mercaptopurine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
aptamers, classical and mirror ones 1708 50-44-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mercaptopurine monohydrate
  • 6-mercaptopurine monohydrate
  • 6-mercaptopurine
  • xaluprine
  • mercaptopurine
  • mercapurin
  • purimethol
  • purinethiol
  • purinethol
  • thiohypoxanthine
  • mercaptopurine hydrate
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
  • Molecular weight: 152.18
  • Formula: C5H4N4S
  • CLOGP: -1.33
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 53.07
  • ALOGS: -2.32
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 16.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 12 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.18 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class AAK1,ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,CLK4,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,IRAK1,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MELK,MET,MKNK2,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDPK1,PIK3CD,PIM2,PRKAA1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 68
kinase-selectivity-class AAK1,AURKA,AURKB,BRAF,CDK9,CHEK1,DYRK1B,GRK2,GRK3,HASPIN,JAK1,MAP2K3,MAP3K10,MAP3K21,MAPK1,PDK1,PRKAA2,PRKACA,ROCK1,SGK1 20
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 11, 1953 FDA STASON PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1254.37 15.34 676 23301 157673 90446797
Febrile bone marrow aplasia 290.81 15.34 106 23871 9632 90594838
Venoocclusive liver disease 279.30 15.34 91 23886 5902 90598568
Crohn's disease 231.50 15.34 75 23902 4776 90599694
Pancytopenia 230.23 15.34 216 23761 120047 90484423
Neurotoxicity 150.80 15.34 85 23892 21382 90583088
Hypertriglyceridaemia 150.43 15.34 62 23915 7827 90596643
Temporal lobe epilepsy 143.33 15.34 31 23946 394 90604076
Acute lymphocytic leukaemia recurrent 141.85 15.34 45 23932 2676 90601794
Rhinovirus infection 138.42 15.34 54 23923 5909 90598561
Ileocaecal resection 135.26 15.34 31 23946 521 90603949
Hyperbilirubinaemia 133.97 15.34 68 23909 13868 90590602
Off label use 130.97 15.34 606 23371 1101646 89502824
Human bocavirus infection 118.30 15.34 27 23950 445 90604025
Haematotoxicity 117.11 15.34 60 23917 12475 90591995
Intestinal anastomosis 114.63 15.34 30 23947 892 90603578
Haemophagocytic lymphohistiocytosis 108.00 15.34 61 23916 15398 90589072
Abdominal pain 105.79 15.34 285 23692 395436 90209034
Pyrexia 105.41 15.34 398 23579 660087 89944383
Neutropenia 101.16 15.34 199 23778 224705 90379765
Myelosuppression 100.02 15.34 95 23882 53496 90550974
Pancreatitis 94.34 15.34 104 23873 69722 90534748
Joint swelling 90.21 15.34 13 23964 503287 90101183
Acute myeloid leukaemia 86.94 15.34 59 23918 20581 90583889
Neoplasm recurrence 84.53 15.34 32 23945 3227 90601243
Enterobacter infection 84.16 15.34 30 23947 2553 90601917
Secondary immunodeficiency 81.99 15.34 28 23949 2098 90602372
Enteritis 81.07 15.34 44 23933 10277 90594193
Perineal necrosis 80.91 15.34 16 23961 126 90604344
Bacterial infection 80.16 15.34 59 23918 23385 90581085
Gastroenteritis norovirus 78.95 15.34 28 23949 2348 90602122
Perineal infection 75.85 15.34 16 23961 179 90604291
Pneumatosis intestinalis 75.82 15.34 30 23947 3407 90601063
Colitis ulcerative 74.98 15.34 86 23891 60180 90544290
Pain 74.32 15.34 93 23884 996248 89608222
Hepatotoxicity 73.86 15.34 75 23902 45767 90558703
Herpes simplex 70.64 15.34 40 23937 10141 90594329
Hepatocellular injury 69.16 15.34 59 23918 28899 90575571
Human herpesvirus 6 infection 68.93 15.34 28 23949 3404 90601066
Synovitis 68.09 15.34 5 23972 329747 90274723
Alanine aminotransferase increased 67.39 15.34 116 23861 118222 90486248
Second primary malignancy 67.26 15.34 39 23938 10339 90594131
Leukaemia recurrent 67.22 15.34 22 23955 1445 90603025
Mucosal inflammation 66.30 15.34 79 23898 57546 90546924
Swelling 66.06 15.34 15 23962 419043 90185427
Bone marrow failure 65.66 15.34 60 23917 32161 90572309
Occupational asthma 65.54 15.34 14 23963 167 90604303
Drug specific antibody present 65.22 15.34 31 23946 5483 90598987
Sepsis 64.37 15.34 145 23832 179669 90424801
Myelodysplastic syndrome 63.47 15.34 49 23928 20854 90583616
Bacillus infection 63.27 15.34 19 23958 940 90603530
Ileal stenosis 63.07 15.34 24 23953 2454 90602016
Clostridium difficile colitis 62.94 15.34 54 23923 26652 90577818
Arthropathy 62.12 15.34 11 23966 366231 90238239
Venous thrombosis 62.06 15.34 30 23947 5507 90598963
Wound 61.40 15.34 5 23972 302975 90301495
Systemic lupus erythematosus 61.09 15.34 11 23966 361885 90242585
Abdominal discomfort 61.01 15.34 25 23952 477303 90127167
Coagulopathy 60.89 15.34 50 23927 23239 90581231
Peripheral swelling 60.84 15.34 17 23960 413089 90191381
Enterovirus test positive 58.81 15.34 13 23964 184 90604286
Glioma 57.97 15.34 15 23962 426 90604044
Colitis 57.18 15.34 81 23896 69861 90534609
Hepatosplenic T-cell lymphoma 55.90 15.34 16 23961 668 90603802
Hypoalbuminaemia 54.33 15.34 40 23937 15857 90588613
Fall 54.27 15.34 30 23947 481780 90122690
Hypoglycaemia 52.88 15.34 78 23899 69770 90534700
Device related infection 52.51 15.34 48 23929 25738 90578732
Glioblastoma multiforme 50.91 15.34 16 23961 922 90603548
Oesophageal dilatation 50.62 15.34 14 23963 515 90603955
Intestinal stenosis 50.04 15.34 22 23955 3252 90601218
Antithrombin III 49.74 15.34 11 23966 156 90604314
Bile acid malabsorption 48.51 15.34 12 23965 283 90604187
Psoriatic arthropathy 48.47 15.34 3 23974 228332 90376138
Pericarditis 48.30 15.34 7 23970 270144 90334326
Bacterial vulvovaginitis 47.84 15.34 15 23962 858 90603612
Trichodysplasia spinulosa 46.67 15.34 14 23963 690 90603780
Cystitis bacterial 46.43 15.34 12 23965 339 90604131
Partial seizures 46.30 15.34 27 23950 7233 90597237
Pancreatitis acute 45.39 15.34 49 23928 32066 90572404
Insomnia 45.02 15.34 16 23961 333458 90271012
Discomfort 44.88 15.34 9 23968 274326 90330144
Cholestasis 43.79 15.34 51 23926 36248 90568222
Rectal cancer metastatic 43.70 15.34 11 23966 279 90604191
Female sterilisation 42.77 15.34 13 23964 670 90603800
Perirectal abscess 42.35 15.34 14 23963 949 90603521
Dyspnoea 42.32 15.34 108 23869 880847 89723623
Epstein-Barr virus infection 42.21 15.34 29 23948 10315 90594155
Musculoskeletal stiffness 42.17 15.34 13 23964 296519 90307951
Leukoencephalopathy 41.71 15.34 22 23955 4851 90599619
Central obesity 41.00 15.34 15 23962 1375 90603095
Ileal ulcer 40.95 15.34 14 23963 1052 90603418
Blood culture positive 40.88 15.34 22 23955 5050 90599420
Mucormycosis 40.72 15.34 20 23957 3801 90600669
Clostridium difficile infection 40.55 15.34 49 23928 36196 90568274
Cervix carcinoma stage 0 40.49 15.34 12 23965 567 90603903
Histoplasmosis disseminated 40.19 15.34 17 23960 2288 90602182
Myelopathy 39.63 15.34 19 23958 3425 90601045
Lower respiratory tract infection 39.41 15.34 9 23968 250650 90353820
Confusional state 39.36 15.34 27 23950 386178 90218292
Venoocclusive disease 39.16 15.34 17 23960 2438 90602032
Segmental diverticular colitis 38.53 15.34 9 23968 165 90604305
Anal fistula 38.48 15.34 20 23957 4281 90600189
Osteoarthritis 37.59 15.34 4 23973 195726 90408744
Folliculitis 37.21 15.34 5 23972 204348 90400122
Leukopenia 36.89 15.34 82 23895 100628 90503842
Enterovirus infection 36.52 15.34 14 23963 1460 90603010
Cerebral venous sinus thrombosis 36.42 15.34 16 23961 2360 90602110
Volume blood decreased 36.35 15.34 9 23968 213 90604257
