Stem definition | Drug id | CAS RN |
---|---|---|
serotonin receptor antagonists (5-HT3) | 1992 | 99614-02-5 |
Dose | Unit | Route |
---|---|---|
16 | mg | O |
16 | mg | P |
16 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 5.70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.17 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 62 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.27 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 4, 1991 | FDA | NOVARTIS PHARMS CORP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nausea | 886.80 | 9.65 | 5449 | 192852 | 682005 | 45805756 |
Drug ineffective | 747.44 | 9.65 | 1081 | 197220 | 676757 | 45811004 |
Febrile neutropenia | 585.75 | 9.65 | 1262 | 197039 | 93365 | 46394396 |
Rheumatoid arthritis | 584.65 | 9.65 | 150 | 198151 | 240065 | 46247696 |
Vomiting | 570.90 | 9.65 | 3574 | 194727 | 449220 | 46038541 |
Dehydration | 325.30 | 9.65 | 1441 | 196860 | 158099 | 46329662 |
Constipation | 304.70 | 9.65 | 1504 | 196797 | 172593 | 46315168 |
Abdominal pain | 255.59 | 9.65 | 1762 | 196539 | 228269 | 46259492 |
Contraindicated product administered | 249.61 | 9.65 | 25 | 198276 | 79922 | 46407839 |
Joint swelling | 242.79 | 9.65 | 209 | 198092 | 165864 | 46321897 |
Diarrhoea | 242.40 | 9.65 | 3520 | 194781 | 556082 | 45931679 |
Treatment failure | 226.35 | 9.65 | 58 | 198243 | 93029 | 46394732 |
Synovitis | 220.33 | 9.65 | 9 | 198292 | 61066 | 46426695 |
Disease progression | 208.53 | 9.65 | 854 | 197447 | 90446 | 46397315 |
Completed suicide | 204.44 | 9.65 | 191 | 198110 | 145729 | 46342032 |
Toxicity to various agents | 204.20 | 9.65 | 367 | 197934 | 211399 | 46276362 |
Neutropenia | 203.11 | 9.65 | 1168 | 197133 | 142036 | 46345725 |
Drug abuse | 185.05 | 9.65 | 25 | 198276 | 63383 | 46424378 |
Drug intolerance | 181.80 | 9.65 | 214 | 198087 | 146835 | 46340926 |
Arthralgia | 178.15 | 9.65 | 870 | 197431 | 363733 | 46124028 |
Emotional distress | 175.51 | 9.65 | 397 | 197904 | 30310 | 46457451 |
Therapeutic product effect decreased | 173.13 | 9.65 | 67 | 198234 | 82534 | 46405227 |
Drug hypersensitivity | 167.23 | 9.65 | 507 | 197794 | 243318 | 46244443 |
Injury | 165.39 | 9.65 | 486 | 197815 | 43541 | 46444220 |
Arthropathy | 137.12 | 9.65 | 96 | 198205 | 84604 | 46403157 |
Mucosal inflammation | 136.72 | 9.65 | 420 | 197881 | 38556 | 46449205 |
Systemic lupus erythematosus | 134.72 | 9.65 | 54 | 198247 | 65126 | 46422635 |
Thrombocytopenia | 130.58 | 9.65 | 953 | 197348 | 125628 | 46362133 |
Hypoxia | 122.34 | 9.65 | 490 | 197811 | 51348 | 46436413 |
Intentional overdose | 119.93 | 9.65 | 63 | 198238 | 64881 | 46422880 |
Hand deformity | 118.60 | 9.65 | 7 | 198294 | 34567 | 46453194 |
Neuropathy peripheral | 118.22 | 9.65 | 725 | 197576 | 90168 | 46397593 |
Injection site pain | 114.03 | 9.65 | 174 | 198127 | 106978 | 46380783 |
Small intestinal obstruction | 113.09 | 9.65 | 227 | 198074 | 15945 | 46471816 |
Encephalopathy | 111.40 | 9.65 | 355 | 197946 | 33234 | 46454527 |
White blood cell count decreased | 111.20 | 9.65 | 837 | 197464 | 111394 | 46376367 |
Torsade de pointes | 110.55 | 9.65 | 191 | 198110 | 11963 | 46475798 |
Decreased appetite | 109.56 | 9.65 | 1282 | 197019 | 192554 | 46295207 |
Therapeutic product effect incomplete | 107.39 | 9.65 | 104 | 198197 | 78049 | 46409712 |
Overdose | 107.17 | 9.65 | 167 | 198134 | 101812 | 46385949 |
Psoriasis | 106.39 | 9.65 | 106 | 198195 | 78498 | 46409263 |
Left-to-right cardiac shunt | 103.30 | 9.65 | 33 | 198268 | 94 | 46487667 |
Heart disease congenital | 102.61 | 9.65 | 65 | 198236 | 1196 | 46486565 |
Musculoskeletal stiffness | 101.52 | 9.65 | 162 | 198139 | 97831 | 46389930 |
Febrile bone marrow aplasia | 99.59 | 9.65 | 134 | 198167 | 6728 | 46481033 |
Pyrexia | 98.11 | 9.65 | 2050 | 196251 | 346752 | 46141009 |
Erythema | 96.54 | 9.65 | 979 | 197322 | 141841 | 46345920 |
Serotonin syndrome | 96.38 | 9.65 | 273 | 198028 | 23947 | 46463814 |
Fall | 85.78 | 9.65 | 939 | 197362 | 328158 | 46159603 |
Electrocardiogram QT prolonged | 85.72 | 9.65 | 438 | 197863 | 50887 | 46436874 |
Abortion spontaneous | 84.10 | 9.65 | 40 | 198261 | 43606 | 46444155 |
Injection site erythema | 83.94 | 9.65 | 116 | 198185 | 74311 | 46413450 |
Hereditary angioedema | 83.56 | 9.65 | 110 | 198191 | 5406 | 46482355 |
Condition aggravated | 82.40 | 9.65 | 656 | 197645 | 244396 | 46243365 |
Colitis | 80.22 | 9.65 | 343 | 197958 | 37004 | 46450757 |
Fatigue | 79.80 | 9.65 | 3249 | 195052 | 605448 | 45882313 |
Flushing | 79.37 | 9.65 | 508 | 197793 | 64106 | 46423655 |
Intentional self-injury | 76.87 | 9.65 | 7 | 198294 | 24159 | 46463602 |
Injection site swelling | 76.12 | 9.65 | 38 | 198263 | 40289 | 46447472 |
Mobility decreased | 76.09 | 9.65 | 87 | 198214 | 60507 | 46427254 |
Myocardial infarction | 75.51 | 9.65 | 191 | 198110 | 97337 | 46390424 |
Asthma | 74.23 | 9.65 | 175 | 198126 | 91367 | 46396394 |
Malignant neoplasm progression | 73.41 | 9.65 | 500 | 197801 | 64426 | 46423335 |
Anhedonia | 72.18 | 9.65 | 145 | 198156 | 10190 | 46477571 |
Suicide attempt | 70.22 | 9.65 | 78 | 198223 | 54958 | 46432803 |
Neutrophil count decreased | 69.33 | 9.65 | 366 | 197935 | 43060 | 46444701 |
Injection site reaction | 68.88 | 9.65 | 61 | 198240 | 47788 | 46439973 |
C-reactive protein abnormal | 68.09 | 9.65 | 6 | 198295 | 21264 | 46466497 |
Device expulsion | 67.22 | 9.65 | 17 | 198284 | 27525 | 46460236 |
Laryngospasm | 66.24 | 9.65 | 71 | 198230 | 2802 | 46484959 |
Weight increased | 65.60 | 9.65 | 419 | 197882 | 164054 | 46323707 |
Oculogyric crisis | 63.58 | 9.65 | 48 | 198253 | 1185 | 46486576 |
Pleural effusion | 63.57 | 9.65 | 584 | 197717 | 82368 | 46405393 |
Therapeutic response decreased | 62.11 | 9.65 | 55 | 198246 | 43090 | 46444671 |
Ventricular tachycardia | 60.57 | 9.65 | 184 | 198117 | 16783 | 46470978 |
Plasma cell myeloma | 60.47 | 9.65 | 359 | 197942 | 44119 | 46443642 |
Dystonia | 58.24 | 9.65 | 140 | 198161 | 11117 | 46476644 |
Red blood cell sedimentation rate increased | 58.08 | 9.65 | 13 | 198288 | 22876 | 46464885 |
Death | 57.73 | 9.65 | 1848 | 196453 | 333700 | 46154061 |
Platelet count decreased | 57.50 | 9.65 | 664 | 197637 | 99360 | 46388401 |
Cytokine release syndrome | 56.86 | 9.65 | 98 | 198203 | 6125 | 46481636 |
Atelectasis | 55.51 | 9.65 | 191 | 198110 | 18599 | 46469162 |
Congenital anomaly | 55.35 | 9.65 | 49 | 198252 | 1523 | 46486238 |
Neutropenic sepsis | 55.10 | 9.65 | 145 | 198156 | 12179 | 46475582 |
Intestinal obstruction | 54.85 | 9.65 | 238 | 198063 | 25837 | 46461924 |
Carbohydrate antigen 125 increased | 54.59 | 9.65 | 59 | 198242 | 2351 | 46485410 |
Blood cholesterol increased | 54.08 | 9.65 | 54 | 198247 | 39959 | 46447802 |
Palmar-plantar erythrodysaesthesia syndrome | 53.69 | 9.65 | 200 | 198101 | 20251 | 46467510 |
Knee arthroplasty | 53.33 | 9.65 | 17 | 198284 | 23648 | 46464113 |
Injection site pruritus | 53.30 | 9.65 | 54 | 198247 | 39689 | 46448072 |
Sepsis | 52.69 | 9.65 | 841 | 197460 | 135173 | 46352588 |
Full blood count decreased | 52.41 | 9.65 | 210 | 198091 | 22001 | 46465760 |
Femur fracture | 52.25 | 9.65 | 48 | 198253 | 36949 | 46450812 |
Pancytopenia | 52.21 | 9.65 | 572 | 197729 | 84486 | 46403275 |
Drug interaction | 52.21 | 9.65 | 581 | 197720 | 202513 | 46285248 |
Arthritis | 52.00 | 9.65 | 162 | 198139 | 77154 | 46410607 |
Loss of personal independence in daily activities | 51.58 | 9.65 | 103 | 198198 | 57080 | 46430681 |
Swelling | 50.76 | 9.65 | 315 | 197986 | 124196 | 46363565 |
Intentional product misuse | 50.61 | 9.65 | 76 | 198225 | 47052 | 46440709 |
Glossodynia | 50.18 | 9.65 | 69 | 198232 | 44304 | 46443457 |
Chills | 50.15 | 9.65 | 626 | 197675 | 95406 | 46392355 |
Pulmonary embolism | 50.11 | 9.65 | 692 | 197609 | 107893 | 46379868 |
Wound | 49.98 | 9.65 | 65 | 198236 | 42737 | 46445024 |
Osteoarthritis | 49.93 | 9.65 | 119 | 198182 | 61906 | 46425855 |
Accidental exposure to product | 49.58 | 9.65 | 14 | 198287 | 21067 | 46466694 |
Hypomagnesaemia | 49.25 | 9.65 | 206 | 198095 | 22004 | 46465757 |
Failure to thrive | 48.34 | 9.65 | 95 | 198206 | 6569 | 46481192 |
Inflammation | 48.31 | 9.65 | 83 | 198218 | 48698 | 46439063 |
C-reactive protein increased | 48.29 | 9.65 | 111 | 198190 | 58479 | 46429282 |
Hepatic enzyme increased | 47.16 | 9.65 | 183 | 198118 | 81604 | 46406157 |
Osteoporosis | 47.08 | 9.65 | 62 | 198239 | 40546 | 46447215 |
Sopor | 46.94 | 9.65 | 13 | 198288 | 19815 | 46467946 |
Dysgeusia | 46.46 | 9.65 | 313 | 197988 | 40178 | 46447583 |
Asthenia | 46.34 | 9.65 | 1685 | 196616 | 309390 | 46178371 |
Pericarditis | 45.98 | 9.65 | 22 | 198279 | 23905 | 46463856 |
Drug resistance | 45.85 | 9.65 | 9 | 198292 | 17359 | 46470402 |
Diabetes mellitus | 43.61 | 9.65 | 92 | 198209 | 49973 | 46437788 |
Hypokalaemia | 43.50 | 9.65 | 568 | 197733 | 87456 | 46400305 |
