All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

mercaptopurine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
aptamers, classical and mirror ones	1708	50-44-2

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: mercaptopurine monohydrate 6-mercaptopurine monohydrate 6-mercaptopurine xaluprine mercaptopurine mercapurin purimethol purinethiol purinethol thiohypoxanthine mercaptopurine hydrate

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. Molecular weight: 152.18 Formula: C5H4N4S CLOGP: -1.33 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 53.07 ALOGS: -2.32 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	22 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	16.43 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	12 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	15 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.85 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.18 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Sept. 11, 1953	FDA	STASON PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	855.84	14.46	511	20057	117938	63350516
Febrile bone marrow aplasia	306.99	14.46	108	20460	7217	63461237
Venoocclusive liver disease	252.23	14.46	84	20484	4751	63463703
Crohn's disease	231.21	14.46	79	20489	4834	63463620
Pancytopenia	180.44	14.46	188	20380	96745	63371709
Temporal lobe epilepsy	138.12	14.46	31	20537	380	63468074
Neurotoxicity	118.74	14.46	72	20496	16918	63451536
Hyperbilirubinaemia	114.28	14.46	61	20507	11253	63457201
Rhinovirus infection	110.56	14.46	45	20523	4484	63463970
Off label use	105.43	14.46	464	20104	673998	62794456
Acute lymphocytic leukaemia recurrent	104.85	14.46	36	20532	2233	63466221
Pyrexia	104.64	14.46	362	20206	470116	62998338
Haematotoxicity	104.51	14.46	54	20514	9322	63459132
Hypertriglyceridaemia	96.56	14.46	45	20523	6214	63462240
Haemophagocytic lymphohistiocytosis	95.41	14.46	53	20515	10574	63457880
Colitis ulcerative	90.79	14.46	72	20496	26019	63442435
Human bocavirus infection	90.40	14.46	22	20546	391	63468063
Abdominal pain	85.43	14.46	248	20320	293208	63175246
Pancreatitis	76.92	14.46	87	20481	48968	63419486
Joint swelling	72.75	14.46	10	20558	327656	63140798
Acute myeloid leukaemia	69.91	14.46	52	20516	17095	63451359
Secondary immunodeficiency	68.04	14.46	23	20545	1360	63467094
Perineal necrosis	67.66	14.46	14	20554	113	63468341
Bacterial infection	66.10	14.46	53	20515	19446	63449008
Perineal infection	65.16	14.46	14	20554	138	63468316
Occupational asthma	64.44	14.46	14	20554	146	63468308
Enterobacter infection	64.37	14.46	25	20543	2202	63466252
Pain	64.24	14.46	88	20480	740540	62727914
Neoplasm recurrence	63.67	14.46	26	20542	2612	63465842
Gastroenteritis norovirus	62.57	14.46	24	20544	2044	63466410
Pneumatosis intestinalis	62.42	14.46	25	20543	2388	63466066
Enterovirus test positive	58.72	14.46	13	20555	149	63468305
Leukaemia recurrent	57.08	14.46	20	20548	1318	63467136
Bacillus infection	53.31	14.46	17	20551	836	63467618
Abdominal discomfort	52.84	14.46	19	20549	320866	63147588
Herpes simplex	52.56	14.46	33	20535	8238	63460216
Oesophageal dilatation	51.65	14.46	14	20554	387	63468067
Human rhinovirus test positive	51.15	14.46	12	20556	181	63468273
Human herpesvirus 6 infection	51.07	14.46	23	20545	2934	63465520
Colitis	50.34	14.46	70	20498	48458	63419996
Hepatosplenic T-cell lymphoma	50.32	14.46	15	20553	588	63467866
Bacterial vulvovaginitis	50.31	14.46	16	20552	780	63467674
Arthropathy	50.16	14.46	8	20560	234784	63233670
Mucosal inflammation	49.14	14.46	68	20500	46860	63421594
Hepatocellular injury	48.88	14.46	52	20516	27329	63441125
Fall	48.48	14.46	34	20534	392300	63076154
Alanine aminotransferase increased	48.33	14.46	105	20463	103665	63364789
Device related infection	48.22	14.46	48	20520	23344	63445110
Neutropenia	48.05	14.46	145	20423	174860	63293594
Bone marrow failure	47.70	14.46	53	20515	29237	63439217
Clostridium difficile colitis	47.65	14.46	45	20523	20524	63447930
Antithrombin III	47.52	14.46	11	20557	156	63468298
Sepsis	46.96	14.46	132	20436	152991	63315463
Peripheral swelling	46.84	14.46	14	20554	265928	63202526
Trichodysplasia spinulosa	46.62	14.46	14	20554	563	63467891
Synovitis	45.76	14.46	4	20564	186914	63281540
Venous thrombosis	45.51	14.46	25	20543	4877	63463577
Hypoglycaemia	43.05	14.46	73	20495	59992	63408462
Rectal cancer metastatic	42.85	14.46	11	20557	245	63468209
Swelling	42.52	14.46	18	20550	275360	63193094
Cholestasis	42.43	14.46	50	20518	29384	63439070
Female sterilisation	41.52	14.46	13	20555	602	63467852
Partial seizures	41.43	14.46	25	20543	5817	63462637
Second primary malignancy	41.39	14.46	28	20540	7925	63460529
Epstein-Barr virus infection	41.09	14.46	28	20540	8022	63460432
Perirectal abscess	40.15	14.46	14	20554	909	63467545
Central obesity	39.93	14.46	15	20553	1206	63467248
Myelopathy	39.55	14.46	19	20549	2807	63465647
Anal abscess	38.59	14.46	22	20546	4610	63463844
Anal fistula	38.27	14.46	20	20548	3531	63464923
Enteritis	38.03	14.46	27	20541	8259	63460195
Hepatotoxicity	37.77	14.46	53	20515	36988	63431466
Hypoalbuminaemia	37.71	14.46	31	20537	11774	63456680
Drug specific antibody present	37.56	14.46	21	20547	4238	63464216
Post lumbar puncture syndrome	37.36	14.46	12	20556	604	63467850
Death	37.08	14.46	40	20528	374341	63094113
Segmental diverticular colitis	36.72	14.46	9	20559	165	63468289
Pedal pulse abnormal	36.31	14.46	9	20559	173	63468281
Bile acid malabsorption	36.27	14.46	9	20559	174	63468280
Intestinal stenosis	36.19	14.46	18	20550	2866	63465588
Wound	36.15	14.46	5	20563	163258	63305196
Strongyloidiasis	36.03	14.46	14	20554	1234	63467220
Venoocclusive disease	35.52	14.46	16	20552	2042	63466412
Blood culture positive	35.49	14.46	21	20547	4714	63463740
Discomfort	35.07	14.46	6	20562	167368	63301086
Pleuroparenchymal fibroelastosis	34.93	14.46	8	20560	108	63468346
Fistula	34.69	14.46	28	20540	10365	63458089
Leukoencephalopathy	34.20	14.46	20	20548	4393	63464061
Hypertransaminasaemia	33.76	14.46	23	20545	6586	63461868
Leukopenia	33.49	14.46	76	20492	77214	63391240
Mucormycosis	33.33	14.46	17	20551	2854	63465600
Cerebral venous sinus thrombosis	32.99	14.46	15	20553	1957	63466497