Rectal abscess 36.29 15.34 14 23963 1486 90602984
Pedal pulse abnormal 36.27 15.34 9 23968 215 90604255
Fistula 35.96 15.34 28 23949 12061 90592409
Seizure 35.81 15.34 105 23872 152524 90451946
Anal abscess 35.80 15.34 21 23956 5687 90598783
Blood cholesterol increased 35.79 15.34 6 23971 208006 90396464
Strongyloidiasis 35.39 15.34 14 23963 1588 90602882
Human rhinovirus test positive 35.24 15.34 12 23965 891 90603579
Staphylococcal sepsis 35.23 15.34 25 23952 9358 90595112
Gastrointestinal wall thickening 34.75 15.34 15 23962 2122 90602348
Death 34.55 15.34 42 23935 456509 90147961
Hyperglycaemia 34.44 15.34 54 23923 50916 90553554
Colostomy 34.40 15.34 13 23964 1304 90603166
Histoplasmosis 34.30 15.34 15 23962 2189 90602281
Overgrowth fungal 34.23 15.34 8 23969 147 90604323
Asthma 33.74 15.34 11 23966 242149 90362321
Vital capacity decreased 33.67 15.34 14 23963 1805 90602665
Blood bilirubin increased 33.55 15.34 49 23928 43421 90561049
Intestinal resection 33.23 15.34 16 23961 2911 90601559
Serum sickness 33.21 15.34 17 23960 3525 90600945
Painful respiration 32.77 15.34 16 23961 3002 90601468
Contusion 32.31 15.34 13 23964 251203 90353267
Drug level decreased 32.16 15.34 24 23953 9706 90594764
Calcium ionised decreased 31.84 15.34 9 23968 359 90604111
Pleuroparenchymal fibroelastosis 31.82 15.34 8 23969 202 90604268
Post lumbar puncture syndrome 31.44 15.34 11 23966 886 90603584
Social problem 31.35 15.34 12 23965 1247 90603223
Pseudomonas test positive 31.21 15.34 11 23966 905 90603565
Injury 31.19 15.34 7 23970 197342 90407128
Viral infection 30.98 15.34 46 23931 41368 90563102
Hepatic enzyme increased 30.81 15.34 30 23947 360706 90243764
Subacute combined cord degeneration 30.72 15.34 8 23969 233 90604237
Pruritus 30.33 15.34 61 23916 541464 90063006
Abdominal adhesions 30.29 15.34 16 23961 3539 90600931
Osteonecrosis 30.21 15.34 36 23941 26205 90578265
Blister 29.97 15.34 15 23962 254983 90349487
Aspergillus infection 29.90 15.34 24 23953 10799 90593671
Vocal cord paralysis 29.78 15.34 14 23963 2416 90602054
Stress urinary incontinence 29.66 15.34 14 23963 2438 90602032
Hypertransaminasaemia 29.41 15.34 28 23949 15797 90588673
Neutrophil count decreased 29.36 15.34 61 23916 71471 90532999
Mobility decreased 29.09 15.34 15 23962 250719 90353751
Porphyria non-acute 28.91 15.34 8 23969 295 90604175
Superior sagittal sinus thrombosis 28.70 15.34 10 23967 796 90603674
Gamma-glutamyltransferase increased 28.17 15.34 42 23935 37910 90566560
Mucosal disorder 28.03 15.34 14 23963 2757 90601713
Irritable bowel syndrome 27.90 15.34 10 23967 207438 90397032
Lymphoproliferative disorder 27.57 15.34 16 23961 4246 90600224
Epstein Barr virus positive mucocutaneous ulcer 27.56 15.34 9 23968 587 90603883
Acute lymphocytic leukaemia refractory 27.47 15.34 6 23971 80 90604390
Pseudomonal sepsis 27.43 15.34 16 23961 4286 90600184
Fatigue 27.43 15.34 186 23791 1153837 89450633
Escherichia infection 27.42 15.34 27 23950 15868 90588602
Picornavirus infection 27.34 15.34 6 23971 82 90604388
Appendicectomy 27.32 15.34 15 23962 3581 90600889
Faecal calprotectin abnormal 27.15 15.34 7 23970 196 90604274
Jaundice 27.07 15.34 38 23939 32479 90571991
Pneumonia fungal 27.02 15.34 19 23958 7012 90597458
Cytomegalovirus infection 26.61 15.34 34 23943 26568 90577902
Feeding intolerance 26.45 15.34 10 23967 1004 90603466
Ileostomy 26.26 15.34 12 23965 1942 90602528
Encopresis 25.90 15.34 6 23971 106 90604364
Chloroma 25.43 15.34 7 23970 253 90604217
Drug hypersensitivity 25.29 15.34 53 23924 463556 90140914
Rhinocerebral mucormycosis 24.83 15.34 9 23968 803 90603667
Drug interaction 24.79 15.34 141 23836 276312 90328158
Inflammatory bowel disease 24.72 15.34 16 23961 5155 90599315
Enterobacter bacteraemia 24.68 15.34 9 23968 817 90603653
Glossitis 24.63 15.34 14 23963 3573 90600897
Influenza B virus test positive 24.62 15.34 7 23970 285 90604185
Intestinal dilatation 24.34 15.34 12 23965 2298 90602172
Dyspepsia 24.29 15.34 11 23966 198149 90406321
Enterocolitis 24.28 15.34 21 23956 10469 90594001
Small intestinal obstruction 24.23 15.34 29 23948 21205 90583265
Aborted pregnancy 24.21 15.34 5 23972 50 90604420
Hypophagia 24.17 15.34 38 23939 35899 90568571
Hepatosplenomegaly 24.11 15.34 13 23964 2996 90601474
Cytogenetic abnormality 24.09 15.34 8 23969 550 90603920
Gastrointestinal sounds abnormal 24.07 15.34 15 23962 4528 90599942
Rash 23.86 15.34 119 23858 795981 89808489
Metastases to pancreas 23.59 15.34 7 23970 332 90604138
Large intestinal stenosis 23.46 15.34 12 23965 2485 90601985
Sinusitis 23.45 15.34 34 23943 343054 90261416
Breakthrough pain 23.28 15.34 10 23967 1397 90603073
Erythema nodosum 23.24 15.34 16 23961 5708 90598762
Hepatic infection fungal 23.23 15.34 5 23972 62 90604408
Escherichia bacteraemia 23.21 15.34 16 23961 5719 90598751
Gallbladder enlargement 23.16 15.34 9 23968 974 90603496
Toe walking 22.94 15.34 4 23973 14 90604456
Dry mouth 22.90 15.34 10 23967 184049 90420421
Acute motor-sensory axonal neuropathy 22.90 15.34 7 23970 368 90604102
Cardiotoxicity 22.79 15.34 21 23956 11368 90593102
Alopecia 22.71 15.34 62 23915 495009 90109461
Blood pressure abnormal 22.70 15.34 27 23950 19618 90584852
Cushingoid 22.44 15.34 20 23957 10375 90594095
Urticaria 22.36 15.34 30 23947 312704 90291766
Drug ineffective 22.28 15.34 500 23477 1383798 89220672
Epstein-Barr virus associated lymphoma 22.22 15.34 8 23969 700 90603770
Haemolytic uraemic syndrome 22.12 15.34 12 23965 2799 90601671
Herpes zoster meningoencephalitis 22 15.34 7 23970 420 90604050
Drug resistance 21.60 15.34 33 23944 30416 90574054
Posterior reversible encephalopathy syndrome 21.48 15.34 28 23949 22311 90582159
Depression 21.33 15.34 29 23948 300572 90303898
Respiratory tract haemorrhage 21.30 15.34 7 23970 466 90604004
Lipase increased 21.30 15.34 20 23957 11091 90593379
T-cell lymphoma 21.29 15.34 8 23969 790 90603680
Norovirus test positive 21.28 15.34 6 23971 237 90604233
Anaemia megaloblastic 21.21 15.34 7 23970 472 90603998
Joint range of motion decreased 21.05 15.34 5 23972 135638 90468832
Bronchitis chronic 21.03 15.34 14 23963 4729 90599741
Haematochezia 20.83 15.34 53 23924 70860 90533610
Intracranial pressure increased 20.75 15.34 16 23961 6795 90597675
Ocular icterus 20.73 15.34 13 23964 3967 90600503
Disseminated trichosporonosis 20.67 15.34 5 23972 107 90604363
Impaired healing 20.54 15.34 19 23958 234180 90370290
Meningitis coccidioides 20.52 15.34 4 23973 29 90604441
West Nile viral infection 20.50 15.34 7 23970 524 90603946
Chills 20.46 15.34 79 23898 131902 90472568
Functional gastrointestinal disorder 20.20 15.34 14 23963 5048 90599422
Nasopharyngitis 20.19 15.34 49 23928 407055 90197415
Proctalgia 20.18 15.34 17 23960 8181 90596289
Lung opacity 20.06 15.34 15 23962 6087 90598383
Granulomatous liver disease 19.94 15.34 8 23969 941 90603529
Escherichia test positive 19.91 15.34 11 23966 2659 90601811
Perineal pain 19.86 15.34 7 23970 576 90603894
Migraine 19.79 15.34 13 23964 190379 90414091
Platelet count decreased 19.63 15.34 80 23897 136889 90467581
Transverse sinus thrombosis 19.47 15.34 7 23970 610 90603860
Staphylococcal bacteraemia 19.44 15.34 16 23961 7453 90597017
Respiratory distress 19.35 15.34 36 23941 38910 90565560
Furuncle 19.27 15.34 16 23961 7545 90596925
Acute lymphocytic leukaemia 19.25 15.34 11 23966 2837 90601633
Intestinal fistula 19.18 15.34 8 23969 1039 90603431
Dizziness 18.85 15.34 86 23891 589198 90015272
