Stem definition | Drug id | CAS RN |
---|---|---|
4310 | 175481-36-4 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.30 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 2 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 40 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 22.83 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.58 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.57 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 29, 2008 | EMA | ||
Oct. 28, 2008 | FDA | UCB INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1926.86 | 17.34 | 924 | 16331 | 122130 | 46546677 |
Status epilepticus | 1045.84 | 17.34 | 329 | 16926 | 13650 | 46655157 |
Epilepsy | 665.97 | 17.34 | 270 | 16985 | 23468 | 46645339 |
Generalised tonic-clonic seizure | 502.04 | 17.34 | 230 | 17025 | 26892 | 46641915 |
Multiple-drug resistance | 418.98 | 17.34 | 111 | 17144 | 2454 | 46666353 |
Off label use | 410.75 | 17.34 | 595 | 16660 | 379246 | 46289561 |
Overdose | 241.32 | 17.34 | 239 | 17016 | 101740 | 46567067 |
Partial seizures | 223.30 | 17.34 | 80 | 17175 | 4930 | 46663877 |
Focal dyscognitive seizures | 221.28 | 17.34 | 69 | 17186 | 2759 | 46666048 |
Diplopia | 173.57 | 17.34 | 101 | 17154 | 19304 | 46649503 |
Drug ineffective | 169.31 | 17.34 | 590 | 16665 | 677248 | 45991559 |
Pregnancy | 166.17 | 17.34 | 111 | 17144 | 27026 | 46641781 |
Petit mal epilepsy | 108.91 | 17.34 | 42 | 17213 | 3178 | 46665629 |
Electrocardiogram QRS complex prolonged | 99.98 | 17.34 | 46 | 17209 | 5403 | 46663404 |
Irritability | 93.82 | 17.34 | 81 | 17174 | 28865 | 46639942 |
Mitochondrial DNULL mutation | 87.57 | 17.34 | 20 | 17235 | 231 | 46668576 |
Aura | 85.00 | 17.34 | 26 | 17229 | 973 | 46667834 |
Propofol infusion syndrome | 78.00 | 17.34 | 23 | 17232 | 758 | 46668049 |
Drug ineffective for unapproved indication | 76.84 | 17.34 | 57 | 17198 | 16356 | 46652451 |
Pain | 76.01 | 17.34 | 41 | 17214 | 476907 | 46191900 |
Somnolence | 75.85 | 17.34 | 174 | 17081 | 156347 | 46512460 |
Atrioventricular block complete | 74.32 | 17.34 | 42 | 17213 | 7585 | 46661222 |
Seizure cluster | 72.07 | 17.34 | 16 | 17239 | 161 | 46668646 |
Drug interaction | 71.52 | 17.34 | 200 | 17055 | 202894 | 46465913 |
Sudden unexplained death in epilepsy | 69.30 | 17.34 | 17 | 17238 | 272 | 46668535 |
Maternal exposure during pregnancy | 68.38 | 17.34 | 130 | 17125 | 102419 | 46566388 |
Diarrhoea | 68.35 | 17.34 | 64 | 17191 | 559538 | 46109269 |
Maternal exposure before pregnancy | 67.42 | 17.34 | 33 | 17222 | 4448 | 46664359 |
Balance disorder | 67.37 | 17.34 | 100 | 17155 | 64421 | 46604386 |
Change in seizure presentation | 65.23 | 17.34 | 16 | 17239 | 256 | 46668551 |
Arthralgia | 64.69 | 17.34 | 27 | 17228 | 364576 | 46304231 |
Myoclonic epilepsy | 61.78 | 17.34 | 20 | 17235 | 903 | 46667904 |
Neurotoxicity | 60.56 | 17.34 | 46 | 17209 | 13671 | 46655136 |
Bradycardia | 59.74 | 17.34 | 96 | 17159 | 66202 | 46602605 |
Gene mutation | 58.69 | 17.34 | 20 | 17235 | 1060 | 46667747 |
Dyspnoea | 58.30 | 17.34 | 63 | 17192 | 515485 | 46153322 |
Abortion spontaneous | 58.03 | 17.34 | 76 | 17179 | 43570 | 46625237 |
Ataxia | 57.75 | 17.34 | 45 | 17210 | 13885 | 46654922 |
