difenoxin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
878 28782-42-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • difenoxin
  • difenoxin hydrochloride
  • difenoxilic acid
  • difenoxine
  • difenoxylic acid
  • diphenoxylic acid
  • lyspafen
  • difenoxin HCl
an orally administered antidiarrheal agent which is chemically related to the narcotic meperidine
  • Molecular weight: 424.54
  • Formula: C28H28N2O2
  • CLOGP: 2.13
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 64.33
  • ALOGS: -5.31
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1 37
kinase-selectivity-class AXL,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4,PIK3CD,SIK2 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 14, 1978 FDA SEBELA IRELAND LTD

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07DA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
ANTIPROPULSIVES
Antipropulsives
CHEBI has role CHEBI:55323 antidiarrhoeal drug
FDA EPC N0000178374 Antidiarrheal

Related Drugs by ATC class:

A07DA Antipropulsives 5 drugs
diphenoxylateeluxadolineloperamideloperamide oxidemorphine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diarrhea indication 62315008
Brain damage contraindication 2470005
Tachyarrhythmia contraindication 6285003
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Severe chronic ulcerative colitis contraindication 14311001
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Ulcerative colitis contraindication 64766004 DOID:8577
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Hiatal hernia contraindication 84089009 DOID:12642
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Gastrointestinal obstruction contraindication 126765001
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Liver function tests abnormal contraindication 166603001
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Angle-closure glaucoma contraindication 392291006 DOID:13550
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.39 acidic
pKa2 7.51 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

IDSource
4019718 VUID
N0000179105 NUI
D03809 KEGG_DRUG
35607-36-4 SECONDARY_CAS_RN
23024 RXNORM
4019431 VANDF
4019718 VANDF
C0057981 UMLSCUI
CHEBI:4534 CHEBI
CHEMBL1201321 ChEMBL_ID
CHEMBL1200599 ChEMBL_ID
DB01501 DRUGBANK_ID
C100010 MESH_SUPPLEMENTAL_RECORD_UI
34328 PUBCHEM_CID
7592 IUPHAR_LIGAND_ID
2903 INN_ID
3ZZ5BJ9F2Q UNII
4593 MMSL
d03069 MMSL
001161 NDDF
001162 NDDF
387029001 SNOMEDCT_US
767928009 SNOMEDCT_US
C028792 MESH_SUPPLEMENTAL_RECORD_UI
3ZZ5BJ9F2Q INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Motofen HUMAN PRESCRIPTION DRUG LABEL 2 54766-200 TABLET 1 mg ORAL NDA 18 sections
Motofen HUMAN PRESCRIPTION DRUG LABEL 2 54766-200 TABLET 1 mg ORAL NDA 18 sections
Motofen HUMAN PRESCRIPTION DRUG LABEL 2 83107-011 TABLET 1 mg ORAL NDA 18 sections