Ileal stenosis	31.75	14.46	14	20554	1699	63466755
Vital capacity decreased	31.63	14.46	14	20554	1714	63466740
Calcium ionised decreased	31.59	14.46	9	20559	300	63468154
Enterovirus infection	31.51	14.46	12	20556	1002	63467452
Fatigue	31.33	14.46	165	20403	887863	62580591
Glioma	31.28	14.46	9	20559	311	63468143
Pseudomonas test positive	31.21	14.46	11	20557	737	63467717
Painful respiration	30.98	14.46	16	20552	2758	63465696
Intestinal resection	30.58	14.46	16	20552	2832	63465622
Insomnia	30.25	14.46	16	20552	215236	63253218
Musculoskeletal stiffness	30.24	14.46	11	20557	184607	63283847
Myelodysplastic syndrome	30.22	14.46	32	20536	16722	63451732
Staphylococcal sepsis	29.49	14.46	23	20545	8105	63460349
Subacute combined cord degeneration	29.49	14.46	8	20560	222	63468232
Pancreatitis acute	29.39	14.46	40	20528	27126	63441328
Cytomegalovirus infection	29.22	14.46	35	20533	20917	63447537
Lymphoproliferative disorder	28.87	14.46	16	20552	3174	63465280
Systemic lupus erythematosus	28.67	14.46	16	20552	208902	63259552
Dyspnoea	28.56	14.46	114	20454	661199	62807255
Vocal cord paralysis	28.40	14.46	14	20554	2187	63466267
Stress urinary incontinence	27.50	14.46	14	20554	2341	63466113
Porphyria non-acute	27.46	14.46	8	20560	289	63468165
Histoplasmosis disseminated	27.31	14.46	12	20556	1444	63467010
Lower respiratory tract infection	27.15	14.46	5	20563	132302	63336152
Feeding intolerance	27.11	14.46	10	20558	764	63467690
Epstein-Barr virus associated lymphoma	27.01	14.46	9	20559	509	63467945
Superior sagittal sinus thrombosis	26.90	14.46	10	20558	781	63467673
Large intestinal stenosis	26.87	14.46	13	20555	1950	63466504
Histoplasmosis	26.82	14.46	13	20555	1958	63466496
Acute lymphocytic leukaemia refractory	26.33	14.46	6	20562	79	63468375
Lung opacity	26.26	14.46	15	20553	3153	63465301
Abdominal adhesions	26.20	14.46	15	20553	3167	63465287
Jaundice	25.67	14.46	39	20529	29212	63439242
Blood bilirubin increased	25.11	14.46	44	20524	37096	63431358
Neutrophil count decreased	25.02	14.46	56	20512	56350	63412104
Seizure	25.02	14.46	97	20471	132537	63335917
Clostridium difficile infection	25.01	14.46	39	20529	29883	63438571
Cystitis bacterial	24.70	14.46	7	20561	229	63468225
Cardiotoxicity	24.56	14.46	21	20547	8417	63460037
Chloroma	24.49	14.46	7	20561	236	63468218
Encopresis	24.38	14.46	6	20562	112	63468342
Hepatic infection fungal	24.32	14.46	5	20563	39	63468415
Escherichia infection	24.15	14.46	25	20543	12729	63455725
Glossitis	23.97	14.46	14	20554	3068	63465386
Blood pressure abnormal	23.88	14.46	27	20541	15171	63453283
Haemolytic uraemic syndrome	23.88	14.46	13	20555	2490	63465964
Asthma	23.78	14.46	6	20562	127555	63340899
Influenza B virus test positive	23.69	14.46	7	20561	266	63468188
Aborted pregnancy	23.68	14.46	5	20563	45	63468409
Drug interaction	23.16	14.46	140	20428	228991	63239463
Metastases to pancreas	23.13	14.46	7	20561	289	63468165
Cytogenetic abnormality	23.07	14.46	8	20560	511	63467943
Pericarditis	23.01	14.46	7	20561	131572	63336882
Myelosuppression	22.81	14.46	33	20535	23670	63444784
Confusional state	22.56	14.46	26	20542	236354	63232100
Breakthrough pain	22.50	14.46	10	20558	1236	63467218
Cushingoid	22.45	14.46	20	20548	8465	63459989
Aplasia	22.18	14.46	15	20553	4244	63464210
Coagulopathy	21.84	14.46	30	20538	20514	63447940
Lipase increased	21.68	14.46	21	20547	9879	63458575
Drug level decreased	21.62	14.46	19	20549	7900	63460554
Pseudomonal sepsis	21.62	14.46	12	20556	2389	63466065
Disseminated trichosporonosis	21.40	14.46	5	20563	74	63468380
Haematochezia	21.38	14.46	51	20517	53493	63414961
Small intestinal obstruction	21.36	14.46	28	20540	18309	63450145
Gamma-glutamyltransferase increased	21.32	14.46	39	20529	33992	63434462
Viral infection	21.25	14.46	40	20528	35623	63432831
West Nile viral infection	21.04	14.46	7	20561	394	63468060
Inflammatory bowel disease	20.70	14.46	14	20554	3959	63464495
Gastrointestinal sounds abnormal	20.46	14.46	14	20554	4037	63464417
Overgrowth fungal	20.38	14.46	5	20563	92	63468362
Anaemia megaloblastic	20.25	14.46	7	20561	443	63468011
Hyperglycaemia	20.20	14.46	43	20525	41824	63426630
Respiratory tract haemorrhage	20.16	14.46	7	20561	449	63468005
Contusion	19.85	14.46	12	20556	150032	63318422
Psoriatic arthropathy	19.79	14.46	3	20565	91517	63376937
Meningitis coccidioides	19.71	14.46	4	20564	29	63468425
Bronchitis chronic	19.55	14.46	14	20554	4339	63464115
Proctalgia	19.42	14.46	16	20552	6094	63462360
Rectal abscess	19.09	14.46	9	20559	1274	63467180
Appendicitis	19.05	14.46	18	20550	8211	63460243
Intracardiac thrombus	18.88	14.46	11	20557	2399	63466055
Bone marrow disorder	18.87	14.46	11	20557	2403	63466051
Pneumonia fungal	18.85	14.46	15	20553	5440	63463014
Transverse sinus thrombosis	18.78	14.46	7	20561	551	63467903
Herpes zoster meningoencephalitis	18.76	14.46	6	20562	298	63468156
Rash	18.72	14.46	106	20462	560765	62907689
Staphylococcal bacteraemia	18.67	14.46	15	20553	5515	63462939
Hypophagia	18.55	14.46	35	20533	31224	63437230
Depersonalisation/derealisation disorder	18.52	14.46	9	20559	1363	63467091
Furuncle	18.42	14.46	16	20552	6550	63461904
Mucoepidermoid carcinoma	18.30	14.46	4	20564	43	63468411
Feeling abnormal	18.10	14.46	13	20555	148379	63320075
Hepatosplenomegaly	18.06	14.46	11	20557	2603	63465851
Dizziness	17.96	14.46	75	20493	429850	63038604
Pericardial cyst	17.81	14.46	3	20565	6	63468448
T-cell lymphoma	17.47	14.46	7	20561	669	63467785
Haematocolpos	17.39	14.46	4	20564	55	63468399
Oesophageal mass	17.39	14.46	4	20564	55	63468399
Pyoderma gangrenosum	17.07	14.46	12	20556	3613	63464841
Anal fissure	17.05	14.46	13	20555	4430	63464024
Thrombocytopenia	16.98	14.46	95	20473	151062	63317392
Ocular icterus	16.98	14.46	12	20556	3644	63464810
Acute myelomonocytic leukaemia	16.97	14.46	5	20563	188	63468266
Listeria sepsis	16.91	14.46	7	20561	728	63467726
Atypical haemolytic uraemic syndrome	16.91	14.46	7	20561	728	63467726
Osteoarthritis	16.80	14.46	5	20563	95338	63373116
Vomiting	16.68	14.46	264	20304	559353	62909101
Histiocytic sarcoma	16.55	14.46	4	20564	69	63468385
Blood cholesterol increased	16.44	14.46	5	20563	94027	63374427
Inappropriate schedule of product administration	16.42	14.46	72	20496	103893	63364561
