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| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihyperlipidaemic substances, HMG CoA reductase inhibitors | 1612 | 75330-75-5 |
| Dose | Unit | Route |
|---|---|---|
| 45 | mg | O |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.29 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 5 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 | 22 | |||
| kinase-selectivity-class | AXL,GRK2 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.513 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | High | 1 | |
| rat-kpuu-brain | Rat brain Kpuu | 0.805 | % | High | 1 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 31, 1987 | FDA | MERCK |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myalgia | 73.11 | 12.67 | 136 | 20047 | 174989 | 90433275 |
| Cardiac failure congestive | 72.12 | 12.67 | 99 | 20084 | 98595 | 90509669 |
| Contraindicated product administered | 55.89 | 12.67 | 4 | 20179 | 320135 | 90288129 |
| Synovitis | 55.12 | 12.67 | 5 | 20178 | 329747 | 90278517 |
| Infusion related reaction | 54.42 | 12.67 | 13 | 20170 | 416767 | 90191497 |
| Systemic lupus erythematosus | 54.25 | 12.67 | 8 | 20175 | 361888 | 90246376 |
| Blood glucose increased | 52.92 | 12.67 | 84 | 20099 | 95162 | 90513102 |
| Atrial fibrillation | 49.88 | 12.67 | 99 | 20084 | 133512 | 90474752 |
| Glossodynia | 48.48 | 12.67 | 7 | 20176 | 321772 | 90286492 |
| Rhabdomyolysis | 47.75 | 12.67 | 58 | 20125 | 51198 | 90557066 |
| Dehydration | 41.74 | 12.67 | 116 | 20067 | 194331 | 90413933 |
| General physical health deterioration | 39.25 | 12.67 | 15 | 20168 | 355100 | 90253164 |
| Lower respiratory tract infection | 38.82 | 12.67 | 5 | 20178 | 250654 | 90357610 |
| Exposure during pregnancy | 38.81 | 12.67 | 4 | 20179 | 238406 | 90369858 |
| Wound | 38.46 | 12.67 | 10 | 20173 | 302970 | 90305294 |
| Myocardial infarction | 37.73 | 12.67 | 77 | 20106 | 105895 | 90502369 |
| Hepatic enzyme increased | 35.51 | 12.67 | 18 | 20165 | 360718 | 90247546 |
| Treatment failure | 35.00 | 12.67 | 12 | 20171 | 303916 | 90304348 |
| Irritable bowel syndrome | 32.46 | 12.67 | 4 | 20179 | 207444 | 90400820 |
| Drug hypersensitivity | 31.82 | 12.67 | 194 | 19989 | 463415 | 90144849 |
| Feeling abnormal | 30.35 | 12.67 | 94 | 20089 | 167141 | 90441123 |
| Cerebrovascular accident | 29.82 | 12.67 | 77 | 20106 | 123456 | 90484808 |
| C-reactive protein increased | 29.63 | 12.67 | 3 | 20180 | 181386 | 90426878 |
| Coronary artery disease | 29.62 | 12.67 | 37 | 20146 | 33586 | 90574678 |
| Asthenia | 28.02 | 12.67 | 209 | 19974 | 533542 | 90074722 |
| Chronic obstructive pulmonary disease | 27.89 | 12.67 | 55 | 20128 | 73774 | 90534490 |
| Off label use | 27.14 | 12.67 | 140 | 20043 | 1102112 | 89506152 |
| Fall | 26.61 | 12.67 | 191 | 19992 | 481619 | 90126645 |
| Product dose omission issue | 25.96 | 12.67 | 131 | 20052 | 291556 | 90316708 |
| Alopecia | 25.94 | 12.67 | 44 | 20139 | 495027 | 90113237 |
| Death | 24.64 | 12.67 | 180 | 20003 | 456371 | 90151893 |
| Rheumatoid arthritis | 24.25 | 12.67 | 27 | 20156 | 362587 | 90245677 |
