levetiracetam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
amide type nootrope agents, piracetam derivatives 1563 102767-28-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • keppra
  • levetiracetam
  • matever
  • (-)-Levetiracetam
  • levroxa
  • UCB-6474
  • UCB 6474
The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Levetiracetam also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. In vitro and in vivo recordings of epileptiform activity from the hippocampus have shown that levetiracetam inhibits burst firing without affecting normal neuronal excitability, suggesting that levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam at concentrations of up to 10 uM did not demonstrate binding affinity for a variety of known receptors, such as those associated with benzodiazepines, GABA (gamma-aminobutyric acid), glycine, NMDA (N-methyl-D-aspartate), re-uptake sites, and second messenger systems. Furthermore, in vitro studies have failed to find an effect of levetiracetam on neuronal voltage-gated sodium or T-type calcium currents and levetiracetam does not appear to directly facilitate GABAergic neurotransmission. However, in vitro studies have demonstrated that levetiracetam opposes the activity of negative modulators of GABA- and glycine-gated currents and partially inhibits N-type calcium currents in neuronal cells. A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetam. Experimental data indicate that this binding site is the synaptic vesicle protein SV2A, thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice. These findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.
  • Molecular weight: 170.21
  • Formula: C8H14N2O2
  • CLOGP: -0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.40
  • ALOGS: 0.24
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1040 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 251.79 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.90 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.23 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.573 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.733 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 27.861 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.410 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 91.410 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 92.120 % High 1
herg hERG pIC50 3.751 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.061 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.148 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 90.680 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PRKDC,SIK2,STK33,TEK 25
kinase-selectivity-class ACVR2B,GRK2,STK33 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.685 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.867 High 1
mh-clint Mouse hepatocyte intrinsic clearance 0.495 High 1
mppb Mouse plasma protein binding (% unbound) 96.120 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.884 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 97.160 % High 1
rat-kpuu-brain Rat brain Kpuu 0.350 % High 1
rh-clint Rat hepatocyte intrinsic clearance 0.822 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 96.500 % High 1
rppb Rat plasma protein binding (% unbound) 95.640 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 933.254 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 2000 EMA
Nov. 30, 1999 FDA UCB INC
July 23, 2010 PMDA UCB Japan Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 7691.96 11.19 4030 136170 148599 90339648
Abortion spontaneous 3034.65 11.19 1539 138661 52517 90435730
Status epilepticus 2896.11 11.19 1092 139108 17782 90470465
Multiple-drug resistance 1960.74 11.19 651 139549 7125 90481122
Generalised tonic-clonic seizure 1891.66 11.19 971 139229 33932 90454315
Maternal exposure during pregnancy 1336.39 11.19 2162 138038 357901 90130346
Pregnancy 1121.63 11.19 859 139341 61188 90427059
Partial seizures 1008.81 11.19 391 139809 6869 90481378
Epilepsy 903.33 11.19 855 139345 81351 90406896
Aggression 885.77 11.19 538 139662 26130 90462117
Petit mal epilepsy 717.28 11.19 275 139925 4683 90483564
Drug reaction with eosinophilia and systemic symptoms 698.95 11.19 558 139642 42200 90446047
Exposure during pregnancy 669.57 11.19 1268 138932 237142 90251105
Drug ineffective 660.92 11.19 4012 136188 1380286 89107961
Product substitution issue 638.65 11.19 379 139821 17629 90470618
Stillbirth 615.75 11.19 277 139923 7166 90481081
Focal dyscognitive seizures 612.21 11.19 217 139983 2927 90485320
Foetal exposure during pregnancy 526.12 11.19 475 139725 42500 90445747
Arthralgia 523.34 11.19 277 139923 778245 89710002
Psychogenic seizure 516.95 11.19 171 140029 1845 90486402
Somnolence 510.54 11.19 1049 139151 208035 90280212
Drug resistance 503.19 11.19 400 139800 30049 90458198
Joint swelling 500.45 11.19 88 140112 503212 89985035
Irritability 498.38 11.19 425 139775 35237 90453010
Drug interaction 484.59 11.19 1216 138984 275237 90213010
Synovitis 478.37 11.19 6 140194 329746 90158501
Arthropathy 477.44 11.19 21 140179 366221 90122026
Rheumatoid arthritis 472.01 11.19 21 140179 362593 90125654
Pain 466.65 11.19 514 139686 995827 89492420
Abortion induced 455.27 11.19 263 139937 11625 90476622
Infusion related reaction 436.44 11.19 63 140137 416717 90071530
Abdominal discomfort 432.00 11.19 104 140096 477224 90011023
Glossodynia 424.20 11.19 17 140183 321762 90166485
Contraindicated product administered 405.54 11.19 22 140178 320117 90168130
Myoclonic epilepsy 397.23 11.19 133 140067 1494 90486753
Swelling 395.81 11.19 83 140117 418975 90069272
Pericarditis 382.90 11.19 7 140193 270144 90218103
Anticonvulsant drug level increased 361.64 11.19 126 140074 1610 90486637
Behaviour disorder 359.70 11.19 165 140035 4470 90483777
Agitation 356.28 11.19 478 139722 66620 90421627
Paradoxical drug reaction 354.91 11.19 175 140025 5591 90482656
Systemic lupus erythematosus 353.61 11.19 66 140134 361830 90126417
Anticonvulsant drug level decreased 344.01 11.19 115 140085 1285 90486962
Helicobacter infection 334.08 11.19 3 140197 226847 90261400
Abnormal behaviour 331.20 11.19 277 139923 22351 90465896
Premature delivery 329.50 11.19 351 139849 38411 90449836
Duodenal ulcer perforation 325.53 11.19 3 140197 221285 90266962
Peripheral swelling 314.34 11.19 123 140077 412983 90075264
Drug ineffective for unapproved indication 313.69 11.19 448 139752 66196 90422051
Psychotic disorder 311.10 11.19 308 139892 30922 90457325
Wound 309.68 11.19 49 140151 302931 90185316
Cytokine release syndrome 307.08 11.19 291 139909 27682 90460565
Psoriatic arthropathy 304.49 11.19 11 140189 228324 90259923
Encephalopathy 303.67 11.19 367 139833 46077 90442170
Sinusitis 300.09 11.19 80 140120 343008 90145239
Folliculitis 295.00 11.19 4 140196 204349 90283898
Toxicity to various agents 292.15 11.19 1044 139156 286802 90201445
Rhabdomyolysis 291.96 11.19 378 139822 50878 90437369
Thrombocytopenia 290.81 11.19 844 139356 207881 90280366
Discomfort 285.77 11.19 42 140158 274293 90213954
Myoclonus 285.41 11.19 237 139963 18931 90469316
Impaired healing 284.78 11.19 20 140180 234179 90254068
Change in seizure presentation 283.01 11.19 81 140119 511 90487736
Sudden unexplained death in epilepsy 279.21 11.19 74 140126 334 90487913
Dyspnoea 278.50 11.19 593 139607 880362 89607885
Alopecia 277.55 11.19 216 139984 494855 89993392
Lower respiratory tract infection 273.91 11.19 33 140167 250626 90237621
Irritable bowel syndrome 273.15 11.19 11 140189 207437 90280810
Overdose 264.77 11.19 683 139517 157026 90331221
Ataxia 264.33 11.19 221 139979 17821 90470426
Off label use 258.11 11.19 2718 137482 1099534 89388713
Drug withdrawal convulsions 256.29 11.19 94 140106 1406 90486841
Nasopharyngitis 236.60 11.19 171 140029 406933 90081314
Stevens-Johnson syndrome 233.88 11.19 257 139943 29119 90459128
Osteoarthritis 228.73 11.19 20 140180 195710 90292537
Caesarean section 228.60 11.19 206 139994 18371 90469876
Therapeutic product effect decreased 227.50 11.19 73 140127 277498 90210749
Hypersensitivity 227.35 11.19 221 139979 454456 90033791
Immune effector cell-associated neurotoxicity syndrome 221.89 11.19 128 140072 5640 90482607
Musculoskeletal stiffness 221.01 11.19 91 140109 296441 90191806
Fibromyalgia 220.85 11.19 29 140171 206240 90282007
Cognitive disorder 215.55 11.19 386 139814 69021 90419226
Blood cholesterol increased 213.93 11.19 33 140167 207979 90280268
Electroencephalogram abnormal 213.19 11.19 111 140089 3985 90484262
Wheezing 212.91 11.19 53 140147 238027 90250220
Tonic convulsion 204.39 11.19 83 140117 1655 90486592
Partial seizures with secondary generalisation 203.18 11.19 60 140140 429 90487818
Drug intolerance 199.92 11.19 239 139961 447352 90040895
Seizure cluster 198.47 11.19 56 140144 333 90487914
Hepatic enzyme increased 195.00 11.19 163 140037 360573 90127674
Maternal exposure before pregnancy 193.16 11.19 151 140049 11062 90477185
Pain in extremity 190.33 11.19 251 139949 450278 90037969
Maternal exposure during breast feeding 184.94 11.19 117 140083 6103 90482144
Infection 184.43 11.19 173 140027 361921 90126326
Small for dates baby 184.36 11.19 108 140092 4899 90483348
Infantile spasms 183.81 11.19 48 140152 202 90488045
Suicidal ideation 180.45 11.19 371 139829 73484 90414763
Asthma 179.31 11.19 75 140125 242085 90246162
Hyperammonaemic encephalopathy 178.36 11.19 86 140114 2613 90485634
Aura 177.80 11.19 68 140132 1149 90487098
Joint range of motion decreased 175.85 11.19 8 140192 135635 90352612
Aphasia 170.21 11.19 266 139934 42546 90445701
Hallucination, visual 170.07 11.19 194 140006 22898 90465349
Drug hypersensitivity 168.00 11.19 287 139913 463322 90024925
Hypertension 167.86 11.19 281 139919 457251 90030996
Mobility decreased 166.72 11.19 90 140110 250644 90237603
Aplastic anaemia 164.96 11.19 148 140052 13121 90475126
Ill-defined disorder 163.66 11.19 42 140158 184849 90303398
Gastrointestinal disorder 162.29 11.19 98 140102 256589 90231658
Disturbance in attention 161.90 11.19 274 139926 46835 90441412
Inflammation 161.12 11.19 39 140161 178553 90309694
Toxic epidermal necrolysis 159.42 11.19 223 139977 32305 90455942
Hyperammonaemia 158.86 11.19 108 140092 6367 90481880
Stomatitis 158.68 11.19 116 140084 274582 90213665
Bursitis 157.82 11.19 12 140188 131642 90356605
Type 2 diabetes mellitus 155.26 11.19 60 140140 203184 90285063
Atonic seizures 153.86 11.19 55 140145 761 90487486
Depressed level of consciousness 152.98 11.19 344 139856 72440 90415807
No adverse event 152.72 11.19 330 139870 67652 90420595
Psychomotor hyperactivity 151.60 11.19 139 140061 12674 90475573
Low birth weight baby 149.20 11.19 121 140079 9346 90478901
Anger 147.27 11.19 141 140059 13579 90474668
Abdominal pain upper 147.00 11.19 179 140021 332495 90155752
Malaise 144.22 11.19 447 139753 585539 89902708
Night sweats 142.97 11.19 16 140184 128750 90359497
Diarrhoea 142.67 11.19 861 139339 938329 89549918
Intentional overdose 141.81 11.19 391 139809 93443 90394804
Brain oedema 141.69 11.19 154 140046 17231 90471016
Pruritus 141.24 11.19 402 139798 541123 89947124
Hallucination 141.15 11.19 314 139886 65645 90422602
Suicide attempt 139.50 11.19 339 139861 75060 90413187
Altered state of consciousness 138.19 11.19 205 139995 31327 90456920
Acute generalised exanthematous pustulosis 138.03 11.19 136 140064 13567 90474680
Substance-induced psychotic disorder 137.64 11.19 74 140126 2838 90485409
Musculoskeletal pain 135.09 11.19 48 140152 171203 90317044
Coma 134.84 11.19 327 139873 72305 90415942
Pulmonary fibrosis 134.12 11.19 8 140192 107495 90380752
Drug level increased 134.08 11.19 189 140011 27573 90460674
Maternal drugs affecting foetus 133.70 11.19 89 140111 5066 90483181
Premature baby 132.05 11.19 178 140022 24899 90463348
Encephalitis autoimmune 131.25 11.19 64 140136 1994 90486253
Neurotoxicity 131.19 11.19 164 140036 21303 90466944
Arthritis 130.11 11.19 48 140152 167267 90320980
Simple partial seizures 129.07 11.19 47 140153 688 90487559
Sciatica 128.15 11.19 7 140193 101375 90386872
Lip dry 127.52 11.19 7 140193 100948 90387299
Exposure via breast milk 127.01 11.19 65 140135 2250 90485997
Blister 126.08 11.19 125 140075 254873 90233374
Anticonvulsant drug level above therapeutic 125.10 11.19 43 140157 526 90487721
Mood altered 124.51 11.19 143 140057 17001 90471246
Treatment noncompliance 124.17 11.19 258 139942 51469 90436778
Hallucination, auditory 124.11 11.19 138 140062 15837 90472410
Hyponatraemia 123.19 11.19 470 139730 133068 90355179
Nausea 122.16 11.19 1115 139085 1109201 89379046
Mental status changes 121.80 11.19 235 139965 44444 90443803
Grip strength decreased 121.51 11.19 5 140195 92571 90395676
Propofol infusion syndrome 120.91 11.19 53 140147 1286 90486961
Breast feeding 120.67 11.19 47 140153 836 90487411
Dyspepsia 119.26 11.19 80 140120 198080 90290167
Ventricular fibrillation 119.01 11.19 127 140073 13917 90474330
Posterior reversible encephalopathy syndrome 118.29 11.19 159 140041 22180 90466067
Pancytopenia 118.20 11.19 432 139768 119831 90368416
Bradycardia 116.55 11.19 339 139861 83508 90404739
Electrocardiogram QT prolonged 115.56 11.19 308 139892 72148 90416099
Wound infection 113.75 11.19 15 140185 106387 90381860
Anticonvulsant drug level below therapeutic 112.96 11.19 42 140158 654 90487593
Psoriasis 112.20 11.19 44 140156 147710 90340537
Injury 111.78 11.19 85 140115 197264 90290983
Cardiac arrest 111.73 11.19 387 139813 104548 90383699
Hypotonia 110.65 11.19 111 140089 11315 90476932
Dry mouth 109.84 11.19 75 140125 183984 90304263
Cholestasis 109.00 11.19 199 140001 36100 90452147
Red blood cell sedimentation rate increased 106.62 11.19 5 140195 82590 90405657
Delusion 106.56 11.19 119 140081 13721 90474526
Leukopenia 105.99 11.19 370 139830 100340 90387907
Speech disorder 105.49 11.19 224 139976 45361 90442886
Intentional product use issue 105.29 11.19 108 140092 216784 90271463
Injection site pain 104.69 11.19 70 140130 173629 90314618
Drug level decreased 104.44 11.19 100 140100 9630 90478617
Knee arthroplasty 104.34 11.19 6 140194 83176 90405071
Affective disorder 103.00 11.19 90 140110 7703 90480544
Nystagmus 102.71 11.19 87 140113 7140 90481107
Urticaria 102.19 11.19 206 139994 312528 90175719
Oedema 101.53 11.19 96 140104 200199 90288048
Disorientation 101.20 11.19 216 139984 43898 90444349
Brain neoplasm 100.42 11.19 73 140127 4791 90483456
Foetal growth restriction 99.92 11.19 96 140104 9284 90478963
Fatigue 97.76 11.19 1231 138969 1152792 89335455
Hypercholesterolaemia 95.05 11.19 20 140180 100872 90387375
Sopor 95.01 11.19 151 140049 24493 90463754
Hepatocellular injury 94.98 11.19 165 140035 28793 90459454
Hip arthroplasty 94.07 11.19 6 140194 76202 90412045
Chest pain 93.37 11.19 224 139976 319421 90168826
Ventricular tachycardia 93.35 11.19 150 140050 24558 90463689
Tremor 93.19 11.19 476 139724 152697 90335550
Contusion 92.27 11.19 154 140046 251062 90237185
Intellectual disability 91.15 11.19 43 140157 1243 90487004
Weight increased 90.96 11.19 336 139864 417591 90070656
Glioblastoma multiforme 90.82 11.19 39 140161 899 90487348
Hypoaesthesia 89.56 11.19 223 139977 313987 90174260
Diplopia 88.23 11.19 159 140041 28555 90459692
Cerebral haemorrhage 87.35 11.19 176 140024 34346 90453901
Hemiparesis 86.29 11.19 167 140033 31652 90456595
Lower limb fracture 86.20 11.19 14 140186 84999 90403248
Persecutory delusion 84.68 11.19 56 140144 3152 90485095
Respiratory disorder neonatal 84.67 11.19 42 140158 1359 90486888
Central nervous system lesion 84.33 11.19 97 140103 11549 90476698
Agranulocytosis 83.32 11.19 174 140026 34828 90453419
Mood swings 82.79 11.19 129 140071 20573 90467674
Weight gain poor 82.49 11.19 39 140161 1133 90487114
Obesity 82.46 11.19 30 140170 105477 90382770
C-reactive protein increased 81.76 11.19 96 140104 181293 90306954
Pleocytosis 81.73 11.19 37 140163 971 90487276
Intra-abdominal pressure increased 79.91 11.19 26 140174 265 90487982
Hypoventilation 79.91 11.19 66 140134 5230 90483017
Mitochondrial DNA mutation 79.36 11.19 29 140171 429 90487818
Joint stiffness 78.80 11.19 13 140187 78029 90410218
Hepatic cytolysis 77.49 11.19 157 140043 30759 90457488
Epileptic aura 77.25 11.19 19 140181 59 90488188
Muscle spasms 77.17 11.19 172 140028 251711 90236536
Oedema peripheral 76.68 11.19 179 140021 257736 90230511
Respiratory failure 76.26 11.19 374 139826 118044 90370203
Liver injury 75.03 11.19 92 140108 170475 90317772
Depressed mood 74.59 11.19 208 139992 50014 90438233
Personality change 74.37 11.19 73 140127 7248 90480999
Apnoea 74.29 11.19 82 140118 9332 90478915
Rash 74.21 11.19 831 139369 795269 89692978
Dyskinesia 73.78 11.19 170 140030 36364 90451883
Back pain 73.66 11.19 248 139952 316927 90171320
Dysarthria 73.52 11.19 218 139982 54264 90433983
Febrile convulsion 73.28 11.19 29 140171 539 90487708
Acute psychosis 72.34 11.19 50 140150 3028 90485219
Selective eating disorder 72.22 11.19 43 140157 2010 90486237
Gait inability 72.11 11.19 72 140128 146384 90341863
Intentional self-injury 71.20 11.19 147 140053 29187 90459060
Paranoia 70.06 11.19 93 140107 12815 90475432
Autoimmune disorder 68.72 11.19 17 140183 76727 90411520
Product administration error 68.40 11.19 136 140064 26287 90461960
Toxic skin eruption 68.32 11.19 102 140098 15672 90472575
Cough 68.17 11.19 316 139884 368646 90119601
Eosinophilia 68.10 11.19 142 140058 28391 90459856
Congenital cyst 66.94 11.19 14 140186 14 90488233
Acute hepatic failure 66.87 11.19 123 140077 22438 90465809
Osteoporosis 66.56 11.19 33 140167 96498 90391749
General physical health deterioration 66.28 11.19 303 139897 354812 90133435
Injection site reaction 65.76 11.19 30 140170 92050 90396197
Multiple organ dysfunction syndrome 65.04 11.19 243 139957 68093 90420154
Mental disorder 64.84 11.19 150 140050 32168 90456079
Gastrooesophageal reflux disease 64.81 11.19 98 140102 166239 90322008
Lung disorder 64.71 11.19 82 140118 149801 90338446
Teratogenicity 64.01 11.19 22 140178 269 90487978
Intracranial tumour haemorrhage 63.03 11.19 21 140179 232 90488015
Glioblastoma 62.17 11.19 30 140170 913 90487334
Hemianopia 61.49 11.19 39 140161 2043 90486204
Haemophagocytic lymphohistiocytosis 61.36 11.19 96 140104 15363 90472884
Suicidal behaviour 59.43 11.19 43 140157 2801 90485446
Postictal state 59.21 11.19 33 140167 1360 90486887
Onychomadesis 58.68 11.19 3 140197 45995 90442252
Hypertransaminasaemia 58.32 11.19 95 140105 15730 90472517
Abdominal pain 58.13 11.19 366 139834 395355 90092892
Metabolic acidosis 58.08 11.19 204 139996 55472 90432775
Exostosis 57.98 11.19 7 140193 53127 90435120
Bradycardia neonatal 57.97 11.19 30 140170 1063 90487184
Epileptic encephalopathy 57.78 11.19 22 140178 367 90487880
Pre-eclampsia 57.52 11.19 78 140122 10970 90477277
Hypomagnesaemia 57.45 11.19 152 140048 35436 90452811
Pneumonia aspiration 57.33 11.19 166 140034 40774 90447473
Lethargy 57.18 11.19 221 139979 62918 90425329
Pneumatosis 57.13 11.19 23 140177 448 90487799
Excessive eye blinking 56.95 11.19 32 140168 1340 90486907
Mutism 56.94 11.19 35 140165 1734 90486513
Suppressed lactation 56.85 11.19 23 140177 454 90487793
Rash maculo-papular 56.38 11.19 165 140035 40768 90447479
Dysmorphism 56.36 11.19 40 140160 2528 90485719
Wrong product administered 55.77 11.19 64 140136 7601 90480646
Developmental delay 55.65 11.19 34 140166 1666 90486581
Encephalitis 55.54 11.19 77 140123 11057 90477190
X-ray abnormal 54.82 11.19 4 140196 45420 90442827
Lymphopenia 54.75 11.19 114 140086 22767 90465480
Bradyphrenia 54.44 11.19 63 140137 7549 90480698
Bronchitis 54.06 11.19 96 140104 152831 90335416
Hypothermia 54.04 11.19 91 140109 15484 90472763
Cerebellar ataxia 53.83 11.19 27 140173 895 90487352
Autoimmune hepatitis 53.77 11.19 73 140127 10278 90477969
Fluid retention 53.74 11.19 35 140165 88056 90400191
Loss of personal independence in daily activities 53.20 11.19 80 140120 136025 90352222
Granuloma annulare 53.08 11.19 26 140174 818 90487429
Brain operation 52.83 11.19 24 140176 635 90487612
Unresponsive to stimuli 52.83 11.19 154 140046 37967 90450280
Metastases to central nervous system 52.45 11.19 96 140104 17446 90470801
Toxic encephalopathy 52.42 11.19 66 140134 8633 90479614
Loss of consciousness 52.31 11.19 384 139816 139854 90348393
Learning disorder 52.11 11.19 26 140174 852 90487395
Necrosis ischaemic 51.88 11.19 27 140173 968 90487279
Metabolic encephalopathy 51.88 11.19 58 140142 6694 90481553
Apathy 51.59 11.19 74 140126 10966 90477281