Electroencephalogram abnormal | 57.54 | 17.34 | 28 | 17227 | 3726 | 46665081 |
Premature delivery | 54.40 | 17.34 | 53 | 17202 | 22016 | 46646791 |
Atrioventricular block | 51.90 | 17.34 | 32 | 17223 | 6779 | 46662028 |
Encephalopathy | 51.82 | 17.34 | 63 | 17192 | 33526 | 46635281 |
Drug reaction with eosinophilia and systemic symptoms | 51.51 | 17.34 | 59 | 17196 | 29489 | 46639318 |
Electrocardiogram PR prolongation | 51.21 | 17.34 | 16 | 17239 | 643 | 46668164 |
No adverse event | 50.86 | 17.34 | 63 | 17192 | 34168 | 46634639 |
Angiofibroma | 49.61 | 17.34 | 11 | 17244 | 110 | 46668697 |
Blood gases abnormal | 47.53 | 17.34 | 15 | 17240 | 623 | 46668184 |
Drug resistance | 47.16 | 17.34 | 44 | 17211 | 17324 | 46651483 |
Myoclonus | 46.15 | 17.34 | 40 | 17215 | 14312 | 46654495 |
Psychotic disorder | 46.06 | 17.34 | 49 | 17206 | 22572 | 46646235 |
Abnormal behaviour | 45.34 | 17.34 | 47 | 17208 | 21011 | 46647796 |
Cardiac arrest | 43.17 | 17.34 | 100 | 17155 | 90299 | 46578508 |
Unmasking of previously unidentified disease | 41.54 | 17.34 | 14 | 17241 | 717 | 46668090 |
Aphasia | 41.51 | 17.34 | 52 | 17203 | 28515 | 46640292 |
Lymphangioleiomyomatosis | 40.31 | 17.34 | 10 | 17245 | 168 | 46668639 |
Pain in extremity | 39.99 | 17.34 | 23 | 17232 | 258657 | 46410150 |
Memory impairment | 39.64 | 17.34 | 88 | 17167 | 77249 | 46591558 |
Tonic convulsion | 39.46 | 17.34 | 15 | 17240 | 1091 | 46667716 |
Joint swelling | 39.27 | 17.34 | 7 | 17248 | 166066 | 46502741 |
Aggression | 38.94 | 17.34 | 45 | 17210 | 22699 | 46646108 |
Angiomyolipoma | 38.86 | 17.34 | 10 | 17245 | 196 | 46668611 |
Partial seizures with secondary generalisation | 38.71 | 17.34 | 11 | 17244 | 317 | 46668490 |
Laryngeal stenosis | 38.37 | 17.34 | 13 | 17242 | 677 | 46668130 |
Hyperammonaemic encephalopathy | 37.20 | 17.34 | 17 | 17238 | 1965 | 46666842 |
Dizziness | 36.73 | 17.34 | 233 | 17022 | 340181 | 46328626 |
Abdominal pain | 36.20 | 17.34 | 20 | 17235 | 230011 | 46438796 |
Atonic seizures | 35.73 | 17.34 | 12 | 17243 | 608 | 46668199 |
Cognitive disorder | 35.40 | 17.34 | 55 | 17200 | 36828 | 46631979 |
Back pain | 34.92 | 17.34 | 17 | 17238 | 210022 | 46458785 |
Respiratory acidosis | 34.86 | 17.34 | 24 | 17231 | 6124 | 46662683 |
Behaviour disorder | 34.24 | 17.34 | 16 | 17239 | 1945 | 46666862 |
Metabolic acidosis | 33.34 | 17.34 | 55 | 17200 | 38725 | 46630082 |
Tremor | 33.14 | 17.34 | 106 | 17149 | 115533 | 46553274 |
Cough | 32.12 | 17.34 | 23 | 17232 | 230226 | 46438581 |
Lipids abnormal | 31.14 | 17.34 | 9 | 17246 | 276 | 46668531 |
Sinus bradycardia | 30.10 | 17.34 | 31 | 17224 | 13751 | 46655056 |
Hallucination, visual | 29.99 | 17.34 | 35 | 17220 | 17838 | 46650969 |
Drug withdrawal convulsions | 29.97 | 17.34 | 13 | 17242 | 1328 | 46667479 |
Abortion induced | 29.81 | 17.34 | 27 | 17228 | 10233 | 46658574 |
Sinusitis | 29.54 | 17.34 | 6 | 17249 | 129762 | 46539045 |
Myalgia | 29.50 | 17.34 | 5 | 17250 | 123083 | 46545724 |
Stillbirth | 29.16 | 17.34 | 22 | 17233 | 6469 | 46662338 |
Injection site pain | 28.90 | 17.34 | 3 | 17252 | 107149 | 46561658 |
Disturbance in attention | 28.82 | 17.34 | 46 | 17209 | 31514 | 46637293 |