Pruritus	16.39	14.46	61	20507	361392	63107062
Glioblastoma multiforme	16.31	14.46	7	20561	796	63467658
Toe walking	16.28	14.46	3	20565	12	63468442
Hemiparesis	16.28	14.46	28	20540	23254	63445200
Rhinocerebral mucormycosis	16.26	14.46	6	20562	459	63467995
Quadriplegia	16.21	14.46	9	20559	1791	63466663
Cerebral ischaemia	16.12	14.46	15	20553	6713	63461741
Norovirus test positive	16.02	14.46	5	20563	229	63468225
Atrial fibrillation	15.89	14.46	9	20559	116627	63351827
Diarrhoea haemorrhagic	15.83	14.46	17	20551	9025	63459429
Gambling	15.78	14.46	5	20563	241	63468213
Vulval disorder	15.75	14.46	7	20561	865	63467589
Aspergillus infection	15.57	14.46	16	20552	8077	63460377
Hepatic enzyme increased	15.54	14.46	26	20542	202302	63266152
Hippocampal sclerosis	15.50	14.46	4	20564	91	63468363
Intestinal operation	15.50	14.46	6	20562	524	63467930
Intestinal fistula	15.48	14.46	7	20561	901	63467553
Pneumocystis jirovecii pneumonia	15.48	14.46	23	20545	16891	63451563
Drug intolerance	15.40	14.46	50	20518	308611	63159843
Respiratory distress	15.38	14.46	34	20534	33917	63434537
Functional gastrointestinal disorder	15.34	14.46	12	20556	4247	63464207
Malaise	15.31	14.46	76	20492	415878	63052576
Alopecia	15.28	14.46	57	20511	337479	63130975
Lennox-Gastaut syndrome	15.19	14.46	5	20563	272	63468182
Potentiating drug interaction	15.10	14.46	12	20556	4344	63464110
Aplastic anaemia	15.04	14.46	17	20551	9552	63458902
Cerebral fungal infection	15.03	14.46	4	20564	103	63468351
Pseudopolyp	15.00	14.46	5	20563	283	63468171
Cerebral haemangioma	14.96	14.46	4	20564	105	63468349
Amylase increased	14.92	14.46	14	20554	6331	63462123
Listeriosis	14.79	14.46	8	20560	1513	63466941
Anogenital dysplasia	14.75	14.46	3	20565	22	63468432
Pericardial effusion	14.65	14.46	31	20537	30027	63438427
Somnolence	14.64	14.46	22	20546	178663	63289791
Papulopustular rosacea	14.52	14.46	3	20565	24	63468430

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1029.62	14.23	776	21143	136073	34798939
Hepatosplenic T-cell lymphoma	259.34	14.23	60	21859	410	34934602
Venoocclusive liver disease	226.12	14.23	107	21812	7859	34927153
Febrile bone marrow aplasia	202.02	14.23	100	21819	8109	34926903
Haematotoxicity	190.39	14.23	96	21823	8098	34926914
Death	150.90	14.23	33	21886	398016	34536996
Hypertriglyceridaemia	150.82	14.23	83	21836	8365	34926647
Pancytopenia	126.02	14.23	219	21700	94938	34840074
Acute lymphocytic leukaemia recurrent	111.98	14.23	49	21870	2995	34932017
Bone marrow failure	107.37	14.23	111	21808	29142	34905870
Pyrexia	104.90	14.23	449	21470	332564	34602448
Hepatotoxicity	98.36	14.23	92	21827	21393	34913619
Osteonecrosis	97.02	14.23	78	21841	14812	34920200
Pancreatitis	94.22	14.23	119	21800	38772	34896240
Haemophagocytic lymphohistiocytosis	93.23	14.23	72	21847	12901	34922111
Myelosuppression	93.05	14.23	85	21834	19180	34915832
Cytomegalovirus chorioretinitis	92.09	14.23	45	21874	3544	34931468
Multiple-drug resistance	89.47	14.23	50	21869	5189	34929823
Crohn's disease	88.83	14.23	42	21877	3075	34931937
Leukoencephalopathy	82.42	14.23	44	21875	4171	34930841
Colitis	79.77	14.23	108	21811	37642	34897370
Abdominal pain	76.66	14.23	251	21668	163367	34771645
Neutropenia	75.70	14.23	243	21676	156535	34778477
Mucosal inflammation	71.93	14.23	104	21815	38518	34896494
Nodular regenerative hyperplasia	68.45	14.23	25	21894	948	34934064
Off label use	65.06	14.23	467	21452	419057	34515955
Lentigo	59.16	14.23	19	21900	485	34934527
Glioma	56.29	14.23	17	21902	352	34934660
Colitis ulcerative	55.81	14.23	60	21859	16460	34918552
Enterovirus infection	53.66	14.23	21	21898	965	34934047
Acute myeloid leukaemia	52.53	14.23	61	21858	18209	34916803
Portal hypertension	51.55	14.23	32	21887	4030	34930982
Myelodysplastic syndrome	50.06	14.23	61	21858	19147	34915865
Myocardial infarction	50.03	14.23	8	21911	121077	34813935
Frequent bowel movements	49.58	14.23	50	21869	12737	34922275
Epstein-Barr virus associated lymphoproliferative disorder	48.52	14.23	24	21895	1940	34933072
Gastrointestinal wall thickening	48.33	14.23	22	21897	1476	34933536
Epstein-Barr virus infection	47.65	14.23	39	21880	7589	34927423
Drug clearance decreased	47.26	14.23	23	21896	1795	34933217
Pancreatitis acute	46.96	14.23	72	21847	28069	34906943
Dyspnoea	46.50	14.23	105	21814	376677	34558335
Fall	45.96	14.23	36	21883	202849	34732163
Venoocclusive disease	45.27	14.23	26	21893	2841	34932171
Gallbladder oedema	45.01	14.23	13	21906	229	34934783
Cytogenetic abnormality	44.99	14.23	18	21901	877	34934135
Glioblastoma multiforme	44.73	14.23	17	21902	721	34934291
Hyperbilirubinaemia	44.72	14.23	54	21865	16789	34918223
Atrial fibrillation	44.47	14.23	11	21908	122382	34812630
Histoplasmosis disseminated	43.92	14.23	20	21899	1343	34933669
Intestinal stenosis	43.25	14.23	23	21896	2163	34932849
Dizziness	41.00	14.23	46	21873	218475	34716537
B-cell lymphoma	39.87	14.23	28	21891	4335	34930677
Fistula	38.64	14.23	33	21886	6807	34928205
Second primary malignancy	38.46	14.23	35	21884	7851	34927161
Cardiac failure congestive	37.99	14.23	4	21915	83266	34851746
Parainfluenzae virus infection	37.71	14.23	23	21896	2807	34932205
Diffuse large B-cell lymphoma	36.51	14.23	33	21886	7337	34927675
Rhinovirus infection	35.64	14.23	26	21893	4273	34930739
Haematopoietic neoplasm	35.47	14.23	8	21911	48	34934964
Sepsis	34.59	14.23	200	21719	166361	34768651
Neurotoxicity	34.24	14.23	49	21870	17961	34917051
Candida endophthalmitis	34.06	14.23	9	21910	112	34934900
Cytomegalovirus infection	33.01	14.23	59	21860	26076	34908936
Neutrophil count decreased	32.01	14.23	87	21832	51017	34883995
Acute monocytic leukaemia	31.95	14.23	11	21908	350	34934662
Leukopenia	31.68	14.23	99	21820	62757	34872255
Ileal stenosis	31.54	14.23	16	21903	1365	34933647
Alanine aminotransferase increased	30.84	14.23	116	21803	80699	34854313
Hepatocellular injury	30.47	14.23	52	21867	22159	34912853
Inflammatory bowel disease	29.66	14.23	20	21899	2900	34932112
Intracranial pressure increased	28.51	14.23	22	21897	3933	34931079
Xanthogranuloma	28.45	14.23	7	21912	64	34934948
Stomatitis	28.26	14.23	74	21845	42440	34892572
Pneumonia fungal	27.95	14.23	28	21891	7072	34927940
Proctitis	27.85	14.23	18	21901	2431	34932581