Upper respiratory tract infection 51.54 11.19 74 140126 128244 90360003
Injection site erythema 51.33 11.19 46 140154 98456 90389791
CSF oligoclonal band present 51.19 11.19 21 140179 430 90487817
Respiratory acidosis 51.16 11.19 63 140137 8056 90480191
Thinking abnormal 51.00 11.19 76 140124 11656 90476591
Screaming 50.96 11.19 44 140156 3706 90484541
Post stroke depression 50.76 11.19 11 140189 15 90488232
Myocardial depression 50.58 11.19 23 140177 610 90487637
Automatism epileptic 50.41 11.19 12 140188 31 90488216
Feeling hot 50.36 11.19 29 140171 77979 90410268
Idiopathic generalised epilepsy 50.04 11.19 10 140190 6 90488241
Chest discomfort 49.69 11.19 86 140114 138279 90349968
Ammonia increased 49.32 11.19 49 140151 4937 90483310
Anticoagulation drug level abnormal 49.21 11.19 15 140185 121 90488126
Macroglossia 49.15 11.19 25 140175 854 90487393
Postictal paralysis 48.97 11.19 18 140182 271 90487976
Eye movement disorder 48.93 11.19 54 140146 6144 90482103
Back injury 48.81 11.19 7 140193 46615 90441632
Staring 48.62 11.19 31 140169 1639 90486608
Deja vu 48.58 11.19 15 140185 127 90488120
Hippocampal sclerosis 48.56 11.19 14 140186 91 90488156
Road traffic accident 48.44 11.19 57 140143 107569 90380678
Disease recurrence 48.29 11.19 148 140052 37505 90450742
Lennox-Gastaut syndrome 48.02 11.19 18 140182 287 90487960
Therapeutic response unexpected 47.74 11.19 105 140095 21775 90466472
Migraine 47.57 11.19 144 140056 190248 90297999
Fall 47.51 11.19 1026 139174 480784 90007463
Eosinophilic pleural effusion 46.81 11.19 15 140185 145 90488102
Atrioventricular block complete 46.20 11.19 66 140134 9745 90478502
Choroidal effusion 45.75 11.19 23 140177 766 90487481
Taste disorder 45.61 11.19 19 140181 61527 90426720
Restlessness 45.43 11.19 140 140060 35580 90452667
Neurological decompensation 45.40 11.19 40 140160 3461 90484786
Torsade de pointes 45.28 11.19 83 140117 15099 90473148
Head injury 45.16 11.19 128 140072 31060 90457187
Cerebral salt-wasting syndrome 45.12 11.19 16 140184 216 90488031
Major depression 45.05 11.19 66 140134 9969 90478278
Blood creatine phosphokinase increased 44.82 11.19 135 140065 33888 90454359
Blood pressure increased 44.53 11.19 156 140044 197061 90291186
Injection site pruritus 44.33 11.19 14 140186 53820 90434427
Obsessive-compulsive disorder 44.06 11.19 44 140156 4460 90483787
Retrograde amnesia 43.86 11.19 20 140180 534 90487713
Precocious puberty 43.56 11.19 17 140183 304 90487943
Onychomycosis 43.15 11.19 4 140196 37372 90450875
Gingival hypertrophy 43.12 11.19 32 140168 2168 90486079
Magnetic resonance imaging head abnormal 43.11 11.19 34 140166 2522 90485725
Crystal nephropathy 42.83 11.19 25 140175 1126 90487121
Autism spectrum disorder 42.69 11.19 26 140174 1267 90486980
Abortion 42.52 11.19 35 140165 2760 90485487
Blood gases abnormal 42.40 11.19 23 140177 898 90487349
Developmental regression 42.24 11.19 10 140190 25 90488222
Temporal lobe epilepsy 42.23 11.19 18 140182 407 90487840
Nasal congestion 42.22 11.19 40 140160 83374 90404873
Affect lability 42.06 11.19 89 140111 17974 90470273
Accidental overdose 41.88 11.19 117 140083 28156 90460091
Gene mutation 41.79 11.19 31 140169 2099 90486148
Muscle twitching 41.77 11.19 106 140094 24096 90464151
Coeliac disease 41.69 11.19 9 140191 44601 90443646
Neck pain 41.68 11.19 70 140130 113893 90374354
Hypotension 41.60 11.19 721 139479 324676 90163571
Cardiac failure congestive 41.56 11.19 55 140145 98639 90389608
Frequent bowel movements 41.51 11.19 18 140182 56917 90431330
Macular degeneration 41.43 11.19 5 140195 37965 90450282
Automatism 41.36 11.19 12 140188 80 90488167
Product name confusion 41.30 11.19 13 140187 118 90488129
Product packaging confusion 41.29 11.19 15 140185 218 90488029
Malignant catatonia 41.10 11.19 15 140185 221 90488026
Drug clearance increased 40.98 11.19 15 140185 223 90488024
Erythema multiforme 40.44 11.19 70 140130 12176 90476071
Developmental glaucoma 40.42 11.19 11 140189 56 90488191
Organic brain syndrome 40.26 11.19 15 140185 235 90488012
Exomphalos 40.25 11.19 19 140181 550 90487697
Vasoplegia syndrome 40.24 11.19 34 140166 2780 90485467
JC polyomavirus test 39.97 11.19 10 140190 34 90488213
Cross sensitivity reaction 39.79 11.19 34 140166 2823 90485424
Meningioma 39.72 11.19 44 140156 5027 90483220
Paraesthesia 39.63 11.19 226 139974 250100 90238147
Tongue biting 39.52 11.19 30 140170 2103 90486144
Nail disorder 39.51 11.19 21 140179 59046 90429201
Hyperthermia 39.39 11.19 63 140137 10272 90477975
Neuropsychiatric symptoms 39.38 11.19 20 140180 681 90487566
Brain herniation 39.20 11.19 40 140160 4160 90484087
Accidental poisoning 38.79 11.19 22 140178 938 90487309
Verbal abuse 38.72 11.19 12 140188 103 90488144
Electrocardiogram QRS complex prolonged 38.44 11.19 52 140148 7296 90480951
Parkinsonism 38.35 11.19 74 140126 13991 90474256
Clonic convulsion 38.27 11.19 21 140179 839 90487408
Congenital knee dislocation 38.25 11.19 8 140192 8 90488239
Dystonia 38.16 11.19 82 140118 16737 90471510
Mania 38.13 11.19 74 140126 14050 90474197
Angiofibroma 38.12 11.19 12 140188 109 90488138
Colitis ulcerative 38.06 11.19 23 140177 60243 90428004
Hydrocephalus 37.94 11.19 47 140153 6047 90482200
Limbic encephalitis 37.85 11.19 15 140185 280 90487967
Spina bifida 37.82 11.19 21 140179 859 90487388
Trisomy 21 37.73 11.19 17 140183 441 90487806
Mitochondrial toxicity 37.49 11.19 19 140181 644 90487603
Retinogram abnormal 37.39 11.19 13 140187 165 90488082
Aspiration 37.33 11.19 78 140122 15615 90472632
Malabsorption 37.28 11.19 43 140157 5135 90483112
Pemphigoid 37.15 11.19 57 140143 8969 90479278
Laryngitis 37.08 11.19 16 140184 50737 90437510
Creutzfeldt-Jakob disease 36.69 11.19 13 140187 175 90488072
Foot deformity 35.97 11.19 24 140176 59627 90428620
Hypertonia 35.76 11.19 42 140158 5113 90483134
Brief psychotic disorder, with postpartum onset 35.66 11.19 9 140191 32 90488215
Intraventricular haemorrhage neonatal 35.54 11.19 14 140186 257 90487990
Hemianopia homonymous 35.43 11.19 20 140180 845 90487402
Dry eye 35.35 11.19 23 140177 57908 90430339
Disease progression 35.20 11.19 384 139816 156231 90332016
Transaminases increased 35.17 11.19 132 140068 37060 90451187
White matter lesion 35.11 11.19 30 140170 2491 90485756
Kounis syndrome 34.78 11.19 30 140170 2523 90485724
Lupus-like syndrome 34.74 11.19 16 140184 48830 90439417
Angle closure glaucoma 34.58 11.19 31 140169 2744 90485503
Blood pressure systolic increased 34.48 11.19 24 140176 58321 90429926
Sleep disorder due to a general medical condition 34.48 11.19 13 140187 44725 90443522
Finger deformity 34.30 11.19 5 140195 32892 90455355
Hypernatraemia 34.11 11.19 56 140144 9331 90478916
Crying 34.01 11.19 102 140098 25543 90462704
Unintended pregnancy 33.96 11.19 50 140150 7587 90480660
Cell death 33.93 11.19 32 140168 3023 90485224
Axillary lymphadenectomy 33.82 11.19 11 140189 112 90488135
Twin pregnancy 33.54 11.19 22 140178 1221 90487026
Ear infection 33.54 11.19 35 140165 69740 90418507
Psychomotor retardation 33.19 11.19 39 140161 4750 90483497
Subdural haematoma 33.10 11.19 77 140123 16568 90471679
Anorectal malformation 33.03 11.19 13 140187 238 90488009
Circulatory collapse 32.97 11.19 99 140101 24805 90463442
Wrong patient 32.91 11.19 19 140181 838 90487409
Neurosurgery 32.88 11.19 10 140190 80 90488167
Amniotic band syndrome 32.84 11.19 6 140194 0 90488247
COVID-19 32.71 11.19 142 140058 168701 90319546
Cataract 32.63 11.19 38 140162 72054 90416193
Hepatic cirrhosis 32.40 11.19 30 140170 63223 90425024
Injection site swelling 32.32 11.19 27 140173 59812 90428435
Skin ulcer 31.78 11.19 19 140181 50056 90438191
Haematoma 31.61 11.19 132 140068 38916 90449331
Hereditary optic atrophy 31.58 11.19 8 140192 29 90488218
MELAS syndrome 31.31 11.19 12 140188 204 90488043
Gamma-glutamyltransferase increased 31.28 11.19 129 140071 37823 90450424
Premature labour 31.25 11.19 66 140134 13310 90474937
Ear pain 31.21 11.19 26 140174 57676 90430571
Ankyloglossia congenital 30.99 11.19 12 140188 210 90488037
Eosinophilic cystitis 30.89 11.19 9 140191 61 90488186
Platelet count decreased 30.86 11.19 336 139864 136633 90351614
Osteonecrosis of jaw 30.75 11.19 11 140189 39092 90449155
Hypotonia neonatal 30.75 11.19 22 140178 1408 90486839
Vertigo 30.66 11.19 199 140001 69612 90418635
CSF measles antibody positive 30.64 11.19 9 140191 63 90488184
Necrobiosis lipoidica diabeticorum 30.57 11.19 8 140192 34 90488213
Cerebral venous sinus thrombosis 30.52 11.19 27 140173 2349 90485898
Cardiac arrest neonatal 30.22 11.19 10 140190 108 90488139
Haemorrhage intracranial 30.00 11.19 70 140130 15092 90473155
Product use issue 29.98 11.19 346 139854 329573 90158674
Blepharospasm 29.97 11.19 25 140175 55420 90432827
Rubella antibody positive 29.82 11.19 9 140191 70 90488177
Headache 29.78 11.19 1064 139136 861682 89626565
Poverty of thought content 29.71 11.19 7 140193 17 90488230
Apraxia 29.65 11.19 26 140174 2236 90486011
Productive cough 29.43 11.19 46 140154 77017 90411230
Withdrawal syndrome 29.32 11.19 89 140111 22435 90465812
Manic symptom 29.27 11.19 9 140191 75 90488172
Neuroleptic malignant syndrome 29.11 11.19 69 140131 15027 90473220
Hypersomnia 28.89 11.19 86 140114 21445 90466802
Herpes zoster 28.65 11.19 65 140135 94579 90393668
Atrioventricular block 28.61 11.19 50 140150 8765 90479482
Prescribed underdose 28.44 11.19 45 140155 74974 90413273
Pregnancy on oral contraceptive 28.31 11.19 19 140181 1096 90487151
Myalgia 28.31 11.19 157 140043 174968 90313279
Oropharyngeal oedema 28.24 11.19 13 140187 355 90487892
Product residue present 28.18 11.19 34 140166 4257 90483990
Infantile apnoea 28.13 11.19 20 140180 1267 90486980
Drug eruption 28.12 11.19 119 140081 35288 90452959
Rhinorrhoea 28.10 11.19 59 140141 88257 90399990
Ultrasound ovary abnormal 28.00 11.19 9 140191 88 90488159
Psychomotor skills impaired 27.99 11.19 28 140172 2844 90485403
Walking aid user 27.90 11.19 10 140190 35496 90452751
Unmasking of previously unidentified disease 27.88 11.19 21 140179 1455 90486792
Osteochondrosis 27.87 11.19 23 140177 1820 90486427
Blood brain barrier defect 27.74 11.19 10 140190 142 90488105
Bile acid malabsorption 27.69 11.19 12 140188 283 90487964
Mucosal inflammation 27.63 11.19 168 140032 57457 90430790
Grey matter heterotopia 27.37 11.19 5 140195 0 90488247
Emotional disorder 27.26 11.19 67 140133 14930 90473317
Inappropriate antidiuretic hormone secretion 27.22 11.19 79 140121 19426 90468821
Poor personal hygiene 27.17 11.19 13 140187 388 90487859
Cytomegalovirus hepatitis 26.93 11.19 13 140187 396 90487851
Gestational diabetes 26.83 11.19 54 140146 10528 90477719
Live birth 26.76 11.19 51 140149 79056 90409191
Hallucination, olfactory 26.61 11.19 12 140188 312 90487935
Flushing 26.61 11.19 61 140139 88430 90399817
Rash morbilliform 26.58 11.19 32 140168 3997 90484250
Myocardial infarction 26.57 11.19 80 140120 105892 90382355
Herpes simplex encephalitis 26.51 11.19 13 140187 410 90487837
Opsoclonus myoclonus 26.48 11.19 10 140190 163 90488084
CSF protein increased 26.45 11.19 16 140184 770 90487477
Catastrophic reaction 26.34 11.19 7 140193 32 90488215
Ulcer 26.29 11.19 9 140191 32873 90455374
Product prescribing error 26.06 11.19 104 140096 30041 90458206
Psychotic behaviour 26.00 11.19 15 140185 661 90487586
Angiomyolipoma 25.96 11.19 11 140189 245 90488002
Cardio-respiratory arrest 25.92 11.19 177 140023 62963 90425284
Illness 25.88 11.19 55 140145 81914 90406333
Encephalomalacia 25.75 11.19 14 140186 549 90487698
Adverse event 25.75 11.19 94 140106 117324 90370923
Pregnancy on contraceptive 25.75 11.19 19 140181 1276 90486971
Diffuse cutaneous mastocytosis 25.66 11.19 7 140193 36 90488211
Balance disorder 25.61 11.19 246 139954 96834 90391413
Impulse-control disorder 25.58 11.19 17 140183 965 90487282
Coronary artery disease 25.53 11.19 10 140190 33613 90454634
Astrocytoma 25.28 11.19 8 140192 74 90488173
Ulcer haemorrhage 25.24 11.19 5 140195 26316 90461931
Procedural pain 25.20 11.19 10 140190 33350 90454897
Nervous system disorder 25.05 11.19 82 140118 21511 90466736
Sinus bradycardia 24.96 11.19 70 140130 16882 90471365
Slow speech 24.90 11.19 22 140178 1911 90486336
Hydrops foetalis 24.64 11.19 14 140186 599 90487648
Epidermolysis bullosa 24.60 11.19 10 140190 200 90488047
Drug level below therapeutic 24.33 11.19 37 140163 5777 90482470
Petechiae 24.17 11.19 66 140134 15675 90472572
Balamuthia infection 24.12 11.19 8 140192 87 90488160
Meningitis aseptic 24.07 11.19 40 140160 6733 90481514
Drowning 24.00 11.19 13 140187 506 90487741
Bradyarrhythmia 24.00 11.19 24 140176 2437 90485810
Coma blister 23.98 11.19 9 140191 144 90488103
Hypokalaemia 23.95 11.19 309 139891 130807 90357440
Acute myocardial infarction 23.94 11.19 12 140188 34878 90453369
Blood oestrogen increased 23.93 11.19 10 140190 215 90488032
Psychiatric symptom 23.92 11.19 41 140159 7077 90481170
Cerebral atrophy 23.72 11.19 36 140164 5610 90482637
Drug tolerance decreased 23.68 11.19 10 140190 32120 90456127
Lipids abnormal 23.61 11.19 11 140189 309 90487938
Mental impairment 23.60 11.19 68 140132 16652 90471595
Cellulitis 23.58 11.19 68 140132 91269 90396978
Metastases to meninges 23.56 11.19 29 140171 3706 90484541
Lymphocyte adoptive therapy 23.42 11.19 6 140194 23 90488224
Motor developmental delay 23.39 11.19 10 140190 228 90488019
Disorganised speech 23.38 11.19 21 140179 1864 90486383
Eosinophilic pneumonia 23.36 11.19 25 140175 2748 90485499
Mitochondrial encephalomyopathy 23.34 11.19 8 140192 97 90488150
Quadriparesis 23.29 11.19 24 140176 2525 90485722
Atrial septal defect 23.28 11.19 44 140156 8190 90480057
Hiccups 23.26 11.19 26 140174 3000 90485247
Therapy partial responder 23.19 11.19 81 140119 21962 90466285
Eye pruritus 23.11 11.19 8 140192 29019 90459228
Necrotising colitis 23.00 11.19 18 140182 1320 90486927
Bradypnoea 22.92 11.19 32 140168 4626 90483621
Impulsive behaviour 22.90 11.19 20 140180 1710 90486537
Craniotomy 22.88 11.19 11 140189 332 90487915
Psychological trauma 22.83 11.19 18 140182 1335 90486912
Sinus congestion 22.82 11.19 7 140193 27417 90460830
Rebound effect 22.74 11.19 47 140153 9337 90478910
Inappropriate affect 22.57 11.19 16 140184 1009 90487238
Acquired immunodeficiency syndrome 22.56 11.19 8 140192 108 90488139
Multiple sclerosis 22.45 11.19 94 140106 27746 90460501
Cerebral artery stenosis 22.42 11.19 13 140187 578 90487669
Condition aggravated 22.40 11.19 1131 139069 594414 89893833
Ventricular hypokinesia 22.36 11.19 34 140166 5307 90482940
Central nervous system infection 22.34 11.19 15 140185 866 90487381
Blood pressure fluctuation 22.28 11.19 29 140171 52384 90435863
Tachycardia 22.19 11.19 355 139845 157318 90330929
Prescribed overdose 22.17 11.19 77 140123 97548 90390699
Cleft lip 22.00 11.19 9 140191 183 90488064
Acidosis hyperchloraemic 21.96 11.19 15 140185 891 90487356
Morbid thoughts 21.96 11.19 14 140186 740 90487507
Hypogammaglobulinaemia 21.91 11.19 50 140150 10624 90477623
Intestinal atresia 21.89 11.19 4 140196 0 90488247
Pregnancy with implant contraceptive 21.81 11.19 28 140172 3733 90484514
Medical observation 21.77 11.19 9 140191 188 90488059
Limb reduction defect 21.69 11.19 13 140187 615 90487632
Lymphangioleiomyomatosis 21.69 11.19 10 140190 274 90487973
Drug dose titration not performed 21.66 11.19 14 140186 758 90487489
Immunodeficiency 21.56 11.19 21 140179 43213 90445034
Constipation 21.41 11.19 305 139895 280090 90208157
Vagal nerve stimulator implantation 21.36 11.19 6 140194 35 90488212
Device dislocation 21.34 11.19 11 140189 31471 90456776
Weight decreased 21.31 11.19 437 139763 379473 90108774
Pulmonary arterial hypertension 21.23 11.19 7 140193 26180 90462067
Ocular hyperaemia 21.20 11.19 13 140187 33785 90454462
Nosocomial infection 21.18 11.19 20 140180 1893 90486354
Sleep disorder 21.11 11.19 200 140000 197830 90290417
Syncope 21.10 11.19 305 139895 132358 90355889
Intrauterine infection 21.09 11.19 8 140192 132 90488115
Rectal haemorrhage 21.07 11.19 62 140138 82682 90405565
Respiratory tract congestion 21.07 11.19 8 140192 27402 90460845
Completed suicide 20.94 11.19 328 139872 144730 90343517
Cortical dysplasia 20.81 11.19 6 140194 39 90488208
Tubulointerstitial nephritis 20.77 11.19 86 140114 25257 90462990
Language disorder 20.75 11.19 23 140177 2629 90485618
Euthyroid sick syndrome 20.72 11.19 7 140193 81 90488166
Intrusive thoughts 20.67 11.19 11 140189 413 90487834
Acquired macroglossia 20.66 11.19 9 140191 215 90488032
Refusal of treatment by patient 20.54 11.19 34 140166 5704 90482543
Bladder sphincter atony 20.51 11.19 9 140191 219 90488028
Intensive care unit acquired weakness 20.48 11.19 15 140185 996 90487251
Patent ductus arteriosus 20.44 11.19 30 140170 4539 90483708
Hepatic function abnormal 20.35 11.19 132 140068 46156 90442091
Sedation 20.35 11.19 136 140064 48035 90440212
Asthenia 20.29 11.19 650 139550 533101 89955146
Cranial nerve disorder 20.27 11.19 13 140187 694 90487553
Diverticulitis 20.25 11.19 24 140176 45163 90443084
Brain injury 20.23 11.19 40 140160 7698 90480549
Lipids 20.21 11.19 5 140195 16 90488231
Nodule 20.16 11.19 8 140192 26678 90461569
Educational problem 20.15 11.19 12 140188 561 90487686
Paraesthesia oral 20.10 11.19 12 140188 31647 90456600
Interleukin level increased 20.02 11.19 13 140187 709 90487538
Dyspnoea exertional 20.02 11.19 52 140148 72236 90416011
Right aortic arch 19.99 11.19 9 140191 233 90488014
Chronic sinusitis 19.94 11.19 6 140194 23796 90464451
Necrotising enterocolitis neonatal 19.85 11.19 9 140191 237 90488010
Gastric pH increased 19.84 11.19 6 140194 47 90488200
Juvenile myoclonic epilepsy 19.76 11.19 5 140195 18 90488229
Palpitations 19.76 11.19 127 140073 136601 90351646
Glycosuria 19.76 11.19 17 140183 1425 90486822
Food interaction 19.59 11.19 16 140184 1248 90486999
Anaplastic astrocytoma 19.41 11.19 6 140194 51 90488196
Cerebral disorder 19.40 11.19 33 140167 5661 90482586
Asterixis 19.39 11.19 18 140182 1667 90486580
Basal cell carcinoma 19.38 11.19 14 140186 33375 90454872
Neonatal seizure 19.33 11.19 12 140188 605 90487642
Paternal exposure before pregnancy 19.31 11.19 7 140193 101 90488146
Vasogenic cerebral oedema 19.30 11.19 16 140184 1274 90486973
Thunderclap headache 19.23 11.19 10 140190 358 90487889
Catatonia 19.20 11.19 34 140166 6022 90482225
Ejection fraction decreased 19.14 11.19 86 140114 26167 90462080
Congenital spinal fusion 19.13 11.19 4 140196 4 90488243
Device expulsion 19.10 11.19 21 140179 40865 90447382
Psychiatric decompensation 19.04 11.19 19 140181 1924 90486323
Therapeutic product ineffective 19.00 11.19 21 140179 2393 90485854
Vomiting 18.90 11.19 1012 139188 787281 89700966
Blood creatine phosphokinase 18.89 11.19 8 140192 178 90488069
Burning sensation 18.86 11.19 44 140156 63408 90424839
Renal dysplasia 18.83 11.19 10 140190 374 90487873
Pulmonary valve stenosis congenital 18.81 11.19 8 140192 180 90488067
Rhesus incompatibility 18.71 11.19 7 140193 111 90488136
Postictal psychosis 18.71 11.19 7 140193 111 90488136
Product selection error 18.71 11.19 9 140191 272 90487975
Premature rupture of membranes 18.65 11.19 32 140168 5526 90482721
Systemic inflammatory response syndrome 18.65 11.19 35 140165 6481 90481766
Pulmonary hypertension 18.62 11.19 23 140177 42500 90445747
Depressive symptom 18.50 11.19 31 140169 5254 90482993
Irregular sleep phase 18.45 11.19 5 140195 25 90488222
Radiation necrosis 18.38 11.19 12 140188 661 90487586
Jaundice 18.34 11.19 99 140101 32418 90455829
Microcephaly 18.32 11.19 16 140184 1368 90486879
Mydriasis 18.31 11.19 58 140142 14954 90473293
Ear malformation 18.29 11.19 9 140191 286 90487961
Cephalhaematoma 18.24 11.19 4 140196 6 90488241
Urine amphetamine positive 18.20 11.19 6 140194 64 90488183
Atrioventricular block second degree 18.16 11.19 28 140172 4424 90483823
Placental disorder 18.13 11.19 17 140183 1594 90486653
Musculoskeletal discomfort 18.12 11.19 5 140195 20986 90467261
Hyporesponsive to stimuli 18.08 11.19 17 140183 1600 90486647
Drop attacks 18.04 11.19 12 140188 682 90487565
Hot flush 17.89 11.19 41 140159 59447 90428800
Gaze palsy 17.87 11.19 17 140183 1624 90486623
Blood creatine phosphokinase MB increased 17.85 11.19 15 140185 1217 90487030
Amylase increased 17.82 11.19 36 140164 7036 90481211
Brain neoplasm malignant 17.76 11.19 15 140185 1226 90487021
Cerebral cyst 17.73 11.19 9 140191 306 90487941
Thyroid atrophy 17.71 11.19 9 140191 307 90487940
Mixed anxiety and depressive disorder 17.70 11.19 10 140190 423 90487824