| Arthropathy | 23.70 | 12.67 | 28 | 20155 | 366214 | 90242050 |
| Product use issue | 22.68 | 12.67 | 24 | 20159 | 329895 | 90278369 |
| Drug intolerance | 22.34 | 12.67 | 41 | 20142 | 447550 | 90160714 |
| Retroperitoneal oedema | 21.86 | 12.67 | 4 | 20179 | 24 | 90608240 |
| Nausea | 21.31 | 12.67 | 356 | 19827 | 1109960 | 89498304 |
| Discomfort | 21.14 | 12.67 | 18 | 20165 | 274317 | 90333947 |
| Impaired healing | 21.13 | 12.67 | 13 | 20170 | 234186 | 90374078 |
| Liver injury | 20.94 | 12.67 | 6 | 20177 | 170561 | 90437703 |
| Myopathy | 20.89 | 12.67 | 20 | 20163 | 13498 | 90594766 |
| Muscle spasms | 20.25 | 12.67 | 110 | 20073 | 251773 | 90356491 |
| Pyrexia | 19.73 | 12.67 | 78 | 20105 | 660407 | 89947857 |
| Chronic kidney disease | 19.70 | 12.67 | 38 | 20145 | 50153 | 90558111 |
| Abdominal discomfort | 19.44 | 12.67 | 49 | 20134 | 477279 | 90130985 |
| Type 2 diabetes mellitus | 18.73 | 12.67 | 11 | 20172 | 203233 | 90405031 |
| Febrile neutropenia | 18.66 | 12.67 | 6 | 20177 | 158343 | 90449921 |
| Amyotrophic lateral sclerosis | 18.56 | 12.67 | 8 | 20175 | 1340 | 90606924 |
| Urinary tract infection | 18.52 | 12.67 | 124 | 20059 | 305508 | 90302756 |
| Fatigue | 18.26 | 12.67 | 359 | 19824 | 1153664 | 89454600 |
| Back pain | 17.64 | 12.67 | 126 | 20057 | 317049 | 90291215 |
| Therapeutic product effect decreased | 17.13 | 12.67 | 22 | 20161 | 277549 | 90330715 |
| Cardiomegaly | 16.95 | 12.67 | 21 | 20162 | 18904 | 90589360 |
| Dizziness | 16.92 | 12.67 | 203 | 19980 | 589081 | 90019183 |
| Joint swelling | 16.62 | 12.67 | 57 | 20126 | 503243 | 90105021 |
| Gastrointestinal haemorrhage | 16.61 | 12.67 | 51 | 20132 | 90197 | 90518067 |
| Visual acuity reduced | 16.36 | 12.67 | 23 | 20160 | 23387 | 90584877 |
| Joint range of motion decreased | 16.23 | 12.67 | 5 | 20178 | 135638 | 90472626 |
| Hypersensitivity | 16.04 | 12.67 | 50 | 20133 | 454627 | 90153637 |
| Ill-defined disorder | 15.68 | 12.67 | 11 | 20172 | 184880 | 90423384 |
| Hypoglycaemia | 15.29 | 12.67 | 42 | 20141 | 69806 | 90538458 |
| Pulmonary arterial pressure increased | 15.27 | 12.67 | 10 | 20173 | 3906 | 90604358 |
| Psoriatic arthropathy | 15.25 | 12.67 | 17 | 20166 | 228318 | 90379946 |
| Swelling | 14.84 | 12.67 | 46 | 20137 | 419012 | 90189252 |
| Renal failure | 14.70 | 12.67 | 63 | 20120 | 130944 | 90477320 |
| Oedema peripheral | 14.64 | 12.67 | 103 | 20080 | 257812 | 90350452 |
| Urinary incontinence | 14.20 | 12.67 | 28 | 20155 | 37538 | 90570726 |
| Mental status changes | 14.19 | 12.67 | 31 | 20152 | 44648 | 90563616 |
| Fibromyalgia | 14.17 | 12.67 | 15 | 20168 | 206254 | 90402010 |
| Withdrawal syndrome | 14.09 | 12.67 | 21 | 20162 | 22503 | 90585761 |
| Injury | 13.96 | 12.67 | 14 | 20169 | 197335 | 90410929 |
| Hypoxic-ischaemic encephalopathy | 13.68 | 12.67 | 10 | 20173 | 4658 | 90603606 |
| Nervousness | 13.63 | 12.67 | 26 | 20157 | 34030 | 90574234 |
| Gait disturbance | 13.62 | 12.67 | 102 | 20081 | 260394 | 90347870 |
| Inflammation | 13.41 | 12.67 | 12 | 20171 | 178580 | 90429684 |
| Gallbladder oedema | 13.20 | 12.67 | 4 | 20179 | 243 | 90608021 |
| Blood urea increased | 13.14 | 12.67 | 24 | 20159 | 30389 | 90577875 |
| Hip fracture | 12.92 | 12.67 | 25 | 20158 | 33052 | 90575212 |
| Blood potassium decreased | 12.82 | 12.67 | 31 | 20152 | 47696 | 90560568 |
| Blood cholesterol abnormal | 12.81 | 12.67 | 8 | 20175 | 2882 | 90605382 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myasthenic syndrome | 48.91 | 13.82 | 16 | 14616 | 805 | 42605898 |
| Rhabdomyolysis | 44.79 | 13.82 | 89 | 14543 | 77930 | 42528773 |
| Cardiac failure congestive | 41.37 | 13.82 | 91 | 14541 | 85511 | 42521192 |
| Off label use | 38.85 | 13.82 | 103 | 14529 | 638232 | 41968471 |
| Myalgia | 38.61 | 13.82 | 95 | 14537 | 95985 | 42510718 |
| Neck mass | 29.94 | 13.82 | 14 | 14618 | 1836 | 42604867 |
| Cerebrovascular accident | 29.86 | 13.82 | 87 | 14545 | 97073 | 42509630 |
| Febrile neutropenia | 28.61 | 13.82 | 14 | 14618 | 185689 | 42421014 |
| Myocardial infarction | 25.55 | 13.82 | 97 | 14535 | 123912 | 42482791 |
| Asthenia | 24.77 | 13.82 | 173 | 14459 | 280620 | 42326083 |
| Blood creatine phosphokinase increased | 24.03 | 13.82 | 52 | 14580 | 48286 | 42558417 |
| Back disorder | 23.55 | 13.82 | 20 | 14612 | 7494 | 42599209 |
| Diverticulum | 23.49 | 13.82 | 20 | 14612 | 7521 | 42599182 |
| Drug abuse | 23.22 | 13.82 | 4 | 14628 | 104767 | 42501936 |
| Injury | 22.88 | 13.82 | 33 | 14599 | 22283 | 42584420 |
| Myopathy | 21.39 | 13.82 | 25 | 14607 | 13736 | 42592967 |
| International normalised ratio increased | 20.80 | 13.82 | 49 | 14583 | 48119 | 42558584 |
| Sleep inertia | 19.24 | 13.82 | 4 | 14628 | 31 | 42606672 |
| Thrombocytosis | 17.67 | 13.82 | 14 | 14618 | 4761 | 42601942 |
| Blood glucose increased | 17.15 | 13.82 | 60 | 14572 | 73639 | 42533064 |
| Cardiovascular disorder | 17.09 | 13.82 | 22 | 14610 | 13343 | 42593360 |
| Anxiety | 16.91 | 13.82 | 83 | 14549 | 118477 | 42488226 |
| Completed suicide | 16.31 | 13.82 | 71 | 14561 | 96394 | 42510309 |
| Product use in unapproved indication | 16.09 | 13.82 | 24 | 14608 | 184432 | 42422271 |
| Hand deformity | 16.03 | 13.82 | 12 | 14620 | 3756 | 42602947 |
| Potentiating drug interaction | 15.88 | 13.82 | 15 | 14617 | 6453 | 42600250 |
| Vision blurred | 14.52 | 13.82 | 46 | 14586 | 53653 | 42553050 |
| Right ventricular failure | 14.26 | 13.82 | 17 | 14615 | 9538 | 42597165 |
| Pyrexia | 13.89 | 13.82 | 79 | 14553 | 393963 | 42212740 |
| Pinguecula | 13.84 | 13.82 | 3 | 14629 | 29 | 42606674 |
| Myositis | 13.82 | 13.82 | 21 | 14611 | 14845 | 42591858 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiac failure congestive | 108.44 | 12.34 | 157 | 26661 | 150843 | 110411638 |
| Rhabdomyolysis | 104.20 | 12.34 | 137 | 26681 | 120264 | 110442217 |
| Myalgia | 78.22 | 12.34 | 169 | 26649 | 222212 | 110340269 |
| Myocardial infarction | 69.87 | 12.34 | 148 | 26670 | 191935 | 110370546 |
| Blood glucose increased | 58.86 | 12.34 | 111 | 26707 | 132385 | 110430096 |
| Infusion related reaction | 52.12 | 12.34 | 14 | 26804 | 381148 | 110181333 |
| Cerebrovascular accident | 48.67 | 12.34 | 124 | 26694 | 181160 | 110381321 |
| Asthenia | 47.83 | 12.34 | 308 | 26510 | 688691 | 109873790 |
| Myasthenic syndrome | 47.44 | 12.34 | 16 | 26802 | 1260 | 110561221 |