Thrombocytopenia	27.62	14.23	180	21739	156067	34778945
Vomiting	26.51	14.23	254	21665	247367	34687645
Leukaemia recurrent	26.45	14.23	15	21904	1600	34933412
Anal abscess	26.36	14.23	26	21893	6447	34928565
Cytopenia	26.24	14.23	36	21883	12687	34922325
Bacterial infection	26.16	14.23	42	21877	17021	34917991
Fungal infection	25.50	14.23	40	21879	15895	34919117
Mixed anxiety and depressive disorder	25.47	14.23	7	21912	102	34934910
Myelopathy	25.11	14.23	17	21902	2480	34932532
Depression	24.92	14.23	15	21904	97083	34837929
Human rhinovirus test positive	24.66	14.23	8	21911	211	34934801
Peripheral swelling	23.96	14.23	9	21910	76532	34858480
Hepatic steatosis	23.89	14.23	42	21877	18320	34916692
Product dose omission issue	23.76	14.23	24	21895	119687	34815325
Malignant neoplasm progression	23.45	14.23	13	21906	88033	34846979
Lymphopenia	23.41	14.23	39	21880	16296	34918716
Asthenia	22.96	14.23	78	21841	245173	34689839
Superior sagittal sinus thrombosis	22.90	14.23	8	21911	266	34934746
Transaminases increased	22.42	14.23	51	21868	26772	34908240
Adrenocortical carcinoma	22.31	14.23	5	21914	29	34934983
Cytomegalovirus hepatitis	22.20	14.23	9	21910	454	34934558
Multiple lentigines syndrome	22.03	14.23	5	21914	31	34934981
Abscess limb	22.00	14.23	18	21901	3499	34931513
Neoplasm recurrence	21.88	14.23	15	21904	2234	34932778
Cardiac arrest	21.82	14.23	17	21902	96142	34838870
Blood fibrinogen decreased	21.71	14.23	12	21907	1218	34933794
Acral lentiginous melanoma	21.63	14.23	5	21914	34	34934978
Completed suicide	21.47	14.23	18	21901	98150	34836862
Steatohepatitis	21.40	14.23	8	21911	324	34934688
Rhabdomyolysis	21.36	14.23	8	21911	68155	34866857
Cytomegalovirus colitis	21.20	14.23	16	21903	2768	34932244
Cerebral venous sinus thrombosis	20.85	14.23	9	21910	532	34934480
Mucormycosis	20.80	14.23	22	21897	5920	34929092
Anal fistula	20.72	14.23	21	21898	5378	34929634
Chronic obstructive pulmonary disease	20.72	14.23	3	21916	48915	34886097
Staphylococcal sepsis	20.52	14.23	28	21891	9816	34925196
Dysplastic naevus syndrome	20.50	14.23	4	21915	10	34935002
Coronary artery disease	20.37	14.23	3	21916	48302	34886710
Chest pain	20.31	14.23	30	21889	126732	34808280
Thymus enlargement	19.83	14.23	5	21914	51	34934961
Intestinal diaphragm disease	19.78	14.23	7	21912	242	34934770
Otitis media acute	19.74	14.23	9	21910	606	34934406
Proctalgia	19.70	14.23	21	21898	5702	34929310
Trichodysplasia spinulosa	19.62	14.23	7	21912	248	34934764
Confusional state	19.53	14.23	38	21881	144122	34790890
Small intestinal obstruction	19.33	14.23	34	21885	14832	34920180
Minimal residual disease	19.27	14.23	8	21911	429	34934583
Somnolence	19.10	14.23	25	21894	111091	34823921
Cholestasis	19.03	14.23	48	21871	26900	34908112
General physical health deterioration	18.99	14.23	32	21887	128237	34806775
Renal failure	18.94	14.23	33	21886	130524	34804488
Aspergillus infection	18.56	14.23	30	21889	12224	34922788
Syncope	18.52	14.23	18	21901	91433	34843579
Anal inflammation	18.44	14.23	11	21908	1289	34933723
Human anaplasmosis	18.38	14.23	5	21914	70	34934942
T-cell lymphoma	18.31	14.23	10	21909	991	34934021
Pneumocystis jirovecii pneumonia	18.19	14.23	39	21880	19671	34915341
Pruritus	17.89	14.23	39	21880	141942	34793070
Small intestinal stenosis	17.73	14.23	8	21911	526	34934486
Vascular access complication	17.60	14.23	7	21912	336	34934676
Meningitis enterococcal	17.59	14.23	5	21914	83	34934929
Neutropenic colitis	17.42	14.23	15	21904	3129	34931883
Metapneumovirus infection	17.39	14.23	9	21910	800	34934212
Cardiac failure	17.30	14.23	19	21900	91229	34843783
Cutaneous leishmaniasis	16.91	14.23	6	21913	209	34934803
Human metapneumovirus test positive	16.81	14.23	5	21914	98	34934914
Disseminated cytomegaloviral infection	16.62	14.23	6	21913	220	34934792
Cheilitis	16.58	14.23	13	21906	2378	34932634
Escherichia infection	16.51	14.23	23	21896	8222	34926790
Hip deformity	16.49	14.23	5	21914	105	34934907
Bifidobacterium infection	16.31	14.23	4	21915	36	34934976
Anorectal cellulitis	16.22	14.23	4	21915	37	34934975
Hypoalbuminaemia	16.03	14.23	28	21891	12146	34922866
Epstein-Barr virus associated lymphoma	16.02	14.23	8	21911	660	34934352
Respiratory distress	15.99	14.23	54	21865	35611	34899401
Posterior reversible encephalopathy syndrome	15.94	14.23	25	21894	9929	34925083
Oedema peripheral	15.86	14.23	32	21887	119780	34815232
Gastrointestinal injury	15.60	14.23	7	21912	454	34934558
Meningoradiculitis	15.51	14.23	4	21915	45	34934967
Pneumonia viral	15.31	14.23	14	21905	3160	34931852
Colon dysplasia	15.30	14.23	5	21914	135	34934877
Central nervous system leukaemia	15.24	14.23	6	21913	280	34934732
Seizure	15.10	14.23	115	21804	104742	34830270
Eosinophilic pneumonia chronic	15.06	14.23	6	21913	289	34934723
Coccidioidomycosis	14.97	14.23	8	21911	759	34934253
Babesiosis	14.93	14.23	5	21914	146	34934866
Coma	14.93	14.23	5	21914	45673	34889339
Blood glucose increased	14.87	14.23	12	21907	66706	34868306
Pulmonary mucormycosis	14.82	14.23	8	21911	775	34934237
Eye opacity	14.73	14.23	3	21916	10	34935002
Haemorrhagic diathesis	14.72	14.23	13	21906	2803	34932209
Clostridium test positive	14.69	14.23	14	21905	3328	34931684
Hallucination	14.60	14.23	7	21912	51491	34883521
Tonsil cancer	14.53	14.23	9	21910	1129	34933883
Large intestine infection	14.47	14.23	10	21909	1508	34933504
Autoimmune lymphoproliferative syndrome	14.46	14.23	5	21914	161	34934851
Clostridium difficile colitis	14.37	14.23	31	21888	15699	34919313
Electrocardiogram QT prolonged	14.25	14.23	4	21915	40948	34894064

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1816.52	12.83	1204	36313	229795	79477076
Secondary immunodeficiency	316.02	12.83	99	37418	3135	79703736
Haematotoxicity	301.91	12.83	147	37370	15372	79691499
Pancytopenia	294.68	12.83	376	37141	165369	79541502
Bacterial infection	256.11	12.83	168	37349	31112	79675759
Febrile bone marrow aplasia	255.28	12.83	124	37393	12896	79693975
Hepatosplenic T-cell lymphoma	234.20	12.83	59	37458	819	79706052
Hypertriglyceridaemia	196.05	12.83	103	37414	12637	79694234
Haemophagocytic lymphohistiocytosis	187.85	12.83	121	37396	21716	79685155
Cytomegalovirus chorioretinitis	183.67	12.83	76	37441	5414	79701457