Severe myoclonic epilepsy of infancy 17.64 11.19 6 140194 71 90488176
Cerebral mass effect 17.59 11.19 14 140186 1052 90487195
Glioma 17.53 11.19 10 140190 431 90487816
Cerebral haematoma 17.53 11.19 27 140173 4262 90483985
Systolic dysfunction 17.53 11.19 18 140182 1886 90486361
Illusion 17.52 11.19 15 140185 1249 90486998
B-lymphocyte count decreased 17.50 11.19 16 140184 1453 90486794
Cyanosis neonatal 17.49 11.19 10 140190 433 90487814
Depression 17.49 11.19 598 139602 300003 90188244
Sinus arrest 17.47 11.19 19 140181 2127 90486120
Conversion disorder 17.47 11.19 19 140181 2127 90486120
Polydactyly 17.47 11.19 9 140191 316 90487931
Threatened labour 17.46 11.19 13 140187 885 90487362
Dysphagia 17.41 11.19 257 139943 112021 90376226
Congenital arterial malformation 17.31 11.19 9 140191 322 90487925
Oscillopsia 17.31 11.19 7 140193 138 90488109
Eastern Cooperative Oncology Group performance status worsened 17.26 11.19 18 140182 1921 90486326
Sudden infant death syndrome 17.24 11.19 9 140191 325 90487922
Product administered to patient of inappropriate age 17.24 11.19 28 140172 4625 90483622
Anotia 17.19 11.19 4 140196 9 90488238
Congenital neurological disorder 17.19 11.19 4 140196 9 90488238
Heart rate irregular 17.18 11.19 8 140192 24260 90463987
Oropharyngeal pain 17.15 11.19 106 140094 115081 90373166
Pyloric stenosis 17.14 11.19 10 140190 450 90487797
Cleft lip and palate 17.11 11.19 12 140188 744 90487503
Abortion threatened 17.08 11.19 11 140189 592 90487655
Injection site rash 17.06 11.19 8 140192 24165 90464082
Tooth infection 17.05 11.19 5 140195 20165 90468082
Lymphangioma 17.02 11.19 5 140195 35 90488212
Influenza 16.90 11.19 136 140064 139128 90349119
Heart rate 16.87 11.19 8 140192 234 90488013
CNS ventriculitis 16.84 11.19 8 140192 235 90488012
Staphylococcal scalded skin syndrome 16.73 11.19 7 140193 151 90488096
Sneezing 16.72 11.19 13 140187 29856 90458391
Arteriovenous malformation 16.72 11.19 16 140184 1539 90486708
Blood pressure diastolic abnormal 16.68 11.19 5 140195 19876 90468371
Hemiplegia 16.67 11.19 59 140141 16101 90472146
Mitochondrial cytopathy 16.62 11.19 8 140192 242 90488005
Clonus 16.60 11.19 31 140169 5719 90482528
Labelled drug-drug interaction medication error 16.58 11.19 55 140145 14527 90473720
Weight fluctuation 16.50 11.19 5 140195 19744 90468503
Abnormal product of conception 16.42 11.19 3 140197 0 90488247
Electrocardiogram delta waves abnormal 16.42 11.19 3 140197 0 90488247
Paroxysmal sympathetic hyperactivity 16.42 11.19 3 140197 0 90488247
Bronchiectasis 16.37 11.19 7 140193 22323 90465924
Anticonvulsant drug level abnormal 16.23 11.19 5 140195 42 90488205
Respiratory disorder 16.19 11.19 49 140151 64767 90423480
Bone pain 16.11 11.19 46 140154 61937 90426310
B-lymphocyte abnormalities 16.04 11.19 8 140192 262 90487985
Throat irritation 15.94 11.19 32 140168 48663 90439584
Frontal lobe epilepsy 15.90 11.19 4 140196 14 90488233
Theft 15.76 11.19 6 140194 100 90488147
Sinus disorder 15.76 11.19 18 140182 34429 90453818
Heart rate increased 15.74 11.19 106 140094 112796 90375451
Spinal osteoarthritis 15.73 11.19 5 140195 19143 90469104
Blood lactic acid increased 15.73 11.19 39 140161 8739 90479508
Potentiating drug interaction 15.69 11.19 30 140170 5632 90482615
Vascular graft infection 15.64 11.19 5 140195 48 90488199
Tooth disorder 15.62 11.19 15 140185 31075 90457172
Hiatus hernia 15.57 11.19 10 140190 25351 90462896
Amniorrhexis 15.54 11.19 5 140195 49 90488198
Hepatic failure 15.50 11.19 110 140090 39618 90448629
Parasitic encephalitis 15.45 11.19 5 140195 50 90488197
Injection site warmth 15.45 11.19 4 140196 17511 90470736
Teratoma 15.38 11.19 7 140193 186 90488061
Logorrhoea 15.34 11.19 20 140180 2707 90485540
Spinal stenosis 15.33 11.19 4 140196 17420 90470827
Urinary tract stoma complication 15.28 11.19 5 140195 52 90488195
Primary mediastinal large B-cell lymphoma 15.28 11.19 5 140195 52 90488195
Foetal malformation 15.24 11.19 8 140192 292 90487955
Confusional state 15.23 11.19 737 139463 385468 90102779
Tendonitis 15.20 11.19 7 140193 21365 90466882
Respiratory syncytial virus bronchiolitis 15.17 11.19 9 140191 418 90487829
Drug-device interaction 15.09 11.19 6 140194 113 90488134
Drug effective for unapproved indication 15.06 11.19 36 140164 7882 90480365
Cleft palate 15.03 11.19 14 140186 1302 90486945
Injection site haemorrhage 15.02 11.19 13 140187 28305 90459942
Haemolytic anaemia 15.02 11.19 46 140154 11651 90476596
Nail dystrophy 15.01 11.19 14 140186 1304 90486943
Injection site bruising 14.97 11.19 37 140163 52270 90435977
Disability 14.92 11.19 25 140175 40720 90447527
Hostility 14.91 11.19 18 140182 2255 90485992
Placental infarction 14.90 11.19 8 140192 306 90487941
Placenta praevia 14.88 11.19 13 140187 1112 90487135
Liver function test increased 14.87 11.19 74 140126 84781 90403466
Brain abscess 14.86 11.19 20 140180 2792 90485455
Localised infection 14.86 11.19 18 140182 33544 90454703
Neonatal disorder 14.82 11.19 10 140190 582 90487665
Choreoathetosis 14.82 11.19 10 140190 582 90487665
Dysgraphia 14.79 11.19 23 140177 3660 90484587
Motor dysfunction 14.78 11.19 64 140136 19166 90469081
Blindness cortical 14.78 11.19 10 140190 585 90487662
Intensive care unit delirium 14.71 11.19 5 140195 59 90488188
Bronchiolitis 14.68 11.19 22 140178 3390 90484857
Lactation disorder 14.66 11.19 9 140191 445 90487802
Congenital muscle absence 14.59 11.19 4 140196 21 90488226
Coma acidotic 14.58 11.19 6 140194 124 90488123
Pancreatic atrophy 14.55 11.19 8 140192 321 90487926
Postmature baby 14.53 11.19 6 140194 125 90488122
Drug exposure before pregnancy 14.49 11.19 12 140188 954 90487293
Proctitis 14.42 11.19 3 140197 15256 90472991
Dementia 14.39 11.19 74 140126 23787 90464460
Cerebrosclerosis 14.34 11.19 3 140197 3 90488244
Eye irritation 14.23 11.19 19 140181 33959 90454288
Dry skin 14.20 11.19 79 140121 87994 90400253
Self-medication 14.20 11.19 21 140179 3199 90485048
Cerebellar atrophy 14.19 11.19 11 140189 796 90487451
Myositis 14.16 11.19 10 140190 24118 90464129
Drug tolerance 14.16 11.19 5 140195 17911 90470336
Reversible cerebral vasoconstriction syndrome 14.15 11.19 24 140176 4106 90484141
Intracranial hypotension 14.15 11.19 8 140192 339 90487908
Bromoderma 14.15 11.19 4 140196 24 90488223
Epilepsy surgery 14.15 11.19 4 140196 24 90488223
Illogical thinking 14.13 11.19 5 140195 67 90488180
Hypoosmolar state 14.13 11.19 7 140193 226 90488021
Therapeutic response shortened 14.07 11.19 9 140191 22870 90465377
Pneumonia 14.01 11.19 826 139374 637233 89851014
Joint dislocation 14 11.19 30 140170 44552 90443695
Erysipelas 13.94 11.19 38 140162 9014 90479233
Foreign body in gastrointestinal tract 13.93 11.19 5 140195 70 90488177
Cerebral haemorrhage neonatal 13.90 11.19 6 140194 140 90488107
Breast cancer 13.90 11.19 40 140160 53721 90434526
Talipes 13.89 11.19 15 140185 1665 90486582
Hepatitis 13.89 11.19 169 140031 70570 90417677
QRS axis abnormal 13.81 11.19 13 140187 1225 90487022
Attention-seeking behaviour 13.81 11.19 5 140195 72 90488175
Coma hepatic 13.76 11.19 10 140190 656 90487591
Echopraxia 13.74 11.19 5 140195 73 90488174
Chronic obstructive pulmonary disease 13.74 11.19 63 140137 73766 90414481
General symptom 13.62 11.19 3 140197 14665 90473582
Astrocytoma malignant 13.62 11.19 4 140196 28 90488219
Perinatal depression 13.58 11.19 11 140189 848 90487399
Incorrect route of product administration 13.58 11.19 37 140163 50589 90437658
Brain tumour operation 13.56 11.19 5 140195 76 90488171
Performance status decreased 13.53 11.19 24 140176 4256 90483991
Papilloedema 13.47 11.19 25 140175 4590 90483657
Respiratory rate decreased 13.46 11.19 23 140177 3960 90484287
Acute disseminated encephalomyelitis 13.40 11.19 7 140193 253 90487994
Intestinal ischaemia 13.39 11.19 37 140163 8846 90479401
Drug abuse 13.36 11.19 190 140010 82157 90406090
Rotator cuff syndrome 13.36 11.19 4 140196 15915 90472332
Resuscitation 13.31 11.19 13 140187 1283 90486964
Treatment failure 13.31 11.19 363 139837 303565 90184682
Brain death 13.30 11.19 23 140177 3998 90484249
Dyscalculia 13.27 11.19 6 140194 157 90488090
Substance use disorder 13.26 11.19 16 140184 2004 90486243
Device malfunction 13.25 11.19 8 140192 20969 90467278
Shunt malfunction 13.21 11.19 5 140195 82 90488165
Abulia 13.20 11.19 10 140190 699 90487548
Lichen myxoedematosus 13.15 11.19 4 140196 32 90488215
High-pitched crying 13.15 11.19 4 140196 32 90488215
Radiation skin injury 13.14 11.19 12 140188 1088 90487159
Encephalitis protozoal 13.13 11.19 3 140197 6 90488241
Glycogen storage disorder 13.13 11.19 3 140197 6 90488241
Abdominal distension 13.03 11.19 134 140066 130467 90357780
Bone marrow failure 13.03 11.19 90 140110 32131 90456116
Hypocalcaemia 13.03 11.19 111 140089 42257 90445990
Visual field defect 13.01 11.19 32 140168 7134 90481113
Laryngeal stenosis 12.95 11.19 13 140187 1326 90486921
Feeling drunk 12.93 11.19 25 140175 4733 90483514
Tuberous sclerosis complex 12.89 11.19 5 140195 88 90488159
Respiratory depression 12.88 11.19 53 140147 15522 90472725
Throat tightness 12.85 11.19 16 140184 29468 90458779
Diabetes insipidus 12.82 11.19 20 140180 3192 90485055
Accessory auricle 12.82 11.19 3 140197 7 90488240
Agoraphobia 12.82 11.19 9 140191 559 90487688
Amnestic disorder 12.81 11.19 8 140192 408 90487839
Liver disorder 12.69 11.19 123 140077 121146 90367101
Electrocardiogram repolarisation abnormality 12.65 11.19 13 140187 1363 90486884
Haemoptysis 12.61 11.19 20 140180 33300 90454947
Akathisia 12.61 11.19 42 140158 11117 90477130
Carnitine deficiency 12.57 11.19 6 140194 178 90488069
Postpartum haemorrhage 12.57 11.19 17 140183 2384 90485863
Hallucinations, mixed 12.55 11.19 28 140172 5861 90482386
Mucocutaneous rash 12.55 11.19 4 140196 38 90488209
Amylase abnormal 12.45 11.19 4 140196 39 90488208
Cyst 12.45 11.19 5 140195 16556 90471691
Primary mediastinal large B-cell lymphoma recurrent 12.44 11.19 5 140195 97 90488150
Multiple congenital abnormalities 12.42 11.19 9 140191 588 90487659
Adverse drug reaction 12.37 11.19 118 140082 116583 90371664
Schizophreniform disorder 12.34 11.19 5 140195 99 90488148
Anxiety disorder 12.34 11.19 25 140175 4897 90483350
Ventriculo-peritoneal shunt 12.27 11.19 3 140197 9 90488238
Sialoadenitis 12.27 11.19 16 140184 2166 90486081
Haemangioma 12.22 11.19 19 140181 3023 90485224
Prolonged labour 12.18 11.19 9 140191 606 90487641
Infantile haemangioma 12.16 11.19 5 140195 103 90488144
Cardiac disorder 12.16 11.19 46 140154 56826 90431421
Pulmonary mass 12.14 11.19 16 140184 28756 90459491
Electrocardiogram ST segment elevation 12.03 11.19 22 140178 3994 90484253
Foetal distress syndrome 12.01 11.19 14 140186 1691 90486556
Shock 12.01 11.19 81 140119 28697 90459550
Bradykinesia 11.99 11.19 30 140170 6758 90481489
Diabetes mellitus inadequate control 11.98 11.19 7 140193 18677 90469570
Hirsutism 11.97 11.19 14 140186 1696 90486551
Product dispensing error 11.97 11.19 44 140156 12229 90476018
Device issue 11.89 11.19 17 140183 29520 90458727
Poverty of speech 11.88 11.19 7 140193 321 90487926
Oral candidiasis 11.86 11.19 23 140177 35432 90452815
Basal ganglia stroke 11.86 11.19 5 140195 110 90488137
Amniocentesis abnormal 11.86 11.19 5 140195 110 90488137
Congenital central nervous system anomaly 11.85 11.19 8 140192 466 90487781
Meningomyelocele 11.83 11.19 9 140191 633 90487614
Hepatitis viral 11.73 11.19 9 140191 641 90487606
Diabetes mellitus 11.70 11.19 56 140144 64819 90423428
Nail infection 11.67 11.19 17 140183 2555 90485692
Intestinal obstruction 11.65 11.19 25 140175 37106 90451141
Intracranial mass 11.64 11.19 12 140188 1263 90486984
Glutamate dehydrogenase increased 11.63 11.19 4 140196 49 90488198
Threatened uterine rupture 11.61 11.19 3 140197 12 90488235
Biopsy brain 11.61 11.19 3 140197 12 90488235
Dysgeusia 11.57 11.19 42 140158 52518 90435729
Fluid intake reduced 11.51 11.19 22 140178 4130 90484117
Aortic disorder 11.50 11.19 10 140190 850 90487397
Clumsiness 11.49 11.19 17 140183 2590 90485657
Autoimmune encephalopathy 11.49 11.19 4 140196 51 90488196
Hypersensitivity vasculitis 11.48 11.19 22 140178 4137 90484110
Gelastic seizure 11.42 11.19 3 140197 13 90488234
Basilar migraine 11.42 11.19 4 140196 52 90488195
Paraparesis 11.32 11.19 18 140182 2920 90485327
Therapeutic response changed 11.32 11.19 12 140188 1305 90486942
Musculoskeletal chest pain 11.32 11.19 12 140188 23738 90464509
Product quality issue 11.29 11.19 74 140126 79251 90408996
Drug dispensed to wrong patient 11.29 11.19 7 140193 352 90487895
Drooling 11.29 11.19 23 140177 4523 90483724
Premature separation of placenta 11.28 11.19 16 140184 2346 90485901
Tenderness 11.28 11.19 15 140185 26853 90461394
Negative thoughts 11.26 11.19 11 140189 1086 90487161
Electrolyte imbalance 11.24 11.19 69 140131 23676 90464571
Poisoning 11.21 11.19 50 140150 15167 90473080
Incorrect dose administered 11.21 11.19 178 140022 78752 90409495
Injection site urticaria 11.20 11.19 7 140193 18004 90470243

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 4781.03 10.96 3392 117138 117169 42383636
Status epilepticus 2030.38 10.96 955 119575 14623 42486182
Epilepsy 1216.47 10.96 815 119715 25356 42475449
Multiple-drug resistance 1168.24 10.96 517 120013 6805 42494000
Generalised tonic-clonic seizure 1167.66 10.96 797 119733 25582 42475223
Drug ineffective 823.90 10.96 3731 116799 626466 41874339
Partial seizures 793.19 10.96 369 120161 5490 42495315
Aggression 576.58 10.96 667 119863 43496 42457309
Rhabdomyolysis 513.30 10.96 846 119684 77173 42423632
Foetal exposure during pregnancy 439.60 10.96 603 119927 46708 42454097
Drug reaction with eosinophilia and systemic symptoms 407.17 10.96 547 119983 41528 42459277
Product substitution issue 404.32 10.96 300 120230 10990 42489815
Dyspnoea 394.98 10.96 403 120127 442218 42058587
Somnolence 315.56 10.96 996 119534 140109 42360696
Behaviour disorder 306.79 10.96 211 120319 6843 42493962
Irritability 287.94 10.96 376 120154 27752 42473053
Maternal exposure during pregnancy 278.45 10.96 198 120332 6780 42494025
Encephalopathy 260.57 10.96 440 120090 40893 42459912
Cytokine release syndrome 259.76 10.96 458 120072 44069 42456736
Focal dyscognitive seizures 258.03 10.96 111 120419 1356 42499449
Cognitive disorder 253.92 10.96 392 120138 33780 42467025
Petit mal epilepsy 253.86 10.96 147 120383 3503 42497302
Psychogenic seizure 244.24 10.96 79 120451 396 42500409
Ataxia 233.18 10.96 257 120273 15868 42484937
Immune effector cell-associated neurotoxicity syndrome 211.29 10.96 191 120339 9270 42491535
Drug withdrawal convulsions 208.59 10.96 93 120437 1245 42499560
Arthralgia 204.83 10.96 168 120362 205070 42295735
Drug resistance 204.56 10.96 356 120174 33892 42466913
Agitation 196.12 10.96 508 120022 63806 42436999
Myoclonic epilepsy 194.68 10.96 95 120435 1579 42499226
Aura 183.70 10.96 62 120468 363 42500442
Myocardial infarction 183.35 10.96 61 120469 123948 42376857
Hyperammonaemia 181.98 10.96 162 120368 7704 42493101
Electroencephalogram abnormal 178.09 10.96 109 120421 2883 42497922
Diarrhoea 176.04 10.96 690 119840 460159 42040646
Tonic convulsion 174.70 10.96 88 120442 1571 42499234
Sudden unexplained death in epilepsy 174.15 10.96 63 120467 466 42500339
Change in seizure presentation 171.65 10.96 55 120475 266 42500539
Aphasia 171.55 10.96 271 120259 23812 42476993
Postictal psychosis 156.68 10.96 47 120483 174 42500631
Glioblastoma 153.70 10.96 77 120453 1358 42499447
Abnormal behaviour 151.53 10.96 270 120260 26181 42474624
Myoclonus 148.65 10.96 211 120319 16854 42483951
Pain 143.82 10.96 298 120232 244550 42256255
Drug ineffective for unapproved indication 139.00 10.96 363 120167 45800 42455005
Drug interaction 134.69 10.96 1247 119283 265752 42235053
Anticonvulsant drug level above therapeutic 132.18 10.96 56 120474 657 42500148
Developmental delay 130.90 10.96 92 120438 3090 42497715
No adverse event 129.10 10.96 318 120212 38703 42462102
Partial seizures with secondary generalisation 126.53 10.96 47 120483 378 42500427
Anticonvulsant drug level decreased 126.13 10.96 64 120466 1161 42499644
Pain in extremity 126.08 10.96 144 120386 150460 42350345
Anticonvulsant drug level increased 124.53 10.96 70 120460 1573 42499232
Maternal drugs affecting foetus 124.13 10.96 96 120434 3743 42497062
Pneumonia aspiration 122.40 10.96 365 120165 49713 42451092
Stevens-Johnson syndrome 120.18 10.96 221 120309 21957 42478848
Delirium 120.13 10.96 374 120156 52145 42448660
Seizure cluster 118.32 10.96 41 120489 263 42500542
Cardiac failure congestive 118.20 10.96 47 120483 85555 42415250
Infantile spasms 117.97 10.96 40 120490 238 42500567
Hepatocellular injury 115.98 10.96 226 120304 23452 42477353
Confusional state 115.24 10.96 840 119690 166757 42334048
Chest pain 115.07 10.96 135 120395 139395 42361410
Anticonvulsant drug level below therapeutic 112.30 10.96 50 120480 667 42500138
Back pain 109.75 10.96 144 120386 141632 42359173
Anger 107.58 10.96 157 120373 12861 42487944
Toxic epidermal necrolysis 105.99 10.96 234 120296 26516 42474289
Off label use 105.55 10.96 2451 118079 635884 41864921
Malaise 104.73 10.96 283 120247 211873 42288932
Atrial septal defect 103.88 10.96 120 120410 7799 42493006
Rheumatoid arthritis 102.47 10.96 4 120526 42436 42458369
Nausea 101.83 10.96 681 119849 396118 42104687
Brain malformation 100.85 10.96 32 120498 149 42500656
Hemiparesis 99.03 10.96 177 120353 17199 42483606
Coronary artery disease 95.60 10.96 18 120512 53702 42447103
Thrombocytopenia 95.44 10.96 888 119642 189391 42311414
Wrong patient received product 93.40 10.96 79 120451 3504 42497301
Abdominal pain 91.06 10.96 258 120272 190213 42310592
Atrial fibrillation 90.49 10.96 160 120370 139433 42361372
Premature baby 90 10.96 201 120329 22952 42477853
Cough 89.82 10.96 235 120295 177868 42322937
Simple partial seizures 86.39 10.96 36 120494 404 42500401
Brain oedema 85.08 10.96 160 120370 16167 42484638
Joint swelling 85.03 10.96 43 120487 67979 42432826
Exposure via breast milk 84.61 10.96 64 120466 2413 42498392
Encephalitis autoimmune 84.09 10.96 51 120479 1326 42499479
Neuropathy peripheral 81.34 10.96 101 120429 101752 42399053
Toxic optic neuropathy 80.70 10.96 45 120485 995 42499810
COVID-19 79.66 10.96 128 120402 115820 42384985
Chronic obstructive pulmonary disease 78.74 10.96 40 120490 63074 42437731
Chest discomfort 78.35 10.96 41 120489 63575 42437230
Psychiatric symptom 78.19 10.96 77 120453 4164 42496641
Rash maculo-papular 77.51 10.96 258 120272 37245 42463560
Febrile convulsion 75.80 10.96 38 120492 671 42500134
Pruritus 75.38 10.96 277 120253 188494 42312311
Stupor 75.05 10.96 66 120464 3087 42497718
Low birth weight baby 73.62 10.96 114 120416 9841 42490964
Injection site pain 73.05 10.96 36 120494 57762 42443043
Cryptorchism 72.86 10.96 54 120476 1973 42498832
Anaemia 71.77 10.96 481 120049 279797 42221008
Prostate cancer 71.31 10.96 19 120511 44624 42456181
Small for dates baby 71.13 10.96 81 120449 5182 42495623
Abdominal discomfort 70.81 10.96 65 120465 75190 42425615
Anticoagulation drug level abnormal 70.33 10.96 24 120506 146 42500659
Death 70.18 10.96 926 119604 470259 42030546
Neurotoxicity 70.16 10.96 185 120345 23466 42477339
Nystagmus 69.49 10.96 81 120449 5315 42495490
Arthritis 68.93 10.96 17 120513 42048 42458757
Psychotic disorder 68.62 10.96 210 120320 28998 42471807
Asthma 68.51 10.96 46 120484 62268 42438537
Hyperammonaemic encephalopathy 68.20 10.96 59 120471 2699 42498106
Pneumonia 67.93 10.96 816 119714 421333 42079472
Glioblastoma multiforme 65.29 10.96 37 120493 845 42499960
Atonic seizures 65.12 10.96 29 120501 387 42500418
Ventricular septal defect 65.12 10.96 71 120459 4328 42496477
Posterior reversible encephalopathy syndrome 64.77 10.96 124 120406 12697 42488108
Mood altered 64.73 10.96 112 120418 10606 42490199
Psychomotor hyperactivity 62.92 10.96 112 120418 10846 42489959
Oedema peripheral 62.31 10.96 188 120342 135888 42364917
Brain operation 61.78 10.96 30 120500 493 42500312
Suicidal ideation 61.73 10.96 285 120245 47876 42452929
Eosinophilia 61.59 10.96 219 120311 32680 42468125
Blood creatine phosphokinase increased 61.19 10.96 285 120245 48053 42452752
Dysmorphism 60.75 10.96 60 120470 3256 42497549
Overdose 60.30 10.96 506 120024 104758 42396047
Cerebral cyst 60.03 10.96 25 120505 280 42500525
Mental status changes 59.84 10.96 257 120273 41858 42458947
Gastrointestinal haemorrhage 59.77 10.96 116 120414 97610 42403195
Febrile neutropenia 59.67 10.96 296 120234 185407 42315398