Nasopharyngitis | 43.02 | 9.65 | 432 | 197869 | 153566 | 46334195 |
Tachycardia | 42.81 | 9.65 | 627 | 197674 | 98995 | 46388766 |
Dilatation intrahepatic duct acquired | 42.50 | 9.65 | 31 | 198270 | 725 | 46487036 |
Opisthotonus | 42.30 | 9.65 | 23 | 198278 | 314 | 46487447 |
Clonus | 42.30 | 9.65 | 68 | 198233 | 4012 | 46483749 |
Lactic acidosis | 42.22 | 9.65 | 49 | 198252 | 33860 | 46453901 |
Injection site bruising | 41.73 | 9.65 | 54 | 198247 | 35582 | 46452179 |
Psoriatic arthropathy | 40.70 | 9.65 | 57 | 198244 | 36322 | 46451439 |
Neoplasm progression | 40.62 | 9.65 | 222 | 198079 | 26461 | 46461300 |
Wrong technique in product usage process | 40.26 | 9.65 | 109 | 198192 | 54313 | 46433448 |
Mental status changes | 39.92 | 9.65 | 288 | 198013 | 37800 | 46449961 |
Dyspnoea | 39.84 | 9.65 | 2618 | 195683 | 512930 | 45974831 |
Gait disturbance | 39.13 | 9.65 | 411 | 197890 | 144852 | 46342909 |
Hypotension | 38.64 | 9.65 | 1276 | 197025 | 231313 | 46256448 |
Ascites | 38.55 | 9.65 | 277 | 198024 | 36307 | 46451454 |
Long QT syndrome | 38.52 | 9.65 | 56 | 198245 | 3024 | 46484737 |
Otitis media chronic | 38.30 | 9.65 | 16 | 198285 | 115 | 46487646 |
Respiratory distress | 37.99 | 9.65 | 249 | 198052 | 31667 | 46456094 |
Dermatitis diaper | 37.90 | 9.65 | 18 | 198283 | 181 | 46487580 |
Hospice care | 37.83 | 9.65 | 75 | 198226 | 5220 | 46482541 |
Neutropenic colitis | 37.73 | 9.65 | 47 | 198254 | 2185 | 46485576 |
Coronary artery disease | 37.64 | 9.65 | 53 | 198248 | 33699 | 46454062 |
Basal cell carcinoma | 37.62 | 9.65 | 20 | 198281 | 20467 | 46467294 |
Osteonecrosis of jaw | 37.40 | 9.65 | 55 | 198246 | 34347 | 46453414 |
Anaemia | 36.97 | 9.65 | 1381 | 196920 | 254398 | 46233363 |
Ventricular fibrillation | 36.74 | 9.65 | 120 | 198181 | 11376 | 46476385 |
Hepatic function abnormal | 36.48 | 9.65 | 56 | 198245 | 34365 | 46453396 |
Atrial septal defect | 36.31 | 9.65 | 82 | 198219 | 6250 | 46481511 |
Hip arthroplasty | 35.82 | 9.65 | 16 | 198285 | 18096 | 46469665 |
Off label use | 35.77 | 9.65 | 1287 | 197014 | 378554 | 46109207 |
Electrocardiogram QRS complex | 35.73 | 9.65 | 8 | 198293 | 0 | 46487761 |
Renal impairment | 35.27 | 9.65 | 179 | 198122 | 74193 | 46413568 |
Oxygen saturation decreased | 34.46 | 9.65 | 447 | 197854 | 68717 | 46419044 |
Drug reaction with eosinophilia and systemic symptoms | 34.37 | 9.65 | 45 | 198256 | 29503 | 46458258 |
Interstitial lung disease | 34.21 | 9.65 | 116 | 198185 | 53833 | 46433928 |
Anxiety | 34.09 | 9.65 | 1013 | 197288 | 180944 | 46306817 |
Ileus | 34.01 | 9.65 | 134 | 198167 | 13930 | 46473831 |
Segmental diverticular colitis | 33.71 | 9.65 | 15 | 198286 | 128 | 46487633 |
Rhabdomyolysis | 33.26 | 9.65 | 81 | 198220 | 41828 | 46445933 |
Impaired gastric emptying | 33.10 | 9.65 | 92 | 198209 | 7980 | 46479781 |
Hypophagia | 32.11 | 9.65 | 224 | 198077 | 29082 | 46458679 |
Right ventricular hypertrophy | 32.01 | 9.65 | 25 | 198276 | 650 | 46487111 |
Unresponsive to stimuli | 31.84 | 9.65 | 240 | 198061 | 31934 | 46455827 |
Stomatitis | 31.79 | 9.65 | 436 | 197865 | 67861 | 46419900 |
Impaired healing | 31.59 | 9.65 | 68 | 198233 | 36675 | 46451086 |
Hyperemesis gravidarum | 31.05 | 9.65 | 22 | 198279 | 491 | 46487270 |
Anaphylactic reaction | 30.68 | 9.65 | 353 | 197948 | 52759 | 46435002 |
Lupus vasculitis | 30.29 | 9.65 | 21 | 198280 | 452 | 46487309 |
Retching | 29.65 | 9.65 | 122 | 198179 | 12935 | 46474826 |
Pain in extremity | 29.44 | 9.65 | 855 | 197446 | 257825 | 46229936 |
Abdominal discomfort | 29.43 | 9.65 | 458 | 197843 | 150707 | 46337054 |
Bone erosion | 29.33 | 9.65 | 3 | 198298 | 9440 | 46478321 |
Product use in unapproved indication | 28.74 | 9.65 | 541 | 197760 | 89732 | 46398029 |
Blood pressure systolic increased | 28.48 | 9.65 | 49 | 198252 | 28738 | 46459023 |
Lower respiratory tract infection | 28.20 | 9.65 | 129 | 198172 | 54960 | 46432801 |
Clostridium difficile infection | 28.16 | 9.65 | 193 | 198108 | 24910 | 46462851 |
Bone density decreased | 28.08 | 9.65 | 4 | 198297 | 9748 | 46478013 |
Joint stiffness | 27.88 | 9.65 | 45 | 198256 | 27063 | 46460698 |
Cholecystitis chronic | 27.83 | 9.65 | 103 | 198198 | 10396 | 46477365 |
Rheumatoid nodule | 27.67 | 9.65 | 3 | 198298 | 9017 | 46478744 |
Apnoea | 27.53 | 9.65 | 81 | 198220 | 7258 | 46480503 |
Bronchospasm | 26.88 | 9.65 | 135 | 198166 | 15572 | 46472189 |
Laevocardia | 26.79 | 9.65 | 6 | 198295 | 0 | 46487761 |
Procedural vomiting | 26.73 | 9.65 | 20 | 198281 | 487 | 46487274 |
Poisoning | 26.69 | 9.65 | 13 | 198288 | 13981 | 46473780 |
Clostridium difficile colitis | 26.67 | 9.65 | 152 | 198149 | 18401 | 46469360 |
Pedal pulse abnormal | 26.52 | 9.65 | 13 | 198288 | 141 | 46487620 |
Sinus tachycardia | 26.44 | 9.65 | 170 | 198131 | 21479 | 46466282 |
Fracture | 26.20 | 9.65 | 19 | 198282 | 16452 | 46471309 |
Respiratory syncytial virus infection | 25.95 | 9.65 | 61 | 198240 | 4774 | 46482987 |
Schizophrenia | 25.91 | 9.65 | 3 | 198298 | 8565 | 46479196 |
Blood potassium decreased | 25.70 | 9.65 | 261 | 198040 | 37802 | 46449959 |
Type I hypersensitivity | 25.56 | 9.65 | 40 | 198261 | 2306 | 46485455 |
Type 2 diabetes mellitus | 25.53 | 9.65 | 28 | 198273 | 19847 | 46467914 |
Neonatal tachypnoea | 25.32 | 9.65 | 10 | 198291 | 61 | 46487700 |
Computerised tomogram thorax abnormal | 25.18 | 9.65 | 30 | 198271 | 1331 | 46486430 |
Feeling hot | 25.10 | 9.65 | 259 | 198042 | 37669 | 46450092 |
Jaundice neonatal | 24.76 | 9.65 | 24 | 198277 | 839 | 46486922 |
Deep vein thrombosis | 24.68 | 9.65 | 476 | 197825 | 79297 | 46408464 |
Sense of oppression | 24.53 | 9.65 | 26 | 198275 | 1013 | 46486748 |
Acute respiratory failure | 24.29 | 9.65 | 209 | 198092 | 28929 | 46458832 |
Lip pruritus | 24.23 | 9.65 | 19 | 198282 | 497 | 46487264 |
Coma | 24.08 | 9.65 | 147 | 198154 | 58202 | 46429559 |
Pancreatitis | 23.89 | 9.65 | 287 | 198014 | 43340 | 46444421 |
Cestode infection | 23.87 | 9.65 | 15 | 198286 | 272 | 46487489 |
Right ventricular enlargement | 23.77 | 9.65 | 15 | 198286 | 274 | 46487487 |
Leukopenia | 23.65 | 9.65 | 415 | 197886 | 67928 | 46419833 |
Eustachian tube dysfunction | 23.59 | 9.65 | 17 | 198284 | 390 | 46487371 |
Bursitis | 23.30 | 9.65 | 30 | 198271 | 19812 | 46467949 |
Hypercholesterolaemia | 23.09 | 9.65 | 10 | 198291 | 11520 | 46476241 |
Therapy interrupted | 23.08 | 9.65 | 99 | 198202 | 10692 | 46477069 |
Product substitution issue | 23.06 | 9.65 | 18 | 198283 | 15013 | 46472748 |
Calcium ionised decreased | 23.01 | 9.65 | 14 | 198287 | 239 | 46487522 |
Somnolence | 23.01 | 9.65 | 498 | 197803 | 156023 | 46331738 |
Intestinal perforation | 22.79 | 9.65 | 99 | 198202 | 10752 | 46477009 |
Osteonecrosis | 22.67 | 9.65 | 47 | 198254 | 25697 | 46462064 |
Back pain | 22.63 | 9.65 | 1100 | 197201 | 208939 | 46278822 |
Metastases to meninges | 22.61 | 9.65 | 34 | 198267 | 1893 | 46485868 |
Poor feeding infant | 22.55 | 9.65 | 13 | 198288 | 200 | 46487561 |
Aplastic anaemia | 22.26 | 9.65 | 74 | 198227 | 7079 | 46480682 |
Otitis media acute | 22.10 | 9.65 | 23 | 198278 | 877 | 46486884 |
Medication error | 22.05 | 9.65 | 63 | 198238 | 30848 | 46456913 |
Gastroenteritis radiation | 22.03 | 9.65 | 18 | 198283 | 500 | 46487261 |
Blood bilirubin increased | 21.94 | 9.65 | 232 | 198069 | 33952 | 46453809 |
Sedation | 21.76 | 9.65 | 40 | 198261 | 22870 | 46464891 |
Blood pressure fluctuation | 21.76 | 9.65 | 62 | 198239 | 30386 | 46457375 |
Injection site haemorrhage | 21.65 | 9.65 | 34 | 198267 | 20675 | 46467086 |
Bacteraemia | 21.60 | 9.65 | 118 | 198183 | 14061 | 46473700 |
Paranoia | 21.53 | 9.65 | 9 | 198292 | 10588 | 46477173 |
Drug dependence | 21.45 | 9.65 | 32 | 198269 | 19869 | 46467892 |
Cerebrovascular accident | 21.43 | 9.65 | 301 | 198000 | 100738 | 46387023 |
Pulmonary artery stenosis congenital | 21.42 | 9.65 | 13 | 198288 | 221 | 46487540 |
Aplasia | 21.28 | 9.65 | 47 | 198254 | 3529 | 46484232 |
Duodenal ulcer perforation | 21.23 | 9.65 | 5 | 198296 | 8497 | 46479264 |
Stress | 21.21 | 9.65 | 130 | 198171 | 51421 | 46436340 |
Procedural nausea | 21.14 | 9.65 | 20 | 198281 | 678 | 46487083 |
Troponin increased | 20.98 | 9.65 | 77 | 198224 | 7739 | 46480022 |
Malnutrition | 20.97 | 9.65 | 116 | 198185 | 13887 | 46473874 |
Glaucoma | 20.93 | 9.65 | 22 | 198279 | 15899 | 46471862 |
Joint range of motion decreased | 20.91 | 9.65 | 20 | 198281 | 15104 | 46472657 |
Hypoglycaemia | 20.85 | 9.65 | 140 | 198161 | 54209 | 46433552 |
Herpes zoster | 20.81 | 9.65 | 186 | 198115 | 67686 | 46420075 |
Fibromyalgia | 20.75 | 9.65 | 82 | 198219 | 36381 | 46451380 |
Long QT syndrome congenital | 20.73 | 9.65 | 7 | 198294 | 25 | 46487736 |
Ventricular septal defect | 20.68 | 9.65 | 50 | 198251 | 3984 | 46483777 |
Cerebral microhaemorrhage | 20.60 | 9.65 | 10 | 198291 | 106 | 46487655 |
Respiratory failure | 20.58 | 9.65 | 538 | 197763 | 94278 | 46393483 |