Appendicitis 18.82 15.34 18 23959 10213 90594257
Depersonalisation/derealisation disorder 18.77 15.34 9 23968 1623 90602847
Musculoskeletal pain 18.76 15.34 11 23966 171240 90433230
Splenomegaly 18.75 15.34 20 23957 12904 90591566
Pulmonary granuloma 18.66 15.34 9 23968 1644 90602826
Mucoepidermoid carcinoma 18.63 15.34 4 23973 49 90604421
Bone marrow disorder 18.61 15.34 11 23966 3021 90601449
Oesophageal mass 18.55 15.34 4 23973 50 90604420
Alopecia universalis 18.49 15.34 5 23972 169 90604301
Malaise 18.45 15.34 86 23891 585900 90018570
Wound infection 18.45 15.34 3 23974 106399 90498071
Intracardiac thrombus 18.31 15.34 10 23967 2364 90602106
Bilirubin conjugated increased 18.28 15.34 11 23966 3119 90601351
Pseudopolyp 18.27 15.34 6 23971 398 90604072
Aplasia 18.23 15.34 12 23965 3979 90600491
Diarrhoea haemorrhagic 18.19 15.34 18 23959 10645 90593825
Cerebral ischaemia 17.87 15.34 15 23962 7181 90597289
Terminal ileitis 17.82 15.34 8 23969 1242 90603228
Haematocolpos 17.82 15.34 4 23973 61 90604409
Disease recurrence 17.71 15.34 34 23943 37619 90566851
Lung infiltration 17.65 15.34 21 23956 15261 90589209
General physical health deterioration 17.40 15.34 43 23934 355072 90249398
Acute myelomonocytic leukaemia 17.24 15.34 5 23972 219 90604251
Anal fissure 17.17 15.34 13 23964 5372 90599098
Fungal infection 17.06 15.34 36 23941 42625 90561845
Drug metabolite level high 16.89 15.34 3 23974 12 90604458
Pericardial cyst 16.70 15.34 3 23974 13 90604457
Oedema 16.69 15.34 17 23960 200278 90404192
Histiocytic sarcoma 16.66 15.34 4 23973 83 90604387
Pulmonary fibrosis 16.61 15.34 4 23973 107499 90496971
Respiratory syncytial virus infection 16.61 15.34 17 23960 10463 90594007
Neuropathy peripheral 16.56 15.34 76 23901 136894 90467576
Tachycardia 16.55 15.34 84 23893 157589 90446881
Coagulation factor VII level decreased 16.52 15.34 4 23973 86 90604384
Enterobacter test positive 16.43 15.34 5 23972 259 90604211
Gambling 16.39 15.34 5 23972 261 90604209
Atypical haemolytic uraemic syndrome 16.26 15.34 7 23970 984 90603486
Lower respiratory tract infection fungal 16.24 15.34 5 23972 269 90604201
Quadriplegia 16.11 15.34 9 23968 2222 90602248
Amylase increased 16.05 15.34 14 23963 7058 90597412
Cerebral haemangioma 16.02 15.34 4 23973 98 90604372
Type IV hypersensitivity reaction 16 15.34 11 23966 3915 90600555
Lupus-like syndrome 15.92 15.34 38 23939 48808 90555662
Hippocampal sclerosis 15.91 15.34 4 23973 101 90604369
Thrombocytopenia 15.86 15.34 102 23875 208623 90395847
Cryptococcal fungaemia 15.72 15.34 4 23973 106 90604364
Lennox-Gastaut syndrome 15.71 15.34 5 23972 300 90604170
Ileectomy 15.65 15.34 5 23972 304 90604166
Atrial fibrillation 15.48 15.34 8 23969 133603 90470867
Cytopenia 15.44 15.34 21 23956 17428 90587042

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1365.34 14.80 1024 24825 184679 42410807
Myelosuppression 312.31 14.80 231 25618 40230 42555256
Hepatosplenic T-cell lymphoma 256.92 14.80 60 25789 446 42595040
Venoocclusive liver disease 223.52 14.80 114 25735 10188 42585298
Hypertriglyceridaemia 199.42 14.80 105 25744 10021 42585465
Haematotoxicity 191.39 14.80 105 25744 10880 42584606
Febrile bone marrow aplasia 190.42 14.80 102 25747 10079 42585407
Death 164.39 14.80 42 25807 471143 42124343
Hepatotoxicity 151.25 14.80 124 25725 25043 42570443
Acute lymphocytic leukaemia recurrent 133.07 14.80 58 25791 3633 42591853
Pancreatitis 129.38 14.80 145 25704 43123 42552363
Leukoencephalopathy 122.72 14.80 60 25789 4894 42590592
Pyrexia 122.45 14.80 517 25332 393525 42201961
Pancytopenia 120.46 14.80 238 25611 117505 42477981
Neutropenia 115.03 14.80 322 25527 199109 42396377
Glioma 103.23 14.80 29 25820 477 42595009
Bone marrow failure 99.07 14.80 111 25738 32982 42562504
Mucosal inflammation 89.54 14.80 129 25720 49245 42546241
Osteonecrosis 88.71 14.80 75 25774 15790 42579696
Colitis 87.86 14.80 124 25725 46448 42549038
Glioblastoma multiforme 87.35 14.80 29 25820 853 42594633
Cytomegalovirus chorioretinitis 85.65 14.80 46 25803 4565 42590921
Crohn's disease 82.58 14.80 39 25810 2945 42592541
Haemophagocytic lymphohistiocytosis 77.84 14.80 74 25775 18148 42577338
Multiple-drug resistance 73.13 14.80 49 25800 7273 42588213
Second primary malignancy 70.05 14.80 53 25796 9522 42585964
Venoocclusive disease 69.77 14.80 38 25811 3877 42591609
Abdominal pain 67.67 14.80 261 25588 190210 42405276
Nodular regenerative hyperplasia 67.45 14.80 25 25824 1023 42594463
Acute myeloid leukaemia 67.19 14.80 75 25774 22181 42573305
Off label use 66.57 14.80 633 25216 637702 41957784
Hyperbilirubinaemia 63.09 14.80 70 25779 20565 42574921
Colitis ulcerative 62.12 14.80 78 25771 26097 42569389
Enterovirus infection 58.90 14.80 24 25825 1269 42594217
Fall 56.99 14.80 36 25813 234484 42361002
Neurotoxicity 56.96 14.80 71 25778 23580 42571906
Drug clearance decreased 55.81 14.80 27 25822 2151 42593335
Atrial fibrillation 55.60 14.80 9 25840 139584 42455902
Dyspnoea 53.89 14.80 118 25731 442503 42152983
Hypertransaminasaemia 52.36 14.80 44 25805 9183 42586303
Myocardial infarction 51.68 14.80 7 25842 124002 42471484
Lentigo 50.41 14.80 19 25830 815 42594671
Portal hypertension 50.13 14.80 33 25816 4754 42590732
Epstein-Barr virus associated lymphoproliferative disorder 49.98 14.80 26 25823 2417 42593069
Pancreatitis acute 49.92 14.80 80 25769 33484 42562002
HCoV-HKU1 infection 48.42 14.80 10 25839 38 42595448
Myelodysplastic syndrome 48.06 14.80 64 25785 22681 42572805
Leukaemia recurrent 47.30 14.80 23 25826 1853 42593633
Human rhinovirus test positive 46.76 14.80 14 25835 291 42595195
Dizziness 46.05 14.80 50 25799 249204 42346282
Stomatitis 45.76 14.80 97 25752 50232 42545254
Parainfluenzae virus infection 45.33 14.80 28 25821 3615 42591871
Gallbladder oedema 44.92 14.80 13 25836 239 42595247
Gastrointestinal wall thickening 44.73 14.80 22 25827 1817 42593669
Epstein-Barr virus infection 44.44 14.80 41 25808 9677 42585809
Fibrinous bronchitis 43.66 14.80 11 25838 116 42595370
Intracranial pressure increased 43.63 14.80 30 25819 4644 42590842
Inflammatory bowel disease 43.60 14.80 27 25822 3502 42591984
Thrombocytopenia 42.90 14.80 228 25621 190051 42405435
Aspergillus infection 42.12 14.80 50 25799 15787 42579699
Histoplasmosis disseminated 42.05 14.80 22 25827 2069 42593417
Frequent bowel movements 41.84 14.80 58 25791 21349 42574137
Cytogenetic abnormality 41.45 14.80 17 25832 914 42594572
Lip scab 41.42 14.80 10 25839 87 42595399
Ileal stenosis 41.29 14.80 21 25828 1863 42593623
Depression 40.47 14.80 9 25840 111354 42484132
Cardiac failure congestive 40.41 14.80 3 25846 85599 42509887
Angiolymphoid hyperplasia with eosinophilia 37.78 14.80 10 25839 130 42595356
B-cell lymphoma 37.72 14.80 28 25821 4885 42590601
Pneumocystis jirovecii pneumonia 37.41 14.80 60 25789 25121 42570365
Rhinovirus infection 36.69 14.80 31 25818 6517 42588969
Steatohepatitis 36.60 14.80 13 25836 470 42595016
Intestinal stenosis 36.03 14.80 22 25827 2782 42592704
Leukopenia 35.63 14.80 113 25736 74633 42520853
Enterovirus test positive 35.63 14.80 9 25840 96 42595390
Haematopoietic neoplasm 35.59 14.80 8 25841 49 42595437
Neutropenic colitis 35.50 14.80 26 25823 4444 42591042
Neutrophil count decreased 35.05 14.80 101 25748 63314 42532172
Hyperkalaemia 34.83 14.80 4 25845 80454 42515032
Colectomy 34.43 14.80 20 25829 2309 42593177
Diffuse large B-cell lymphoma 34.07 14.80 35 25814 9419 42586067
Alanine aminotransferase increased 33.68 14.80 124 25725 88282 42507204
Cytopenia 33.58 14.80 47 25802 17450 42578036
Fistula 33.53 14.80 32 25817 7880 42587606
Candida endophthalmitis 32.50 14.80 9 25840 140 42595346
Mixed anxiety and depressive disorder 32.32 14.80 10 25839 233 42595253
Sepsis 32.20 14.80 219 25630 199115 42396371
Product dose omission issue 31.91 14.80 28 25821 154337 42441149
Otitis media acute 31.87 14.80 13 25836 689 42594797
Acute monocytic leukaemia 31.07 14.80 11 25838 394 42595092
Myelopathy 30.44 14.80 20 25829 2871 42592615
Hepatic steatosis 30.36 14.80 50 25799 21398 42574088
Proctitis 30.18 14.80 20 25829 2913 42592573
Picornavirus infection 29.97 14.80 7 25842 52 42595434
Vomiting 29.77 14.80 287 25562 289436 42306050
Pneumonia fungal 29.64 14.80 32 25817 9114 42586372
Peripheral swelling 29.54 14.80 9 25840 90261 42505225
Superior sagittal sinus thrombosis 28.94 14.80 10 25839 333 42595153
Gastrointestinal dilation procedure 28.81 14.80 6 25843 24 42595462
Somnolence 28.67 14.80 26 25823 141079 42454407
Asthenia 28.52 14.80 82 25767 280711 42314775
Angiocentric lymphoma 28.05 14.80 11 25838 526 42594960
Hepatocellular injury 28.02 14.80 51 25798 23627 42571859
Chronic obstructive pulmonary disease 27.66 14.80 3 25846 63111 42532375
Pneumonia viral 27.65 14.80 22 25827 4252 42591234
Cardiac arrest 27.60 14.80 16 25833 109304 42486182
Xanthogranuloma 27.60 14.80 7 25842 76 42595410
Dystrophic calcification 27.40 14.80 6 25843 32 42595454
Juvenile chronic myelomonocytic leukaemia 27.40 14.80 6 25843 32 42595454
Mucormycosis 26.75 14.80 27 25822 7116 42588370
Neoplasm recurrence 26.65 14.80 18 25831 2706 42592780
Respiratory syncytial virus test positive 26.46 14.80 10 25839 432 42595054
Confusional state 26.34 14.80 38 25811 167559 42427927
General physical health deterioration 26.10 14.80 32 25817 151214 42444272
Gastroenteritis rotavirus 25.46 14.80 9 25840 321 42595165
Drug metabolite level high 25.38 14.80 5 25844 14 42595472
Scedosporium infection 24.69 14.80 14 25835 1544 42593942
Cytomegalovirus hepatitis 24.64 14.80 10 25839 523 42594963
Malignant neoplasm progression 24.47 14.80 18 25831 108382 42487104
Blood fibrinogen decreased 24.32 14.80 14 25835 1589 42593897
Anaemia megaloblastic 24.08 14.80 9 25840 377 42595109
Ileocaecal resection 23.47 14.80 9 25840 405 42595081
Proctalgia 23.31 14.80 25 25824 7068 42588418
Diarrhoea haemorrhagic 23.30 14.80 26 25823 7681 42587805
Anal abscess 22.91 14.80 26 25823 7824 42587662
Linitis plastica 22.86 14.80 4 25845 4 42595482
Pulmonary mucormycosis 22.86 14.80 13 25836 1442 42594044
Transaminases increased 22.83 14.80 57 25792 32828 42562658
Cytomegalovirus colitis 22.62 14.80 19 25830 3962 42591524
Posterior reversible encephalopathy syndrome 22.49 14.80 33 25816 12788 42582698
Cytomegalovirus infection 22.43 14.80 56 25793 32250 42563236
Adrenocortical carcinoma 22.33 14.80 5 25844 30 42595456
Oedema peripheral 22.22 14.80 30 25819 136046 42459440
Multiple lentigines syndrome 22.19 14.80 5 25844 31 42595455
Rhabdomyolysis 21.80 14.80 10 25839 78009 42517477
Small intestinal obstruction 21.80 14.80 38 25811 17023 42578463
Completed suicide 21.80 14.80 16 25833 96449 42499037
Acral lentiginous melanoma 21.79 14.80 5 25844 34 42595452
Pruritus 21.52 14.80 52 25797 188719 42406767
Systemic mycosis 21.52 14.80 15 25834 2372 42593114
Viral pharyngitis 21.41 14.80 7 25842 196 42595290
Neurological examination abnormal 21.38 14.80 8 25841 336 42595150
Steroid diabetes 21.33 14.80 16 25833 2836 42592650
Haemolytic uraemic syndrome 21.01 14.80 15 25834 2464 42593022
Autoimmune lymphoproliferative syndrome 20.95 14.80 7 25842 210 42595276
Mesenteritis 20.87 14.80 5 25844 42 42595444
Astrocytoma 20.86 14.80 7 25842 213 42595273
Atypical haemolytic uraemic syndrome 20.85 14.80 9 25840 550 42594936
Fatigue 20.78 14.80 167 25682 435474 42160012
Dysplastic naevus syndrome 20.63 14.80 4 25845 10 42595476
Rectal stenosis 20.61 14.80 7 25842 221 42595265
Body temperature increased 20.57 14.80 41 25808 20317 42575169
Syncope 20.57 14.80 18 25831 99388 42496098
Pneumonia toxoplasmal 20.36 14.80 5 25844 47 42595439
Cardiac iron overload 20.35 14.80 4 25845 11 42595475
Fungal infection 20.27 14.80 40 25809 19682 42575804
Faecal calprotectin increased 20.17 14.80 16 25833 3078 42592408
Lymphopenia 20.10 14.80 42 25807 21521 42573965
Septic shock 20.03 14.80 109 25740 91563 42503923
Thymus enlargement 19.99 14.80 5 25844 51 42595435
Minimal residual disease 19.94 14.80 9 25840 612 42594874
Staphylococcal sepsis 19.48 14.80 29 25820 11385 42584101
Magnetic resonance imaging head abnormal 19.38 14.80 12 25837 1555 42593931
Renal failure 19.38 14.80 36 25813 143690 42451796
Sleep disorder 19.36 14.80 3 25846 48092 42547394
Electrocardiogram QT prolonged 19.28 14.80 3 25846 47942 42547544
Device related bacteraemia 19.17 14.80 9 25840 670 42594816
Pseudomonal bacteraemia 19.17 14.80 14 25835 2382 42593104
Anamnestic reaction 19.03 14.80 5 25844 63 42595423
Chest pain 18.77 14.80 35 25814 139495 42455991
Muscle spasms 18.51 14.80 15 25834 86029 42509457
Drug specific antibody present 18.51 14.80 17 25832 3989 42591497
Metastases to rectum 18.48 14.80 4 25845 20 42595466
Intestinal diaphragm disease 18.44 14.80 7 25842 306 42595180
Ureteric obstruction 18.41 14.80 11 25838 1338 42594148
Insomnia 18.38 14.80 27 25822 118226 42477260
Hallucination 18.33 14.80 6 25843 57501 42537985
Cerebral venous sinus thrombosis 18.31 14.80 9 25840 742 42594744
Human anaplasmosis 18.29 14.80 5 25844 74 42595412
Abscess limb 18.18 14.80 17 25832 4080 42591406
Epstein-Barr virus associated lymphoma 18.04 14.80 10 25839 1056 42594430
Enteritis 17.77 14.80 27 25822 10789 42584697
Cytomegalovirus gastrointestinal infection 17.59 14.80 7 25842 348 42595138
Clostridium test positive 17.38 14.80 19 25830 5486 42590000
T-cell lymphoma 17.30 14.80 10 25839 1143 42594343
Tonsil cancer 17.24 14.80 10 25839 1151 42594335
Respiratory distress 17.05 14.80 60 25789 41760 42553726
Trichodysplasia spinulosa 16.90 14.80 7 25842 386 42595100
Human metapneumovirus test positive 16.88 14.80 5 25844 100 42595386
Therapeutic product effect decreased 16.68 14.80 57 25792 39093 42556393
Vascular access complication 16.66 14.80 7 25842 400 42595086
Haemophilus test positive 16.61 14.80 5 25844 106 42595380
Drug-induced liver injury 16.55 14.80 56 25793 38217 42557269
Anorectal cellulitis 16.35 14.80 4 25845 37 42595449
Jugular vein thrombosis 16.33 14.80 12 25837 2062 42593424
Tremor 16.20 14.80 21 25828 96908 42498578
Hip deformity 16.14 14.80 5 25844 117 42595369
Protein-losing gastroenteropathy 16.06 14.80 7 25842 438 42595048
Cardiac failure 16.02 14.80 25 25824 106831 42488655
Hyponatraemia 15.93 14.80 23 25826 101439 42494047
Hepatitis E 15.86 14.80 14 25835 3120 42592366
Cardiac disorder 15.78 14.80 5 25844 48927 42546559
Cutaneous leishmaniasis 15.77 14.80 6 25843 264 42595222
Petechiae 15.68 14.80 25 25824 10410 42585076
Blood glucose increased 15.66 14.80 13 25836 73686 42521800
Haemorrhagic diathesis 15.65 14.80 14 25835 3175 42592311
Intestinal anastomosis 15.58 14.80 7 25842 471 42595015
Campylobacter colitis 15.56 14.80 4 25845 46 42595440
Dry skin 15.48 14.80 5 25844 48333 42547153
Blood creatine phosphokinase increased 15.48 14.80 5 25844 48333 42547153
Abscess intestinal 15.47 14.80 11 25838 1795 42593691
Disseminated cytomegaloviral infection 15.46 14.80 6 25843 279 42595207