Depressed level of consciousness 59.38 10.96 281 120249 47689 42453116
Neurological decompensation 59.33 10.96 63 120467 3726 42497079
Cardiogenic shock 59.18 10.96 14 120516 35626 42465179
Paradoxical drug reaction 59.15 10.96 70 120460 4668 42496137
Affective disorder 58.37 10.96 78 120452 5882 42494923
Myalgia 57.93 10.96 115 120415 95965 42404840
Acute myocardial infarction 57.43 10.96 48 120482 58117 42442688
Brain neoplasm 57.07 10.96 60 120470 3508 42497297
Hypotonia neonatal 56.65 10.96 41 120489 1443 42499362
Suicide attempt 56.30 10.96 269 120261 45831 42454974
Psoriasis 56.00 10.96 34 120496 48570 42452235
Treatment noncompliance 55.94 10.96 233 120297 37439 42463366
Accidental death 55.03 10.96 55 120475 3028 42497777
Clonic convulsion 54.97 10.96 33 120497 842 42499963
Postictal paralysis 54.94 10.96 25 120505 352 42500453
Drug level decreased 54.77 10.96 100 120430 9877 42490928
Sedation 54.61 10.96 200 120330 30275 42470530
Cardiac failure 54.58 10.96 140 120390 106716 42394089
Cholestasis 54.13 10.96 210 120320 32669 42468136
Coordination abnormal 53.77 10.96 88 120442 7962 42492843
Altered state of consciousness 53.26 10.96 193 120337 29066 42471739
Productive cough 52.85 10.96 41 120489 51526 42449279
Dyspnoea exertional 52.51 10.96 39 120491 50109 42450696
Psoriatic arthropathy 52.38 10.96 5 120525 24962 42475843
Temporal lobe epilepsy 52.36 10.96 21 120509 212 42500593
Hyperhidrosis 52.31 10.96 111 120419 90401 42410404
Stress 52.25 10.96 30 120500 44182 42456623
Ascites 52.09 10.96 50 120480 56628 42444177
Toxic encephalopathy 51.94 10.96 80 120450 6873 42493932
Thrombosis 51.53 10.96 71 120459 68440 42432365
Abdominal pain upper 51.43 10.96 97 120433 82512 42418293
Acute psychosis 51.18 10.96 45 120485 2104 42498701
Pleural effusion 50.63 10.96 126 120404 97040 42403765
Impulsive behaviour 50.33 10.96 47 120483 2378 42498427
Vanishing bile duct syndrome 50.31 10.96 42 120488 1829 42498976
Personality change 50.22 10.96 71 120459 5648 42495157
Blood pressure increased 50.18 10.96 136 120394 101792 42399013
Memory impairment 50.14 10.96 277 120253 49945 42450860
Cholestatic liver injury 49.98 10.96 57 120473 3652 42497153
Tubulointerstitial nephritis 49.91 10.96 199 120331 31349 42469456
Pulmonary fibrosis 49.52 10.96 8 120522 26673 42474132
Infantile apnoea 49.43 10.96 34 120496 1102 42499703
Urethral atresia 49.12 10.96 13 120517 26 42500779
Dyskinesia 48.36 10.96 170 120360 25220 42475585
Haemoptysis 48.22 10.96 36 120494 46131 42454674
Postictal state 47.89 10.96 32 120498 988 42499817
Melaena 47.66 10.96 25 120505 38721 42462084
Gaze palsy 47.60 10.96 41 120489 1864 42498941
Chills 47.45 10.96 124 120406 93942 42406863
Epileptic encephalopathy 47.44 10.96 21 120509 276 42500529
Pulmonary embolism 47.38 10.96 176 120354 119436 42381369
Selective eating disorder 46.19 10.96 39 120491 1725 42499080
Haemoglobin decreased 46.14 10.96 205 120325 132266 42368539
Disorientation 45.64 10.96 214 120316 36175 42464630
Angina pectoris 45.49 10.96 18 120512 32878 42467927
Vagal nerve stimulator implantation 45.30 10.96 15 120515 82 42500723
Hypertension 44.72 10.96 283 120247 166921 42333884
Hyponatraemia 44.65 10.96 461 120069 101001 42399804
Hamartoma 44.46 10.96 13 120517 43 42500762
Gait disturbance 44.43 10.96 448 120082 97552 42403253
Constipation 44.28 10.96 273 120257 162018 42338787
Aplastic anaemia 44.24 10.96 104 120426 12280 42488525
Fluid retention 44.22 10.96 17 120513 31602 42469203
Hydrocephalus 44.10 10.96 69 120461 6009 42494796
Cardiac disorder 44.00 10.96 44 120486 48888 42451917
Talipes 43.85 10.96 42 120488 2194 42498611
Hypoventilation neonatal 43.84 10.96 9 120521 0 42500805
Dysarthria 43.44 10.96 225 120305 39582 42461223
Parkinsonism 43.29 10.96 94 120436 10529 42490276
Speech disorder developmental 43.08 10.96 42 120488 2243 42498562
Propofol infusion syndrome 42.99 10.96 32 120498 1177 42499628
Nasopharyngitis 42.92 10.96 110 120420 83886 42416919
Gout 42.84 10.96 13 120517 28042 42472763
Blood creatinine increased 42.82 10.96 163 120367 109840 42390965
Polydactyly 42.40 10.96 32 120498 1202 42499603
Sinusitis 41.98 10.96 43 120487 47249 42453556
Asthenia 41.96 10.96 551 119979 280242 42220563
Hypospadias 41.74 10.96 51 120479 3516 42497289
Diabetes mellitus 41.55 10.96 66 120464 60021 42440784
Intellectual disability 41.25 10.96 38 120492 1889 42498916
Foetal megacystis 40.55 10.96 13 120517 63 42500742
Neonatal pneumonia 40.45 10.96 15 120515 120 42500685
Diabetes insipidus 40.11 10.96 51 120479 3662 42497143
Eye movement disorder 39.93 10.96 59 120471 4886 42495919
Hyperkalaemia 39.86 10.96 107 120423 80351 42420454
Arthropathy 39.62 10.96 17 120513 29580 42471225
Neonatal respiratory distress syndrome 39.59 10.96 56 120474 4457 42496348
Hallucination, visual 39.40 10.96 140 120390 20880 42479925
Intensive care unit acquired weakness 39.24 10.96 31 120499 1247 42499558
Plasma cell myeloma 39.21 10.96 46 120484 47532 42453273
Infusion related reaction 39.09 10.96 70 120460 60736 42440069
Wheezing 39.00 10.96 59 120471 54722 42446083
Drop attacks 38.98 10.96 23 120507 568 42500237
Lung disorder 38.78 10.96 47 120483 47876 42452929
Cerebral atrophy 38.73 10.96 59 120471 5020 42495785
Glomerulonephritis minimal lesion 38.31 10.96 24 120506 662 42500143
Peripheral swelling 37.62 10.96 130 120400 90140 42410665
Staring 37.40 10.96 33 120497 1550 42499255
Vesicoureteric reflux 37.37 10.96 16 120514 193 42500612
Maternal exposure before pregnancy 37.17 10.96 28 120502 1049 42499756
Mood swings 37.00 10.96 79 120451 8747 42492058
Disturbance in attention 36.98 10.96 175 120355 29691 42471114
Condition aggravated 36.96 10.96 982 119548 259772 42241033
Bladder cancer 36.89 10.96 3 120527 17044 42483761
Plasmapheresis 36.58 10.96 20 120510 425 42500380
Appendicitis 36.47 10.96 7 120523 20606 42480199
Developmental regression 36.40 10.96 11 120519 42 42500763
Psychomotor skills impaired 36.27 10.96 58 120472 5146 42495659
Maternal exposure during breast feeding 35.91 10.96 32 120498 1523 42499282
Speech disorder 35.60 10.96 170 120360 28951 42471854
Tuberous sclerosis complex 35.31 10.96 12 120518 72 42500733
Hypotonia 35.28 10.96 81 120449 9418 42491387
Gliosis 34.80 10.96 16 120514 231 42500574
Muscle twitching 34.79 10.96 92 120438 11688 42489117
Delusion 34.66 10.96 106 120424 14628 42486177
Anaphylactic reaction 34.50 10.96 42 120488 42701 42458104
Frequent bowel movements 34.39 10.96 9 120521 21398 42479407
Abdominal distension 34.34 10.96 97 120433 71638 42429167
Hypothermia 34.21 10.96 95 120435 12420 42488385
Autonomic nervous system imbalance 33.98 10.96 43 120487 3073 42497732
Convulsive threshold lowered 33.85 10.96 20 120510 495 42500310
Haemophagocytic lymphohistiocytosis 33.84 10.96 121 120409 18101 42482704
Lower respiratory tract infection 33.78 10.96 40 120490 41166 42459639
Affect lability 33.74 10.96 49 120481 3995 42496810
Cerebellar atrophy 33.73 10.96 23 120507 735 42500070
Hypertransaminasaemia 33.52 10.96 78 120452 9149 42491656
Myelosuppression 33.47 10.96 39 120491 40422 42460383
Congenital hypoplasia of depressor angularis oris muscle 33.45 10.96 8 120522 8 42500797
Irregular sleep phase 33.43 10.96 13 120517 120 42500685
Non-24-hour sleep-wake disorder 33.37 10.96 9 120521 20 42500785
Neonatal infection 33.37 10.96 19 120511 438 42500367
Necrosis ischaemic 33.33 10.96 18 120512 373 42500432
Weight decreased 33.29 10.96 402 120128 207546 42293259
Synovitis 32.97 10.96 3 120527 15564 42485241
Influenza 32.87 10.96 80 120450 62095 42438710
Meningitis aseptic 32.68 10.96 51 120479 4431 42496374
Organic brain syndrome 32.61 10.96 17 120513 327 42500478
Attention deficit hyperactivity disorder 32.49 10.96 42 120488 3066 42497739
Coma blister 32.22 10.96 11 120519 67 42500738
Excessive eye blinking 32.20 10.96 21 120509 622 42500183
Bronchiectasis 32.13 10.96 6 120524 18013 42482792
Myasthenia gravis 31.90 10.96 4 120526 16133 42484672
Muscle spasms 31.89 10.96 130 120400 85914 42414891
Arteriosclerosis coronary artery 31.68 10.96 7 120523 18670 42482135
Hallucination 31.62 10.96 274 120256 57233 42443572
Syndactyly 31.49 10.96 24 120506 915 42499890
Drug withdrawal syndrome neonatal 31.48 10.96 50 120480 4411 42496394
Interstitial lung disease 31.35 10.96 115 120415 78347 42422458
Depressive symptom 31.15 10.96 46 120484 3807 42496998
Acute coronary syndrome 31.12 10.96 3 120527 14862 42485943
Thinking abnormal 31.06 10.96 65 120465 7096 42493709
Blood pressure fluctuation 30.74 10.96 19 120511 26889 42473916
International normalised ratio increased 30.47 10.96 56 120474 48112 42452693
Coma 30.41 10.96 257 120273 53297 42447508
Haematochezia 30.25 10.96 76 120454 58360 42442445
Failure to suspend medication 30.12 10.96 17 120513 385 42500420
Nicotinic acid deficiency 30.02 10.96 12 120518 120 42500685
Inappropriate antidiuretic hormone secretion 30.00 10.96 109 120421 16432 42484373
Metastases to central nervous system 29.70 10.96 80 120450 10275 42490530
Encephalitis 29.60 10.96 74 120456 9084 42491721
Hallucination, auditory 29.59 10.96 101 120429 14763 42486042
Swelling 29.50 10.96 70 120460 54815 42445990
Prostatic specific antigen increased 29.41 10.96 6 120524 16919 42483886
Congenital nail disorder 28.88 10.96 9 120521 39 42500766
Balance disorder 28.85 10.96 232 120298 47413 42453392
Rash morbilliform 28.55 10.96 46 120484 4107 42496698
Product use issue 28.38 10.96 337 120193 76414 42424391
Nasal congestion 28.31 10.96 25 120505 29476 42471329
Hypernatraemia 28.26 10.96 77 120453 9955 42490850
Cataract congenital 28.06 10.96 11 120519 104 42500701
Bronchitis 28.00 10.96 57 120473 47144 42453661
Epileptic psychosis 27.95 10.96 8 120522 24 42500781
Palpitations 27.93 10.96 64 120466 50733 42450072
Neonatal hypotension 27.83 10.96 13 120517 195 42500610
Electrocardiogram QRS complex prolonged 27.80 10.96 55 120475 5768 42495037
Serratia sepsis 27.79 10.96 12 120518 148 42500657
Epidermal necrosis 27.68 10.96 20 120510 702 42500103
Paranoia 27.65 10.96 95 120435 13931 42486874
Atrioventricular septal defect 27.59 10.96 14 120516 254 42500551
Injection site swelling 27.53 10.96 7 120523 16966 42483839
Hippocampal sclerosis 27.50 10.96 12 120518 152 42500653
Patent ductus arteriosus 27.39 10.96 41 120489 3435 42497370
Apathy 27.25 10.96 68 120462 8338 42492467
Substance-induced psychotic disorder 27.06 10.96 37 120493 2852 42497953
Nasal septum disorder 26.91 10.96 9 120521 51 42500754
Foetal growth restriction 26.56 10.96 51 120479 5232 42495573
Suicidal behaviour 26.53 10.96 27 120503 1519 42499286
Cerebellar ataxia 26.46 10.96 24 120506 1169 42499636
Dry mouth 26.45 10.96 45 120485 39834 42460971
Postmature baby 26.45 10.96 7 120523 14 42500791
Acidosis hyperchloraemic 26.45 10.96 19 120511 661 42500144
Single umbilical artery 26.32 10.96 13 120517 222 42500583
Magnetic resonance imaging head abnormal 26.23 10.96 27 120503 1540 42499265
Biopsy skin 26.17 10.96 6 120524 4 42500801
Anencephaly 26.04 10.96 11 120519 128 42500677
Nervous system disorder 26.03 10.96 107 120423 17088 42483717
Ammonia increased 25.96 10.96 47 120483 4612 42496193
Cerebral haemorrhage 25.95 10.96 194 120336 38772 42462033
Dry skin 25.70 10.96 62 120468 48276 42452529
Musculoskeletal stiffness 25.56 10.96 81 120449 57684 42443121
Squamous cell carcinoma of skin 25.54 10.96 3 120527 12723 42488082
Blepharospasm 25.52 10.96 25 120505 1343 42499462
Bradyphrenia 25.48 10.96 50 120480 5212 42495593
Agnosia 25.37 10.96 10 120520 96 42500709
Colitis ulcerative 25.34 10.96 22 120508 26153 42474652
Rectal haemorrhage 25.30 10.96 65 120465 49541 42451264
Oculogyric crisis 25.28 10.96 28 120502 1737 42499068
Neonatal respiratory depression 25.27 10.96 16 120514 450 42500355
Citrobacter test positive 25.24 10.96 7 120523 18 42500787
Astrocytoma, low grade 25.19 10.96 10 120520 98 42500707
Poor feeding infant 24.95 10.96 20 120510 822 42499983
Acoustic stimulation tests abnormal 24.83 10.96 9 120521 67 42500738
Limb reduction defect 24.77 10.96 14 120516 318 42500487
Contraindicated product administered 24.76 10.96 21 120509 25251 42475554
Arteriosclerosis 24.61 10.96 10 120520 17979 42482826
Product administration error 24.57 10.96 110 120420 18233 42482572
Sepsis 24.57 10.96 406 120124 198928 42301877
Urge incontinence 24.53 10.96 17 120513 558 42500247
Flushing 24.36 10.96 42 120488 36986 42463819
Neuropsychiatric symptoms 24.29 10.96 19 120511 753 42500052
Burnout syndrome 24.29 10.96 11 120519 153 42500652
Swollen tongue 24.24 10.96 15 120515 21216 42479589
Eastern Cooperative Oncology Group performance status worsened 24.15 10.96 24 120506 1312 42499493
Prescribed overdose 24.14 10.96 86 120444 12841 42487964
Anomaly of external ear congenital 24.09 10.96 10 120520 111 42500694
Glioma 24.06 10.96 16 120514 490 42500315
Wrong drug 24.04 10.96 11 120519 157 42500648
Administration site discomfort 23.97 10.96 8 120522 45 42500760
Cerebral amyloid angiopathy 23.91 10.96 13 120517 273 42500532
Mucosal ulceration 23.88 10.96 24 120506 1330 42499475
Persecutory delusion 23.85 10.96 39 120491 3525 42497280
Localised infection 23.82 10.96 14 120516 20359 42480446
Anaphylactic shock 23.71 10.96 19 120511 23498 42477307
Idiopathic generalised epilepsy 23.68 10.96 8 120522 47 42500758
Dyspepsia 23.64 10.96 51 120479 41301 42459504
Mixed liver injury 23.50 10.96 44 120486 4430 42496375
Lichenoid keratosis 23.49 10.96 41 120489 3909 42496896
Diverticulitis 23.46 10.96 18 120512 22755 42478050
Injection site erythema 23.44 10.96 14 120516 20181 42480624
Blood glucose increased 23.33 10.96 118 120412 73581 42427224
Mental disorder 23.32 10.96 107 120423 17922 42482883
Therapeutic response shortened 23.15 10.96 5 120525 13549 42487256
End stage renal disease 22.99 10.96 9 120521 16549 42484256
Cleft palate 22.91 10.96 17 120513 622 42500183
Cellulitis 22.84 10.96 93 120437 61492 42439313
Respiratory disorder neonatal 22.78 10.96 28 120502 1942 42498863
Intentional product use issue 22.74 10.96 115 120415 71718 42429087
Nodule 22.72 10.96 4 120526 12530 42488275
Blood phosphorus increased 22.70 10.96 4 120526 12521 42488284
Laboratory test abnormal 22.63 10.96 19 120511 22959 42477846
Hot flush 22.61 10.96 18 120512 22333 42478472
Obstructive airways disorder 22.56 10.96 22 120508 24737 42476068
Injection site bruising 22.44 10.96 3 120527 11522 42489283
Full blood count abnormal 22.42 10.96 31 120499 29845 42470960
Feeling hot 22.41 10.96 20 120510 23462 42477343
Fall 22.32 10.96 842 119688 233678 42267127
Language disorder 22.14 10.96 31 120499 2444 42498361
Paraplegia 21.96 10.96 36 120494 3261 42497544
Fatigue 21.93 10.96 1008 119522 434633 42066172
Unresponsive to stimuli 21.86 10.96 158 120372 31245 42469560
Autism spectrum disorder 21.79 10.96 34 120496 2954 42497851
Tinnitus 21.74 10.96 30 120500 28908 42471897
Dysmetria 21.73 10.96 18 120512 775 42500030
Psychomotor retardation 21.55 10.96 42 120488 4357 42496448
Inappropriate schedule of product administration 21.38 10.96 171 120359 95731 42405074
Limbic encephalitis 21.37 10.96 14 120516 418 42500387
Intestinal intraepithelial lymphocytes increased 21.27 10.96 11 120519 208 42500597
Toxic skin eruption 21.23 10.96 86 120444 13644 42487161
Personality disorder 21.22 10.96 21 120509 1142 42499663
Altered pitch perception 21.21 10.96 6 120524 17 42500788
Penoscrotal fusion 21.21 10.96 6 120524 17 42500788
Perseveration 21.21 10.96 9 120521 106 42500699
Ehlers-Danlos syndrome 21.18 10.96 7 120523 38 42500767
COVID-19 pneumonia 21.12 10.96 18 120512 21595 42479210
Systemic inflammatory response syndrome 21.10 10.96 57 120473 7333 42493472
Chronic kidney disease 21.07 10.96 66 120464 47175 42453630
Crying 21.02 10.96 52 120478 6342 42494463
Osteonecrosis of jaw 21.01 10.96 14 120516 19035 42481770
Blood pressure systolic increased 21.01 10.96 29 120501 27939 42472866
Blood glucose decreased 20.98 10.96 7 120523 14212 42486593
Urticaria 20.97 10.96 123 120407 73913 42426892
Purple glove syndrome 20.95 10.96 8 120522 70 42500735
Bradykinesia 20.90 10.96 47 120483 5389 42495416
Central nervous system lesion 20.78 10.96 59 120471 7811 42492994
Metabolic encephalopathy 20.78 10.96 46 120484 5219 42495586
Pulmonary oedema 20.68 10.96 79 120451 53193 42447612
Developmental coordination disorder 20.58 10.96 11 120519 223 42500582
Poor sucking reflex 20.58 10.96 13 120517 364 42500441
Bronchopulmonary aspergillosis 20.48 10.96 15 120515 19414 42481391
Herpes simplex encephalitis 20.36 10.96 13 120517 371 42500434
Hypometabolism 20.34 10.96 10 120520 169 42500636
Misleading laboratory test result 20.26 10.96 6 120524 21 42500784
Drug eruption 20.24 10.96 123 120407 22952 42477853
Metastatic malignant melanoma 20.16 10.96 29 120501 2344 42498461
Renal injury 20.04 10.96 5 120525 12275 42488530
Angina unstable 20.01 10.96 4 120526 11444 42489361
Paternal exposure before pregnancy 19.93 10.96 7 120523 47 42500758
Eye pruritus 19.92 10.96 4 120526 11408 42489397
Hyperphosphataemia 19.90 10.96 6 120524 12998 42487807
Bacterial infection 19.86 10.96 30 120500 27849 42472956
Coma neonatal 19.84 10.96 6 120524 23 42500782
Hepatic cytolysis 19.81 10.96 137 120393 26707 42474098
Type 2 diabetes mellitus 19.81 10.96 14 120516 18457 42482348
Intracranial tumour haemorrhage 19.76 10.96 13 120517 391 42500414
Cardiopulmonary failure 19.72 10.96 42 120488 4641 42496164
Psychomotor disadaptation syndrome 19.67 10.96 8 120522 84 42500721
Hypersensitivity 19.57 10.96 122 120408 72248 42428557
Drug level increased 19.51 10.96 134 120396 26066 42474739
Post-traumatic epilepsy 19.48 10.96 4 120526 0 42500805
Terminal insomnia 19.44 10.96 18 120512 901 42499904
Tooth disorder 19.31 10.96 5 120525 11974 42488831
Hostility 19.31 10.96 17 120513 796 42500009
Subacute sclerosing panencephalitis 19.26 10.96 6 120524 26 42500779
Oropharyngeal pain 19.24 10.96 59 120471 42451 42458354
Stillbirth 19.20 10.96 10 120520 192 42500613
Respiratory symptom 19.17 10.96 4 120526 11102 42489703
Rash scarlatiniform 19.15 10.96 9 120521 137 42500668
Pulmonary valve stenosis congenital 19.03 10.96 9 120521 139 42500666
Herpes zoster 19.02 10.96 52 120478 38825 42461980
Acute hepatic failure 18.97 10.96 97 120433 16976 42483829
Drug abuse 18.93 10.96 197 120333 104574 42396231
Systemic infection 18.90 10.96 44 120486 5161 42495644
Frontal lobe epilepsy 18.90 10.96 6 120524 28 42500777
Coronary artery occlusion 18.90 10.96 4 120526 10993 42489812
Poisoning deliberate 18.89 10.96 3 120527 10131 42490674
Posture abnormal 18.82 10.96 29 120501 2492 42498313
Skin ulcer 18.78 10.96 27 120503 25574 42475231
Iris adhesions 18.77 10.96 11 120519 268 42500537
Burning sensation 18.77 10.96 19 120511 20994 42479811
Physical assault 18.76 10.96 19 120511 1063 42499742
Brain abscess 18.71 10.96 39 120491 4245 42496560
Bradycardia neonatal 18.65 10.96 21 120509 1327 42499478
Loss of personal independence in daily activities 18.62 10.96 75 120455 49741 42451064
Cryptitis 18.34 10.96 11 120519 280 42500525
Feeling drunk 18.32 10.96 27 120503 2231 42498574
Drug-induced liver injury 18.31 10.96 177 120353 38096 42462709
Asterixis 18.28 10.96 21 120509 1356 42499449
Neurodevelopmental disorder 18.28 10.96 13 120517 445 42500360
Slow response to stimuli 18.25 10.96 18 120512 975 42499830
Ulcer 18.25 10.96 12 120518 16429 42484376
Subdural haematoma 18.22 10.96 120 120410 23018 42477787
Retinitis viral 18.21 10.96 9 120521 154 42500651
Treatment failure 18.13 10.96 263 120267 62361 42438444
Discomfort 18.10 10.96 27 120503 25192 42475613
Presyncope 18.06 10.96 22 120508 22365 42478440
Pathogen resistance 18.04 10.96 5 120525 11445 42489360
Glycosylated haemoglobin increased 17.98 10.96 7 120523 12917 42487888
Neuralgia 17.89 10.96 28 120502 25619 42475186
White blood cell count decreased 17.80 10.96 213 120317 110183 42390622
Heart rate decreased 17.77 10.96 49 120481 36483 42464322
Catatonia 17.69 10.96 48 120482 6191 42494614
Muscle contracture 17.58 10.96 21 120509 1414 42499391
Hypoaesthesia 17.55 10.96 124 120406 71339 42429466
Deja vu 17.47 10.96 5 120525 15 42500790
Microvillous inclusion disease 17.47 10.96 10 120520 233 42500572
Cerebellar syndrome 17.45 10.96 30 120500 2825 42497980
Cardiac septal hypertrophy 17.44 10.96 12 120518 389 42500416
Congenital hydrocephalus 17.41 10.96 9 120521 170 42500635
Large for dates baby 17.36 10.96 17 120513 913 42499892
Renal impairment 17.27 10.96 214 120316 110014 42390791
Holmes tremor 17.25 10.96 4 120526 3 42500802
Epilepsy surgery 17.25 10.96 4 120526 3 42500802
