isoxsuprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1510 395-28-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • duvadilan
  • isoxuprine
  • isoxsuprine
  • isoxsuprine hydrochloride
  • vadosilan
  • dilavase
  • isoxsuprine HCl
A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
  • Molecular weight: 301.39
  • Formula: C18H23NO3
  • CLOGP: 2.62
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 61.72
  • ALOGS: -3.77
  • ROTB: 7

Drug dosage:

DoseUnitRoute
60 mg O
60 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 2.20 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 22
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AA01 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
2-amino-1-phenylethanol derivatives
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014665 Vasodilator Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C04AA 2-amino-1-phenylethanol derivatives 2 drugs
bamethanbuphenine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of blood vessel indication 27550009 DOID:178
Cerebrovascular disease indication 62914000 DOID:6713
Raynaud's disease indication 195295006 DOID:10300
Dysmenorrhea off-label use 266599000
Tachyarrhythmia contraindication 6285003
Low blood pressure contraindication 45007003
Arterial hemorrhage contraindication 234003006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.52 acidic
pKa2 8.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019794 VUID
N0000147883 NUI
D01748 KEGG_DRUG
579-56-6 SECONDARY_CAS_RN
4017883 VANDF
4019794 VANDF
C0022267 UMLSCUI
CHEBI:749216 CHEBI
CHEMBL1197051 ChEMBL_ID
CHEMBL559180 ChEMBL_ID
DB08941 DRUGBANK_ID
D007556 MESH_DESCRIPTOR_UI
11779629 PUBCHEM_CID
773 INN_ID
R15UI3245N UNII
6066 RXNORM
3350 MMSL
4938 MMSL
d00693 MMSL
000700 NDDF
004517 NDDF
3501003 SNOMEDCT_US
372818004 SNOMEDCT_US
68774008 SNOMEDCT_US
R15UI3245N INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ISOXSUPRINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 63549-919 TABLET 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections