lamotrigine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1540 84057-84-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lamictal
  • lamotrigine
  • lamitrin
  • lamotrigin
  • BW 430C
A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
  • Molecular weight: 256.09
  • Formula: C9H7Cl2N5
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 90.71
  • ALOGS: -2.72
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.17 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 27.89 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97.60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 27, 1994 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2814.57 10.76 2282 122894 122837 56044054
Drug reaction with eosinophilia and systemic symptoms 1907.41 10.76 1051 124125 29253 56137638
Epilepsy 1386.88 10.76 801 124375 24430 56142461
Stevens-Johnson syndrome 1354.61 10.76 760 124416 21903 56144988
Completed suicide 1350.15 10.76 1573 123603 132260 56034631
Exposure during pregnancy 1151.38 10.76 1465 123711 134877 56032014
Intentional overdose 1036.04 10.76 997 124179 67120 56099771
Toxicity to various agents 1003.83 10.76 1792 123384 222772 55944119
Product substitution issue 808.67 10.76 466 124710 14133 56152758
Generalised tonic-clonic seizure 774.56 10.76 575 124601 26991 56139900
Rheumatoid arthritis 679.08 10.76 44 125132 382560 55784331
Abortion spontaneous 632.20 10.76 623 124553 43130 56123761
Toxic epidermal necrolysis 604.04 10.76 453 124723 21589 56145302
Suicide attempt 590.61 10.76 685 124491 57151 56109740
Drug interaction 569.33 10.76 1364 123812 208391 55958500
Intentional self-injury 461.44 10.76 408 124768 24584 56142307
Overdose 449.11 10.76 827 124349 105003 56061888
Foetal exposure during pregnancy 436.18 10.76 453 124723 33370 56133521
Suicidal ideation 402.80 10.76 566 124610 57176 56109715
Somnolence 387.54 10.76 1010 124166 162403 56004488
Joint swelling 370.68 10.76 94 125082 289706 55877185
Status epilepticus 355.52 10.76 284 124892 14857 56152034
Contraindicated product administered 343.59 10.76 17 125159 186269 55980622
Petit mal epilepsy 343.33 10.76 165 125011 3413 56163478
Arthralgia 339.46 10.76 370 124806 501299 55665592
Pain 337.32 10.76 601 124575 662583 55504308
Nystagmus 330.68 10.76 189 124987 5636 56161255
Infusion related reaction 324.78 10.76 41 125135 208890 55958001
Synovitis 324.63 10.76 7 125169 161298 56005593
Arthropathy 324.56 10.76 34 125142 200241 55966650
Drug level increased 323.44 10.76 308 124868 20417 56146474
Aggression 307.81 10.76 308 124868 21698 56145193
Tremor 297.78 10.76 759 124417 120330 56046561
Ataxia 295.93 10.76 250 124926 14153 56152738
Mania 294.02 10.76 227 124949 11293 56155598
Rash maculo-papular 292.59 10.76 341 124835 28566 56138325
Diarrhoea 286.20 10.76 623 124553 637884 55529007
Lymphadenopathy 283.27 10.76 370 124806 34838 56132053
Hand deformity 282.61 10.76 3 125173 134489 56032402
Agitation 276.39 10.76 468 124708 55568 56111323
Dyspnoea 263.94 10.76 580 124596 591997 55574894
Peripheral swelling 260.76 10.76 98 125078 234628 55932263
Drug eruption 257.55 10.76 302 124874 25461 56141430
Abdominal discomfort 248.41 10.76 155 125021 277119 55889772
Focal dyscognitive seizures 246.23 10.76 122 125054 2703 56164188
Swelling 242.48 10.76 115 125061 239656 55927235
Depression 234.27 10.76 905 124271 179212 55987679
Pneumonia 229.68 10.76 344 124832 406754 55760137
Partial seizures 228.54 10.76 145 125031 5245 56161646
Bipolar disorder 228.35 10.76 165 125011 7415 56159476
Oral mucosa erosion 222.62 10.76 86 125090 1014 56165877
Irritability 218.16 10.76 298 124878 29290 56137601
Diplopia 214.03 10.76 245 124931 20124 56146767
Serotonin syndrome 214.02 10.76 279 124897 26211 56140680
Glossodynia 209.66 10.76 42 125134 152416 56014475
Coma 207.53 10.76 429 124747 59226 56107665
Nasopharyngitis 202.74 10.76 120 125056 220839 55946052
Systemic lupus erythematosus 200.23 10.76 75 125101 180003 55986888
Disturbance in attention 199.21 10.76 300 124876 32240 56134651
Sudden unexplained death in epilepsy 197.43 10.76 58 125118 265 56166626
Multiple-drug resistance 183.86 10.76 113 125063 3861 56163030
Drug intolerance 182.33 10.76 192 124984 264626 55902265
Alopecia 180.31 10.76 233 124943 293225 55873666
Pain in extremity 174.78 10.76 244 124932 297187 55869704
Atrial septal defect 174.36 10.76 132 125044 6374 56160517
Anxiety 174.33 10.76 870 124306 192302 55974589
Lip erosion 174.21 10.76 68 125108 826 56166065
Wound 173.47 10.76 47 125129 138757 56028134
Discomfort 169.80 10.76 52 125124 141709 56025182
Myoclonic epilepsy 167.38 10.76 71 125105 1082 56165809
Abortion induced 165.22 10.76 151 125025 9494 56157397
Erythema multiforme 162.54 10.76 149 125027 9405 56157486
Myoclonus 159.95 10.76 183 124993 15020 56151871
Abnormal behaviour 158.31 10.76 210 124966 20062 56146829
Infection 154.34 10.76 131 125045 200075 55966816
Lower respiratory tract infection 152.92 10.76 34 125142 114760 56052131
Anticonvulsant drug level decreased 152.67 10.76 67 125109 1114 56165777
Rash 152.03 10.76 1719 123457 491328 55675563
Maternal exposure during breast feeding 151.86 10.76 97 125079 3550 56163341
Poisoning 151.61 10.76 164 125012 12649 56154242
Conjunctival hyperaemia 150.72 10.76 81 125095 2135 56164756
Psychotic disorder 149.64 10.76 221 124955 23337 56143554
Fatigue 145.14 10.76 1094 124082 787458 55379433
Haemophagocytic lymphohistiocytosis 143.17 10.76 139 125037 9433 56157458
Hyperreflexia 141.76 10.76 107 125069 5143 56161748
Anaemia 141.20 10.76 236 124940 267275 55899616
Ventricular septal defect 140.70 10.76 97 125079 4041 56162850
Sinusitis 139.60 10.76 140 125036 197441 55969450
Selective eating disorder 136.27 10.76 72 125104 1832 56165059
Clonus 133.74 10.76 95 125081 4154 56162737
Therapeutic product effect decreased 131.66 10.76 110 125066 169342 55997549
Rash morbilliform 127.75 10.76 81 125095 2926 56163965
Obsessive-compulsive disorder 126.31 10.76 87 125089 3619 56163272
Aura 125.47 10.76 56 125120 971 56165920
Extrapyramidal disorder 123.73 10.76 145 125031 12211 56154680
Hyperthermia 123.33 10.76 120 125056 8165 56158726
Tardive dyskinesia 120.82 10.76 117 125059 7914 56158977
Pericarditis 118.30 10.76 47 125129 108876 56058015
Atrial fibrillation 116.62 10.76 48 125128 108849 56058042
Disease progression 114.85 10.76 45 125131 105128 56061763
Suicidal behaviour 114.64 10.76 70 125106 2363 56164528
Face oedema 114.17 10.76 171 125005 18281 56148610
Pleurothotonus 112.03 10.76 56 125120 1265 56165626
Back pain 111.95 10.76 224 124952 236946 55929945
Toxic skin eruption 111.34 10.76 134 125042 11605 56155286
Impaired healing 111.15 10.76 28 125148 86813 56080078
Muscle rigidity 109.81 10.76 127 125049 10544 56156347
Electrocardiogram QRS complex prolonged 108.41 10.76 93 125083 5374 56161517
Anticonvulsant drug level increased 108.16 10.76 56 125120 1365 56165526
Pregnancy 106.08 10.76 230 124946 32803 56134088
Maternal drugs affecting foetus 105.83 10.76 89 125087 5004 56161887
Neuroleptic malignant syndrome 105.57 10.76 129 125047 11349 56155542
Cough 105.22 10.76 267 124909 259694 55907197
Intentional product use issue 105.13 10.76 45 125131 99688 56067203
Cross sensitivity reaction 105.11 10.76 62 125114 1963 56164928
Drug level decreased 104.56 10.76 102 125074 6962 56159929
Bipolar I disorder 104.49 10.76 58 125118 1632 56165259
Meningitis aseptic 104.28 10.76 83 125093 4316 56162575
Depressed level of consciousness 103.32 10.76 318 124858 56115 56110776
Muscle injury 102.81 10.76 3 125173 52497 56114394
Mobility decreased 102.23 10.76 46 125130 98945 56067946
Folliculitis 101.33 10.76 5 125171 54974 56111917
Exposure via breast milk 100.72 10.76 58 125118 1754 56165137
Cognitive disorder 100.53 10.76 288 124888 48845 56118046
Irritable bowel syndrome 100.26 10.76 16 125160 68442 56098449
Eosinophilia 96.70 10.76 166 125010 19911 56146980
Hypertension 96.46 10.76 254 124922 244024 55922867
Infarction 96.19 10.76 63 125113 2408 56164483
Anticonvulsant drug level above therapeutic 95.59 10.76 38 125138 486 56166405
Cardio-respiratory arrest 95.09 10.76 305 124871 55016 56111875
Cardiac failure congestive 95.00 10.76 38 125138 87682 56079209
Hypersensitivity 95 10.76 275 124901 256133 55910758
Cardiac arrest 94.84 10.76 412 124764 85902 56080989
Product use issue 94.54 10.76 168 125008 185873 55981018
Anger 94.36 10.76 123 125053 11549 56155342
Febrile neutropenia 94.36 10.76 59 125117 105486 56061405
Caesarean section 93.73 10.76 145 125031 15946 56150945
Malignant neoplasm progression 93.64 10.76 24 125152 73563 56093328
Depressed mood 92.45 10.76 231 124945 36128 56130763
Mood altered 91.68 10.76 130 125046 13225 56153666
Stillbirth 90.62 10.76 89 125087 6125 56160766
Vertigo 89.41 10.76 296 124880 54276 56112615
Dizziness 88.92 10.76 1249 123927 374891 55792000
Electroencephalogram abnormal 88.69 10.76 69 125107 3470 56163421
Camptocormia 88.57 10.76 31 125145 270 56166621
Dyskinesia 88.18 10.76 198 124978 28910 56137981
Chest pain 88.04 10.76 181 124995 189616 55977275
Death 87.50 10.76 426 124750 341000 55825891
Mood swings 86.69 10.76 143 125033 16604 56150287