Drug level below therapeutic 17.22 10.96 49 120481 6496 42494309
Renal disorder 17.18 10.96 35 120495 28945 42471860
Apallic syndrome 17.16 10.96 11 120519 316 42500489
Leukopenia 17.16 10.96 302 120228 74444 42426361
Vasculitis 17.16 10.96 16 120514 18378 42482427
Metabolic acidosis 17.14 10.96 223 120307 51635 42449170
Hyponatraemic seizure 17.08 10.96 9 120521 177 42500628
Low set ears 17.05 10.96 13 120517 496 42500309
Necrotising enterocolitis neonatal 17.04 10.96 11 120519 320 42500485
Haemorrhoids 17.00 10.96 14 120516 17083 42483722
Potter's syndrome 17.00 10.96 5 120525 17 42500788
Restlessness 16.93 10.96 141 120389 29108 42471697
Karyotype analysis abnormal 16.92 10.96 7 120523 77 42500728
Benign cardiac neoplasm 16.87 10.96 6 120524 42 42500763
Gastritis 16.84 10.96 26 120504 23921 42476884
Caesarean section 16.82 10.96 25 120505 2081 42498724
Full blood count decreased 16.81 10.96 20 120510 20540 42480265
Pneumonitis 16.75 10.96 61 120469 41657 42459148
Cholelithiasis 16.75 10.96 25 120505 23321 42477484
Tonic clonic movements 16.74 10.96 20 120510 1347 42499458
Blood urea increased 16.70 10.96 43 120487 32750 42468055
Product taste abnormal 16.63 10.96 19 120511 1220 42499585
Vitamin B6 decreased 16.57 10.96 5 120525 19 42500786
Drug dependence 16.53 10.96 36 120494 29058 42471747
Blood pressure decreased 16.47 10.96 97 120433 58235 42442570
Haemofiltration 16.44 10.96 8 120522 132 42500673
Blood uric acid increased 16.39 10.96 12 120518 15535 42485270
Rash 16.39 10.96 629 119901 276325 42224480
Congenital anomaly 16.38 10.96 21 120509 1520 42499285
Haematuria 16.38 10.96 96 120434 57703 42443102
Neck pain 16.35 10.96 38 120492 29976 42470829
Myositis 16.30 10.96 11 120519 14855 42485950
Impaired quality of life 16.21 10.96 10 120520 14167 42486638
Head banging 16.18 10.96 9 120521 198 42500607
Pelvic neoplasm 16.18 10.96 6 120524 48 42500757
Oral mucosal exfoliation 16.10 10.96 9 120521 200 42500605
Bladder hypertrophy 16.08 10.96 15 120515 758 42500047
Caudal regression syndrome 15.97 10.96 6 120524 50 42500755
Myocardial ischaemia 15.93 10.96 16 120514 17746 42483059
Meningeal disorder 15.93 10.96 11 120519 359 42500446
Executive dysfunction 15.89 10.96 10 120520 278 42500527
Amnesia 15.89 10.96 136 120394 28301 42472504
Lymphopenia 15.88 10.96 110 120420 21453 42479352
Therapeutic product effect decreased 15.88 10.96 57 120473 39093 42461712
Neonatal tachypnoea 15.85 10.96 11 120519 362 42500443
Rhinitis 15.84 10.96 7 120523 11970 42488835
Eyelid myoclonus 15.84 10.96 4 120526 6 42500799
Brain tumour operation 15.84 10.96 4 120526 6 42500799
Osteonecrosis 15.77 10.96 13 120517 15852 42484953
Night sweats 15.72 10.96 20 120510 19949 42480856
Impaired healing 15.71 10.96 15 120515 17038 42483767
Cataract 15.68 10.96 40 120490 30564 42470241
Initial insomnia 15.67 10.96 35 120495 3995 42496810
Bone pain 15.64 10.96 27 120503 23765 42477040
Drug withdrawal headache 15.63 10.96 5 120525 24 42500781
Orthostatic hypotension 15.63 10.96 40 120490 30530 42470275
SJS-TEN overlap 15.63 10.96 14 120516 671 42500134
Gynaecomastia 15.61 10.96 8 120522 12559 42488246
Hydrocele 15.60 10.96 27 120503 2556 42498249
Infection 15.58 10.96 223 120307 111845 42388960
Alcohol use disorder 15.56 10.96 6 120524 54 42500751
Retinogram abnormal 15.53 10.96 8 120522 150 42500655
Aplasia 15.51 10.96 39 120491 4804 42496001
Cytomegalovirus viraemia 15.50 10.96 5 120525 10372 42490433
Conjunctival irritation 15.48 10.96 7 120523 97 42500708
Gastrooesophageal reflux disease 15.46 10.96 70 120460 44953 42455852
Barbiturates positive 15.46 10.96 4 120526 7 42500798
Near drowning 15.46 10.96 4 120526 7 42500798
Epistaxis 15.43 10.96 118 120412 66708 42434097
Clonus 15.32 10.96 32 120498 3488 42497317
Probiotic therapy 15.29 10.96 8 120522 155 42500650
Anal spasm 15.29 10.96 8 120522 155 42500650
Anaplastic astrocytoma 15.29 10.96 7 120523 100 42500705
Device leakage 15.28 10.96 5 120525 10280 42490525
Pancreatic carcinoma 15.26 10.96 4 120526 9502 42491303
Exposure during pregnancy 15.22 10.96 56 120474 8492 42492313
Contusion 15.19 10.96 64 120466 41921 42458884
Squamous cell carcinoma 15.06 10.96 9 120521 12973 42487832
Diabetic ketoacidosis 15.05 10.96 25 120505 22342 42478463
Bicuspid aortic valve 15.05 10.96 10 120520 306 42500499
Therapy non-responder 15.02 10.96 223 120307 53136 42447669
Abscess 15.02 10.96 11 120519 14237 42486568
Dysphagia 15.01 10.96 289 120241 72430 42428375
Cross sensitivity reaction 15.01 10.96 21 120509 1654 42499151
Encephalitis viral 14.97 10.96 20 120510 1508 42499297
CSF white blood cell count increased 14.92 10.96 6 120524 61 42500744
Product administered to patient of inappropriate age 14.89 10.96 38 120492 4723 42496082
Gallbladder polyp 14.89 10.96 12 120518 497 42500308
Metastases to bone 14.88 10.96 12 120518 14797 42486008
Acute myeloid leukaemia 14.86 10.96 25 120505 22231 42478574
Bronchospasm 14.86 10.96 9 120521 12876 42487929
Tumour lysis syndrome 14.82 10.96 25 120505 22206 42478599
Diabetes mellitus inadequate control 14.82 10.96 13 120517 15377 42485428
Large intestine polyp 14.69 10.96 4 120526 9261 42491544
Gastric ulcer 14.68 10.96 18 120512 18244 42482561
Nocturia 14.62 10.96 8 120522 12104 42488701
Serratia infection 14.62 10.96 18 120512 1251 42499554
Infant sedation 14.61 10.96 3 120527 0 42500805
Gallbladder agenesis 14.61 10.96 3 120527 0 42500805
Brain lobectomy 14.61 10.96 3 120527 0 42500805
Ejection fraction decreased 14.58 10.96 25 120505 22062 42478743
Unevaluable event 14.53 10.96 49 120481 34239 42466566
Prominent epicanthal folds 14.51 10.96 8 120522 173 42500632
Red blood cell sedimentation rate increased 14.44 10.96 5 120525 9919 42490886
Autoimmune thyroiditis 14.43 10.96 20 120510 1562 42499243
Infant irritability 14.42 10.96 6 120524 67 42500738
Dysphemia 14.37 10.96 22 120508 1880 42498925
Pain in jaw 14.27 10.96 12 120518 14490 42486315
Haematuria traumatic 14.25 10.96 10 120520 335 42500470
Superinfection 14.24 10.96 28 120502 2923 42497882
Hepatic cirrhosis 14.23 10.96 21 120509 19681 42481124
Pulmonary mass 14.19 10.96 15 120515 16250 42484555
Large granular lymphocytosis 14.18 10.96 9 120521 254 42500551
Chemotherapeutic drug level above therapeutic 14.18 10.96 5 120525 34 42500771
Gastric haemorrhage 14.13 10.96 6 120524 10509 42490296
Renal cancer 14.12 10.96 3 120527 8221 42492584
Haemorrhage intracranial 14.05 10.96 90 120440 17102 42483703
Gastrointestinal disorder 14.03 10.96 76 120454 46577 42454228
Emphysema 14.02 10.96 8 120522 11827 42488978
Monorchidism 13.97 10.96 4 120526 12 42500793
Intentional self-injury 13.95 10.96 82 120448 15120 42485685
Oligodendroglioma 13.94 10.96 5 120525 36 42500769
Oesophageal carcinoma 13.91 10.96 5 120525 9691 42491114
Myelodysplastic syndrome 13.89 10.96 27 120503 22718 42478087
Palmar-plantar erythrodysaesthesia syndrome 13.86 10.96 23 120507 20559 42480246
Congenital hydronephrosis 13.82 10.96 14 120516 783 42500022
Blood pressure diastolic decreased 13.82 10.96 6 120524 10369 42490436
Tenderness 13.77 10.96 4 120526 8879 42491926
Wound closure 13.75 10.96 6 120524 76 42500729
Thrombotic microangiopathy 13.73 10.96 80 120450 14702 42486103
Foetal cardiac disorder 13.73 10.96 4 120526 13 42500792
Niemann-Pick disease 13.73 10.96 4 120526 13 42500792
Product lot number issue 13.70 10.96 5 120525 38 42500767
Automatism 13.70 10.96 7 120523 129 42500676
Throat tightness 13.69 10.96 5 120525 9594 42491211
Paresis 13.68 10.96 25 120505 2471 42498334
Sinus node dysfunction 13.62 10.96 37 120493 4775 42496030
Brain neoplasm malignant 13.60 10.96 15 120515 926 42499879
Gross motor delay 13.60 10.96 10 120520 361 42500444
Micturition frequency decreased 13.57 10.96 10 120520 362 42500443
Intestinal obstruction 13.53 10.96 36 120494 27122 42473683
Pneumothorax 13.48 10.96 29 120501 23514 42477291
Craniocerebral injury 13.48 10.96 32 120498 3802 42497003
Pruritus allergic 13.48 10.96 10 120520 366 42500439
Dysgraphia 13.45 10.96 25 120505 2503 42498302
Musculoskeletal discomfort 13.41 10.96 5 120525 9471 42491334
Syncope 13.40 10.96 199 120331 99207 42401598
Apraxia 13.39 10.96 19 120511 1516 42499289
Hypothalamo-pituitary disorder 13.32 10.96 16 120514 1084 42499721
Lower gastrointestinal haemorrhage 13.25 10.96 7 120523 10801 42490004
Erythema 13.25 10.96 222 120308 108571 42392234
Incoherent 13.24 10.96 36 120494 4649 42496156
Pulmonary toxicity 13.23 10.96 4 120526 8651 42492154
Lethargy 13.21 10.96 196 120334 46694 42454111
Plagiocephaly 13.14 10.96 12 120518 590 42500215
Cytotoxic oedema 13.12 10.96 8 120522 210 42500595
Post-anoxic myoclonus 13.09 10.96 4 120526 16 42500789
Dysgeusia 13.07 10.96 51 120479 34138 42466667
Creutzfeldt-Jakob disease 13.07 10.96 5 120525 44 42500761
Astrocytoma 13.06 10.96 8 120522 212 42500593
Deep vein thrombosis 12.97 10.96 147 120383 76810 42423995
Craniofacial deformity 12.97 10.96 6 120524 88 42500717
Intentional overdose 12.94 10.96 211 120319 51245 42449560
Head injury 12.88 10.96 101 120429 20481 42480324
Congenital megaureter 12.88 10.96 7 120523 147 42500658
Madarosis 12.87 10.96 11 120519 495 42500310
Flatulence 12.79 10.96 33 120497 25119 42475686
Dry eye 12.76 10.96 15 120515 15491 42485314
Amnestic disorder 12.76 10.96 9 120521 304 42500501
Hyperlipidaemia 12.74 10.96 26 120504 21490 42479315
Musculoskeletal chest pain 12.68 10.96 8 120522 11196 42489609
Endotracheal intubation 12.67 10.96 31 120499 3754 42497051
Obsessive-compulsive symptom 12.66 10.96 8 120522 224 42500581
Blood bilirubin increased 12.61 10.96 69 120461 42183 42458622
Urinary tract malformation 12.54 10.96 3 120527 3 42500802
Pyruvate kinase deficiency anaemia 12.54 10.96 3 120527 3 42500802
CSWS syndrome 12.54 10.96 3 120527 3 42500802
Antimitochondrial antibody 12.54 10.96 3 120527 3 42500802
Ganglioglioma 12.54 10.96 3 120527 3 42500802
Pulmonary thrombosis 12.51 10.96 4 120526 8344 42492461
Use of accessory respiratory muscles 12.50 10.96 11 120519 515 42500290
Food refusal 12.43 10.96 9 120521 317 42500488
Tracheitis 12.39 10.96 15 120515 1024 42499781
Device malfunction 12.38 10.96 10 120520 12317 42488488
Upper gastrointestinal haemorrhage 12.37 10.96 44 120486 30255 42470550
Joint stiffness 12.37 10.96 10 120520 12312 42488493
Coronary artery stenosis 12.32 10.96 7 120523 10372 42490433
Suspiciousness 12.31 10.96 10 120520 419 42500386
Glomerular filtration rate decreased 12.23 10.96 17 120513 16334 42484471
Peritumoural oedema 12.21 10.96 4 120526 21 42500784
Troponin increased 12.19 10.96 22 120508 19040 42481765
White blood cell count increased 12.19 10.96 76 120454 45011 42455794
Foetal anticonvulsant syndrome 12.19 10.96 16 120514 1186 42499619
Intentional product misuse 12.17 10.96 114 120416 61786 42439019
Vitamin B6 deficiency 12.16 10.96 9 120521 328 42500477
Circadian rhythm sleep disorder 12.14 10.96 11 120519 535 42500270
Gastrointestinal malformation 12.12 10.96 6 120524 103 42500702
Cardiac failure chronic 12.10 10.96 6 120524 9595 42491210
Traumatic lumbar puncture 12.08 10.96 3 120527 4 42500801
Upper airway obstruction 12.08 10.96 13 120517 781 42500024
Product dispensing issue 11.97 10.96 8 120522 247 42500558
Renal tubular acidosis 11.97 10.96 25 120505 2725 42498080
Lennox-Gastaut syndrome 11.97 10.96 6 120524 106 42500699
Cystitis haemorrhagic 11.93 10.96 3 120527 7326 42493479
Hypoxic-ischaemic encephalopathy 11.84 10.96 37 120493 5165 42495640
Sinus disorder 11.81 10.96 4 120526 8046 42492759
Periventricular haemorrhage neonatal 11.77 10.96 4 120526 24 42500781
Dystonia 11.74 10.96 69 120461 12721 42488084
Stomatitis haemorrhagic 11.72 10.96 6 120524 111 42500694
Hyperuricaemia 11.71 10.96 6 120524 9418 42491387
Cataract subcapsular 11.69 10.96 11 120519 562 42500243
Cortical dysplasia 11.69 10.96 3 120527 5 42500800
Bradypnoea 11.66 10.96 33 120497 4360 42496445
Accidental exposure to product by child 11.66 10.96 18 120512 1549 42499256
Abdominal compartment syndrome 11.66 10.96 15 120515 1090 42499715
Severe myoclonic epilepsy of infancy 11.63 10.96 4 120526 25 42500780
Athetosis 11.63 10.96 5 120525 61 42500744
Hyperfibrinogenaemia 11.62 10.96 6 120524 113 42500692
Apgar score low 11.62 10.96 14 120516 951 42499854
Contraindicated product prescribed 11.62 10.96 12 120518 687 42500118
Choreoathetosis 11.61 10.96 15 120515 1094 42499711
Gastric disorder 11.56 10.96 10 120520 11912 42488893
Agitation neonatal 11.48 10.96 17 120513 1411 42499394
Faeces discoloured 11.46 10.96 19 120511 16995 42483810
Tremor 11.46 10.96 357 120173 96572 42404233
Neoplasm malignant 11.44 10.96 30 120500 22713 42478092
Throat irritation 11.40 10.96 12 120518 13024 42487781
Arachnoid cyst 11.37 10.96 8 120522 269 42500536
Hyperacusis 11.37 10.96 14 120516 973 42499832
Apoptosis 11.37 10.96 11 120519 582 42500223
Drug monitoring procedure not performed 11.36 10.96 10 120520 468 42500337
Injection site mass 11.36 10.96 5 120525 8570 42492235
Uveitis 11.34 10.96 6 120524 9252 42491553
Transient epileptic amnesia 11.33 10.96 3 120527 6 42500799
CSF glucose increased 11.33 10.96 3 120527 6 42500799
Assisted delivery 11.33 10.96 3 120527 6 42500799
Decreased appetite 11.33 10.96 439 120091 192698 42308107
Blood potassium increased 11.32 10.96 22 120508 18514 42482291
Cerebral disorder 11.32 10.96 26 120504 3024 42497781
Syringe issue 11.31 10.96 5 120525 8551 42492254
Onychophagia 11.28 10.96 5 120525 66 42500739
Infective pulmonary exacerbation of cystic fibrosis 11.27 10.96 4 120526 7814 42492991
Wrong product administered 11.27 10.96 41 120489 6185 42494620
CSF white blood cell count decreased 11.25 10.96 4 120526 28 42500777
Benign prostatic hyperplasia 11.19 10.96 27 120503 21025 42479780
Gingival pain 11.18 10.96 5 120525 8489 42492316
Tricuspid valve incompetence 11.18 10.96 9 120521 11104 42489701
Meningitis 11.15 10.96 39 120491 5770 42495035
Retrognathia 11.14 10.96 8 120522 278 42500527
Pulmonary congestion 11.13 10.96 17 120513 15713 42485092
Injection site reaction 11.12 10.96 17 120513 15704 42485101
Blood calcium increased 11.09 10.96 5 120525 8449 42492356
Asthenospermia 11.08 10.96 5 120525 69 42500736
Mental disability 11.08 10.96 5 120525 69 42500736
Proteinuria 11.05 10.96 31 120499 22952 42477853
Lymphogranuloma venereum 11.02 10.96 3 120527 7 42500798
School refusal 11.01 10.96 4 120526 30 42500775
Tachycardia foetal 11.00 10.96 9 120521 381 42500424
Platelet count decreased 10.98 10.96 303 120227 138278 42362527

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 8890.99 10.69 5458 209935 215727 110158179
Status epilepticus 4397.35 10.69 1815 213578 29756 110344150
Multiple-drug resistance 2642.35 10.69 988 214405 12247 110361659
Generalised tonic-clonic seizure 2441.68 10.69 1448 213945 53232 110320674
Epilepsy 1558.99 10.69 1401 213992 98808 110275098
Drug ineffective 1525.23 10.69 6405 208988 1514135 108859771
Partial seizures 1476.66 10.69 622 214771 10727 110363179
Aggression 1413.24 10.69 1062 214331 58148 110315758
Drug reaction with eosinophilia and systemic symptoms 1152.54 10.69 1084 214309 81011 110292895
Rhabdomyolysis 979.47 10.69 1190 214203 119211 110254695
Somnolence 779.39 10.69 1761 213632 295688 110078218
Petit mal epilepsy 777.68 10.69 351 215042 7196 110366710
Irritability 734.25 10.69 664 214729 47145 110326761
Drug interaction 672.39 10.69 2321 213072 497862 109876044
Psychogenic seizure 666.46 10.69 228 215165 2136 110371770
Arthralgia 643.44 10.69 360 215033 779272 109594634
Focal dyscognitive seizures 606.45 10.69 242 215151 3607 110370299
Cytokine release syndrome 604.45 10.69 715 214678 69591 110304315
Behaviour disorder 589.25 10.69 314 215079 9333 110364573
Product substitution issue 586.63 10.69 430 214963 22631 110351275
Drug resistance 586.34 10.69 633 214760 55741 110318165
Agitation 556.23 10.69 877 214516 112174 110261732
Encephalopathy 551.07 10.69 733 214660 80322 110293584
Dyspnoea 536.75 10.69 831 214562 1106041 109267865
Joint swelling 525.25 10.69 111 215282 442734 109931172
Pain 520.56 10.69 659 214734 954296 109419610
Rheumatoid arthritis 518.09 10.69 14 215379 299599 110074307
Ataxia 509.77 10.69 442 214951 29666 110344240
Synovitis 506.14 10.69 5 215388 274087 110099819
Arthropathy 474.04 10.69 20 215373 287502 110086404
Drug ineffective for unapproved indication 455.84 10.69 761 214632 102077 110271829
Immune effector cell-associated neurotoxicity syndrome 436.78 10.69 302 215091 14480 110359426
Thrombocytopenia 435.46 10.69 1581 213812 347304 110026602
Myoclonic epilepsy 433.75 10.69 172 215221 2519 110371387
Abdominal discomfort 432.97 10.69 116 215277 393742 109980164
No adverse event 430.28 10.69 620 214773 73219 110300687
Anticonvulsant drug level decreased 417.23 10.69 157 215236 1979 110371927
Infusion related reaction 406.43 10.69 119 215274 381043 109992863
Abnormal behaviour 405.29 10.69 438 214955 38601 110335305
Anticonvulsant drug level increased 393.07 10.69 163 215230 2695 110371211
Paradoxical drug reaction 391.48 10.69 242 215151 9575 110364331
Myoclonus 390.40 10.69 397 214996 32601 110341305
Pemphigus 386.85 10.69 6 215387 214564 110159342
Cognitive disorder 384.36 10.69 645 214748 86866 110287040
Change in seizure presentation 372.28 10.69 114 215279 720 110373186
Sudden unexplained death in epilepsy 369.51 10.69 113 215280 710 110373196
Hyperammonaemia 358.19 10.69 260 215133 13472 110360434
Swelling 353.91 10.69 121 215272 350920 110022986
Glossodynia 351.32 10.69 20 215373 221984 110151922
Drug withdrawal convulsions 341.30 10.69 141 215252 2308 110371598
Pericarditis 334.07 10.69 24 215369 219090 110154816
Sinusitis 332.43 10.69 84 215309 296604 110077302
Contraindicated product administered 332.14 10.69 45 215348 248222 110125684
Psoriatic arthropathy 329.98 10.69 12 215381 196749 110177157
Helicobacter infection 328.22 10.69 5 215388 181872 110192034
Psychotic disorder 326.88 10.69 448 214945 50489 110323417
Stevens-Johnson syndrome 321.55 10.69 426 214967 46475 110327431
Duodenal ulcer perforation 316.04 10.69 6 215387 177694 110196212
Aphasia 315.75 10.69 476 214917 58521 110315385
Partial seizures with secondary generalisation 306.66 10.69 99 215294 760 110373146
Off label use 298.52 10.69 4327 211066 1495858 108878048
Tonic convulsion 297.89 10.69 137 215256 2937 110370969
Systemic lupus erythematosus 296.77 10.69 66 215327 254272 110119634
Peripheral swelling 289.85 10.69 218 215175 403816 109970090
Impaired healing 287.49 10.69 26 215367 196691 110177215
Irritable bowel syndrome 286.31 10.69 7 215386 164208 110209698
Electroencephalogram abnormal 284.48 10.69 167 215226 6006 110367900
Lower respiratory tract infection 277.83 10.69 66 215327 243040 110130866
Nasopharyngitis 277.51 10.69 217 215176 394144 109979762
Toxic epidermal necrolysis 277.39 10.69 439 214954 56288 110317618
Seizure cluster 277.09 10.69 91 215302 742 110373164
Pain in extremity 271.15 10.69 330 215063 486788 109887118
Malaise 265.26 10.69 571 214822 671248 109702658
Hyperammonaemic encephalopathy 253.04 10.69 148 215245 5286 110368620
Anticonvulsant drug level above therapeutic 251.01 10.69 94 215299 1168 110372738
Discomfort 249.90 10.69 56 215337 214651 110159255
Muscle injury 249.39 10.69 5 215388 140802 110233104
Alopecia 241.43 10.69 213 215180 364540 110009366
Toxicity to various agents 241.18 10.69 1682 213711 478873 109895033
Fibromyalgia 240.80 10.69 26 215367 170883 110203023
Asthma 240.78 10.69 93 215300 250198 110123708
Foetal exposure during pregnancy 239.94 10.69 161 215232 7344 110366562
Hypersensitivity 238.48 10.69 261 215132 403737 109970169
Osteoarthritis 237.47 10.69 36 215357 182587 110191319
Nausea 237.15 10.69 1425 213968 1234265 109139641
Infantile spasms 233.74 10.69 67 215326 324 110373582
Wheezing 230.77 10.69 104 215289 255126 110118780
Folliculitis 229.97 10.69 28 215365 167625 110206281
Pneumonia aspiration 229.22 10.69 496 214897 80737 110293169
Aura 228.23 10.69 85 215308 1039 110372867
Diarrhoea 226.04 10.69 1300 214093 1138205 109235701
Hepatocellular injury 223.29 10.69 374 215019 50268 110323638
Drug hypersensitivity 221.04 10.69 339 215054 453751 109920155
Overdose 217.99 10.69 968 214425 232826 110141080
Wound 217.53 10.69 92 215301 234345 110139561
Anger 214.55 10.69 223 215170 18784 110355122
Therapeutic product effect decreased 214.02 10.69 104 215289 244212 110129694
Neurotoxicity 213.79 10.69 332 215061 41875 110332031
Musculoskeletal stiffness 213.75 10.69 141 215252 279681 110094225
Bursitis 210.87 10.69 10 215383 129908 110243998
Mental status changes 205.93 10.69 457 214936 75665 110298241
