mephentermine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 1694 100-92-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mephentermine
  • mephine
  • N-Methylphentermine
  • vialin
  • mephentermine sulfate
  • mephentermine hemisulfate
  • mephentermine sulphate
A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
  • Molecular weight: 163.26
  • Formula: C11H17N
  • CLOGP: 2.29
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -2.55
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1951 FDA BAXTER HLTHCARE CORP

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA11 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058646 Adrenergic alpha-1 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Low blood pressure indication 45007003
Prevention of Hypotension During Spinal Anesthesia indication
Hypotension Secondary to Spinal Anesthesia indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1A adrenergic receptor GPCR AGONIST DRUGBANK CHEMBL

External reference:

IDSource
4019814 VUID
N0000147903 NUI
D08180 KEGG_DRUG
1212-72-2 SECONDARY_CAS_RN
4018029 VANDF
4019814 VANDF
C0025380 UMLSCUI
CHEBI:6755 CHEBI
CHEMBL1201234 ChEMBL_ID
CHEMBL3184799 ChEMBL_ID
CHEMBL1200996 ChEMBL_ID
D008616 MESH_DESCRIPTOR_UI
DB01365 DRUGBANK_ID
7222 IUPHAR_LIGAND_ID
495 INN_ID
TEZ91L71V4 UNII
3677 PUBCHEM_CID
6756 RXNORM
5047 MMSL
d00701 MMSL
001830 NDDF
004736 NDDF
31799007 SNOMEDCT_US
38648002 SNOMEDCT_US

Pharmaceutical products:

None