Treatment failure 86.45 10.76 154 125022 170238 55996653
Electrocardiogram QT prolonged 85.81 10.76 292 124884 54296 56112595
Unresponsive to stimuli 85.37 10.76 206 124970 31519 56135372
Arthritis 84.95 10.76 59 125117 99793 56067098
Suspected suicide 84.81 10.76 81 125095 5385 56161506
Delusion 84.23 10.76 114 125062 11101 56155790
Gastrointestinal haemorrhage 83.73 10.76 32 125144 75919 56090972
Hypogammaglobulinaemia 82.67 10.76 86 125090 6340 56160551
Akathisia 82.44 10.76 99 125077 8553 56158338
Sedation 81.95 10.76 215 124961 34639 56132252
Gastrointestinal disorder 81.69 10.76 78 125098 112624 56054267
Plasma cell myeloma 80.66 10.76 6 125170 46640 56120251
Hypomania 80.57 10.76 75 125101 4827 56162064
Blepharospasm 80.31 10.76 64 125112 3334 56163557
Partial seizures with secondary generalisation 79.75 10.76 31 125145 372 56166519
Musculoskeletal pain 78.78 10.76 41 125135 81111 56085780
Blood pressure increased 77.50 10.76 127 125049 145049 56021842
Therapeutic response unexpected 76.99 10.76 137 125039 16907 56149984
Sleep disorder due to general medical condition, insomnia type 76.61 10.76 5 125171 43333 56123558
Rash macular 76.15 10.76 152 125024 20452 56146439
Pyrexia 75.92 10.76 1330 123846 417443 55749448
Affective disorder 75.72 10.76 77 125099 5526 56161365
Neuropathy peripheral 74.82 10.76 71 125105 102822 56064069
Behaviour disorder 74.82 10.76 56 125120 2657 56164234
Hallucination, auditory 74.46 10.76 109 125067 11415 56155476
Rash papular 72.97 10.76 117 125059 13266 56153625
Respiratory arrest 71.06 10.76 188 124988 30437 56136454
Psychomotor retardation 69.89 10.76 61 125115 3608 56163283
Bronchitis 69.02 10.76 89 125087 112222 56054669
Musculoskeletal stiffness 68.81 10.76 153 125023 155854 56011037
Haemoglobin decreased 68.23 10.76 121 125055 134016 56032875
Psoriatic arthropathy 68.05 10.76 40 125136 73968 56092923
Psychomotor hyperactivity 68.01 10.76 96 125080 9724 56157167
Small for dates baby 67.87 10.76 59 125117 3471 56163420
Memory impairment 67.72 10.76 375 124801 86182 56080709
Drug abuse 67.70 10.76 314 124862 67296 56099595
Muscle twitching 67.59 10.76 126 125050 16116 56150775
Osteoarthritis 67.56 10.76 48 125128 80248 56086643
Atonic seizures 66.50 10.76 31 125145 597 56166294
Mental impairment 66.34 10.76 109 125067 12613 56154278
Hepatic enzyme increased 66.25 10.76 180 124996 171204 55995687
General physical health deterioration 66.13 10.76 178 124998 169832 55997059
Altered state of consciousness 65.75 10.76 153 125023 22868 56144023
Rash erythematous 64.67 10.76 206 124970 37015 56129876
Talipes 64.16 10.76 40 125136 1402 56165489
Inappropriate antidiuretic hormone secretion 63.98 10.76 112 125064 13644 56153247
Eosinophilic myocarditis 63.74 10.76 26 125150 357 56166534
Chronic obstructive pulmonary disease 63.60 10.76 24 125152 57391 56109500
Temporal lobe epilepsy 63.54 10.76 26 125150 360 56166531
Mental disorder 63.22 10.76 153 125023 23451 56143440
C-reactive protein abnormal 62.90 10.76 5 125171 36804 56130087
Epileptic aura 62.70 10.76 17 125159 54 56166837
Hyperkalaemia 62.06 10.76 18 125158 50847 56116044
Tachycardia 61.02 10.76 424 124752 105452 56061439
Herpes zoster 60.46 10.76 48 125128 75841 56091050
Restlessness 60.46 10.76 162 125014 26424 56140467
Inappropriate affect 60.46 10.76 32 125144 817 56166074
Cardiac failure 60.44 10.76 56 125120 82037 56084854
Sopor 59.69 10.76 139 125037 20783 56146108
Dysmorphism 59.52 10.76 45 125131 2168 56164723
Enanthema 59.35 10.76 25 125151 374 56166517
Therapeutic response changed 59.28 10.76 32 125144 851 56166040
Acute kidney injury 58.98 10.76 305 124871 240458 55926433
Hip arthroplasty 58.92 10.76 8 125168 38615 56128276
Cheilitis 58.91 10.76 56 125120 3701 56163190
Cerebellar syndrome 58.83 10.76 54 125122 3413 56163478
Tic 58.43 10.76 36 125140 1235 56165656
Patent ductus arteriosus 58.38 10.76 57 125119 3894 56162997
Drug clearance increased 58.35 10.76 17 125159 75 56166816
Asthma 58.01 10.76 101 125075 112669 56054222
Dyspnoea exertional 57.10 10.76 25 125151 54664 56112227
Trichiasis 56.98 10.76 16 125160 60 56166831
Neovascularisation 56.77 10.76 33 125143 1016 56165875
Balance disorder 56.21 10.76 326 124850 76194 56090697
Accidental exposure to product by child 55.91 10.76 34 125142 1139 56165752
Pregnancy on oral contraceptive 55.89 10.76 32 125144 957 56165934
Speech disorder 55.82 10.76 197 124979 37296 56129595
Loss of consciousness 55.04 10.76 424 124752 108925 56057966
Hallucination 55.03 10.76 236 124940 48913 56117978
Dystonia 55.02 10.76 99 125077 12322 56154569
Injection site erythema 54.50 10.76 55 125121 77393 56089498
Papule 54.45 10.76 59 125117 4558 56162333
Congenital choroid plexus cyst 53.87 10.76 22 125154 303 56166588
Cerebrovascular accident 53.75 10.76 86 125090 99184 56067707
Foetal anticonvulsant syndrome 53.73 10.76 26 125150 546 56166345
Oculomucocutaneous syndrome 53.48 10.76 17 125159 106 56166785
Knee arthroplasty 53.38 10.76 16 125160 44243 56122648
Oculogyric crisis 52.46 10.76 36 125140 1488 56165403
Unintended pregnancy 52.11 10.76 61 125115 5130 56161761
Brugada syndrome 51.82 10.76 22 125154 336 56166555
Myocardial infarction 51.67 10.76 79 125097 92791 56074100
Maternal exposure during pregnancy 51.53 10.76 646 124530 188907 55977984
Coordination abnormal 51.38 10.76 97 125079 12524 56154367
Diverticulitis 51.11 10.76 9 125167 35843 56131048
Skin degenerative disorder 51.11 10.76 10 125166 0 56166891
Blood pressure systolic increased 50.66 10.76 14 125162 40822 56126069
Coronary artery disease 50.41 10.76 5 125171 30791 56136100
Gestational diabetes 50.26 10.76 75 125101 7989 56158902
Thinking abnormal 50.26 10.76 84 125092 9857 56157034
Poisoning deliberate 50.19 10.76 84 125092 9869 56157022
Fluid retention 50.04 10.76 29 125147 54049 56112842
Human herpesvirus 6 infection 49.90 10.76 44 125132 2638 56164253
Hypertonia 49.50 10.76 53 125123 4039 56162852
Pain in jaw 49.15 10.76 14 125162 40022 56126869
Wheezing 48.67 10.76 57 125119 74969 56091922
Euphoric mood 48.46 10.76 54 125122 4304 56162587
Fibromyalgia 48.37 10.76 37 125139 59566 56107325
Impulsive behaviour 48.14 10.76 34 125142 1473 56165418
Premature baby 47.75 10.76 121 125055 19084 56147807
Asthenia 47.69 10.76 510 124666 342463 55824428
Mucosal erosion 47.58 10.76 32 125144 1279 56165612
Mucosal disorder 47.54 10.76 38 125138 1988 56164903
Mydriasis 47.46 10.76 87 125089 10984 56155907
Dissociation 47.28 10.76 42 125134 2543 56164348
Intellectual disability 46.87 10.76 27 125149 817 56166074
Rash vesicular 46.86 10.76 50 125126 3795 56163096
Injection site pain 46.76 10.76 121 125055 116997 56049894
Oral disorder 46.68 10.76 73 125103 8102 56158789
Malaise 46.07 10.76 560 124616 367300 55799591
Parkinsonism 46.06 10.76 79 125097 9467 56157424
Lip ulceration 45.81 10.76 36 125140 1837 56165054
Productive cough 45.51 10.76 35 125141 56197 56110694
Developmental hip dysplasia 45.20 10.76 31 125145 1280 56165611
Blood cholesterol increased 45.11 10.76 57 125119 72522 56094369
Disorientation 45.06 10.76 181 124995 36432 56130459
Logorrhoea 44.59 10.76 39 125137 2313 56164578
Hypotonia neonatal 44.59 10.76 29 125147 1095 56165796
Eyelid erosion 44.29 10.76 12 125164 38 56166853
Retrognathia 44.24 10.76 21 125155 422 56166469
Conjunctival abrasion 44.18 10.76 11 125165 22 56166869
Drug withdrawal convulsions 44.13 10.76 31 125145 1331 56165560
Sepsis 44.07 10.76 161 125015 139679 56027212
Lactic acidosis 44.06 10.76 12 125164 35334 56131557
Abdominal pain 44.02 10.76 366 124810 258439 55908452
Persecutory delusion 43.55 10.76 40 125136 2530 56164361
Cyanosis neonatal 43.24 10.76 18 125158 261 56166630
Live birth 43.11 10.76 118 125058 19487 56147404
Oedema peripheral 43.02 10.76 215 124961 171039 55995852
Tonic convulsion 42.53 10.76 29 125147 1186 56165705
Vision blurred 42.50 10.76 323 124853 82620 56084271
Simple partial seizures 42.39 10.76 22 125154 539 56166352
Lung disorder 42.23 10.76 33 125143 52564 56114327
Stomatitis 42.21 10.76 133 125043 120677 56046214
Coarctation of the aorta 41.95 10.76 22 125154 551 56166340
Photophobia 41.87 10.76 103 125073 15947 56150944
Microcephaly 41.86 10.76 25 125151 810 56166081
Lymphocyte morphology abnormal 41.81 10.76 20 125156 409 56166482
Agitation neonatal 41.70 10.76 21 125155 482 56166409
Treatment noncompliance 41.54 10.76 163 125013 32460 56134431
Constipation 41.32 10.76 271 124905 201672 55965219
Dysarthria 41.30 10.76 186 124990 39364 56127527
Dehydration 41.27 10.76 197 124979 158628 56008263
Apathy 41.27 10.76 68 125108 7886 56159005
Conjunctivitis 41.02 10.76 110 125066 17950 56148941
Antipsychotic drug level increased 41.01 10.76 43 125133 3199 56163692
Abdominal pain upper 40.82 10.76 231 124945 178082 55988809
Autism spectrum disorder 40.68 10.76 24 125152 760 56166131
Catatonia 40.49 10.76 47 125129 3917 56162974
Low set ears 40.44 10.76 17 125159 253 56166638
Paradoxical drug reaction 40.20 10.76 46 125130 3774 56163117
Spina bifida 40.01 10.76 24 125152 784 56166107
Central nervous system lesion 39.99 10.76 76 125100 9862 56157029
Pregnancy with implant contraceptive 39.80 10.76 36 125140 2232 56164659