Acute myocardial infarction 15.42 14.80 8 25841 58157 42537329
Chronic hepatitis 15.35 14.80 8 25841 746 42594740
Neutrophil count abnormal 15.28 14.80 13 25836 2758 42592728
Chemotherapeutic drug level increased 15.14 14.80 6 25843 295 42595191
Eosinophilic pneumonia chronic 15.02 14.80 6 25843 301 42595185
Anxiety 14.86 14.80 31 25818 118529 42476957
Cryptococcus test positive 14.83 14.80 3 25846 10 42595476

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2616.48 13.75 1617 43689 315150 110228843
Secondary immunodeficiency 411.94 13.75 128 45178 4548 110539445
Myelosuppression 391.71 13.75 318 44988 94022 110449971
Pancytopenia 346.64 13.75 428 44878 209185 110334808
Haematotoxicity 324.75 13.75 163 45143 20919 110523074
Hypertriglyceridaemia 318.74 13.75 148 45158 16006 110527987
Bacterial infection 286.76 13.75 198 45108 45838 110498155
Rhinovirus infection 260.89 13.75 117 45189 11672 110532321
Febrile bone marrow aplasia 254.29 13.75 130 45176 17335 110526658
Hepatosplenic T-cell lymphoma 254.25 13.75 63 45243 944 110543049
Human bocavirus infection 247.16 13.75 63 45243 1065 110542928
Acute lymphocytic leukaemia recurrent 236.12 13.75 89 45217 5698 110538295
Hepatotoxicity 228.44 13.75 197 45109 63203 110480790
Neutropenia 218.55 13.75 477 44829 374143 110169850
Human herpesvirus 6 infection 197.38 13.75 81 45225 6500 110537493
Mycobacterium chelonae infection 196.90 13.75 66 45240 2994 110540999
Parainfluenzae virus infection 192.84 13.75 81 45225 6893 110537100
Norovirus test positive 192.17 13.75 50 45256 920 110543073
Pyrexia 190.52 13.75 799 44507 897466 109646527
Cystitis bacterial 188.68 13.75 52 45254 1201 110542792
Haemophagocytic lymphohistiocytosis 187.77 13.75 132 45174 31427 110512566
Neurotoxicity 187.24 13.75 148 45158 42059 110501934
Off label use 185.17 13.75 1145 44161 1499040 109044953
Cytomegalovirus chorioretinitis 184.51 13.75 79 45227 7049 110536944
Pancreatitis 180.80 13.75 207 45099 93326 110450667
Viral infection 175.16 13.75 157 45149 52982 110491011
Thymus hypoplasia 173.40 13.75 52 45254 1635 110542358
Clostridium difficile colitis 169.91 13.75 142 45164 43636 110500357
Bone marrow failure 167.55 13.75 159 45147 57689 110486304
Glioma 167.38 13.75 44 45262 844 110543149
Second primary malignancy 165.24 13.75 99 45207 17969 110526024
Pseudomonal sepsis 163.42 13.75 78 45228 8968 110535025
Mucosal inflammation 163.02 13.75 199 45107 95942 110448051
Enterobacter infection 162.37 13.75 68 45238 5743 110538250
Lymphoid tissue hypoplasia 161.15 13.75 49 45257 1616 110542377
Leukoencephalopathy 156.16 13.75 76 45230 9119 110534874
Pneumatosis intestinalis 155.47 13.75 74 45232 8455 110535538
Aspergillus infection 154.38 13.75 108 45198 25508 110518485
Enteritis 152.33 13.75 96 45210 19060 110524933
Hyperbilirubinaemia 150.08 13.75 114 45192 30557 110513436
Glioblastoma multiforme 144.85 13.75 44 45262 1446 110542547
Acute myeloid leukaemia 138.42 13.75 119 45187 37991 110506002
Myelodysplastic syndrome transformation 137.45 13.75 37 45269 780 110543213
Viraemia 131.62 13.75 53 45253 4049 110539944
Osteonecrosis 121.82 13.75 105 45201 33636 110510357
Fall 116.16 13.75 51 45255 603431 109940562
Joint swelling 109.15 13.75 24 45282 442821 110101172
Venoocclusive disease 106.38 13.75 52 45254 6298 110537695
Leukaemia recurrent 105.83 13.75 42 45264 3089 110540904
Myelodysplastic syndrome 104.68 13.75 101 45205 37383 110506610
Dyspnoea 101.61 13.75 187 45119 1106685 109437308
Histoplasmosis disseminated 100.21 13.75 43 45263 3856 110540137
Pancreatitis acute 97.69 13.75 122 45184 60152 110483841
Peripheral swelling 97.36 13.75 23 45283 404011 110139982
Neoplasm recurrence 97.21 13.75 46 45260 5186 110538807
Abdominal pain 96.61 13.75 441 44865 512548 110031445
Enterovirus infection 96.57 13.75 38 45268 2732 110541261
Sepsis 91.92 13.75 319 44987 327027 110216966
Pain 84.34 13.75 165 45141 954790 109589203
Enterovirus test positive 83.99 13.75 21 45285 327 110543666
Contraindicated product administered 81.75 13.75 5 45301 248262 110295731
Colitis 80.74 13.75 148 45158 102175 110441818
Swelling 80.67 13.75 22 45284 351019 110192974
Multiple-drug resistance 80.20 13.75 56 45250 13179 110530814
Abscess bacterial 79.80 13.75 25 45281 912 110543081
Fungal infection 79.41 13.75 101 45205 50705 110493288
Hypertransaminasaemia 78.60 13.75 71 45235 24184 110519809
Leukopenia 78.20 13.75 182 45124 148609 110395384
Venoocclusive liver disease 77.66 13.75 58 45248 15149 110528844
Epstein-Barr virus infection 77.32 13.75 63 45243 18675 110525318
Bronchopulmonary aspergillosis 76.93 13.75 77 45229 29786 110514207
Myelopathy 76.81 13.75 40 45266 5536 110538457
Temporal lobe epilepsy 76.52 13.75 21 45285 477 110543516
Alanine aminotransferase increased 75.82 13.75 205 45101 183568 110360425
Systemic lupus erythematosus 75.76 13.75 8 45298 254330 110289663
Colitis ulcerative 74.23 13.75 122 45184 77241 110466752
Cytogenetic abnormality 73.68 13.75 25 45281 1177 110542816
Synovitis 73.57 13.75 12 45294 274080 110269913
Human rhinovirus test positive 72.59 13.75 25 45281 1232 110542761
Cytomegalovirus viraemia 71.78 13.75 59 45247 17705 110526288
Glossodynia 71.53 13.75 5 45301 221999 110321994
Thrombocytopenia 70.93 13.75 307 44999 348578 110195415
Death 70.47 13.75 111 45195 698758 109845235
Nodular regenerative hyperplasia 69.87 13.75 26 45280 1605 110542388
Perineal necrosis 69.38 13.75 16 45290 173 110543820
Dizziness 69.36 13.75 112 45194 698081 109845912
Intracardiac thrombus 65.71 13.75 33 45273 4235 110539758
Epstein-Barr virus associated lymphoproliferative disorder 64.87 13.75 34 45272 4768 110539225
Confusional state 64.78 13.75 58 45248 468622 110075371
Lower respiratory tract infection 64.45 13.75 11 45295 243095 110300898
Crohn's disease 64.24 13.75 26 45280 2012 110541981
Drug clearance decreased 63.84 13.75 32 45274 4090 110539903
Coagulopathy 63.42 13.75 81 45225 40830 110503163
Hepatocellular injury 62.87 13.75 90 45216 50552 110493441
Intestinal stenosis 62.60 13.75 33 45273 4682 110539311
Intracranial pressure increased 62.50 13.75 44 45262 10491 110533502
Mucormycosis 62.15 13.75 44 45262 10584 110533409
Pneumonia fungal 61.71 13.75 50 45256 14704 110529289
Trichodysplasia spinulosa 61.09 13.75 21 45285 1029 110542964
Neutrophil count decreased 60.35 13.75 145 45161 120796 110423197
Pericarditis 60.14 13.75 9 45297 219105 110324888
Wound 59.16 13.75 12 45294 234425 110309568
Lentigo 58.75 13.75 19 45287 769 110543224
Venous thrombosis 58.70 13.75 39 45267 8466 110535527
Depression 57.61 13.75 29 45277 317306 110226687
Muscle spasms 57.53 13.75 21 45285 278136 110265857
Osteoarthritis 56.34 13.75 5 45301 182618 110361375
Discomfort 56.29 13.75 10 45296 214697 110329296
Picornavirus infection 56.25 13.75 13 45293 142 110543851
Pruritus 56.13 13.75 95 45211 581465 109962528
Diffuse alveolar damage 55.66 13.75 29 45277 4018 110539975
Atrial fibrillation 55.42 13.75 13 45293 229629 110314364
Abdominal discomfort 55.30 13.75 48 45258 393810 110150183
Pneumocystis jirovecii pneumonia 54.60 13.75 77 45229 42658 110501335
Inflammatory bowel disease 54.39 13.75 35 45271 7199 110536794
Insomnia 54.30 13.75 41 45265 360549 110183444
HCoV-HKU1 infection 54.17 13.75 11 45295 61 110543932
Arthropathy 54.14 13.75 25 45281 287497 110256496
Mobility decreased 52.46 13.75 16 45290 237406 110306587
Ileal stenosis 52.45 13.75 26 45280 3244 110540749
Coronavirus infection 52.33 13.75 38 45268 9507 110534486