Injection site warmth | 20.49 | 9.65 | 17 | 198284 | 13755 | 46474006 |
Multiple sclerosis | 20.40 | 9.65 | 47 | 198254 | 24744 | 46463017 |
Cardiac failure | 20.39 | 9.65 | 229 | 198072 | 79719 | 46408042 |
Cerebral infarction | 20.29 | 9.65 | 43 | 198258 | 23323 | 46464438 |
Gallbladder injury | 20.20 | 9.65 | 27 | 198274 | 1347 | 46486414 |
Administration site oedema | 20.11 | 9.65 | 7 | 198294 | 28 | 46487733 |
Venoocclusive liver disease | 20.01 | 9.65 | 51 | 198250 | 4200 | 46483561 |
Plantar erythema | 19.98 | 9.65 | 13 | 198288 | 251 | 46487510 |
Product prescribing error | 19.94 | 9.65 | 34 | 198267 | 20013 | 46467748 |
Amputation stump pain | 19.73 | 9.65 | 7 | 198294 | 30 | 46487731 |
Vascular access site thrombosis | 19.73 | 9.65 | 7 | 198294 | 30 | 46487731 |
Pneumonitis | 19.73 | 9.65 | 196 | 198105 | 28224 | 46459537 |
Breast cancer | 19.67 | 9.65 | 113 | 198188 | 45405 | 46442356 |
Treatment noncompliance | 19.48 | 9.65 | 63 | 198238 | 29668 | 46458093 |
Insomnia | 19.27 | 9.65 | 543 | 197758 | 164381 | 46323380 |
Hyperkalaemia | 19.27 | 9.65 | 131 | 198170 | 50578 | 46437183 |
Blood magnesium decreased | 19.18 | 9.65 | 95 | 198206 | 10897 | 46476864 |
Vasculitis | 19.11 | 9.65 | 18 | 198283 | 13693 | 46474068 |
Glioblastoma multiforme | 19.06 | 9.65 | 21 | 198280 | 855 | 46486906 |
Proctalgia | 19.02 | 9.65 | 54 | 198247 | 4742 | 46483019 |
Infusion site streaking | 18.78 | 9.65 | 14 | 198287 | 339 | 46487422 |
Hair colour changes | 18.76 | 9.65 | 30 | 198271 | 1762 | 46485999 |
Laryngeal discomfort | 18.67 | 9.65 | 13 | 198288 | 282 | 46487479 |
Product quality issue | 18.53 | 9.65 | 83 | 198218 | 35565 | 46452196 |
Red blood cell count decreased | 18.47 | 9.65 | 216 | 198085 | 32407 | 46455354 |
Taste disorder | 18.46 | 9.65 | 61 | 198240 | 5817 | 46481944 |
Oral pain | 18.19 | 9.65 | 173 | 198128 | 24624 | 46463137 |
Transplant rejection | 18.17 | 9.65 | 9 | 198292 | 9587 | 46478174 |
Feeding intolerance | 18.16 | 9.65 | 16 | 198285 | 494 | 46487267 |
Suicidal ideation | 17.95 | 9.65 | 153 | 198148 | 56229 | 46431532 |
Product complaint | 17.93 | 9.65 | 15 | 198286 | 12086 | 46475675 |
Burkholderia cepacia complex infection | 17.93 | 9.65 | 10 | 198291 | 144 | 46487617 |
Cholecystitis | 17.91 | 9.65 | 114 | 198187 | 14352 | 46473409 |
Fever neonatal | 17.86 | 9.65 | 4 | 198297 | 0 | 46487761 |
Cytomegalovirus infection | 17.84 | 9.65 | 31 | 198270 | 18113 | 46469648 |
Adenoidal hypertrophy | 17.82 | 9.65 | 7 | 198294 | 42 | 46487719 |
Congenital pulmonary valve atresia | 17.81 | 9.65 | 8 | 198293 | 70 | 46487691 |
Magnesium deficiency | 17.76 | 9.65 | 15 | 198286 | 437 | 46487324 |
Neutropenic infection | 17.71 | 9.65 | 23 | 198278 | 1115 | 46486646 |
Myalgia | 17.69 | 9.65 | 393 | 197908 | 122695 | 46365066 |
Drug level increased | 17.69 | 9.65 | 32 | 198269 | 18409 | 46469352 |
No adverse event | 17.61 | 9.65 | 80 | 198221 | 34151 | 46453610 |
Desmoplastic small round cell tumour | 17.57 | 9.65 | 10 | 198291 | 150 | 46487611 |
Melaena | 17.41 | 9.65 | 60 | 198241 | 27712 | 46460049 |
Cervix neoplasm | 17.29 | 9.65 | 11 | 198290 | 204 | 46487557 |
Bulimia nervosa | 17.25 | 9.65 | 16 | 198285 | 529 | 46487232 |
Aggression | 17.23 | 9.65 | 45 | 198256 | 22699 | 46465062 |
Congenital anomaly in offspring | 17.23 | 9.65 | 10 | 198291 | 156 | 46487605 |
Hydronephrosis | 17.21 | 9.65 | 77 | 198224 | 8468 | 46479293 |
Transmission of an infectious agent via product | 17.21 | 9.65 | 9 | 198292 | 113 | 46487648 |
Vein discolouration | 17.11 | 9.65 | 10 | 198291 | 158 | 46487603 |
Drug eruption | 17.10 | 9.65 | 41 | 198260 | 21288 | 46466473 |
Lupus-like syndrome | 17.03 | 9.65 | 6 | 198295 | 7838 | 46479923 |
Pulmonary valve stenosis | 16.98 | 9.65 | 13 | 198288 | 328 | 46487433 |
Electrolyte depletion | 16.95 | 9.65 | 10 | 198291 | 161 | 46487600 |
Osteopenia | 16.66 | 9.65 | 29 | 198272 | 16932 | 46470829 |
Pulmonary fibrosis | 16.60 | 9.65 | 38 | 198263 | 20054 | 46467707 |
Depressed level of consciousness | 16.56 | 9.65 | 126 | 198175 | 47443 | 46440318 |
Irritability | 16.53 | 9.65 | 65 | 198236 | 28881 | 46458880 |
Foot deformity | 16.44 | 9.65 | 25 | 198276 | 15400 | 46472361 |
Toxic encephalopathy | 16.32 | 9.65 | 53 | 198248 | 5009 | 46482752 |
Pathogen resistance | 16.29 | 9.65 | 3 | 198298 | 6057 | 46481704 |
Inappropriate schedule of product administration | 16.27 | 9.65 | 187 | 198114 | 64826 | 46422935 |
Coronary artery occlusion | 16.27 | 9.65 | 7 | 198294 | 8095 | 46479666 |
Vascular access site infection | 16.17 | 9.65 | 6 | 198295 | 30 | 46487731 |
Cerebellar stroke | 16.12 | 9.65 | 10 | 198291 | 177 | 46487584 |
Eating disorder | 16.04 | 9.65 | 112 | 198189 | 14542 | 46473219 |
IIIrd nerve paresis | 15.99 | 9.65 | 8 | 198293 | 91 | 46487670 |
Pneumonia | 15.88 | 9.65 | 1828 | 196473 | 374492 | 46113269 |
Immune effector cell-associated neurotoxicity syndrome | 15.74 | 9.65 | 17 | 198284 | 677 | 46487084 |
Pharyngeal paraesthesia | 15.70 | 9.65 | 22 | 198279 | 1148 | 46486613 |
Nail pigmentation | 15.69 | 9.65 | 10 | 198291 | 186 | 46487575 |
Carpal tunnel syndrome | 15.68 | 9.65 | 27 | 198274 | 15832 | 46471929 |
Bone disorder | 15.67 | 9.65 | 39 | 198262 | 19994 | 46467767 |
Helicobacter infection | 15.67 | 9.65 | 16 | 198285 | 11720 | 46476041 |
Electrolyte imbalance | 15.66 | 9.65 | 126 | 198175 | 17100 | 46470661 |
Haematoma | 15.51 | 9.65 | 76 | 198225 | 31796 | 46455965 |
Glycosylated haemoglobin increased | 15.49 | 9.65 | 14 | 198287 | 10862 | 46476899 |
Drug clearance decreased | 15.47 | 9.65 | 21 | 198280 | 1063 | 46486698 |
Skin ulcer | 15.45 | 9.65 | 78 | 198223 | 32380 | 46455381 |
Hallucination, visual | 15.43 | 9.65 | 33 | 198268 | 17840 | 46469921 |
Epiglottic oedema | 15.41 | 9.65 | 6 | 198295 | 35 | 46487726 |
Seizure like phenomena | 15.32 | 9.65 | 20 | 198281 | 975 | 46486786 |
Sinusitis | 15.22 | 9.65 | 427 | 197874 | 129341 | 46358420 |
Biliary obstruction | 15.14 | 9.65 | 33 | 198268 | 2456 | 46485305 |
Right ventricle outflow tract obstruction | 15.11 | 9.65 | 4 | 198297 | 4 | 46487757 |
Right ventricular dilatation | 15.06 | 9.65 | 19 | 198282 | 895 | 46486866 |
Device related infection | 15.04 | 9.65 | 146 | 198155 | 20895 | 46466866 |
Gangrene | 14.99 | 9.65 | 49 | 198252 | 4646 | 46483115 |
Chest discomfort | 14.89 | 9.65 | 495 | 197806 | 89774 | 46397987 |
Liver disorder | 14.76 | 9.65 | 95 | 198206 | 37151 | 46450610 |
Delirium | 14.73 | 9.65 | 95 | 198206 | 37133 | 46450628 |
Haemoglobin decreased | 14.65 | 9.65 | 679 | 197622 | 128270 | 46359491 |
Eosinophilia | 14.58 | 9.65 | 38 | 198263 | 19179 | 46468582 |
Enteritis | 14.47 | 9.65 | 62 | 198239 | 6693 | 46481068 |
Premenstrual syndrome | 14.42 | 9.65 | 16 | 198285 | 657 | 46487104 |
Tendonitis | 14.40 | 9.65 | 24 | 198277 | 14253 | 46473508 |
Pityriasis rosea | 14.35 | 9.65 | 7 | 198294 | 75 | 46487686 |
Chronic obstructive pulmonary disease | 14.33 | 9.65 | 166 | 198135 | 57467 | 46430294 |
Venoocclusive disease | 14.33 | 9.65 | 28 | 198273 | 1928 | 46485833 |
Infection | 14.32 | 9.65 | 445 | 197856 | 133147 | 46354614 |
Colitis microscopic | 14.26 | 9.65 | 5 | 198296 | 6551 | 46481210 |
Rotator cuff syndrome | 14.14 | 9.65 | 17 | 198284 | 11566 | 46476195 |
Psychotic disorder | 14.09 | 9.65 | 49 | 198252 | 22572 | 46465189 |
Developmental delay | 14.07 | 9.65 | 21 | 198280 | 1161 | 46486600 |
Hallucination, auditory | 13.98 | 9.65 | 15 | 198286 | 10741 | 46477020 |
Ageusia | 13.95 | 9.65 | 90 | 198211 | 11382 | 46476379 |
Bone pain | 13.89 | 9.65 | 278 | 198023 | 46612 | 46441149 |
Injection site rash | 13.81 | 9.65 | 29 | 198272 | 15784 | 46471977 |
Metastases to peritoneum | 13.77 | 9.65 | 33 | 198268 | 2615 | 46485146 |
Epilepsy | 13.75 | 9.65 | 53 | 198248 | 23685 | 46464076 |
Injection site phlebitis | 13.71 | 9.65 | 8 | 198293 | 126 | 46487635 |
Cardiac murmur | 13.59 | 9.65 | 89 | 198212 | 11315 | 46476446 |
Uterine perforation | 13.54 | 9.65 | 64 | 198237 | 7203 | 46480558 |
Dacryostenosis congenital | 13.50 | 9.65 | 4 | 198297 | 8 | 46487753 |
Musculoskeletal pain | 13.46 | 9.65 | 213 | 198088 | 69915 | 46417846 |
Cleft palate | 13.45 | 9.65 | 18 | 198283 | 899 | 46486862 |
Right ventricular hypertension | 13.40 | 9.65 | 3 | 198298 | 0 | 46487761 |
Pulmonary oedema neonatal | 13.40 | 9.65 | 3 | 198298 | 0 | 46487761 |
Wolff-Parkinson-White syndrome congenital | 13.40 | 9.65 | 3 | 198298 | 0 | 46487761 |
Univentricular heart | 13.40 | 9.65 | 3 | 198298 | 0 | 46487761 |
Oedema neonatal | 13.40 | 9.65 | 3 | 198298 | 0 | 46487761 |
Neonatal respiratory distress | 13.39 | 9.65 | 8 | 198293 | 132 | 46487629 |
Foetal exposure during pregnancy | 13.38 | 9.65 | 194 | 198107 | 30553 | 46457208 |
Dementia | 13.36 | 9.65 | 27 | 198274 | 14903 | 46472858 |
Neutrophil count abnormal | 13.25 | 9.65 | 31 | 198270 | 2419 | 46485342 |