Brain oedema 204.78 10.69 277 215116 30821 110343085
Abortion spontaneous 204.26 10.69 291 215102 33991 110339915
Aplastic anaemia 203.53 10.69 244 215149 24064 110349842
Abdominal pain upper 201.12 10.69 230 215163 348881 110025025
Psychomotor hyperactivity 195.70 10.69 219 215174 20058 110353848
Suicidal ideation 190.92 10.69 505 214888 93432 110280474
Anticonvulsant drug level below therapeutic 189.83 10.69 75 215318 1087 110372819
Hallucination, visual 188.80 10.69 303 215090 39302 110334604
Pruritus 188.33 10.69 547 214846 581013 109792893
Depressed level of consciousness 187.42 10.69 562 214831 111716 110262190
Arthritis 186.57 10.69 48 215345 167538 110206368
Treatment noncompliance 183.87 10.69 426 214967 72564 110301342
Atonic seizures 183.34 10.69 73 215320 1081 110372825
Posterior reversible encephalopathy syndrome 182.29 10.69 274 215119 33587 110340319
Joint range of motion decreased 180.99 10.69 15 215378 121817 110252089
Blood cholesterol increased 180.47 10.69 67 215326 184718 110189188
Glioblastoma 179.35 10.69 85 215308 1955 110371951
Exposure during pregnancy 178.34 10.69 722 214671 166702 110207204
Night sweats 177.45 10.69 25 215368 133958 110239948
Altered state of consciousness 176.65 10.69 364 215029 57262 110316644
Hallucination 175.27 10.69 514 214879 100918 110272988
Cholestasis 174.13 10.69 387 215006 64131 110309775
Eosinophilia 170.63 10.69 360 215033 57576 110316330
Mood altered 169.91 10.69 209 215184 21166 110352740
Encephalitis autoimmune 169.34 10.69 98 215295 3430 110370476
Suicide attempt 169.24 10.69 514 214879 102880 110271026
Dry mouth 167.80 10.69 90 215303 199858 110174048
Type 2 diabetes mellitus 165.28 10.69 69 215324 177163 110196743
Inflammation 165.09 10.69 85 215308 193153 110180753
Injection site pain 164.75 10.69 70 215323 177852 110196054
Chest pain 163.68 10.69 302 215091 376073 109997833
Hypertension 163.48 10.69 482 214911 509602 109864304
Stomatitis 161.15 10.69 173 215220 270069 110103837
Propofol infusion syndrome 160.16 10.69 85 215308 2504 110371402
Simple partial seizures 159.27 10.69 64 215329 972 110372934
Drug level increased 158.90 10.69 312 215081 47407 110326499
Delusion 158.55 10.69 213 215180 23542 110350364
Substance-induced psychotic disorder 158.32 10.69 110 215283 5314 110368592
Gastrointestinal disorder 156.77 10.69 144 215249 241808 110132098
Disorientation 156.06 10.69 392 215001 70279 110303627
Pulmonary fibrosis 155.99 10.69 11 215382 102031 110271875
Premature delivery 155.20 10.69 241 215152 30391 110343515
Drug intolerance 154.87 10.69 352 215041 406160 109967746
Disturbance in attention 153.06 10.69 359 215034 61636 110312270
Ill-defined disorder 152.95 10.69 57 215336 156796 110217110
Rash maculo-papular 152.84 10.69 401 214992 73821 110300085
Blood creatine phosphokinase increased 152.72 10.69 397 214996 72680 110301226
Lip dry 152.39 10.69 11 215382 100072 110273834
Hemiparesis 152.22 10.69 292 215101 43611 110330295
Nystagmus 149.30 10.69 146 215247 11431 110362475
Hyponatraemia 144.63 10.69 819 214574 216834 110157072
Sciatica 144.07 10.69 9 215384 92390 110281516
Mobility decreased 143.77 10.69 150 215243 237272 110136634
Back pain 143.14 10.69 319 215074 370677 110003229
Hallucination, auditory 142.66 10.69 214 215179 26183 110347723
Coma 141.54 10.69 528 214865 117341 110256565
Postictal psychosis 141.44 10.69 42 215351 235 110373671
Intentional overdose 140.76 10.69 571 214822 131930 110241976
Intellectual disability 139.72 10.69 71 215322 1908 110371998
Urticaria 138.47 10.69 256 215137 318601 110055305
Musculoskeletal pain 137.33 10.69 94 215299 182929 110190977
Pregnancy 134.09 10.69 303 215090 50764 110323142
Psoriasis 132.96 10.69 53 215340 139940 110233966
Muscle spasms 130.17 10.69 213 215180 277944 110095962
Leukopenia 128.13 10.69 602 214791 148189 110225717
Dyspepsia 128.09 10.69 110 215283 190855 110183051
Drug level decreased 127.92 10.69 169 215224 18379 110355527
Toxic encephalopathy 127.83 10.69 153 215240 15061 110358845
Confusional state 126.70 10.69 1433 213960 467247 109906659
Cough 126.63 10.69 467 214926 461174 109912732
Developmental delay 125.61 10.69 60 215333 1405 110372501
Hypoaesthesia 125.48 10.69 265 215128 313958 110059948
Grip strength decreased 124.43 10.69 8 215385 80166 110293740
Abdominal pain 123.08 10.69 547 214846 512442 109861464
Anticoagulation drug level abnormal 122.95 10.69 39 215354 281 110373625
Hepatic enzyme increased 122.88 10.69 277 215116 320615 110053291
Infection 122.79 10.69 333 215060 361867 110012039
Gastrooesophageal reflux disease 122.76 10.69 102 215291 179874 110194032
Cerebral haemorrhage 122.70 10.69 340 215053 64628 110309278
Myocardial infarction 121.27 10.69 117 215276 191966 110181940
Caesarean section 121.13 10.69 142 215251 13675 110360231
Red blood cell sedimentation rate increased 120.97 10.69 8 215385 78294 110295612
Brain neoplasm 117.41 10.69 98 215295 6239 110367667
Dyskinesia 117.41 10.69 289 215104 51157 110322749
Personality change 116.90 10.69 125 215268 10877 110363029
Glioblastoma multiforme 115.63 10.69 57 215336 1433 110372473
Lung disorder 115.62 10.69 108 215285 179939 110193967
Febrile convulsion 115.54 10.69 52 215341 1058 110372848
Contusion 114.59 10.69 173 215220 233188 110140718
Maternal exposure before pregnancy 113.65 10.69 102 215291 7163 110366743
Chest discomfort 113.15 10.69 103 215290 173745 110200161
Acute generalised exanthematous pustulosis 111.93 10.69 172 215221 21492 110352414
Injury 111.87 10.69 108 215285 177157 110196749
Low birth weight baby 111.66 10.69 47 215346 808 110373098
Pancytopenia 111.63 10.69 745 214648 208868 110165038
Delirium 110.24 10.69 538 214855 134487 110239419
Oedema peripheral 110.02 10.69 304 215089 328356 110045550
Dysarthria 109.59 10.69 387 215006 83734 110290172
Speech disorder 107.30 10.69 313 215080 61256 110312650
Haemophagocytic lymphohistiocytosis 107.08 10.69 208 215185 31351 110342555
Cardiac failure congestive 106.20 10.69 83 215310 150917 110222989
Intentional product use issue 105.00 10.69 202 215191 247704 110126202
Product administration error 103.53 10.69 226 215167 36991 110336915
Obesity 101.13 10.69 47 215346 113304 110260602
Affective disorder 101.00 10.69 117 215276 11124 110362782
Psychiatric symptom 100.24 10.69 106 215287 9107 110364799
Exposure via breast milk 100.19 10.69 46 215347 982 110372924
Cardiac arrest 99.81 10.69 691 214702 196062 110177844
Blister 97.40 10.69 184 215209 227192 110146714
Neurological decompensation 96.70 10.69 91 215302 6792 110367114
Hepatic cytolysis 96.05 10.69 280 215113 54773 110319133
Persecutory delusion 95.80 10.69 87 215306 6204 110367702
Fatigue 94.68 10.69 1734 213659 1214224 109159682
Paranoia 94.33 10.69 162 215231 22212 110351694
Hypotonia 94.30 10.69 134 215259 15611 110358295
Hypercholesterolaemia 93.74 10.69 30 215363 90807 110283099
Mood swings 93.33 10.69 163 215230 22649 110351257
Bradycardia 92.18 10.69 568 214825 154949 110218957
Knee arthroplasty 91.15 10.69 10 215383 64938 110308968
Toxic skin eruption 90.50 10.69 179 215214 27336 110346570
Injection site erythema 90.50 10.69 35 215358 94141 110279765
Acute psychosis 90.08 10.69 76 215317 4911 110368995
Small for dates baby 88.49 10.69 37 215356 625 110373281
Hip arthroplasty 88.34 10.69 5 215388 55808 110318098
Encephalitis 88.24 10.69 143 215250 18696 110355210
Sopor 87.34 10.69 209 215184 36337 110337569
Oedema 87.26 10.69 173 215220 209803 110164103
Weight increased 86.45 10.69 472 214921 419172 109954734
Tubulointerstitial nephritis 85.21 10.69 266 215127 54018 110319888
Necrosis ischaemic 85.15 10.69 45 215348 1314 110372592
Lower limb fracture 84.96 10.69 21 215372 75327 110298579
Excessive eye blinking 84.62 10.69 50 215343 1820 110372086
Cerebellar ataxia 84.59 10.69 52 215341 2036 110371870
Temporal lobe epilepsy 84.36 10.69 33 215360 465 110373441
Nasal congestion 84.26 10.69 43 215350 98239 110275667
Feeling hot 84.07 10.69 36 215357 91070 110282836
Metabolic acidosis 83.26 10.69 400 214993 99344 110274562
COVID-19 83.24 10.69 225 215168 244835 110129071
Hypothermia 82.79 10.69 168 215225 26134 110347772
Central nervous system lesion 82.49 10.69 125 215268 15428 110358478
Electrocardiogram QT prolonged 81.78 10.69 424 214969 108536 110265370
Wound infection 81.52 10.69 43 215350 96422 110277484
Joint stiffness 81.36 10.69 16 215377 67227 110306679
Blood pressure increased 81.32 10.69 246 215147 258127 110115779
Hypertransaminasaemia 81.24 10.69 159 215234 24096 110349810
Parkinsonism 81.16 10.69 151 215242 22036 110351870
Thinking abnormal 80.75 10.69 122 215271 15018 110358888
Postictal paralysis 80.64 10.69 34 215359 587 110373319
Ammonia increased 79.43 10.69 89 215304 8161 110365745
Injection site reaction 79.35 10.69 37 215356 89033 110284873
Mitochondrial DNA mutation 78.73 10.69 31 215362 445 110373461
Frequent bowel movements 78.38 10.69 21 215372 71369 110302537
Autoimmune disorder 78.36 10.69 16 215377 65467 110308439
Fluid retention 78.29 10.69 43 215350 94264 110279642
Agranulocytosis 77.77 10.69 281 215112 61479 110312427
Epileptic encephalopathy 77.43 10.69 34 215359 651 110373255
Hydrocephalus 76.96 10.69 98 215295 10277 110363629
Depressed mood 76.85 10.69 277 215116 60532 110313374
Epileptic aura 76.76 10.69 20 215373 62 110373844
Gaze palsy 76.56 10.69 59 215334 3348 110370558
Bronchitis 76.50 10.69 117 215276 156915 110216991
Mental disorder 76.22 10.69 206 215187 38585 110335321
Intracranial tumour haemorrhage 76.16 10.69 33 215360 611 110373295
Onychomadesis 75.79 10.69 3 215390 45660 110328246
Apathy 75.70 10.69 123 215270 16116 110357790
C-reactive protein increased 75.58 10.69 198 215195 217721 110156185
Coronary artery disease 75.18 10.69 23 215370 71667 110302239
Bradyphrenia 74.99 10.69 103 215290 11625 110362281
Wrong patient received product 74.77 10.69 78 215315 6596 110367310
Intentional self-injury 72.77 10.69 198 215195 37231 110336675
Postictal state 72.32 10.69 50 215343 2396 110371510
Colitis ulcerative 72.29 10.69 30 215363 77333 110296573
Wrong product administered 71.20 10.69 97 215296 10863 110363043
Acute hepatic failure 70.99 10.69 193 215200 36275 110337631
Stupor 70.89 10.69 84 215309 8181 110365725
Brain operation 70.82 10.69 35 215358 885 110373021
Eye movement disorder 70.76 10.69 91 215302 9637 110364269
Respiratory disorder neonatal 70.55 10.69 18 215375 50 110373856
Accidental death 69.94 10.69 66 215327 4943 110368963
Neck pain 69.88 10.69 82 215311 123048 110250858
Muscle twitching 69.19 10.69 169 215224 29766 110344140
Migraine 69.12 10.69 144 215249 171508 110202398
Suicidal behaviour 68.80 10.69 56 215337 3441 110370465
Electrocardiogram QRS complex prolonged 68.14 10.69 104 215289 12917 110360989
Developmental regression 68.06 10.69 17 215376 42 110373864
Abortion induced 67.95 10.69 81 215312 7938 110365968
Obsessive-compulsive disorder 67.81 10.69 77 215316 7164 110366742
Pleocytosis 67.47 10.69 42 215351 1682 110372224
Intra-abdominal pressure increased 67.14 10.69 26 215367 356 110373550
Intensive care unit acquired weakness 66.89 10.69 47 215346 2312 110371594
Myalgia 66.26 10.69 217 215176 222164 110151742
Vagal nerve stimulator implantation 66.16 10.69 23 215370 227 110373679
Tremor 66.16 10.69 643 214750 201589 110172317
Metabolic encephalopathy 66.05 10.69 94 215299 10966 110362940
Hypernatraemia 66.02 10.69 122 215271 17711 110356195
Idiopathic generalised epilepsy 65.42 10.69 17 215376 52 110373854
Maternal exposure during breast feeding 65.30 10.69 59 215334 4179 110369727
Restlessness 65.01 10.69 249 215144 56010 110317896
Injection site pruritus 64.59 10.69 11 215382 51247 110322659
Cerebral atrophy 64.54 10.69 84 215309 9001 110364905
Subdural haematoma 64.16 10.69 186 215207 36268 110337638
Sleep disorder due to a general medical condition 63.90 10.69 12 215381 52100 110321806
Hypomagnesaemia 63.16 10.69 259 215134 60111 110313795
Impulsive behaviour 62.94 10.69 52 215341 3263 110370643
Neuropsychiatric symptoms 62.41 10.69 36 215357 1252 110372654
Gait inability 62.30 10.69 106 215287 136270 110237636
Lymphopenia 62.27 10.69 196 215197 39974 110333932
Exostosis 62.20 10.69 8 215385 45948 110327958
Lethargy 62.02 10.69 352 215041 93224 110280682
Inappropriate antidiuretic hormone secretion 61.79 10.69 175 215218 33676 110340230
Affect lability 61 10.69 121 215272 18516 110355390
Productive cough 60.80 10.69 80 215313 114225 110259681
Respiratory acidosis 60.78 10.69 102 215291 13724 110360182
Multiple organ dysfunction syndrome 60.70 10.69 504 214889 151206 110222700
Rash morbilliform 60.40 10.69 76 215317 7875 110366031
Organic brain syndrome 59.52 10.69 27 215366 560 110373346
Balance disorder 59.46 10.69 410 214983 116150 110257756
Injection site swelling 59.31 10.69 23 215370 61767 110312139
Unresponsive to stimuli 59.27 10.69 264 215129 63526 110310380
Diplopia 59.15 10.69 198 215195 41696 110332210
X-ray abnormal 58.57 10.69 4 215389 38113 110335793
Nail disorder 58.25 10.69 20 215373 57915 110315991
Paraesthesia 58.02 10.69 309 215084 276212 110097694
Psychomotor skills impaired 57.69 10.69 70 215323 6988 110366918
Maternal exposure during pregnancy 57.30 10.69 753 214640 254130 110119776
Breast feeding 57.16 10.69 28 215365 694 110373212
Fall 57.06 10.69 1559 213834 601923 109771983
Atrioventricular block complete 57.05 10.69 123 215270 19959 110353947
Loss of personal independence in daily activities 56.97 10.69 130 215263 149890 110224016
Onychomycosis 56.51 10.69 5 215388 38526 110335380
Coma blister 56.26 10.69 20 215373 212 110373694
Respiratory failure 56.09 10.69 654 214739 214678 110159228
Back injury 55.85 10.69 12 215381 47387 110326519
Clonic convulsion 55.62 10.69 36 215357 1544 110372362
Blood pressure systolic increased 55.39 10.69 48 215345 82943 110290963
Coeliac disease 55.01 10.69 9 215384 43178 110330728
Irregular sleep phase 54.68 10.69 18 215375 148 110373758
Staring 54.15 10.69 45 215348 2847 110371059
Rash 54.04 10.69 1203 214190 819761 109554145
Osteoporosis 53.93 10.69 54 215339 87098 110286808
Drug eruption 53.62 10.69 227 215166 53432 110320474
Loss of consciousness 53.27 10.69 601 214792 195705 110178201
Dyspnoea exertional 53.16 10.69 75 215318 103985 110269921
Condition aggravated 51.63 10.69 1831 213562 733005 109640901
Malabsorption 51.35 10.69 63 215330 6362 110367544
Limbic encephalitis 51.32 10.69 27 215366 781 110373125
Lennox-Gastaut syndrome 50.55 10.69 20 215373 291 110373615
Upper respiratory tract infection 50.52 10.69 113 215280 131215 110242691
Asthenia 50.50 10.69 992 214401 688007 109685899
Adverse event 50.23 10.69 84 215309 108725 110265181
Diabetes insipidus 50.22 10.69 63 215330 6507 110367399
Hippocampal sclerosis 49.79 10.69 18 215375 201 110373705
Nervous system disorder 49.37 10.69 155 215238 31566 110342340
Finger deformity 49.34 10.69 4 215389 33088 110340818
Flushing 49.14 10.69 80 215313 104656 110269250
Stress 48.93 10.69 81 215312 105267 110268639
Major depression 48.90 10.69 80 215313 10541 110363365
Chronic obstructive pulmonary disease 48.81 10.69 86 215307 109072 110264834
Automatism epileptic 48.52 10.69 12 215381 28 110373878
Cerebellar atrophy 48.45 10.69 32 215361 1421 110372485
Haemorrhage intracranial 48.30 10.69 145 215248 28824 110345082
Myocardial depression 48.03 10.69 25 215368 707 110373199
Depressive symptom 48.03 10.69 70 215323 8344 110365562
Systemic inflammatory response syndrome 48.00 10.69 89 215304 12954 110360952
Blood pressure fluctuation 47.88 10.69 45 215348 74779 110299127
Cerebral salt-wasting syndrome 47.80 10.69 19 215374 280 110373626
Psychomotor retardation 47.68 10.69 67 215326 7725 110366181
Mania 47.63 10.69 117 215276 20679 110353227
Laryngitis 47.47 10.69 12 215381 42399 110331507
Acute myocardial infarction 47.31 10.69 56 215337 83721 110290185
Granuloma annulare 47.12 10.69 26 215367 829 110373077
Palpitations 46.97 10.69 156 215237 159056 110214850
Live birth 46.60 10.69 40 215353 69444 110304462
Autism spectrum disorder 46.56 10.69 35 215358 1913 110371993
Retinogram abnormal 46.37 10.69 20 215373 366 110373540
Magnetic resonance imaging head abnormal 46.37 10.69 45 215348 3490 110370416
Stillbirth 46.28 10.69 49 215344 4215 110369691
Acidosis hyperchloraemic 45.90 10.69 32 215361 1554 110372352
CSF oligoclonal band present 45.62 10.69 21 215372 451 110373455
Drop attacks 45.46 10.69 28 215365 1100 110372806
Mucosal inflammation 45.43 10.69 332 215061 95809 110278097
Eastern Cooperative Oncology Group performance status worsened 45.09 10.69 41 215352 2928 110370978
Headache 44.74 10.69 1343 214050 881034 109492872
Cholestatic liver injury 44.50 10.69 63 215330 7313 110366593
Premature baby 44.40 10.69 51 215342 4804 110369102
Hypoventilation 44.36 10.69 66 215327 8015 110365891
Hemianopia 44.33 10.69 40 215353 2828 110371078
Constipation 44.28 10.69 464 214929 357322 110016584
Osteonecrosis of jaw 44.25 10.69 19 215374 47998 110325908
Catatonia 43.98 10.69 79 215314 11221 110362685
Brain herniation 43.87 10.69 69 215324 8794 110365112
Metastases to central nervous system 43.66 10.69 120 215273 22697 110351209
Autonomic nervous system imbalance 43.51 10.69 55 215338 5725 110368181
Foot deformity 43.40 10.69 20 215373 48460 110325446
Rhinorrhoea 43.14 10.69 84 215309 102582 110271324
Retinitis 42.87 10.69 6 215387 32321 110341585
Road traffic accident 42.47 10.69 91 215302 107307 110266599
Brain malformation 42.39 10.69 12 215381 55 110373851
Skin ulcer 42.24 10.69 37 215356 63608 110310298
Drug level below therapeutic 42.14 10.69 79 215314 11594 110362312
Influenza 41.88 10.69 178 215215 168923 110204983
Automatism 41.86 10.69 16 215377 211 110373695
Ear pain 41.72 10.69 26 215367 53200 110320706
Transaminases increased 41.70 10.69 238 215155 63152 110310754
Ventricular fibrillation 41.46 10.69 175 215218 41138 110332768
Deja vu 41.18 10.69 13 215380 92 110373814
Hypokalaemia 40.98 10.69 539 214854 181909 110191997
Pneumatosis 40.73 10.69 25 215368 976 110372930
Cross sensitivity reaction 40.37 10.69 52 215341 5515 110368391
Dry eye 40.07 10.69 30 215363 55763 110318143
Head injury 39.94 10.69 178 215215 42839 110331067
Taste disorder 39.90 10.69 41 215352 65346 110308560
Disease recurrence 39.84 10.69 228 215165 60556 110313350
Convulsive threshold lowered 39.72 10.69 25 215368 1021 110372885
Mutism 39.66 10.69 39 215354 3074 110370832
Hepatic cirrhosis 39.49 10.69 44 215349 67582 110306324
Torsade de pointes 39.47 10.69 115 215278 22485 110351421
Burning sensation 39.36 10.69 46 215347 69166 110304740
Verbal abuse 39.13 10.69 17 215376 317 110373589
Learning disorder 39.07 10.69 22 215371 730 110373176
Haemoptysis 38.91 10.69 49 215344 71305 110302601
Gamma-glutamyltransferase increased 38.90 10.69 228 215165 61081 110312825
Injection site bruising 38.87 10.69 26 215367 51237 110322669
Abdominal distension 38.79 10.69 192 215201 174911 110198995
Herpes zoster 38.70 10.69 97 215296 108282 110265624
Apnoea 38.13 10.69 83 215310 13556 110360350
Meningioma 38.11 10.69 51 215342 5614 110368292
Angina pectoris 38.08 10.69 39 215354 62256 110311650
Ventricular tachycardia 37.78 10.69 195 215198 49814 110324092
Manic symptom 37.75 10.69 16 215377 280 110373626
Bronchiectasis 37.74 10.69 12 215381 36481 110337425
Liver injury 37.45 10.69 158 215235 150255 110223651
Asterixis 37.35 10.69 38 215355 3120 110370786
Patent ductus arteriosus 37.31 10.69 14 215379 175 110373731
JC polyomavirus test 37.24 10.69 10 215383 36 110373870
Eye pruritus 37.21 10.69 9 215384 32766 110341140
Plasmapheresis 37.20 10.69 22 215371 802 110373104
Cataract 37.02 10.69 61 215332 79424 110294482
Ulcer 36.75 10.69 19 215374 43097 110330809
Epileptic psychosis 36.68 10.69 11 215382 64 110373842
Product packaging confusion 36.64 10.69 17 215376 372 110373534
Epidermolysis bullosa 36.56 10.69 17 215376 374 110373532
Congenital cyst 36.42 10.69 8 215385 8 110373898
Accidental overdose 36.35 10.69 198 215195 51636 110322270
Rectal haemorrhage 36.33 10.69 116 215277 119717 110254189
Glomerulonephritis minimal lesion 36.31 10.69 24 215369 1067 110372839
Language disorder 36.26 10.69 41 215352 3797 110370109
Precocious puberty 36.15 10.69 17 215376 384 110373522
MELAS syndrome 36.12 10.69 16 215377 313 110373593
Crying 36.07 10.69 121 215272 25507 110348399
Weight decreased 36.06 10.69 668 214725 467389 109906517
Bradypnoea 35.64 10.69 62 215331 8587 110365319
Dystonia 35.58 10.69 121 215272 25684 110348222
Erythema multiforme 35.55 10.69 106 215287 20991 110352915
