loperamide oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1600 106900-12-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loperamide oxide monohydrate
  • loperamide oxide
  • arestal
  • Molecular weight: 493.04
  • Formula: C29H33ClN2O3
  • CLOGP: 2.62
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -6.35
  • ROTB: 7

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.935 Moderate 0.70
caco2-efflux Caco-2 efflux ratio (BA/AB) 12.618 Moderate 0.70
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 8.035 10^-6 cm/s Moderate 0.70
dh-clint Dog hepatocyte intrinsic clearance 3.917 uL/min/10^6 cells Moderate 0.70
dppb Dog plasma protein binding (% unbound) 32.320 % Moderate 0.70
fcs-ppb Fetal calf serum protein binding (% unbound) 46.090 % Moderate 0.70
herg hERG pIC50 4.767 pIC50 Moderate 0.70
hh-clint Human hepatocyte intrinsic clearance 1.884 uL/min/10^6 cells Moderate 0.70
hlm-clint Human liver microsomal intrinsic clearance 15.205 uL/min/mg protein Moderate 0.70
hppb Human plasma protein binding (% unbound) 31.320 % Moderate 0.70
kinase-safety-class ACVR2B,AKT1,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK7,MET,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1 24
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 10.889 Moderate 0.70
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.036 Moderate 0.70
mh-clint Mouse hepatocyte intrinsic clearance 16.866 Moderate 0.70
mppb Mouse plasma protein binding (% unbound) 26.640 Moderate 0.70
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 17.219 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 42.400 % Moderate 0.70
rat-kpuu-brain Rat brain Kpuu 0.008 % Moderate 0.70
rh-clint Rat hepatocyte intrinsic clearance 26.363 uL/min/10^6 cells Moderate 0.70
rh-fuinc Rat hepatocyte fraction unbound in incubation 75.080 % Moderate 0.70
rppb Rat plasma protein binding (% unbound) 30.440 % Moderate 0.70
solubility-dd Solubility at pH 7.4 in DMSO 794.328 uM Moderate 0.70

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Mydriasis 47.66 46.08 11 261 22146 110566881

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07DA05 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
ANTIPROPULSIVES
Antipropulsives
MeSH PA D000930 Antidiarrheals
MeSH PA D005765 Gastrointestinal Agents

Related Drugs by ATC class:

A07DA Antipropulsives 5 drugs
difenoxindiphenoxylateeluxadolineloperamidemorphine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07113 KEGG_DRUG
C0083256 UMLSCUI
CHEBI:135795 CHEBI
CHEMBL2105114 ChEMBL_ID
DB14661 DRUGBANK_ID
C066043 MESH_SUPPLEMENTAL_RECORD_UI
6139 INN_ID
NG66S4H2RL UNII
71421 PUBCHEM_CID
007968 NDDF
1269134006 SNOMEDCT_US
735074004 SNOMEDCT_US

Pharmaceutical products:

None