Blood cholesterol increased 52.09 13.75 7 45299 184778 110359215
Fistula 51.97 13.75 46 45260 15253 110528740
Musculoskeletal stiffness 51.65 13.75 25 45281 279797 110264196
Asthma 51.59 13.75 19 45287 250272 110293721
Cytomegalovirus infection 51.07 13.75 85 45221 54359 110489634
Herpes simplex 50.79 13.75 46 45260 15718 110528275
Completed suicide 50.63 13.75 18 45288 242363 110301630
Cholestasis 50.48 13.75 93 45213 64425 110479568
Cytopenia 50.46 13.75 62 45244 30054 110513939
Molluscum contagiosum 50.24 13.75 16 45290 616 110543377
Oesophageal candidiasis 50.18 13.75 40 45266 11494 110532499
Gastroenteritis norovirus 50.02 13.75 26 45280 3585 110540408
Seizure 49.88 13.75 201 45105 220984 110323009
Cerebral venous sinus thrombosis 49.37 13.75 24 45282 2871 110541122
Diffuse large B-cell lymphoma 48.51 13.75 45 45261 15853 110528140
General physical health deterioration 48.31 13.75 62 45244 425233 110118760
Superior sagittal sinus thrombosis 48.00 13.75 18 45288 1135 110542858
Oral herpes 47.57 13.75 66 45240 36014 110507979
Drug specific antibody present 47.21 13.75 34 45272 8400 110535593
Fibrinous bronchitis 45.70 13.75 11 45295 145 110543848
Anaemia megaloblastic 45.61 13.75 16 45290 833 110543160
Bacillus infection 45.47 13.75 19 45287 1595 110542398
Fatigue 45.44 13.75 302 45004 1215656 109328337
Perineal infection 45.28 13.75 16 45290 851 110543142
Device related infection 44.38 13.75 67 45239 39452 110504541
Hypoalbuminaemia 44.33 13.75 57 45249 28917 110515076
Malaise 44.28 13.75 135 45171 671684 109872309
Blister 44.01 13.75 19 45287 227357 110316636
Neutropenic colitis 43.97 13.75 32 45274 8033 110535960
Impaired healing 43.92 13.75 13 45293 196704 110347289
Anal abscess 43.59 13.75 37 45269 11601 110532392
Diarrhoea haemorrhagic 43.39 13.75 42 45264 15597 110528396
Blood bilirubin increased 43.30 13.75 96 45210 75876 110468117
Histoplasmosis 43.03 13.75 22 45284 2931 110541062
Injury 42.84 13.75 10 45296 177255 110366738
Lip scab 42.72 13.75 10 45296 116 110543877
B-cell lymphoma 42.72 13.75 30 45276 7124 110536869
Bile acid malabsorption 41.85 13.75 13 45293 461 110543532
Ill-defined disorder 41.78 13.75 7 45299 156846 110387147
Angiolymphoid hyperplasia with eosinophilia 41.60 13.75 10 45296 131 110543862
C-reactive protein abnormal 41.54 13.75 3 45303 129692 110414301
Dry mouth 41.50 13.75 15 45291 199933 110344060
Bacterial vulvovaginitis 41.36 13.75 14 45292 654 110543339
Sleep disorder 41.06 13.75 15 45291 198629 110345364
Urticaria 41.06 13.75 42 45264 318815 110225178
Subacute combined cord degeneration 40.68 13.75 12 45294 356 110543637
Cellulitis 39.92 13.75 128 45178 125888 110418105
Intestinal resection 39.78 13.75 23 45283 3906 110540087
Wheezing 39.74 13.75 28 45278 255202 110288791
Drug hypersensitivity 39.50 13.75 79 45227 454011 110089982
Folliculitis 39.45 13.75 10 45296 167643 110376350
Rash 39.22 13.75 188 45118 820776 109723217
Epstein-Barr virus associated lymphoma 38.30 13.75 17 45289 1653 110542340
Oedema peripheral 38.26 13.75 47 45259 328613 110215380
Lymphopenia 38.05 13.75 63 45243 40107 110503886
Portal hypertension 37.67 13.75 30 45276 8607 110535386
Proctalgia 37.61 13.75 36 45270 13186 110530807
Haemolytic uraemic syndrome 37.18 13.75 24 45282 4961 110539032
Cardiotoxicity 37.13 13.75 40 45266 16841 110527152
Feeding intolerance 36.96 13.75 15 45291 1169 110542824
Encephalitis 36.88 13.75 42 45264 18797 110525196
Escherichia infection 36.66 13.75 47 45259 23769 110520224
Cell-mediated immune deficiency 36.45 13.75 10 45296 227 110543766
Atypical haemolytic uraemic syndrome 36.37 13.75 16 45290 1524 110542469
Hepatic enzyme increased 36.20 13.75 47 45259 320845 110223148
Angiocentric lymphoma 36.09 13.75 15 45291 1242 110542751
Anal fistula 36.04 13.75 29 45277 8444 110535549
Nasopharyngitis 35.69 13.75 67 45239 394294 110149699
Migraine 35.41 13.75 13 45293 171639 110372354
Product dose omission issue 35.41 13.75 48 45258 321734 110222259
Platelet count decreased 35.32 13.75 187 45119 230256 110313737
Posterior reversible encephalopathy syndrome 34.65 13.75 55 45251 33806 110510187
Segmental diverticular colitis 34.62 13.75 9 45297 165 110543828
Blood culture positive 34.57 13.75 29 45277 8947 110535046
Haematopoietic neoplasm 34.56 13.75 8 45298 88 110543905
Cytomegalovirus colitis 33.99 13.75 26 45280 7035 110536958
Asthenia 33.94 13.75 156 45150 688843 109855150
Epstein Barr virus positive mucocutaneous ulcer 33.76 13.75 14 45292 1153 110542840
Cardiac failure congestive 33.67 13.75 10 45296 150990 110393003
Perirectal abscess 33.59 13.75 17 45289 2217 110541776
Blood fibrinogen decreased 33.48 13.75 18 45288 2657 110541336
Acute lymphocytic leukaemia refractory 33.03 13.75 9 45297 199 110543794
Road traffic accident 32.96 13.75 3 45303 107395 110436598
Irritable bowel syndrome 32.94 13.75 13 45293 164202 110379791
Memory impairment 32.83 13.75 20 45286 196924 110347069
Drug metabolite level high 32.82 13.75 7 45299 51 110543942
Musculoskeletal pain 32.79 13.75 17 45289 183006 110360987
Otitis media acute 32.78 13.75 15 45291 1567 110542426
Candida endophthalmitis 32.77 13.75 9 45297 205 110543788
Splenomegaly 32.57 13.75 45 45261 24453 110519540
Systemic mycosis 32.48 13.75 20 45286 3809 110540184
Septic shock 32.25 13.75 139 45167 157389 110386604
Rectal cancer metastatic 31.98 13.75 11 45295 540 110543453
Disseminated aspergillosis 31.91 13.75 17 45289 2463 110541530
Drug intolerance 31.80 13.75 75 45231 406437 110137556
Transaminases increased 31.61 13.75 76 45230 63314 110480679
Hypoglycaemia 31.53 13.75 112 45194 115992 110428001
Pedal pulse abnormal 31.46 13.75 9 45297 239 110543754
Polyneuropathy 31.39 13.75 51 45255 31961 110512032
Ileocaecal resection 31.22 13.75 11 45295 580 110543413
Acute monocytic leukaemia 30.81 13.75 11 45295 603 110543390
Cardiac ventricular thrombosis 30.75 13.75 18 45288 3129 110540864
Neuropathy peripheral 30.62 13.75 150 45156 179127 110364866
Lipase increased 30.57 13.75 38 45268 18634 110525359
Overgrowth fungal 30.45 13.75 8 45298 153 110543840
Hyperkalaemia 30.26 13.75 9 45297 135787 110408206
Fusarium infection 30.15 13.75 17 45289 2754 110541239
Somnolence 30.14 13.75 47 45259 297402 110246591
Cytomegalovirus hepatitis 30.09 13.75 12 45294 894 110543099
Anxiety 30.02 13.75 60 45246 345018 110198975
Strongyloidiasis 29.98 13.75 21 45285 4965 110539028
Chest pain 29.79 13.75 69 45237 376306 110167687
Dyspepsia 29.65 13.75 21 45285 190944 110353049
Alopecia 29.57 13.75 66 45240 364687 110179306
Aplasia 29.43 13.75 25 45281 7848 110536145
Infusion related reaction 29.28 13.75 71 45235 381091 110162902
Xanthogranuloma 29.24 13.75 7 45299 90 110543903
Steatohepatitis 29.21 13.75 13 45293 1272 110542721
Drug level decreased 29.18 13.75 37 45269 18511 110525482
Contusion 28.63 13.75 32 45274 233329 110310664
Juvenile chronic myelomonocytic leukaemia 28.60 13.75 6 45300 40 110543953
Functional gastrointestinal disorder 28.52 13.75 22 45284 6027 110537966
Abdominal adhesions 28.40 13.75 19 45287 4171 110539822
Neurological examination abnormal 28.33 13.75 11 45295 763 110543230
Hypophagia 28.31 13.75 65 45241 52561 110491432
Type 2 diabetes mellitus 28.17 13.75 19 45287 177213 110366780
Anaemia 28.10 13.75 345 44961 546741 109997252
Rectal abscess 27.88 13.75 16 45290 2680 110541313
Coma 27.79 13.75 7 45299 117862 110426131
Clostridium difficile infection 27.62 13.75 64 45242 52065 110491928
Cerebral haemangioma 27.42 13.75 7 45299 119 110543874
