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nadifloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 1864 | 124858-35-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
(R)-isomer does not induce chromosomal aberrations, unlike (S)-isomer; structure given in first source
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.25 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.54 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 6.04 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,EIF2AK3,GRK2,ITK,MAPK7,PDK1,PDK2,PDK4,PRKDC | 9 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK9,DYRK1B,EIF2AK3,EPHB4,GRK2,MAPK7,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK | 18 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D10AF05 | DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Antiinfectives for treatment of acne |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
| MeSH PA | D059005 | Topoisomerase II Inhibitors |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
Related Drugs by ATC class:
D10AF Antiinfectives for treatment of acne 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Acne vulgaris | indication | 88616000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.03 | acidic |
| pKa2 | 3.1 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01147 | KEGG_DRUG |
| CHEBI:31889 | CHEBI |
| CHEMBL363449 | ChEMBL_ID |
| C062127 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12919 | IUPHAR_LIGAND_ID |
| DB12447 | DRUGBANK_ID |
| 6CL9Y5YZEQ | UNII |
| 007854 | NDDF |
| 698260001 | SNOMEDCT_US |
| C0286402 | UMLSCUI |
| 6702 | INN_ID |
| 4410 | PUBCHEM_CID |
Pharmaceutical products:
None