Hot flush 35.34 10.69 46 215347 65990 110307916
Nodule 35.07 10.69 10 215383 32621 110341285
Brief psychotic disorder, with postpartum onset 35.02 10.69 9 215384 26 110373880
Disease progression 34.73 10.69 668 214725 243366 110130540
Meningitis aseptic 34.64 10.69 66 215327 9804 110364102
Procedural pain 34.53 10.69 13 215380 35552 110338354
Product name confusion 34.52 10.69 14 215379 218 110373688
Screaming 34.47 10.69 45 215348 4836 110369070
Macroglossia 34.37 10.69 26 215367 1435 110372471
Nicotinic acid deficiency 34.29 10.69 14 215379 222 110373684
Quadriparesis 34.18 10.69 44 215349 4663 110369243
Neutropenia 34.00 10.69 963 214430 373657 110000249
Angiofibroma 33.94 10.69 12 215381 125 110373781
Therapeutic response unexpected 33.94 10.69 113 215280 23730 110350176
CSF protein increased 33.90 10.69 26 215367 1465 110372441
Intestinal ischaemia 33.89 10.69 88 215305 16091 110357815
Gingival hypertrophy 33.86 10.69 42 215351 4289 110369617
Oropharyngeal pain 33.74 10.69 142 215251 135134 110238772
Axillary lymphadenectomy 33.68 10.69 11 215382 88 110373818
Neurosurgery 33.46 10.69 11 215382 90 110373816
Throat irritation 33.34 10.69 33 215360 53519 110320387
Sleep disorder 33.31 10.69 238 215155 198406 110175500
Tuberous sclerosis complex 33.19 10.69 12 215381 134 110373772
Hyperthermia 33.16 10.69 104 215289 21168 110352738
Failure to suspend medication 33.05 10.69 17 215376 469 110373437
Foetal growth restriction 33.02 10.69 35 215358 3015 110370891
Gout 32.86 10.69 15 215378 36551 110337355
Slow speech 32.86 10.69 37 215356 3411 110370495
Coordination abnormal 32.79 10.69 116 215277 25112 110348794
Attention deficit hyperactivity disorder 32.65 10.69 42 215351 4449 110369457
Bradyarrhythmia 32.55 10.69 44 215349 4890 110369016
Lichenoid keratosis 32.50 10.69 50 215343 6252 110367654
Speech disorder developmental 32.50 10.69 21 215372 898 110373008
Pneumonia 32.41 10.69 1387 214006 875327 109498579
Illness 32.18 10.69 70 215323 82101 110291805
Full blood count abnormal 32.15 10.69 37 215356 56015 110317891
Hyperhidrosis 32.09 10.69 223 215170 187075 110186831
Non-24-hour sleep-wake disorder 32.01 10.69 9 215384 40 110373866
Lupus-like syndrome 31.87 10.69 20 215373 40772 110333134
Tooth disorder 31.79 10.69 9 215384 29500 110344406
Gliosis 31.63 10.69 19 215374 713 110373193
Pulmonary arterial hypertension 31.46 10.69 12 215381 32556 110341350
Congenital megaureter 31.46 10.69 6 215387 0 110373906
Accidental poisoning 31.39 10.69 31 215362 2456 110371450
Macular degeneration 31.26 10.69 3 215390 21656 110352250
Educational problem 31.13 10.69 17 215376 531 110373375
Diverticulitis 31.06 10.69 35 215358 53487 110320419
Crystal nephropathy 30.91 10.69 27 215366 1829 110372077
Astrocytoma, low grade 30.82 10.69 11 215382 118 110373788
Impulse-control disorder 30.81 10.69 29 215364 2165 110371741
Dysmorphism 30.69 10.69 18 215375 646 110373260
Glioma 30.69 10.69 20 215373 868 110373038
Creutzfeldt-Jakob disease 30.65 10.69 13 215380 228 110373678
Autoimmune hepatitis 30.48 10.69 80 215313 14724 110359182
Apraxia 30.40 10.69 36 215357 3504 110370402
Retrograde amnesia 30.36 10.69 19 215374 768 110373138
Chronic sinusitis 30.28 10.69 6 215387 25078 110348828
Diabetes mellitus 30.27 10.69 96 215297 99285 110274621
Pleural effusion 30.24 10.69 212 215181 177497 110196409
Vanishing bile duct syndrome 30.20 10.69 34 215359 3134 110370772
Blood lactic acid increased 30.06 10.69 83 215310 15738 110358168
Prostate cancer 30.04 10.69 18 215375 37623 110336283
Back disorder 29.93 10.69 3 215390 20919 110352987
Cardiac disorder 29.85 10.69 65 215328 76215 110297691
Sinus congestion 29.79 10.69 11 215382 30448 110343458
Cellulitis 29.77 10.69 135 215258 125881 110248025
Hyperkalaemia 29.44 10.69 150 215243 135646 110238260
Blood gases abnormal 29.39 10.69 23 215370 1335 110372571
Cortical dysplasia 29.33 10.69 8 215385 31 110373875
Endotracheal intubation 29.27 10.69 47 215346 6097 110367809
Herpes simplex encephalitis 29.13 10.69 19 215374 826 110373080
Neuropathy peripheral 28.99 10.69 217 215176 179060 110194846
Eosinophilic pleural effusion 28.94 10.69 16 215377 512 110373394
Sedation 28.67 10.69 233 215160 69450 110304456
CSF measles antibody positive 28.60 10.69 9 215384 63 110373843
Ischaemic stroke 28.51 10.69 157 215236 41106 110332800
Petechiae 28.43 10.69 105 215288 23212 110350694
Agnosia 28.42 10.69 13 215380 275 110373631
Chills 28.35 10.69 236 215157 190344 110183562
Opsoclonus myoclonus 28.34 10.69 13 215380 277 110373629
CSWS syndrome 28.20 10.69 8 215385 37 110373869
Cerebral amyloid angiopathy 28.20 10.69 16 215377 539 110373367
Food allergy 28.17 10.69 3 215390 19945 110353961
Rubella antibody positive 28.12 10.69 9 215384 67 110373839
Purple glove syndrome 28.04 10.69 13 215380 284 110373622
Neuroleptic malignant syndrome 27.99 10.69 136 215257 33923 110339983
Cerebral haemorrhage neonatal 27.83 10.69 6 215387 5 110373901
Plasma cell myeloma 27.76 10.69 50 215343 62886 110311020
Thrombosis 27.76 10.69 113 215280 108549 110265357
Altered pitch perception 27.55 10.69 7 215386 19 110373887
Hostility 27.54 10.69 30 215363 2666 110371240
Cerebral venous sinus thrombosis 27.48 10.69 31 215362 2864 110371042
Myelosuppression 27.44 10.69 93 215300 94247 110279659
Localised infection 27.41 10.69 26 215367 43022 110330884
Hepatic function abnormal 27.28 10.69 280 215113 89015 110284891
Bradykinesia 27.19 10.69 63 215330 10725 110363181
Tongue biting 27.09 10.69 31 215362 2908 110370998
Mucosal ulceration 27.00 10.69 28 215365 2351 110371555
Obstructive airways disorder 26.97 10.69 30 215363 46119 110327787
Renal fusion anomaly 26.83 10.69 6 215387 7 110373899
Therapeutic response shortened 26.80 10.69 12 215381 29571 110344335
Cardiac arrest neonatal 26.80 10.69 7 215386 22 110373884
Throat tightness 26.75 10.69 16 215377 33473 110340433
Neurodevelopmental disorder 26.72 10.69 9 215384 80 110373826
Hypometabolism 26.63 10.69 11 215382 180 110373726
Spinal stenosis 26.57 10.69 3 215390 19053 110354853
Laboratory test abnormal 26.49 10.69 28 215365 44051 110329855
Central nervous system infection 26.47 10.69 24 215369 1708 110372198
Gastrointestinal haemorrhage 26.46 10.69 201 215192 165317 110208589
Arteriosclerosis coronary artery 26.44 10.69 8 215385 25110 110348796
Congenital renal disorder 26.39 10.69 6 215387 8 110373898
Bladder cancer 26.36 10.69 4 215389 20288 110353618
Dry skin 26.23 10.69 114 215279 107539 110266367
Circulatory collapse 26.07 10.69 158 215235 42835 110331071
Terminal insomnia 26.04 10.69 25 215368 1913 110371993
Mental impairment 25.99 10.69 100 215293 22539 110351367
Haematochezia 25.97 10.69 126 215267 115398 110258508
Ultrasound ovary abnormal 25.96 10.69 9 215384 88 110373818
Sneezing 25.94 10.69 15 215378 31969 110341937
Cell death 25.83 10.69 43 215350 5748 110368158
Lymphocyte adoptive therapy 25.82 10.69 10 215383 137 110373769
Heart rate increased 25.76 10.69 169 215224 143665 110230241
Musculoskeletal discomfort 25.69 10.69 7 215386 23531 110350375
Serratia sepsis 25.68 10.69 12 215381 267 110373639
Paraesthesia oral 25.64 10.69 17 215376 33654 110340252
Mixed liver injury 25.61 10.69 66 215327 12013 110361893
Dysphagia 25.57 10.69 431 214962 153169 110220737
Brain tumour operation 25.52 10.69 9 215384 93 110373813
Anaplastic astrocytoma 25.43 10.69 10 215383 143 110373763
Febrile neutropenia 25.34 10.69 449 214944 316318 110057588
Sinus arrest 25.25 10.69 36 215357 4206 110369700
Neonatal pneumonia 24.92 10.69 7 215386 31 110373875
Necrobiosis lipoidica diabeticorum 24.92 10.69 7 215386 31 110373875
Breast cancer 24.87 10.69 23 215370 38519 110335387
Diffuse cutaneous mastocytosis 24.74 10.69 7 215386 32 110373874
Ascites 24.67 10.69 95 215298 92713 110281193
Malignant catatonia 24.64 10.69 16 215377 690 110373216
Atrial fibrillation 24.41 10.69 308 215085 229334 110144572
Vomiting 24.37 10.69 1489 213904 909186 109464720
Bladder sphincter atony 24.34 10.69 11 215382 226 110373680
Clonus 24.32 10.69 53 215340 8663 110365243
Drug clearance increased 24.31 10.69 13 215380 389 110373517
Tuberculosis 24.28 10.69 3 215390 17771 110356135
Therapy partial responder 24.28 10.69 139 215254 36922 110336984
Blood pressure systolic abnormal 24.26 10.69 9 215384 24841 110349065
Mitochondrial encephalomyopathy 24.24 10.69 9 215384 109 110373797
Astrocytoma malignant 24.23 10.69 7 215386 35 110373871
Craniotomy 24.13 10.69 15 215378 599 110373307
Infusion site reaction 24.12 10.69 3 215390 17679 110356227
Sinus node dysfunction 24.10 10.69 54 215339 8993 110364913
Intestinal intraepithelial lymphocytes increased 24.08 10.69 11 215382 232 110373674
Brain injury 23.94 10.69 69 215324 13407 110360499
Hypersensitivity vasculitis 23.87 10.69 46 215347 6891 110367015
Pain of skin 23.74 10.69 5 215388 20024 110353882
Abulia 23.69 10.69 20 215373 1293 110372613
Injection site rash 23.69 10.69 8 215385 23411 110350495
Slow response to stimuli 23.66 10.69 24 215369 1964 110371942
Blood pressure diastolic decreased 23.65 10.69 21 215372 35864 110338042
Oculogyric crisis 23.52 10.69 33 215360 3799 110370107
Brain abscess 23.41 10.69 45 215348 6729 110367177
Astrocytoma 23.37 10.69 11 215382 249 110373657
Atrial septal defect 23.33 10.69 25 215368 2180 110371726
Hypertonia 23.32 10.69 51 215342 8355 110365551
Myositis 23.30 10.69 16 215377 31100 110342806
Injection site urticaria 23.29 10.69 3 215390 17212 110356694
Acute coronary syndrome 23.20 10.69 8 215385 23104 110350802
Rhesus incompatibility 23.18 10.69 6 215387 18 110373888
Neonatal hypotension 23.16 10.69 7 215386 42 110373864
Respiratory disorder 23.13 10.69 67 215326 71315 110302591
Sinus disorder 22.99 10.69 18 215375 32710 110341196
Walking aid user 22.98 10.69 10 215383 25065 110348841
Device expulsion 22.98 10.69 16 215377 30875 110343031
Blepharospasm 22.93 10.69 45 215348 54806 110319100
Respiratory tract congestion 22.93 10.69 16 215377 30841 110343065
Brain neoplasm malignant 22.93 10.69 23 215370 1857 110372049
Eye pain 22.82 10.69 39 215354 50060 110323846
Sputum discoloured 22.82 10.69 13 215380 27932 110345974
Pulmonary valve stenosis congenital 22.76 10.69 5 215388 5 110373901
Anaphylactic shock 22.69 10.69 41 215352 51505 110322401
Hypoxic-ischaemic encephalopathy 22.67 10.69 52 215341 8795 110365111
Anaemia 22.65 10.69 854 214539 546232 109827674
Dysmetria 22.59 10.69 20 215373 1379 110372527
Oropharyngeal oedema 22.54 10.69 13 215380 452 110373454
Rash scarlatiniform 22.53 10.69 12 215381 356 110373550
Feeling abnormal 22.48 10.69 234 215159 180477 110193429
Gait disturbance 22.47 10.69 705 214688 277503 110096403
Heart rate decreased 22.45 10.69 84 215309 82672 110291234
Incoherent 22.39 10.69 50 215343 8308 110365598
Blood oestrogen increased 22.38 10.69 10 215383 200 110373706
Blood brain barrier defect 22.02 10.69 10 215383 208 110373698
White matter lesion 22.00 10.69 27 215366 2727 110371179
Cardiopulmonary failure 21.99 10.69 48 215345 7855 110366051
Product dispensing error 21.97 10.69 76 215317 16269 110357637
Melaena 21.94 10.69 65 215328 68692 110305214
Radiation necrosis 21.88 10.69 16 215377 838 110373068
Selective eating disorder 21.77 10.69 11 215382 292 110373614
Haemoglobin decreased 21.70 10.69 347 215046 248380 110125526
Consciousness fluctuating 21.67 10.69 24 215369 2172 110371734
Aspiration 21.65 10.69 117 215276 30416 110343490
Echopraxia 21.65 10.69 7 215386 54 110373852
Hypersomnia 21.60 10.69 110 215283 27951 110345955
Catastrophic reaction 21.47 10.69 6 215387 26 110373880
Wrong patient 21.41 10.69 20 215373 1479 110372427
Medical observation 21.38 10.69 10 215383 223 110373683
Product residue present 21.36 10.69 32 215361 3909 110369997
Injection site warmth 21.35 10.69 4 215389 17401 110356505
Lymphangioleiomyomatosis 21.30 10.69 10 215383 225 110373681
Platelet dysfunction 21.22 10.69 13 215380 506 110373400
Bone pain 21.20 10.69 61 215332 65072 110308834
Balamuthia infection 21.18 10.69 8 215385 102 110373804
Eosinophilic cystitis 21.16 10.69 9 215384 159 110373747
Angiomyolipoma 21.14 10.69 11 215382 311 110373595
Unmasking of previously unidentified disease 21.13 10.69 27 215366 2841 110371065
Post stroke depression 21.09 10.69 5 215388 9 110373897
Cerebral artery stenosis 21.02 10.69 16 215377 891 110373015
Congenital neurological disorder 20.97 10.69 4 215389 0 110373906
Injection site haemorrhage 20.97 10.69 20 215373 33008 110340898
Executive dysfunction 20.92 10.69 12 215381 413 110373493
Coagulopathy 20.91 10.69 144 215249 40767 110333139
Cerebral haematoma 20.81 10.69 53 215340 9579 110364327
Dysphemia 20.78 10.69 32 215361 4005 110369901
Bronchospasm 20.78 10.69 17 215376 30222 110343684
Glycosylated haemoglobin increased 20.74 10.69 10 215383 23609 110350297
Congenital inguinal hernia 20.74 10.69 5 215388 10 110373896
Ulcer haemorrhage 20.69 10.69 9 215384 22562 110351344
Staphylococcal scalded skin syndrome 20.63 10.69 13 215380 532 110373374
Respiratory distress 20.58 10.69 215 215178 68659 110305247
Psychomotor disadaptation syndrome 20.50 10.69 8 215385 112 110373794
Breath sounds abnormal 20.48 10.69 12 215381 25392 110348514
Ankylosing spondylitis 20.46 10.69 3 215390 15609 110358297
Hypocalcaemia 20.46 10.69 206 215187 65160 110308746
Citrobacter test positive 20.42 10.69 7 215386 66 110373840
Ocular hyperaemia 20.37 10.69 28 215365 39258 110334648
Diverticulum 20.31 10.69 3 215390 15523 110358383
Leukoencephalopathy 20.28 10.69 51 215342 9144 110364762
Gene mutation 20.26 10.69 29 215364 3400 110370506
Ear infection 20.24 10.69 59 215334 62673 110311233
Product prescribing error 20.24 10.69 170 215223 51161 110322745
Schizophreniform disorder 20.23 10.69 9 215384 178 110373728
Cardiac failure 20.18 10.69 251 215142 187375 110186531
Pregnancy with implant contraceptive 20.17 10.69 24 215369 2348 110371558
Systemic infection 20.15 10.69 53 215340 9766 110364140
Diabetes mellitus inadequate control 20.14 10.69 17 215376 29758 110344148
Maternal drugs affecting foetus 20.12 10.69 20 215373 1597 110372309
Musculoskeletal chest pain 20.09 10.69 16 215377 28831 110345075
Pulmonary hypertension 20.04 10.69 49 215344 55171 110318735
Salivary hypersecretion 20.04 10.69 77 215316 17344 110356562
Intrauterine infection 19.96 10.69 7 215386 71 110373835
Bile acid malabsorption 19.70 10.69 12 215381 462 110373444
Presyncope 19.68 10.69 41 215352 48846 110325060
Microvillous inclusion disease 19.67 10.69 10 215383 269 110373637
Osteonecrosis 19.65 10.69 22 215371 33719 110340187
Anaphylactic reaction 19.62 10.69 136 215257 114164 110259742
Frontal lobe epilepsy 19.58 10.69 6 215387 38 110373868
Vitamin B6 deficiency 19.57 10.69 13 215380 583 110373323
Haematuria traumatic 19.56 10.69 11 215382 364 110373542
Psychological trauma 19.55 10.69 20 215373 1653 110372253
Poverty of thought content 19.54 10.69 7 215386 76 110373830
Learning disability 19.35 10.69 9 215384 198 110373708
Placental infarction 19.30 10.69 8 215385 132 110373774
Choreoathetosis 19.30 10.69 20 215373 1678 110372228
Inappropriate affect 19.29 10.69 20 215373 1679 110372227
Heart rate irregular 19.25 10.69 23 215370 34251 110339655
Carpal tunnel syndrome 19.22 10.69 10 215383 22600 110351306
Unintended pregnancy 19.21 10.69 34 215359 4774 110369132
Jaundice 19.18 10.69 188 215205 59048 110314858
Hemianopia homonymous 19.13 10.69 19 215374 1516 110372390
Conjunctival irritation 19.09 10.69 8 215385 136 110373770
Cryptitis 19.08 10.69 11 215382 382 110373524
Lipids 19.07 10.69 5 215388 16 110373890
Benign cardiac neoplasm 19.06 10.69 6 215387 42 110373864
Paresis 19.02 10.69 34 215359 4810 110369096
Hypotension 19.02 10.69 1223 214170 522626 109851280
Skin disorder 19.01 10.69 34 215359 42879 110331027
Squamous cell carcinoma of skin 19.00 10.69 5 215388 17198 110356708
Pulmonary mass 18.93 10.69 27 215366 37274 110336632
Dyscalculia 18.93 10.69 8 215385 139 110373767
Accidental exposure to product by child 18.83 10.69 27 215366 3171 110370735
Suspiciousness 18.82 10.69 14 215379 753 110373153
Inappropriate schedule of product administration 18.81 10.69 281 215112 203356 110170550
Paraplegia 18.80 10.69 39 215354 6161 110367745
Craniocerebral injury 18.79 10.69 38 215355 5896 110368010
Holmes tremor 18.74 10.69 4 215389 3 110373903
Intestinal obstruction 18.72 10.69 48 215345 53179 110320727
Memory impairment 18.61 10.69 509 214884 196435 110177471
Coronary artery occlusion 18.57 10.69 4 215389 15768 110358138
Pregnancy on oral contraceptive 18.55 10.69 15 215378 913 110372993
Proctitis 18.54 10.69 5 215388 16922 110356984
Posture abnormal 18.53 10.69 32 215361 4406 110369500
Gingival pain 18.51 10.69 4 215389 15732 110358174
Tenderness 18.48 10.69 18 215375 29419 110344487
Cerebral disorder 18.47 10.69 41 215352 6785 110367121
Anticonvulsant drug level therapeutic 18.41 10.69 5 215388 19 110373887
Blood pressure diastolic abnormal 18.38 10.69 14 215379 25801 110348105
Dysgeusia 18.36 10.69 72 215321 69913 110303993
Cerebellar syndrome 18.36 10.69 39 215354 6263 110367643
Drug effective for unapproved indication 18.29 10.69 65 215328 14102 110359804
Drug tolerance decreased 18.29 10.69 16 215377 27524 110346382
Vitamin B6 decreased 18.26 10.69 6 215387 49 110373857
General physical health deterioration 18.24 10.69 661 214732 424634 109949272
Brain lobectomy 18.21 10.69 4 215389 4 110373902
Basal cell carcinoma 18.19 10.69 38 215355 45232 110328674
Dermatitis exfoliative 18.17 10.69 56 215337 11291 110362615
Febrile infection-related epilepsy syndrome 18.13 10.69 7 215386 95 110373811
Atrioventricular block 18.12 10.69 73 215320 16804 110357102
Obsessive-compulsive symptom 18.12 10.69 10 215383 319 110373587
Pain in jaw 18.11 10.69 46 215347 51131 110322775
Moaning 18.11 10.69 18 215375 1437 110372469
Device dislocation 18.10 10.69 21 215372 31683 110342223
Euthyroid sick syndrome 18.07 10.69 7 215386 96 110373810
COVID-19 immunisation 18.06 10.69 17 215376 1269 110372637
Lipids abnormal 17.93 10.69 13 215380 672 110373234
Priapism 17.93 10.69 37 215356 5824 110368082
Hallucinations, mixed 17.92 10.69 47 215346 8646 110365260
Uveitis 17.87 10.69 10 215383 21700 110352206
Teratogenicity 17.77 10.69 9 215384 240 110373666
Scarlet fever 17.68 10.69 8 215385 165 110373741
Congenital muscle absence 17.65 10.69 5 215388 23 110373883
Metastases to meninges 17.64 10.69 34 215359 5094 110368812
Psychotic symptom 17.63 10.69 29 215364 3838 110370068
Akathisia 17.57 10.69 73 215320 17040 110356866
Hyperbilirubinaemia 17.52 10.69 111 215282 30560 110343346
B-lymphocyte abnormalities 17.50 10.69 8 215385 169 110373737
Product selection error 17.46 10.69 11 215382 450 110373456
Vasoplegia syndrome 17.42 10.69 35 215358 5404 110368502
Probiotic therapy 17.41 10.69 8 215385 171 110373735
Stereotypy 17.35 10.69 15 215378 1002 110372904
Intrusive thoughts 17.34 10.69 13 215380 708 110373198
Metastases to lymph nodes 17.32 10.69 4 215389 15028 110358878
Radiculopathy 17.27 10.69 8 215385 19328 110354578
Drooling 17.24 10.69 41 215352 7098 110366808
Alcohol use disorder 17.19 10.69 6 215387 60 110373846
Dysgraphia 17.18 10.69 32 215361 4673 110369233
Anal spasm 17.16 10.69 8 215385 177 110373729
Acquired macroglossia 17.15 10.69 9 215384 259 110373647
Device leakage 17.09 10.69 5 215388 16043 110357863
Gastric disorder 17.07 10.69 24 215369 33333 110340573
Immunodeficiency 17.00 10.69 31 215362 38807 110335099
Autoimmune encephalopathy 16.84 10.69 8 215385 185 110373721
Cholelithiasis 16.80 10.69 65 215328 63357 110310549
Upper-airway cough syndrome 16.78 10.69 5 215388 15852 110358054
Poor personal hygiene 16.78 10.69 12 215381 607 110373299
Cerebral cyst 16.76 10.69 11 215382 483 110373423
Gastric pH increased 16.76 10.69 6 215387 65 110373841
Disorganised speech 16.75 10.69 26 215367 3277 110370629
Fluid intake reduced 16.74 10.69 40 215353 6946 110366960
Limb discomfort 16.67 10.69 34 215359 40820 110333086
Administration site discomfort 16.64 10.69 8 215385 190 110373716
Morbid thoughts 16.59 10.69 14 215379 905 110373001
Rotator cuff syndrome 16.54 10.69 6 215387 16788 110357118
Interleukin level increased 16.49 10.69 18 215375 1603 110372303
Mitochondrial cytopathy 16.42 10.69 10 215383 385 110373521
Pemphigoid 16.41 10.69 79 215314 19628 110354278
Burnout syndrome 16.39 10.69 10 215383 386 110373520
Juvenile myoclonic epilepsy 16.36 10.69 6 215387 70 110373836
Panniculitis 16.33 10.69 5 215388 15577 110358329
Vasculitis 16.27 10.69 28 215365 35845 110338061
Nasal polyps 16.27 10.69 3 215390 13197 110360709
Guillain-Barre syndrome 16.26 10.69 52 215341 10692 110363214