Tracheal injury | 13.21 | 9.65 | 6 | 198295 | 54 | 46487707 |
Peripheral swelling | 13.19 | 9.65 | 543 | 197758 | 157528 | 46330233 |
Food intolerance | 13.15 | 9.65 | 30 | 198271 | 2302 | 46485459 |
Obstructive airways disorder | 13.11 | 9.65 | 23 | 198278 | 13389 | 46474372 |
Pericardial effusion | 13.10 | 9.65 | 166 | 198135 | 25377 | 46462384 |
Discomfort | 12.98 | 9.65 | 131 | 198170 | 46539 | 46441222 |
Meningitis streptococcal | 12.98 | 9.65 | 8 | 198293 | 140 | 46487621 |
Tumour lysis syndrome | 12.96 | 9.65 | 63 | 198238 | 7173 | 46480588 |
Wrist fracture | 12.89 | 9.65 | 18 | 198283 | 11485 | 46476276 |
Cardiac failure congestive | 12.88 | 9.65 | 294 | 198007 | 91456 | 46396305 |
Cataract | 12.83 | 9.65 | 127 | 198174 | 45288 | 46442473 |
Laboratory test abnormal | 12.81 | 9.65 | 151 | 198150 | 22696 | 46465065 |
Poisoning deliberate | 12.79 | 9.65 | 9 | 198292 | 7917 | 46479844 |
Blood count abnormal | 12.75 | 9.65 | 124 | 198177 | 17754 | 46470007 |
Sleep disorder | 12.75 | 9.65 | 132 | 198169 | 46663 | 46441098 |
Periorbital cellulitis | 12.68 | 9.65 | 13 | 198288 | 487 | 46487274 |
Sciatica | 12.67 | 9.65 | 40 | 198261 | 18980 | 46468781 |
Subchorionic haemorrhage | 12.66 | 9.65 | 6 | 198295 | 60 | 46487701 |
Pneumonia respiratory syncytial viral | 12.65 | 9.65 | 15 | 198286 | 662 | 46487099 |
Incorrect dose administered | 12.61 | 9.65 | 128 | 198173 | 45422 | 46442339 |
Transverse sinus thrombosis | 12.60 | 9.65 | 15 | 198286 | 665 | 46487096 |
Gastroenteritis viral | 12.59 | 9.65 | 125 | 198176 | 17994 | 46469767 |
Epistaxis | 12.56 | 9.65 | 360 | 197941 | 63945 | 46423816 |
Labelled drug-drug interaction medication error | 12.50 | 9.65 | 12 | 198289 | 9049 | 46478712 |
Cyanosis | 12.50 | 9.65 | 113 | 198188 | 15858 | 46471903 |
Morning sickness | 12.49 | 9.65 | 15 | 198286 | 671 | 46487090 |
Right atrial dilatation | 12.44 | 9.65 | 13 | 198288 | 498 | 46487263 |
Cyanosis neonatal | 12.43 | 9.65 | 9 | 198292 | 208 | 46487553 |
Blood glucose increased | 12.42 | 9.65 | 223 | 198078 | 71790 | 46415971 |
Non-cardiac chest pain | 12.42 | 9.65 | 55 | 198246 | 6023 | 46481738 |
Sensitivity to weather change | 12.36 | 9.65 | 4 | 198297 | 5512 | 46482249 |
Skin necrosis | 12.34 | 9.65 | 11 | 198290 | 8593 | 46479168 |
Pulmonary valve stenosis congenital | 12.31 | 9.65 | 8 | 198293 | 154 | 46487607 |
Osteomyelitis | 12.31 | 9.65 | 51 | 198250 | 22332 | 46465429 |
Arteriosclerosis coronary artery | 12.22 | 9.65 | 10 | 198291 | 8146 | 46479615 |
Disease recurrence | 12.20 | 9.65 | 39 | 198262 | 18432 | 46469329 |
Intraocular pressure increased | 12.20 | 9.65 | 5 | 198296 | 5952 | 46481809 |
Injection site urticaria | 12.18 | 9.65 | 20 | 198281 | 11947 | 46475814 |
Blood creatine increased | 12.14 | 9.65 | 45 | 198256 | 4545 | 46483216 |
Sputum abnormal | 12.13 | 9.65 | 11 | 198290 | 353 | 46487408 |
Stridor | 12.06 | 9.65 | 35 | 198266 | 3112 | 46484649 |
Joint dislocation | 12.04 | 9.65 | 18 | 198283 | 11168 | 46476593 |
Grunting | 12.00 | 9.65 | 9 | 198292 | 220 | 46487541 |
Gait inability | 11.90 | 9.65 | 94 | 198207 | 35109 | 46452652 |
Muscle injury | 11.88 | 9.65 | 3 | 198298 | 4863 | 46482898 |
Protein urine | 11.88 | 9.65 | 14 | 198287 | 614 | 46487147 |
Macular degeneration | 11.87 | 9.65 | 8 | 198293 | 7197 | 46480564 |
Haemorrhoids | 11.84 | 9.65 | 127 | 198174 | 18650 | 46469111 |
Cardiac arrest | 11.82 | 9.65 | 483 | 197818 | 89916 | 46397845 |
Product storage error | 11.73 | 9.65 | 20 | 198281 | 11772 | 46475989 |
Neonatal tachycardia | 11.69 | 9.65 | 4 | 198297 | 15 | 46487746 |
Therapy non-responder | 11.66 | 9.65 | 115 | 198186 | 41037 | 46446724 |
Haemophagocytic lymphohistiocytosis | 11.57 | 9.65 | 11 | 198290 | 8331 | 46479430 |
Acute myeloid leukaemia | 11.53 | 9.65 | 110 | 198191 | 15668 | 46472093 |
Jugular vein thrombosis | 11.52 | 9.65 | 31 | 198270 | 2639 | 46485122 |
Vascular device infection | 11.50 | 9.65 | 37 | 198264 | 3480 | 46484281 |
Sleep disorder due to general medical condition, insomnia type | 11.42 | 9.65 | 4 | 198297 | 5245 | 46482516 |
Hypothyroidism | 11.39 | 9.65 | 82 | 198219 | 31256 | 46456505 |
Chest pain | 11.39 | 9.65 | 883 | 197418 | 175441 | 46312320 |
Intercepted product administration error | 11.36 | 9.65 | 6 | 198295 | 77 | 46487684 |
Tumour marker increased | 11.35 | 9.65 | 37 | 198264 | 3504 | 46484257 |
Electrocardiogram QT shortened | 11.33 | 9.65 | 7 | 198294 | 123 | 46487638 |
Congenital tongue anomaly | 11.33 | 9.65 | 3 | 198298 | 3 | 46487758 |
Hypofibrinogenaemia | 11.32 | 9.65 | 18 | 198283 | 1052 | 46486709 |
Superior sagittal sinus thrombosis | 11.32 | 9.65 | 16 | 198285 | 842 | 46486919 |
Splinter haemorrhages | 11.30 | 9.65 | 4 | 198297 | 17 | 46487744 |
Meningioma malignant | 11.30 | 9.65 | 4 | 198297 | 17 | 46487744 |
International normalised ratio increased | 11.29 | 9.65 | 136 | 198165 | 46747 | 46441014 |
Palmar erythema | 11.23 | 9.65 | 21 | 198280 | 1399 | 46486362 |
Transplant dysfunction | 11.21 | 9.65 | 3 | 198298 | 4679 | 46483082 |
Injection site haematoma | 11.17 | 9.65 | 6 | 198295 | 6106 | 46481655 |
Altered state of consciousness | 11.17 | 9.65 | 56 | 198245 | 23292 | 46464469 |
Onychalgia | 11.17 | 9.65 | 14 | 198287 | 655 | 46487106 |
Multiple congenital abnormalities | 11.17 | 9.65 | 12 | 198289 | 475 | 46487286 |
Chronic hepatitis B | 11.14 | 9.65 | 9 | 198292 | 246 | 46487515 |
Teething | 11.12 | 9.65 | 4 | 198297 | 18 | 46487743 |
Neutrophil percentage abnormal | 11.12 | 9.65 | 4 | 198297 | 18 | 46487743 |
Alopecia | 11.11 | 9.65 | 570 | 197731 | 161844 | 46325917 |
Fluid replacement | 11.10 | 9.65 | 5 | 198296 | 44 | 46487717 |
Eye irritation | 11.03 | 9.65 | 35 | 198266 | 16579 | 46471182 |
Congenital tricuspid valve atresia | 11.01 | 9.65 | 5 | 198296 | 45 | 46487716 |
Neuroleptic malignant syndrome | 10.94 | 9.65 | 19 | 198282 | 11103 | 46476658 |
Anaphylactic shock | 10.93 | 9.65 | 133 | 198168 | 20141 | 46467620 |
Plasmacytoma | 10.93 | 9.65 | 29 | 198272 | 2448 | 46485313 |
Pregnancy | 10.87 | 9.65 | 69 | 198232 | 27068 | 46460693 |
Right atrial enlargement | 10.84 | 9.65 | 6 | 198295 | 85 | 46487676 |
Dysphemia | 10.80 | 9.65 | 28 | 198273 | 2330 | 46485431 |
Anaesthetic complication neurological | 10.79 | 9.65 | 8 | 198293 | 192 | 46487569 |
Peripheral sensory neuropathy | 10.77 | 9.65 | 56 | 198245 | 6547 | 46481214 |
Haemorrhage | 10.75 | 9.65 | 166 | 198135 | 54703 | 46433058 |
High density lipoprotein abnormal | 10.73 | 9.65 | 5 | 198296 | 48 | 46487713 |
Depression | 10.70 | 9.65 | 602 | 197699 | 169502 | 46318259 |
Calcium ionised increased | 10.63 | 9.65 | 7 | 198294 | 138 | 46487623 |
Dextrocardia | 10.62 | 9.65 | 4 | 198297 | 21 | 46487740 |
Tuberculosis | 10.59 | 9.65 | 17 | 198284 | 10248 | 46477513 |
Incorrect route of product administration | 10.54 | 9.65 | 35 | 198266 | 16348 | 46471413 |
Hyperbilirubinaemia neonatal | 10.50 | 9.65 | 10 | 198291 | 342 | 46487419 |
Pulseless electrical activity | 10.49 | 9.65 | 59 | 198242 | 7108 | 46480653 |
Small intestine operation | 10.48 | 9.65 | 3 | 198298 | 5 | 46487756 |
Lymphorrhoea | 10.47 | 9.65 | 5 | 198296 | 51 | 46487710 |
Hypermagnesaemia | 10.44 | 9.65 | 16 | 198285 | 906 | 46486855 |
Left ventricular dysfunction | 10.43 | 9.65 | 77 | 198224 | 10178 | 46477583 |
Ankylosing spondylitis | 10.42 | 9.65 | 8 | 198293 | 6729 | 46481032 |
Complication of device insertion | 10.37 | 9.65 | 4 | 198297 | 4940 | 46482821 |
Bone lesion | 10.36 | 9.65 | 45 | 198256 | 4886 | 46482875 |
Stress fracture | 10.36 | 9.65 | 9 | 198292 | 7118 | 46480643 |
Monocyte count decreased | 10.35 | 9.65 | 23 | 198278 | 1734 | 46486027 |
Hyperlipidaemia | 10.35 | 9.65 | 42 | 198259 | 18497 | 46469264 |
Dysuria | 10.35 | 9.65 | 171 | 198130 | 27662 | 46460099 |
Pulmonary air leakage | 10.32 | 9.65 | 4 | 198297 | 23 | 46487738 |
Eczema | 10.30 | 9.65 | 48 | 198253 | 20352 | 46467409 |
Lipase decreased | 10.30 | 9.65 | 5 | 198296 | 53 | 46487708 |
Craniofacial deformity | 10.26 | 9.65 | 6 | 198295 | 95 | 46487666 |
Pulse absent | 10.24 | 9.65 | 45 | 198256 | 4911 | 46482850 |
Bronchitis | 10.17 | 9.65 | 358 | 197943 | 105621 | 46382140 |
Metastases to central nervous system | 10.16 | 9.65 | 82 | 198219 | 11139 | 46476622 |
Hair growth rate abnormal | 10.13 | 9.65 | 3 | 198298 | 6 | 46487755 |
Atelectasis neonatal | 10.13 | 9.65 | 3 | 198298 | 6 | 46487755 |
Stoma obstruction | 10.13 | 9.65 | 3 | 198298 | 6 | 46487755 |
Post procedural diarrhoea | 10.11 | 9.65 | 8 | 198293 | 212 | 46487549 |
Vena cava thrombosis | 10.11 | 9.65 | 26 | 198275 | 2153 | 46485608 |
Clostridial infection | 10.08 | 9.65 | 41 | 198260 | 4324 | 46483437 |
Productive cough | 10.08 | 9.65 | 153 | 198148 | 50562 | 46437199 |
Gastroenteropancreatic neuroendocrine tumour disease | 10.06 | 9.65 | 5 | 198296 | 56 | 46487705 |
