DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
acipimox 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antacids, aluminium derivatives
76
51037-30-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
acipimox
olbemox
olbetam
methylpyrazinecarboxylic acid 4-oxide
lipolysis inhibitor
Molecular weight: 154.13
Formula: C6H6N2O3
CLOGP: 0.28
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 75.65
ALOGS: -1.11
ROTB: 1
Drug dosage:
Dose
Unit
Route
0.50
g
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
90 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C10AD06
CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Nicotinic acid and derivatives
MeSH PA
D000963
Antimetabolites
MeSH PA
D000960
Hypolipidemic Agents
MeSH PA
D057847
Lipid Regulating Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hyperlipoproteinemia
indication
3744001
DOID:1168
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
3.88
acidic
pKa2
1.75
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Hydroxycarboxylic acid receptor 2
GPCR
Q8TDS4
HCAR2_HUMAN
AGONIST
EC50
5.60
IUPHAR
SCIENTIFIC LITERATURE
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External reference:
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entries
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ID
Source
003918
NDDF
1596
IUPHAR_LIGAND_ID
16817
RXNORM
319982006
SNOMEDCT_US
3809
INN_ID
391711008
SNOMEDCT_US
5310993
PUBCHEM_CID
C0050558
UMLSCUI
C027696
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:94688
CHEBI
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Pharmaceutical products:
None
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acipimox