Thrombosis 39.79 10.76 44 125132 59383 56107508
Hydrops foetalis 39.76 10.76 20 125156 458 56166433
Nightmare 39.75 10.76 104 125072 16722 56150169
Deep vein thrombosis 39.52 10.76 69 125107 76908 56089983
Bursitis 39.15 10.76 7 125169 27575 56139316
Intermenstrual bleeding 39.08 10.76 62 125114 6965 56159926
Drug dose titration not performed 38.83 10.76 20 125156 482 56166409
Erythema 38.81 10.76 523 124653 155416 56011475
Gamma-glutamyltransferase increased 38.73 10.76 154 125022 30851 56136040
Exposure via ingestion 38.69 10.76 39 125137 2769 56164122
Withdrawal syndrome 38.51 10.76 109 125067 18353 56148538
Crying 38.47 10.76 120 125056 21320 56145571
Respiratory depression 38.12 10.76 85 125091 12350 56154541
Anticonvulsant drug level below therapeutic 38.09 10.76 21 125155 583 56166308
Rapid eye movement sleep behaviour disorder 38.08 10.76 15 125161 187 56166704
Chest discomfort 38.04 10.76 104 125072 98753 56068138
Neoplasm progression 37.84 10.76 12 125164 32004 56134887
Nausea 37.76 10.76 1356 123820 762822 55404069
Renal failure 37.66 10.76 123 125053 110377 56056514
Encephalopathy 37.54 10.76 167 125009 35158 56131733
Product dispensing error 37.46 10.76 71 125105 9193 56157698
Flat affect 37.31 10.76 28 125148 1334 56165557
Rectal haemorrhage 37.29 10.76 23 125153 41444 56125447
Paranoia 37.02 10.76 77 125099 10667 56156224
Joint range of motion decreased 36.97 10.76 6 125170 25359 56141532
Blood pressure fluctuation 36.84 10.76 22 125154 40338 56126553
Disseminated intravascular coagulation 36.73 10.76 105 125071 17780 56149111
Metastases to liver 36.69 10.76 3 125173 21583 56145308
Osteoporosis 36.57 10.76 37 125139 52015 56114876
Renal impairment 36.52 10.76 78 125098 80635 56086256
Femur fracture 36.46 10.76 21 125155 39274 56127617
Hostility 36.00 10.76 31 125145 1800 56165091
Cellulitis 35.98 10.76 70 125106 74879 56092012
Epidermal necrosis 35.76 10.76 24 125152 956 56165935
Hypotonia 35.71 10.76 67 125109 8610 56158281
Traumatic coma 35.69 10.76 11 125165 61 56166830
Concussion 35.60 10.76 65 125111 8181 56158710
Benzodiazepine drug level increased 35.58 10.76 14 125162 174 56166717
Obsessive thoughts 35.34 10.76 19 125157 501 56166390
Sinus tachycardia 35.20 10.76 120 125056 22324 56144567
Pulmonary arterial hypertension 34.97 10.76 8 125168 26495 56140396
Abnormal palmar/plantar creases 34.91 10.76 10 125166 41 56166850
Pregnancy on contraceptive 34.66 10.76 25 125151 1120 56165771
Amnesia 34.43 10.76 198 124978 46124 56120767
Urinary tract infection 34.06 10.76 356 124820 240157 55926734
Ureteric perforation 33.99 10.76 8 125168 11 56166880
Migraine 33.85 10.76 318 124858 86479 56080412
Angiofibroma 33.84 10.76 12 125164 109 56166782
Libido increased 33.79 10.76 26 125150 1286 56165605
Osteonecrosis of jaw 33.65 10.76 16 125160 33342 56133549
Multiple congenital abnormalities 33.65 10.76 19 125157 553 56166338
Hallucination, visual 33.42 10.76 100 125076 17368 56149523
Accessory auricle 33.29 10.76 7 125169 3 56166888
Nasal congestion 33.26 10.76 46 125130 56324 56110567
Stereotypy 33.19 10.76 17 125159 405 56166486
Lymphangioleiomyomatosis 33.15 10.76 13 125163 160 56166731
Photosensitivity reaction 33.12 10.76 85 125091 13508 56153383
Pharyngeal erythema 33.10 10.76 28 125148 1587 56165304
Full blood count decreased 32.98 10.76 6 125170 23343 56143548
Mucosal inflammation 32.95 10.76 28 125148 42782 56124109
Eosinophil percentage increased 32.88 10.76 23 125153 981 56165910
Coma scale abnormal 32.88 10.76 47 125129 4816 56162075
Blood lactate dehydrogenase increased 32.83 10.76 111 125065 20564 56146327
Melaena 32.74 10.76 11 125165 28279 56138612
Skin erosion 32.60 10.76 33 125143 2355 56164536
Tubulointerstitial nephritis and uveitis syndrome 32.56 10.76 14 125162 221 56166670
Basal cell carcinoma 32.51 10.76 8 125168 25213 56141678
Acute respiratory distress syndrome 32.46 10.76 115 125061 21811 56145080
Rhabdomyolysis 32.35 10.76 177 124999 40481 56126410
Salivary hypersecretion 32.26 10.76 57 125119 6993 56159898
Purpura 31.95 10.76 71 125105 10291 56156600
Resting tremor 31.95 10.76 20 125156 706 56166185
Arnold-Chiari malformation 31.83 10.76 19 125157 615 56166276
Loss of personal independence in daily activities 31.76 10.76 85 125091 81284 56085607
Exomphalos 31.54 10.76 18 125158 535 56166356
Bipolar II disorder 31.53 10.76 15 125161 303 56166588
Drug resistance 31.49 10.76 109 125067 20433 56146458
Depressive symptom 31.28 10.76 39 125137 3502 56163389
Persistent genital arousal disorder 31.17 10.76 15 125161 311 56166580
Macular degeneration 31.13 10.76 3 125173 18905 56147986
Pulmonary oedema 30.92 10.76 41 125135 51102 56115789
Postictal psychosis 30.91 10.76 8 125168 20 56166871
Infantile apnoea 30.56 10.76 21 125155 870 56166021
Neonatal respiratory distress syndrome 30.41 10.76 34 125142 2720 56164171
Vomiting projectile 30.27 10.76 24 125152 1241 56165650
Genital erosion 30.15 10.76 12 125164 154 56166737
Weight gain poor 30.08 10.76 20 125156 784 56166107
Acute myocardial infarction 30.02 10.76 15 125161 30378 56136513
Congenital skin dimples 30.00 10.76 11 125165 111 56166780
Pleural effusion 29.93 10.76 94 125082 85386 56081505
Brain death 29.85 10.76 35 125141 2948 56163943
Neurotoxicity 29.82 10.76 90 125086 15705 56151186
Erythema of eyelid 29.78 10.76 29 125147 1975 56164916
Lymphadenitis 29.74 10.76 35 125141 2960 56163931
Drug screen false positive 29.73 10.76 20 125156 800 56166091
Haemoptysis 29.58 10.76 11 125165 26549 56140342
Oesophageal atresia 29.55 10.76 17 125159 513 56166378
Blood pressure diastolic decreased 29.48 10.76 4 125172 19319 56147572
Respiratory disorder neonatal 29.46 10.76 21 125155 923 56165968
Hemivertebra 29.40 10.76 11 125165 118 56166773
Placental disorder 29.39 10.76 25 125151 1428 56165463
Red blood cell sedimentation rate increased 29.37 10.76 23 125153 36600 56130291
Major depression 29.29 10.76 57 125119 7527 56159364
Hyperbilirubinaemia neonatal 29.14 10.76 15 125161 361 56166530
Influenza 29.14 10.76 111 125065 95150 56071741
Cataract 29.07 10.76 43 125133 51204 56115687
Gambling disorder 29.03 10.76 23 125153 1188 56165703
Bradycardia neonatal 28.93 10.76 20 125156 837 56166054
Blood creatinine increased 28.92 10.76 87 125089 80104 56086787
Premature labour 28.64 10.76 74 125102 11808 56155083
Psychotic symptom 28.60 10.76 24 125152 1345 56165546
Illusion 28.49 10.76 21 125155 973 56165918
Chloropsia 28.08 10.76 8 125168 32 56166859
Neutropenia 27.63 10.76 222 124954 157945 56008946
Transaminases increased 27.60 10.76 132 125044 28638 56138253
Metastases to bone 27.58 10.76 5 125171 19503 56147388
Retinogram abnormal 27.17 10.76 11 125165 148 56166743
Pulmonary hypertension 27.07 10.76 24 125152 35920 56130971
Night sweats 27.06 10.76 31 125145 41182 56125709
Abortion missed 26.98 10.76 25 125151 1599 56165292
Ischaemic stroke 26.88 10.76 3 125173 16839 56150052
Panic attack 26.71 10.76 103 125073 20344 56146547
Pyloric stenosis 26.68 10.76 14 125162 351 56166540
Bone pain 26.66 10.76 44 125132 50141 56116750
Product quality issue 26.49 10.76 140 125036 31596 56135295
Haematochezia 26.48 10.76 35 125141 43683 56123208
Vestibular migraine 26.38 10.76 12 125164 218 56166673
Inflammation 26.32 10.76 73 125103 68998 56097893
Vulvar erosion 26.21 10.76 11 125165 163 56166728
Seizure cluster 26.18 10.76 12 125164 222 56166669
Pregnancy with contraceptive device 26.09 10.76 39 125137 4160 56162731
Pulmonary fibrosis 26.08 10.76 17 125159 29741 56137150
Ascites 26.02 10.76 27 125149 37517 56129374
Angina pectoris 25.88 10.76 15 125161 27961 56138930
Neoplasm malignant 25.76 10.76 14 125162 27041 56139850
Plagiocephaly 25.71 10.76 8 125168 46 56166845
Hyperprolactinaemia 25.66 10.76 36 125140 3625 56163266
Osteomyelitis 25.62 10.76 11 125165 24335 56142556
Lung neoplasm malignant 25.61 10.76 4 125172 17392 56149499
Symblepharon 25.55 10.76 9 125167 80 56166811
Galactorrhoea 25.39 10.76 37 125139 3858 56163033
Product administration error 25.38 10.76 103 125073 20826 56146065
Hypoglycaemia neonatal 25.37 10.76 19 125157 902 56165989
Tonsillar hypertrophy 25.36 10.76 19 125157 903 56165988
Oedema 25.35 10.76 95 125081 81825 56085066
Pseudolymphoma 25.28 10.76 16 125160 576 56166315
Injection site bruising 25.26 10.76 29 125147 38492 56128399
Hypomagnesaemia 25.23 10.76 12 125164 25003 56141888
Sternal fracture 25.16 10.76 27 125149 2063 56164828
Decreased appetite 25.07 10.76 340 124836 218891 55948000
Injection site pruritus 24.96 10.76 34 125142 41897 56124994
Eye movement disorder 24.92 10.76 41 125135 4748 56162143
Haemorrhoids 24.92 10.76 7 125169 20199 56146692
Heart rate decreased 24.86 10.76 32 125144 40395 56126496
Derealisation 24.78 10.76 20 125156 1061 56165830
Abdominal distension 24.69 10.76 89 125087 77537 56089354
Attention deficit hyperactivity disorder 24.68 10.76 30 125146 2624 56164267
Psychomotor skills impaired 24.63 10.76 27 125149 2113 56164778
Distractibility 24.59 10.76 14 125162 414 56166477
Self-medication 24.59 10.76 29 125147 2458 56164433
Learning disorder 24.49 10.76 16 125160 609 56166282
Electrocardiogram ST segment depression 24.42 10.76 30 125146 2653 56164238
