.25 | 9.89 | 47 | 192432 | 1474 | 50411171 |
Injection site reaction | 56.60 | 9.89 | 64 | 192415 | 49968 | 50362677 |
Intestinal obstruction | 55.46 | 9.89 | 223 | 192256 | 26160 | 50386485 |
Alopecia | 53.98 | 9.89 | 634 | 191845 | 244413 | 50168232 |
Osteoporosis | 53.44 | 9.89 | 55 | 192424 | 44824 | 50367821 |
Suicide attempt | 53.43 | 9.89 | 71 | 192408 | 51661 | 50360984 |
Dysgeusia | 53.11 | 9.89 | 290 | 192189 | 38626 | 50374019 |
Ventricular fibrillation | 51.53 | 9.89 | 120 | 192359 | 10439 | 50402206 |
Retching | 50.97 | 9.89 | 135 | 192344 | 12727 | 50399918 |
Palmar-plantar erythrodysaesthesia syndrome | 50.62 | 9.89 | 180 | 192299 | 19918 | 50392727 |
Nasopharyngitis | 50.23 | 9.89 | 480 | 191999 | 192447 | 50220198 |
Pleural effusion | 50.19 | 9.89 | 502 | 191977 | 80952 | 50331693 |
Atelectasis | 49.82 | 9.89 | 168 | 192311 | 18102 | 50394543 |
Clostridium difficile infection | 49.52 | 9.89 | 210 | 192269 | 25229 | 50387416 |
Anxiety | 49.30 | 9.89 | 949 | 191530 | 176657 | 50235988 |
Fall | 48.79 | 9.89 | 939 | 191540 | 333993 | 50078652 |
Desmoplastic small round cell tumour | 48.77 | 9.89 | 15 | 192464 | 42 | 50412603 |
Opisthotonus | 48.14 | 9.89 | 24 | 192455 | 305 | 50412340 |
Hypomagnesaemia | 48.09 | 9.89 | 195 | 192284 | 22961 | 50389684 |
Arthritis | 47.23 | 9.89 | 170 | 192309 | 86551 | 50326094 |
Hair colour changes | 47.18 | 9.89 | 55 | 192424 | 2669 | 50409976 |
Hypokalaemia | 47.05 | 9.89 | 527 | 191952 | 87465 | 50325180 |
Femur fracture | 46.82 | 9.89 | 44 | 192435 | 37420 | 50375225 |
Clonus | 45.34 | 9.89 | 67 | 192412 | 4108 | 50408537 |
Psoriatic arthropathy | 45.15 | 9.89 | 68 | 192411 | 46964 | 50365681 |
Dilatation intrahepatic duct acquired | 45.08 | 9.89 | 29 | 192450 | 616 | 50412029 |
Pain | 45.05 | 9.89 | 1774 | 190705 | 577129 | 49835516 |
Ascites | 43.52 | 9.89 | 259 | 192220 | 35602 | 50377043 |
Calcium ionised decreased | 43.48 | 9.89 | 21 | 192458 | 248 | 50412397 |
Osteonecrosis of jaw | 43.29 | 9.89 | 36 | 192443 | 32490 | 50380155 |
Accidental exposure to product | 42.82 | 9.89 | 17 | 192462 | 23040 | 50389605 |
Hypotension | 42.34 | 9.89 | 1184 | 191295 | 234285 | 50178360 |
Dyspnoea | 41.75 | 9.89 | 2511 | 189968 | 545097 | 49867548 |
Sopor | 41.53 | 9.89 | 12 | 192467 | 19867 | 50392778 |
Feeling hot | 41.26 | 9.89 | 273 | 192206 | 38929 | 50373716 |
Coronary artery disease | 40.69 | 9.89 | 32 | 192447 | 29694 | 50382951 |
Dermatitis diaper | 40.51 | 9.89 | 18 | 192461 | 173 | 50412472 |
Blood pressure systolic increased | 40.47 | 9.89 | 45 | 192434 | 35404 | 50377241 |
Impaired gastric emptying | 40.29 | 9.89 | 97 | 192382 | 8621 | 50404024 |
Anaphylactic reaction | 40.27 | 9.89 | 347 | 192132 | 53708 | 50358937 |
Oxygen saturation decreased | 40.20 | 9.89 | 441 | 192038 | 72807 | 50339838 |
Injection site pruritus | 40.19 | 9.89 | 57 | 192422 | 40354 | 50372291 |
Failure to thrive | 39.90 | 9.89 | 80 | 192399 | 6278 | 50406367 |
Otitis media chronic | 39.20 | 9.89 | 16 | 192463 | 122 | 50412523 |
Segmental diverticular colitis | 39.09 | 9.89 | 16 | 192463 | 123 | 50412522 |
Drug resistance | 38.70 | 9.89 | 12 | 192467 | 18977 | 50393668 |
Sedation | 38.19 | 9.89 | 36 | 192443 | 30574 | 50382071 |
Blister | 38.06 | 9.89 | 181 | 192298 | 85237 | 50327408 |
Back pain | 37.78 | 9.89 | 1100 | 191379 | 218930 | 50193715 |
Ill-defined disorder | 37.74 | 9.89 | 96 | 192383 | 54558 | 50358087 |
Atrial septal defect | 37.68 | 9.89 | 78 | 192401 | 6263 | 50406382 |
Product use issue | 37.58 | 9.89 | 375 | 192104 | 149100 | 50263545 |
Lactic acidosis | 37.36 | 9.89 | 43 | 192436 | 33312 | 50379333 |
Rheumatoid nodule | 37.10 | 9.89 | 3 | 192476 | 12732 | 50399913 |
Psoriasis | 37.08 | 9.89 | 136 | 192343 | 68864 | 50343781 |
C-reactive protein increased | 37.07 | 9.89 | 129 | 192350 | 66345 | 50346300 |
Respiratory syncytial virus infection | 36.68 | 9.89 | 68 | 192411 | 5034 | 50407611 |
Electrocardiogram QRS complex | 36.61 | 9.89 | 8 | 192471 | 0 | 50412645 |
Asthma | 36.56 | 9.89 | 195 | 192284 | 89142 | 50323503 |
Intentional product misuse | 36.36 | 9.89 | 77 | 192402 | 46657 | 50365988 |
Diabetes mellitus | 36.33 | 9.89 | 83 | 192396 | 48950 | 50363695 |
Product use in unapproved indication | 36.00 | 9.89 | 630 | 191849 | 115189 | 50297456 |
Pulmonary embolism | 35.96 | 9.89 | 565 | 191914 | 101139 | 50311506 |
Pneumonia | 35.67 | 9.89 | 1770 | 190709 | 376631 | 50036014 |
Infection | 35.21 | 9.89 | 455 | 192024 | 172499 | 50240146 |
Basal cell carcinoma | 34.77 | 9.89 | 23 | 192456 | 23333 | 50389312 |
Computerised tomogram thorax abnormal | 34.71 | 9.89 | 34 | 192445 | 1349 | 50411296 |
Leukopenia | 34.54 | 9.89 | 401 | 192078 | 67127 | 50345518 |
Injection site bruising | 34.48 | 9.89 | 54 | 192425 | 36714 | 50375931 |
Lupus vasculitis | 34.30 | 9.89 | 22 | 192457 | 465 | 50412180 |
Aplasia | 34.16 | 9.89 | 56 | 192423 | 3757 | 50408888 |
Cardiac arrest | 33.98 | 9.89 | 476 | 192003 | 83175 | 50329470 |
Hepatic function abnormal | 33.60 | 9.89 | 45 | 192434 | 32636 | 50380009 |
Blood potassium decreased | 33.43 | 9.89 | 248 | 192231 | 36697 | 50375948 |
Red blood cell count decreased | 32.85 | 9.89 | 231 | 192248 | 33604 | 50379041 |
Right ventricular hypertrophy | 32.63 | 9.89 | 24 | 192455 | 638 | 50412007 |
Product complaint | 32.59 | 9.89 | 3 | 192476 | 11463 | 50401182 |
Pulmonary fibrosis | 32.58 | 9.89 | 27 | 192452 | 24410 | 50388235 |
Osteonecrosis | 32.42 | 9.89 | 23 | 192456 | 22494 | 50390151 |
Unresponsive to stimuli | 32.11 | 9.89 | 213 | 192266 | 30396 | 50382249 |
Apnoea | 31.65 | 9.89 | 77 | 192402 | 6889 | 50405756 |
Pedal pulse abnormal | 31.65 | 9.89 | 14 | 192465 | 133 | 50412512 |
Wrong technique in product usage process | 31.44 | 9.89 | 107 | 192372 | 55403 | 50357242 |
Bone density decreased | 31.20 | 9.89 | 3 | 192476 | 11072 | 50401573 |
Gait disturbance | 31.13 | 9.89 | 393 | 192086 | 149612 | 50263033 |
Sinusitis | 30.68 | 9.89 | 460 | 192019 | 170098 | 50242547 |
Poor feeding infant | 30.49 | 9.89 | 16 | 192463 | 228 | 50412417 |
Joint stiffness | 29.89 | 9.89 | 43 | 192436 | 30265 | 50382380 |
Left atrial hypertrophy | 29.81 | 9.89 | 10 | 192469 | 40 | 50412605 |
Oral pain | 29.23 | 9.89 | 179 | 192300 | 24854 | 50387791 |
Sense of oppression | 29.04 | 9.89 | 26 | 192453 | 919 | 50411726 |
Neonatal tachypnoea | 28.36 | 9.89 | 10 | 192469 | 48 | 50412597 |
Renal impairment | 28.33 | 9.89 | 170 | 192309 | 75491 | 50337154 |
Vasculitis | 28.23 | 9.89 | 9 | 192470 | 13982 | 50398663 |
Hospitalisation | 27.76 | 9.89 | 387 | 192092 | 67550 | 50345095 |
Macular degeneration | 27.73 | 9.89 | 10 | 192469 | 14378 | 50398267 |
Ageusia | 27.69 | 9.89 | 102 | 192377 | 11481 | 50401164 |
Right ventricular enlargement | 27.54 | 9.89 | 16 | 192463 | 281 | 50412364 |
Laevocardia | 27.45 | 9.89 | 6 | 192473 | 0 | 50412645 |
Therapy interrupted | 27.37 | 9.89 | 150 | 192329 | 20002 | 50392643 |
Type I hypersensitivity | 26.95 | 9.89 | 39 | 192440 | 2346 | 50410299 |
International normalised ratio increased | 26.66 | 9.89 | 80 | 192399 | 43072 | 50369573 |
Chest discomfort | 26.57 | 9.89 | 498 | 191981 | 92224 | 50320421 |
Neutropenic colitis | 26.55 | 9.89 | 39 | 192440 | 2378 | 50410267 |
Otitis media acute | 26.53 | 9.89 | 24 | 192455 | 860 | 50411785 |
Joint range of motion decreased | 26.53 | 9.89 | 19 | 192460 | 18493 | 50394152 |
Sinus tachycardia | 26.40 | 9.89 | 155 | 192324 | 21199 | 50391446 |
Blood pressure fluctuation | 26.25 | 9.89 | 61 | 192418 | 35762 | 50376883 |
Toxic erythema of chemotherapy | 26.16 | 9.89 | 12 | 192467 | 125 | 50412520 |
Bronchospasm | 26.15 | 9.89 | 119 | 192360 | 14735 | 50397910 |
Clostridium difficile colitis | 26.10 | 9.89 | 135 | 192344 | 17607 | 50395038 |
Medication error | 26.04 | 9.89 | 62 | 192417 | 36042 | 50376603 |
Anaphylactic shock | 26.03 | 9.89 | 148 | 192331 | 20007 | 50392638 |
Fibromyalgia | 25.95 | 9.89 | 86 | 192393 | 44892 | 50367753 |
Acute respiratory failure | 25.92 | 9.89 | 193 | 192286 | 28589 | 50384056 |
Cestode infection | 25.40 | 9.89 | 15 | 192464 | 272 | 50412373 |
Troponin increased | 25.17 | 9.89 | 78 | 192401 | 8040 | 50404605 |
Rhabdomyolysis | 25.09 | 9.89 | 71 | 192408 | 38956 | 50373689 |
Taste disorder | 24.90 | 9.89 | 79 | 192400 | 8245 | 50404400 |
Pulmonary artery stenosis congenital | 24.81 | 9.89 | 14 | 192465 | 232 | 50412413 |
Foot deformity | 24.67 | 9.89 | 22 | 192457 | 19188 | 50393457 |
Therapy non-responder | 24.59 | 9.89 | 105 | 192374 | 50917 | 50361728 |
Bacteraemia | 24.21 | 9.89 | 114 | 192365 | 14319 | 50398326 |
Eustachian tube dysfunction | 24.11 | 9.89 | 16 | 192463 | 359 | 50412286 |
Pain in extremity | 24.08 | 9.89 | 823 | 191656 | 272042 | 50140603 |
Epistaxis | 24.02 | 9.89 | 359 | 192120 | 63595 | 50349050 |
Feeding intolerance | 23.76 | 9.89 | 18 | 192461 | 501 | 50412144 |
Gangrene | 23.64 | 9.89 | 54 | 192425 | 4638 | 50408007 |
Cerebral microhaemorrhage | 23.47 | 9.89 | 10 | 192469 | 86 | 50412559 |
Disease recurrence | 23.47 | 9.89 | 25 | 192454 | 20056 | 50392589 |
Bone disorder | 23.45 | 9.89 | 22 | 192457 | 18730 | 50393915 |
Device related infection | 23.41 | 9.89 | 147 | 192332 | 20588 | 50392057 |
Respiratory distress | 23.37 | 9.89 | 197 | 192282 | 30292 | 50382353 |
Pneumonitis | 23.33 | 9.89 | 192 | 192287 | 29318 | 50383327 |
Vascular access site thrombosis | 23.28 | 9.89 | 8 | 192471 | 35 | 50412610 |
Bursitis | 23.24 | 9.89 | 30 | 192449 | 22105 | 50390540 |
Sedation complication | 23.12 | 9.89 | 3 | 192476 | 8763 | 50403882 |
Postural orthostatic tachycardia syndrome | 22.94 | 9.89 | 22 | 192457 | 850 | 50411795 |
Chest pain | 22.80 | 9.89 | 855 | 191624 | 176027 | 50236618 |
Adenoidal hypertrophy | 22.26 | 9.89 | 8 | 192471 | 41 | 50412604 |
Mental status changes | 22.06 | 9.89 | 223 | 192256 | 36049 | 50376596 |
Ileus | 21.83 | 9.89 | 104 | 192375 | 13125 | 50399520 |
Drug eruption | 21.82 | 9.89 | 35 | 192444 | 23571 | 50389074 |
Contusion | 21.76 | 9.89 | 298 | 192181 | 111885 | 50300760 |
Hypophagia | 21.70 | 9.89 | 180 | 192299 | 27548 | 50385097 |
Muscle spasms | 21.60 | 9.89 | 628 | 191851 | 124925 | 50287720 |
Peripheral swelling | 21.60 | 9.89 | 607 | 191872 | 205329 | 50207316 |
Treatment noncompliance | 21.56 | 9.89 | 52 | 192427 | 30098 | 50382547 |
Metastases to meninges | 21.56 | 9.89 | 32 | 192447 | 1970 | 50410675 |
Congenital anomaly in offspring | 21.51 | 9.89 | 11 | 192468 | 148 | 50412497 |
Bone pain | 21.34 | 9.89 | 274 | 192205 | 46955 | 50365690 |
Injection site haemorrhage | 21.33 | 9.89 | 30 | 192449 | 21316 | 50391329 |
Right ventricular dilatation | 21.24 | 9.89 | 22 | 192457 | 934 | 50411711 |
Interstitial lung disease | 21.23 | 9.89 | 117 | 192362 | 53059 | 50359586 |
Hypercholesterolaemia | 21.13 | 9.89 | 9 | 192470 | 11694 | 50400951 |
Pharyngeal paraesthesia | 21.12 | 9.89 | 27 | 192452 | 1442 | 50411203 |
Laboratory test abnormal | 21.12 | 9.89 | 156 | 192323 | 23052 | 50389593 |
Cervix neoplasm | 21.10 | 9.89 | 12 | 192467 | 202 | 50412443 |
Alopecia areata | 21.03 | 9.89 | 26 | 192453 | 1342 | 50411303 |
Pancreatitis | 20.88 | 9.89 | 251 | 192228 | 42363 | 50370282 |
Administration site oedema | 20.87 | 9.89 | 7 | 192472 | 28 | 50412617 |
Fracture | 20.76 | 9.89 | 20 | 192459 | 16813 | 50395832 |
Plantar erythema | 20.64 | 9.89 | 12 | 192467 | 211 | 50412434 |
Malaise | 20.53 | 9.89 | 1511 | 190968 | 334021 | 50078624 |
Amputation stump pain | 20.49 | 9.89 | 7 | 192472 | 30 | 50412615 |
Jaundice neonatal | 20.47 | 9.89 | 20 | 192459 | 791 | 50411854 |
Depressed level of consciousness | 20.37 | 9.89 | 115 | 192364 | 51838 | 50360807 |
Neurotoxicity | 20.21 | 9.89 | 110 | 192369 | 14630 | 50398015 |
Hypervolaemia | 20.21 | 9.89 | 166 | 192313 | 25333 | 50387312 |
Glaucoma | 20.10 | 9.89 | 18 | 192461 | 15668 | 50396977 |
Blood magnesium decreased | 20.09 | 9.89 | 90 | 192389 | 11070 | 50401575 |
Product dose omission issue | 20.08 | 9.89 | 873 | 191606 | 182965 | 50229680 |
Lip pruritus | 20.03 | 9.89 | 19 | 192460 | 724 | 50411921 |
Intestinal perforation | 20 | 9.89 | 86 | 192393 | 10393 | 50402252 |
Panniculitis | 19.98 | 9.89 | 4 | 192475 | 8499 | 50404146 |
Left ventricular dysfunction | 19.88 | 9.89 | 86 | 192393 | 10420 | 50402225 |
Ventricular septal defect | 19.80 | 9.89 | 46 | 192433 | 3995 | 50408650 |
Nail pigmentation | 19.78 | 9.89 | 11 | 192468 | 177 | 50412468 |
Respiratory failure | 19.71 | 9.89 | 470 | 192009 | 90711 | 50321934 |
Burkholderia cepacia complex infection | 19.66 | 9.89 | 10 | 192469 | 133 | 50412512 |
Vascular access site infection | 19.62 | 9.89 | 7 | 192472 | 35 | 50412610 |
Gastroenteritis radiation | 19.51 | 9.89 | 15 | 192464 | 427 | 50412218 |
Hydronephrosis | 19.41 | 9.89 | 74 | 192405 | 8467 | 50404178 |
Product substitution issue | 19.41 | 9.89 | 15 | 192464 | 14042 | 50398603 |
Enterocolitis | 19.35 | 9.89 | 62 | 192417 | 6505 | 50406140 |
Lupus-like syndrome | 19.34 | 9.89 | 6 | 192473 | 9485 | 50403160 |
Eating disorder | 19.15 | 9.89 | 112 | 192367 | 15297 | 50397348 |
Pulmonary valve stenosis | 19.04 | 9.89 | 13 | 192466 | 306 | 50412339 |
Computerised tomogram thorax | 18.90 | 9.89 | 10 | 192469 | 145 | 50412500 |
Pregnancy | 18.87 | 9.89 | 54 | 192425 | 29523 | 50383122 |
Hyperemesis gravidarum | 18.82 | 9.89 | 16 | 192463 | 527 | 50412118 |
Sleep disorder | 18.76 | 9.89 | 134 | 192345 | 57149 | 50355496 |
Long QT syndrome congenital | 18.71 | 9.89 | 7 | 192472 | 41 | 50412604 |