Intentional overdose 27.39 13.75 10 45296 132491 110411502
Staphylococcal bacteraemia 27.38 13.75 34 45272 16654 110527339
Abscess intestinal 27.37 13.75 17 45289 3287 110540706
Chloroma 27.36 13.75 11 45295 837 110543156
Pseudomonas test positive 27.13 13.75 15 45291 2339 110541654
Device related bacteraemia 26.55 13.75 12 45294 1218 110542775
Mixed anxiety and depressive disorder 26.51 13.75 10 45296 641 110543352
Central obesity 26.32 13.75 14 45292 2022 110541971
Cushingoid 26.20 13.75 28 45278 11684 110532309
Staphylococcal sepsis 26.17 13.75 34 45272 17420 110526573
Gastrointestinal wall thickening 25.94 13.75 17 45289 3606 110540387
Hepatosplenomegaly 25.92 13.75 22 45284 6897 110537096
Abscess limb 25.82 13.75 24 45282 8473 110535520
Joint range of motion decreased 25.51 13.75 9 45297 121823 110422170
Melanocytic naevus 25.44 13.75 20 45286 5634 110538359
Pseudomonal bacteraemia 25.33 13.75 18 45288 4353 110539640
Disease recurrence 25.23 13.75 68 45238 60716 110483277
Angioedema 24.93 13.75 5 45301 98495 110445498
Fistula of small intestine 24.84 13.75 11 45295 1064 110542929
Chronic obstructive pulmonary disease 24.75 13.75 7 45299 109151 110434842
Small intestinal obstruction 24.65 13.75 46 45260 32167 110511826
Pulmonary haemorrhage 24.59 13.75 32 45274 16424 110527569
Anal fissure 24.57 13.75 25 45281 9856 110534137
Respiratory syncytial virus infection 24.56 13.75 30 45276 14454 110529539
Multiple organ dysfunction syndrome 24.54 13.75 125 45181 151585 110392408
Linitis plastica 24.43 13.75 4 45302 4 110543989
Hyponatraemia 24.41 13.75 32 45274 217621 110326372
Antithrombin III 24.39 13.75 6 45300 87 110543906
Pleuroparenchymal fibroelastosis 24.03 13.75 8 45298 355 110543638
Gastrooesophageal reflux disease 23.97 13.75 23 45283 179953 110364040
Magnetic resonance imaging head abnormal 23.89 13.75 16 45290 3519 110540474
Scedosporium infection 23.86 13.75 14 45292 2444 110541549
Anorectal cellulitis 23.79 13.75 6 45300 97 110543896
Vocal cord paralysis 23.73 13.75 15 45291 2991 110541002
T-cell lymphoma 23.72 13.75 12 45294 1564 110542429
Anal inflammation 23.66 13.75 14 45292 2482 110541511
Gastrointestinal inflammation 23.62 13.75 24 45282 9445 110534548
Hippocampal sclerosis 23.59 13.75 7 45299 212 110543781
Oedema 23.42 13.75 31 45275 209945 110334048
Chest discomfort 23.40 13.75 22 45284 173826 110370167
Cheilitis 23.36 13.75 20 45286 6345 110537648
Prescribed overdose 23.12 13.75 4 45302 87577 110456416
Anorectal infection 23.07 13.75 9 45297 632 110543361
Autoimmune lymphoproliferative syndrome 23.04 13.75 7 45299 230 110543763
Large intestinal ulcer 22.99 13.75 19 45287 5742 110538251
Pneumonia toxoplasmal 22.92 13.75 5 45301 41 110543952
Pulmonary mucormycosis 22.92 13.75 13 45293 2130 110541863
Large intestinal stenosis 22.92 13.75 16 45290 3764 110540229
Adverse event 22.85 13.75 8 45298 108801 110435192
Influenza B virus test positive 22.81 13.75 8 45298 416 110543577
Toe walking 22.81 13.75 4 45302 8 110543985
Calcium ionised decreased 22.74 13.75 9 45297 657 110543336
Skin toxicity 22.61 13.75 26 45280 11757 110532236
Clostridium test positive 22.55 13.75 25 45281 10868 110533125
Rectal stenosis 22.54 13.75 8 45298 431 110543562
Meningitis coccidioides 22.51 13.75 5 45301 45 110543948
Vomiting 22.41 13.75 509 44797 910166 109633827
Astrocytoma 22.41 13.75 7 45299 253 110543740
Ocular icterus 22.17 13.75 19 45287 6034 110537959
Acral lentiginous melanoma 22.13 13.75 5 45301 49 110543944
Jugular vein thrombosis 22.11 13.75 18 45288 5327 110538666
Hallucination 22.10 13.75 7 45299 101425 110442568
Aborted pregnancy 22.03 13.75 5 45301 50 110543943
Feeling abnormal 21.92 13.75 25 45281 180686 110363307
Haemophilus test positive 21.92 13.75 6 45300 135 110543858
Peripheral motor neuropathy 21.80 13.75 16 45290 4070 110539923
Lung disorder 21.74 13.75 25 45281 180022 110363971
Herpes zoster meningoencephalitis 21.64 13.75 10 45296 1068 110542925
Facial paralysis 21.63 13.75 37 45269 24177 110519816
Product quality issue 21.61 13.75 3 45303 77296 110466697
Anamnestic reaction 21.36 13.75 5 45301 58 110543935
Hyperglycaemia 21.34 13.75 80 45226 85010 110458983
Metapneumovirus infection 21.33 13.75 13 45293 2431 110541562
Antithrombin III decreased 21.22 13.75 8 45298 512 110543481
Enterocolitis 21.09 13.75 32 45274 18917 110525076
Respiratory distress 20.94 13.75 69 45237 68805 110475188
Malnutrition 20.93 13.75 39 45267 27240 110516753
Sinusitis 20.68 13.75 58 45248 296630 110247363
Thymus enlargement 20.67 13.75 6 45300 168 110543825
Arthralgia 20.64 13.75 212 45094 779420 109764573
Pulmonary fibrosis 20.59 13.75 8 45298 102034 110441959
Hepatitis E 20.55 13.75 16 45290 4443 110539550
Urinary tract infection 20.44 13.75 67 45239 326215 110217778
Grip strength decreased 20.43 13.75 4 45302 80170 110463823
Wound infection 20.42 13.75 7 45299 96458 110447535
Dystrophic calcification 20.37 13.75 6 45300 177 110543816
Pseudomonas infection 20.35 13.75 39 45267 27814 110516179
Bacteraemia 20.25 13.75 50 45256 42340 110501653
Gastroenteritis rotavirus 20.01 13.75 8 45298 600 110543393
Maternal exposure during pregnancy 19.94 13.75 47 45259 254836 110289157
Tonsil cancer 19.82 13.75 10 45296 1296 110542697
Bilirubin conjugated increased 19.73 13.75 18 45288 6206 110537787
Minimal residual disease 19.63 13.75 9 45297 944 110543049
Pancreatitis necrotising 19.61 13.75 17 45289 5484 110538509
Staphylococcal infection 19.44 13.75 68 45238 69876 110474117
Adrenocortical carcinoma 19.16 13.75 5 45301 93 110543900
Wrong technique in product usage process 19.08 13.75 6 45300 87342 110456651
Human anaplasmosis 19.06 13.75 5 45301 95 110543898
Bifidobacterium infection 18.64 13.75 5 45301 104 110543889
Demodicidosis 18.62 13.75 6 45300 240 110543753
Jaundice 18.59 13.75 60 45246 59176 110484817
Enterobacter bacteraemia 18.57 13.75 10 45296 1480 110542513
Respiratory syncytial virus test positive 18.55 13.75 10 45296 1484 110542509
Metastases to rectum 18.54 13.75 4 45302 31 110543962
Hypersensitivity 18.39 13.75 94 45212 403904 110140089
Human metapneumovirus test positive 18.36 13.75 6 45300 251 110543742
Porphyria non-acute 18.31 13.75 8 45298 749 110543244
Hemiparesis 18.11 13.75 49 45257 43854 110500139
Transverse sinus thrombosis 18.10 13.75 8 45298 770 110543223
Hospitalisation 18.07 13.75 19 45287 142474 110401519
Hip deformity 17.94 13.75 6 45300 270 110543723
Hepatic fibrosis 17.54 13.75 19 45287 8047 110535946
Lymphoproliferative disorder 17.47 13.75 18 45288 7200 110536793
Encopresis 17.43 13.75 5 45301 134 110543859
Terminal ileitis 17.43 13.75 10 45296 1674 110542319
Acute motor-sensory axonal neuropathy 17.43 13.75 7 45299 531 110543462
Lower respiratory tract infection fungal 17.36 13.75 8 45298 849 110543144
Haemophilus infection 17.32 13.75 12 45294 2788 110541205
Autoimmune disorder 17.26 13.75 3 45303 65480 110478513
Pneumonia viral 17.14 13.75 22 45284 11135 110532858
Eosinophilic pneumonia chronic 17.07 13.75 7 45299 560 110543433
Bone marrow disorder 17.00 13.75 14 45292 4209 110539784
Viral pharyngitis 17.00 13.75 7 45299 566 110543427
Acute lymphocytic leukaemia 16.98 13.75 16 45290 5749 110538244
Otitis media 16.94 13.75 18 45288 7458 110536535
Hypercholesterolaemia 16.93 13.75 8 45298 90829 110453164
Cell death 16.91 13.75 16 45290 5775 110538218
Therapeutic product effect decreased 16.85 13.75 48 45258 244268 110299725
Overdose 16.82 13.75 45 45261 233749 110310244
