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nicotinyl alcohol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| nicotinic acid or nicotinoyl alcohol derivatives | 1921 | 100-55-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
| 0.30 | g | P |
| 0.90 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,ITK,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,NTRK2,PDK2,PDK4,PIK3CB,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 36 | |||
| kinase-selectivity-class | ACVRL1,AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,MARK4,PIK3CD,PRKCD,PRKDC,SIK2 | 14 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C04AC02 | CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Nicotinic acid and derivatives |
| ATC | C10AD05 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN Nicotinic acid and derivatives |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:35679 | antilipemic drugs |
Related Drugs by ATC class:
C04AC Nicotinic acid and derivatives 3 drugs
C10AD Nicotinic acid and derivatives 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ménière's disease | indication | 13445001 | DOID:9849 |
| Hyperlipidemia | indication | 55822004 | DOID:1168 |
| Pellagra | indication | 418186002 | DOID:8457 |
| Niacin deficiency | indication | 418279001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.45 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 9TF312056Y | UNII |
| N0000006516 | NUI |
| D01789 | KEGG_DRUG |
| 4019083 | VANDF |
| C0028053 | UMLSCUI |
| CHEBI:45213 | CHEBI |
| PYF | PDB_CHEM_ID |
| CHEMBL1235535 | ChEMBL_ID |
| 7510 | PUBCHEM_CID |
| DB04145 | DRUGBANK_ID |
| D009540 | MESH_DESCRIPTOR_UI |
| 6164-87-0 | SECONDARY_CAS_RN |
| 235354 | RXNORM |
| 001054 | NDDF |
| 350628002 | SNOMEDCT_US |
| 419062009 | SNOMEDCT_US |
| 85335008 | SNOMEDCT_US |
Pharmaceutical products:
None