Simple partial seizures | 28.78 | 17.34 | 10 | 17245 | 562 | 46668245 |
Food interaction | 28.61 | 17.34 | 10 | 17245 | 572 | 46668235 |
Hyperammonaemia | 28.14 | 17.34 | 19 | 17236 | 4697 | 46664110 |
Dehydration | 27.93 | 17.34 | 12 | 17243 | 159528 | 46509279 |
Atrioventricular block first degree | 27.87 | 17.34 | 21 | 17234 | 6165 | 46662642 |
Anticonvulsant drug level decreased | 27.61 | 17.34 | 12 | 17243 | 1232 | 46667575 |
Suicide attempt | 27.49 | 17.34 | 62 | 17193 | 54974 | 46613833 |
Sinus node dysfunction | 27.33 | 17.34 | 18 | 17237 | 4271 | 46664536 |
Infusion related reaction | 26.87 | 17.34 | 3 | 17252 | 101205 | 46567602 |
Intrusive thoughts | 26.79 | 17.34 | 7 | 17248 | 146 | 46668661 |
Acute kidney injury | 26.35 | 17.34 | 29 | 17226 | 235826 | 46432981 |
Cardiotoxicity | 26.32 | 17.34 | 21 | 17234 | 6701 | 46662106 |
Anticonvulsant drug level increased | 26.08 | 17.34 | 12 | 17243 | 1408 | 46667399 |
Bronchitis | 26.08 | 17.34 | 4 | 17251 | 105975 | 46562832 |
Therapeutic product effective for unapproved indication | 26.06 | 17.34 | 6 | 17249 | 72 | 46668735 |
Encephalitis autoimmune | 25.46 | 17.34 | 11 | 17244 | 1113 | 46667694 |
Drug hypersensitivity | 25.08 | 17.34 | 32 | 17223 | 243793 | 46425014 |
Rhesus incompatibility | 25.07 | 17.34 | 6 | 17249 | 86 | 46668721 |
Nystagmus | 24.91 | 17.34 | 19 | 17236 | 5680 | 46663127 |
Anaemia | 24.86 | 17.34 | 35 | 17220 | 255744 | 46413063 |
Electrocardiogram ST segment elevation | 24.75 | 17.34 | 16 | 17239 | 3679 | 46665128 |
Therapeutic product ineffective for unapproved indication | 24.66 | 17.34 | 7 | 17248 | 201 | 46668606 |
Frontal lobe epilepsy | 24.37 | 17.34 | 4 | 17251 | 5 | 46668802 |
Electrocardiogram repolarisation abnormality | 24.21 | 17.34 | 11 | 17244 | 1254 | 46667553 |
Intensive care unit acquired weakness | 23.98 | 17.34 | 9 | 17246 | 632 | 46668175 |
Systolic dysfunction | 23.81 | 17.34 | 11 | 17244 | 1303 | 46667504 |
Nausea | 23.78 | 17.34 | 153 | 17102 | 687301 | 45981506 |
Maternal exposure during breast feeding | 23.56 | 17.34 | 14 | 17241 | 2775 | 46666032 |
Musculoskeletal stiffness | 23.44 | 17.34 | 4 | 17251 | 97989 | 46570818 |
Nasopharyngitis | 23.34 | 17.34 | 14 | 17241 | 153984 | 46514823 |
Suicidal ideation | 23.28 | 17.34 | 59 | 17196 | 56323 | 46612484 |
Peripheral swelling | 23.08 | 17.34 | 15 | 17240 | 158056 | 46510751 |
Blood lactic acid increased | 22.85 | 17.34 | 18 | 17237 | 5639 | 46663168 |
Directional Doppler flow tests abnormal | 22.61 | 17.34 | 4 | 17251 | 10 | 46668797 |
Swelling | 22.37 | 17.34 | 9 | 17246 | 124502 | 46544305 |
Intentional overdose | 21.84 | 17.34 | 63 | 17192 | 64881 | 46603926 |
Febrile infection-related epilepsy syndrome | 21.83 | 17.34 | 4 | 17251 | 13 | 46668794 |
Sedation | 21.75 | 17.34 | 34 | 17221 | 22876 | 46645931 |
Drug level increased | 21.29 | 17.34 | 30 | 17225 | 18411 | 46650396 |
Euthyroid sick syndrome | 21.21 | 17.34 | 5 | 17250 | 67 | 46668740 |
Ventricular hypokinesia | 20.98 | 17.34 | 15 | 17240 | 4063 | 46664744 |
Sinus arrest | 20.93 | 17.34 | 11 | 17244 | 1720 | 46667087 |
Amnesia | 20.90 | 17.34 | 47 | 17208 | 41584 | 46627223 |
Dysarthria | 20.72 | 17.34 | 44 | 17211 | 37454 | 46631353 |
Lipids | 20.29 | 17.34 | 4 | 17251 | 21 | 46668786 |
Head injury | 19.92 | 17.34 | 34 | 17221 | 24602 | 46644205 |
Violence-related symptom | 19.87 | 17.34 | 7 | 17248 | 410 | 46668397 |
Learning disorder | 19.67 | 17.34 | 7 | 17248 | 422 | 46668385 |
QRS axis abnormal | 19.66 | 17.34 | 9 | 17246 | 1044 | 46667763 |
Atrioventricular block second degree | 19.60 | 17.34 | 14 | 17241 | 3785 | 46665022 |
Tachycardia | 18.95 | 17.34 | 80 | 17175 | 99542 | 46569265 |
Chest discomfort | 18.90 | 17.34 | 5 | 17250 | 90264 | 46578543 |
Arthritis | 18.83 | 17.34 | 3 | 17252 | 77313 | 46591494 |
Ventricular fibrillation | 18.44 | 17.34 | 22 | 17233 | 11474 | 46657333 |
Prescribed overdose | 18.43 | 17.34 | 21 | 17234 | 10428 | 46658379 |
Arrhythmia | 18.24 | 17.34 | 40 | 17215 | 34801 | 46634006 |
Drug level decreased | 18.05 | 17.34 | 16 | 17239 | 5896 | 46662911 |
Intensive care unit delirium | 17.95 | 17.34 | 4 | 17251 | 41 | 46668766 |
Calcinosis | 17.93 | 17.34 | 10 | 17245 | 1759 | 46667048 |
Neonatal seizure | 17.77 | 17.34 | 6 | 17249 | 309 | 46668498 |
Malaise | 17.67 | 17.34 | 63 | 17192 | 331169 | 46337638 |
Asthma | 17.48 | 17.34 | 6 | 17249 | 91536 | 46577271 |
Shock | 17.47 | 17.34 | 30 | 17225 | 21815 | 46646992 |
Pneumonia aspiration | 17.36 | 17.34 | 37 | 17218 | 31568 | 46637239 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1611.70 | 17.78 | 813 | 12792 | 97662 | 29841211 |
Status epilepticus | 652.32 | 17.78 | 229 | 13376 | 10843 | 29928030 |
Generalised tonic-clonic seizure | 436.25 | 17.78 | 201 | 13404 | 19350 | 29919523 |
Epilepsy | 327.89 | 17.78 | 167 | 13438 | 20002 | 29918871 |
Off label use | 298.28 | 17.78 | 457 | 13148 | 248833 | 29690040 |
Partial seizures | 292.65 | 17.78 | 96 | 13509 | 3671 | 29935202 |
Multiple-drug resistance | 212.61 | 17.78 | 71 | 13534 | 2870 | 29936003 |
Drug ineffective | 170.43 | 17.78 | 433 | 13172 | 339954 | 29598919 |
Aggression | 145.35 | 17.78 | 126 | 13479 | 36781 | 29902092 |
Focal dyscognitive seizures | 141.62 | 17.78 | 43 | 13562 | 1270 | 29937603 |
Sudden unexplained death in epilepsy | 135.02 | 17.78 | 33 | 13572 | 417 | 29938456 |
Overdose | 106.14 | 17.78 | 159 | 13446 | 84178 | 29854695 |
Somnolence | 95.11 | 17.78 | 163 | 13442 | 96600 | 29842273 |
Petit mal epilepsy | 81.07 | 17.78 | 34 | 13571 | 2597 | 29936276 |
Partial seizures with secondary generalisation | 80.06 | 17.78 | 19 | 13586 | 210 | 29938663 |
Drug withdrawal convulsions | 68.22 | 17.78 | 24 | 13581 | 1135 | 29937738 |
Aura | 65.20 | 17.78 | 17 | 13588 | 283 | 29938590 |
Foetal exposure during pregnancy | 62.00 | 17.78 | 80 | 13525 | 36791 | 29902082 |
Necrosis ischaemic | 59.11 | 17.78 | 15 | 13590 | 223 | 29938650 |
Behaviour disorder | 57.46 | 17.78 | 26 | 13579 | 2386 | 29936487 |
Cognitive disorder | 57.44 | 17.78 | 62 | 13543 | 23628 | 29915245 |
Dyspnoea | 55.98 | 17.78 | 42 | 13563 | 333253 | 29605620 |
Ataxia | 55.17 | 17.78 | 44 | 13561 | 11418 | 29927455 |
Drug resistance | 54.71 | 17.78 | 56 | 13549 | 20077 | 29918796 |
Nystagmus | 53.69 | 17.78 | 30 | 13575 | 4308 | 29934565 |
Atrioventricular block complete | 52.89 | 17.78 | 38 | 13567 | 8439 | 29930434 |
Seizure cluster | 52.12 | 17.78 | 12 | 13593 | 115 | 29938758 |
Hyperammonaemia | 49.50 | 17.78 | 31 | 13574 | 5489 | 29933384 |
No adverse event | 48.32 | 17.78 | 49 | 13556 | 17370 | 29921503 |
Atrioventricular block second degree | 48.04 | 17.78 | 25 | 13580 | 3115 | 29935758 |
Congenital hypoplasia of depressor angularis oris muscle | 48.04 | 17.78 | 8 | 13597 | 8 | 29938865 |
Superinfection | 46.87 | 17.78 | 20 | 13585 | 1594 | 29937279 |
Maternal exposure during pregnancy | 45.82 | 17.78 | 26 | 13579 | 3845 | 29935028 |
Atrioventricular block | 43.96 | 17.78 | 32 | 13573 | 7250 | 29931623 |
Brain operation | 41.96 | 17.78 | 12 | 13593 | 286 | 29938587 |
Exposure via breast milk | 40.82 | 17.78 | 18 | 13587 | 1554 | 29937319 |
Myoclonic epilepsy | 40.71 | 17.78 | 15 | 13590 | 811 | 29938062 |
Irritability | 40.28 | 17.78 | 51 | 13554 | 22999 | 29915874 |
Mucosal ulceration | 39.82 | 17.78 | 15 | 13590 | 863 | 29938010 |
Postictal psychosis | 38.13 | 17.78 | 9 | 13596 | 97 | 29938776 |
Intestinal ischaemia | 36.48 | 17.78 | 28 | 13577 | 6869 | 29932004 |
Coarctation of the aorta | 36.39 | 17.78 | 12 | 13593 | 465 | 29938408 |
Diarrhoea | 36.39 | 17.78 | 60 | 13545 | 334043 | 29604830 |
Acoustic stimulation tests abnormal | 35.40 | 17.78 | 8 | 13597 | 70 | 29938803 |
Bradycardia | 33.03 | 17.78 | 84 | 13521 | 65442 | 29873431 |
Haemoglobin decreased | 32.97 | 17.78 | 6 | 13599 | 114092 | 29824781 |
Drug ineffective for unapproved indication | 32.74 | 17.78 | 32 | 13573 | 10848 | 29928025 |
Agitation | 32.27 | 17.78 | 74 | 13531 | 53999 | 29884874 |
Pain | 31.22 | 17.78 | 20 | 13585 | 172621 | 29766252 |
Encephalopathy | 31.21 | 17.78 | 54 | 13551 | 32151 | 29906722 |
Premature baby | 30.87 | 17.78 | 38 | 13567 | 16653 | 29922220 |
Anomaly of external ear congenital | 30.80 | 17.78 | 8 | 13597 | 131 | 29938742 |
Depressive symptom | 30.75 | 17.78 | 15 | 13590 | 1630 | 29937243 |
Drug interaction | 29.71 | 17.78 | 173 | 13432 | 199395 | 29739478 |
Low birth weight baby | 28.54 | 17.78 | 23 | 13582 | 6053 | 29932820 |
Hippocampal sclerosis | 28.45 | 17.78 | 7 | 13598 | 91 | 29938782 |
Diplopia | 28.16 | 17.78 | 33 | 13572 | 13739 | 29925134 |
Febrile neutropenia | 27.98 | 17.78 | 7 | 13598 | 106686 | 29832187 |
Dizziness | 27.74 | 17.78 | 167 | 13438 | 194742 | 29744131 |
Atrial septal defect | 26.57 | 17.78 | 23 | 13582 | 6678 | 29932195 |
Change in seizure presentation | 26.50 | 17.78 | 6 | 13599 | 53 | 29938820 |
Intellectual disability | 26.39 | 17.78 | 11 | 13594 | 827 | 29938046 |
Congenital melanocytic naevus | 26.09 | 17.78 | 5 | 13600 | 17 | 29938856 |
Glioblastoma | 25.80 | 17.78 | 12 | 13593 | 1173 | 29937700 |
Arthralgia | 24.17 | 17.78 | 16 | 13589 | 135775 | 29803098 |
Pneumonia | 24.16 | 17.78 | 75 | 13530 | 334231 | 29604642 |
Abdominal pain | 24.12 | 17.78 | 16 | 13589 | 135638 | 29803235 |
Pneumonia aspiration | 23.98 | 17.78 | 53 | 13552 | 37727 | 29901146 |
Acute kidney injury | 23.87 | 17.78 | 56 | 13549 | 273786 | 29665087 |
Psychotic disorder | 23.41 | 17.78 | 38 | 13567 | 21477 | 29917396 |
Dissociation | 23.17 | 17.78 | 11 | 13594 | 1126 | 29937747 |
Systemic inflammatory response syndrome | 23.04 | 17.78 | 21 | 13584 | 6525 | 29932348 |
Unmasking of previously unidentified disease | 22.78 | 17.78 | 9 | 13596 | 589 | 29938284 |
Speech disorder | 22.32 | 17.78 | 40 | 13565 | 24472 | 29914401 |
Anger | 21.67 | 17.78 | 26 | 13579 | 11094 | 29927779 |
Memory impairment | 21.21 | 17.78 | 50 | 13555 | 37124 | 29901749 |
Brain oedema | 20.97 | 17.78 | 27 | 13578 | 12371 | 29926502 |
Gastrointestinal haemorrhage | 20.88 | 17.78 | 6 | 13599 | 83440 | 29855433 |
Hyperammonaemic encephalopathy | 20.79 | 17.78 | 12 | 13593 | 1832 | 29937041 |
Psychogenic seizure | 20.78 | 17.78 | 7 | 13598 | 290 | 29938583 |
Haematuria traumatic | 20.23 | 17.78 | 6 | 13599 | 163 | 29938710 |
Abnormal behaviour | 19.83 | 17.78 | 39 | 13566 | 25584 | 29913289 |
Renal failure | 19.40 | 17.78 | 18 | 13587 | 128948 | 29809925 |
Hyperkinesia | 19.36 | 17.78 | 12 | 13593 | 2086 | 29936787 |
Drug reaction with eosinophilia and systemic symptoms | 19.25 | 17.78 | 41 | 13564 | 28447 | 29910426 |
Drug level decreased | 19.22 | 17.78 | 18 | 13587 | 5787 | 29933086 |
Blood lactic acid increased | 19.15 | 17.78 | 18 | 13587 | 5812 | 29933061 |
Bradycardia neonatal | 19.09 | 17.78 | 9 | 13596 | 907 | 29937966 |
Bradykinesia | 19.05 | 17.78 | 14 | 13591 | 3216 | 29935657 |
Periventricular haemorrhage neonatal | 19.02 | 17.78 | 4 | 13601 | 24 | 29938849 |
Suicidal ideation | 18.91 | 17.78 | 47 | 13558 | 36067 | 29902806 |
Hypothermia neonatal | 18.60 | 17.78 | 5 | 13600 | 94 | 29938779 |
Brain neoplasm | 18.59 | 17.78 | 13 | 13592 | 2764 | 29936109 |
Anaemia | 18.53 | 17.78 | 42 | 13563 | 207950 | 29730923 |
Congenital aortic atresia | 18.49 | 17.78 | 4 | 13601 | 28 | 29938845 |
Chills | 18.47 | 17.78 | 5 | 13600 | 72333 | 29866540 |
Product availability issue | 18.09 | 17.78 | 8 | 13597 | 695 | 29938178 |
Myoclonus | 17.99 | 17.78 | 26 | 13579 | 13286 | 29925587 |
Thoracic vertebral fracture | 17.93 | 17.78 | 10 | 13595 | 1430 | 29937443 |
Source | Code | Description |
---|---|---|
ATC | N03AX18 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Other antiepileptics |
FDA PE | N0000008486 | Decreased Central Nervous System Disorganized Electrical Activity |
FDA EPC | N0000175753 | Anti-epileptic Agent |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D026941 | Sodium Channel Blockers |
MeSH PA | D061567 | Voltage-Gated Sodium Channel Blockers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Partial Epilepsy Treatment Adjunct | indication | ||
Atrial flutter | contraindication | 5370000 | |
Suicidal thoughts | contraindication | 6471006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Orthostatic hypotension | contraindication | 28651003 | |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Chronic heart failure | contraindication | 48447003 | |
Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
Acute nephropathy | contraindication | 58574008 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Suicidal | contraindication | 267073005 | |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Severe Cardiac Disease | contraindication | ||
First Degree Atrioventricular Heart Block | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.83 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha | Ion channel | BLOCKER | IC50 | 6.74 | CHEMBL | CHEMBL | |||