Renal function test abnormal | 10.05 | 9.65 | 30 | 198271 | 2709 | 46485052 |
Hospitalisation | 10.05 | 9.65 | 346 | 197955 | 63039 | 46424722 |
Streptococcal sepsis | 10.04 | 9.65 | 22 | 198279 | 1643 | 46486118 |
Foetal hypokinesia | 10.00 | 9.65 | 11 | 198290 | 447 | 46487314 |
Portal vein thrombosis | 10 | 9.65 | 28 | 198273 | 2439 | 46485322 |
Intensive care | 9.95 | 9.65 | 8 | 198293 | 217 | 46487544 |
Cerebral haemorrhage | 9.95 | 9.65 | 75 | 198226 | 28296 | 46459465 |
Embolism | 9.94 | 9.65 | 58 | 198243 | 7080 | 46480681 |
Septic shock | 9.94 | 9.65 | 319 | 197982 | 57574 | 46430187 |
Anticholinergic syndrome | 9.93 | 9.65 | 23 | 198278 | 1783 | 46485978 |
Oral candidiasis | 9.89 | 9.65 | 116 | 198185 | 17416 | 46470345 |
Panniculitis | 9.85 | 9.65 | 6 | 198295 | 5698 | 46482063 |
Myopathy | 9.85 | 9.65 | 14 | 198287 | 8867 | 46478894 |
Anomalous pulmonary venous connection | 9.83 | 9.65 | 5 | 198296 | 59 | 46487702 |
Congenital anaemia | 9.82 | 9.65 | 3 | 198298 | 7 | 46487754 |
Postural orthostatic tachycardia syndrome | 9.78 | 9.65 | 13 | 198288 | 645 | 46487116 |
Abdominal pain upper | 9.77 | 9.65 | 730 | 197571 | 144575 | 46343186 |
Device malfunction | 9.73 | 9.65 | 27 | 198274 | 13347 | 46474414 |
Product use issue | 9.72 | 9.65 | 317 | 197984 | 94327 | 46393434 |
Aphasia | 9.71 | 9.65 | 173 | 198128 | 28394 | 46459367 |
Joint effusion | 9.66 | 9.65 | 23 | 198278 | 11972 | 46475789 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nausea | 564.19 | 10.29 | 2497 | 116336 | 294460 | 29539185 |
Febrile neutropenia | 482.57 | 10.29 | 1206 | 117627 | 105487 | 29728158 |
Vomiting | 454.55 | 10.29 | 1898 | 116935 | 217920 | 29615725 |
Drug ineffective | 321.97 | 10.29 | 536 | 118297 | 339851 | 29493794 |
Completed suicide | 275.47 | 10.29 | 35 | 118798 | 99457 | 29734188 |
Drug abuse | 258.82 | 10.29 | 17 | 118816 | 82055 | 29751590 |
Toxicity to various agents | 220.32 | 10.29 | 227 | 118606 | 176956 | 29656689 |
Dehydration | 202.89 | 10.29 | 998 | 117835 | 122541 | 29711104 |
Serotonin syndrome | 137.14 | 10.29 | 251 | 118582 | 17640 | 29816005 |
Left-to-right cardiac shunt | 134.94 | 10.29 | 32 | 118801 | 12 | 29833633 |
Neutropenia | 131.14 | 10.29 | 916 | 117917 | 127624 | 29706021 |
Myocardial infarction | 130.47 | 10.29 | 185 | 118648 | 125440 | 29708205 |
Pyrexia | 121.96 | 10.29 | 1738 | 117095 | 292751 | 29540894 |
Diarrhoea | 121.07 | 10.29 | 1927 | 116906 | 332176 | 29501469 |
Rheumatoid arthritis | 110.35 | 10.29 | 16 | 118817 | 41181 | 29792464 |
Abdominal pain | 102.03 | 10.29 | 901 | 117932 | 134753 | 29698892 |
Febrile bone marrow aplasia | 99.74 | 10.29 | 141 | 118692 | 7956 | 29825689 |
Rhabdomyolysis | 99.25 | 10.29 | 65 | 118768 | 63515 | 29770130 |
Chills | 97.01 | 10.29 | 553 | 118280 | 71785 | 29761860 |
Overdose | 96.98 | 10.29 | 115 | 118718 | 84222 | 29749423 |
Heart disease congenital | 96.70 | 10.29 | 61 | 118772 | 1197 | 29832448 |
Suicide attempt | 96.57 | 10.29 | 15 | 118818 | 36682 | 29796963 |
Disease progression | 92.69 | 10.29 | 588 | 118245 | 79286 | 29754359 |
Coronary artery disease | 91.93 | 10.29 | 41 | 118792 | 49671 | 29783974 |
Fatigue | 91.47 | 10.29 | 1781 | 117052 | 318892 | 29514753 |
Intentional overdose | 87.06 | 10.29 | 28 | 118805 | 41453 | 29792192 |
Failure to thrive | 85.83 | 10.29 | 131 | 118702 | 7923 | 29825722 |
Constipation | 84.37 | 10.29 | 749 | 118084 | 112157 | 29721488 |
Thrombocytopenia | 84.08 | 10.29 | 872 | 117961 | 136172 | 29697473 |
Mucosal inflammation | 83.76 | 10.29 | 289 | 118544 | 30205 | 29803440 |
Cytokine release syndrome | 82.06 | 10.29 | 144 | 118689 | 9789 | 29823856 |
Condition aggravated | 78.44 | 10.29 | 282 | 118551 | 137584 | 29696061 |
Otitis media chronic | 77.88 | 10.29 | 24 | 118809 | 64 | 29833581 |
Congenital anomaly | 77.17 | 10.29 | 54 | 118779 | 1268 | 29832377 |
Blood creatine phosphokinase increased | 76.72 | 10.29 | 39 | 118794 | 43809 | 29789836 |
Psoriasis | 74.08 | 10.29 | 38 | 118795 | 42468 | 29791177 |
Electrocardiogram QT prolonged | 70.08 | 10.29 | 305 | 118528 | 35530 | 29798115 |
Decreased appetite | 68.81 | 10.29 | 902 | 117931 | 149008 | 29684637 |
Flushing | 68.74 | 10.29 | 265 | 118568 | 29227 | 29804418 |
Small intestinal obstruction | 63.18 | 10.29 | 156 | 118677 | 13503 | 29820142 |
Drug resistance | 61.04 | 10.29 | 5 | 118828 | 20128 | 29813517 |
Treatment failure | 58.96 | 10.29 | 32 | 118801 | 34647 | 29798998 |
Tachycardia | 58.05 | 10.29 | 495 | 118338 | 73244 | 29760401 |
Hypoxia | 55.90 | 10.29 | 353 | 118480 | 47501 | 29786144 |
Torsade de pointes | 55.24 | 10.29 | 101 | 118732 | 7089 | 29826556 |
Erythema | 54.83 | 10.29 | 508 | 118325 | 76943 | 29756702 |
White blood cell count decreased | 54.69 | 10.29 | 541 | 118292 | 83406 | 29750239 |
Sepsis | 54.05 | 10.29 | 848 | 117985 | 145547 | 29688098 |
Therapeutic product effect incomplete | 53.59 | 10.29 | 34 | 118799 | 33800 | 29799845 |
Intentional product misuse | 50.70 | 10.29 | 38 | 118795 | 34629 | 29799016 |
Interstitial lung disease | 49.28 | 10.29 | 103 | 118730 | 60094 | 29773551 |
Arthralgia | 48.67 | 10.29 | 327 | 118506 | 135464 | 29698181 |
Hepatic function abnormal | 48.39 | 10.29 | 57 | 118776 | 41888 | 29791757 |
Aggression | 48.38 | 10.29 | 45 | 118788 | 36862 | 29796783 |
Plasma cell myeloma | 46.98 | 10.29 | 368 | 118465 | 53094 | 29780551 |
Myalgia | 44.77 | 10.29 | 155 | 118678 | 76512 | 29757133 |
Wrong technique in product usage process | 44.48 | 10.29 | 35 | 118798 | 31120 | 29802525 |
Musculoskeletal stiffness | 43.31 | 10.29 | 47 | 118786 | 35834 | 29797811 |
Aplasia | 42.08 | 10.29 | 65 | 118768 | 3972 | 29829673 |
Suicidal ideation | 41.74 | 10.29 | 49 | 118784 | 36065 | 29797580 |
Hospice care | 41.34 | 10.29 | 68 | 118765 | 4384 | 29829261 |
Pancytopenia | 41.16 | 10.29 | 517 | 118316 | 84535 | 29749110 |
Malignant neoplasm progression | 40.53 | 10.29 | 452 | 118381 | 71835 | 29761810 |
Malignant catatonia | 40.46 | 10.29 | 16 | 118817 | 106 | 29833539 |
Ventricular tachyarrhythmia | 40.40 | 10.29 | 21 | 118812 | 280 | 29833365 |
Right ventricular hypertrophy | 40.35 | 10.29 | 26 | 118807 | 530 | 29833115 |
Hypotension | 40.29 | 10.29 | 1061 | 117772 | 199504 | 29634141 |
Depression | 40.28 | 10.29 | 203 | 118630 | 90234 | 29743411 |
Asthma | 39.79 | 10.29 | 51 | 118782 | 36123 | 29797522 |
Hypophagia | 38.79 | 10.29 | 183 | 118650 | 22053 | 29811592 |
Right ventricular enlargement | 37.89 | 10.29 | 16 | 118817 | 128 | 29833517 |
Cardiac failure | 37.86 | 10.29 | 186 | 118647 | 83232 | 29750413 |
Cerebrovascular accident | 37.39 | 10.29 | 187 | 118646 | 83290 | 29750355 |
Intentional self-injury | 36.83 | 10.29 | 5 | 118828 | 13527 | 29820118 |
Neuropathy peripheral | 36.52 | 10.29 | 434 | 118399 | 70041 | 29763604 |
Diabetes mellitus | 36.52 | 10.29 | 69 | 118764 | 41796 | 29791849 |
Laevocardia | 36.27 | 10.29 | 8 | 118825 | 0 | 29833645 |
Platelet count decreased | 36.22 | 10.29 | 607 | 118226 | 105522 | 29728123 |
Fall | 36.19 | 10.29 | 506 | 118327 | 181366 | 29652279 |
Drug interaction | 35.32 | 10.29 | 568 | 118265 | 199000 | 29634645 |
Foetal exposure during pregnancy | 35.30 | 10.29 | 259 | 118574 | 36612 | 29797033 |
Right-to-left cardiac shunt | 35.11 | 10.29 | 10 | 118823 | 18 | 29833627 |
Melaena | 34.38 | 10.29 | 47 | 118786 | 32390 | 29801255 |
Drug dependence | 34.27 | 10.29 | 21 | 118812 | 21274 | 29812371 |
Psoriatic arthropathy | 34.21 | 10.29 | 10 | 118823 | 15751 | 29817894 |
Hypoplastic left heart syndrome | 33.78 | 10.29 | 17 | 118816 | 211 | 29833434 |
Asthenia | 33.67 | 10.29 | 1131 | 117702 | 220159 | 29613486 |
Renal impairment | 33.60 | 10.29 | 196 | 118637 | 83988 | 29749657 |
Angina pectoris | 33.10 | 10.29 | 41 | 118792 | 29477 | 29804168 |
Acute myocardial infarction | 32.98 | 10.29 | 104 | 118729 | 52835 | 29780810 |
Pulmonary artery stenosis congenital | 32.41 | 10.29 | 22 | 118811 | 491 | 29833154 |
Angioedema | 32.40 | 10.29 | 54 | 118779 | 34330 | 29799315 |
Stomatitis | 32.40 | 10.29 | 256 | 118577 | 37023 | 29796622 |
Encephalopathy | 31.85 | 10.29 | 228 | 118605 | 31977 | 29801668 |
Inappropriate schedule of product administration | 31.65 | 10.29 | 69 | 118764 | 39659 | 29793986 |
Eustachian tube dysfunction | 31.59 | 10.29 | 11 | 118822 | 48 | 29833597 |
Therapeutic response decreased | 31.54 | 10.29 | 30 | 118803 | 24319 | 29809326 |
Atrial septal defect | 31.48 | 10.29 | 77 | 118756 | 6624 | 29827021 |
Hypersensitivity | 31.27 | 10.29 | 340 | 118493 | 53688 | 29779957 |
Weight increased | 31.20 | 10.29 | 172 | 118661 | 74741 | 29758904 |
Hypokalaemia | 30.99 | 10.29 | 320 | 118513 | 49872 | 29783773 |
Therapeutic product effect decreased | 30.94 | 10.29 | 42 | 118791 | 29034 | 29804611 |
Neutrophil count decreased | 30.80 | 10.29 | 280 | 118553 | 42174 | 29791471 |
Poor feeding infant | 30.61 | 10.29 | 19 | 118814 | 362 | 29833283 |