Rhinovirus infection	174.97	12.83	82	37435	7871	79699000
Acute lymphocytic leukaemia recurrent	173.78	12.83	70	37447	4654	79702217
Parainfluenzae virus infection	171.16	12.83	73	37444	5609	79701262
Pyrexia	166.75	12.83	695	36822	678014	79028857
Pancreatitis	160.26	12.83	179	37338	68396	79638475
Mycobacterium chelonae infection	158.65	12.83	55	37462	2401	79704470
Off label use	156.48	12.83	838	36679	906377	78800494
Bone marrow failure	148.87	12.83	150	37367	50957	79655914
Human bocavirus infection	140.44	12.83	38	37479	707	79706164
Clostridium difficile colitis	131.11	12.83	114	37403	32169	79674702
Myelodysplastic syndrome transformation	129.21	12.83	35	37482	654	79706217
Pseudomonal sepsis	127.67	12.83	61	37456	6113	79700758
Human herpesvirus 6 infection	123.19	12.83	57	37460	5313	79701558
Neurotoxicity	122.42	12.83	110	37407	32408	79674463
Mucosal inflammation	119.43	12.83	162	37355	75418	79631453
Hepatotoxicity	118.17	12.83	133	37384	51219	79655652
Acute myeloid leukaemia	115.33	12.83	104	37413	30781	79676090
Osteonecrosis	114.72	12.83	104	37413	30991	79675880
Neutropenia	111.86	12.83	343	37174	287367	79419504
Myelosuppression	107.80	12.83	113	37404	40183	79666688
Second primary malignancy	105.23	12.83	72	37445	14278	79692593
Leukoencephalopathy	104.92	12.83	58	37459	7871	79699000
Hyperbilirubinaemia	104.47	12.83	89	37428	24429	79682442
Thymus hypoplasia	104.38	12.83	32	37485	941	79705930
Viral infection	101.70	12.83	113	37404	42903	79663968
Fall	97.71	12.83	54	37463	487575	79219296
Abdominal pain	97.67	12.83	402	37115	389167	79317704
Multiple-drug resistance	93.99	12.83	56	37461	8752	79698119
Norovirus test positive	93.81	12.83	27	37490	635	79706236
Lymphoid tissue hypoplasia	93.07	12.83	29	37488	901	79705970
Cystitis bacterial	91.94	12.83	27	37490	683	79706188
Glioma	90.96	12.83	26	37491	596	79706275
Pneumatosis intestinalis	90.75	12.83	49	37468	6348	79700523
Enterovirus infection	86.21	12.83	33	37484	1914	79704957
Dyspnoea	85.39	12.83	172	37345	856853	78850018
Enterobacter infection	85.07	12.83	42	37475	4520	79702351
Rheumatoid arthritis	84.74	12.83	3	37514	208467	79498404
Myelodysplastic syndrome	82.88	12.83	86	37431	30215	79676656
Colitis ulcerative	81.66	12.83	91	37426	34651	79672220
Aspergillus infection	78.47	12.83	68	37449	19093	79687778
Joint swelling	77.67	12.83	20	37497	288626	79418245
Epstein-Barr virus infection	77.62	12.83	60	37457	14356	79692515
Viraemia	77.06	12.83	34	37483	2835	79704036
Neoplasm recurrence	76.22	12.83	38	37479	4176	79702695
Venoocclusive disease	76.17	12.83	39	37478	4534	79702337
Temporal lobe epilepsy	75.94	12.83	21	37496	425	79706446
Cytogenetic abnormality	75.79	12.83	26	37491	1099	79705772
Pancreatitis acute	74.84	12.83	104	37413	49500	79657371
Colitis	74.47	12.83	128	37389	73179	79633692
Enteritis	72.70	12.83	58	37459	14525	79692346
Leukaemia recurrent	71.70	12.83	32	37485	2742	79704129
Sepsis	71.38	12.83	283	37234	269145	79437726
Abscess bacterial	71.03	12.83	23	37494	811	79706060
Nodular regenerative hyperplasia	70.95	12.83	26	37491	1335	79705536
Death	70.86	12.83	98	37419	566416	79140455
Peripheral swelling	70.05	12.83	20	37497	269597	79437274
Myelopathy	69.97	12.83	37	37480	4596	79702275
Crohn's disease	67.16	12.83	28	37489	2032	79704839
Histoplasmosis disseminated	66.82	12.83	29	37488	2324	79704547
Glioblastoma multiforme	66.03	12.83	24	37493	1204	79705667
Human rhinovirus test positive	65.10	12.83	19	37498	470	79706401
Lentigo	64.64	12.83	19	37498	482	79706389
Trichodysplasia spinulosa	64.05	12.83	21	37496	771	79706100
Fungal infection	63.68	12.83	88	37429	41660	79665211
Cytomegalovirus infection	62.23	12.83	88	37429	42556	79664315
Leukopenia	62.11	12.83	156	37361	116357	79590514
Perineal necrosis	61.60	12.83	14	37503	121	79706750
Completed suicide	60.66	12.83	20	37497	245747	79461124
Pain	60.42	12.83	153	37364	703649	79003222
Contraindicated product administered	58.50	12.83	4	37513	157534	79549337
Intestinal stenosis	56.75	12.83	30	37487	3724	79703147
Intracardiac thrombus	55.69	12.83	31	37486	4262	79702609
Epstein-Barr virus associated lymphoproliferative disorder	55.60	12.83	29	37488	3503	79703368
Dizziness	55.47	12.83	102	37415	526339	79180532
Enterovirus test positive	54.89	12.83	15	37502	290	79706581
Venoocclusive liver disease	54.84	12.83	45	37472	11726	79695145
Fistula	53.14	12.83	46	37471	12894	79693977
Alanine aminotransferase increased	52.41	12.83	182	37335	162388	79544483
Bronchopulmonary aspergillosis	51.71	12.83	58	37459	22236	79684635
Cytomegalovirus viraemia	51.49	12.83	45	37472	12776	79694095
Neutrophil count decreased	51.33	12.83	127	37390	93832	79613039
Atrial fibrillation	50.80	12.83	15	37502	197871	79509000
Pneumonia fungal	50.44	12.83	42	37475	11168	79695703
Diffuse large B-cell lymphoma	49.51	12.83	43	37474	12106	79694765
Diffuse alveolar damage	49.44	12.83	27	37490	3577	79703294
Bacillus infection	49.08	12.83	19	37498	1136	79705735
Coronavirus infection	48.86	12.83	35	37482	7462	79699409
Drug clearance decreased	48.64	12.83	26	37491	3301	79703570
Cerebral venous sinus thrombosis	48.48	12.83	23	37494	2268	79704603
Hepatocellular injury	48.19	12.83	83	37434	47510	79659361
Molluscum contagiosum	47.90	12.83	15	37502	474	79706397
Swelling	47.86	12.83	21	37496	216690	79490181
Thrombocytopenia	47.31	12.83	248	37269	265011	79441860
Mucormycosis	47.24	12.83	36	37481	8433	79698438
Device related infection	44.56	12.83	67	37450	34227	79672644
Synovitis	43.39	12.83	9	37508	150725	79556146
Cholestasis	42.78	12.83	83	37434	52026	79654845
Oesophageal candidiasis	42.44	12.83	35	37482	9183	79697688
Anal abscess	41.99	12.83	35	37482	9320	79697551
Bacterial vulvovaginitis	40.83	12.83	14	37503	591	79706280
Cell-mediated immune deficiency	40.58	12.83	10	37507	126	79706745
B-cell lymphoma	40.47	12.83	29	37488	6186	79700685
Seizure	40.40	12.83	186	37331	188648	79518223
Intestinal resection	40.38	12.83	24	37493	3733	79703138
Hypertransaminasaemia	40.32	12.83	38	37479	11886	79694985
Superior sagittal sinus thrombosis	39.95	12.83	16	37501	1047	79705824
Subacute combined cord degeneration	39.94	12.83	12	37505	329	79706542
Feeding intolerance	39.60	12.83	15	37502	845	79706026