Wrong patient received product 24.31 10.76 27 125149 2144 56164747
Anomalous pulmonary venous connection 24.25 10.76 8 125168 57 56166834
Hepatocellular injury 24.25 10.76 120 125056 26394 56140497
Lymphocytic infiltration 24.23 10.76 18 125158 844 56166047
Abnormal dreams 24.20 10.76 61 125115 9588 56157303
Oral mucosal blistering 24.13 10.76 42 125134 5092 56161799
Cerebral infarction 23.95 10.76 10 125166 22495 56144396
Epstein-Barr virus infection reactivation 23.78 10.76 16 125160 640 56166251
Congenital anomaly in offspring 23.78 10.76 10 125166 149 56166742
Cerebral atrophy 23.77 10.76 40 125136 4720 56162171
Hereditary ataxia 23.65 10.76 7 125169 33 56166858
Drug withdrawal syndrome 23.63 10.76 117 125059 25740 56141151
Persistent depressive disorder 23.61 10.76 18 125158 878 56166013
Miosis 23.60 10.76 48 125128 6544 56160347
Localised infection 23.56 10.76 16 125160 27396 56139495
Nephrogenic diabetes insipidus 23.54 10.76 18 125158 882 56166009
Soft tissue injury 23.50 10.76 23 125153 1576 56165315
Intention tremor 23.48 10.76 13 125163 364 56166527
Hepatosplenomegaly 23.44 10.76 28 125148 2405 56164486
Drug hypersensitivity 23.42 10.76 451 124725 274754 55892137
Educational problem 23.41 10.76 13 125163 366 56166525
Congenital hand malformation 23.38 10.76 12 125164 287 56166604
Cystitis 23.36 10.76 46 125130 48992 56117899
Affect lability 23.33 10.76 62 125114 10063 56156828
Persistent left superior vena cava 23.31 10.76 7 125169 35 56166856
Sleep paralysis 23.31 10.76 15 125161 556 56166335
Skin ulcer 23.29 10.76 31 125145 38577 56128314
Aphasia 23.25 10.76 131 125045 30284 56136607
Cholestasis of pregnancy 23.23 10.76 20 125156 1161 56165730
Choroidal coloboma 23.21 10.76 5 125171 3 56166888
Chronic kidney disease 23.17 10.76 36 125140 42020 56124871
Polyhydramnios 23.16 10.76 26 125150 2089 56164802
Poor sucking reflex 23.13 10.76 11 125165 222 56166669
Contusion 23.01 10.76 179 124997 128251 56038640
Flight of ideas 22.91 10.76 13 125163 382 56166509
Joint stiffness 22.88 10.76 27 125149 35398 56131493
Staring 22.86 10.76 22 125154 1476 56165415
Colitis 22.83 10.76 36 125140 41775 56125116
Negative symptoms in schizophrenia 22.72 10.76 9 125167 114 56166777
Hyperammonaemia 22.68 10.76 40 125136 4900 56161991
Anaphylactic shock 22.59 10.76 10 125166 21730 56145161
Self-injurious ideation 22.57 10.76 27 125149 2323 56164568
Distributive shock 22.53 10.76 19 125157 1072 56165819
Agranulocytosis 22.49 10.76 105 125071 22554 56144337
Lymphocyte stimulation test positive 22.42 10.76 14 125162 492 56166399
Psoriasis 22.33 10.76 118 125058 92574 56074317
Creatinine renal clearance decreased 22.24 10.76 3 125173 14556 56152335
Myocarditis 22.22 10.76 56 125120 8802 56158089
Off label use 22.20 10.76 1011 124165 555169 55611722
Hepatic function abnormal 22.05 10.76 142 125034 34416 56132475
Dysphoria 21.97 10.76 39 125137 4803 56162088
Coprolalia 21.91 10.76 6 125170 20 56166871
Hospitalisation 21.91 10.76 89 125087 74911 56091980
Drug ineffective for unapproved indication 21.90 10.76 114 125062 25579 56141312
Acquired immunodeficiency syndrome 21.88 10.76 8 125168 80 56166811
Feeling drunk 21.84 10.76 34 125142 3758 56163133
Entropion 21.84 10.76 7 125169 45 56166846
Hypokalaemia 21.77 10.76 122 125054 94315 56072576
Blood creatine phosphokinase increased 21.77 10.76 121 125055 27831 56139060
Normal newborn 21.71 10.76 50 125126 7420 56159471
Irregular sleep phase 21.69 10.76 6 125170 21 56166870
Retinal pigment epitheliopathy 21.62 10.76 10 125166 189 56166702
Dysphemia 21.58 10.76 27 125149 2433 56164458
Congenital anomaly 21.56 10.76 22 125154 1585 56165306
Palmar-plantar erythrodysaesthesia syndrome 21.41 10.76 10 125166 21055 56145836
Change in seizure presentation 21.36 10.76 11 125165 265 56166626
Pulmonary embolism 21.26 10.76 145 125031 106979 56059912
Cataplexy 21.17 10.76 20 125156 1311 56165580
Gastric ulcer 21.01 10.76 12 125164 22551 56144340
Impatience 20.92 10.76 12 125164 360 56166531
Head titubation 20.91 10.76 16 125160 785 56166106
Upper gastrointestinal haemorrhage 20.86 10.76 6 125170 17048 56149843
Cardiac malposition 20.86 10.76 7 125169 53 56166838
Lennox-Gastaut syndrome 20.78 10.76 11 125165 281 56166610
Hypocalcaemia 20.71 10.76 20 125156 28740 56138151
Conjunctival disorder 20.71 10.76 10 125166 209 56166682
Self esteem decreased 20.68 10.76 14 125162 566 56166325
Dysmetria 20.67 10.76 13 125163 463 56166428
Somnambulism 20.56 10.76 39 125137 5053 56161838
Disinhibition 20.56 10.76 16 125160 805 56166086
Angiomyolipoma 20.54 10.76 10 125166 213 56166678
Drug level changed 20.54 10.76 10 125166 213 56166678
Interstitial lung disease 20.50 10.76 62 125114 57001 56109890
Oral hairy leukoplakia 20.44 10.76 4 125172 0 56166891
Granulocytopenia 20.44 10.76 40 125136 5304 56161587
Injury corneal 20.41 10.76 7 125169 57 56166834
Thyroiditis 20.41 10.76 24 125152 2028 56164863
Illogical thinking 20.31 10.76 7 125169 58 56166833
Hypersomnia 20.28 10.76 81 125095 16260 56150631
Sinus congestion 20.24 10.76 5 125171 15719 56151172
Cardiac disorder 20.21 10.76 45 125131 45842 56121049
Foetal death 20.21 10.76 53 125123 8534 56158357
Automatism 20.20 10.76 7 125169 59 56166832
Alanine aminotransferase increased 20.04 10.76 306 124870 93356 56073535
Brain oedema 19.98 10.76 70 125106 13201 56153690
Drug level fluctuating 19.95 10.76 12 125164 394 56166497
Tachyphrenia 19.87 10.76 19 125157 1265 56165626
Device related infection 19.86 10.76 12 125164 21868 56145023
Gestational hypertension 19.80 10.76 25 125151 2274 56164617
Breast cancer metastatic 19.76 10.76 5 125171 15464 56151427
Antidepressant drug level above therapeutic 19.76 10.76 12 125164 401 56166490
Drooling 19.67 10.76 31 125145 3463 56163428
Mouth ulceration 19.66 10.76 123 125053 29517 56137374
Hypervolaemia 19.52 10.76 18 125158 26440 56140451
Heart rate increased 19.51 10.76 107 125069 83166 56083725
Dermatitis exfoliative 19.46 10.76 39 125137 5260 56161631
Post-traumatic neck syndrome 19.45 10.76 23 125153 1955 56164936
Psychiatric symptom 19.43 10.76 37 125139 4807 56162084
Tension 19.39 10.76 28 125148 2896 56163995
Echolalia 19.27 10.76 9 125167 174 56166717
Macule 19.23 10.76 21 125155 1636 56165255
SJS-TEN overlap 19.23 10.76 10 125166 246 56166645
Psychiatric decompensation 19.20 10.76 19 125157 1319 56165572
Dermatitis bullous 19.12 10.76 48 125128 7525 56159366
Skin exfoliation 19.06 10.76 144 125032 36756 56130135
External auditory canal atresia 19.06 10.76 7 125169 71 56166820
Hiatus hernia 18.96 10.76 10 125166 19642 56147249
Laryngeal ulceration 18.91 10.76 5 125171 14 56166877
Oral mucosal eruption 18.86 10.76 14 125162 656 56166235
Drop attacks 18.84 10.76 14 125162 657 56166234
Limbic encephalitis 18.83 10.76 10 125166 257 56166634
Skin lesion 18.82 10.76 117 125059 28018 56138873
Developmental delay 18.80 10.76 19 125157 1353 56165538
Scab 18.77 10.76 45 125131 6853 56160038
Sleep-related eating disorder 18.69 10.76 15 125161 789 56166102
Anorgasmia 18.63 10.76 13 125163 552 56166339
Coma scale 18.53 10.76 6 125170 40 56166851
Abortion 18.48 10.76 24 125152 2245 56164646
Hippocampal sclerosis 18.47 10.76 7 125169 78 56166813
Lipids 18.41 10.76 5 125171 16 56166875
Iris coloboma 18.41 10.76 6 125170 41 56166850
Oscillopsia 18.34 10.76 8 125168 131 56166760
Postictal state 18.32 10.76 16 125160 947 56165944
Breast cancer 18.31 10.76 52 125124 48781 56118110
Mononucleosis syndrome 18.28 10.76 8 125168 132 56166759
Bile acid malabsorption 18.22 10.76 9 125167 198 56166693
Congenital anaemia 18.21 10.76 4 125172 3 56166888
Lip scab 18.21 10.76 4 125172 3 56166888
Histiocytosis 18.18 10.76 5 125171 17 56166874
Foetal heart rate deceleration abnormality 18.17 10.76 12 125164 465 56166426
Lipids abnormal 18.12 10.76 10 125166 278 56166613
Postmortem blood drug level 18.12 10.76 8 125168 135 56166756
Overweight 18.10 10.76 29 125147 3285 56163606
Cleft palate 18.01 10.76 16 125160 969 56165922
Brachycephaly 17.96 10.76 5 125171 18 56166873
Muscle spasms 17.96 10.76 207 124969 137164 56029727
Cerebral ventricle dilatation 17.90 10.76 16 125160 977 56165914
Ejection fraction decreased 17.85 10.76 11 125165 19830 56147061
Foot deformity 17.83 10.76 16 125160 23809 56143082
Borderline personality disorder 17.81 10.76 14 125162 715 56166176
Grip strength decreased 17.66 10.76 7 125169 16249 56150642
Increased appetite 17.66 10.76 51 125125 8684 56158207
Meningomyelocele 17.64 10.76 13 125163 602 56166289
Pre-eclampsia 17.60 10.76 50 125126 8436 56158455
Periodic limb movement disorder 17.58 10.76 9 125167 214 56166677
Hepatic cirrhosis 17.50 10.76 13 125163 21250 56145641
Tricuspid valve incompetence 17.49 10.76 4 125172 13249 56153642
Negativism 17.48 10.76 11 125165 392 56166499
Haematemesis 17.44 10.76 23 125153 28735 56138156
Wound infection 17.42 10.76 6 125170 15187 56151704
Lymph node pain 17.41 10.76 18 125158 1317 56165574
Cerebellar ataxia 17.41 10.76 15 125161 872 56166019
Metastases to central nervous system 17.40 10.76 3 125173 12133 56154758
Delivery 17.38 10.76 15 125161 874 56166017
Urinary incontinence 17.33 10.76 119 125057 29466 56137425
Learning disability 17.32 10.76 9 125167 221 56166670