Erectile dysfunction | 30.34 | 10.29 | 17 | 118816 | 18085 | 29815560 |
Otitis media acute | 30.07 | 10.29 | 19 | 118814 | 374 | 29833271 |
Cardiac failure congestive | 29.84 | 10.29 | 204 | 118629 | 84203 | 29749442 |
Blood cholesterol increased | 29.82 | 10.29 | 15 | 118818 | 16955 | 29816690 |
Full blood count decreased | 29.37 | 10.29 | 132 | 118701 | 15585 | 29818060 |
Pneumonia | 29.31 | 10.29 | 1613 | 117220 | 332693 | 29500952 |
Injection site pain | 29.12 | 10.29 | 47 | 118786 | 30263 | 29803382 |
Neoplasm progression | 29.04 | 10.29 | 145 | 118688 | 17878 | 29815767 |
Developmental delay | 28.94 | 10.29 | 39 | 118794 | 2102 | 29831543 |
Colitis | 28.65 | 10.29 | 215 | 118618 | 30605 | 29803040 |
Bacteraemia | 28.57 | 10.29 | 130 | 118703 | 15430 | 29818215 |
Negative pressure pulmonary oedema | 28.41 | 10.29 | 15 | 118818 | 207 | 29833438 |
Angina unstable | 28.25 | 10.29 | 7 | 118826 | 12303 | 29821342 |
Cerebral infarction | 28.16 | 10.29 | 38 | 118795 | 26335 | 29807310 |
Hallucination, auditory | 28.16 | 10.29 | 3 | 118830 | 9786 | 29823859 |
Diabetes mellitus inadequate control | 27.88 | 10.29 | 8 | 118825 | 12754 | 29820891 |
Atelectasis | 27.55 | 10.29 | 132 | 118701 | 16006 | 29817639 |
Infusion related reaction | 27.15 | 10.29 | 263 | 118570 | 40301 | 29793344 |
Oral pain | 27.09 | 10.29 | 91 | 118742 | 9378 | 29824267 |
Coma | 26.23 | 10.29 | 78 | 118755 | 40371 | 29793274 |
Sepsis neonatal | 26.08 | 10.29 | 15 | 118818 | 247 | 29833398 |
Deep vein thrombosis | 26.01 | 10.29 | 360 | 118473 | 60141 | 29773504 |
Impaired gastric emptying | 25.86 | 10.29 | 46 | 118787 | 3160 | 29830485 |
Synovitis | 25.73 | 10.29 | 4 | 118829 | 9779 | 29823866 |
Product dose omission issue | 25.64 | 10.29 | 236 | 118597 | 91395 | 29742250 |
Mental status changes | 25.61 | 10.29 | 242 | 118591 | 36837 | 29796808 |
Schizophrenia | 25.46 | 10.29 | 3 | 118830 | 9045 | 29824600 |
Pleural effusion | 25.39 | 10.29 | 424 | 118409 | 73642 | 29760003 |
Anaphylactic reaction | 25.33 | 10.29 | 194 | 118639 | 27788 | 29805857 |
Chemotherapeutic drug level increased | 25.31 | 10.29 | 14 | 118819 | 213 | 29833432 |
Blood triglycerides increased | 25.22 | 10.29 | 12 | 118821 | 14005 | 29819640 |
Oxygen saturation immeasurable | 24.86 | 10.29 | 9 | 118824 | 45 | 29833600 |
Adenoidal hypertrophy | 24.84 | 10.29 | 11 | 118822 | 100 | 29833545 |
Hypoglycaemia | 24.69 | 10.29 | 111 | 118722 | 50870 | 29782775 |
Dry skin | 24.59 | 10.29 | 163 | 118670 | 22291 | 29811354 |
Hyperbilirubinaemia | 24.32 | 10.29 | 132 | 118701 | 16810 | 29816835 |
Blood pressure measurement | 24.05 | 10.29 | 12 | 118821 | 146 | 29833499 |
Malnutrition | 23.57 | 10.29 | 99 | 118734 | 11350 | 29822295 |
Multiple congenital abnormalities | 23.33 | 10.29 | 18 | 118815 | 493 | 29833152 |
Oxygen saturation decreased | 23.15 | 10.29 | 269 | 118564 | 43171 | 29790474 |
Univentricular heart | 23.07 | 10.29 | 6 | 118827 | 6 | 29833639 |
Appendicolith | 23.01 | 10.29 | 23 | 118810 | 896 | 29832749 |
Psychotic disorder | 22.97 | 10.29 | 31 | 118802 | 21484 | 29812161 |
Atelectasis neonatal | 22.67 | 10.29 | 5 | 118828 | 0 | 29833645 |
Cleft palate | 22.63 | 10.29 | 19 | 118814 | 589 | 29833056 |
Coronary artery occlusion | 22.58 | 10.29 | 8 | 118825 | 11149 | 29822496 |
Type 2 diabetes mellitus | 22.53 | 10.29 | 13 | 118820 | 13609 | 29820036 |
Oropharyngeal discomfort | 22.47 | 10.29 | 29 | 118804 | 1498 | 29832147 |
Product substitution issue | 22.46 | 10.29 | 6 | 118827 | 10029 | 29823616 |
Tumour lysis syndrome | 22.44 | 10.29 | 106 | 118727 | 12779 | 29820866 |
Labelled drug-drug interaction medication error | 22.30 | 10.29 | 7 | 118826 | 10531 | 29823114 |
Aplastic anaemia | 22.13 | 10.29 | 60 | 118773 | 5496 | 29828149 |
Palmar erythema | 22.09 | 10.29 | 13 | 118820 | 224 | 29833421 |
Altered state of consciousness | 21.99 | 10.29 | 28 | 118805 | 19891 | 29813754 |
Abnormal behaviour | 21.67 | 10.29 | 43 | 118790 | 25580 | 29808065 |
Testicular germ cell cancer metastatic | 21.64 | 10.29 | 9 | 118824 | 69 | 29833576 |
Periorbital swelling | 21.62 | 10.29 | 12 | 118821 | 184 | 29833461 |
Cytomegalovirus infection | 21.55 | 10.29 | 38 | 118795 | 23636 | 29810009 |
Painful respiration | 21.35 | 10.29 | 26 | 118807 | 1266 | 29832379 |
Right ventricular dilatation | 21.24 | 10.29 | 17 | 118816 | 492 | 29833153 |
Hyperthermia malignant | 21.21 | 10.29 | 31 | 118802 | 1803 | 29831842 |
Right aortic arch | 21.20 | 10.29 | 7 | 118826 | 25 | 29833620 |
Endocardial fibroelastosis | 21.00 | 10.29 | 6 | 118827 | 11 | 29833634 |
Tubulointerstitial nephritis | 20.97 | 10.29 | 24 | 118809 | 17867 | 29815778 |
Bradycardia | 20.45 | 10.29 | 164 | 118669 | 65362 | 29768283 |
Feeling hot | 20.40 | 10.29 | 118 | 118715 | 15386 | 29818259 |
Klebsiella bacteraemia | 20.34 | 10.29 | 23 | 118810 | 1034 | 29832611 |
Poisoning | 20.09 | 10.29 | 10 | 118823 | 11372 | 29822273 |
Coarctation of the aorta | 20.05 | 10.29 | 16 | 118817 | 461 | 29833184 |
Joint swelling | 19.97 | 10.29 | 107 | 118726 | 46839 | 29786806 |
Incorrect dose administered | 19.90 | 10.29 | 62 | 118771 | 31624 | 29802021 |
Impetigo | 19.89 | 10.29 | 20 | 118813 | 785 | 29832860 |
Respiratory distress | 19.77 | 10.29 | 209 | 118624 | 32763 | 29800882 |
Hypomagnesaemia | 19.71 | 10.29 | 123 | 118710 | 16475 | 29817170 |
Lactic acidosis | 19.66 | 10.29 | 61 | 118772 | 31152 | 29802493 |
Prostate cancer | 19.59 | 10.29 | 41 | 118792 | 23916 | 29809729 |
Tendonitis | 19.58 | 10.29 | 4 | 118829 | 8032 | 29825613 |
Hypoplastic right heart syndrome | 19.47 | 10.29 | 6 | 118827 | 16 | 29833629 |
Dermatitis diaper | 19.43 | 10.29 | 13 | 118820 | 283 | 29833362 |
Clonus | 19.25 | 10.29 | 35 | 118798 | 2446 | 29831199 |
Infusion site urticaria | 19.24 | 10.29 | 9 | 118824 | 94 | 29833551 |
Treatment noncompliance | 19.18 | 10.29 | 45 | 118788 | 25208 | 29808437 |
Death | 18.96 | 10.29 | 1654 | 117179 | 355629 | 29478016 |
Somnolence | 18.92 | 10.29 | 270 | 118563 | 96493 | 29737152 |
Liver disorder | 18.78 | 10.29 | 58 | 118775 | 29664 | 29803981 |
Laryngeal discomfort | 18.69 | 10.29 | 10 | 118823 | 142 | 29833503 |
C-reactive protein increased | 18.54 | 10.29 | 99 | 118734 | 43374 | 29790271 |
Fear | 18.38 | 10.29 | 10 | 118823 | 10815 | 29822830 |
Feeding disorder | 18.21 | 10.29 | 58 | 118775 | 5813 | 29827832 |
Gastrointestinal malformation | 18.14 | 10.29 | 7 | 118826 | 43 | 29833602 |
Poor weight gain neonatal | 18.14 | 10.29 | 4 | 118829 | 0 | 29833645 |
Osteoarthritis | 18.05 | 10.29 | 28 | 118805 | 18321 | 29815324 |
Nasopharyngitis | 18.04 | 10.29 | 148 | 118685 | 58701 | 29774944 |
Platelet transfusion | 18.00 | 10.29 | 21 | 118812 | 977 | 29832668 |
Necrotising retinitis | 17.89 | 10.29 | 18 | 118815 | 707 | 29832938 |
Road traffic accident | 17.82 | 10.29 | 25 | 118808 | 17046 | 29816599 |
Immune-mediated hepatitis | 17.70 | 10.29 | 22 | 118811 | 1094 | 29832551 |
Change of bowel habit | 17.68 | 10.29 | 21 | 118812 | 996 | 29832649 |
Eosinophil count increased | 17.64 | 10.29 | 4 | 118829 | 7469 | 29826176 |
Immune reconstitution inflammatory syndrome | 17.63 | 10.29 | 7 | 118826 | 9094 | 29824551 |
Walking aid user | 17.52 | 10.29 | 25 | 118808 | 1422 | 29832223 |
Laryngospasm | 17.45 | 10.29 | 24 | 118809 | 1319 | 29832326 |
Clostridium difficile colitis | 17.34 | 10.29 | 98 | 118735 | 12670 | 29820975 |
Tachypnoea | 17.26 | 10.29 | 110 | 118723 | 14842 | 29818803 |
Disturbance in attention | 17.16 | 10.29 | 39 | 118794 | 22090 | 29811555 |
Drug ineffective for unapproved indication | 17.13 | 10.29 | 11 | 118822 | 10869 | 29822776 |
Faeces discoloured | 17.12 | 10.29 | 18 | 118815 | 13928 | 29819717 |
Gait disturbance | 17.07 | 10.29 | 202 | 118631 | 74575 | 29759070 |
Blood pressure fluctuation | 16.94 | 10.29 | 27 | 118806 | 17476 | 29816169 |
Accidental overdose | 16.94 | 10.29 | 29 | 118804 | 18246 | 29815399 |
Gynaecomastia | 16.88 | 10.29 | 6 | 118827 | 8345 | 29825300 |
Upper respiratory tract infection | 16.87 | 10.29 | 175 | 118658 | 27301 | 29806344 |
Electrocardiogram T wave biphasic | 16.80 | 10.29 | 7 | 118826 | 54 | 29833591 |
Congenital aortic stenosis | 16.74 | 10.29 | 8 | 118825 | 88 | 29833557 |
Fixed eruption | 16.67 | 10.29 | 22 | 118811 | 1162 | 29832483 |
Perihepatic abscess | 16.66 | 10.29 | 8 | 118825 | 89 | 29833556 |
Unresponsive to stimuli | 16.56 | 10.29 | 169 | 118664 | 26250 | 29807395 |
Enteritis | 16.54 | 10.29 | 61 | 118772 | 6584 | 29827061 |
Urine sodium decreased | 16.51 | 10.29 | 10 | 118823 | 182 | 29833463 |
Large intestinal obstruction | 16.42 | 10.29 | 24 | 118809 | 1396 | 29832249 |
Croup infectious | 16.14 | 10.29 | 11 | 118822 | 247 | 29833398 |
Pulmonary embolism | 16.11 | 10.29 | 415 | 118418 | 77720 | 29755925 |
Sinus tachycardia | 16.05 | 10.29 | 111 | 118722 | 15393 | 29818252 |