Epstein-Barr virus associated lymphoma	39.58	12.83	16	37501	1073	79705798
Discomfort	39.41	12.83	6	37511	125611	79581260
Intracranial pressure increased	39.15	12.83	32	37485	8290	79698581
Gastroenteritis norovirus	39.13	12.83	22	37495	3084	79703787
Hypoalbuminaemia	38.82	12.83	49	37468	21248	79685623
Lower respiratory tract infection	38.70	12.83	7	37510	129213	79577658
Confusional state	38.70	12.83	56	37461	317941	79388930
Pruritus	38.46	12.83	80	37437	394568	79312303
Abdominal discomfort	38.15	12.83	37	37480	250690	79456181
Frequent bowel movements	37.37	12.83	57	37460	29482	79677389
Encephalitis	37.00	12.83	40	37477	14720	79692151
Portal hypertension	37.00	12.83	29	37488	7079	79699792
Perineal infection	36.89	12.83	14	37503	793	79706078
Cardiac failure congestive	36.16	12.83	11	37506	142391	79564480
Inflammatory bowel disease	35.95	12.83	26	37491	5625	79701246
Bile acid malabsorption	35.86	12.83	10	37507	209	79706662
Anal fistula	35.43	12.83	28	37489	6916	79699955
Escherichia infection	35.32	12.83	43	37474	17974	79688897
Fatigue	35.14	12.83	275	37242	929452	78777419
Arthropathy	34.84	12.83	20	37497	177091	79529780
Pneumocystis jirovecii pneumonia	34.63	12.83	58	37459	32450	79674421
Cytopenia	34.18	12.83	45	37472	20338	79686533
Proctalgia	34.06	12.83	32	37485	9969	79696902
Haematopoietic neoplasm	33.63	12.83	8	37509	86	79706785
Segmental diverticular colitis	33.38	12.83	9	37508	165	79706706
Asthma	33.30	12.83	11	37506	135084	79571787
Candida endophthalmitis	33.28	12.83	9	37508	167	79706704
Cytomegalovirus colitis	33.15	12.83	23	37494	4662	79702209
Ileal stenosis	32.99	12.83	18	37499	2380	79704491
Depression	32.97	12.83	32	37485	216758	79490113
Perirectal abscess	32.82	12.83	17	37500	2024	79704847
Muscle spasms	32.60	12.83	21	37496	174709	79532162
Hyperkalaemia	32.57	12.83	7	37510	114391	79592480
Pedal pulse abnormal	32.41	12.83	9	37508	185	79706686
Glossodynia	32.27	12.83	5	37512	103332	79603539
Rectal cancer metastatic	32.06	12.83	11	37506	465	79706406
Strongyloidiasis	32.04	12.83	21	37496	3877	79702994
Lipase increased	31.80	12.83	39	37478	16427	79690444
Coagulopathy	31.59	12.83	59	37458	35947	79670924
Systemic lupus erythematosus	31.42	12.83	9	37508	121140	79585731
Acute monocytic leukaemia	30.73	12.83	11	37506	528	79706343
Blood culture positive	30.70	12.83	28	37489	8401	79698470
Lymphopenia	30.55	12.83	53	37464	30504	79676367
Histoplasmosis	30.47	12.83	17	37500	2348	79704523
Blood fibrinogen decreased	30.44	12.83	16	37501	1963	79704908
Drug specific antibody present	30.09	12.83	25	37492	6627	79700244
Cellulitis	29.99	12.83	116	37401	108944	79597927
Pleuroparenchymal fibroelastosis	29.66	12.83	8	37509	147	79706724
Haemolytic uraemic syndrome	29.52	12.83	21	37496	4428	79702443
Xanthogranuloma	29.45	12.83	7	37510	75	79706796
Disseminated aspergillosis	29.23	12.83	13	37504	1105	79705766
Anal inflammation	29.17	12.83	14	37503	1416	79705455
Malaise	29.14	12.83	125	37392	489744	79217127
Intentional overdose	29.13	12.83	7	37510	105953	79600918
Insomnia	29.01	12.83	44	37473	245126	79461745
Product dose omission issue	28.74	12.83	45	37472	247492	79459379
Venous thrombosis	28.62	12.83	25	37492	7091	79699780
Pseudomonas test positive	28.56	12.83	15	37502	1837	79705034
Blood bilirubin increased	28.54	12.83	82	37435	66150	79640721
Oedema peripheral	28.22	12.83	47	37470	252241	79454630
Cushingoid	27.73	12.83	28	37489	9524	79697347
Musculoskeletal stiffness	27.58	12.83	25	37492	174983	79531888
Atypical haemolytic uraemic syndrome	26.98	12.83	12	37505	1020	79705851
Cardiotoxicity	26.95	12.83	31	37486	12208	79694663
Chloroma	26.91	12.83	11	37506	759	79706112
Cytomegalovirus hepatitis	26.72	12.83	11	37506	773	79706098
Syncope	26.69	12.83	27	37490	179422	79527449
Asthenia	26.65	12.83	137	37380	511552	79195319
Aplasia	26.59	12.83	25	37492	7795	79699076
Central obesity	26.41	12.83	14	37503	1747	79705124
Abdominal adhesions	26.36	12.83	18	37499	3555	79703316
Somnolence	26.29	12.83	45	37472	238936	79467935
Vomiting	26.15	12.83	449	37068	665379	79041492
Drug level decreased	26.03	12.83	33	37484	14369	79692502
Cerebral haemangioma	25.98	12.83	7	37510	128	79706743
Hepatosplenomegaly	25.78	12.83	22	37495	6047	79700824
Transaminases increased	25.20	12.83	67	37450	51676	79655195
Mobility decreased	25.18	12.83	13	37504	122162	79584709
Neutropenic colitis	24.88	12.83	21	37496	5686	79701185
Pericarditis	24.80	12.83	9	37508	104227	79602644
Feeling abnormal	24.78	12.83	23	37494	159176	79547695
Hippocampal sclerosis	24.76	12.83	7	37510	154	79706717
Drug intolerance	24.50	12.83	55	37462	264064	79442807
Wound	24.49	12.83	12	37505	116167	79590704
Chest pain	24.42	12.83	61	37456	282243	79424628
Neuropathy peripheral	24.39	12.83	131	37386	141174	79565697
Acute lymphocytic leukaemia refractory	24.38	12.83	7	37510	163	79706708
Cheilitis	24.00	12.83	20	37497	5321	79701550
Hyponatraemia	23.98	12.83	29	37488	177819	79529052
Malnutrition	23.77	12.83	40	37477	22462	79684409
Antithrombin III	23.57	12.83	6	37511	87	79706784
Osteoarthritis	23.55	12.83	6	37511	87303	79619568
Gastrointestinal wall thickening	23.53	12.83	15	37502	2642	79704229
Metapneumovirus infection	23.46	12.83	13	37504	1771	79705100
Coma	23.43	12.83	9	37508	100640	79606231
General physical health deterioration	23.40	12.83	60	37457	275178	79431693
Anorectal cellulitis	23.26	12.83	6	37511	92	79706779
Abscess limb	23.01	12.83	22	37495	7005	79699866
Calcium ionised decreased	22.63	12.83	9	37508	578	79706293
Large intestinal stenosis	22.54	12.83	15	37502	2841	79704030
Hypoglycaemia	22.40	12.83	101	37416	101493	79605378
Staphylococcal sepsis	22.39	12.83	31	37486	14695	79692176
Bifidobacterium infection	22.34	12.83	5	37512	40	79706831
Herpes simplex	22.14	12.83	28	37489	12159	79694712
Meningitis coccidioides	21.82	12.83	5	37512	45	79706826
Aborted pregnancy	21.82	12.83	5	37512	45	79706826
Suicide attempt	21.80	12.83	6	37511	82926	79623945
Thymus enlargement	21.44	12.83	6	37511	127	79706744
Acral lentiginous melanoma	21.44	12.83	5	37512	49	79706822
Vocal cord paralysis	21.42	12.83	14	37503	2573	79704298
T-cell lymphoma	21.37	12.83	11	37506	1292	79705579
Rash	21.34	12.83	172	37345	578186	79128685
Anal fissure	21.31	12.83	22	37495	7681	79699190