Septic shock 17.26 10.76 73 125103 60762 56106129
Alopecia universalis 17.23 10.76 7 125169 95 56166796
Ill-defined disorder 17.22 10.76 86 125090 68457 56098434
Epidermolysis 17.21 10.76 9 125167 224 56166667
Haematocrit decreased 17.15 10.76 35 125141 36794 56130097
Parachute mitral valve 17.10 10.76 7 125169 97 56166794
Urinary retention 17.09 10.76 114 125062 27960 56138931
Screaming 17.06 10.76 27 125149 3027 56163864
Dyspepsia 17.06 10.76 112 125064 83359 56083532
Viral rash 17.05 10.76 10 125166 313 56166578
Spinal stenosis 17.02 10.76 5 125171 14009 56152882
Juvenile myoclonic epilepsy 16.99 10.76 5 125171 23 56166868
Neuropsychiatric symptoms 16.98 10.76 13 125163 638 56166253
Haematuria 16.97 10.76 21 125155 26966 56139925
Cytomegalovirus infection 16.94 10.76 11 125165 19285 56147606
Weight decreased 16.84 10.76 407 124769 240307 55926584
Suicide threat 16.82 10.76 5 125171 24 56166867
Hypercalcaemia 16.80 10.76 19 125157 25392 56141499
Middle insomnia 16.69 10.76 58 125118 10892 56155999
Strabismus 16.67 10.76 21 125155 1905 56164986
Adrenal insufficiency 16.66 10.76 7 125169 15690 56151201
Anal erosion 16.65 10.76 5 125171 25 56166866
Sciatica 16.61 10.76 20 125156 25990 56140901
Bone density decreased 16.54 10.76 4 125172 12756 56154135
Platelet count decreased 16.48 10.76 154 125022 106229 56060662
White blood cell count increased 16.46 10.76 162 125014 44597 56122294
Poor feeding infant 16.42 10.76 9 125167 247 56166644
Myelodysplastic syndrome 16.35 10.76 8 125168 16398 56150493
Tonic clonic movements 16.34 10.76 17 125159 1253 56165638
Apnoea 16.33 10.76 44 125132 7198 56159693
Suppressed lactation 16.33 10.76 11 125165 441 56166450
Injection site reaction 16.31 10.76 62 125114 53185 56113706
Pulmonary mass 16.23 10.76 13 125163 20457 56146434
Cerebellar atrophy 16.18 10.76 13 125163 685 56166206
Herpangina 16.18 10.76 5 125171 28 56166863
Gait deviation 16.15 10.76 6 125170 63 56166828
Transfusion 16.10 10.76 5 125171 13515 56153376
Heavy menstrual bleeding 16.01 10.76 75 125101 16134 56150757
Peritonitis 15.99 10.76 8 125168 16194 56150697
Corneal erosion 15.97 10.76 9 125167 261 56166630
Hypercapnic coma 15.95 10.76 8 125168 182 56166709
Upper respiratory tract infection 15.94 10.76 93 125083 71195 56095696
Hepatotoxicity 15.92 10.76 28 125148 31125 56135766
Cleft lip 15.92 10.76 7 125169 117 56166774
Drug tolerance decreased 15.90 10.76 5 125171 13406 56153485
Osteochondrosis 15.83 10.76 16 125160 1140 56165751
Nodule 15.83 10.76 11 125165 18608 56148283
Congenital aortic valve stenosis 15.82 10.76 6 125170 67 56166824
Product dose omission issue 15.78 10.76 341 124835 204412 55962479
Congenital ureteric anomaly 15.74 10.76 6 125170 68 56166823
Bradyphrenia 15.72 10.76 41 125135 6579 56160312
Vulval disorder 15.67 10.76 13 125163 717 56166174
Confusional state 15.63 10.76 588 124588 207567 55959324
Retinal coloboma 15.49 10.76 5 125171 33 56166858
Congenital oesophageal anomaly 15.45 10.76 4 125172 10 56166881
Tongue biting 15.44 10.76 17 125159 1337 56165554
Hepatitis 15.42 10.76 133 125043 35308 56131583
Homicidal ideation 15.39 10.76 19 125157 1689 56165202
Tearfulness 15.39 10.76 29 125147 3739 56163152
Type 2 diabetes mellitus 15.39 10.76 53 125123 46809 56120082
Laryngeal tremor 15.33 10.76 3 125173 0 56166891
Pharyngeal exudate 15.33 10.76 3 125173 0 56166891
Colitis ulcerative 15.31 10.76 19 125157 24372 56142519
Bezoar 15.30 10.76 17 125159 1351 56165540
Attention-seeking behaviour 15.29 10.76 6 125170 74 56166817
Throat irritation 15.27 10.76 31 125145 32652 56134239
Myelosuppression 15.26 10.76 10 125166 17445 56149446
Joint effusion 15.25 10.76 7 125169 14891 56152000
Multiple organ dysfunction syndrome 15.24 10.76 182 124994 52588 56114303
Rhinorrhoea 15.24 10.76 70 125106 56967 56109924
Economic problem 15.23 10.76 20 125156 1891 56165000
Tuberculosis 15.22 10.76 3 125173 11026 56155865
Dysmetropsia 15.22 10.76 6 125170 75 56166816
Injection site swelling 15.19 10.76 48 125128 43530 56123361
Selective IgA immunodeficiency 15.18 10.76 4 125172 11 56166880
Speech disorder developmental 15.14 10.76 12 125164 620 56166271
Morose 15.11 10.76 5 125171 36 56166855
Cardiac aneurysm 15.10 10.76 14 125162 896 56165995
Gastric disorder 15.10 10.76 32 125144 33178 56133713
Adverse drug reaction 15.09 10.76 84 125092 65048 56101843
Premature rupture of membranes 15.09 10.76 33 125143 4732 56162159
Mitral valve incompetence 15.07 10.76 11 125165 18142 56148749
Haemangioma 15.01 10.76 23 125153 2507 56164384
Body temperature decreased 15.00 10.76 11 125165 18097 56148794
Neurosurgery 14.88 10.76 5 125171 38 56166853
Bradykinesia 14.67 10.76 33 125143 4821 56162070
Toothache 14.63 10.76 11 125165 17869 56149022
Conjunctival oedema 14.60 10.76 12 125164 653 56166238
Drug screen positive 14.57 10.76 27 125149 3437 56163454
Acute myopia 14.54 10.76 6 125170 85 56166806
Retinal pigmentation 14.54 10.76 6 125170 85 56166806
Delusional perception 14.51 10.76 8 125168 222 56166669
Immunodeficiency 14.47 10.76 9 125167 16148 56150743
Hyperventilation 14.47 10.76 36 125140 5612 56161279
Placental infarction 14.45 10.76 9 125167 315 56166576
Conjunctival ulcer 14.44 10.76 5 125171 42 56166849
Menstrual disorder 14.38 10.76 32 125144 4643 56162248
Oral mucosal erythema 14.32 10.76 17 125159 1451 56165440
Therapy non-responder 14.28 10.76 79 125097 61276 56105615
Eyelid oedema 14.26 10.76 51 125125 9717 56157174
Injection site haemorrhage 14.25 10.76 17 125159 22184 56144707
COVID-19 14.20 10.76 103 125073 74955 56091936
Blood prolactin increased 14.18 10.76 26 125150 3283 56163608
Musculoskeletal disorder 14.16 10.76 13 125163 19134 56147757
Abulia 14.06 10.76 10 125166 438 56166453
Therapeutic product effective for unapproved indication 13.99 10.76 6 125170 94 56166797
Antipsychotic drug level above therapeutic 13.97 10.76 14 125162 987 56165904
Maternal exposure before pregnancy 13.95 10.76 40 125136 6783 56160108
Foetal malnutrition 13.94 10.76 6 125170 95 56166796
Eclampsia 13.93 10.76 9 125167 336 56166555
Breast cancer female 13.93 10.76 5 125171 12333 56154558
Hallucination, olfactory 13.92 10.76 8 125168 241 56166650
Skin cancer 13.91 10.76 3 125173 10352 56156539
Aspergillus test positive 13.90 10.76 9 125167 337 56166554
Hypoxia 13.90 10.76 67 125109 53830 56113061
Drug ineffective 13.86 10.76 1812 123364 917177 55249714
Potentiating drug interaction 13.84 10.76 29 125147 4037 56162854
Brain stem syndrome 13.76 10.76 9 125167 343 56166548
Musculoskeletal chest pain 13.75 10.76 14 125162 19627 56147264
Bacterial infection 13.75 10.76 11 125165 17319 56149572
Gastritis 13.73 10.76 36 125140 34666 56132225
Pneumocystis jirovecii pneumonia 13.72 10.76 9 125167 15692 56151199
Gout 13.71 10.76 5 125171 12216 56154675
Spinal compression fracture 13.71 10.76 6 125170 13128 56153763
Delusion of reference 13.71 10.76 6 125170 99 56166792
Spinal osteoarthritis 13.66 10.76 8 125168 14828 56152063
Spinal fracture 13.57 10.76 10 125166 16414 56150477
Lactation disorder 13.56 10.76 9 125167 352 56166539
Blood calcium decreased 13.42 10.76 20 125156 23749 56143142
Roseolovirus test positive 13.42 10.76 5 125171 53 56166838
Clostridium difficile infection 13.40 10.76 25 125151 27173 56139718
Cellulitis orbital 13.39 10.76 10 125166 473 56166418
Polydipsia 13.34 10.76 25 125151 3210 56163681
Exposure via transplant 13.32 10.76 4 125172 20 56166871
Hallucinations, mixed 13.29 10.76 30 125146 4394 56162497
Manic symptom 13.26 10.76 3 125173 3 56166888
Congenital emphysema 13.26 10.76 3 125173 3 56166888
Acquired epidermolysis bullosa 13.25 10.76 5 125171 55 56166836
Eosinophilic pneumonia 13.21 10.76 19 125157 1958 56164933
Mucosal ulceration 13.19 10.76 13 125163 898 56165993
Combined immunodeficiency 13.19 10.76 6 125170 109 56166782
Gastroschisis 13.16 10.76 8 125168 268 56166623
Decreased interest 13.14 10.76 24 125152 3022 56163869
White blood cell count decreased 13.12 10.76 199 124977 125791 56041100
Dry skin 13.08 10.76 57 125119 47052 56119839
Pulmonary congestion 13.07 10.76 10 125166 16105 56150786
Food interaction 13.05 10.76 12 125164 760 56166131
Head injury 13.05 10.76 98 125078 24968 56141923
Deja vu 13.02 10.76 5 125171 58 56166833
Lip disorder 12.99 10.76 15 125161 1243 56165648
Social avoidant behaviour 12.97 10.76 23 125153 2829 56164062
Emotional disorder 12.97 10.76 58 125118 12237 56154654
Cardiovascular symptom 12.94 10.76 5 125171 59 56166832
Holoprosencephaly 12.86 10.76 4 125172 23 56166868
Lymphoid tissue hyperplasia 12.84 10.76 7 125169 190 56166701
Accidental death 12.82 10.76 18 125158 1814 56165077
Metastases to lung 12.81 10.76 5 125171 11713 56155178
Flank pain 12.80 10.76 8 125168 14317 56152574
Directional Doppler flow tests abnormal 12.80 10.76 3 125173 4 56166887
Epidermolysis bullosa 12.76 10.76 6 125170 118 56166773
Pigmentation disorder 12.73 10.76 28 125148 4031 56162860
Retroperitoneal fibrosis 12.57 10.76 8 125168 291 56166600
Hypothermia 12.53 10.76 58 125118 12412 56154479
Lymphocytosis 12.53 10.76 20 125156 2258 56164633
Cogwheel rigidity 12.48 10.76 18 125158 1859 56165032
Fungal infection 12.47 10.76 35 125141 32958 56133933