| Off label use | 46.48 | 12.34 | 197 | 26621 | 1499988 | 109062493 |
| Atrial fibrillation | 43.96 | 12.34 | 139 | 26679 | 229503 | 110332978 |
| Myopathy | 43.51 | 12.34 | 41 | 26777 | 24919 | 110537562 |
| Pericarditis | 41.56 | 12.34 | 3 | 26815 | 219111 | 110343370 |
| General physical health deterioration | 38.73 | 12.34 | 28 | 26790 | 425267 | 110137214 |
| Coronary artery disease | 38.15 | 12.34 | 65 | 26753 | 71625 | 110490856 |
| Systemic lupus erythematosus | 37.39 | 12.34 | 8 | 26810 | 254330 | 110308151 |
| Dehydration | 37.06 | 12.34 | 150 | 26668 | 279361 | 110283120 |
| Death | 36.07 | 12.34 | 291 | 26527 | 698578 | 109863903 |
| Completed suicide | 35.31 | 12.34 | 134 | 26684 | 242247 | 110320234 |
| Lower respiratory tract infection | 35.02 | 12.34 | 8 | 26810 | 243098 | 110319383 |
| Treatment failure | 34.61 | 12.34 | 12 | 26806 | 277222 | 110285259 |
| Febrile neutropenia | 34.24 | 12.34 | 17 | 26801 | 316750 | 110245731 |
| Glossodynia | 32.60 | 12.34 | 7 | 26811 | 221997 | 110340484 |
| Drug abuse | 32.06 | 12.34 | 3 | 26815 | 177408 | 110385073 |
| Blood creatine phosphokinase increased | 30.93 | 12.34 | 60 | 26758 | 73017 | 110489464 |
| Contraindicated product administered | 30.55 | 12.34 | 11 | 26807 | 248256 | 110314225 |
| Renal failure | 28.76 | 12.34 | 120 | 26698 | 226454 | 110336027 |
| Irritable bowel syndrome | 26.65 | 12.34 | 4 | 26814 | 164211 | 110398270 |
| Feeling abnormal | 26.38 | 12.34 | 100 | 26718 | 180611 | 110381870 |
| Hand deformity | 26.35 | 12.34 | 10 | 26808 | 218496 | 110343985 |
| Wound | 26.22 | 12.34 | 12 | 26806 | 234425 | 110328056 |
| International normalised ratio increased | 26.07 | 12.34 | 62 | 26756 | 86710 | 110475771 |
| Fall | 24.24 | 12.34 | 238 | 26580 | 603244 | 109959237 |
| Muscle injury | 23.87 | 12.34 | 3 | 26815 | 140804 | 110421677 |
| Hypoglycaemia | 23.79 | 12.34 | 72 | 26746 | 116032 | 110446449 |
| Mental status changes | 23.53 | 12.34 | 55 | 26763 | 76067 | 110486414 |
| Plasma cell myeloma | 23.44 | 12.34 | 49 | 26769 | 62887 | 110499594 |
| Cardiovascular disorder | 23.00 | 12.34 | 28 | 26790 | 22732 | 110539749 |
| Gastrointestinal haemorrhage | 22.86 | 12.34 | 90 | 26728 | 165428 | 110397053 |
| Retroperitoneal oedema | 21.97 | 12.34 | 4 | 26814 | 21 | 110562460 |
| Neck mass | 21.93 | 12.34 | 14 | 26804 | 4807 | 110557674 |
| Product use in unapproved indication | 21.42 | 12.34 | 48 | 26770 | 447329 | 110115152 |
| Pyrexia | 20.87 | 12.34 | 130 | 26688 | 898135 | 109664346 |
| Liver disorder | 19.85 | 12.34 | 5 | 26813 | 142238 | 110420243 |
| Drug hypersensitivity | 19.66 | 12.34 | 182 | 26636 | 453908 | 110108573 |
| Sleep inertia | 19.63 | 12.34 | 4 | 26814 | 41 | 110562440 |
| Fatigue | 19.60 | 12.34 | 408 | 26410 | 1215550 | 109346931 |
| Chronic kidney disease | 19.24 | 12.34 | 51 | 26767 | 76240 | 110486241 |
| Impaired healing | 19.17 | 12.34 | 12 | 26806 | 196705 | 110365776 |
| Pain in extremity | 19.01 | 12.34 | 191 | 26627 | 486927 | 110075554 |
| C-reactive protein increased | 18.98 | 12.34 | 15 | 26803 | 217904 | 110344577 |
| Diverticulum | 18.86 | 12.34 | 21 | 26797 | 15505 | 110546976 |