Otitis media acute	21.11	12.83	11	37506	1326	79705545
Hallucination	21.10	12.83	7	37510	85738	79621133
Hemiparesis	21.01	12.83	48	37469	33685	79673186
Urinary tract infection	20.98	12.83	63	37454	274449	79432422
Chronic obstructive pulmonary disease	20.97	12.83	7	37510	85412	79621459
Angioedema	20.95	12.83	5	37512	76030	79630841
Coronary artery disease	20.83	12.83	3	37514	65471	79641400
Clostridium test positive	20.74	12.83	20	37497	6434	79700437
Anxiety	20.49	12.83	55	37462	248457	79458414
Fusarium infection	20.47	12.83	12	37505	1820	79705051
Platelet count decreased	20.36	12.83	159	37358	194505	79512366
Blood cholesterol increased	20.31	12.83	7	37510	83713	79623158
Drug reaction with eosinophilia and systemic symptoms	20.30	12.83	3	37514	64241	79642630
Epidermal necrosis	19.80	12.83	11	37506	1506	79705365
Nasopharyngitis	19.59	12.83	58	37459	253823	79453048
Adrenocortical carcinoma	19.55	12.83	5	37512	74	79706797
Clostridium difficile infection	19.51	12.83	54	37463	42631	79664240
Splenomegaly	19.46	12.83	35	37482	20719	79686152
Hypophagia	19.38	12.83	56	37461	45311	79661560
Posterior reversible encephalopathy syndrome	19.34	12.83	40	37477	26241	79680630
Lymphoproliferative disorder	19.19	12.83	18	37499	5597	79701274
Chest discomfort	19.16	12.83	22	37495	138022	79568849
Human anaplasmosis	19.13	12.83	5	37512	81	79706790
Myocardial infarction	19.05	12.83	36	37481	184093	79522778
Lower respiratory tract infection fungal	19.05	12.83	9	37508	879	79705992
Human metapneumovirus test positive	18.88	12.83	6	37511	199	79706672
Influenza B virus test positive	18.82	12.83	7	37510	375	79706496
Hip deformity	18.77	12.83	6	37511	203	79706668
Systemic mycosis	18.66	12.83	13	37504	2653	79704218
Staphylococcal infection	18.53	12.83	65	37452	58230	79648641
Small intestinal obstruction	18.32	12.83	40	37477	27232	79679639
Mixed anxiety and depressive disorder	18.29	12.83	7	37510	406	79706465
Overgrowth fungal	18.28	12.83	5	37512	97	79706774
Transverse sinus thrombosis	18.25	12.83	8	37509	657	79706214
Meningitis enterococcal	18.23	12.83	5	37512	98	79706773
Wrong technique in product usage process	18.23	12.83	6	37511	73869	79633002
Listeriosis	18.20	12.83	12	37505	2238	79704633
Bone marrow disorder	18.18	12.83	14	37503	3329	79703542
Oral herpes	18.14	12.83	40	37477	27414	79679457
Gastrointestinal inflammation	18.13	12.83	20	37497	7524	79699347
Blood pressure fluctuation	18.11	12.83	71	37446	67074	79639797
Electrocardiogram QT prolonged	18.06	12.83	10	37507	90376	79616495
Drug hypersensitivity	17.92	12.83	76	37441	298840	79408031
Cell death	17.88	12.83	16	37501	4683	79702188
Facial paralysis	17.83	12.83	34	37483	21038	79685833
Multiple organ dysfunction syndrome	17.80	12.83	107	37410	120139	79586732
Hepatic enzyme increased	17.78	12.83	37	37480	182573	79524298
Anaemia	17.75	12.83	301	37216	444714	79262157
Urticaria	17.63	12.83	38	37479	185163	79521708
Disease recurrence	17.46	12.83	53	37464	44056	79662815
Overdose	17.37	12.83	38	37479	184168	79522703
Disseminated cytomegaloviral infection	17.34	12.83	7	37510	468	79706403
Porphyria non-acute	17.33	12.83	8	37509	741	79706130
Herpes zoster meningoencephalitis	17.21	12.83	8	37509	753	79706118
Post lumbar puncture syndrome	17.17	12.83	8	37509	757	79706114
Functional gastrointestinal disorder	17.06	12.83	16	37501	4974	79701897
Antithrombin III decreased	16.99	12.83	7	37510	493	79706378
Therapeutic product effect decreased	16.98	12.83	32	37485	163831	79543040
Differentiation syndrome	16.95	12.83	12	37505	2512	79704359
Wheezing	16.84	12.83	18	37499	116646	79590225
Eosinophilic pneumonia chronic	16.75	12.83	7	37510	511	79706360
Encopresis	16.71	12.83	5	37512	135	79706736
Tonsil cancer	16.71	12.83	9	37508	1159	79705712
Toe walking	16.69	12.83	3	37514	6	79706865
Jaundice	16.54	12.83	59	37458	53290	79653581
Malignant neoplasm progression	16.47	12.83	24	37493	135966	79570905
Sleep disorder	16.38	12.83	10	37507	85667	79621204
Cutaneous leishmaniasis	16.35	12.83	6	37511	309	79706562
Haematocolpos	16.34	12.83	4	37513	49	79706822
Haematochezia	16.32	12.83	83	37434	87562	79619309
Rectal abscess	16.29	12.83	11	37506	2134	79704737
Pancreatitis necrotising	16.26	12.83	14	37503	3894	79702977
Cardiac failure	16.26	12.83	30	37487	154812	79552059
Disseminated trichosporonosis	16.12	12.83	5	37512	153	79706718
Magnetic resonance imaging head abnormal	16.12	12.83	12	37505	2714	79704157
Vascular access complication	16.12	12.83	11	37506	2171	79704700
Gastrointestinal haemorrhage	16.07	12.83	28	37489	147691	79559180
Metastases to pancreas	15.99	12.83	7	37510	573	79706298
Stomatitis	15.97	12.83	121	37396	146636	79560235
Rhabdomyolysis	15.93	12.83	15	37502	103116	79603755
Blood growth hormone decreased	15.65	12.83	4	37513	59	79706812
Enterocolitis infectious	15.57	12.83	12	37505	2857	79704014
Blister	15.56	12.83	20	37497	119456	79587415
Anaemia megaloblastic	15.38	12.83	7	37510	628	79706243
Eye opacity	15.37	12.83	3	37514	11	79706860
Hyperhidrosis	15.34	12.83	30	37487	151462	79555409
Autoimmune lymphoproliferative syndrome	15.24	12.83	5	37512	184	79706687
Acute lymphocytic leukaemia	15.22	12.83	15	37502	4954	79701917
Steatohepatitis	15.22	12.83	8	37509	982	79705889
Respiratory distress	15.18	12.83	61	37456	58278	79648593
Pericardial cyst	15.16	12.83	3	37514	12	79706859
West Nile viral infection	15.12	12.83	8	37509	994	79705877
Cardiac disorder	15.10	12.83	6	37511	65751	79641120
Placental transfusion syndrome	15.07	12.83	4	37513	69	79706802
Oesophageal mass	15.07	12.83	4	37513	69	79706802
Paraplegia	15.01	12.83	15	37502	5038	79701833
Multiple lentigines syndrome	14.96	12.83	5	37512	195	79706676
Melaena	14.93	12.83	5	37512	60885	79645986
Faecal calprotectin abnormal	14.86	12.83	5	37512	199	79706672
Mucoepidermoid carcinoma	14.80	12.83	4	37513	74	79706797
Mucous stools	14.74	12.83	15	37502	5147	79701724
Stomatitis necrotising	14.72	12.83	5	37512	205	79706666
Acute myocardial infarction	14.72	12.83	9	37508	77027	79629844
Dysplastic naevus syndrome	14.62	12.83	3	37514	15	79706856
Anorectal infection	14.51	12.83	6	37511	426	79706445
Bacteraemia	14.49	12.83	41	37476	32783	79674088
Lennox-Gastaut syndrome	14.45	12.83	5	37512	217	79706654