Coma | 18.65 | 9.89 | 133 | 192346 | 56746 | 50355899 |
Congenital pulmonary valve atresia | 18.65 | 9.89 | 8 | 192471 | 70 | 50412575 |
Creatinine renal clearance decreased | 18.65 | 9.89 | 11 | 192468 | 11870 | 50400775 |
Urinary tract infection | 18.65 | 9.89 | 1036 | 191443 | 222984 | 50189661 |
Drug dependence | 18.55 | 9.89 | 29 | 192450 | 19730 | 50392915 |
Stress cardiomyopathy | 18.48 | 9.89 | 69 | 192410 | 7818 | 50404827 |
Paraesthesia | 18.43 | 9.89 | 593 | 191886 | 119650 | 50292995 |
Schizophrenia | 18.42 | 9.89 | 3 | 192476 | 7394 | 50405251 |
Weight decreased | 18.38 | 9.89 | 1023 | 191456 | 220222 | 50192423 |
Bulimia nervosa | 18.38 | 9.89 | 14 | 192465 | 393 | 50412252 |
Infective pulmonary exacerbation of cystic fibrosis | 18.37 | 9.89 | 69 | 192410 | 7840 | 50404805 |
Drug level increased | 18.35 | 9.89 | 28 | 192451 | 19240 | 50393405 |
Ventricular extrasystoles | 18.33 | 9.89 | 84 | 192395 | 10432 | 50402213 |
Univentricular heart | 18.30 | 9.89 | 4 | 192475 | 0 | 50412645 |
Subchorionic haemorrhage | 18.26 | 9.89 | 10 | 192469 | 156 | 50412489 |
Cerebellar stroke | 18.22 | 9.89 | 11 | 192468 | 208 | 50412437 |
Metastases to peritoneum | 18.20 | 9.89 | 36 | 192443 | 2797 | 50409848 |
Venoocclusive liver disease | 18.20 | 9.89 | 46 | 192433 | 4215 | 50408430 |
Cerebral infarction | 18.17 | 9.89 | 34 | 192445 | 21570 | 50391075 |
Drug interaction | 18.08 | 9.89 | 600 | 191879 | 199021 | 50213624 |
Skin ulcer | 18.07 | 9.89 | 71 | 192408 | 35247 | 50377398 |
Laryngeal discomfort | 17.97 | 9.89 | 12 | 192467 | 272 | 50412373 |
Drug clearance decreased | 17.93 | 9.89 | 22 | 192457 | 1127 | 50411518 |
Oral candidiasis | 17.92 | 9.89 | 118 | 192361 | 16797 | 50395848 |
Tryptase increased | 17.90 | 9.89 | 11 | 192468 | 215 | 50412430 |
Magnesium deficiency | 17.88 | 9.89 | 15 | 192464 | 485 | 50412160 |
Rotator cuff syndrome | 17.69 | 9.89 | 11 | 192468 | 11533 | 50401112 |
Injection site warmth | 17.66 | 9.89 | 16 | 192463 | 13850 | 50398795 |
Poisoning | 17.49 | 9.89 | 13 | 192466 | 12416 | 50400229 |
Transfusion | 17.49 | 9.89 | 96 | 192383 | 12809 | 50399836 |
Illness | 17.47 | 9.89 | 156 | 192323 | 24384 | 50388261 |
Peripheral sensory neuropathy | 17.44 | 9.89 | 60 | 192419 | 6531 | 50406114 |
Infusion site streaking | 17.30 | 9.89 | 14 | 192465 | 430 | 50412215 |
Skin necrosis | 17.15 | 9.89 | 10 | 192469 | 10857 | 50401788 |
Onychalgia | 17.13 | 9.89 | 18 | 192461 | 777 | 50411868 |
Electrolyte imbalance | 17.12 | 9.89 | 118 | 192361 | 17051 | 50395594 |
Toxic encephalopathy | 17.10 | 9.89 | 53 | 192426 | 5462 | 50407183 |
Paranoia | 17.08 | 9.89 | 9 | 192470 | 10339 | 50402306 |
Dysphemia | 16.91 | 9.89 | 31 | 192448 | 2275 | 50410370 |
Non-cardiac chest pain | 16.78 | 9.89 | 54 | 192425 | 5678 | 50406967 |
Procedural vomiting | 16.71 | 9.89 | 14 | 192465 | 452 | 50412193 |
Obstructive airways disorder | 16.66 | 9.89 | 21 | 192458 | 15631 | 50397014 |
Osteomyelitis | 16.43 | 9.89 | 38 | 192441 | 22315 | 50390330 |
Immune effector cell-associated neurotoxicity syndrome | 16.32 | 9.89 | 21 | 192458 | 1129 | 50411516 |
Poor peripheral circulation | 16.25 | 9.89 | 37 | 192442 | 3171 | 50409474 |
Sleep disorder due to a general medical condition | 16.25 | 9.89 | 4 | 192475 | 7367 | 50405278 |
Tendonitis | 16.18 | 9.89 | 24 | 192455 | 16681 | 50395964 |
Premature delivery | 16.12 | 9.89 | 149 | 192330 | 23514 | 50389131 |
Gastrostomy tube site complication | 16.08 | 9.89 | 4 | 192475 | 3 | 50412642 |
Congenital tongue anomaly | 16.08 | 9.89 | 4 | 192475 | 3 | 50412642 |
Dry skin | 16.04 | 9.89 | 242 | 192237 | 42949 | 50369696 |
Incorrect route of product administration | 16.04 | 9.89 | 29 | 192450 | 18637 | 50394008 |
Hypergeusia | 16.00 | 9.89 | 5 | 192474 | 15 | 50412630 |
Cleft palate | 15.94 | 9.89 | 19 | 192460 | 944 | 50411701 |
Epiglottic oedema | 15.92 | 9.89 | 6 | 192473 | 36 | 50412609 |
Vein discolouration | 15.90 | 9.89 | 10 | 192469 | 204 | 50412441 |
Madarosis | 15.81 | 9.89 | 32 | 192447 | 2528 | 50410117 |
Feeding disorder | 15.78 | 9.89 | 81 | 192398 | 10532 | 50402113 |
Electrolyte depletion | 15.75 | 9.89 | 9 | 192470 | 153 | 50412492 |
Carpal tunnel syndrome | 15.66 | 9.89 | 25 | 192454 | 16868 | 50395777 |
Migraine | 15.65 | 9.89 | 386 | 192093 | 74894 | 50337751 |
Right ventricle outflow tract obstruction | 15.55 | 9.89 | 4 | 192475 | 4 | 50412641 |
Pityriasis rosea | 15.51 | 9.89 | 7 | 192472 | 70 | 50412575 |
Hyperkalaemia | 15.50 | 9.89 | 113 | 192366 | 47976 | 50364669 |
Seizure like phenomena | 15.40 | 9.89 | 19 | 192460 | 979 | 50411666 |
Blood bilirubin increased | 15.38 | 9.89 | 188 | 192291 | 31850 | 50380795 |
Muscle twitching | 15.36 | 9.89 | 106 | 192373 | 15325 | 50397320 |
Full blood count abnormal | 15.30 | 9.89 | 146 | 192333 | 23242 | 50389403 |
Premenstrual syndrome | 15.28 | 9.89 | 15 | 192464 | 597 | 50412048 |
Hypersensitivity | 15.22 | 9.89 | 666 | 191813 | 214495 | 50198150 |
Electrocardiogram PR shortened | 15.16 | 9.89 | 10 | 192469 | 222 | 50412423 |
Hot flush | 15.08 | 9.89 | 244 | 192235 | 43925 | 50368720 |
Melaena | 15.06 | 9.89 | 52 | 192427 | 26812 | 50385833 |
Thrombosis | 15.01 | 9.89 | 297 | 192182 | 55536 | 50357109 |
Musculoskeletal pain | 14.99 | 9.89 | 189 | 192290 | 71988 | 50340657 |
Plasmacytoma | 14.96 | 9.89 | 30 | 192449 | 2355 | 50410290 |
Transplant rejection | 14.94 | 9.89 | 9 | 192470 | 9600 | 50403045 |
Tracheal injury | 14.90 | 9.89 | 6 | 192473 | 44 | 50412601 |
Joint dislocation | 14.81 | 9.89 | 15 | 192464 | 12318 | 50400327 |
Anaphylactoid reaction | 14.79 | 9.89 | 37 | 192442 | 3369 | 50409276 |
Electrocardiogram T wave inversion | 14.77 | 9.89 | 36 | 192443 | 3225 | 50409420 |
Lipase decreased | 14.71 | 9.89 | 8 | 192471 | 123 | 50412522 |
Monocyte count decreased | 14.66 | 9.89 | 26 | 192453 | 1860 | 50410785 |
Glioblastoma multiforme | 14.66 | 9.89 | 16 | 192463 | 722 | 50411923 |
Liver injury | 14.60 | 9.89 | 47 | 192432 | 24759 | 50387886 |
Chronic hepatitis B | 14.47 | 9.89 | 9 | 192470 | 180 | 50412465 |
Food intolerance | 14.45 | 9.89 | 30 | 192449 | 2414 | 50410231 |
Rash maculo-papular | 14.43 | 9.89 | 160 | 192319 | 26481 | 50386164 |
Alopecia totalis | 14.37 | 9.89 | 11 | 192468 | 311 | 50412334 |
Stridor | 14.37 | 9.89 | 35 | 192444 | 3134 | 50409511 |
Joint effusion | 14.35 | 9.89 | 17 | 192462 | 13004 | 50399641 |
Neutrophil count abnormal | 14.32 | 9.89 | 30 | 192449 | 2429 | 50410216 |
Right-to-left cardiac shunt | 14.25 | 9.89 | 9 | 192470 | 185 | 50412460 |
Uterine perforation | 14.10 | 9.89 | 55 | 192424 | 6360 | 50406285 |
Herpes zoster | 14.10 | 9.89 | 187 | 192292 | 70599 | 50342046 |
Aphasia | 14.03 | 9.89 | 168 | 192311 | 28326 | 50384319 |
Transmission of an infectious agent via product | 14.00 | 9.89 | 8 | 192471 | 136 | 50412509 |
IIIrd nerve paresis | 14.00 | 9.89 | 8 | 192471 | 136 | 50412509 |
Uterine contractions during pregnancy | 13.96 | 9.89 | 13 | 192466 | 484 | 50412161 |
Gait inability | 13.96 | 9.89 | 83 | 192396 | 36944 | 50375701 |
Streptococcal bacteraemia | 13.86 | 9.89 | 22 | 192457 | 1436 | 50411209 |
Gastroenteropancreatic neuroendocrine tumour disease | 13.85 | 9.89 | 5 | 192474 | 26 | 50412619 |
Hypofibrinogenaemia | 13.78 | 9.89 | 19 | 192460 | 1093 | 50411552 |
Cytopenia | 13.77 | 9.89 | 68 | 192411 | 8707 | 50403938 |
Abdominal distension | 13.75 | 9.89 | 369 | 192110 | 72534 | 50340111 |
Wolff-Parkinson-White syndrome congenital | 13.73 | 9.89 | 3 | 192476 | 0 | 50412645 |
Pulmonary oedema neonatal | 13.73 | 9.89 | 3 | 192476 | 0 | 50412645 |
Foetal damage | 13.73 | 9.89 | 3 | 192476 | 0 | 50412645 |
Oedema neonatal | 13.73 | 9.89 | 3 | 192476 | 0 | 50412645 |
Right ventricular hypertension | 13.73 | 9.89 | 3 | 192476 | 0 | 50412645 |
Myocardial reperfusion injury | 13.70 | 9.89 | 5 | 192474 | 27 | 50412618 |
Septic shock | 13.69 | 9.89 | 299 | 192180 | 56876 | 50355769 |
Hepatocellular injury | 13.67 | 9.89 | 155 | 192324 | 25792 | 50386853 |
Cytomegalovirus infection | 13.63 | 9.89 | 30 | 192449 | 17932 | 50394713 |
Dacryostenosis congenital | 13.62 | 9.89 | 4 | 192475 | 9 | 50412636 |
Pulmonary valve stenosis congenital | 13.55 | 9.89 | 8 | 192471 | 145 | 50412500 |
Hyperbilirubinaemia neonatal | 13.51 | 9.89 | 11 | 192468 | 341 | 50412304 |
Tumour lysis syndrome | 13.48 | 9.89 | 60 | 192419 | 7361 | 50405284 |
Protein urine | 13.45 | 9.89 | 14 | 192465 | 598 | 50412047 |
Anomalous pulmonary venous connection | 13.38 | 9.89 | 6 | 192473 | 59 | 50412586 |
Capillary leak syndrome | 13.35 | 9.89 | 25 | 192454 | 1865 | 50410780 |
Generalised tonic-clonic seizure | 13.34 | 9.89 | 156 | 192323 | 26154 | 50386491 |
Ejection fraction decreased | 13.32 | 9.89 | 118 | 192361 | 18402 | 50394243 |
Uterine hypotonus | 13.26 | 9.89 | 7 | 192472 | 101 | 50412544 |
Right atrial enlargement | 13.20 | 9.89 | 7 | 192472 | 102 | 50412543 |
Delirium | 13.17 | 9.89 | 88 | 192391 | 38104 | 50374541 |
Exostosis | 13.07 | 9.89 | 15 | 192464 | 11638 | 50401007 |
Developmental delay | 12.96 | 9.89 | 20 | 192459 | 1274 | 50411371 |
Neuroleptic malignant syndrome | 12.84 | 9.89 | 14 | 192465 | 11116 | 50401529 |
Haematoma | 12.81 | 9.89 | 66 | 192413 | 30444 | 50382201 |
Drug reaction with eosinophilia and systemic symptoms | 12.79 | 9.89 | 60 | 192419 | 28364 | 50384281 |
Blood pressure diastolic decreased | 12.76 | 9.89 | 28 | 192451 | 16753 | 50395892 |
Dementia | 12.74 | 9.89 | 26 | 192453 | 15971 | 50396674 |
Pathogen resistance | 12.71 | 9.89 | 3 | 192476 | 5686 | 50406959 |
Grunting | 12.68 | 9.89 | 9 | 192470 | 226 | 50412419 |
Stress | 12.67 | 9.89 | 137 | 192342 | 53656 | 50358989 |
Gastroenteritis viral | 12.65 | 9.89 | 118 | 192361 | 18668 | 50393977 |
Hyperlipidaemia | 12.64 | 9.89 | 30 | 192449 | 17460 | 50395185 |
Neuralgia | 12.62 | 9.89 | 133 | 192346 | 21730 | 50390915 |
Nail infection | 12.52 | 9.89 | 25 | 192454 | 1956 | 50410689 |
Cardiac murmur | 12.52 | 9.89 | 77 | 192402 | 10707 | 50401938 |
Aggression | 12.44 | 9.89 | 40 | 192439 | 21076 | 50391569 |
Deep vein thrombosis | 12.42 | 9.89 | 366 | 192113 | 72938 | 50339707 |
Injection site urticaria | 12.38 | 9.89 | 17 | 192462 | 12200 | 50400445 |
Dextrocardia | 12.34 | 9.89 | 4 | 192475 | 14 | 50412631 |
Stoma obstruction | 12.34 | 9.89 | 4 | 192475 | 14 | 50412631 |
Orthostatic hypotension | 12.25 | 9.89 | 64 | 192415 | 29417 | 50383228 |
Periorbital cellulitis | 12.25 | 9.89 | 13 | 192466 | 568 | 50412077 |
Acute coronary syndrome | 12.21 | 9.89 | 69 | 192410 | 9305 | 50403340 |
Injection site phlebitis | 12.20 | 9.89 | 7 | 192472 | 120 | 50412525 |
Anaesthetic complication neurological | 12.19 | 9.89 | 8 | 192471 | 176 | 50412469 |
Cyanosis | 12.11 | 9.89 | 99 | 192380 | 15085 | 50397560 |
Electrocardiogram QT shortened | 12.10 | 9.89 | 7 | 192472 | 122 | 50412523 |
Multiple fractures | 12.07 | 9.89 | 5 | 192474 | 6606 | 50406039 |
Otorrhoea | 12.01 | 9.89 | 19 | 192460 | 1237 | 50411408 |
Skin burning sensation | 12.00 | 9.89 | 73 | 192406 | 10112 | 50402533 |
Cytotoxic oedema | 11.95 | 9.89 | 7 | 192472 | 125 | 50412520 |
Congenital tricuspid valve atresia | 11.94 | 9.89 | 5 | 192474 | 41 | 50412604 |
Haemoglobin decreased | 11.92 | 9.89 | 595 | 191884 | 126621 | 50286024 |
Eye irritation | 11.91 | 9.89 | 30 | 192449 | 17110 | 50395535 |
Acute myeloid leukaemia | 11.87 | 9.89 | 98 | 192381 | 14976 | 50397669 |
Sensitivity to weather change | 11.86 | 9.89 | 4 | 192475 | 5997 | 50406648 |
Hallucination, auditory | 11.83 | 9.89 | 14 | 192465 | 10714 | 50401931 |
Abdominal infection | 11.76 | 9.89 | 22 | 192457 | 1640 | 50411005 |
Disability | 11.75 | 9.89 | 19 | 192460 | 12756 | 50399889 |
COVID-19 pneumonia | 11.75 | 9.89 | 63 | 192416 | 8332 | 50404313 |
Liver disorder | 11.74 | 9.89 | 88 | 192391 | 37134 | 50375511 |
Teething | 11.73 | 9.89 | 4 | 192475 | 17 | 50412628 |
Coronary artery occlusion | 11.70 | 9.89 | 7 | 192472 | 7496 | 50405149 |
Device malfunction | 11.69 | 9.89 | 25 | 192454 | 15096 | 50397549 |
Hyperhidrosis | 11.68 | 9.89 | 433 | 192046 | 88993 | 50323652 |
Vascular device infection | 11.68 | 9.89 | 40 | 192439 | 4344 | 50408301 |
Pregnancy with advanced maternal age | 11.66 | 9.89 | 3 | 192476 | 3 | 50412642 |
Right atrial dilatation | 11.64 | 9.89 | 13 | 192466 | 602 | 50412043 |
Malnutrition | 11.63 | 9.89 | 88 | 192391 | 13101 | 50399544 |
Myoglobinuria | 11.62 | 9.89 | 9 | 192470 | 259 | 50412386 |
Neutrophil percentage abnormal | 11.55 | 9.89 | 4 | 192475 | 18 | 50412627 |
Procedural nausea | 11.55 | 9.89 | 14 | 192465 | 708 | 50411937 |
Blood pressure diastolic increased | 11.53 | 9.89 | 7 | 192472 | 7436 | 50405209 |
Glycosylated haemoglobin increased | 11.53 | 9.89 | 14 | 192465 | 10592 | 50402053 |
Pallor | 11.52 | 9.89 | 137 | 192342 | 23062 | 50389583 |
Alveolitis | 11.50 | 9.89 | 28 | 192451 | 2506 | 50410139 |
Palmar erythema | 11.45 | 9.89 | 21 | 192458 | 1542 | 50411103 |
Cyclic vomiting syndrome | 11.44 | 9.89 | 5 | 192474 | 46 | 50412599 |
Renal function test abnormal | 11.39 | 9.89 | 30 | 192449 | 2819 | 50409826 |
Fever neonatal | 11.38 | 9.89 | 4 | 192475 | 19 | 50412626 |
Exposure during pregnancy | 11.36 | 9.89 | 362 | 192117 | 120653 | 50291992 |
Intercepted product administration error | 11.34 | 9.89 | 6 | 192473 | 87 | 50412558 |
Hair texture abnormal | 11.21 | 9.89 | 35 | 192444 | 3621 | 50409024 |
Arterial occlusive disease | 11.21 | 9.89 | 42 | 192437 | 4766 | 50407879 |