Meningitis 16.25 10.69 55 215338 11647 110362259
Vasogenic cerebral oedema 16.23 10.69 21 215372 2237 110371669
Movement disorder 16.22 10.69 124 215269 36280 110337626
Abortion 16.19 10.69 18 215375 1636 110372270
Food refusal 16.18 10.69 14 215379 936 110372970
Brain death 16.15 10.69 38 215355 6535 110367371
Right ventricular failure 16.15 10.69 16 215377 25938 110347968
Product administered to patient of inappropriate age 16.11 10.69 43 215350 7993 110365913
Cranial nerve disorder 16.06 10.69 16 215377 1281 110372625
Hyperkinesia 16.06 10.69 25 215368 3159 110370747
Thyroid atrophy 16.00 10.69 9 215384 298 110373608
SJS-TEN overlap 16.00 10.69 19 215374 1855 110372051
Contraindicated product prescribed 15.98 10.69 21 215372 2272 110371634
Impaired quality of life 15.97 10.69 21 215372 29996 110343910
Angina unstable 15.96 10.69 6 215387 16426 110357480
Squamous cell carcinoma 15.94 10.69 8 215385 18455 110355451
Blindness cortical 15.93 10.69 15 215378 1120 110372786
Subacute sclerosing panencephalitis 15.92 10.69 6 215387 76 110373830
Renal tubular acidosis 15.90 10.69 31 215362 4684 110369222
Fistula 15.87 10.69 5 215388 15294 110358612
Rebound effect 15.86 10.69 64 215329 14742 110359164
Faeces discoloured 15.86 10.69 26 215367 33922 110339984
Encephalomalacia 15.84 10.69 17 215376 1485 110372421
Gangrene 15.82 10.69 6 215387 16335 110357571
Blood phosphorus increased 15.82 10.69 6 215387 16334 110357572
Niemann-Pick disease 15.77 10.69 5 215388 36 110373870
Pancreatitis 15.76 10.69 263 215130 93270 110280636
Ganglioglioma 15.73 10.69 3 215390 0 110373906
Electrocardiogram delta waves abnormal 15.73 10.69 3 215390 0 110373906
Perseveration 15.70 10.69 10 215383 417 110373489
Mitochondrial toxicity 15.70 10.69 25 215368 3220 110370686
Product taste abnormal 15.70 10.69 22 215371 2530 110371376
Acute disseminated encephalomyelitis 15.64 10.69 10 215383 420 110373486
Device malfunction 15.62 10.69 16 215377 25542 110348364
Fracture 15.60 10.69 92 215301 24696 110349210
Pulmonary embolism 15.60 10.69 309 215084 214165 110159741
Oligodendroglioma 15.53 10.69 7 215386 143 110373763
Injection site mass 15.51 10.69 15 215378 24598 110349308
Transplant rejection 15.45 10.69 15 215378 24552 110349354
Biopsy brain 15.45 10.69 4 215389 12 110373894
Duplicate therapy error 15.45 10.69 10 215383 429 110373477
Haemofiltration 15.39 10.69 7 215386 146 110373760
Respiratory symptom 15.30 10.69 5 215388 14940 110358966
Use of accessory respiratory muscles 15.22 10.69 12 215381 704 110373202
Sinus bradycardia 15.20 10.69 104 215289 29379 110344527
Glycosuria 15.19 10.69 22 215371 2608 110371298
Ventricular septal defect 15.18 10.69 12 215381 707 110373199
Renal tubular disorder 15.15 10.69 40 215353 7389 110366517
Rhinitis allergic 15.12 10.69 8 215385 17914 110355992
Hypercapnia 15.10 10.69 52 215341 11107 110362799
Prostatic specific antigen increased 15.09 10.69 3 215390 12508 110361398
Porphyria 15.06 10.69 8 215385 236 110373670
Hepatitis cholestatic 15.05 10.69 71 215322 17495 110356411
Sudden death 15.01 10.69 90 215303 24305 110349601
Hiatus hernia 15.01 10.69 19 215374 27587 110346319
Serum ferritin increased 14.99 10.69 54 215339 11793 110362113
Therapy non-responder 14.99 10.69 407 214986 156900 110217006
Adactyly 14.98 10.69 4 215389 14 110373892
Disinhibition 14.96 10.69 24 215369 3110 110370796
Illusion 14.95 10.69 19 215374 1988 110371918
Nail dystrophy 14.93 10.69 15 215378 1213 110372693
Hypotonia neonatal 14.82 10.69 6 215387 93 110373813
Tinnitus 14.81 10.69 64 215329 60476 110313430
Metastatic malignant melanoma 14.79 10.69 25 215368 3384 110370522
Diabetic ketoacidosis 14.73 10.69 38 215355 42020 110331886
Cytomegalovirus hepatitis 14.73 10.69 13 215380 893 110373013
Gastric ulcer 14.72 10.69 35 215358 39792 110334114
Urinary incontinence 14.67 10.69 152 215241 48435 110325471
Aplasia 14.66 10.69 41 215352 7832 110366074
Conjunctival hyperaemia 14.64 10.69 34 215359 5797 110368109
Tooth infection 14.64 10.69 13 215380 22203 110351703
Withdrawal syndrome 14.61 10.69 108 215285 31272 110342634
Osteochondrosis 14.43 10.69 21 215372 2500 110371406
Cardiac murmur 14.40 10.69 16 215377 24612 110349294
Decreased appetite 14.33 10.69 769 214624 475077 109898829
Hyperphosphataemia 14.29 10.69 7 215386 16374 110357532
Irregular sleep wake rhythm disorder 14.25 10.69 9 215384 370 110373536
Fanconi syndrome 14.21 10.69 25 215368 3494 110370412
Vertigo 14.18 10.69 243 215150 86627 110287279
Hyperchloraemia 14.16 10.69 15 215378 1291 110372615
Parasitic encephalitis 14.15 10.69 5 215388 52 110373854
Haemorrhagic transformation stroke 14.15 10.69 23 215370 3014 110370892
Teratoma 14.13 10.69 7 215386 178 110373728
Respiratory rate decreased 14.11 10.69 35 215358 6223 110367683
Twin pregnancy 14.10 10.69 13 215380 945 110372961
Violence-related symptom 14.09 10.69 13 215380 946 110372960
Musculoskeletal disorder 14.07 10.69 14 215379 22650 110351256
Karyotype analysis abnormal 14.06 10.69 5 215388 53 110373853
Hepatitis acute 14.05 10.69 73 215320 18693 110355213
Mixed anxiety and depressive disorder 14.03 10.69 11 215382 640 110373266
Talipes 13.99 10.69 7 215386 182 110373724
Conversion disorder 13.94 10.69 20 215373 2350 110371556
Pleuritic pain 13.92 10.69 7 215386 16133 110357773
Pulmonary oedema 13.92 10.69 127 215266 100532 110273374
Drug-induced liver injury 13.92 10.69 319 215074 119748 110254158
Biopsy skin 13.90 10.69 6 215387 110 110373796
Hypersexuality 13.88 10.69 18 215375 1922 110371984
Adverse drug reaction 13.82 10.69 135 215258 105424 110268482
Encephalocele 13.82 10.69 5 215388 56 110373850
Hyporesponsive to stimuli 13.79 10.69 22 215371 2838 110371068
Electrolyte imbalance 13.74 10.69 121 215272 36907 110336999
Diverticulum intestinal 13.74 10.69 3 215390 11716 110362190
Feeling drunk 13.73 10.69 32 215361 5468 110368438
Blood uric acid increased 13.71 10.69 13 215380 21516 110352390
Emphysema 13.71 10.69 11 215382 19745 110354161
Heart rate 13.69 10.69 8 215385 285 110373621
Acute myeloid leukaemia 13.68 10.69 34 215359 38076 110335830
Osteomyelitis 13.66 10.69 32 215361 36568 110337338
Epilepsy surgery 13.66 10.69 3 215390 3 110373903
Pyruvate kinase deficiency anaemia 13.66 10.69 3 215390 3 110373903
Antimitochondrial antibody 13.66 10.69 3 215390 3 110373903
Multiple congenital abnormalities 13.61 10.69 6 215387 116 110373790
Blood glucose increased 13.60 10.69 179 215214 132317 110241589
Needle issue 13.59 10.69 9 215384 17831 110356075
Pancreatic carcinoma 13.52 10.69 6 215387 14866 110359040
Blood urea increased 13.51 10.69 58 215335 54899 110319007
Cardio-respiratory arrest 13.50 10.69 308 215085 115528 110258378
Dropped head syndrome 13.44 10.69 10 215383 538 110373368
Thrombotic microangiopathy 13.39 10.69 100 215293 29049 110344857
Peritumoural oedema 13.38 10.69 4 215389 23 110373883
Hemiplegia 13.35 10.69 83 215310 22699 110351207
Anxiety disorder 13.33 10.69 30 215363 5010 110368896
Drug-device interaction 13.29 10.69 6 215387 123 110373783
Anticonvulsant drug level abnormal 13.29 10.69 5 215388 63 110373843
Nosocomial infection 13.27 10.69 23 215370 3176 110370730
Synovial cyst 13.25 10.69 3 215390 11427 110362479
Papilloedema 13.23 10.69 38 215355 7371 110366535
Haematoma 13.22 10.69 173 215220 58303 110315603
Lower gastrointestinal haemorrhage 13.20 10.69 10 215383 18476 110355430
Therapeutic product ineffective for unapproved indication 13.18 10.69 8 215385 306 110373600
Urge incontinence 13.17 10.69 15 215378 1400 110372506
Drug tolerance 13.14 10.69 8 215385 16577 110357329
Myopia 13.12 10.69 19 215374 2252 110371654
Tendonitis 13.12 10.69 19 215374 26064 110347842
Primary mediastinal large B-cell lymphoma recurrent 13.11 10.69 6 215387 127 110373779
Primary mediastinal large B-cell lymphoma 13.08 10.69 5 215388 66 110373840
IIIrd nerve disorder 13.07 10.69 7 215386 210 110373696
Facial spasm 13.04 10.69 12 215381 870 110373036
Intensive care unit delirium 13.01 10.69 5 215388 67 110373839
Liver function test increased 13.01 10.69 110 215283 88438 110285468
Apoptosis 12.98 10.69 11 215382 715 110373191
Drug dose omission by device 12.97 10.69 6 215387 14510 110359396
Thunderclap headache 12.97 10.69 10 215383 568 110373338
Skin burning sensation 12.96 10.69 14 215379 21811 110352095
Drug dose titration not performed 12.93 10.69 13 215380 1052 110372854
Hyponatraemic seizure 12.81 10.69 11 215382 728 110373178
Glaucoma 12.77 10.69 15 215378 22502 110351404
Impaired self-care 12.75 10.69 20 215373 2544 110371362
Hallucination, olfactory 12.73 10.69 10 215383 584 110373322
Muscle contracture 12.72 10.69 21 215372 2787 110371119
Facial pain 12.72 10.69 7 215386 15332 110358574
Varicella zoster virus infection 12.69 10.69 34 215359 6334 110367572
Retinitis viral 12.68 10.69 9 215384 450 110373456
COVID-19 pneumonia 12.67 10.69 34 215359 37109 110336797
Blood osmolarity decreased 12.64 10.69 15 215378 1463 110372443
Refusal of treatment by patient 12.64 10.69 44 215349 9450 110364456
Intervertebral disc degeneration 12.63 10.69 10 215383 18075 110355831
Tachycardia 12.62 10.69 551 214842 226094 110147812
Adverse reaction 12.62 10.69 24 215369 29570 110344336
Liver disorder 12.55 10.69 198 215195 142045 110231861
Abortion threatened 12.54 10.69 9 215384 458 110373448
Blood creatine phosphokinase 12.53 10.69 8 215385 335 110373571
Intracranial pressure increased 12.47 10.69 47 215346 10488 110363418
Disability 12.46 10.69 25 215368 30198 110343708
CSF shunt operation 12.45 10.69 3 215390 6 110373900
Congenital hydronephrosis 12.45 10.69 3 215390 6 110373900
Congenital renal cyst 12.45 10.69 3 215390 6 110373900
Gerstmann's syndrome 12.45 10.69 3 215390 6 110373900
Diastolic hypotension 12.43 10.69 8 215385 340 110373566
Aortic arteriosclerosis 12.42 10.69 3 215390 10935 110362971
Intracranial mass 12.39 10.69 19 215374 2369 110371537
Nocturia 12.37 10.69 9 215384 16981 110356925
Coma acidotic 12.31 10.69 6 215387 147 110373759
Device issue 12.25 10.69 31 215362 34504 110339402
Extensor plantar response 12.24 10.69 17 215376 1938 110371968
Acquired immunodeficiency syndrome 12.22 10.69 8 215385 350 110373556
Potentiating drug interaction 12.21 10.69 50 215343 11593 110362313
Kounis syndrome 12.18 10.69 32 215361 5893 110368013
Illogical thinking 12.15 10.69 5 215388 81 110373825
Neonatal seizure 12.14 10.69 4 215389 33 110373873
Urinary retention 12.13 10.69 197 215196 69486 110304420
Platelet count decreased 12.13 10.69 557 214836 229886 110144020
Temperature intolerance 12.11 10.69 6 215387 13944 110359962
Aphthous ulcer 12.07 10.69 14 215379 21122 110352784
Gastrostomy 12.07 10.69 15 215378 1535 110372371
Delusion of reference 12.02 10.69 7 215386 248 110373658
Hyperacusis 11.95 10.69 21 215372 2931 110370975
Post-traumatic epilepsy 11.93 10.69 4 215389 35 110373871
Gallbladder disorder 11.93 10.69 14 215379 21015 110352891
Joint injury 11.92 10.69 39 215354 39955 110333951
Infective pulmonary exacerbation of cystic fibrosis 11.88 10.69 7 215386 14764 110359142
Blood urine present 11.86 10.69 18 215375 24227 110349679
Chorea 11.81 10.69 22 215371 3213 110370693
Brugada syndrome 11.78 10.69 15 215378 1573 110372333
Dysphonia 11.76 10.69 93 215300 75836 110298070
Serotonin syndrome 11.75 10.69 171 215222 58982 110314924
Feeling cold 11.68 10.69 31 215362 33956 110339950
Cerebral venous thrombosis 11.68 10.69 22 215371 3240 110370666
Encephalitis viral 11.67 10.69 21 215372 2986 110370920
Trisomy 21 11.67 10.69 5 215388 90 110373816
Sexually inappropriate behaviour 11.66 10.69 10 215383 661 110373245
Body mass index decreased 11.64 10.69 11 215382 825 110373081
CSF virus identified 11.64 10.69 4 215389 38 110373868
Bronchiolitis 11.63 10.69 30 215363 5463 110368443
Large granular lymphocytosis 11.61 10.69 9 215384 515 110373391
B-lymphocyte count decreased 11.59 10.69 17 215376 2038 110371868
Pharyngeal oedema 11.58 10.69 9 215384 16419 110357487
Faciobrachial dystonic seizure 11.57 10.69 5 215388 92 110373814
Therapeutic response changed 11.56 10.69 15 215378 1603 110372303
Arteriosclerosis 11.54 10.69 19 215374 24748 110349158
Emotional disorder 11.51 10.69 62 215331 16098 110357808
Blood fibrinogen increased 11.51 10.69 17 215376 2051 110371855
Hyperfibrinogenaemia 11.49 10.69 6 215387 171 110373735
School refusal 11.46 10.69 4 215389 40 110373866
Cytomegalovirus gastritis 11.44 10.69 10 215383 678 110373228
Psychotic behaviour 11.43 10.69 14 215379 1411 110372495
Exomphalos 11.37 10.69 5 215388 96 110373810
Hyperpyrexia 11.27 10.69 38 215355 8031 110365875
Weight fluctuation 11.27 10.69 16 215377 22129 110351777
Delusional perception 11.25 10.69 8 215385 401 110373505
Platelet transfusion 11.21 10.69 20 215373 2826 110371080
Pyelonephritis 11.19 10.69 20 215373 25230 110348676
Joint dislocation 11.14 10.69 32 215361 34158 110339748
Eye irritation 11.13 10.69 31 215362 33421 110340485
Lymphogranuloma venereum 11.13 10.69 3 215390 11 110373895
Amniorrhexis 11.12 10.69 4 215389 44 110373862
Anticoagulation drug level decreased 11.10 10.69 7 215386 287 110373619
Agoraphobia 11.10 10.69 10 215383 706 110373200
Circadian rhythm sleep disorder 11.07 10.69 12 215381 1060 110372846
Toothache 11.06 10.69 18 215375 23557 110350349
Bacterial infection 11.06 10.69 49 215344 45987 110327919
Hernia 11.04 10.69 13 215380 19487 110354419
Magnetic resonance imaging abnormal 11.02 10.69 24 215369 3921 110369985
Abdominal compartment syndrome 10.95 10.69 16 215377 1911 110371995
Hyperlipasaemia 10.94 10.69 14 215379 1475 110372431
Craniofacial deformity 10.92 10.69 3 215390 12 110373894
Alcoholic seizure 10.92 10.69 3 215390 12 110373894
Threatened uterine rupture 10.92 10.69 3 215390 12 110373894
Product quality issue 10.92 10.69 97 215296 77202 110296704
Drug withdrawal headache 10.88 10.69 5 215388 107 110373799
Pathogen resistance 10.87 10.69 11 215382 17661 110356245
Maternal exposure timing unspecified 10.87 10.69 15 215378 20998 110352908
Carnitine deficiency 10.84 10.69 7 215386 299 110373607
Cerebral mass effect 10.84 10.69 18 215375 2401 110371505
Blood parathyroid hormone decreased 10.81 10.69 6 215387 13083 110360823
Peripheral ischaemia 10.80 10.69 4 215389 11054 110362852
Urinary tract stoma complication 10.79 10.69 5 215388 109 110373797
Polydactyly 10.79 10.69 5 215388 109 110373797
Muscle rigidity 10.79 10.69 82 215311 23949 110349957
Aortic stenosis 10.77 10.69 6 215387 13053 110360853
Apallic syndrome 10.77 10.69 12 215381 1094 110372812
Attention-seeking behaviour 10.75 10.69 5 215388 110 110373796
Pulmonary function test 10.73 10.69 3 215390 13 110373893
Superinfection 10.72 10.69 30 215363 5733 110368173
Amnestic disorder 10.70 10.69 10 215383 740 110373166

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 55.14 25.06 92 1629 1541 110691
Weight gain poor 42.16 25.06 22 1699 62 112170
Off label use 40.41 25.06 74 1647 1333 110899
Multiple-drug resistance 33.57 25.06 19 1702 66 112166
No adverse event 32.91 25.06 20 1701 82 112150
Cerebral cyst 29.03 25.06 12 1709 15 112217
Wrong dose 28.90 25.06 9 1712 0 112232
Gastrooesophageal reflux disease 28.20 25.06 12 1709 17 112215

Pharmacologic Action:

SourceCodeDescription
ATC N03AX14 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D018697 Nootropic Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

N03AX Other antiepileptics 18 drugs
beclamidebrivaracetamcannabidiolcarisbamatecenobamatefelbamatefenfluramineganaxolonelacosamidelamotrigineperampanelphenacemide show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Status epilepticus indication 230456007 DOID:1824
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Partial Epilepsy Treatment Adjunct indication
Tonic-Clonic Epilepsy Treatment Adjunct indication
Myoclonic Epilepsy Adjunct Treatment indication
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Mood swings contraindication 18963009
Ataxia contraindication 20262006
Indifference contraindication 20602000
Abnormal gait contraindication 22325002
Feeling agitated contraindication 24199005
Depressive disorder contraindication 35489007
Anxiety contraindication 48694002
Feeling irritable contraindication 55929007
Aggressive behavior contraindication 61372001
Psychotic disorder contraindication 69322001
Hostile behavior contraindication 79351003
Depersonalization contraindication 79499004
Fatigue contraindication 84229001
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Disease of liver contraindication 235856003 DOID:409
Drowsy contraindication 271782001
Neutropenic disorder contraindication 303011007 DOID:1227
Behavioral Disorders contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.66 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 DISCN TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Synaptic vesicle glycoprotein 2A Transporter MODULATOR Ki 6.10 CHEMBL CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.41 CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel WOMBAT-PK
Carbonic anhydrase 1 Enzyme Ki 5.10 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.28 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 7.05 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 7.27 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 5.04 CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel WOMBAT-PK
Carbonic anhydrase 7 Enzyme Ki 5.12 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.61 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 5.08 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.64 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 5.38 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 5.41 CHEMBL
Synaptic vesicle glycoprotein 2A Transporter INHIBITOR IC50 6.10 IUPHAR

External reference:

IDSource
D00709 KEGG_DRUG
4021198 VANDF
C0377265 UMLSCUI
CHEBI:6437 CHEBI
UKX PDB_CHEM_ID
CHEMBL1286 ChEMBL_ID
DB01202 DRUGBANK_ID
D000077287 MESH_DESCRIPTOR_UI
5284583 PUBCHEM_CID
6450 INN_ID
6826 IUPHAR_LIGAND_ID
44YRR34555 UNII
114477 RXNORM
31546 MMSL
66397 MMSL
8574 MMSL
d04499 MMSL
008058 NDDF
116076009 SNOMEDCT_US
387000003 SNOMEDCT_US
CHEMBL1400561 ChEMBL_ID
44YRR34555 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0799 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-1598 SOLUTION 1000 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-2397 SOLUTION 1500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-4799 SOLUTION 500 mg ORAL ANDA 27 sections
Levetiracetam in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9281 INJECTION 5 mg INTRAVENOUS ANDA 25 sections
Levetiracetam in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9282 INJECTION 10 mg INTRAVENOUS ANDA 25 sections
Levetiracetam in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9283 INJECTION 15 mg INTRAVENOUS ANDA 25 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9574 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9673 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0264-1009 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0264-1509 INJECTION 15 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0264-5009 INJECTION 5 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5615 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5615 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5617 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5617 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5619 TABLET, FILM COATED 1000 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5619 TABLET, FILM COATED 1000 mg ORAL ANDA 29 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 26 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-2011 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0472-0235 SOLUTION 100 mg ORAL ANDA 18 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8498 TABLET, FILM COATED 250 mg ORAL ANDA 23 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8499 TABLET, FILM COATED 500 mg ORAL ANDA 23 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8500 TABLET, FILM COATED 750 mg ORAL ANDA 23 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8501 TABLET, FILM COATED 1000 mg ORAL ANDA 23 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7123 TABLET, FILM COATED 250 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7124 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7125 TABLET, FILM COATED 750 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7265 SOLUTION 100 mg ORAL ANDA 30 sections
levetiracetam Human Prescription Drug Label 1 0904-7420 SOLUTION 100 mg ORAL ANDA 24 sections