Dry skin	14.36	12.83	7	37510	67988	79638883
Dyspepsia	14.36	12.83	18	37499	108669	79598202
Enterocolitis	14.28	12.83	25	37492	14487	79692384
Memory impairment	14.25	12.83	19	37498	111715	79595156
Drug level above therapeutic	14.22	12.83	19	37498	8704	79698167
Pseudopolyp	14.16	12.83	6	37511	453	79706418
Red blood cell microcytes present	14.16	12.83	3	37514	18	79706853
Hepatic infection fungal	14.11	12.83	5	37512	233	79706638
Gastrointestinal sounds abnormal	14.10	12.83	15	37502	5420	79701451
Hyperglycaemia	14.09	12.83	68	37449	70267	79636604
Listeria sepsis	14.08	12.83	7	37510	765	79706106
Aplastic anaemia	14.06	12.83	28	37489	17877	79688994
Intestinal dilatation	14.02	12.83	11	37506	2689	79704182
Pulmonary mucormycosis	14.00	12.83	8	37509	1157	79705714
Pneumonia aspiration	13.98	12.83	7	37510	66960	79639911
Ocular icterus	13.95	12.83	15	37502	5485	79701386
Bilirubin conjugated increased	13.86	12.83	15	37502	5524	79701347
Mucocutaneous candidiasis	13.86	12.83	4	37513	95	79706776
Immunosuppression	13.84	12.83	23	37494	12780	79694091
Partial seizures	13.80	12.83	19	37498	8959	79697912
Eosinophilic bronchitis	13.76	12.83	6	37511	486	79706385
Blood immunoglobulin G decreased	13.76	12.83	12	37505	3397	79703474
Anaemia macrocytic	13.73	12.83	15	37502	5582	79701289
Agitation	13.71	12.83	16	37501	99699	79607172
Epstein-Barr viraemia	13.70	12.83	10	37507	2195	79704676
Respiratory arrest	13.64	12.83	5	37512	57545	79649326
Fistula of small intestine	13.62	12.83	7	37510	820	79706051
Ill-defined disorder	13.59	12.83	7	37510	65868	79641003
Superinfection	13.56	12.83	14	37503	4888	79701983
Epstein Barr virus positive mucocutaneous ulcer	13.56	12.83	7	37510	828	79706043
Injury	13.53	12.83	10	37507	77486	79629385
Papulopustular rosacea	13.41	12.83	3	37514	24	79706847
Dry mouth	13.36	12.83	13	37504	88006	79618865
Inappropriate schedule of product administration	13.33	12.83	108	37409	133520	79573351
Staphylococcal bacteraemia	13.28	12.83	22	37495	12196	79694675
Blood glucose increased	13.24	12.83	21	37496	114954	79591917
Ewing's sarcoma	13.19	12.83	3	37514	26	79706845
Bone marrow necrosis	13.18	12.83	5	37512	283	79706588
Adenovirus infection	13.17	12.83	18	37499	8429	79698442
Furuncle	13.16	12.83	17	37500	7537	79699334
Systemic candida	13.14	12.83	16	37501	6690	79700181
Chills	13.13	12.83	124	37393	160110	79546761
Acute kidney injury	13.12	12.83	169	37348	519235	79187636
Pneumococcal bacteraemia	13.07	12.83	4	37513	117	79706754
Leukaemia	13.03	12.83	15	37502	5910	79700961
Adrenal insufficiency	12.98	12.83	36	37481	28451	79678420
Contusion	12.97	12.83	32	37485	148744	79558127
Viral myelitis	12.94	12.83	4	37513	121	79706750
Depersonalisation/derealisation disorder	12.84	12.83	9	37508	1853	79705018

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01BB02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Purine analogues
CHEBI has role	CHEBI:35221	antimetabolite
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:149553	anticoronaviral drug
MeSH PA	D000963	Antimetabolites
MeSH PA	D000964	Antimetabolites, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
MeSH PA	D009676	Noxae
MeSH PA	D019384	Nucleic Acid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute lymphoid leukemia	indication	91857003	DOID:9952
Acute promyelocytic leukemia, FAB M3	indication	110004001
Psoriasis with arthropathy	off-label use	33339001
Crohn's disease	off-label use	34000006
Ulcerative colitis	off-label use	64766004	DOID:8577
Acute myeloid leukemia, disease	off-label use	91861009
Polycythemia vera	off-label use	109992005
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Obstruction of bile duct	contraindication	30144000
Dehydration	contraindication	34095006
Gastrointestinal ulcer	contraindication	40845000
Leukopenia	contraindication	84828003	DOID:615
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001
Acute pancreatitis	contraindication	197456007	DOID:2913
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Ascites	contraindication	389026000
Breastfeeding (mother)	contraindication	413712001
Hepatosplenic T-cell lymphoma	contraindication	445406001
Chemotherapy-Induced Hyperuricemia	contraindication
Thiopurine S-Methyltransferase Deficiency	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.99	acidic
pKa2	10.76	acidic
pKa3	3.37	Basic
pKa4	1.4	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Amidophosphoribosyltransferase	Enzyme	Q06203	PUR1_HUMAN	INHIBITOR				DRUGBANK	CHEMBL
Multidrug resistance-associated protein 5	Transporter	O15440	MRP5_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 4	Transporter	O15439	MRP4_HUMAN					WOMBAT-PK
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	4.79		DRUG MATRIX
Thiopurine S-methyltransferase	Enzyme	P51580	TPMT_HUMAN					WOMBAT-PK
Purine nucleoside phosphorylase	Enzyme	P00491	PNPH_HUMAN					WOMBAT-PK
Purine nucleoside phosphorylase	Enzyme		PUNA_MYCTU		Kd	4.10		CHEMBL

External reference:

ID	Source
4018776	VUID
N0000147079	NUI
D00161	KEGG_DRUG
4018776	VANDF
C0000618	UMLSCUI
CHEBI:50667	CHEBI
PM6	PDB_CHEM_ID
CHEMBL1425	ChEMBL_ID
CHEMBL1200751	ChEMBL_ID
DB01033	DRUGBANK_ID
D015122	MESH_DESCRIPTOR_UI
667490	PUBCHEM_CID
7226	IUPHAR_LIGAND_ID
E7WED276I5	UNII
103	RXNORM
3886	MMSL
48948	MMSL
5052	MMSL
NOCODE	MMSL
d00289	MMSL
002647	NDDF
1039008	SNOMEDCT_US
386835005	SNOMEDCT_US
6112-76-1	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	0054-4581	TABLET	50 mg	ORAL	ANDA	29 sections
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3547	TABLET	50 mg	ORAL	ANDA	29 sections
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3547	TABLET	50 mg	ORAL	ANDA	29 sections
mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	49884-922	TABLET	50 mg	ORAL	ANDA	24 sections
mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5282	TABLET	50 mg	ORAL	ANDA	24 sections
PURINETHOL	HUMAN PRESCRIPTION DRUG LABEL	1	60763-601	TABLET	50 mg	ORAL	NDA	30 sections
PURIXAN	HUMAN PRESCRIPTION DRUG LABEL	1	62484-0020	SUSPENSION	20 mg	ORAL	NDA	19 sections
PURIXAN	HUMAN PRESCRIPTION DRUG LABEL	1	62484-0020	SUSPENSION	20 mg	ORAL	NDA	19 sections
Mercaptopurine	HUMAN PRESCRIPTION DRUG LABEL	1	69076-913	TABLET	50 mg	ORAL	NDA authorized generic	31 sections