Congenital anaemia | 11.20 | 9.89 | 3 | 192476 | 4 | 50412641 |
Cleft lip and palate | 11.18 | 9.89 | 10 | 192469 | 353 | 50412292 |
Grip strength decreased | 11.18 | 9.89 | 18 | 192461 | 12103 | 50400542 |
Cancer pain | 11.12 | 9.89 | 28 | 192451 | 2559 | 50410086 |
Coeliac disease | 11.09 | 9.89 | 10 | 192469 | 8675 | 50403970 |
Pneumonia respiratory syncytial viral | 11.05 | 9.89 | 13 | 192466 | 637 | 50412008 |
Haemorrhoids | 11.04 | 9.89 | 116 | 192363 | 18937 | 50393708 |
Lymphorrhoea | 10.99 | 9.89 | 5 | 192474 | 51 | 50412594 |
Ventricular hypoplasia | 10.95 | 9.89 | 7 | 192472 | 147 | 50412498 |
Meningitis streptococcal | 10.95 | 9.89 | 7 | 192472 | 147 | 50412498 |
Velopharyngeal incompetence | 10.90 | 9.89 | 4 | 192475 | 22 | 50412623 |
Intentional underdose | 10.89 | 9.89 | 21 | 192458 | 1601 | 50411044 |
Polymenorrhoea | 10.89 | 9.89 | 17 | 192462 | 1094 | 50411551 |
Intensive care | 10.89 | 9.89 | 9 | 192470 | 285 | 50412360 |
Weight gain poor | 10.88 | 9.89 | 14 | 192465 | 753 | 50411892 |
Hypoglycaemia | 10.87 | 9.89 | 141 | 192338 | 53440 | 50359205 |
Arteriospasm coronary | 10.84 | 9.89 | 33 | 192446 | 3369 | 50409276 |
Blood creatine increased | 10.83 | 9.89 | 42 | 192437 | 4845 | 50407800 |
Lymphocyte count decreased | 10.80 | 9.89 | 150 | 192329 | 26157 | 50386488 |
Breast cancer metastatic | 10.80 | 9.89 | 72 | 192407 | 10292 | 50402353 |
Hallucination, visual | 10.78 | 9.89 | 30 | 192449 | 16552 | 50396093 |
Moaning | 10.78 | 9.89 | 14 | 192465 | 760 | 50411885 |
Pulmonary air leakage | 10.75 | 9.89 | 4 | 192475 | 23 | 50412622 |
Tracheal deviation | 10.74 | 9.89 | 5 | 192474 | 54 | 50412591 |
Arteriosclerosis coronary artery | 10.73 | 9.89 | 8 | 192471 | 7628 | 50405017 |
Incorrect dose administered | 10.73 | 9.89 | 125 | 192354 | 48289 | 50364356 |
Ulcer | 10.73 | 9.89 | 40 | 192439 | 20160 | 50392485 |
Injection site rash | 10.72 | 9.89 | 29 | 192450 | 16148 | 50396497 |
Tricuspid valve disease | 10.71 | 9.89 | 8 | 192471 | 218 | 50412427 |
Chronic obstructive pulmonary disease | 10.70 | 9.89 | 141 | 192338 | 53294 | 50359351 |
Hypothyroidism | 10.61 | 9.89 | 81 | 192398 | 34044 | 50378601 |
Coma scale abnormal | 10.57 | 9.89 | 41 | 192438 | 4730 | 50407915 |
Sputum abnormal | 10.54 | 9.89 | 11 | 192468 | 471 | 50412174 |
Pericardial effusion | 10.54 | 9.89 | 146 | 192333 | 25443 | 50387202 |
Biliary catheter insertion | 10.47 | 9.89 | 4 | 192475 | 25 | 50412620 |
Intentional product use issue | 10.45 | 9.89 | 218 | 192261 | 76700 | 50335945 |
Pneumomediastinum | 10.42 | 9.89 | 17 | 192462 | 1136 | 50411509 |
Injection site haematoma | 10.41 | 9.89 | 5 | 192474 | 6055 | 50406590 |
Pulse absent | 10.40 | 9.89 | 41 | 192438 | 4765 | 50407880 |
Biliary obstruction | 10.39 | 9.89 | 26 | 192453 | 2367 | 50410278 |
Wheelchair user | 10.39 | 9.89 | 3 | 192476 | 4969 | 50407676 |
Infusion related reaction | 10.36 | 9.89 | 533 | 191946 | 169024 | 50243621 |
Complication of device insertion | 10.35 | 9.89 | 5 | 192474 | 6036 | 50406609 |
Blood magnesium abnormal | 10.32 | 9.89 | 11 | 192468 | 483 | 50412162 |
Sciatica | 10.30 | 9.89 | 44 | 192435 | 21338 | 50391307 |
Dysphagia | 10.28 | 9.89 | 376 | 192103 | 77142 | 50335503 |
Acute kidney injury | 10.28 | 9.89 | 1004 | 191475 | 227054 | 50185591 |
Cleft lip | 10.25 | 9.89 | 6 | 192473 | 107 | 50412538 |
High density lipoprotein abnormal | 10.21 | 9.89 | 5 | 192474 | 61 | 50412584 |
Vocal cord paralysis | 10.20 | 9.89 | 21 | 192458 | 1680 | 50410965 |
Tumour marker increased | 10.20 | 9.89 | 35 | 192444 | 3805 | 50408840 |
Gastrointestinal motility disorder | 10.19 | 9.89 | 39 | 192440 | 4470 | 50408175 |
Tongue disorder | 10.19 | 9.89 | 12 | 192467 | 9204 | 50403441 |
Osteopenia | 10.19 | 9.89 | 32 | 192447 | 16986 | 50395659 |
Pulmonary thrombosis | 10.15 | 9.89 | 56 | 192423 | 7485 | 50405160 |
Cephalhaematoma | 10.14 | 9.89 | 3 | 192476 | 7 | 50412638 |
Enteritis | 10.13 | 9.89 | 53 | 192426 | 6942 | 50405703 |
Unintentional medical device removal | 10.10 | 9.89 | 4 | 192475 | 5431 | 50407214 |
Catheter site bruise | 10.08 | 9.89 | 9 | 192470 | 317 | 50412328 |
Systemic inflammatory response syndrome | 10.07 | 9.89 | 42 | 192437 | 5007 | 50407638 |
Cough | 9.99 | 9.89 | 1056 | 191423 | 240208 | 50172437 |
Aortic embolus | 9.97 | 9.89 | 4 | 192475 | 29 | 50412616 |
Pemphigoid | 9.96 | 9.89 | 5 | 192474 | 5902 | 50406743 |
Pharyngeal hypoaesthesia | 9.93 | 9.89 | 8 | 192471 | 244 | 50412401 |
Dysuria | 9.93 | 9.89 | 158 | 192321 | 28346 | 50384299 |
Large intestine polyp | 9.90 | 9.89 | 8 | 192471 | 7324 | 50405321 |
Gastrointestinal haemorrhage | 9.90 | 9.89 | 208 | 192271 | 73113 | 50339532 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 639.34 | 10.58 | 1347 | 110194 | 110893 | 29352093 |
Vomiting | 404.46 | 10.58 | 1726 | 109815 | 210534 | 29252452 |
Drug ineffective | 311.80 | 10.58 | 560 | 110981 | 362610 | 29100376 |
Nausea | 292.32 | 10.58 | 1976 | 109565 | 287279 | 29175707 |
Completed suicide | 230.78 | 10.58 | 33 | 111508 | 90213 | 29372773 |
Drug abuse | 230.13 | 10.58 | 19 | 111522 | 79864 | 29383122 |
Toxicity to various agents | 200.22 | 10.58 | 216 | 111325 | 173445 | 29289541 |
Serotonin syndrome | 166.63 | 10.58 | 263 | 111278 | 17249 | 29445737 |
Left-to-right cardiac shunt | 148.02 | 10.58 | 35 | 111506 | 15 | 29462971 |
Pyrexia | 134.68 | 10.58 | 1665 | 109876 | 285957 | 29177029 |
Neutropenia | 131.17 | 10.58 | 898 | 110643 | 130813 | 29332173 |
Constipation | 126.80 | 10.58 | 800 | 110741 | 113360 | 29349626 |
Diarrhoea | 124.21 | 10.58 | 1849 | 109692 | 330849 | 29132137 |
Fatigue | 122.66 | 10.58 | 1772 | 109769 | 315049 | 29147937 |
Plasma cell myeloma | 118.37 | 10.58 | 358 | 111183 | 36757 | 29426229 |
Cytokine release syndrome | 115.21 | 10.58 | 190 | 111351 | 12929 | 29450057 |
Myocardial infarction | 111.27 | 10.58 | 152 | 111389 | 110144 | 29352842 |
Febrile bone marrow aplasia | 109.66 | 10.58 | 137 | 111404 | 7214 | 29455772 |
Aplastic anaemia | 101.08 | 10.58 | 133 | 111408 | 7377 | 29455609 |
Heart disease congenital | 98.57 | 10.58 | 61 | 111480 | 1219 | 29461767 |
Otitis media chronic | 96.37 | 10.58 | 27 | 111514 | 48 | 29462938 |
Thrombocytopenia | 93.68 | 10.58 | 846 | 110695 | 133977 | 29329009 |
Abdominal pain | 91.33 | 10.58 | 844 | 110697 | 134513 | 29328473 |
Overdose | 89.92 | 10.58 | 101 | 111440 | 79718 | 29383268 |
Rhabdomyolysis | 89.02 | 10.58 | 60 | 111481 | 60748 | 29402238 |
Congenital anomaly | 84.22 | 10.58 | 56 | 111485 | 1272 | 29461714 |
Dehydration | 83.79 | 10.58 | 728 | 110813 | 114020 | 29348966 |
Suicide attempt | 83.65 | 10.58 | 14 | 111527 | 34096 | 29428890 |
Condition aggravated | 81.48 | 10.58 | 281 | 111260 | 146014 | 29316972 |
Electrocardiogram QT prolonged | 79.54 | 10.58 | 308 | 111233 | 35829 | 29427157 |
Appendicolith | 77.75 | 10.58 | 80 | 111461 | 3400 | 29459586 |
Intentional overdose | 76.37 | 10.58 | 25 | 111516 | 38503 | 29424483 |
Coronary artery disease | 75.57 | 10.58 | 36 | 111505 | 44154 | 29418832 |
Chills | 74.96 | 10.58 | 493 | 111048 | 70807 | 29392179 |
Blood creatine phosphokinase increased | 72.81 | 10.58 | 31 | 111510 | 40613 | 29422373 |
Disease progression | 71.28 | 10.58 | 541 | 111000 | 81375 | 29381611 |
Flushing | 69.52 | 10.58 | 254 | 111287 | 28738 | 29434248 |
Sepsis | 69.05 | 10.58 | 832 | 110709 | 141850 | 29321136 |
Rheumatoid arthritis | 68.97 | 10.58 | 18 | 111523 | 32134 | 29430852 |
Mucosal inflammation | 68.48 | 10.58 | 268 | 111273 | 31327 | 29431659 |
Failure to thrive | 67.07 | 10.58 | 111 | 111430 | 7573 | 29455413 |
Therapeutic product effect incomplete | 65.72 | 10.58 | 33 | 111508 | 39272 | 29423714 |
Decreased appetite | 64.53 | 10.58 | 834 | 110707 | 144508 | 29318478 |
Hospice care | 62.47 | 10.58 | 86 | 111455 | 4982 | 29458004 |
Drug resistance | 62.33 | 10.58 | 5 | 111536 | 21535 | 29441451 |
Torsade de pointes | 60.55 | 10.58 | 98 | 111443 | 6563 | 29456423 |
Erythema | 57.93 | 10.58 | 485 | 111056 | 75121 | 29387865 |
Death | 56.03 | 10.58 | 1686 | 109855 | 340398 | 29122588 |
Treatment failure | 54.65 | 10.58 | 36 | 111505 | 36903 | 29426083 |
Arthralgia | 53.07 | 10.58 | 309 | 111232 | 139308 | 29323678 |
White blood cell count decreased | 52.26 | 10.58 | 512 | 111029 | 82850 | 29380136 |
Hypoxia | 50.61 | 10.58 | 329 | 111212 | 47050 | 29415936 |
Appendicitis | 49.32 | 10.58 | 105 | 111436 | 8674 | 29454312 |
Interstitial lung disease | 49.16 | 10.58 | 89 | 111452 | 57629 | 29405357 |
Hepatic function abnormal | 47.18 | 10.58 | 47 | 111494 | 39212 | 29423774 |
Aggression | 46.94 | 10.58 | 39 | 111502 | 35502 | 29427484 |
Musculoskeletal stiffness | 45.99 | 10.58 | 44 | 111497 | 37414 | 29425572 |
Aplasia | 45.71 | 10.58 | 66 | 111475 | 3997 | 29458989 |
Neuropathy peripheral | 43.90 | 10.58 | 435 | 111106 | 70592 | 29392394 |
Tachycardia | 43.08 | 10.58 | 440 | 111101 | 71970 | 29391016 |
Ventricular tachyarrhythmia | 41.61 | 10.58 | 21 | 111520 | 277 | 29462709 |
Suicidal ideation | 41.21 | 10.58 | 42 | 111499 | 34674 | 29428312 |
Encephalopathy | 41.10 | 10.58 | 228 | 111313 | 30815 | 29432171 |
Neutrophil count decreased | 40.86 | 10.58 | 293 | 111248 | 43274 | 29419712 |
Stomatitis | 40.42 | 10.58 | 259 | 111282 | 36854 | 29426132 |
Wrong technique in product usage process | 39.66 | 10.58 | 36 | 111505 | 31392 | 29431594 |
Psoriasis | 39.39 | 10.58 | 38 | 111503 | 32189 | 29430797 |
Eustachian tube dysfunction | 39.27 | 10.58 | 13 | 111528 | 50 | 29462936 |
Right ventricular hypertrophy | 38.03 | 10.58 | 33 | 111508 | 1128 | 29461858 |
Full blood count decreased | 37.39 | 10.58 | 139 | 111402 | 15853 | 29447133 |
Hypersensitivity | 37.17 | 10.58 | 333 | 111208 | 52570 | 29410416 |
Laevocardia | 36.67 | 10.58 | 8 | 111533 | 0 | 29462986 |
Coma | 36.18 | 10.58 | 58 | 111483 | 39392 | 29423594 |
Small intestinal obstruction | 36.13 | 10.58 | 120 | 111421 | 12941 | 29450045 |
Acute myocardial infarction | 35.85 | 10.58 | 81 | 111460 | 48357 | 29414629 |
Intentional product misuse | 35.68 | 10.58 | 47 | 111494 | 34614 | 29428372 |
Therapeutic response decreased | 35.32 | 10.58 | 25 | 111516 | 24686 | 29438300 |
Otitis media acute | 35.23 | 10.58 | 22 | 111519 | 447 | 29462539 |
Myalgia | 34.83 | 10.58 | 152 | 111389 | 73867 | 29389119 |
Depression | 34.75 | 10.58 | 184 | 111357 | 84963 | 29378023 |
Right ventricular enlargement | 34.49 | 10.58 | 16 | 111525 | 173 | 29462813 |
Malignant neoplasm progression | 34.48 | 10.58 | 428 | 111113 | 73431 | 29389555 |
Ventricular fibrillation | 34.05 | 10.58 | 134 | 111407 | 15699 | 29447287 |
Cardiac failure congestive | 33.81 | 10.58 | 161 | 111380 | 76420 | 29386566 |
Adenoidal hypertrophy | 33.31 | 10.58 | 14 | 111527 | 117 | 29462869 |
Drug dependence | 33.04 | 10.58 | 19 | 111522 | 20962 | 29442024 |
Inappropriate schedule of product administration | 32.40 | 10.58 | 75 | 111466 | 44397 | 29418589 |
Atelectasis neonatal | 32.09 | 10.58 | 7 | 111534 | 0 | 29462986 |
Diabetes mellitus | 31.65 | 10.58 | 64 | 111477 | 39767 | 29423219 |
Malignant catatonia | 31.44 | 10.58 | 16 | 111525 | 215 | 29462771 |
Renal impairment | 31.41 | 10.58 | 179 | 111362 | 81154 | 29381832 |
Platelet count decreased | 31.39 | 10.58 | 562 | 110979 | 104110 | 29358876 |
Dry skin | 31.39 | 10.58 | 172 | 111369 | 23135 | 29439851 |
Therapeutic product effect decreased | 31.28 | 10.58 | 39 | 111502 | 29412 | 29433574 |
Oropharyngeal discomfort | 30.94 | 10.58 | 43 | 111498 | 2513 | 29460473 |
Intentional self-injury | 30.80 | 10.58 | 5 | 111536 | 12456 | 29450530 |
Weight increased | 30.54 | 10.58 | 167 | 111374 | 76500 | 29386486 |
Injection site pain | 30.42 | 10.58 | 47 | 111494 | 32399 | 29430587 |
Bacteraemia | 30.27 | 10.58 | 132 | 111409 | 16191 | 29446795 |
Cerebral infarction | 30.27 | 10.58 | 29 | 111512 | 24646 | 29438340 |
Pulmonary artery stenosis congenital | 29.63 | 10.58 | 20 | 111521 | 466 | 29462520 |
Anaphylactic reaction | 29.15 | 10.58 | 191 | 111350 | 27382 | 29435604 |
Negative pressure pulmonary oedema | 29.06 | 10.58 | 15 | 111526 | 208 | 29462778 |
Impaired gastric emptying | 29.04 | 10.58 | 46 | 111495 | 3024 | 29459962 |
Oral pain | 28.92 | 10.58 | 89 | 111452 | 9218 | 29453768 |
Oxygen saturation immeasurable | 28.88 | 10.58 | 9 | 111532 | 27 | 29462959 |
Colitis | 28.63 | 10.58 | 209 | 111332 | 31039 | 29431947 |
Pneumonia | 28.58 | 10.58 | 1478 | 110063 | 318694 | 29144292 |
Cleft palate | 28.56 | 10.58 | 21 | 111520 | 563 | 29462423 |
Poor feeding infant | 28.44 | 10.58 | 19 | 111522 | 435 | 29462551 |
Angina pectoris | 28.42 | 10.58 | 38 | 111503 | 27812 | 29435174 |
Psoriatic arthropathy | 28.30 | 10.58 | 10 | 111531 | 14681 | 29448305 |
Hypotension | 28.27 | 10.58 | 945 | 110596 | 193409 | 29269577 |
Clostridium difficile infection | 28.03 | 10.58 | 128 | 111413 | 16013 | 29446973 |
Right-to-left cardiac shunt | 27.79 | 10.58 | 10 | 111531 | 52 | 29462934 |
Angina unstable | 27.68 | 10.58 | 4 | 111537 | 10861 | 29452125 |
Erectile dysfunction | 27.39 | 10.58 | 17 | 111524 | 17992 | 29444994 |
Pancytopenia | 27.26 | 10.58 | 453 | 111088 | 82715 | 29380271 |
Asthma | 27.23 | 10.58 | 54 | 111487 | 33795 | 29429191 |
Atrial septal defect | 27.03 | 10.58 | 71 | 111470 | 6718 | 29456268 |
Chemotherapeutic drug level increased | 27.00 | 10.58 | 14 | 111527 | 196 | 29462790 |
Cardiac failure | 26.72 | 10.58 | 182 | 111359 | 79105 | 29383881 |