| Product dose omission issue | 18.78 | 12.34 | 138 | 26680 | 321644 | 110240837 |
| Hypersensitivity | 18.01 | 12.34 | 45 | 26773 | 403953 | 110158528 |
| Rheumatoid arthritis | 18.00 | 12.34 | 28 | 26790 | 299585 | 110262896 |
| Intentional overdose | 17.84 | 12.34 | 5 | 26813 | 132496 | 110429985 |
| Vision blurred | 17.68 | 12.34 | 70 | 26748 | 128952 | 110433529 |
| Cardio-respiratory arrest | 17.65 | 12.34 | 65 | 26753 | 115771 | 110446710 |
| Blood urea increased | 17.30 | 12.34 | 40 | 26778 | 54917 | 110507564 |
| Right ventricular failure | 17.18 | 12.34 | 26 | 26792 | 25928 | 110536553 |
| Back disorder | 16.84 | 12.34 | 23 | 26795 | 20899 | 110541582 |
| Alopecia | 16.75 | 12.34 | 40 | 26778 | 364713 | 110197768 |
| Chronic obstructive pulmonary disease | 16.42 | 12.34 | 61 | 26757 | 109097 | 110453384 |
| Myositis | 16.27 | 12.34 | 28 | 26790 | 31088 | 110531393 |
| Discomfort | 16.06 | 12.34 | 17 | 26801 | 214690 | 110347791 |
| Inflammation | 15.97 | 12.34 | 14 | 26804 | 193224 | 110369257 |
| Renal injury | 15.72 | 12.34 | 21 | 26797 | 18692 | 110543789 |
| Hepatic enzyme increased | 15.70 | 12.34 | 34 | 26784 | 320858 | 110241623 |
| Bursitis | 15.57 | 12.34 | 6 | 26812 | 129912 | 110432569 |
| Wheezing | 15.18 | 12.34 | 24 | 26794 | 255206 | 110307275 |
| Epilepsy | 15.03 | 12.34 | 3 | 26815 | 100206 | 110462275 |
| Lung disorder | 14.93 | 12.34 | 13 | 26805 | 180034 | 110382447 |
| Potentiating drug interaction | 14.58 | 12.34 | 16 | 26802 | 11627 | 110550854 |
| Amyotrophic lateral sclerosis | 14.58 | 12.34 | 8 | 26810 | 2083 | 110560398 |
| Therapeutic product effect decreased | 14.51 | 12.34 | 23 | 26795 | 244293 | 110318188 |
| Arthropathy | 14.45 | 12.34 | 30 | 26788 | 287492 | 110274989 |
| Drug intolerance | 14.01 | 12.34 | 51 | 26767 | 406461 | 110156020 |
| Oedema peripheral | 13.85 | 12.34 | 131 | 26687 | 328529 | 110233952 |
| Migraine | 13.51 | 12.34 | 13 | 26805 | 171639 | 110390842 |
| Blood creatinine increased | 13.40 | 12.34 | 83 | 26735 | 182806 | 110379675 |
| Fibromyalgia | 13.39 | 12.34 | 13 | 26805 | 170896 | 110391585 |
| Psoriatic arthropathy | 13.19 | 12.34 | 17 | 26801 | 196744 | 110365737 |
| Product use issue | 12.91 | 12.34 | 36 | 26782 | 311659 | 110250822 |
| Corneal deposits | 12.86 | 12.34 | 5 | 26813 | 591 | 110561890 |
| Postmenopausal haemorrhage | 12.70 | 12.34 | 7 | 26811 | 1839 | 110560642 |
| Coronary artery bypass | 12.64 | 12.34 | 11 | 26807 | 6031 | 110556450 |
| Gastrointestinal injury | 12.50 | 12.34 | 7 | 26811 | 1896 | 110560585 |
| Back pain | 12.37 | 12.34 | 141 | 26677 | 370855 | 110191626 |
None
| Source | Code | Description |
|---|---|---|
| ATC | C10AA02 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN HMG CoA reductase inhibitors |
| ATC | C10BA01 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Combinations of various lipid modifying agents |
| FDA MoA | N0000000121 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| MeSH PA | D000924 | Anticholesteremic Agents |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| MeSH PA | D057847 | Lipid Regulating Agents |