Haematocolpos 16.81 13.75 4 45302 50 110543943
Stenotrophomonas infection 16.76 13.75 16 45290 5842 110538151
Live birth 16.62 13.75 4 45302 69480 110474513
Suicide attempt 16.54 13.75 11 45295 103383 110440610
Chills 16.49 13.75 134 45172 190446 110353547
Differentiation syndrome 16.42 13.75 12 45294 3032 110540961
Epidermal necrosis 16.40 13.75 12 45294 3038 110540955
Gastrointestinal sounds abnormal 16.39 13.75 16 45290 6002 110537991
Disseminated cytomegaloviral infection 16.38 13.75 7 45299 621 110543372
Drug level below therapeutic 16.36 13.75 22 45284 11651 110532342
Injection site reaction 16.36 13.75 8 45298 89062 110454931
Blood growth hormone decreased 16.08 13.75 4 45302 61 110543932
Blood pressure fluctuation 16.06 13.75 67 45239 74757 110469236
Pseudopolyp 16.05 13.75 7 45299 653 110543340
Vascular access complication 16.03 13.75 11 45295 2517 110541476
Cardiac iron overload 16.01 13.75 4 45302 62 110543931
Visual impairment 15.87 13.75 19 45287 134409 110409584
Cutaneous leishmaniasis 15.84 13.75 6 45300 389 110543604
Amnesia 15.83 13.75 12 45294 105396 110438597
Hepatic steatosis 15.82 13.75 50 45256 48781 110495212
Enterocolitis haemorrhagic 15.73 13.75 11 45295 2593 110541400
Rhinocerebral mucormycosis 15.68 13.75 9 45297 1508 110542485
Placental transfusion syndrome 15.61 13.75 4 45302 69 110543924
White blood cell count decreased 15.59 13.75 153 45153 229237 110314756
Respirovirus test 15.58 13.75 3 45303 12 110543981
Meningitis enterococcal 15.54 13.75 5 45301 199 110543794
Perineal pain 15.53 13.75 9 45297 1536 110542457
Cytomegalovirus gastrointestinal infection 15.43 13.75 7 45299 717 110543276
Frequent bowel movements 15.38 13.75 64 45242 71326 110472667
Cardiac disorder 15.36 13.75 6 45300 76274 110467719
Myocardial infarction 15.36 13.75 35 45271 192048 110351945
Gait inability 15.34 13.75 20 45286 136356 110407637
Syncope 15.32 13.75 38 45268 202498 110341495
Partial seizures 15.32 13.75 21 45285 11328 110532665
Oesophageal mass 15.30 13.75 4 45302 75 110543918
Metastases to pancreas 15.23 13.75 7 45299 738 110543255
Dry skin 15.23 13.75 13 45293 107640 110436353
Coagulation factor VII level decreased 15.15 13.75 5 45301 216 110543777
Klebsiella sepsis 15.14 13.75 13 45293 4140 110539853
Enterocolitis infectious 15.10 13.75 12 45294 3432 110540561
Dysplastic naevus syndrome 15.03 13.75 3 45303 15 110543978
Abscess fungal 15.00 13.75 6 45300 450 110543543
Drug level above therapeutic 14.98 13.75 21 45285 11567 110532426
Listeriosis 14.97 13.75 11 45295 2803 110541190
Disseminated trichosporonosis 14.93 13.75 5 45301 226 110543767
Faecal calprotectin increased 14.92 13.75 16 45290 6703 110537290
Arrhythmia 14.81 13.75 5 45301 69570 110474423
Stomatitis necrotising 14.81 13.75 5 45301 232 110543761
Mucoepidermoid carcinoma 14.74 13.75 4 45302 87 110543906
Haemophilus bacteraemia 14.72 13.75 5 45301 236 110543757
Acute myocardial infarction 14.68 13.75 8 45298 83769 110460224
Escherichia test positive 14.68 13.75 12 45294 3572 110540421
Mucous stools 14.67 13.75 16 45290 6831 110537162
Neutrophil count abnormal 14.65 13.75 14 45292 5118 110538875
Klebsiella infection 14.60 13.75 28 45278 19981 110524012
Therapeutic response unexpected 14.57 13.75 31 45275 23812 110520181
Red blood cell microcytes present 14.57 13.75 3 45303 18 110543975
Listeria sepsis 14.55 13.75 7 45299 819 110543174
Red blood cell sedimentation rate increased 14.43 13.75 7 45299 78295 110465698
Multiple lentigines syndrome 14.43 13.75 5 45301 251 110543742
Oral disorder 14.41 13.75 21 45285 11982 110532011
Mucocutaneous candidiasis 14.37 13.75 4 45302 96 110543897
Cardiac failure 14.35 13.75 35 45271 187591 110356402
Eye opacity 14.30 13.75 3 45303 20 110543973
Rhabdomyolysis 14.23 13.75 17 45289 120384 110423609
Drug-induced liver injury 14.19 13.75 91 45215 119976 110424017
Paraplegia 14.18 13.75 15 45291 6185 110537808
West Nile viral infection 14.06 13.75 8 45298 1318 110542675
Gamma-glutamyltransferase increased 14.03 13.75 56 45250 61253 110482740
Delirium 13.99 13.75 21 45285 135004 110408989
Protein-losing gastroenteropathy 13.93 13.75 7 45299 899 110543094
Haematochezia 13.93 13.75 88 45218 115436 110428557
Petechiae 13.89 13.75 30 45276 23287 110520706
Pneumonia aspiration 13.88 13.75 8 45298 81225 110462768
Gastrointestinal protozoal infection 13.85 13.75 4 45302 110 110543883
Malignant neoplasm progression 13.80 13.75 32 45274 174535 110369458
Hypertension 13.77 13.75 138 45168 509946 110034047

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Purine analogues
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:149553 anticoronaviral agent

Related Drugs by ATC class:

L01BB Purine analogues 5 drugs
cladribineclofarabinefludarabine phosphatenelarabinethioguanine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute promyelocytic leukemia, FAB M3 indication 110004001
Psoriasis with arthropathy off-label use 33339001
Crohn's disease off-label use 34000006
Ulcerative colitis off-label use 64766004 DOID:8577
Acute myeloid leukemia, disease off-label use 91861009
Polycythemia vera off-label use 109992005
Hyperbilirubinemia contraindication 14783006 DOID:2741
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Gastrointestinal ulcer contraindication 40845000
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Ascites contraindication 389026000
Breastfeeding (mother) contraindication 413712001
Hepatosplenic T-cell lymphoma contraindication 445406001
Chemotherapy-Induced Hyperuricemia contraindication
Thiopurine S-Methyltransferase Deficiency contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.99 acidic
pKa2 10.76 acidic
pKa3 3.37 Basic
pKa4 1.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Amidophosphoribosyltransferase Enzyme INHIBITOR DRUGBANK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.79 DRUG MATRIX
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Thiopurine S-methyltransferase Enzyme WOMBAT-PK
Purine nucleoside phosphorylase Enzyme WOMBAT-PK
Purine nucleoside phosphorylase Enzyme Kd 4.10 CHEMBL

External reference:

IDSource
4018776 VUID
N0000147079 NUI
D00161 KEGG_DRUG
4018776 VANDF
C0000618 UMLSCUI
CHEBI:50667 CHEBI
PM6 PDB_CHEM_ID
CHEMBL1200751 ChEMBL_ID
DB01033 DRUGBANK_ID
D015122 MESH_DESCRIPTOR_UI
667490 PUBCHEM_CID
7226 IUPHAR_LIGAND_ID
E7WED276I5 UNII
103 RXNORM
3886 MMSL
48948 MMSL
5052 MMSL
NOCODE MMSL
d00289 MMSL
002647 NDDF
1039008 SNOMEDCT_US
386835005 SNOMEDCT_US
6112-76-1 SECONDARY_CAS_RN
E7WED276I5 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MERCAPTOPURINE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0879 SUSPENSION 20 mg ORAL ANDA 30 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 0054-4581 TABLET 50 mg ORAL ANDA 31 sections
MERCAPTOPURINE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4582 SUSPENSION 20 mg ORAL ANDA 30 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 51407-983 TABLET 50 mg ORAL ANDA 31 sections
mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5282 TABLET 50 mg ORAL ANDA 24 sections
PURIXAN HUMAN PRESCRIPTION DRUG LABEL 1 62484-0020 SUSPENSION 20 mg ORAL NDA 19 sections
MERCAPTOPURINE HUMAN PRESCRIPTION DRUG LABEL 1 62484-1020 SUSPENSION 20 mg ORAL NDA authorized generic 19 sections
Mercaptopurine HUMAN PRESCRIPTION DRUG LABEL 1 69076-913 TABLET 50 mg ORAL NDA authorized generic 31 sections
Mercaptopurine Human Prescription Drug Label 1 71921-150 TABLET 50 mg ORAL NDA 27 sections