Dermatitis diaper | 26.52 | 10.58 | 15 | 111526 | 252 | 29462734 |
Asthenia | 26.50 | 10.58 | 1027 | 110514 | 214223 | 29248763 |
Blood pressure measurement | 26.48 | 10.58 | 13 | 111528 | 161 | 29462825 |
Hyperbilirubinaemia | 26.35 | 10.58 | 119 | 111422 | 14815 | 29448171 |
Hypoplastic left heart syndrome | 25.86 | 10.58 | 14 | 111527 | 215 | 29462771 |
Hyponatraemia | 25.82 | 10.58 | 378 | 111163 | 67255 | 29395731 |
Labelled drug-drug interaction medication error | 25.71 | 10.58 | 7 | 111534 | 12152 | 29450834 |
Developmental delay | 25.59 | 10.58 | 39 | 111502 | 2479 | 29460507 |
Platelet transfusion | 25.59 | 10.58 | 26 | 111515 | 1088 | 29461898 |
Croup infectious | 25.57 | 10.58 | 15 | 111526 | 271 | 29462715 |
Synovitis | 25.55 | 10.58 | 5 | 111536 | 10885 | 29452101 |
Fear | 25.41 | 10.58 | 3 | 111538 | 9501 | 29453485 |
Melaena | 24.85 | 10.58 | 50 | 111491 | 31126 | 29431860 |
Neurotoxicity | 24.72 | 10.58 | 115 | 111426 | 14498 | 29448488 |
Stridor | 24.36 | 10.58 | 36 | 111505 | 2227 | 29460759 |
Cerebrovascular accident | 24.24 | 10.58 | 180 | 111361 | 76731 | 29386255 |
Infusion related reaction | 23.89 | 10.58 | 262 | 111279 | 43624 | 29419362 |
Multiple congenital abnormalities | 23.74 | 10.58 | 18 | 111523 | 506 | 29462480 |
Gastrointestinal haemorrhage | 23.72 | 10.58 | 189 | 111352 | 79344 | 29383642 |
Loss of personal independence in daily activities | 23.71 | 10.58 | 37 | 111504 | 25403 | 29437583 |
Immune-mediated hepatitis | 23.64 | 10.58 | 29 | 111512 | 1498 | 29461488 |
Fall | 23.64 | 10.58 | 499 | 111042 | 176679 | 29286307 |
Right aortic arch | 23.53 | 10.58 | 7 | 111534 | 17 | 29462969 |
Electrocardiogram T wave biphasic | 23.27 | 10.58 | 12 | 111529 | 166 | 29462820 |
Coarctation of the aorta | 23.24 | 10.58 | 17 | 111524 | 452 | 29462534 |
Painful respiration | 22.70 | 10.58 | 25 | 111516 | 1149 | 29461837 |
Blood glucose increased | 22.66 | 10.58 | 130 | 111411 | 58854 | 29404132 |
Blood pressure fluctuation | 22.57 | 10.58 | 25 | 111516 | 19869 | 29443117 |
Altered state of consciousness | 22.55 | 10.58 | 25 | 111516 | 19864 | 29443122 |
Periorbital swelling | 22.39 | 10.58 | 15 | 111526 | 345 | 29462641 |
Upper respiratory tract infection | 22.29 | 10.58 | 178 | 111363 | 27171 | 29435815 |
Diabetes mellitus inadequate control | 22.13 | 10.58 | 9 | 111532 | 12125 | 29450861 |
Sepsis neonatal | 22.10 | 10.58 | 13 | 111528 | 236 | 29462750 |
Joint swelling | 22.09 | 10.58 | 104 | 111437 | 49526 | 29413460 |
Blood cholesterol increased | 22.00 | 10.58 | 16 | 111525 | 15579 | 29447407 |
Right ventricular dilatation | 21.86 | 10.58 | 18 | 111523 | 572 | 29462414 |
Type 2 diabetes mellitus | 21.81 | 10.58 | 12 | 111529 | 13569 | 29449417 |
Hyperthermia malignant | 21.58 | 10.58 | 30 | 111511 | 1754 | 29461232 |
Neoplasm progression | 21.57 | 10.58 | 132 | 111409 | 18480 | 29444506 |
Endocardial fibroelastosis | 21.30 | 10.58 | 6 | 111535 | 11 | 29462975 |
Cleft lip | 21.28 | 10.58 | 14 | 111527 | 312 | 29462674 |
Enteritis | 21.16 | 10.58 | 65 | 111476 | 6726 | 29456260 |
Blood triglycerides increased | 21.11 | 10.58 | 11 | 111530 | 12823 | 29450163 |
Coronary artery occlusion | 20.99 | 10.58 | 6 | 111535 | 10088 | 29452898 |
Treatment noncompliance | 20.94 | 10.58 | 37 | 111504 | 24190 | 29438796 |
Feeling hot | 20.65 | 10.58 | 114 | 111427 | 15374 | 29447612 |
Paranoia | 20.30 | 10.58 | 6 | 111535 | 9871 | 29453115 |
Post procedural hypotension | 20.25 | 10.58 | 8 | 111533 | 56 | 29462930 |
Clostridium difficile colitis | 20.20 | 10.58 | 101 | 111440 | 13111 | 29449875 |
Disturbance in attention | 20.11 | 10.58 | 31 | 111510 | 21393 | 29441593 |
Drug interaction | 20.04 | 10.58 | 579 | 110962 | 196806 | 29266180 |
Feeding disorder | 20.02 | 10.58 | 58 | 111483 | 5809 | 29457177 |
Testicular germ cell cancer metastatic | 20.01 | 10.58 | 8 | 111533 | 58 | 29462928 |
Hypoplastic right heart syndrome | 19.77 | 10.58 | 6 | 111535 | 16 | 29462970 |
Necrotising retinitis | 19.64 | 10.58 | 19 | 111522 | 749 | 29462237 |
Osteoarthritis | 19.19 | 10.58 | 24 | 111517 | 18079 | 29444907 |
Oxygen saturation decreased | 19.10 | 10.58 | 256 | 111285 | 44681 | 29418305 |
Tumour lysis syndrome | 19.06 | 10.58 | 103 | 111438 | 13781 | 29449205 |
Parainfluenzae virus infection | 18.97 | 10.58 | 32 | 111509 | 2217 | 29460769 |
Clonus | 18.96 | 10.58 | 33 | 111508 | 2345 | 29460641 |
Change of bowel habit | 18.94 | 10.58 | 21 | 111520 | 973 | 29462013 |
Skin ulcer | 18.93 | 10.58 | 26 | 111515 | 18814 | 29444172 |
Laryngeal discomfort | 18.92 | 10.58 | 10 | 111531 | 146 | 29462840 |
Klebsiella bacteraemia | 18.74 | 10.58 | 22 | 111519 | 1085 | 29461901 |
Cytomegalovirus infection | 18.70 | 10.58 | 37 | 111504 | 23178 | 29439808 |
Gastrointestinal malformation | 18.63 | 10.58 | 7 | 111534 | 42 | 29462944 |
Angioedema | 18.61 | 10.58 | 60 | 111481 | 31855 | 29431131 |
Erythropenia | 18.54 | 10.58 | 11 | 111530 | 203 | 29462783 |
Hypokalaemia | 18.53 | 10.58 | 279 | 111262 | 49924 | 29413062 |
Abnormal behaviour | 18.51 | 10.58 | 37 | 111504 | 23090 | 29439896 |
Impetigo | 18.41 | 10.58 | 20 | 111521 | 905 | 29462081 |
Embryonal rhabdomyosarcoma | 18.34 | 10.58 | 4 | 111537 | 0 | 29462986 |
Therapy non-responder | 18.10 | 10.58 | 58 | 111483 | 30853 | 29432133 |
Tubulointerstitial nephritis | 18.08 | 10.58 | 24 | 111517 | 17619 | 29445367 |
Neonatal tachypnoea | 17.95 | 10.58 | 10 | 111531 | 163 | 29462823 |
Pulse absent | 17.89 | 10.58 | 51 | 111490 | 5062 | 29457924 |
Ascites | 17.85 | 10.58 | 214 | 111327 | 36405 | 29426581 |
Prostate cancer | 17.84 | 10.58 | 44 | 111497 | 25483 | 29437503 |
Adverse drug reaction | 17.79 | 10.58 | 153 | 111388 | 23867 | 29439119 |
Psychotic disorder | 17.67 | 10.58 | 31 | 111510 | 20323 | 29442663 |
Arteriosclerosis coronary artery | 17.58 | 10.58 | 9 | 111532 | 10596 | 29452390 |
Somnolence | 17.55 | 10.58 | 249 | 111292 | 93706 | 29369280 |
Deep vein thrombosis | 17.47 | 10.58 | 309 | 111232 | 57090 | 29405896 |
Injection site haemorrhage | 17.41 | 10.58 | 5 | 111536 | 8381 | 29454605 |
Myopathy | 17.37 | 10.58 | 9 | 111532 | 10524 | 29452462 |
Heart rate decreased | 17.36 | 10.58 | 43 | 111498 | 24869 | 29438117 |
Perihepatic abscess | 17.29 | 10.58 | 8 | 111533 | 86 | 29462900 |
Fixed eruption | 17.29 | 10.58 | 22 | 111519 | 1180 | 29461806 |
Abdominal distension | 17.28 | 10.58 | 256 | 111285 | 45655 | 29417331 |
Congenital aortic stenosis | 17.13 | 10.58 | 8 | 111533 | 88 | 29462898 |
Palmar erythema | 17.09 | 10.58 | 11 | 111530 | 236 | 29462750 |
Taste disorder | 17.06 | 10.58 | 48 | 111493 | 4728 | 29458258 |
Obesity | 16.91 | 10.58 | 8 | 111533 | 9855 | 29453131 |
Lactic acidosis | 16.86 | 10.58 | 58 | 111483 | 30189 | 29432797 |
Hypoglycaemia | 16.77 | 10.58 | 110 | 111431 | 48236 | 29414750 |
Meconium abnormal | 16.71 | 10.58 | 7 | 111534 | 58 | 29462928 |
Walking aid user | 16.63 | 10.58 | 24 | 111517 | 1453 | 29461533 |
Electrocardiogram QT shortened | 16.52 | 10.58 | 9 | 111532 | 140 | 29462846 |
Osteonecrosis | 16.45 | 10.58 | 16 | 111525 | 13503 | 29449483 |
Incarcerated umbilical hernia | 16.30 | 10.58 | 5 | 111536 | 14 | 29462972 |
Univentricular heart | 16.25 | 10.58 | 6 | 111535 | 34 | 29462952 |
Neutropenic colitis | 16.12 | 10.58 | 31 | 111510 | 2380 | 29460606 |
Pulmonary oedema neonatal | 16.11 | 10.58 | 4 | 111537 | 3 | 29462983 |
Product dose omission issue | 16.09 | 10.58 | 261 | 111280 | 96122 | 29366864 |
Tendonitis | 16.07 | 10.58 | 5 | 111536 | 7956 | 29455030 |
Drug ineffective for unapproved indication | 15.97 | 10.58 | 18 | 111523 | 14196 | 29448790 |
International normalised ratio increased | 15.88 | 10.58 | 100 | 111441 | 44272 | 29418714 |
Extravasation | 15.74 | 10.58 | 25 | 111516 | 1647 | 29461339 |
Hyperaemia | 15.74 | 10.58 | 19 | 111522 | 965 | 29462021 |
Urethral valves | 15.73 | 10.58 | 11 | 111530 | 272 | 29462714 |
Bradycardia | 15.64 | 10.58 | 165 | 111376 | 65464 | 29397522 |
Liver disorder | 15.61 | 10.58 | 53 | 111488 | 27696 | 29435290 |
Ageusia | 15.60 | 10.58 | 71 | 111470 | 8867 | 29454119 |
Right ventricle outflow tract obstruction | 15.58 | 10.58 | 4 | 111537 | 4 | 29462982 |
Ventricular hypoplasia | 15.57 | 10.58 | 7 | 111534 | 70 | 29462916 |
Stoma site pain | 15.50 | 10.58 | 14 | 111527 | 505 | 29462481 |
Schizophrenia | 15.43 | 10.58 | 3 | 111538 | 6562 | 29456424 |
Rash | 15.42 | 10.58 | 869 | 110672 | 188950 | 29274036 |
Velopharyngeal incompetence | 15.36 | 10.58 | 5 | 111536 | 18 | 29462968 |
Back pain | 15.25 | 10.58 | 499 | 111042 | 101785 | 29361201 |
Anomalous pulmonary venous connection | 15.23 | 10.58 | 7 | 111534 | 74 | 29462912 |
Road traffic accident | 15.11 | 10.58 | 22 | 111519 | 15539 | 29447447 |
Dysgeusia | 15.04 | 10.58 | 141 | 111400 | 22533 | 29440453 |
Pain in extremity | 15.00 | 10.58 | 310 | 111231 | 110123 | 29352863 |
Right atrial enlargement | 14.97 | 10.58 | 10 | 111531 | 229 | 29462757 |
Depressed level of consciousness | 14.96 | 10.58 | 80 | 111461 | 36862 | 29426124 |
Electrocardiogram ST segment elevation | 14.94 | 10.58 | 44 | 111497 | 4448 | 29458538 |
Haemorrhage | 14.91 | 10.58 | 104 | 111437 | 44968 | 29418018 |
Product substitution issue | 14.88 | 10.58 | 8 | 111533 | 9164 | 29453822 |
Mental status changes | 14.85 | 10.58 | 199 | 111342 | 34728 | 29428258 |
Hyperkalaemia | 14.77 | 10.58 | 154 | 111387 | 61238 | 29401748 |
Hypervolaemia | 14.74 | 10.58 | 115 | 111426 | 17430 | 29445556 |
Catheter site pain | 14.72 | 10.58 | 20 | 111521 | 1144 | 29461842 |
Coronary artery stenosis | 14.63 | 10.58 | 7 | 111534 | 8566 | 29454420 |
Myoclonus | 14.56 | 10.58 | 93 | 111448 | 13216 | 29449770 |
Atrioventricular block complete | 14.52 | 10.58 | 6 | 111535 | 8005 | 29454981 |
Aorta hypoplasia | 14.45 | 10.58 | 7 | 111534 | 84 | 29462902 |
Poisoning | 14.42 | 10.58 | 10 | 111531 | 9983 | 29453003 |
C-reactive protein increased | 14.22 | 10.58 | 103 | 111438 | 44160 | 29418826 |
Eosinophil count increased | 14.22 | 10.58 | 5 | 111536 | 7364 | 29455622 |
Glycosylated haemoglobin increased | 14.19 | 10.58 | 9 | 111532 | 9417 | 29453569 |
Incorrect dose administered | 14.16 | 10.58 | 70 | 111471 | 32914 | 29430072 |
Product administration error | 14.12 | 10.58 | 20 | 111521 | 14290 | 29448696 |
Tympanic membrane perforation | 14.10 | 10.58 | 10 | 111531 | 253 | 29462733 |
Osteoporosis | 13.99 | 10.58 | 12 | 111529 | 10757 | 29452229 |
Injury | 13.94 | 10.58 | 121 | 111420 | 18925 | 29444061 |
Cardiac arrest | 13.93 | 10.58 | 422 | 111119 | 85169 | 29377817 |
Faeces discoloured | 13.84 | 10.58 | 18 | 111523 | 13333 | 29449653 |
Tachypnoea | 13.78 | 10.58 | 101 | 111440 | 15014 | 29447972 |
Dyslipidaemia | 13.77 | 10.58 | 3 | 111538 | 6058 | 29456928 |
Cardiac malposition | 13.75 | 10.58 | 3 | 111538 | 0 | 29462986 |
Cardiomyopathy neonatal | 13.75 | 10.58 | 3 | 111538 | 0 | 29462986 |
Hemiplegic migraine | 13.75 | 10.58 | 3 | 111538 | 0 | 29462986 |
Adenoiditis | 13.75 | 10.58 | 3 | 111538 | 0 | 29462986 |
Joint range of motion decreased | 13.75 | 10.58 | 3 | 111538 | 6051 | 29456935 |
Embolism | 13.74 | 10.58 | 57 | 111484 | 6839 | 29456147 |
Tuberculosis | 13.68 | 10.58 | 5 | 111536 | 7191 | 29455795 |
Subileus | 13.66 | 10.58 | 32 | 111509 | 2818 | 29460168 |
Large intestine anastomosis | 13.52 | 10.58 | 6 | 111535 | 58 | 29462928 |
Cyanosis neonatal | 13.51 | 10.58 | 10 | 111531 | 271 | 29462715 |
Epilepsy | 13.49 | 10.58 | 31 | 111510 | 18401 | 29444585 |
Hypophagia | 13.45 | 10.58 | 129 | 111412 | 20743 | 29442243 |
Obstructive airways disorder | 13.45 | 10.58 | 13 | 111528 | 11003 | 29451983 |
Hot flush | 13.35 | 10.58 | 99 | 111442 | 14771 | 29448215 |
Sinus tachycardia | 13.35 | 10.58 | 100 | 111441 | 14969 | 29448017 |
Pulmonary valve incompetence | 13.23 | 10.58 | 15 | 111526 | 712 | 29462274 |
Oesophageal irritation | 13.17 | 10.58 | 6 | 111535 | 62 | 29462924 |
Laryngospasm | 13.14 | 10.58 | 20 | 111521 | 1270 | 29461716 |
Gait disturbance | 13.13 | 10.58 | 196 | 111345 | 73153 | 29389833 |
Anger | 13.12 | 10.58 | 13 | 111528 | 10877 | 29452109 |
Exposure during pregnancy | 13.11 | 10.58 | 8 | 111533 | 8546 | 29454440 |
Oedema peripheral | 13.11 | 10.58 | 294 | 111247 | 103263 | 29359723 |
Seminoma | 13.10 | 10.58 | 9 | 111532 | 216 | 29462770 |
Cardiogenic shock | 13.06 | 10.58 | 120 | 111421 | 19070 | 29443916 |
Device malfunction | 12.98 | 10.58 | 8 | 111533 | 8499 | 29454487 |
Neutropenic infection | 12.94 | 10.58 | 20 | 111521 | 1287 | 29461699 |
Unresponsive to stimuli | 12.76 | 10.58 | 148 | 111393 | 24978 | 29438008 |
Pseudomonal bacteraemia | 12.75 | 10.58 | 17 | 111524 | 955 | 29462031 |
Patent ductus arteriosus | 12.72 | 10.58 | 33 | 111508 | 3098 | 29459888 |
Nephrotic syndrome | 12.72 | 10.58 | 4 | 111537 | 6324 | 29456662 |
Otorrhoea | 12.68 | 10.58 | 12 | 111529 | 460 | 29462526 |
Urine sodium decreased | 12.66 | 10.58 | 8 | 111533 | 166 | 29462820 |
Cardiac murmur | 12.66 | 10.58 | 54 | 111487 | 6559 | 29456427 |
Arthritis | 12.61 | 10.58 | 50 | 111491 | 24969 | 29438017 |
Visual acuity reduced | 12.60 | 10.58 | 23 | 111518 | 14853 | 29448133 |
Septic shock | 12.59 | 10.58 | 317 | 111224 | 62243 | 29400743 |
Depressed mood | 12.58 | 10.58 | 27 | 111514 | 16421 | 29446565 |
Therapeutic product effect prolonged | 12.54 | 10.58 | 9 | 111532 | 232 | 29462754 |
Palmar-plantar erythrodysaesthesia syndrome | 12.54 | 10.58 | 97 | 111444 | 14662 | 29448324 |
