metrizoic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1789 1949-45-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metrizoic acid
  • metrizoate
  • calcium metrizoate
  • meglumine metrizoate
  • metrizoate magnesium
  • metrizoate sodium
A diagnostic radiopaque that usually occurs as the sodium salt.
  • Molecular weight: 627.94
  • Formula: C12H11I3N2O4
  • CLOGP: 0.61
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 2
  • TPSA: 86.71
  • ALOGS: -3.85
  • ROTB: 3
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.64 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,DYRK3,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,FLT4,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 79
kinase-selectivity-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK16,CDK2,CDK4,CDK9,CLK2,CLK4,DDR1,DYRK1A,DYRK1B,DYRK3,EIF2AK3,EPHB4,ERBB2,FLT3,FLT4,GRK2,GSK3A,GSK3B,HIPK2,IRAK1,JAK1,JAK2,MAP2K3,MAP2K4,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK12,MAPK7,MARK4,MELK,MET,MTOR,PDK4,PIK3CB,PIK3CD,PIK3CG,PIM3,PRKAA1,PRKCZ,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TNIK,TTK,UHMK1,ULK1,ULK2,ZAP70 70
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Nov. 17, 1973 FDA GE HEALTHCARE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V08AA02 VARIOUS
CONTRAST MEDIA
X-RAY CONTRAST MEDIA, IODINATED
Watersoluble, nephrotropic, high osmolar X-ray contrast media
FDA MoA N0000010258 X-Ray Contrast Activity
MeSH PA D003287 Contrast Media
FDA EPC N0000180185 Radiographic Contrast Agent
CHEBI has role CHEBI:37338 radioopaque medium

Related Drugs by ATC class:

V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media 9 drugs
acetrizoic aciddiatrizoatediodoneiocarmic acidiodamideioglicic acidiotalamic acidioxitalamic acidmethiodal

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.34 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C4082771 UMLSCUI
CHEBI:34847 CHEBI
CHEMBL1736 ChEMBL_ID
D008794 MESH_DESCRIPTOR_UI
DB09346 DRUGBANK_ID
CM1N99QR1M UNII
2528 PUBCHEM_CID
000670 NDDF
000671 NDDF
354094002 SNOMEDCT_US
395792006 SNOMEDCT_US
CHEMBL2068723 ChEMBL_ID
CHEMBL1200353 ChEMBL_ID
CHEMBL2364738 ChEMBL_ID
CHEMBL1200423 ChEMBL_ID
20968-37-0 SECONDARY_CAS_RN
7225-61-8 SECONDARY_CAS_RN
1378 INN_ID

Pharmaceutical products:

None