Transient ischaemic attack 12.41 10.76 36 125140 33541 56133350
Unemployment 12.40 10.76 3 125173 5 56166886
Cardiomegaly 12.39 10.76 11 125165 16456 56150435
Anembryonic gestation 12.38 10.76 10 125166 531 56166360
Oesophagitis 12.36 10.76 8 125168 14049 56152842
Clumsiness 12.34 10.76 18 125158 1879 56165012
Phonophobia 12.30 10.76 8 125168 302 56166589
Bronchiectasis 12.30 10.76 5 125171 11429 56155462
Hip fracture 12.25 10.76 26 125150 26947 56139944
Personality disorder 12.25 10.76 32 125144 5141 56161750
Lethargy 12.15 10.76 171 125005 51270 56115621
Laryngitis 12.15 10.76 8 125168 13922 56152969
Skin disorder 12.12 10.76 100 125076 26209 56140682
Odynophagia 12.08 10.76 38 125138 6780 56160111
Heart rate irregular 12.07 10.76 17 125159 20662 56146229
Foetal growth restriction 12.06 10.76 39 125137 7060 56159831
Atrophy of globe 12.05 10.76 3 125173 6 56166885
Wound healing normal 12.05 10.76 3 125173 6 56166885
Delusional disorder, erotomanic type 11.95 10.76 4 125172 30 56166861
Homeless 11.92 10.76 5 125171 74 56166817
Medication overuse headache 11.92 10.76 11 125165 700 56166191
Flashback 11.90 10.76 6 125170 138 56166753
Status migrainosus 11.86 10.76 6 125170 139 56166752
Tongue eruption 11.86 10.76 5 125171 75 56166816
Mucosa vesicle 11.84 10.76 4 125172 31 56166860
Pityriasis rosea 11.74 10.76 5 125171 77 56166814
Paralogism 11.73 10.76 4 125172 32 56166859
Bankruptcy 11.73 10.76 4 125172 32 56166859
Initial insomnia 11.69 10.76 33 125143 5546 56161345
Posture abnormal 11.69 10.76 19 125157 2179 56164712
Drowning 11.66 10.76 9 125167 447 56166444
Hyperphagia 11.64 10.76 16 125160 1580 56165311
Diverticulum 11.64 10.76 5 125171 11061 56155830
Interleukin-2 receptor increased 11.62 10.76 5 125171 79 56166812
Hepatic encephalopathy 11.58 10.76 4 125172 10106 56156785
Gastroenteritis 11.54 10.76 23 125153 24389 56142502
Blunted affect 11.50 10.76 7 125169 235 56166656
Dysphonia 11.49 10.76 51 125125 41896 56124995
Tendonitis 11.46 10.76 14 125162 18083 56148808
Emotional poverty 11.42 10.76 8 125168 342 56166549
Blood iron decreased 11.36 10.76 7 125169 12620 56154271
Conversion disorder 11.32 10.76 16 125160 1622 56165269
Induced labour 11.29 10.76 12 125164 907 56165984
Anorexia nervosa 11.26 10.76 7 125169 244 56166647
Ankylosing spondylitis 11.25 10.76 4 125172 9926 56156965
Accidental overdose 11.22 10.76 81 125095 20380 56146511
Congenital gastric anomaly 11.19 10.76 3 125173 9 56166882
Blood pressure decreased 11.19 10.76 81 125095 58969 56107922
Spinal cord infarction 11.19 10.76 7 125169 247 56166644
Depression suicidal 11.17 10.76 16 125160 1642 56165249
Nervous system disorder 11.15 10.76 70 125106 16819 56150072
Monocyte percentage increased 11.13 10.76 13 125163 1090 56165801
Poor weight gain neonatal 11.08 10.76 5 125171 89 56166802
Vulval oedema 11.03 10.76 4 125172 39 56166852
Malignant melanoma 11.03 10.76 5 125171 10714 56156177
Tonsillar haemorrhage 11.01 10.76 7 125169 254 56166637
Conjunctival erosion 10.98 10.76 5 125171 91 56166800
Acute psychosis 10.98 10.76 19 125157 2293 56164598
Blood pressure systolic abnormal 10.97 10.76 4 125172 9773 56157118
Alexia 10.96 10.76 3 125173 10 56166881
Head circumference abnormal 10.96 10.76 3 125173 10 56166881
Lip haemorrhage 10.95 10.76 9 125167 490 56166401
Nikolsky's sign 10.93 10.76 5 125171 92 56166799
Ocular hyperaemia 10.92 10.76 85 125091 21894 56144997
Injection site rash 10.87 10.76 13 125163 16945 56149946
Visual field defect 10.85 10.76 34 125142 6055 56160836
Teratogenicity 10.82 10.76 7 125169 262 56166629
Full blood count abnormal 10.81 10.76 27 125149 26435 56140456

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1702.34 12.31 1505 64174 98263 31533402
Foetal exposure during pregnancy 1051.33 12.31 785 64894 40091 31591574
Epilepsy 723.69 12.31 483 65196 20558 31611107
Stevens-Johnson syndrome 661.34 12.31 425 65254 16947 31614718
Completed suicide 560.15 12.31 811 64868 90703 31540962
Generalised tonic-clonic seizure 492.23 12.31 374 65305 19557 31612108
Drug reaction with eosinophilia and systemic symptoms 474.34 12.31 435 65244 29583 31602082
Status epilepticus 418.68 12.31 279 65400 11827 31619838
Toxicity to various agents 408.74 12.31 1051 64628 180436 31451229
Product substitution issue 399.51 12.31 247 65432 9185 31622480
Ataxia 357.01 12.31 259 65420 12604 31619061
Aggression 345.67 12.31 406 65273 36885 31594780
Exposure during pregnancy 311.44 12.31 204 65475 8394 31623271
Atrial septal defect 259.81 12.31 168 65511 6759 31624906
Suicide attempt 237.41 12.31 337 65342 36911 31594754
Drug level increased 223.18 12.31 241 65438 19945 31611720
Toxic epidermal necrolysis 222.74 12.31 237 65442 19287 31612378
Diarrhoea 217.27 12.31 247 65432 352162 31279503
Agitation 213.59 12.31 394 65285 53775 31577890
Febrile neutropenia 210.64 12.31 10 65669 121839 31509826
Somnolence 204.89 12.31 558 65121 98887 31532778
Dyspnoea 201.80 12.31 250 65429 343229 31288436
Rash 198.33 12.31 884 64795 200602 31431063
Intentional overdose 177.08 12.31 312 65367 41077 31590588
Partial seizures 173.91 12.31 110 65569 4256 31627409
Pneumonia 171.93 12.31 269 65410 335043 31296622
Exposure via breast milk 169.57 12.31 81 65598 1779 31629886
Mania 168.70 12.31 145 65534 9032 31622633
Death 165.90 12.31 310 65369 360259 31271406
Anaemia 165.35 12.31 121 65558 213401 31418264
Abnormal behaviour 164.35 12.31 224 65455 23604 31608061
Drug interaction 163.33 12.31 857 64822 207686 31423979
Irritability 159.12 12.31 216 65463 22673 31608992
Hypospadias 156.28 12.31 91 65588 3025 31628640
Acute kidney injury 141.70 12.31 226 65453 279488 31352177
Sudden unexplained death in epilepsy 140.68 12.31 48 65631 416 31631249
Autism spectrum disorder 131.44 12.31 72 65607 2123 31629542
Petit mal epilepsy 130.57 12.31 79 65600 2821 31628844
Cardiac failure congestive 129.53 12.31 9 65670 79378 31552287
Patent ductus arteriosus 126.06 12.31 80 65599 3113 31628552
Myocardial infarction 124.53 12.31 40 65639 113414 31518251
Infantile apnoea 121.09 12.31 52 65627 882 31630783
Multiple-drug resistance 119.26 12.31 88 65591 4392 31627273
Maternal exposure during breast feeding 118.93 12.31 60 65619 1489 31630176
Maternal exposure during pregnancy 118.45 12.31 89 65590 4567 31627098
Respiratory disorder neonatal 117.99 12.31 59 65620 1436 31630229
Coma 117.62 12.31 262 65417 40888 31590777
Rash maculo-papular 116.64 12.31 199 65480 25520 31606145
Ventricular septal defect 115.77 12.31 80 65599 3597 31628068
Overdose 113.91 12.31 410 65269 84254 31547411
Brugada syndrome 113.35 12.31 46 65633 672 31630993
Bipolar disorder 112.52 12.31 79 65600 3645 31628020
Drug withdrawal syndrome neonatal 112.36 12.31 77 65602 3415 31628250
Dysmorphism 111.49 12.31 73 65606 2999 31628666
Maternal drugs affecting foetus 106.91 12.31 78 65601 3825 31627840
Myoclonus 106.41 12.31 138 65541 13852 31617813
Neonatal respiratory distress syndrome 104.96 12.31 77 65602 3808 31627857
Arthralgia 104.43 12.31 96 65583 151328 31480337
Atrial fibrillation 103.92 12.31 53 65626 113730 31517935
Congenital anomaly 103.34 12.31 52 65627 1283 31630382
Cognitive disorder 102.84 12.31 185 65494 24738 31606927
Malignant neoplasm progression 101.80 12.31 20 65659 78978 31552687
Hypomania 100.92 12.31 61 65618 2174 31629491
Attention deficit hyperactivity disorder 99.48 12.31 62 65617 2336 31629329
Drug eruption 99.17 12.31 153 65526 18034 31613631
Speech disorder developmental 96.82 12.31 58 65621 2033 31629632
Conjunctival hyperaemia 96.26 12.31 59 65620 2157 31629508
Focal dyscognitive seizures 95.46 12.31 49 65630 1262 31630403
Oral mucosa erosion 94.88 12.31 43 65636 834 31630831
Selective eating disorder 93.65 12.31 53 65626 1667 31629998
Lip erosion 93.64 12.31 37 65642 502 31631163
Pain 92.42 12.31 153 65526 186606 31445059
Oculogyric crisis 90.66 12.31 49 65630 1406 31630259
Psychomotor hyperactivity 90.30 12.31 101 65578 8686 31622979
Suicidal ideation 90.00 12.31 219 65460 36187 31595478
Electrocardiogram QRS complex prolonged 88.44 12.31 72 65607 4157 31627508
Cardiac failure 87.96 12.31 34 65645 85919 31545746
Intentional self-injury 85.54 12.31 121 65558 13194 31618471
Developmental delay 85.14 12.31 58 65621 2547 31629118
Hypotonia neonatal 84.12 12.31 45 65634 1264 31630401
Haemophagocytic lymphohistiocytosis 83.87 12.31 112 65567 11566 31620099
Obsessive-compulsive disorder 82.69 12.31 74 65605 4863 31626802
Bradycardia neonatal 82.45 12.31 40 65639 910 31630755
Interstitial lung disease 82.43 12.31 14 65665 61389 31570276
Accidental exposure to product by child 81.02 12.31 46 65633 1456 31630209
Neonatal infection 80.85 12.31 31 65648 386 31631279
Disease progression 79.84 12.31 44 65635 90420 31541245
Sepsis 79.36 12.31 120 65559 151809 31479856
Crying 78.51 12.31 76 65603 5521 31626144
Agitation neonatal 77.48 12.31 40 65639 1043 31630622
Cough 73.82 12.31 103 65576 134711 31496954
Electroencephalogram abnormal 73.58 12.31 51 65628 2304 31629361
Neurodevelopmental disorder 73.49 12.31 29 65650 392 31631273
Plasma cell myeloma 73.48 12.31 14 65665 56517 31575148
Disturbance in attention 73.40 12.31 151 65528 22299 31609366