Photosensitivity reaction | 12.42 | 10.58 | 10 | 111531 | 9248 | 29453738 |
Cataract | 12.41 | 10.58 | 43 | 111498 | 22335 | 29440651 |
Viral rash | 12.39 | 10.58 | 6 | 111535 | 72 | 29462914 |
Neonatal tachycardia | 12.37 | 10.58 | 4 | 111537 | 14 | 29462972 |
Chronic obstructive pulmonary disease | 12.35 | 10.58 | 97 | 111444 | 40858 | 29422128 |
Malnutrition | 12.30 | 10.58 | 77 | 111464 | 10864 | 29452122 |
Cardiac ventricular disorder | 12.28 | 10.58 | 9 | 111532 | 240 | 29462746 |
Anaesthetic complication neurological | 12.22 | 10.58 | 10 | 111531 | 315 | 29462671 |
Locked-in syndrome | 12.22 | 10.58 | 9 | 111532 | 242 | 29462744 |
Phimosis | 12.21 | 10.58 | 14 | 111527 | 673 | 29462313 |
Medical device site fistula | 12.19 | 10.58 | 5 | 111536 | 39 | 29462947 |
Respiratory arrest | 12.17 | 10.58 | 53 | 111488 | 25780 | 29437206 |
Ventricular septal defect | 12.15 | 10.58 | 35 | 111506 | 3494 | 29459492 |
Hepatocellular injury | 12.10 | 10.58 | 128 | 111413 | 21115 | 29441871 |
Hyperlipidaemia | 12.03 | 10.58 | 18 | 111523 | 12572 | 29450414 |
Congenital hypothyroidism | 11.96 | 10.58 | 4 | 111537 | 16 | 29462970 |
Pharyngitis streptococcal | 11.96 | 10.58 | 25 | 111516 | 2039 | 29460947 |
Benign prostatic hyperplasia | 11.92 | 10.58 | 16 | 111525 | 11694 | 29451292 |
Pathogen resistance | 11.88 | 10.58 | 8 | 111533 | 8108 | 29454878 |
Fracture | 11.86 | 10.58 | 4 | 111537 | 6049 | 29456937 |
Dementia | 11.80 | 10.58 | 16 | 111525 | 11642 | 29451344 |
Oral candidiasis | 11.77 | 10.58 | 75 | 111466 | 10647 | 29452339 |
Trismus | 11.77 | 10.58 | 27 | 111514 | 2346 | 29460640 |
Enterocolitis infectious | 11.76 | 10.58 | 19 | 111522 | 1270 | 29461716 |
Muscle rigidity | 11.71 | 10.58 | 68 | 111473 | 9343 | 29453643 |
Upper airway obstruction | 11.71 | 10.58 | 13 | 111528 | 603 | 29462383 |
Cytokine storm | 11.69 | 10.58 | 13 | 111528 | 604 | 29462382 |
Injection site reaction | 11.69 | 10.58 | 15 | 111526 | 11173 | 29451813 |
Urinary tract infection neonatal | 11.68 | 10.58 | 3 | 111538 | 3 | 29462983 |
Granulocytopenia | 11.68 | 10.58 | 4 | 111537 | 5990 | 29456996 |
Chest injury | 11.58 | 10.58 | 20 | 111521 | 1413 | 29461573 |
Hyperhidrosis | 11.53 | 10.58 | 322 | 111219 | 64218 | 29398768 |
Kidney transplant rejection | 11.53 | 10.58 | 6 | 111535 | 6999 | 29455987 |
Abdominal compartment syndrome | 11.51 | 10.58 | 15 | 111526 | 824 | 29462162 |
Cytopenia | 11.47 | 10.58 | 70 | 111471 | 9789 | 29453197 |
Diaphragmatic rupture | 11.41 | 10.58 | 4 | 111537 | 19 | 29462967 |
Red blood cell sedimentation rate increased | 11.40 | 10.58 | 7 | 111534 | 7454 | 29455532 |
Therapy interrupted | 11.36 | 10.58 | 62 | 111479 | 8324 | 29454662 |
Hyperbilirubinaemia neonatal | 11.34 | 10.58 | 14 | 111527 | 728 | 29462258 |
Underdose | 11.31 | 10.58 | 17 | 111524 | 11852 | 29451134 |
Otitis media | 11.26 | 10.58 | 28 | 111513 | 2561 | 29460425 |
Necrotising enterocolitis neonatal | 11.26 | 10.58 | 8 | 111533 | 203 | 29462783 |
Antithrombin III deficiency | 11.21 | 10.58 | 6 | 111535 | 90 | 29462896 |
Pulmonary sepsis | 11.21 | 10.58 | 23 | 111518 | 1851 | 29461135 |
Nasopharyngitis | 11.18 | 10.58 | 158 | 111383 | 59507 | 29403479 |
Paraesthesia | 11.17 | 10.58 | 274 | 111267 | 53571 | 29409415 |
Tardive dyskinesia | 11.17 | 10.58 | 3 | 111538 | 5255 | 29457731 |
Sexual dysfunction | 11.12 | 10.58 | 4 | 111537 | 5810 | 29457176 |
Knee arthroplasty | 11.11 | 10.58 | 4 | 111537 | 5805 | 29457181 |
Transplant rejection | 11.10 | 10.58 | 11 | 111530 | 9201 | 29453785 |
Conductive deafness | 11.09 | 10.58 | 7 | 111534 | 145 | 29462841 |
Anaphylactoid shock | 11.09 | 10.58 | 10 | 111531 | 360 | 29462626 |
Large intestinal obstruction | 11.07 | 10.58 | 19 | 111522 | 1335 | 29461651 |
Hypophosphataemia | 11.02 | 10.58 | 59 | 111482 | 7865 | 29455121 |
Immune reconstitution inflammatory syndrome | 11.01 | 10.58 | 8 | 111533 | 7794 | 29455192 |
Infusion site urticaria | 10.98 | 10.58 | 6 | 111535 | 94 | 29462892 |
Respiratory rate increased | 10.95 | 10.58 | 10 | 111531 | 8698 | 29454288 |
Mobility decreased | 10.90 | 10.58 | 55 | 111486 | 25725 | 29437261 |
Acute sinusitis | 10.90 | 10.58 | 18 | 111523 | 1226 | 29461760 |
Parkinsonism | 10.89 | 10.58 | 7 | 111534 | 7271 | 29455715 |
Poisoning deliberate | 10.87 | 10.58 | 4 | 111537 | 5727 | 29457259 |
Glomerular filtration rate decreased | 10.87 | 10.58 | 16 | 111525 | 11250 | 29451736 |
Drug eruption | 10.82 | 10.58 | 30 | 111511 | 16711 | 29446275 |
Spinal cord injury thoracic | 10.81 | 10.58 | 6 | 111535 | 97 | 29462889 |
Thrombosis | 10.80 | 10.58 | 225 | 111316 | 42820 | 29420166 |
Right atrial dilatation | 10.77 | 10.58 | 9 | 111532 | 292 | 29462694 |
Speech sound disorder | 10.72 | 10.58 | 7 | 111534 | 154 | 29462832 |
Epistaxis | 10.70 | 10.58 | 263 | 111278 | 51441 | 29411545 |
Micrognathia | 10.59 | 10.58 | 9 | 111532 | 299 | 29462687 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1377.30 | 9.91 | 2521 | 243250 | 185136 | 64067825 |
Drug ineffective | 810.76 | 9.91 | 1222 | 244549 | 839025 | 63413936 |
Vomiting | 764.91 | 9.91 | 4120 | 241651 | 546997 | 63705964 |
Nausea | 645.04 | 9.91 | 5147 | 240624 | 780653 | 63472308 |
Drug abuse | 393.04 | 9.91 | 29 | 245742 | 132345 | 64120616 |
Neutropenia | 361.30 | 9.91 | 1836 | 243935 | 237788 | 64015173 |
Constipation | 342.09 | 9.91 | 1752 | 244019 | 227585 | 64025376 |
Diarrhoea | 338.66 | 9.91 | 4218 | 241553 | 718486 | 63534475 |
Toxicity to various agents | 324.88 | 9.91 | 554 | 245217 | 362959 | 63890002 |
Synovitis | 324.47 | 9.91 | 12 | 245759 | 99078 | 64153883 |
Serotonin syndrome | 318.39 | 9.91 | 552 | 245219 | 38730 | 64214231 |
Completed suicide | 313.51 | 9.91 | 238 | 245533 | 224176 | 64028785 |
Joint swelling | 300.12 | 9.91 | 229 | 245542 | 215153 | 64037808 |
Dehydration | 293.80 | 9.91 | 1613 | 244158 | 215150 | 64037811 |
Abdominal pain | 286.52 | 9.91 | 2104 | 243667 | 310271 | 63942690 |
Thrombocytopenia | 269.64 | 9.91 | 1614 | 244157 | 222187 | 64030774 |
Rheumatoid arthritis | 269.42 | 9.91 | 145 | 245626 | 164149 | 64088812 |
Torsade de pointes | 261.80 | 9.91 | 327 | 245444 | 17036 | 64235925 |
Disease progression | 235.69 | 9.91 | 1117 | 244654 | 140563 | 64112398 |
Arthropathy | 224.21 | 9.91 | 90 | 245681 | 120877 | 64132084 |
Therapeutic product effect decreased | 223.51 | 9.91 | 80 | 245691 | 115271 | 64137690 |
Electrocardiogram QT prolonged | 220.96 | 9.91 | 736 | 245035 | 78712 | 64174249 |
Treatment failure | 214.74 | 9.91 | 88 | 245683 | 116728 | 64136233 |
Contraindicated product administered | 213.72 | 9.91 | 72 | 245699 | 107757 | 64145204 |
Drug intolerance | 212.18 | 9.91 | 242 | 245529 | 187750 | 64065211 |
Pyrexia | 212.14 | 9.91 | 3142 | 242629 | 555502 | 63697459 |
Hand deformity | 211.19 | 9.91 | 6 | 245765 | 62765 | 64190196 |
Febrile bone marrow aplasia | 211.11 | 9.91 | 237 | 245534 | 11018 | 64241943 |
Arthralgia | 207.74 | 9.91 | 923 | 244848 | 441337 | 63811624 |
Flushing | 198.98 | 9.91 | 706 | 245065 | 77942 | 64175019 |
Mucosal inflammation | 198.85 | 9.91 | 607 | 245164 | 61977 | 64190984 |
Erythema | 196.49 | 9.91 | 1303 | 244468 | 185767 | 64067194 |
Cytokine release syndrome | 191.84 | 9.91 | 310 | 245461 | 20519 | 64232442 |
Hypoxia | 178.36 | 9.91 | 737 | 245034 | 87412 | 64165549 |
Systemic lupus erythematosus | 177.86 | 9.91 | 39 | 245732 | 77573 | 64175388 |
Plasma cell myeloma | 177.52 | 9.91 | 479 | 245292 | 45596 | 64207365 |
White blood cell count decreased | 166.67 | 9.91 | 1101 | 244670 | 156736 | 64096225 |
Sepsis | 164.96 | 9.91 | 1467 | 244304 | 228874 | 64024087 |
Aplastic anaemia | 161.99 | 9.91 | 231 | 245540 | 13689 | 64239272 |
Encephalopathy | 158.30 | 9.91 | 539 | 245232 | 58280 | 64194681 |
Overdose | 149.91 | 9.91 | 235 | 245536 | 159331 | 64093630 |
Fatigue | 149.60 | 9.91 | 3819 | 241952 | 744911 | 63508050 |
Chills | 147.63 | 9.91 | 962 | 244809 | 136302 | 64116659 |
Musculoskeletal stiffness | 147.40 | 9.91 | 151 | 245620 | 123055 | 64129906 |
Myocardial infarction | 144.85 | 9.91 | 256 | 245515 | 165565 | 64087396 |
Neuropathy peripheral | 137.76 | 9.91 | 842 | 244929 | 116683 | 64136278 |
Small intestinal obstruction | 136.29 | 9.91 | 287 | 245484 | 23286 | 64229675 |
Intentional overdose | 135.22 | 9.91 | 88 | 245683 | 89856 | 64163105 |
Therapeutic product effect incomplete | 134.11 | 9.91 | 118 | 245653 | 103364 | 64149597 |
Decreased appetite | 132.60 | 9.91 | 1646 | 244125 | 279643 | 63973318 |
Neutrophil count decreased | 121.33 | 9.91 | 599 | 245172 | 76597 | 64176364 |
Condition aggravated | 121.12 | 9.91 | 876 | 244895 | 371550 | 63881411 |
Wound | 118.85 | 9.91 | 72 | 245699 | 76405 | 64176556 |
Death | 117.88 | 9.91 | 2533 | 243238 | 480172 | 63772789 |
Pericarditis | 116.64 | 9.91 | 46 | 245725 | 62470 | 64190491 |
Colitis | 112.75 | 9.91 | 483 | 245288 | 58191 | 64194770 |
Hospice care | 112.38 | 9.91 | 142 | 245629 | 7483 | 64245478 |
Swelling | 110.92 | 9.91 | 282 | 245489 | 159936 | 64093025 |
Coronary artery disease | 108.66 | 9.91 | 47 | 245724 | 60386 | 64192575 |
Tachycardia | 107.66 | 9.91 | 954 | 244817 | 148625 | 64104336 |
Helicobacter infection | 106.76 | 9.91 | 11 | 245760 | 38351 | 64214610 |
Weight increased | 104.98 | 9.91 | 437 | 245334 | 212911 | 64040050 |
Rhabdomyolysis | 103.50 | 9.91 | 118 | 245653 | 91608 | 64161353 |
Drug hypersensitivity | 101.62 | 9.91 | 513 | 245258 | 237302 | 64015659 |
Duodenal ulcer perforation | 101.55 | 9.91 | 8 | 245763 | 34617 | 64218344 |
Neutropenic sepsis | 98.88 | 9.91 | 251 | 245520 | 23021 | 64229940 |
Suicide attempt | 98.14 | 9.91 | 76 | 245695 | 70931 | 64182030 |
Nasopharyngitis | 98.09 | 9.91 | 399 | 245372 | 195674 | 64057287 |
Ventricular tachycardia | 95.71 | 9.91 | 318 | 245453 | 33947 | 64219014 |
Glossodynia | 94.94 | 9.91 | 65 | 245706 | 64631 | 64188330 |
Impaired healing | 93.87 | 9.91 | 57 | 245714 | 60416 | 64192545 |
Ventricular fibrillation | 92.84 | 9.91 | 249 | 245522 | 23611 | 64229350 |
Injection site pain | 91.93 | 9.91 | 178 | 245593 | 111230 | 64141731 |
Asthma | 90.58 | 9.91 | 139 | 245632 | 95086 | 64157875 |
Drug resistance | 90.48 | 9.91 | 13 | 245758 | 35089 | 64217872 |
Intentional self-injury | 90.21 | 9.91 | 5 | 245766 | 29039 | 64223922 |
Blood cholesterol increased | 89.91 | 9.91 | 39 | 245732 | 50027 | 64202934 |
Hepatic enzyme increased | 89.70 | 9.91 | 229 | 245542 | 129714 | 64123247 |
Pancytopenia | 87.65 | 9.91 | 883 | 244888 | 142426 | 64110535 |
Mobility decreased | 85.85 | 9.91 | 121 | 245650 | 85719 | 64167242 |
Sleep disorder due to general medical condition, insomnia type | 83.24 | 9.91 | 4 | 245767 | 26266 | 64226695 |
Neoplasm progression | 83.20 | 9.91 | 343 | 245428 | 40621 | 64212340 |
Aplasia | 80.33 | 9.91 | 115 | 245656 | 6838 | 64246123 |
Hepatic function abnormal | 78.98 | 9.91 | 77 | 245694 | 64236 | 64188725 |
Muscle injury | 77.83 | 9.91 | 6 | 245765 | 26431 | 64226530 |
Appendicolith | 77.26 | 9.91 | 80 | 245691 | 3389 | 64249572 |
Platelet count decreased | 77.02 | 9.91 | 977 | 244794 | 166734 | 64086227 |
C-reactive protein abnormal | 76.66 | 9.91 | 10 | 245761 | 29037 | 64223924 |
Sopor | 76.42 | 9.91 | 11 | 245760 | 29650 | 64223311 |
Anaphylactic reaction | 75.45 | 9.91 | 484 | 245287 | 68180 | 64184781 |
Asthenia | 74.97 | 9.91 | 2148 | 243623 | 425896 | 63827065 |
Feeling hot | 73.64 | 9.91 | 357 | 245414 | 45306 | 64207655 |
Fall | 73.00 | 9.91 | 1133 | 244638 | 415693 | 63837268 |
Therapeutic response decreased | 69.44 | 9.91 | 58 | 245713 | 52130 | 64200831 |
Failure to thrive | 68.86 | 9.91 | 134 | 245637 | 10270 | 64242691 |
Oxygen saturation decreased | 68.73 | 9.91 | 667 | 245104 | 106509 | 64146452 |
Anaemia | 68.42 | 9.91 | 1908 | 243863 | 376772 | 63876189 |
Full blood count decreased | 67.96 | 9.91 | 215 | 245556 | 22367 | 64230594 |
Ventricular tachyarrhythmia | 66.76 | 9.91 | 28 | 245743 | 230 | 64252731 |
Intentional product misuse | 65.47 | 9.91 | 109 | 245662 | 72186 | 64180775 |
Malignant neoplasm progression | 65.44 | 9.91 | 688 | 245083 | 112183 | 64140778 |
Laryngospasm | 65.39 | 9.91 | 73 | 245698 | 3372 | 64249589 |
Osteoporosis | 64.84 | 9.91 | 40 | 245731 | 42040 | 64210921 |
Hypokalaemia | 64.21 | 9.91 | 729 | 245042 | 121174 | 64131787 |
Dysgeusia | 64.16 | 9.91 | 351 | 245420 | 46696 | 64206265 |
Injection site swelling | 64.15 | 9.91 | 39 | 245732 | 41314 | 64211647 |
Clonus | 63.81 | 9.91 | 96 | 245675 | 5971 | 64246990 |
Type 2 diabetes mellitus | 63.51 | 9.91 | 25 | 245746 | 33995 | 64218966 |
Hypotension | 63.44 | 9.91 | 1900 | 243871 | 379074 | 63873887 |
Red blood cell sedimentation rate increased | 63.37 | 9.91 | 20 | 245751 | 31215 | 64221746 |
Leukopenia | 62.93 | 9.91 | 626 | 245145 | 100616 | 64152345 |
Clostridium difficile infection | 62.89 | 9.91 | 289 | 245482 | 35874 | 64217087 |
Pneumonia | 59.52 | 9.91 | 2653 | 243118 | 556923 | 63696038 |
Ascites | 57.97 | 9.91 | 420 | 245351 | 61581 | 64191380 |
Renal impairment | 57.19 | 9.91 | 292 | 245479 | 134725 | 64118236 |
Injection site erythema | 56.77 | 9.91 | 115 | 245656 | 70685 | 64182276 |
Long QT syndrome | 56.46 | 9.91 | 83 | 245688 | 5056 | 64247905 |
Loss of personal independence in daily activities | 55.32 | 9.91 | 121 | 245650 | 72333 | 64180628 |
Osteoarthritis | 55.06 | 9.91 | 98 | 245673 | 63238 | 64189723 |
Diabetes mellitus | 55.00 | 9.91 | 106 | 245665 | 66368 | 64186593 |
Cardiac arrest | 54.42 | 9.91 | 857 | 244914 | 153207 | 64099754 |
