diatrizoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
851 117-96-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amidotrizoic acid
  • diatrizoate
  • diatrizoic acid
  • urogranoic acid
  • diatrizoate sodium
  • diatrizoic acid dihydrate
A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
  • Molecular weight: 613.92
  • Formula: C11H9I3N2O4
  • CLOGP: 0.76
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 3
  • TPSA: 95.50
  • ALOGS: -3.76
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 2 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.26 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,DYRK3,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,FLT4,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 80
kinase-selectivity-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2A,CAMK2B,CAMK2D,CDK16,CDK2,CDK4,CDK9,CLK4,DDR1,DYRK1B,DYRK3,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT3,FLT4,GRK2,GSK3A,GSK3B,HIPK2,IRAK1,JAK2,MAP2K3,MAP2K4,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK12,MAPK7,MARK4,MET,MTOR,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM3,PRKAA1,PRKCZ,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1,ULK2,ZAP70 67
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 1954 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V08AA01 VARIOUS
CONTRAST MEDIA
X-RAY CONTRAST MEDIA, IODINATED
Watersoluble, nephrotropic, high osmolar X-ray contrast media
FDA MoA N0000010258 X-Ray Contrast Activity
MeSH PA D003287 Contrast Media
FDA EPC N0000180185 Radiographic Contrast Agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:37338 radioopaque medium
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media 9 drugs
acetrizoic aciddiodoneiocarmic acidiodamideioglicic acidiotalamic acidioxitalamic acidmethiodalmetrizoic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Visualization in excretion urography Indication
Cats Aortography Indication
Cats Angiocardiography, peripheral arteriography, and venography Indication
Cats Selective coronary arteriography Indication
Cats Cerebral angiography Indication
Cats Lymphography Indication
Cats Arthrography Indication
Cats Discography Indication
Cats Sialography Indication
Cats Delineating peritoneal hernias and fistulous tracts Indication
Dogs Visualization in excretion urography Indication
Dogs Aortography Indication
Dogs Angiocardiography, peripheral arteriography, and venography Indication
Dogs Selective coronary arteriography Indication
Dogs Cerebral angiography Indication
Dogs Lymphography Indication
Dogs Arthrography Indication
Dogs Discography Indication
Dogs Sialography Indication
Dogs Delineating peritoneal hernias and fistulous tracts Indication

🐶 Veterinary products

ProductApplicantIngredients
Renografin-76 Zoetis Inc. 2
Renografin-76 Zoetis Inc. 2
Renovist Zoetis Inc. 2
Renovist Zoetis Inc. 2
Gastrografin Zoetis Inc. 2
Gastrografin Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019713 VUID
N0000147805 NUI
D01013 KEGG_DRUG
737-31-5 SECONDARY_CAS_RN
1546223 RXNORM
4017588 VANDF
4019713 VANDF
C0012004 UMLSCUI
CHEBI:53691 CHEBI
CHEMBL1201220 ChEMBL_ID
CHEMBL1200581 ChEMBL_ID
D003973 MESH_DESCRIPTOR_UI
DB00271 DRUGBANK_ID
50978-11-5 SECONDARY_CAS_RN
2140 PUBCHEM_CID
4572 MMSL
d01473 MMSL
002345 NDDF
004886 NDDF
12335007 SNOMEDCT_US
396020008 SNOMEDCT_US
772986003 SNOMEDCT_US
773168007 SNOMEDCT_US
D003974 MESH_DESCRIPTOR_UI
358 INN_ID
5UVC90J1LK UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MD GASTROVIEW HUMAN PRESCRIPTION DRUG LABEL 2 0019-4816 SOLUTION 100 mg ORAL ANDA 19 sections
Gastrografin HUMAN PRESCRIPTION DRUG LABEL 2 0270-0445 LIQUID 100 mg ORAL NDA 20 sections
Diatrizoate Meglumine and Diatrizoate Sodium HUMAN PRESCRIPTION DRUG LABEL 2 31722-019 SOLUTION 100 mg ORAL ANDA 18 sections
Diatrizoate Meglumine and Diatrizoate Sodium Human Prescription Drug Label 2 53041-688 SOLUTION 100 mg ORAL ANDA 18 sections
Diatrizoate Meglumine and Diatrizoate Sodium Human Prescription Drug Label 2 53041-690 SOLUTION 100 mg ORAL ANDA 18 sections