Aura 72.78 12.31 27 65652 305 31631360
Postictal psychosis 71.93 12.31 23 65656 159 31631506
Pain in extremity 71.73 12.31 81 65598 116122 31515543
Anger 71.12 12.31 101 65578 11052 31620613
Coronary artery disease 70.26 12.31 7 65672 46080 31585585
Premature baby 68.10 12.31 129 65550 17937 31613728
Tremor 67.97 12.31 326 65353 76094 31555571
Abdominal pain 66.34 12.31 126 65553 145826 31485839
Gaze palsy 66.31 12.31 40 65639 1420 31630245
Pulmonary embolism 66.04 12.31 44 65635 81602 31550063
Neonatal tachypnoea 64.84 12.31 21 65658 152 31631513
Anticonvulsant drug level above therapeutic 64.41 12.31 30 65649 621 31631044
Oedema peripheral 64.12 12.31 80 65599 109759 31521906
Joint swelling 63.83 12.31 16 65663 53415 31578250
Haemoglobin decreased 63.77 12.31 84 65595 112591 31519074
Restlessness 63.66 12.31 146 65533 23215 31608450
Gastrointestinal haemorrhage 63.45 12.31 47 65632 82502 31549163
Balance disorder 63.40 12.31 196 65483 37226 31594439
Sedation 62.51 12.31 128 65551 18837 31612828
Nystagmus 61.39 12.31 60 65619 4410 31627255
Excessive eye blinking 61.31 12.31 27 65652 488 31631177
Depression 61.29 12.31 359 65320 90456 31541209
Back pain 60.47 12.31 83 65596 109330 31522335
Talipes 60.09 12.31 41 65638 1805 31629860
Myoclonic epilepsy 59.83 12.31 34 65645 1078 31630587
Conjunctivitis 59.33 12.31 81 65598 8542 31623123
Acute myocardial infarction 59.22 12.31 16 65663 50807 31580858
Tardive dyskinesia 59.02 12.31 65 65614 5494 31626171
Infection 58.76 12.31 50 65629 81881 31549784
Neuroleptic malignant syndrome 58.15 12.31 116 65563 16753 31614912
Bipolar I disorder 58.05 12.31 30 65649 784 31630881
Psychotic disorder 57.11 12.31 136 65543 22157 31609508
Dystonia 57.11 12.31 87 65592 10138 31621527
Pleural effusion 55.86 12.31 44 65635 74876 31556789
Neuropathy peripheral 55.69 12.31 45 65634 75604 31556061
Weight decreased 55.14 12.31 160 65519 159792 31471873
Hypertension 54.42 12.31 115 65564 127985 31503680
Mydriasis 53.56 12.31 67 65612 6485 31625180
Partial seizures with secondary generalisation 53.48 12.31 21 65658 280 31631385
Psychomotor retardation 52.99 12.31 48 65631 3204 31628461
Infusion related reaction 52.58 12.31 17 65662 48038 31583627
Apathy 52.53 12.31 66 65613 6416 31625249
Antipsychotic drug level increased 52.39 12.31 49 65630 3409 31628256
Platelet count decreased 52.24 12.31 93 65586 110342 31521323
Asthenia 52.17 12.31 264 65415 224491 31407174
Behaviour disorder 51.73 12.31 54 65625 4293 31627372
Neutropenia 51.65 12.31 136 65543 140228 31491437
General physical health deterioration 51.46 12.31 98 65581 113337 31518328
Hypotension 51.18 12.31 234 65445 204384 31427281
Tubulointerstitial nephritis and uveitis syndrome 51 12.31 15 65664 75 31631590
Hypoplastic left heart syndrome 50.95 12.31 19 65660 218 31631447
Erythema multiforme 49.86 12.31 72 65607 7999 31623666
Psychogenic seizure 49.84 12.31 21 65658 339 31631326
Blister 49.66 12.31 124 65555 20812 31610853
Peripheral swelling 49.16 12.31 41 65638 67824 31563841
Neonatal behavioural syndrome 48.91 12.31 16 65663 120 31631545
Overweight 48.78 12.31 34 65645 1550 31630115
Accidental overdose 48.15 12.31 113 65566 18237 31613428
Learning disorder 48.14 12.31 29 65650 1027 31630638
Blood prolactin increased 48.01 12.31 34 65645 1590 31630075
Anomaly of external ear congenital 47.77 12.31 15 65664 97 31631568
Prostate cancer 47.42 12.31 10 65669 37591 31594074
Cerebrovascular accident 47.31 12.31 57 65622 79427 31552238
Thinking abnormal 47.17 12.31 58 65621 5515 31626150
Mood altered 46.59 12.31 71 65608 8275 31623390
Nausea 45.81 12.31 413 65266 307534 31324131
Ascites 45.77 12.31 14 65665 40999 31590666
Dyskinesia 45.62 12.31 120 65559 20790 31610875
Poisoning 45.25 12.31 79 65600 10312 31621353
Hyperkalaemia 45.25 12.31 40 65639 64311 31567354
Renal impairment 45.23 12.31 68 65611 86281 31545384
Therapeutic response unexpected 45.15 12.31 73 65606 8951 31622714
Mucosal disorder 45.08 12.31 32 65647 1502 31630163
Anticonvulsant drug level increased 44.86 12.31 32 65647 1514 31630151
Respiratory failure 44.83 12.31 89 65590 101360 31530305
Diplopia 44.81 12.31 94 65585 14068 31617597
Cleft palate 44.37 12.31 23 65656 605 31631060
Chronic obstructive pulmonary disease 44.34 12.31 19 65660 45147 31586518
Renal failure 44.22 12.31 121 65558 123209 31508456
Foetal anticonvulsant syndrome 42.96 12.31 28 65651 1141 31630524
Off label use 42.08 12.31 489 65190 346785 31284880
Dyspnoea exertional 42.02 12.31 14 65665 38823 31592842
Strabismus 41.52 12.31 31 65648 1575 31630090
Herpes zoster 41.40 12.31 8 65671 31985 31599680
Retinal pigment epitheliopathy 41.04 12.31 16 65663 209 31631456
Memory impairment 40.88 12.31 172 65507 37958 31593707
Delusion 40.75 12.31 82 65597 11915 31619750
Staring 40.64 12.31 29 65650 1373 31630292
Dyspraxia 40.50 12.31 19 65660 400 31631265
Hypotonia 40.27 12.31 61 65618 7072 31624593
Fatigue 39.84 12.31 474 65205 334732 31296933
Decreased appetite 39.61 12.31 173 65506 153044 31478621
Dysarthria 39.59 12.31 151 65528 31866 31599799
Microcephaly 39.15 12.31 23 65656 777 31630888
Haemorrhage 38.95 12.31 25 65654 47309 31584356
Eyelid erosion 38.91 12.31 8 65671 3 31631662
Chest pain 38.82 12.31 119 65560 116838 31514827
Nasal septum disorder 38.80 12.31 11 65668 47 31631618
Arthropathy 38.42 12.31 3 65676 24048 31607617
Anticonvulsant drug level decreased 38.35 12.31 25 65654 1019 31630646
Epistaxis 38.22 12.31 33 65646 53674 31577991
Deep vein thrombosis 37.81 12.31 42 65637 60694 31570971
COVID-19 37.44 12.31 35 65644 54786 31576879
Logorrhoea 37.34 12.31 34 65645 2285 31629380
Wrong schedule 37.05 12.31 14 65665 167 31631498
Septic shock 36.71 12.31 50 65629 66108 31565557
Hallucination, auditory 36.62 12.31 72 65607 10288 31621377
Rash morbilliform 36.28 12.31 36 65643 2695 31628970
Depressive symptom 36.02 12.31 32 65647 2082 31629583
Abulia 36.00 12.31 19 65660 519 31631146
Tonic clonic movements 35.49 12.31 23 65656 928 31630737
Respiratory acidosis 35.46 12.31 46 65633 4616 31627049
Drug titration error 35.30 12.31 18 65661 457 31631208
Coarctation of the aorta 35.30 12.31 18 65661 457 31631208
Haematochezia 35.21 12.31 20 65659 40444 31591221
Cleft lip and palate 35.19 12.31 18 65661 460 31631205
Pneumonitis 35.05 12.31 10 65669 30642 31601023
Motor developmental delay 35.02 12.31 20 65659 640 31631025
Congenital diaphragmatic hernia 34.84 12.31 15 65664 256 31631409
Chapped lips 34.77 12.31 18 65661 472 31631193
Body dysmorphic disorder 34.67 12.31 12 65667 109 31631556
Tic 34.58 12.31 30 65649 1891 31629774
Rash erythematous 34.21 12.31 114 65565 22513 31609152
Psychomotor skills impaired 33.95 12.31 37 65642 3090 31628575
Cardiac septal hypertrophy 33.86 12.31 15 65664 275 31631390
Parasomnia 33.30 12.31 16 65663 356 31631309
Angina pectoris 33.29 12.31 10 65669 29631 31602034
Productive cough 33.09 12.31 14 65665 33526 31598139
Arthritis 33.09 12.31 8 65671 27377 31604288
Polydactyly 33.01 12.31 24 65655 1170 31630495
Pulmonary hypoplasia 33.01 12.31 17 65662 441 31631224
Educational problem 32.97 12.31 18 65661 527 31631138
Rectal haemorrhage 32.97 12.31 17 65662 36287 31595378
Abdominal pain upper 32.93 12.31 51 65628 63951 31567714
Chills 32.79 12.31 65 65614 74085 31557580
Postictal paralysis 32.73 12.31 14 65665 235 31631430
Suspiciousness 32.58 12.31 15 65664 302 31631363
Change in seizure presentation 32.58 12.31 11 65668 92 31631573
Burnout syndrome 32.23 12.31 12 65667 137 31631528
Paranoia 32.17 12.31 69 65610 10486 31621179
Face oedema 31.90 12.31 69 65610 10547 31621118
Personality disorder 31.77 12.31 23 65656 1114 31630551
Atonic seizures 31.64 12.31 14 65665 256 31631409
Blood creatine phosphokinase increased 31.63 12.31 171 65508 41803 31589862
Limb reduction defect 31.44 12.31 14 65665 260 31631405
Retrognathia 31.06 12.31 14 65665 268 31631397
Neonatal respiratory arrest 30.92 12.31 8 65671 22 31631643
Poisoning deliberate 30.90 12.31 55 65624 7289 31624376
Anxiety 30.78 12.31 306 65373 90727 31540938
Speech disorder 30.63 12.31 115 65564 24086 31607579
Anticonvulsant drug level below therapeutic 30.35 12.31 18 65661 619 31631046
Psoriatic arthropathy 30.35 12.31 3 65676 19880 31611785
Eye discharge 30.30 12.31 27 65652 1764 31629901
Affective disorder 30.21 12.31 38 65641 3698 31627967
Contraindicated product administered 30.14 12.31 3 65676 19769 31611896
Epidermal necrosis 29.99 12.31 16 65663 447 31631218
Haematuria 29.97 12.31 31 65648 46283 31585382
Angular cheilitis 29.90 12.31 12 65667 170 31631495
Illusion 29.85 12.31 19 65660 743 31630922
Catatonia 29.81 12.31 43 65636 4771 31626894
Cryptorchism 29.80 12.31 28 65651 1959 31629706
Intentional product use issue 29.76 12.31 35 65644 49312 31582353
Sinus tachycardia 29.65 12.31 86 65593 15763 31615902
Depressed level of consciousness 29.59 12.31 158 65521 38443 31593222
Upper gastrointestinal haemorrhage 29.57 12.31 6 65673 23177 31608488
Lung disorder 29.53 12.31 15 65664 32297 31599368
Major depression 29.33 12.31 40 65639 4213 31627452
Drug resistance 29.31 12.31 111 65568 23342 31608323
Affect lability 29.23 12.31 36 65643 3429 31628236
Hypernatraemia 29.22 12.31 55 65624 7608 31624057