Palmar-plantar erythrodysaesthesia syndrome | 54.40 | 9.91 | 236 | 245535 | 28583 | 64224378 |
Lactic acidosis | 54.31 | 9.91 | 94 | 245677 | 61316 | 64191645 |
Bacteraemia | 53.60 | 9.91 | 224 | 245547 | 26687 | 64226274 |
Inflammation | 53.27 | 9.91 | 105 | 245666 | 65195 | 64187766 |
Interstitial lung disease | 52.61 | 9.91 | 193 | 245578 | 97539 | 64155422 |
Psoriasis | 52.10 | 9.91 | 123 | 245648 | 71580 | 64181381 |
Impaired gastric emptying | 51.83 | 9.91 | 108 | 245663 | 8696 | 64244265 |
Carbohydrate antigen 125 increased | 51.33 | 9.91 | 49 | 245722 | 1879 | 64251082 |
Irritable bowel syndrome | 50.37 | 9.91 | 41 | 245730 | 37328 | 64215633 |
Oculogyric crisis | 50.28 | 9.91 | 55 | 245716 | 2483 | 64250478 |
Knee arthroplasty | 50.14 | 9.91 | 20 | 245751 | 26979 | 64225982 |
Pleural effusion | 50.13 | 9.91 | 718 | 245053 | 125841 | 64127120 |
Arthritis | 49.53 | 9.91 | 159 | 245612 | 83655 | 64169306 |
Oral pain | 49.51 | 9.91 | 222 | 245549 | 27271 | 64225690 |
Drug dependence | 49.50 | 9.91 | 33 | 245738 | 33279 | 64219682 |
Discomfort | 48.80 | 9.91 | 152 | 245619 | 80726 | 64172235 |
Coma | 48.50 | 9.91 | 171 | 245600 | 87444 | 64165517 |
Injection site reaction | 48.44 | 9.91 | 64 | 245707 | 46600 | 64206361 |
Wrong technique in product usage process | 48.38 | 9.91 | 110 | 245661 | 64864 | 64188097 |
Appendicitis | 48.22 | 9.91 | 137 | 245634 | 13432 | 64239529 |
Blood pressure fluctuation | 48.09 | 9.91 | 77 | 245694 | 51794 | 64201167 |
Hypomagnesaemia | 47.75 | 9.91 | 274 | 245497 | 37102 | 64215859 |
Hereditary angioedema | 47.58 | 9.91 | 66 | 245705 | 3810 | 64249151 |
Dystonia | 47.37 | 9.91 | 169 | 245602 | 18696 | 64234265 |
Blood creatine phosphokinase increased | 47.05 | 9.91 | 95 | 245676 | 58463 | 64194498 |
Unresponsive to stimuli | 46.90 | 9.91 | 341 | 245430 | 50052 | 64202909 |
Retching | 46.60 | 9.91 | 146 | 245625 | 15110 | 64237851 |
Psoriatic arthropathy | 46.33 | 9.91 | 58 | 245713 | 43223 | 64209738 |
Desmoplastic small round cell tumour | 45.30 | 9.91 | 15 | 245756 | 57 | 64252904 |
Atelectasis | 45.28 | 9.91 | 215 | 245556 | 27051 | 64225910 |
Dyspnoea | 44.90 | 9.91 | 3246 | 242525 | 715428 | 63537533 |
Neurotoxicity | 44.72 | 9.91 | 215 | 245556 | 27189 | 64225772 |
Hair colour changes | 43.58 | 9.91 | 62 | 245709 | 3665 | 64249296 |
Blood pressure systolic increased | 43.45 | 9.91 | 76 | 245695 | 49377 | 64203584 |
Clostridium difficile colitis | 43.29 | 9.91 | 212 | 245559 | 27011 | 64225950 |
Cerebral infarction | 42.90 | 9.91 | 56 | 245715 | 40988 | 64211973 |
Pulmonary embolism | 42.56 | 9.91 | 789 | 244982 | 145567 | 64107394 |
Back pain | 42.47 | 9.91 | 1251 | 244520 | 248920 | 64004041 |
Osteonecrosis of jaw | 41.98 | 9.91 | 54 | 245717 | 39771 | 64213190 |
Aggression | 41.58 | 9.91 | 70 | 245701 | 46162 | 64206799 |
Mental status changes | 41.36 | 9.91 | 385 | 245386 | 60777 | 64192184 |
Folliculitis | 40.54 | 9.91 | 33 | 245738 | 30044 | 64222917 |
Therapy non-responder | 39.65 | 9.91 | 124 | 245647 | 65775 | 64187186 |
Abdominal discomfort | 39.61 | 9.91 | 474 | 245297 | 181848 | 64071113 |
Neutropenic colitis | 39.24 | 9.91 | 66 | 245705 | 4515 | 64248446 |
Segmental diverticular colitis | 39.06 | 9.91 | 16 | 245755 | 123 | 64252838 |
Device expulsion | 38.69 | 9.91 | 16 | 245755 | 21120 | 64231841 |
Injection site bruising | 38.67 | 9.91 | 49 | 245722 | 36324 | 64216637 |
Hallucination, auditory | 37.82 | 9.91 | 9 | 245762 | 16930 | 64236031 |
Dry skin | 37.64 | 9.91 | 328 | 245443 | 50833 | 64202128 |
Sinusitis | 37.48 | 9.91 | 365 | 245406 | 145563 | 64107398 |
Melaena | 37.22 | 9.91 | 94 | 245677 | 53454 | 64199507 |
Pain in extremity | 37.21 | 9.91 | 875 | 244896 | 302210 | 63950751 |
Calcium ionised decreased | 37.10 | 9.91 | 24 | 245747 | 514 | 64252447 |
Hip arthroplasty | 36.21 | 9.91 | 18 | 245753 | 21333 | 64231628 |
Hypervolaemia | 36.16 | 9.91 | 260 | 245511 | 38025 | 64214936 |
Dilatation intrahepatic duct acquired | 36.07 | 9.91 | 26 | 245745 | 668 | 64252293 |
Treatment noncompliance | 35.39 | 9.91 | 70 | 245701 | 43412 | 64209549 |
Injection site pruritus | 35.21 | 9.91 | 56 | 245715 | 37770 | 64215191 |
Hypophagia | 35.19 | 9.91 | 265 | 245506 | 39322 | 64213639 |
Cardiac failure congestive | 35.07 | 9.91 | 323 | 245448 | 130257 | 64122704 |
C-reactive protein increased | 34.89 | 9.91 | 215 | 245556 | 94694 | 64158267 |
Cytomegalovirus infection | 34.69 | 9.91 | 55 | 245716 | 37144 | 64215817 |
Gait disturbance | 34.61 | 9.91 | 455 | 245316 | 171700 | 64081261 |
Osteonecrosis | 34.42 | 9.91 | 34 | 245737 | 28195 | 64224766 |
Basal cell carcinoma | 34.42 | 9.91 | 40 | 245731 | 30798 | 64222163 |
Blood pressure diastolic abnormal | 34.26 | 9.91 | 3 | 245768 | 11914 | 64241047 |
Lupus vasculitis | 34.05 | 9.91 | 22 | 245749 | 470 | 64252491 |
Labelled drug-drug interaction medication error | 33.95 | 9.91 | 21 | 245750 | 22041 | 64230920 |
Pancreatitis | 33.90 | 9.91 | 362 | 245409 | 59245 | 64193716 |
Hypoglycaemia | 33.90 | 9.91 | 202 | 245569 | 89690 | 64163271 |
Laryngeal discomfort | 33.77 | 9.91 | 22 | 245749 | 477 | 64252484 |
Poisoning | 33.42 | 9.91 | 21 | 245750 | 21858 | 64231103 |
Sense of oppression | 33.37 | 9.91 | 34 | 245737 | 1413 | 64251548 |
Fibromyalgia | 33.16 | 9.91 | 53 | 245718 | 35678 | 64217283 |
Stridor | 32.53 | 9.91 | 63 | 245708 | 4811 | 64248150 |
Intestinal obstruction | 32.31 | 9.91 | 243 | 245528 | 36043 | 64216918 |
Hot flush | 32.25 | 9.91 | 293 | 245478 | 45942 | 64207019 |
Electrocardiogram QT shortened | 32.16 | 9.91 | 16 | 245755 | 202 | 64252759 |
Paraesthesia | 32.04 | 9.91 | 704 | 245067 | 133818 | 64119143 |
Electrocardiogram QRS complex | 32.02 | 9.91 | 7 | 245764 | 0 | 64252961 |
Myalgia | 31.97 | 9.91 | 419 | 245352 | 158198 | 64094763 |
Obstructive airways disorder | 31.79 | 9.91 | 25 | 245746 | 23160 | 64229801 |
Depressed level of consciousness | 31.77 | 9.91 | 181 | 245590 | 81255 | 64171706 |
Liver disorder | 31.66 | 9.91 | 101 | 245670 | 53250 | 64199711 |
Anaphylactic shock | 31.61 | 9.91 | 211 | 245560 | 30117 | 64222844 |
Schizophrenia | 31.60 | 9.91 | 3 | 245768 | 11165 | 64241796 |
Heart rate decreased | 31.47 | 9.91 | 106 | 245665 | 54961 | 64198000 |
International normalised ratio increased | 31.40 | 9.91 | 175 | 245596 | 78992 | 64173969 |
Taste disorder | 31.36 | 9.91 | 93 | 245678 | 9340 | 64243621 |
Hyperkalaemia | 31.28 | 9.91 | 241 | 245530 | 100888 | 64152073 |
Computerised tomogram thorax abnormal | 31.15 | 9.91 | 38 | 245733 | 1931 | 64251030 |
Abortion spontaneous | 30.98 | 9.91 | 30 | 245741 | 25113 | 64227848 |
Lower respiratory tract infection | 30.92 | 9.91 | 222 | 245549 | 94392 | 64158569 |
Disease recurrence | 30.92 | 9.91 | 45 | 245726 | 31465 | 64221496 |
Pemphigoid | 30.83 | 9.91 | 6 | 245765 | 12980 | 64239981 |
Accidental exposure to product | 30.73 | 9.91 | 33 | 245738 | 26331 | 64226630 |
Ageusia | 30.72 | 9.91 | 119 | 245652 | 13694 | 64239267 |
Pedal pulse abnormal | 30.57 | 9.91 | 14 | 245757 | 145 | 64252816 |
Joint range of motion decreased | 30.34 | 9.91 | 18 | 245753 | 19325 | 64233636 |
Pharyngeal paraesthesia | 30.34 | 9.91 | 37 | 245734 | 1880 | 64251081 |
Pneumonitis | 30.12 | 9.91 | 309 | 245462 | 50056 | 64202905 |
Fracture | 30.06 | 9.91 | 17 | 245754 | 18738 | 64234223 |
Immune-mediated hepatitis | 29.98 | 9.91 | 42 | 245729 | 2447 | 64250514 |
Tumour lysis syndrome | 29.92 | 9.91 | 150 | 245621 | 19290 | 64233671 |
Injection site haemorrhage | 29.88 | 9.91 | 29 | 245742 | 24249 | 64228712 |
Drug interaction | 29.75 | 9.91 | 1104 | 244667 | 360979 | 63891982 |
Oral candidiasis | 29.54 | 9.91 | 170 | 245601 | 23042 | 64229919 |
Pain | 29.27 | 9.91 | 1769 | 244002 | 551742 | 63701219 |
Tendonitis | 28.93 | 9.91 | 21 | 245750 | 20261 | 64232700 |
Drug eruption | 28.71 | 9.91 | 59 | 245712 | 36077 | 64216884 |
Negative pressure pulmonary oedema | 28.66 | 9.91 | 15 | 245756 | 212 | 64252749 |
Hyperhidrosis | 28.57 | 9.91 | 650 | 245121 | 124270 | 64128691 |
Enteritis | 28.47 | 9.91 | 106 | 245665 | 11971 | 64240990 |
Cardiac failure | 28.41 | 9.91 | 345 | 245426 | 132028 | 64120933 |
Transmission of an infectious agent via product | 28.33 | 9.91 | 14 | 245757 | 174 | 64252787 |
Product use issue | 28.33 | 9.91 | 407 | 245364 | 151308 | 64101653 |
Hepatocellular injury | 28.24 | 9.91 | 280 | 245491 | 44955 | 64208006 |
Vasculitis | 28.15 | 9.91 | 17 | 245754 | 18078 | 64234883 |
Disability | 28.11 | 9.91 | 6 | 245765 | 12166 | 64240795 |
Arteriosclerosis coronary artery | 28.03 | 9.91 | 12 | 245759 | 15517 | 64237444 |
Left atrial hypertrophy | 28.01 | 9.91 | 10 | 245761 | 50 | 64252911 |
Opisthotonus | 27.91 | 9.91 | 22 | 245749 | 649 | 64252312 |
Burkholderia cepacia complex infection | 27.72 | 9.91 | 16 | 245755 | 277 | 64252684 |
Apnoea | 27.58 | 9.91 | 95 | 245676 | 10327 | 64242634 |
Deep vein thrombosis | 27.49 | 9.91 | 558 | 245213 | 104624 | 64148337 |
Paranoia | 27.41 | 9.91 | 14 | 245757 | 16338 | 64236623 |
Glaucoma | 27.40 | 9.91 | 14 | 245757 | 16334 | 64236627 |
Type I hypersensitivity | 27.36 | 9.91 | 49 | 245722 | 3525 | 64249436 |
Bone density decreased | 27.31 | 9.91 | 3 | 245768 | 9949 | 64243012 |
Oxygen saturation immeasurable | 27.22 | 9.91 | 9 | 245762 | 34 | 64252927 |
Sedation | 27.13 | 9.91 | 75 | 245696 | 41387 | 64211574 |
Epistaxis | 27.13 | 9.91 | 525 | 245246 | 97606 | 64155355 |
Skin ulcer | 26.98 | 9.91 | 82 | 245689 | 43892 | 64209069 |
Stomatitis | 26.87 | 9.91 | 576 | 245195 | 109029 | 64143932 |
Altered state of consciousness | 26.75 | 9.91 | 66 | 245705 | 37836 | 64215125 |
Sinus tachycardia | 26.68 | 9.91 | 212 | 245559 | 31976 | 64220985 |
Acute myocardial infarction | 26.64 | 9.91 | 156 | 245615 | 69562 | 64183399 |
Bronchospasm | 26.43 | 9.91 | 157 | 245614 | 21525 | 64231436 |
Sedation complication | 26.30 | 9.91 | 4 | 245767 | 10350 | 64242611 |
Product substitution issue | 26.12 | 9.91 | 18 | 245753 | 17843 | 64235118 |
Contusion | 26.01 | 9.91 | 293 | 245478 | 113672 | 64139289 |
Acute respiratory failure | 25.99 | 9.91 | 298 | 245473 | 49636 | 64203325 |
Cestode infection | 25.82 | 9.91 | 15 | 245756 | 263 | 64252698 |
Hyponatraemia | 25.75 | 9.91 | 744 | 245027 | 147595 | 64105366 |
Toxic erythema of chemotherapy | 25.56 | 9.91 | 14 | 245757 | 218 | 64252743 |
Platelet transfusion | 25.54 | 9.91 | 33 | 245738 | 1778 | 64251183 |
Drug clearance decreased | 25.52 | 9.91 | 40 | 245731 | 2579 | 64250382 |
Septic shock | 25.17 | 9.91 | 552 | 245219 | 104885 | 64148076 |
Substance abuse | 25.00 | 9.91 | 3 | 245768 | 9289 | 64243672 |
Pulse absent | 24.95 | 9.91 | 83 | 245688 | 8863 | 64244098 |
Blood pressure systolic abnormal | 24.89 | 9.91 | 4 | 245767 | 9938 | 64243023 |
Transplant rejection | 24.84 | 9.91 | 18 | 245753 | 17383 | 64235578 |
Gastrointestinal haemorrhage | 24.68 | 9.91 | 355 | 245416 | 131957 | 64121004 |
Coronary artery occlusion | 24.65 | 9.91 | 11 | 245760 | 13880 | 64239081 |
Venoocclusive liver disease | 24.53 | 9.91 | 89 | 245682 | 9926 | 64243035 |
Immune effector cell-associated neurotoxicity syndrome | 24.41 | 9.91 | 39 | 245732 | 2556 | 64250405 |
Hyperlipidaemia | 24.37 | 9.91 | 31 | 245740 | 22945 | 64230016 |
Therapy interrupted | 24.37 | 9.91 | 145 | 245626 | 19891 | 64233070 |
Suicidal ideation | 24.31 | 9.91 | 151 | 245620 | 66391 | 64186570 |
Malnutrition | 24.29 | 9.91 | 140 | 245631 | 18985 | 64233976 |
Bone erosion | 24.29 | 9.91 | 7 | 245764 | 11588 | 64241373 |
Oropharyngeal discomfort | 24.20 | 9.91 | 59 | 245712 | 5276 | 64247685 |
Malignant catatonia | 24.00 | 9.91 | 16 | 245755 | 361 | 64252600 |
Glycosylated haemoglobin increased | 23.62 | 9.91 | 16 | 245755 | 16003 | 64236958 |
Respiratory distress | 23.62 | 9.91 | 304 | 245467 | 52027 | 64200934 |
Premature delivery | 23.56 | 9.91 | 136 | 245635 | 18453 | 64234508 |
Ileus | 23.47 | 9.91 | 159 | 245612 | 22807 | 64230154 |
Tryptase increased | 23.31 | 9.91 | 17 | 245754 | 445 | 64252516 |
Blood pressure measurement | 23.29 | 9.91 | 16 | 245755 | 380 | 64252581 |
Amputation stump pain | 23.27 | 9.91 | 8 | 245763 | 35 | 64252926 |
Vascular access site thrombosis | 23.27 | 9.91 | 8 | 245763 | 35 | 64252926 |
Chest discomfort | 23.18 | 9.91 | 593 | 245178 | 115513 | 64137448 |
Hypercholesterolaemia | 23.15 | 9.91 | 15 | 245756 | 15358 | 64237603 |
Dementia | 23.10 | 9.91 | 27 | 245744 | 20739 | 64232222 |
Anaesthetic complication neurological | 22.95 | 9.91 | 18 | 245753 | 527 | 64252434 |
Rash maculo-papular | 22.86 | 9.91 | 277 | 245494 | 46749 | 64206212 |
Bursitis | 22.78 | 9.91 | 29 | 245742 | 21456 | 64231505 |
Hospitalisation | 22.74 | 9.91 | 408 | 245363 | 74799 | 64178162 |
Electrocardiogram T wave biphasic | 22.72 | 9.91 | 12 | 245759 | 173 | 64252788 |
Haematoma | 22.54 | 9.91 | 95 | 245676 | 46155 | 64206806 |
Dyslipidaemia | 22.52 | 9.91 | 4 | 245767 | 9238 | 64243723 |
Cervix neoplasm | 22.42 | 9.91 | 12 | 245759 | 178 | 64252783 |
Erectile dysfunction | 22.41 | 9.91 | 10 | 245761 | 12617 | 64240344 |
Blood potassium decreased | 22.35 | 9.91 | 244 | 245527 | 40155 | 64212806 |
Psychotic disorder | 22.29 | 9.91 | 63 | 245708 | 34515 | 64218446 |
Toxic encephalopathy | 22.19 | 9.91 | 85 | 245686 | 9730 | 64243231 |
Muscle twitching | 22.16 | 9.91 | 136 | 245635 | 18862 | 64234099 |
Blood magnesium decreased | 21.90 | 9.91 | 108 | 245663 | 13797 | 64239164 |