| FDA EPC | N0000175589 | HMG-CoA Reductase Inhibitor |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:50266 | prodrug |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
| CHEBI has role | CHEBI:76956 | <em>Aspergillus </em> metabolite |
| CHEBI has role | CHEBI:145947 | antiatherosclerotic agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypercholesterolemia | indication | 13644009 | |
| Hyperlipidemia | indication | 55822004 | DOID:1168 |
| Arteriosclerotic vascular disease | indication | 72092001 | |
| Hypoalphalipoproteinemia | indication | 190785000 | |
| Familial hypercholesterolemia - heterozygous | indication | 238079002 | |
| Mixed hyperlipidemia | indication | 267434003 | |
| Hypertriglyceridemia | indication | 302870006 | |
| Myocardial Reinfarction Prevention | indication | ||
| Slow Progression of Coronary Artery Disease | indication | ||
| Primary Prevention of Coronary Heart Disease | indication | ||
| Myocardial Infarction Prevention | indication | ||
| Cerebrovascular accident | off-label use | 230690007 | |
| Prevention of Transient Ischemic Attacks | off-label use | ||
| Hypophosphatemia | contraindication | 4996001 | |
| Alcoholism | contraindication | 7200002 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Low blood pressure | contraindication | 45007003 | |
| Acute nephropathy | contraindication | 58574008 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Gout | contraindication | 90560007 | DOID:13189 |
| Disorder of muscle | contraindication | 129565002 | DOID:423 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Hemorrhagic cerebral infarction | contraindication | 230706003 | |
| Arterial hemorrhage | contraindication | 234003006 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Rhabdomyolysis | contraindication | 240131006 | |
| Pregnancy, function | contraindication | 289908002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Surgical procedure | contraindication | 387713003 | |
| Acute coronary syndrome | contraindication | 394659003 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Traumatic injury | contraindication | 417746004 | |
| Uncontrolled Epilepsy | contraindication |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | INHIBITOR | IC50 | 7.67 | WOMBAT-PK | CHEMBL | |||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.10 | DRUG MATRIX | |||||
| Adenosine receptor A1 | GPCR | Ki | 4.81 | DRUG MATRIX | |||||
| Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | AGONIST | EC50 | 6 | IUPHAR | ||||
| Hydroxycarboxylic acid receptor 2 | GPCR | IC50 | 7.30 | WOMBAT-PK | |||||
| Hydroxycarboxylic acid receptor 3 | GPCR | IC50 | 6.53 | WOMBAT-PK | |||||
| Histone deacetylase 2 | Enzyme | IC50 | 4.59 | CHEMBL | |||||
| Histone deacetylase 1 | Enzyme | IC50 | 4.92 | CHEMBL | |||||
| Histone deacetylase 6 | Enzyme | IC50 | 4.79 | CHEMBL | |||||
| Substance-K receptor | GPCR | Ki | 5.03 | DRUG MATRIX | |||||
| Leukocyte adhesion glycoprotein LFA-1 alpha | Adhesion | Kd | 4.89 | CHEMBL | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.06 | DRUG MATRIX | |||||
| Androgen receptor | Transcription factor | Ki | 4.70 | DRUG MATRIX | |||||