Ventricular fibrillation | 16.04 | 10.29 | 109 | 118724 | 15029 | 29818616 |
Pulse absent | 16.01 | 10.29 | 53 | 118780 | 5420 | 29828225 |
Pulmonary oedema neonatal | 15.91 | 10.29 | 4 | 118829 | 3 | 29833642 |
Loss of personal independence in daily activities | 15.86 | 10.29 | 39 | 118794 | 21496 | 29812149 |
Cleft lip | 15.80 | 10.29 | 12 | 118821 | 321 | 29833324 |
Glycosylated haemoglobin increased | 15.78 | 10.29 | 9 | 118824 | 9482 | 29824163 |
Blood glucose increased | 15.72 | 10.29 | 162 | 118671 | 61368 | 29772277 |
Cyanosis neonatal | 15.44 | 10.29 | 11 | 118822 | 266 | 29833379 |
Insomnia | 15.37 | 10.29 | 269 | 118564 | 93067 | 29740578 |
Septic shock | 15.28 | 10.29 | 345 | 118488 | 63262 | 29770383 |
Myocardial oedema | 15.23 | 10.29 | 7 | 118826 | 70 | 29833575 |
Bone marrow transplant | 15.22 | 10.29 | 19 | 118814 | 949 | 29832696 |
Electrocardiogram QT shortened | 15.19 | 10.29 | 9 | 118824 | 157 | 29833488 |
Osteoporosis | 15.19 | 10.29 | 12 | 118821 | 10651 | 29822994 |
Hepatitis C | 15.16 | 10.29 | 18 | 118815 | 13187 | 29820458 |
Velopharyngeal incompetence | 15.11 | 10.29 | 5 | 118828 | 18 | 29833627 |
Paranoia | 15.11 | 10.29 | 11 | 118822 | 10177 | 29823468 |
Stridor | 15.07 | 10.29 | 30 | 118803 | 2244 | 29831401 |
Pain in extremity | 15.01 | 10.29 | 328 | 118505 | 109893 | 29723752 |
Hyperaemia | 14.99 | 10.29 | 19 | 118814 | 964 | 29832681 |
Transplant rejection | 14.92 | 10.29 | 9 | 118824 | 9197 | 29824448 |
Right ventricle outflow tract obstruction | 14.91 | 10.29 | 4 | 118829 | 5 | 29833640 |
Procedural nausea | 14.81 | 10.29 | 7 | 118826 | 75 | 29833570 |
Hyperkalaemia | 14.80 | 10.29 | 179 | 118654 | 65831 | 29767814 |
Erythropenia | 14.74 | 10.29 | 10 | 118823 | 223 | 29833422 |
Oral candidiasis | 14.39 | 10.29 | 84 | 118749 | 10987 | 29822658 |
Cataract | 14.23 | 10.29 | 42 | 118791 | 21793 | 29811852 |
Arteriosclerosis coronary artery | 14.20 | 10.29 | 14 | 118819 | 11162 | 29822483 |
International normalised ratio increased | 14.20 | 10.29 | 121 | 118712 | 47618 | 29786027 |
Atrioventricular block complete | 14.15 | 10.29 | 8 | 118825 | 8469 | 29825176 |
Chronic obstructive pulmonary disease | 14.14 | 10.29 | 116 | 118717 | 46010 | 29787635 |
Congenital torticollis | 14.12 | 10.29 | 4 | 118829 | 7 | 29833638 |
Depressed mood | 14.04 | 10.29 | 29 | 118804 | 17000 | 29816645 |
Cardiac murmur | 13.99 | 10.29 | 59 | 118774 | 6775 | 29826870 |
Right atrial enlargement | 13.96 | 10.29 | 10 | 118823 | 244 | 29833401 |
Pathogen resistance | 13.94 | 10.29 | 8 | 118825 | 8402 | 29825243 |
Cardiac ventricular disorder | 13.94 | 10.29 | 9 | 118824 | 184 | 29833461 |
Visual acuity reduced | 13.92 | 10.29 | 26 | 118807 | 15820 | 29817825 |
Intestinal ischaemia | 13.70 | 10.29 | 59 | 118774 | 6838 | 29826807 |
Hypoalbuminaemia | 13.68 | 10.29 | 83 | 118750 | 11009 | 29822636 |
Dyslipidaemia | 13.65 | 10.29 | 3 | 118830 | 5724 | 29827921 |
Adenoiditis | 13.60 | 10.29 | 3 | 118830 | 0 | 29833645 |
Cardiomyopathy neonatal | 13.60 | 10.29 | 3 | 118830 | 0 | 29833645 |
Cardiac malposition | 13.60 | 10.29 | 3 | 118830 | 0 | 29833645 |
Cystic fibrosis pancreatic | 13.60 | 10.29 | 3 | 118830 | 0 | 29833645 |
Hemiplegic migraine | 13.60 | 10.29 | 3 | 118830 | 0 | 29833645 |
Hyponatraemia | 13.58 | 10.29 | 356 | 118477 | 66846 | 29766799 |
Anomalous pulmonary venous connection | 13.56 | 10.29 | 7 | 118826 | 92 | 29833553 |
Capillary leak syndrome | 13.50 | 10.29 | 24 | 118809 | 1648 | 29831997 |
Locked-in syndrome | 13.48 | 10.29 | 10 | 118823 | 258 | 29833387 |
Underdose | 13.47 | 10.29 | 17 | 118816 | 12124 | 29821521 |
Thrombosis | 13.46 | 10.29 | 239 | 118594 | 41992 | 29791653 |
Hallucination | 13.43 | 10.29 | 127 | 118706 | 48932 | 29784713 |
Aorta hypoplasia | 13.42 | 10.29 | 7 | 118826 | 94 | 29833551 |
Neurotoxicity | 13.42 | 10.29 | 94 | 118739 | 13088 | 29820557 |
Patent ductus arteriosus | 13.41 | 10.29 | 35 | 118798 | 3134 | 29830511 |
Palmar-plantar erythrodysaesthesia syndrome | 13.40 | 10.29 | 103 | 118730 | 14767 | 29818878 |
Atrial fibrillation | 13.32 | 10.29 | 540 | 118293 | 107584 | 29726061 |
Gastrointestinal haemorrhage | 13.26 | 10.29 | 242 | 118591 | 83204 | 29750441 |
Speech sound disorder | 13.23 | 10.29 | 6 | 118827 | 58 | 29833587 |
Inflammation | 13.20 | 10.29 | 44 | 118789 | 21982 | 29811663 |
Extravasation | 13.19 | 10.29 | 25 | 118808 | 1803 | 29831842 |
Trismus | 13.11 | 10.29 | 29 | 118804 | 2336 | 29831309 |
Product quality issue | 13.06 | 10.29 | 35 | 118798 | 18739 | 29814906 |
Obesity | 13.00 | 10.29 | 9 | 118824 | 8546 | 29825099 |
Subileus | 12.97 | 10.29 | 34 | 118799 | 3053 | 29830592 |
Tuberculosis | 12.95 | 10.29 | 8 | 118825 | 8069 | 29825576 |
Cardiac arrest | 12.93 | 10.29 | 470 | 118363 | 92380 | 29741265 |
Vitamin B1 deficiency | 12.80 | 10.29 | 9 | 118824 | 213 | 29833432 |
Ventricular hypoplasia | 12.80 | 10.29 | 6 | 118827 | 63 | 29833582 |
Supraventricular tachycardia | 12.75 | 10.29 | 77 | 118756 | 10195 | 29823450 |
Fracture | 12.69 | 10.29 | 4 | 118829 | 6002 | 29827643 |
Leukopenia | 12.68 | 10.29 | 302 | 118531 | 55857 | 29777788 |
Sexual dysfunction | 12.68 | 10.29 | 4 | 118829 | 5997 | 29827648 |
Kidney transplant rejection | 12.66 | 10.29 | 7 | 118826 | 7502 | 29826143 |
Myopathy | 12.62 | 10.29 | 14 | 118819 | 10572 | 29823073 |
Tympanic membrane perforation | 12.51 | 10.29 | 9 | 118824 | 221 | 29833424 |
Therapy interrupted | 12.49 | 10.29 | 43 | 118790 | 4486 | 29829159 |
Accidental exposure to product | 12.48 | 10.29 | 13 | 118820 | 10102 | 29823543 |
Parainfluenzae virus infection | 12.46 | 10.29 | 26 | 118807 | 2012 | 29831633 |
Phimosis | 12.37 | 10.29 | 14 | 118819 | 630 | 29833015 |
Ventricular tachycardia | 12.37 | 10.29 | 147 | 118686 | 23715 | 29809930 |
Poisoning deliberate | 12.36 | 10.29 | 4 | 118829 | 5900 | 29827745 |
Mobility decreased | 12.35 | 10.29 | 57 | 118776 | 25942 | 29807703 |
Injection site haemorrhage | 12.29 | 10.29 | 8 | 118825 | 7847 | 29825798 |
Catheter site pain | 12.28 | 10.29 | 18 | 118815 | 1050 | 29832595 |
Anaemia | 12.28 | 10.29 | 971 | 117862 | 207021 | 29626624 |
Dementia | 12.27 | 10.29 | 19 | 118814 | 12442 | 29821203 |
Congenital genitourinary abnormality | 12.17 | 10.29 | 4 | 118829 | 14 | 29833631 |
Neonatal tachycardia | 12.17 | 10.29 | 4 | 118829 | 14 | 29833631 |
Oesophageal irritation | 12.17 | 10.29 | 6 | 118827 | 71 | 29833574 |
Seminoma | 12.17 | 10.29 | 9 | 118824 | 231 | 29833414 |
Joint range of motion decreased | 12.16 | 10.29 | 4 | 118829 | 5841 | 29827804 |
Osteonecrosis | 12.06 | 10.29 | 29 | 118804 | 16106 | 29817539 |
Hyperlipidaemia | 12.05 | 10.29 | 23 | 118810 | 13884 | 29819761 |
Product complaint | 12.03 | 10.29 | 4 | 118829 | 5802 | 29827843 |
Neonatal tachypnoea | 12.03 | 10.29 | 7 | 118826 | 118 | 29833527 |
Atrioventricular septal defect | 12.03 | 10.29 | 6 | 118827 | 73 | 29833572 |
Neutropenic colitis | 11.97 | 10.29 | 27 | 118806 | 2203 | 29831442 |
Parkinsonism | 11.93 | 10.29 | 7 | 118826 | 7262 | 29826383 |
Respiratory depression | 11.85 | 10.29 | 17 | 118816 | 11486 | 29822159 |
Hot flush | 11.77 | 10.29 | 99 | 118734 | 14581 | 29819064 |
Congenital hypothyroidism | 11.76 | 10.29 | 4 | 118829 | 16 | 29833629 |
Congenital pulmonary artery anomaly | 11.76 | 10.29 | 4 | 118829 | 16 | 29833629 |
Skin ulcer | 11.75 | 10.29 | 37 | 118796 | 18812 | 29814833 |
Cytokine storm | 11.74 | 10.29 | 13 | 118820 | 571 | 29833074 |
Ageusia | 11.68 | 10.29 | 68 | 118765 | 8885 | 29824760 |
Dysgeusia | 11.65 | 10.29 | 150 | 118683 | 24651 | 29808994 |
Epilepsy | 11.61 | 10.29 | 41 | 118792 | 20128 | 29813517 |
Hyperbilirubinaemia neonatal | 11.59 | 10.29 | 14 | 118819 | 676 | 29832969 |
Ischaemic stroke | 11.58 | 10.29 | 30 | 118803 | 16245 | 29817400 |
Chest injury | 11.56 | 10.29 | 20 | 118813 | 1344 | 29832301 |
Urinary tract infection neonatal | 11.53 | 10.29 | 3 | 118830 | 3 | 29833642 |
Anaesthetic complication neurological | 11.51 | 10.29 | 10 | 118823 | 325 | 29833320 |
Glomerular filtration rate decreased | 11.50 | 10.29 | 17 | 118816 | 11345 | 29822300 |
Knee arthroplasty | 11.46 | 10.29 | 4 | 118829 | 5626 | 29828019 |
Sleep disorder | 11.43 | 10.29 | 54 | 118779 | 24425 | 29809220 |
Product administration error | 11.42 | 10.29 | 25 | 118808 | 14352 | 29819293 |
Photosensitivity reaction | 11.36 | 10.29 | 13 | 118820 | 9681 | 29823964 |
Cerebral haemorrhage | 11.35 | 10.29 | 80 | 118753 | 32807 | 29800838 |
Nightmare | 11.34 | 10.29 | 19 | 118814 | 12057 | 29821588 |
Blood culture positive | 11.29 | 10.29 | 44 | 118789 | 4875 | 29828770 |
Drug eruption | 11.21 | 10.29 | 34 | 118799 | 17492 | 29816153 |
Memory impairment | 11.16 | 10.29 | 94 | 118739 | 37080 | 29796565 |
No reaction on previous exposure to drug | 11.10 | 10.29 | 6 | 118827 | 87 | 29833558 |
Mitral valve atresia | 11.08 | 10.29 | 3 | 118830 | 4 | 29833641 |