Hyperaemia | 21.85 | 9.91 | 38 | 245733 | 2671 | 64250290 |
Intentional product use issue | 21.83 | 9.91 | 245 | 245526 | 95119 | 64157842 |
Bone disorder | 21.83 | 9.91 | 19 | 245752 | 16740 | 64236221 |
Infective pulmonary exacerbation of cystic fibrosis | 21.80 | 9.91 | 96 | 245675 | 11700 | 64241261 |
Periorbital cellulitis | 21.64 | 9.91 | 20 | 245751 | 736 | 64252225 |
Embolism | 21.43 | 9.91 | 98 | 245673 | 12137 | 64240824 |
Femur fracture | 21.41 | 9.91 | 63 | 245708 | 34072 | 64218889 |
Cerebrovascular accident | 21.37 | 9.91 | 382 | 245389 | 137201 | 64115760 |
Peripheral sensory neuropathy | 21.34 | 9.91 | 93 | 245678 | 11285 | 64241676 |
Herpes zoster | 21.20 | 9.91 | 196 | 245575 | 78991 | 64173970 |
Inappropriate schedule of product administration | 21.16 | 9.91 | 237 | 245534 | 92049 | 64160912 |
Anaphylactoid reaction | 21.07 | 9.91 | 52 | 245719 | 4686 | 64248275 |
Administration site oedema | 21.06 | 9.91 | 7 | 245764 | 27 | 64252934 |
Red blood cell count decreased | 20.97 | 9.91 | 279 | 245492 | 48107 | 64204854 |
Somnolence | 20.96 | 9.91 | 603 | 245168 | 203042 | 64049919 |
Streptococcal bacteraemia | 20.91 | 9.91 | 40 | 245731 | 3027 | 64249934 |
Bone pain | 20.90 | 9.91 | 275 | 245496 | 47297 | 64205664 |
Rotator cuff syndrome | 20.85 | 9.91 | 10 | 245761 | 12097 | 64240864 |
Palmar erythema | 20.82 | 9.91 | 29 | 245742 | 1681 | 64251280 |
Cytopenia | 20.80 | 9.91 | 115 | 245656 | 15356 | 64237605 |
Respiratory syncytial virus infection | 20.78 | 9.91 | 68 | 245703 | 7200 | 64245761 |
Pathogen resistance | 20.64 | 9.91 | 11 | 245760 | 12532 | 64240429 |
Large intestinal obstruction | 20.63 | 9.91 | 37 | 245734 | 2665 | 64250296 |
Granulocytopenia | 20.62 | 9.91 | 7 | 245764 | 10433 | 64242528 |
Haemorrhage | 20.56 | 9.91 | 198 | 245573 | 79153 | 64173808 |
Carpal tunnel syndrome | 20.55 | 9.91 | 18 | 245753 | 15810 | 64237151 |
Obesity | 20.53 | 9.91 | 29 | 245742 | 20533 | 64232428 |
Hyperthermia | 20.52 | 9.91 | 115 | 245656 | 15435 | 64237526 |
Blood triglycerides increased | 20.49 | 9.91 | 25 | 245746 | 18841 | 64234120 |
Depression | 20.34 | 9.91 | 537 | 245234 | 182754 | 64070207 |
Alopecia areata | 20.25 | 9.91 | 27 | 245744 | 1501 | 64251460 |
Testicular germ cell cancer metastatic | 20.05 | 9.91 | 8 | 245763 | 57 | 64252904 |
Foot deformity | 19.98 | 9.91 | 20 | 245751 | 16484 | 64236477 |
Wheezing | 19.66 | 9.91 | 204 | 245567 | 80375 | 64172586 |
Myopathy | 19.66 | 9.91 | 23 | 245748 | 17657 | 64235304 |
Procedural vomiting | 19.62 | 9.91 | 18 | 245753 | 656 | 64252305 |
Hypophosphataemia | 19.51 | 9.91 | 109 | 245662 | 14611 | 64238350 |
Diabetes mellitus inadequate control | 19.43 | 9.91 | 32 | 245739 | 21289 | 64231672 |
Cerebral microhaemorrhage | 19.39 | 9.91 | 11 | 245760 | 184 | 64252777 |
Device related infection | 19.32 | 9.91 | 190 | 245581 | 30436 | 64222525 |
Panniculitis | 19.28 | 9.91 | 5 | 245766 | 8874 | 64244087 |
Post procedural hypotension | 19.26 | 9.91 | 8 | 245763 | 64 | 64252897 |
Orthostatic hypotension | 19.26 | 9.91 | 102 | 245669 | 46636 | 64206325 |
Arteriospasm coronary | 19.24 | 9.91 | 55 | 245716 | 5410 | 64247551 |
Chest pain | 19.22 | 9.91 | 1091 | 244680 | 234889 | 64018072 |
Sleep disorder due to a general medical condition | 19.14 | 9.91 | 4 | 245767 | 8230 | 64244731 |
Poisoning deliberate | 19.11 | 9.91 | 14 | 245757 | 13444 | 64239517 |
Cognitive disorder | 19.11 | 9.91 | 127 | 245644 | 54960 | 64198001 |
Lupus-like syndrome | 18.99 | 9.91 | 5 | 245766 | 8786 | 64244175 |
Migraine | 18.94 | 9.91 | 340 | 245431 | 62337 | 64190624 |
Vein discolouration | 18.91 | 9.91 | 13 | 245758 | 309 | 64252652 |
Capillary leak syndrome | 18.89 | 9.91 | 40 | 245731 | 3257 | 64249704 |
Computerised tomogram thorax | 18.82 | 9.91 | 10 | 245761 | 146 | 64252815 |
Cerebral haemorrhage | 18.63 | 9.91 | 116 | 245655 | 50974 | 64201987 |
Chronic obstructive pulmonary disease | 18.53 | 9.91 | 177 | 245594 | 70871 | 64182090 |
Pseudomonal bacteraemia | 18.52 | 9.91 | 32 | 245739 | 2237 | 64250724 |
Shock haemorrhagic | 18.50 | 9.91 | 22 | 245749 | 16769 | 64236192 |
Stress cardiomyopathy | 18.39 | 9.91 | 77 | 245694 | 9180 | 64243781 |
Insomnia | 18.34 | 9.91 | 594 | 245177 | 197242 | 64055719 |
Magnesium deficiency | 18.30 | 9.91 | 16 | 245755 | 547 | 64252414 |
Pulmonary fibrosis | 18.12 | 9.91 | 56 | 245715 | 29822 | 64223139 |
Blood bilirubin increased | 18.03 | 9.91 | 314 | 245457 | 57239 | 64195722 |
Hypothyroidism | 17.98 | 9.91 | 86 | 245685 | 40371 | 64212590 |
Glioblastoma multiforme | 17.97 | 9.91 | 22 | 245749 | 1122 | 64251839 |
Medication error | 17.94 | 9.91 | 114 | 245657 | 49852 | 64203109 |
Madarosis | 17.91 | 9.91 | 32 | 245739 | 2298 | 64250663 |
Long QT syndrome congenital | 17.89 | 9.91 | 7 | 245764 | 47 | 64252914 |
Respiratory failure | 17.88 | 9.91 | 768 | 245003 | 160415 | 64092546 |
Chemotherapeutic drug level increased | 17.87 | 9.91 | 13 | 245758 | 339 | 64252622 |
Injection site warmth | 17.86 | 9.91 | 15 | 245756 | 13447 | 64239514 |
Klebsiella bacteraemia | 17.81 | 9.91 | 32 | 245739 | 2308 | 64250653 |
Neutropenic infection | 17.76 | 9.91 | 29 | 245742 | 1936 | 64251025 |
Oedema peripheral | 17.75 | 9.91 | 639 | 245132 | 209678 | 64043283 |
Body temperature decreased | 17.64 | 9.91 | 46 | 245725 | 25882 | 64227079 |
IIIrd nerve paresis | 17.64 | 9.91 | 10 | 245761 | 167 | 64252794 |
Plantar erythema | 17.54 | 9.91 | 12 | 245759 | 283 | 64252678 |
Nail pigmentation | 17.29 | 9.91 | 12 | 245759 | 290 | 64252671 |
Premenstrual syndrome | 17.25 | 9.91 | 15 | 245756 | 509 | 64252452 |
Osteomyelitis | 17.24 | 9.91 | 51 | 245720 | 27536 | 64225425 |
Infusion site streaking | 17.20 | 9.91 | 14 | 245757 | 433 | 64252528 |
Therapeutic product effect prolonged | 17.17 | 9.91 | 15 | 245756 | 512 | 64252449 |
Nasal congestion | 17.14 | 9.91 | 145 | 245626 | 59513 | 64193448 |
Eczema | 17.12 | 9.91 | 57 | 245714 | 29663 | 64223298 |
Metastases to meninges | 17.12 | 9.91 | 35 | 245736 | 2780 | 64250181 |
Large intestine polyp | 17.12 | 9.91 | 10 | 245761 | 10827 | 64242134 |
Abdominal distension | 17.07 | 9.91 | 483 | 245288 | 95511 | 64157450 |
Lip pruritus | 17.05 | 9.91 | 17 | 245754 | 688 | 64252273 |
Joint stiffness | 17.05 | 9.91 | 59 | 245712 | 30345 | 64222616 |
Supraventricular tachycardia | 17.05 | 9.91 | 127 | 245644 | 18780 | 64234181 |
Aphasia | 16.96 | 9.91 | 234 | 245537 | 40672 | 64212289 |
Coronary artery stenosis | 16.90 | 9.91 | 11 | 245760 | 11237 | 64241724 |
Epilepsy | 16.89 | 9.91 | 68 | 245703 | 33463 | 64219498 |
Transfusion | 16.87 | 9.91 | 122 | 245649 | 17872 | 64235089 |
Prostate cancer | 16.87 | 9.91 | 31 | 245740 | 19764 | 64233197 |
Vascular access site infection | 16.81 | 9.91 | 8 | 245763 | 91 | 64252870 |
Incorrect dose administered | 16.44 | 9.91 | 150 | 245621 | 60615 | 64192346 |
Immune reconstitution inflammatory syndrome | 16.41 | 9.91 | 14 | 245757 | 12456 | 64240505 |
Uterine perforation | 16.24 | 9.91 | 54 | 245717 | 5766 | 64247195 |
Peripheral swelling | 16.20 | 9.91 | 642 | 245129 | 208511 | 64044450 |
Feeding intolerance | 16.11 | 9.91 | 15 | 245756 | 557 | 64252404 |
Eosinophil count increased | 16.08 | 9.91 | 18 | 245753 | 14094 | 64238867 |
Hypergeusia | 16.00 | 9.91 | 5 | 245766 | 15 | 64252946 |
Blood glucose increased | 15.97 | 9.91 | 270 | 245501 | 97803 | 64155158 |
Sleep disorder | 15.89 | 9.91 | 148 | 245623 | 59561 | 64193400 |
Uveitis | 15.85 | 9.91 | 15 | 245756 | 12693 | 64240268 |
Atrial fibrillation | 15.71 | 9.91 | 800 | 244971 | 170289 | 64082672 |
Malaise | 15.69 | 9.91 | 1732 | 244039 | 394515 | 63858446 |
Congenital anomaly in offspring | 15.68 | 9.91 | 7 | 245764 | 68 | 64252893 |
Visual acuity reduced | 15.67 | 9.91 | 52 | 245719 | 27089 | 64225872 |
Hyperbilirubinaemia | 15.62 | 9.91 | 136 | 245635 | 21069 | 64231892 |
Hyperthermia malignant | 15.46 | 9.91 | 31 | 245740 | 2428 | 64250533 |
Procedural nausea | 15.45 | 9.91 | 16 | 245755 | 678 | 64252283 |
Enterocolitis infectious | 15.42 | 9.91 | 31 | 245740 | 2433 | 64250528 |
Anorectal disorder | 15.38 | 9.91 | 27 | 245744 | 1912 | 64251049 |
Tubulointerstitial nephritis | 15.37 | 9.91 | 63 | 245708 | 30846 | 64222115 |
Delirium | 15.35 | 9.91 | 179 | 245592 | 69015 | 64183946 |
Onychalgia | 15.32 | 9.91 | 17 | 245754 | 780 | 64252181 |
Neutrophil count abnormal | 15.30 | 9.91 | 34 | 245737 | 2862 | 64250099 |
Angina unstable | 15.26 | 9.91 | 22 | 245749 | 15445 | 64237516 |
Angina pectoris | 15.10 | 9.91 | 105 | 245666 | 44976 | 64207985 |
Uterine hypotonus | 14.92 | 9.91 | 7 | 245764 | 77 | 64252884 |
Nephrotic syndrome | 14.87 | 9.91 | 9 | 245762 | 9558 | 64243403 |
Musculoskeletal pain | 14.85 | 9.91 | 219 | 245552 | 81075 | 64171886 |
Posterior reversible encephalopathy syndrome | 14.79 | 9.91 | 143 | 245628 | 22803 | 64230158 |
Troponin increased | 14.78 | 9.91 | 105 | 245666 | 15294 | 64237667 |
Alopecia totalis | 14.66 | 9.91 | 11 | 245760 | 301 | 64252660 |
Myoclonus | 14.49 | 9.91 | 153 | 245618 | 24965 | 64227996 |
Joint effusion | 14.48 | 9.91 | 18 | 245753 | 13455 | 64239506 |
Tuberculosis | 14.45 | 9.91 | 17 | 245754 | 13021 | 64239940 |
Abdominal mass | 14.38 | 9.91 | 34 | 245737 | 2981 | 64249980 |
Subchorionic haemorrhage | 14.36 | 9.91 | 8 | 245763 | 129 | 64252832 |
Haemodialysis | 14.32 | 9.91 | 27 | 245744 | 17050 | 64235911 |
Eye irritation | 14.26 | 9.91 | 24 | 245747 | 15832 | 64237129 |
Lipase decreased | 14.25 | 9.91 | 8 | 245763 | 131 | 64252830 |
Extravasation | 14.24 | 9.91 | 35 | 245736 | 3145 | 64249816 |
Seminoma | 14.19 | 9.91 | 9 | 245762 | 186 | 64252775 |
Sensitivity to weather change | 14.16 | 9.91 | 4 | 245767 | 6710 | 64246251 |
Perihepatic abscess | 14.09 | 9.91 | 8 | 245763 | 134 | 64252827 |
Chronic hepatitis B | 14.04 | 9.91 | 10 | 245761 | 252 | 64252709 |
Ulcer | 14.01 | 9.91 | 43 | 245728 | 22947 | 64230014 |
Enterocolitis | 13.99 | 9.91 | 86 | 245685 | 11932 | 64241029 |
Joint injury | 13.92 | 9.91 | 43 | 245728 | 22904 | 64230057 |
Shock | 13.85 | 9.91 | 87 | 245684 | 38153 | 64214808 |
Joint dislocation | 13.76 | 9.91 | 14 | 245757 | 11451 | 64241510 |
Head and neck cancer metastatic | 13.72 | 9.91 | 3 | 245768 | 0 | 64252961 |
Foetal damage | 13.72 | 9.91 | 3 | 245768 | 0 | 64252961 |
Electrocardiogram PR shortened | 13.70 | 9.91 | 10 | 245761 | 262 | 64252699 |
Myocardial reperfusion injury | 13.69 | 9.91 | 5 | 245766 | 27 | 64252934 |
Exostosis | 13.69 | 9.91 | 14 | 245757 | 11424 | 64241537 |
Irritability | 13.62 | 9.91 | 83 | 245688 | 36663 | 64216298 |
Formication | 13.59 | 9.91 | 42 | 245729 | 4315 | 64248646 |
Abnormal behaviour | 13.51 | 9.91 | 74 | 245697 | 33548 | 64219413 |
Polymenorrhoea | 13.49 | 9.91 | 17 | 245754 | 893 | 64252068 |
Acute myeloid leukaemia | 13.45 | 9.91 | 162 | 245609 | 27301 | 64225660 |
Gastroenteropancreatic neuroendocrine tumour disease | 13.40 | 9.91 | 5 | 245766 | 29 | 64252932 |
Hair texture abnormal | 13.39 | 9.91 | 33 | 245738 | 2971 | 64249990 |
Blood pressure diastolic decreased | 13.38 | 9.91 | 42 | 245729 | 22259 | 64230702 |
Tracheal injury | 13.37 | 9.91 | 6 | 245765 | 59 | 64252902 |
Sialoadenitis | 13.29 | 9.91 | 23 | 245748 | 1610 | 64251351 |
Drug abuser | 13.14 | 9.91 | 3 | 245768 | 5805 | 64247156 |
Anger | 13.11 | 9.91 | 25 | 245746 | 15716 | 64237245 |
Postural orthostatic tachycardia syndrome | 13.10 | 9.91 | 13 | 245758 | 523 | 64252438 |
Seizure like phenomena | 13.10 | 9.91 | 23 | 245748 | 1629 | 64251332 |
Device malfunction | 13.00 | 9.91 | 30 | 245741 | 17603 | 64235358 |
Cerebellar stroke | 13.00 | 9.91 | 12 | 245759 | 441 | 64252520 |
Intestinal infarction | 12.97 | 9.91 | 20 | 245751 | 1271 | 64251690 |
Necrotising retinitis | 12.90 | 9.91 | 18 | 245753 | 1045 | 64251916 |
Pulseless electrical activity | 12.90 | 9.91 | 88 | 245683 | 12651 | 64240310 |
Cyclic vomiting syndrome | 12.87 | 9.91 | 6 | 245765 | 65 | 64252896 |
Skin cancer | 12.86 | 9.91 | 16 | 245755 | 11958 | 64241003 |
Painful respiration | 12.85 | 9.91 | 33 | 245738 | 3048 | 64249913 |
Creatinine renal clearance decreased | 12.81 | 9.91 | 22 | 245749 | 14399 | 64238562 |
Infection | 12.74 | 9.91 | 575 | 245196 | 184305 | 64068656 |
Pregnancy | 12.73 | 9.91 | 39 | 245732 | 20826 | 64232135 |
Pharyngeal hypoaesthesia | 12.69 | 9.91 | 10 | 245761 | 295 | 64252666 |
Ill-defined disorder | 12.69 | 9.91 | 107 | 245664 | 43945 | 64209016 |
Coating in mouth | 12.66 | 9.91 | 9 | 245762 | 226 | 64252735 |
Skin necrosis | 12.61 | 9.91 | 22 | 245749 | 14307 | 64238654 |
Blood alkaline phosphatase increased | 12.60 | 9.91 | 292 | 245479 | 55987 | 64196974 |
Urinary tract infection | 12.53 | 9.91 | 1035 | 244736 | 230561 | 64022400 |
Drug reaction with eosinophilia and systemic symptoms | 12.52 | 9.91 | 139 | 245632 | 54078 | 64198883 |
Unintentional medical device removal | 12.48 | 9.91 | 5 | 245766 | 6729 | 64246232 |
Gastroenteritis radiation | 12.45 | 9.91 | 14 | 245757 | 652 | 64252309 |
Electrocardiogram T wave inversion | 12.42 | 9.91 | 44 | 245727 | 4850 | 64248111 |
Benign prostatic hyperplasia | 12.42 | 9.91 | 10 | 245761 | 9155 | 64243806 |
Disseminated aspergillosis | 12.41 | 9.91 | 14 | 245757 | 654 | 64252307 |
Throat tightness | 12.40 | 9.91 | 139 | 245632 | 23021 | 64229940 |
Erythropenia | 12.38 | 9.91 | 11 | 245760 | 384 | 64252577 |
Sleep apnoea syndrome | 12.35 | 9.91 | 65 | 245706 | 29767 | 64223194 |
Suspected suicide | 12.29 | 9.91 | 9 | 245762 | 8645 | 64244316 |