| Acetylcholinesterase | Enzyme | Ki | 5.57 | CHEMBL | |||||
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 8.52 | CHEMBL | |||||
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Enzyme | IC50 | 7.57 | CHEMBL | |||||
| Cholinesterase | Enzyme | Ki | 5.96 | CHEMBL | |||||
| Acyl-CoA:cholesterol acyltransferase | Enzyme | IC50 | 4.77 | CHEMBL |
| ID | Source |
|---|---|
| 4019482 | VUID |
| N0000147602 | NUI |
| D00359 | KEGG_DRUG |
| 4019482 | VANDF |
| C0024027 | UMLSCUI |
| CHEBI:40303 | CHEBI |
| 803 | PDB_CHEM_ID |
| CHEMBL503 | ChEMBL_ID |
| D008148 | MESH_DESCRIPTOR_UI |
| DB00227 | DRUGBANK_ID |
| 53232 | PUBCHEM_CID |
| 2739 | IUPHAR_LIGAND_ID |
| 6074 | INN_ID |
| 9LHU78OQFD | UNII |
| 224938 | RXNORM |
| 1105 | MMSL |
| 42628 | MMSL |
| 4998 | MMSL |
| d00280 | MMSL |
| 002063 | NDDF |
| 386024001 | SNOMEDCT_US |
| 96303004 | SNOMEDCT_US |
| 9LHU78OQFD | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0576 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0926 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0928 | TABLET | 40 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8151 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8152 | TABLET | 40 mg | ORAL | ANDA | 12 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-235 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-241 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-242 | TABLET | 40 mg | ORAL | ANDA | 22 sections |
| Lovastatin | Human Prescription Drug Label | 1 | 10544-246 | TABLET | 20 mg | ORAL | ANDA | 19 sections |
| LOVASTATIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-311 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-534 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-535 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-536 | TABLET | 40 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-547 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-548 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-549 | TABLET | 40 mg | ORAL | ANDA | 22 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-025 | TABLET | 40 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-028 | TABLET | 20 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-106 | TABLET | 10 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-493 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-548 | TABLET | 40 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-692 | TABLET | 20 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-939 | TABLET | 40 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-983 | TABLET | 20 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-763 | TABLET | 40 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0759 | TABLET | 20 mg | ORAL | ANDA | 12 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0761 | TABLET | 40 mg | ORAL | ANDA | 21 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0762 | TABLET | 40 mg | ORAL | ANDA | 12 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3216 | TABLET | 40 mg | ORAL | ANDA | 23 sections |
| Lovastatin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3268 | TABLET | 10 mg | ORAL | ANDA | 23 sections |