Ventricular septal defect | 11.07 | 10.29 | 35 | 118798 | 3494 | 29830151 |
Enterovirus test positive | 11.05 | 10.29 | 5 | 118828 | 48 | 29833597 |
Diaphragmatic rupture | 11.05 | 10.29 | 4 | 118829 | 20 | 29833625 |
Vasospasm | 11.01 | 10.29 | 10 | 118823 | 345 | 29833300 |
Congenital pulmonary hypertension | 10.97 | 10.29 | 5 | 118828 | 49 | 29833596 |
Infusion site pain | 10.94 | 10.29 | 29 | 118804 | 2621 | 29831024 |
Anger | 10.91 | 10.29 | 17 | 118816 | 11103 | 29822542 |
Clostridium difficile infection | 10.89 | 10.29 | 103 | 118730 | 15680 | 29817965 |
Device issue | 10.88 | 10.29 | 9 | 118824 | 7807 | 29825838 |
Hypoperfusion | 10.83 | 10.29 | 17 | 118816 | 1053 | 29832592 |
Pseudomonal bacteraemia | 10.82 | 10.29 | 15 | 118818 | 831 | 29832814 |
Coronary artery stenosis | 10.81 | 10.29 | 12 | 118821 | 9058 | 29824587 |
Micrognathia | 10.80 | 10.29 | 9 | 118824 | 276 | 29833369 |
Therapeutic product effect prolonged | 10.77 | 10.29 | 9 | 118824 | 277 | 29833368 |
Back pain | 10.77 | 10.29 | 504 | 118329 | 102092 | 29731553 |
Device related infection | 10.74 | 10.29 | 109 | 118724 | 16906 | 29816739 |
Hypospadias | 10.74 | 10.29 | 29 | 118804 | 2650 | 29830995 |
Bronchial hyperreactivity | 10.72 | 10.29 | 18 | 118815 | 1180 | 29832465 |
Arthritis | 10.72 | 10.29 | 55 | 118778 | 24346 | 29809299 |
Cold type haemolytic anaemia | 10.69 | 10.29 | 6 | 118827 | 94 | 29833551 |
Eye pain | 10.66 | 10.29 | 19 | 118814 | 11770 | 29821875 |
Pseudomonal sepsis | 10.58 | 10.29 | 31 | 118802 | 2969 | 29830676 |
Alcohol abuse | 10.56 | 10.29 | 4 | 118829 | 5349 | 29828296 |
Biliary tract infection | 10.53 | 10.29 | 11 | 118822 | 452 | 29833193 |
Haematoma | 10.52 | 10.29 | 54 | 118779 | 23899 | 29809746 |
Jaundice neonatal | 10.52 | 10.29 | 17 | 118816 | 1080 | 29832565 |
Depressed level of consciousness | 10.44 | 10.29 | 99 | 118734 | 38123 | 29795522 |
Taste disorder | 10.43 | 10.29 | 34 | 118799 | 3449 | 29830196 |
Tryptase increased | 10.41 | 10.29 | 8 | 118825 | 218 | 29833427 |
Inflammatory pain | 10.38 | 10.29 | 5 | 118828 | 56 | 29833589 |
Antithrombin III deficiency | 10.37 | 10.29 | 6 | 118827 | 100 | 29833545 |
Abdominal compartment syndrome | 10.35 | 10.29 | 15 | 118818 | 866 | 29832779 |
Foreign body embolism | 10.33 | 10.29 | 3 | 118830 | 6 | 29833639 |
Neutrophilic panniculitis | 10.31 | 10.29 | 4 | 118829 | 25 | 29833620 |
Appendicitis | 10.30 | 10.29 | 50 | 118783 | 6094 | 29827551 |
Middle insomnia | 10.30 | 10.29 | 5 | 118828 | 5768 | 29827877 |
Source | Code | Description |
---|---|---|
ATC | A04AA01 | ALIMENTARY TRACT AND METABOLISM ANTIEMETICS AND ANTINAUSEANTS ANTIEMETICS AND ANTINAUSEANTS Serotonin (5HT3) antagonists |
FDA MoA | N0000175817 | Serotonin 3 Receptor Antagonists |
FDA EPC | N0000175818 | Serotonin-3 Receptor Antagonist |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D000982 | Antipruritics |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Chemotherapy-induced nausea and vomiting | indication | 236084000 | |
Prevention of Radiation-Induced Nausea and Vomiting | indication | ||
Prevention of Post-Operative Nausea and Vomiting | indication | ||
Excessive vomiting in pregnancy | off-label use | 14094001 | |
Torsades de pointes | contraindication | 31722008 | |
Hepatic failure | contraindication | 59927004 | |
Extrapyramidal disease | contraindication | 76349003 | |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Congenital long QT syndrome | contraindication | 442917000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.13 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 7.80 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.34 | DRUG MATRIX | |||||
Solute carrier family 22 member 3 | Transporter | IC50 | 4.76 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.69 | CHEMBL | |||||
Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 4.34 | CHEMBL | |||||
Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 6.80 | CHEMBL | |||||
Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 7.52 | CHEMBL | |||||
Solute carrier family 22 member 2 | Transporter | IC50 | 5.77 | CHEMBL | |||||
5-hydroxytryptamine receptor 3B | Ion channel | Ki | 8.30 | CHEMBL | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.68 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.09 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 9.11 | CHEMBL | |||||
Serotonin 2 (5-HT2) receptor | GPCR | Ki | 5 | CHEMBL | |||||
Serotonin 3 receptor (5HT3) | Ion channel | Ki | 7.92 | CHEMBL | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.43 | CHEMBL | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 4.70 | CHEMBL | |||||
Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 9.11 | CHEMBL | |||||
Gastrin/cholecystokinin type B receptor | GPCR | Ki | 6.17 | CHEMBL | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5 | CHEMBL | |||||
Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | IC50 | 4.60 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 5.54 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 5.92 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.17 | CHEMBL |
ID | Source |
---|---|
4019865 | VUID |
N0000147951 | NUI |
D00456 | KEGG_DRUG |
103639-04-9 | SECONDARY_CAS_RN |
4019563 | VANDF |
4019865 | VANDF |
C0733434 | UMLSCUI |
CHEBI:7773 | CHEBI |
S87 | PDB_CHEM_ID |
CHEMBL46 | ChEMBL_ID |
CHEMBL1201111 | ChEMBL_ID |
CHEMBL3186492 | ChEMBL_ID |
CHEMBL428411 | ChEMBL_ID |
CHEMBL399705 | ChEMBL_ID |
D017294 | MESH_DESCRIPTOR_UI |
DB00904 | DRUGBANK_ID |
2290 | IUPHAR_LIGAND_ID |
5965 | INN_ID |
4AF302ESOS | UNII |
59774 | PUBCHEM_CID |
203148 | RXNORM |
27290 | MMSL |
5202 | MMSL |
90631 | MMSL |
d00867 | MMSL |
003568 | NDDF |
004807 | NDDF |
108418007 | SNOMEDCT_US |
108419004 | SNOMEDCT_US |
372487007 | SNOMEDCT_US |
830157000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ondansetron Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0064 | SOLUTION | 4 mg | ORAL | ANDA | 26 sections |
ZOFRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0675 | TABLET, FILM COATED | 4 mg | ORAL | NDA | 30 sections |
ZOFRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0676 | TABLET, FILM COATED | 8 mg | ORAL | NDA | 30 sections |
Ondansetron Hydrochloride and Dextrose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9771 | INJECTION, SOLUTION | 32 mg | INTRAVENOUS | ANDA | 24 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9890 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9891 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7732 | TABLET, ORALLY DISINTEGRATING | 4 mg | ORAL | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7734 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4755 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4759 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ondansetron Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1726 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8185 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6078 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6079 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6080 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 26 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6551 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 26 sections |
ondansetron hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6552 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7073 | SOLUTION | 4 mg | ORAL | ANDA | 26 sections |
Ondansetron Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-575 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 22 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11819-365 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 11819-371 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 27 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-545 | TABLET, ORALLY DISINTEGRATING | 4 mg | ORAL | ANDA | 12 sections |
Ondansetron | Human Prescription Drug Label | 1 | 16714-159 | TABLET, FILM COATED | 4 mg | ORAL | ANDA | 26 sections |
Ondansetron | Human Prescription Drug Label | 1 | 16714-160 | TABLET, FILM COATED | 8 mg | ORAL | ANDA | 26 sections |
Ondansetron | Human Prescription Drug Label | 1 | 16714-200 | TABLET, ORALLY DISINTEGRATING | 4 mg | ORAL | ANDA | 26 sections |
Ondansetron | Human Prescription Drug Label | 1 | 16714-201 | TABLET, ORALLY DISINTEGRATING | 8 mg | ORAL | ANDA | 26 sections |
Ondansetron | Human Prescription Drug Label | 1 | 16714-671 | SOLUTION | 4 mg | ORAL | ANDA | 26 sections |
ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-297 | INJECTION | 2 mg | INTRAVENOUS | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-298 | INJECTION | 2 mg | INTRAVENOUS | ANDA | 26 sections |
Ondansetron | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0555 | SOLUTION | 4 mg | ORAL | ANDA | 26 sections |