Sciatica | 12.28 | 9.91 | 38 | 245733 | 20226 | 64232735 |
Feeding disorder | 12.26 | 9.91 | 88 | 245683 | 12861 | 64240100 |
Wrist fracture | 12.24 | 9.91 | 12 | 245759 | 9989 | 64242972 |
Breast cancer metastatic | 12.24 | 9.91 | 57 | 245714 | 7112 | 64245849 |
Intestinal perforation | 12.23 | 9.91 | 100 | 245671 | 15213 | 64237748 |
Cytotoxic oedema | 12.21 | 9.91 | 10 | 245761 | 312 | 64252649 |
Lymphoid tissue hypoplasia | 12.17 | 9.91 | 12 | 245759 | 479 | 64252482 |
Medical device site fistula | 12.14 | 9.91 | 5 | 245766 | 39 | 64252922 |
Kidney transplant rejection | 12.13 | 9.91 | 11 | 245760 | 9500 | 64243461 |
Tongue disorder | 12.10 | 9.91 | 17 | 245754 | 12063 | 64240898 |
Moaning | 12.03 | 9.91 | 17 | 245754 | 999 | 64251962 |
Non-cardiac chest pain | 11.99 | 9.91 | 65 | 245706 | 8615 | 64244346 |
Abdominal pain upper | 11.96 | 9.91 | 797 | 244974 | 174233 | 64078728 |
Blood pressure diastolic increased | 11.94 | 9.91 | 14 | 245757 | 10738 | 64242223 |
Skin burning sensation | 11.87 | 9.91 | 75 | 245696 | 10508 | 64242453 |
Dysphagia | 11.85 | 9.91 | 509 | 245262 | 106303 | 64146658 |
Tachypnoea | 11.84 | 9.91 | 154 | 245617 | 26417 | 64226544 |
Incarcerated umbilical hernia | 11.83 | 9.91 | 5 | 245766 | 42 | 64252919 |
Metastases to peritoneum | 11.82 | 9.91 | 35 | 245736 | 3512 | 64249449 |
Ventricular hypertrophy | 11.82 | 9.91 | 5 | 245766 | 6511 | 64246450 |
Platelet count increased | 11.80 | 9.91 | 116 | 245655 | 18580 | 64234381 |
Laryngeal dyspnoea | 11.76 | 9.91 | 9 | 245762 | 254 | 64252707 |
Abdominal infection | 11.76 | 9.91 | 31 | 245740 | 2909 | 64250052 |
Periorbital disorder | 11.63 | 9.91 | 5 | 245766 | 44 | 64252917 |
Dysphemia | 11.58 | 9.91 | 32 | 245739 | 3087 | 64249874 |
Blister | 11.58 | 9.91 | 228 | 245543 | 80739 | 64172222 |
Escherichia bacteraemia | 11.57 | 9.91 | 46 | 245725 | 5357 | 64247604 |
Appendicitis perforated | 11.55 | 9.91 | 30 | 245741 | 2790 | 64250171 |
Food intolerance | 11.51 | 9.91 | 30 | 245741 | 2796 | 64250165 |
Parainfluenzae virus infection | 11.49 | 9.91 | 42 | 245729 | 4701 | 64248260 |
Coeliac disease | 11.48 | 9.91 | 7 | 245764 | 7405 | 64245556 |
Muscle spasms | 11.47 | 9.91 | 652 | 245119 | 140371 | 64112590 |
Electrocardiogram QRS complex prolonged | 11.42 | 9.91 | 11 | 245760 | 9233 | 64243728 |
Respiratory rate increased | 11.37 | 9.91 | 34 | 245737 | 18297 | 64234664 |
Thymus hypoplasia | 11.35 | 9.91 | 12 | 245759 | 521 | 64252440 |
Gait inability | 11.28 | 9.91 | 105 | 245666 | 42263 | 64210698 |
Acute kidney injury | 11.24 | 9.91 | 1911 | 243860 | 447329 | 63805632 |
Cataract | 11.22 | 9.91 | 133 | 245638 | 51129 | 64201832 |
Sinus node dysfunction | 11.22 | 9.91 | 6 | 245765 | 6822 | 64246139 |
Influenza B virus test positive | 11.21 | 9.91 | 10 | 245761 | 351 | 64252610 |
Electrocardiogram ST segment elevation | 11.16 | 9.91 | 56 | 245715 | 7203 | 64245758 |
Ankylosing spondylitis | 11.14 | 9.91 | 9 | 245762 | 8225 | 64244736 |
Chest injury | 11.13 | 9.91 | 27 | 245744 | 2406 | 64250555 |
Asphyxia | 11.12 | 9.91 | 12 | 245759 | 9554 | 64243407 |
Muscle haemorrhage | 11.12 | 9.91 | 4 | 245767 | 5749 | 64247212 |
Intensive care | 11.11 | 9.91 | 13 | 245758 | 632 | 64252329 |
Chronic graft versus host disease | 11.09 | 9.91 | 5 | 245766 | 6271 | 64246690 |
Lung opacity | 11.08 | 9.91 | 32 | 245739 | 3167 | 64249794 |
Low density lipoprotein increased | 11.06 | 9.91 | 8 | 245763 | 7732 | 64245229 |
Choking sensation | 10.95 | 9.91 | 34 | 245737 | 3501 | 64249460 |
Arteriosclerosis | 10.93 | 9.91 | 28 | 245743 | 15849 | 64237112 |
Antipsychotic drug level increased | 10.88 | 9.91 | 3 | 245768 | 5112 | 64247849 |
Abdominal pain lower | 10.80 | 9.91 | 151 | 245620 | 26318 | 64226643 |
Catatonia | 10.72 | 9.91 | 8 | 245763 | 7612 | 64245349 |
Trismus | 10.72 | 9.91 | 42 | 245729 | 4859 | 64248102 |
Squamous cell carcinoma | 10.72 | 9.91 | 23 | 245748 | 13846 | 64239115 |
Large intestine anastomosis | 10.70 | 9.91 | 6 | 245765 | 98 | 64252863 |
Blood urea increased | 10.68 | 9.91 | 112 | 245659 | 44041 | 64208920 |
Respiratory arrest | 10.65 | 9.91 | 140 | 245631 | 52845 | 64200116 |
Left ventricular dysfunction | 10.61 | 9.91 | 105 | 245666 | 16849 | 64236112 |
Lichen sclerosus | 10.60 | 9.91 | 15 | 245756 | 882 | 64252079 |
Hyperemesis gravidarum | 10.57 | 9.91 | 10 | 245761 | 379 | 64252582 |
Cancer pain | 10.57 | 9.91 | 38 | 245733 | 4219 | 64248742 |
Thrombosis | 10.57 | 9.91 | 348 | 245423 | 70294 | 64182667 |
Tumour pain | 10.56 | 9.91 | 23 | 245748 | 1910 | 64251051 |
Cyanosis | 10.55 | 9.91 | 130 | 245641 | 22025 | 64230936 |
Neuralgia | 10.53 | 9.91 | 149 | 245622 | 26035 | 64226926 |
Transaminases increased | 10.49 | 9.91 | 233 | 245538 | 44361 | 64208600 |
Vascular device infection | 10.46 | 9.91 | 49 | 245722 | 6131 | 64246830 |
Cleft palate | 10.45 | 9.91 | 3 | 245768 | 6 | 64252955 |
Multiple fractures | 10.38 | 9.91 | 5 | 245766 | 6035 | 64246926 |
Subileus | 10.36 | 9.91 | 42 | 245729 | 4935 | 64248026 |
Carotid artery stenosis | 10.35 | 9.91 | 9 | 245762 | 7932 | 64245029 |
Muscle rigidity | 10.35 | 9.91 | 107 | 245664 | 17366 | 64235595 |
Neutrophil percentage abnormal | 10.34 | 9.91 | 4 | 245767 | 26 | 64252935 |
Menstruation delayed | 10.33 | 9.91 | 17 | 245754 | 1142 | 64251819 |
Aortic arteriosclerosis | 10.33 | 9.91 | 8 | 245763 | 7468 | 64245493 |
Eye haemorrhage | 10.27 | 9.91 | 10 | 245761 | 8350 | 64244611 |
Enterovirus test positive | 10.27 | 9.91 | 8 | 245763 | 232 | 64252729 |
Enterocutaneous fistula | 10.24 | 9.91 | 20 | 245751 | 1537 | 64251424 |
Scratch | 10.23 | 9.91 | 6 | 245765 | 6483 | 64246478 |
Drug ineffective for unapproved indication | 10.19 | 9.91 | 73 | 245698 | 31060 | 64221901 |
Gastrooesophageal reflux disease | 10.18 | 9.91 | 240 | 245531 | 82903 | 64170058 |
Sexual dysfunction | 10.18 | 9.91 | 6 | 245765 | 6465 | 64246496 |
Tardive dyskinesia | 10.14 | 9.91 | 12 | 245759 | 9166 | 64243795 |
Cholecystitis | 10.13 | 9.91 | 117 | 245654 | 19519 | 64233442 |
Intraocular pressure increased | 10.12 | 9.91 | 10 | 245761 | 8292 | 64244669 |
Nail infection | 10.11 | 9.91 | 22 | 245749 | 1825 | 64251136 |
Road traffic accident | 10.11 | 9.91 | 72 | 245699 | 30673 | 64222288 |
Hydronephrosis | 10.10 | 9.91 | 90 | 245681 | 14035 | 64238926 |
Vitamin B1 decreased | 10.09 | 9.91 | 9 | 245762 | 316 | 64252645 |
Incorrect route of product administration | 10.08 | 9.91 | 50 | 245721 | 23248 | 64229713 |
Alveolitis | 10.07 | 9.91 | 34 | 245737 | 3658 | 64249303 |
Dental caries | 10.04 | 9.91 | 16 | 245755 | 10784 | 64242177 |
Vocal cord paralysis | 10.02 | 9.91 | 24 | 245747 | 2122 | 64250839 |
Corneal bleeding | 9.97 | 9.91 | 4 | 245767 | 29 | 64252932 |
Weight decreased | 9.96 | 9.91 | 1239 | 244532 | 284500 | 63968461 |
Mucormycosis | 9.96 | 9.91 | 8 | 245763 | 7333 | 64245628 |
Product administration error | 9.96 | 9.91 | 63 | 245708 | 27580 | 64225381 |
Systemic inflammatory response syndrome | 9.95 | 9.91 | 70 | 245701 | 10165 | 64242796 |
Fixed eruption | 9.92 | 9.91 | 24 | 245747 | 2135 | 64250826 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Human herpesvirus 6 infection | 47.76 | 30.08 | 15 | 320 | 45 | 84298 |
Cardiac failure | 45.07 | 30.08 | 15 | 320 | 57 | 84286 |
Congestive cardiomyopathy | 41.29 | 30.08 | 14 | 321 | 57 | 84286 |
Multiple organ dysfunction syndrome | 38.34 | 30.08 | 15 | 320 | 99 | 84244 |
Source | Code | Description |
---|---|---|
ATC | A04AA01 | ALIMENTARY TRACT AND METABOLISM ANTIEMETICS AND ANTINAUSEANTS ANTIEMETICS AND ANTINAUSEANTS Serotonin (5HT3) antagonists |
FDA MoA | N0000175817 | Serotonin 3 Receptor Antagonists |
FDA EPC | N0000175818 | Serotonin-3 Receptor Antagonist |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D000982 | Antipruritics |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Chemotherapy-induced nausea and vomiting | indication | 236084000 | |
Prevention of Radiation-Induced Nausea and Vomiting | indication | ||
Prevention of Post-Operative Nausea and Vomiting | indication | ||
Excessive vomiting in pregnancy | off-label use | 14094001 | |
Torsades de pointes | contraindication | 31722008 | |
Hepatic failure | contraindication | 59927004 | |
Extrapyramidal disease | contraindication | 76349003 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.13 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 7.80 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.34 | DRUG MATRIX | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.68 | WOMBAT-PK | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.69 | CHEMBL | |||||
Solute carrier family 22 member 2 | Transporter | IC50 | 5.77 | CHEMBL | |||||
Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 7.52 | CHEMBL | |||||
Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 6.80 | CHEMBL | |||||
Solute carrier family 22 member 3 | Transporter | IC50 | 4.76 | CHEMBL | |||||
Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 4.34 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.09 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 3B | Ion channel | Ki | 8.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.43 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 5.54 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5 | CHEMBL | |||||
Gastrin/cholecystokinin type B receptor | GPCR | Ki | 6.17 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.17 | CHEMBL | |||||
Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | IC50 | 4.60 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 5.92 | CHEMBL | |||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 9.11 | CHEMBL | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 4.70 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 9.11 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 5 | CHEMBL | |||||
Serotonin 3 receptor (5HT3) | Ion channel | Ki | 7.92 | CHEMBL |
ID | Source |
---|---|
4019865 | VUID |
N0000147951 | NUI |
D00456 | KEGG_DRUG |
103639-04-9 | SECONDARY_CAS_RN |
4019563 | VANDF |
4019865 | VANDF |
C0061851 | UMLSCUI |
CHEBI:7773 | CHEBI |
S87 | PDB_CHEM_ID |
CHEMBL46 | ChEMBL_ID |
CHEMBL399705 | ChEMBL_ID |
CHEMBL428411 | ChEMBL_ID |
CHEMBL3186492 | ChEMBL_ID |
CHEMBL1201111 | ChEMBL_ID |
DB00904 | DRUGBANK_ID |
D017294 | MESH_DESCRIPTOR_UI |
4595 | PUBCHEM_CID |
2290 | IUPHAR_LIGAND_ID |
5965 | INN_ID |
4AF302ESOS | UNII |
203148 | RXNORM |
27290 | MMSL |
39615 | MMSL |
5202 | MMSL |
90631 | MMSL |
d00867 | MMSL |
003568 | NDDF |
004807 | NDDF |
108418007 | SNOMEDCT_US |
108419004 | SNOMEDCT_US |
372487007 | SNOMEDCT_US |
830157000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ondansetron Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0064 | SOLUTION | 4 mg | ORAL | ANDA | 27 sections |
ZOFRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0675 | TABLET, FILM COATED | 4 mg | ORAL | NDA | 31 sections |
ZOFRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0676 | TABLET, FILM COATED | 8 mg | ORAL | NDA | 31 sections |
Ondansetron Hydrochloride and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9771 | INJECTION, SOLUTION | 32 mg | INTRAVENOUS | ANDA | 24 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9890 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9891 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7732 | TABLET, ORALLY DISINTEGRATING | 4 mg | ORAL | ANDA | 28 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7734 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 28 sections |
ONDANSETRON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9930 | INJECTION | 2 mg | INTRAVENOUS | ANDA | 18 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4755 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 32 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4759 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 32 sections |
Ondansetron Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1726 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8185 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6078 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6078 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6079 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6079 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6080 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6080 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6551 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 27 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6551 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 27 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6552 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 27 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6552 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7073 | SOLUTION | 4 mg | ORAL | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7073 | SOLUTION | 4 mg | ORAL | ANDA | 27 sections |
Ondansetron Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-575 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 22 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11819-365 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11819-371 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-545 | TABLET, ORALLY DISINTEGRATING | 4 mg | ORAL | ANDA | 12 sections |
Ondansetron | Human Prescription Drug Label | 1 | 16714-159 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 27 sections |