diatrizoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 851 | 117-96-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 5 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.26 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.80 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 26, 1954 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V08AA01 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, high osmolar X-ray contrast media |
| FDA MoA | N0000010258 | X-Ray Contrast Activity |
| MeSH PA | D003287 | Contrast Media |
| MeSH PA | D064907 | Diagnostic Uses of Chemicals |
| FDA EPC | N0000180185 | Radiographic Contrast Agent |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:37338 | contrast media |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Visualization in excretion urography | Indication |
| Cats | Aortography | Indication |
| Cats | Angiocardiography, peripheral arteriography, and venography | Indication |
| Cats | Selective coronary arteriography | Indication |
| Cats | Cerebral angiography | Indication |
| Cats | Lymphography | Indication |
| Cats | Arthrography | Indication |
| Cats | Discography | Indication |
| Cats | Sialography | Indication |
| Cats | Delineating peritoneal hernias and fistulous tracts | Indication |
| Dogs | Visualization in excretion urography | Indication |
| Dogs | Aortography | Indication |
| Dogs | Angiocardiography, peripheral arteriography, and venography | Indication |
| Dogs | Selective coronary arteriography | Indication |
| Dogs | Cerebral angiography | Indication |
| Dogs | Lymphography | Indication |
| Dogs | Arthrography | Indication |
| Dogs | Discography | Indication |
| Dogs | Sialography | Indication |
| Dogs | Delineating peritoneal hernias and fistulous tracts | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Renografin-76 | Zoetis Inc. | 2 |
| Renografin-76 | Zoetis Inc. | 2 |
| Renovist | Zoetis Inc. | 2 |
| Renovist | Zoetis Inc. | 2 |
| Gastrografin | Zoetis Inc. | 2 |
| Gastrografin | Zoetis Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.45 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019713 | VUID |
| N0000147805 | NUI |
| D01013 | KEGG_DRUG |
| 737-31-5 | SECONDARY_CAS_RN |
| 1546223 | RXNORM |
| 4017588 | VANDF |
| 4019713 | VANDF |
| C0012004 | UMLSCUI |
| CHEBI:53691 | CHEBI |
| CHEMBL1201220 | ChEMBL_ID |
| CHEMBL1200581 | ChEMBL_ID |
| D003973 | MESH_DESCRIPTOR_UI |
| DB00271 | DRUGBANK_ID |
| 50978-11-5 | SECONDARY_CAS_RN |
| 2140 | PUBCHEM_CID |
| 4572 | MMSL |
| d01473 | MMSL |
| 002345 | NDDF |
| 004886 | NDDF |
| 12335007 | SNOMEDCT_US |
| 396020008 | SNOMEDCT_US |
| 772986003 | SNOMEDCT_US |
| 773168007 | SNOMEDCT_US |
| D003974 | MESH_DESCRIPTOR_UI |
| 358 | INN_ID |
| 5UVC90J1LK | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| MD GASTROVIEW | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0019-4816 | SOLUTION | 100 mg | ORAL | ANDA | 19 sections |
| Gastrografin | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0270-0445 | LIQUID | 100 mg | ORAL | NDA | 20 sections |
| Diatrizoate Meglumine and Diatrizoate Sodium | Human Prescription Drug Label | 2 | 53041-688 | SOLUTION | 100 mg | ORAL | ANDA | 18 sections |
| Diatrizoate Meglumine and Diatrizoate Sodium | Human Prescription Drug Label | 2 | 53041-690 | SOLUTION | 100 mg | ORAL | ANDA | 18 sections |