nicofuranose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1916 15351-13-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nicofuranose
  • bradilan
  • L-Nicofuranosum
  • nicofurazone
derivative of nicotinic acid that produces fewer side effects than pure nicotinic acid; used in peripheral vascular disease; also proposed as anticholesteremic; minor descriptor (75-84); on-line search NIACIN/AA (75-84); Index Medicus search NIACIN/AA (83-84), NICOTINIC ACIDS (75-82)
  • Molecular weight: 600.54
  • Formula: C30H24N4O10
  • CLOGP: 1.27
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 1
  • TPSA: 186.22
  • ALOGS: -4.01
  • ROTB: 14

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 68 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,JAK2,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPK9,MARK4,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 40
kinase-selectivity-class AXL,BRAF,CDK9,DYRK1B,EPHB4,ERBB2,GRK2,PRKDC,SIK2 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AD03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Nicotinic acid and derivatives
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:25212 metabolite
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35679 antilipemic drug
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:84087 human urinary metabolite
CHEBI has role CHEBI:84264 EC 3.5.1.19 (nicotinamidase) inhibitor
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

C10AD Nicotinic acid and derivatives 5 drugs
acipimoxaluminium nicotinateniceritrolnicotinic acidnicotinyl alcohol

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.83 acidic
pKa2 3.66 Basic
pKa3 3.22 Basic
pKa4 2.86 Basic
pKa5 2.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07189 KEGG_DRUG
4017661 VANDF
4019440 VANDF
C0354652 UMLSCUI
CHEBI:135846 CHEBI
NIO PDB_CHEM_ID
CHEMBL1697844 ChEMBL_ID
DB13422 DRUGBANK_ID
C100123 MESH_SUPPLEMENTAL_RECORD_UI
1565 INN_ID
GF99P6327K UNII
25495 PUBCHEM_CID
104486 RXNORM
2275 MMSL
43641 MMSL
5169 MMSL
7161 MMSL
d00314 MMSL
001052 NDDF
004010 NDDF
273943001 SNOMEDCT_US
319967001 SNOMEDCT_US
419843007 SNOMEDCT_US
63639004 SNOMEDCT_US
C0027996 UMLSCUI
DB00627 DRUGBANK_ID
938 PUBCHEM_CID
CHEBI:15940 CHEBI

Pharmaceutical products:

None