Carbonic anhydrase 2 | Enzyme | Ki | 6.48 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 5.43 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 6.28 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 5.92 | CHEMBL | |||||
Carbonic anhydrase 3 | Enzyme | Ki | 6.43 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.34 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 6.33 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 5.35 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 6.45 | CHEMBL | |||||
Carbonic anhydrase 1 | Enzyme | Ki | 6.44 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 6.47 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 6.39 | CHEMBL | |||||
Dihydropyrimidinase-related protein 2 | Unclassified | WOMBAT-PK | |||||||
Sodium channel protein type X alpha subunit | Unclassified | IC50 | 4.80 | CHEMBL | |||||
Sodium channel protein type 3 subunit alpha | Ion channel | IC50 | 6.38 | CHEMBL | |||||
Carbonic anhydrase 15 | Enzyme | Ki | 6.34 | CHEMBL | |||||
Sodium channel protein type 2 subunit alpha | Ion channel | BLOCKER | IC50 | 4.52 | IUPHAR |
ID | Source |
---|---|
4028103 | VUID |
N0000179735 | NUI |
D07299 | KEGG_DRUG |
4028103 | VANDF |
C0893761 | UMLSCUI |
CHEBI:135939 | CHEBI |
CHEMBL58323 | ChEMBL_ID |
DB06218 | DRUGBANK_ID |
D000078334 | MESH_DESCRIPTOR_UI |
C476828 | MESH_SUPPLEMENTAL_RECORD_UI |
219078 | PUBCHEM_CID |
7472 | IUPHAR_LIGAND_ID |
8094 | INN_ID |
563KS2PQY5 | UNII |
623400 | RXNORM |
158490 | MMSL |
25914 | MMSL |
d07349 | MMSL |
012839 | NDDF |
441532003 | SNOMEDCT_US |
441647003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0131-1810 | INJECTION | 10 mg | INTRAVENOUS | NDA | 36 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0131-2477 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 36 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0131-2478 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 36 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0131-2479 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 36 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0131-2480 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 36 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0131-5410 | SOLUTION | 10 mg | ORAL | NDA | 36 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6077 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 32 sections |
Lacosamide | Human Prescription Drug Label | 1 | 63850-0053 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Lacosamide | Human Prescription Drug Label | 1 | 63850-0054 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 31 sections |
Lacosamide | Human Prescription Drug Label | 1 | 63850-0055 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 31 sections |
Lacosamide | Human Prescription Drug Label | 1 | 63850-0056 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 31 sections |
Lacosamide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65162-912 | SOLUTION | 10 mg | ORAL | ANDA | 20 sections |
Vimpat | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70166-617 | SOLUTION | 10 mg | ORAL | NDA | 34 sections |