Dysmetria 29.20 12.31 16 65663 472 31631193
Encephalopathy 29.17 12.31 139 65540 32335 31599330
Erythema of eyelid 29.11 12.31 19 65660 776 31630889
Suspected suicide 28.89 12.31 39 65640 4068 31627597
Haemangioma congenital 28.86 12.31 16 65663 483 31631182
Syncope 28.73 12.31 86 65593 85096 31546569
Musculoskeletal pain 28.56 12.31 13 65666 29815 31601850
Eosinophil percentage increased 28.48 12.31 16 65663 496 31631169
Convulsive threshold lowered 28.39 12.31 16 65663 499 31631166
Developmental regression 28.26 12.31 8 65671 34 31631631
Drug level decreased 28.22 12.31 51 65628 6839 31624826
Temperature regulation disorder 28.14 12.31 17 65662 605 31631060
Colitis 27.74 12.31 18 65661 33869 31597796
Bicuspid aortic valve 27.60 12.31 12 65667 210 31631455
Skin erosion 27.54 12.31 26 65653 1830 31629835
Lymphadenopathy 27.35 12.31 117 65562 26004 31605661
Thrombocytopenia 26.99 12.31 179 65500 142568 31489097
Enanthema 26.84 12.31 14 65665 373 31631292
Delirium 26.78 12.31 162 65517 41259 31590406
Cerebral ventricle dilatation 26.74 12.31 19 65660 893 31630772
Tongue movement disturbance 26.69 12.31 9 65670 75 31631590
Altered state of consciousness 26.61 12.31 100 65579 20951 31610714
Pilonidal cyst congenital 26.61 12.31 7 65672 21 31631644
Caesarean section 26.61 12.31 26 65653 1910 31629755
Cytomegalovirus infection 26.56 12.31 9 65670 24698 31606967
Hypoglycaemia neonatal 26.51 12.31 25 65654 1757 31629908
Derealisation 26.50 12.31 16 65663 569 31631096
Haemoptysis 26.48 12.31 17 65662 32172 31599493
Muscle twitching 26.47 12.31 55 65624 8175 31623490
Pulmonary oedema 26.37 12.31 32 65647 44470 31587195
Suicide threat 26.37 12.31 7 65672 22 31631643
Hypomagnesaemia 26.34 12.31 4 65675 19054 31612611
Renal aplasia 26.25 12.31 17 65662 685 31630980
Mucosal erosion 26.25 12.31 18 65661 799 31630866
Cleft lip 26.12 12.31 13 65666 313 31631352
Heart rate decreased 26.02 12.31 13 65666 28253 31603412
Drooling 25.86 12.31 32 65647 3063 31628602
Intellectual disability 25.85 12.31 21 65658 1208 31630457
Mental disorder 25.82 12.31 75 65604 13759 31617906
Nasopharyngitis 25.81 12.31 58 65621 63187 31568478
Tonic convulsion 25.80 12.31 20 65659 1075 31630590
Chest discomfort 25.72 12.31 39 65640 49330 31582335
False positive investigation result 25.71 12.31 13 65666 324 31631341
Insomnia 25.68 12.31 305 65374 94531 31537134
Peripheral circulatory failure 25.56 12.31 10 65669 132 31631533
Gait disturbance 25.47 12.31 259 65420 77236 31554429
Pancytopenia 25.43 12.31 94 65585 87222 31544443
Plagiocephaly 25.26 12.31 15 65664 517 31631148
Psoriasis 25.22 12.31 36 65643 46683 31584982
Apnoea 25.10 12.31 46 65633 6236 31625429
Large for dates baby 24.86 12.31 18 65661 872 31630793
Ischaemic stroke 24.79 12.31 3 65676 16968 31614697
Gout 24.70 12.31 4 65675 18170 31613495
Hyperhomocysteinaemia 24.67 12.31 11 65668 205 31631460
Madarosis 24.67 12.31 11 65668 205 31631460
Irregular sleep phase 24.57 12.31 8 65671 59 31631606
Hyperexplexia 24.49 12.31 7 65672 31 31631634
Blood pressure increased 24.34 12.31 84 65595 79549 31552116
Mental impairment 24.24 12.31 58 65621 9474 31622191
Erythema 24.20 12.31 264 65415 80141 31551524
Altered pitch perception 24.20 12.31 6 65673 13 31631652
Pulmonary fibrosis 24.20 12.31 3 65676 16657 31615008
Epispadias 24.10 12.31 10 65669 155 31631510
Hypertonia 23.93 12.31 35 65644 3933 31627732
Cerebral infarction 23.83 12.31 12 65667 25965 31605700
Salivary hypersecretion 23.81 12.31 51 65628 7741 31623924
Congenital melanocytic naevus 23.60 12.31 6 65673 15 31631650
Serotonin syndrome 23.58 12.31 89 65590 18684 31612981
Posture abnormal 23.42 12.31 25 65654 2039 31629626
Lung neoplasm malignant 23.39 12.31 3 65676 16227 31615438
Confusional state 23.31 12.31 397 65282 132937 31498728
Cardio-respiratory arrest 23.21 12.31 185 65494 51541 31580124
Postictal state 22.98 12.31 16 65663 728 31630937
Emotional disorder 22.98 12.31 40 65639 5209 31626456
Disturbance in social behaviour 22.97 12.31 23 65656 1740 31629925
Developmental coordination disorder 22.95 12.31 10 65669 176 31631489
Gambling disorder 22.93 12.31 22 65657 1580 31630085
Language disorder 22.84 12.31 25 65654 2098 31629567
Movement disorder 22.78 12.31 62 65617 10957 31620708
Blood creatinine increased 22.73 12.31 101 65578 88977 31542688
Cardiogenic shock 22.68 12.31 9 65670 22399 31609266
Osteonecrosis of jaw 22.66 12.31 4 65675 17067 31614598
Product dispensing error 22.56 12.31 42 65637 5762 31625903
Pyloric stenosis 22.52 12.31 16 65663 752 31630913
Transferrin increased 22.45 12.31 5 65674 5 31631660
Cheilitis 22.41 12.31 25 65654 2143 31629522
Pyramidal tract syndrome 22.35 12.31 10 65669 188 31631477
Cerebral haemorrhage 22.33 12.31 21 65658 32791 31598874
Disorientation 22.32 12.31 124 65555 30620 31601045
Mucosal inflammation 22.32 12.31 23 65656 34404 31597261
Spina bifida 22.27 12.31 12 65667 342 31631323
Papule 22.25 12.31 31 65648 3331 31628334
Cataplexy 22.11 12.31 12 65667 347 31631318
Melaena 22.11 12.31 21 65658 32633 31599032
Exposure via ingestion 22.05 12.31 24 65655 2001 31629664
Feelings of worthlessness 22.02 12.31 11 65668 267 31631398
Intelligence test abnormal 21.89 12.31 6 65673 22 31631643
Hyperglycaemia 21.86 12.31 26 65653 36450 31595215
Constipation 21.69 12.31 159 65520 123832 31507833
Neurological decompensation 21.69 12.31 27 65652 2600 31629065
Coordination abnormal 21.63 12.31 47 65632 7204 31624461
Blood pressure fluctuation 21.62 12.31 10 65669 22726 31608939
Bacteraemia 21.60 12.31 5 65674 17629 31614036
Ear disorder 21.55 12.31 20 65659 1377 31630288
Congenital genital malformation male 21.54 12.31 5 65674 7 31631658
Product use in unapproved indication 21.54 12.31 119 65560 99052 31532613
Depersonalisation/derealisation disorder 21.45 12.31 14 65665 572 31631093
Distributive shock 21.41 12.31 18 65661 1087 31630578
Oral disorder 21.35 12.31 33 65646 3894 31627771
Congenital astigmatism 21.29 12.31 6 65673 25 31631640
Wheezing 21.19 12.31 26 65653 35960 31595705
Compulsive shopping 20.87 12.31 12 65667 389 31631276
Muscle rigidity 20.77 12.31 56 65623 9841 31621824
Neoplasm progression 20.75 12.31 8 65671 20264 31611401
Skin malformation 20.73 12.31 4 65675 0 31631665
Mucosal exfoliation 20.73 12.31 4 65675 0 31631665
Hyperbilirubinaemia neonatal 20.71 12.31 15 65664 727 31630938
Aphasia 20.65 12.31 89 65590 19842 31611823
Wrong product administered 20.64 12.31 37 65642 4931 31626734
International normalised ratio increased 20.54 12.31 39 65640 45184 31586481
Drug withdrawal convulsions 20.54 12.31 18 65661 1150 31630515
Impulsive behaviour 20.44 12.31 23 65656 1990 31629675
Cardiac disorder 20.40 12.31 31 65648 39183 31592482
Laryngomalacia 20.40 12.31 11 65668 314 31631351
Influenza 20.33 12.31 38 65641 44287 31587378
Obsessive thoughts 20.26 12.31 14 65665 629 31631036
Dyslexia 20.12 12.31 11 65668 323 31631342
Deja vu 20.11 12.31 5 65674 11 31631654
Hepatic cirrhosis 20.11 12.31 4 65675 15670 31615995
Scab 19.95 12.31 33 65646 4122 31627543
Hallucination, visual 19.94 12.31 75 65604 15719 31615946
Skin exfoliation 19.87 12.31 100 65579 23774 31607891
Wrong patient 19.84 12.31 9 65670 175 31631490
Cytokine release syndrome 19.84 12.31 5 65674 16637 31615028
Hypoxia 19.83 12.31 47 65632 50266 31581399
Mood swings 19.78 12.31 46 65633 7378 31624287
Brain malformation 19.76 12.31 8 65671 116 31631549
Aplasia cutis congenita 19.70 12.31 8 65671 117 31631548
Diverticulitis 19.68 12.31 7 65672 18638 31613027
Blood glucose increased 19.65 12.31 63 65616 61020 31570645
Opsoclonus myoclonus 19.63 12.31 7 65672 70 31631595
Restless legs syndrome 19.52 12.31 47 65632 7709 31623956
Blood potassium increased 19.51 12.31 4 65675 15341 31616324
Peritonitis 19.48 12.31 4 65675 15323 31616342
Myalgia 19.47 12.31 88 65591 77170 31554495
Distractibility 19.46 12.31 11 65668 345 31631320
Lethargy 19.46 12.31 142 65537 38499 31593166
Akathisia 19.39 12.31 45 65634 7208 31624457
Epileptic aura 19.26 12.31 5 65674 14 31631651
Congenital cerebral cyst 19.26 12.31 5 65674 14 31631651
Potter's syndrome 19.26 12.31 5 65674 14 31631651
Bundle branch block right 19.24 12.31 44 65635 6980 31624685
Drug screen false positive 19.14 12.31 14 65665 689 31630976
Sinusitis 19.10 12.31 29 65650 36667 31594998
Gangrene neonatal 19.08 12.31 9 65670 192 31631473
Pneumocystis jirovecii pneumonia 19.02 12.31 7 65672 18244 31613421
Snoring 18.99 12.31 27 65652 2956 31628709
Bone marrow failure 18.98 12.31 18 65661 27990 31603675
Congenital hand malformation 18.96 12.31 13 65666 577 31631088
Subgaleal haematoma 18.82 12.31 6 65673 41 31631624
Transverse presentation 18.80 12.31 7 65672 80 31631585
Increased appetite 18.79 12.31 41 65638 6303 31625362
Abdominal distension 18.69 12.31 49 65630 50635 31581030
Cross sensitivity reaction 18.62 12.31 18 65661 1305 31630360
Mental status changes 18.58 12.31 133 65546 35835 31595830
Withdrawal syndrome 18.57 12.31 60 65619 11657 31620008
Anal atresia 18.56 12.31 10 65669 285 31631380
Mouth ulceration 18.53 12.31 57 65622 10791 31620874
Developmental hip dysplasia 18.50 12.31 10 65669 287 31631378
Ocular hyperaemia 18.42 12.31 54 65625 9955 31621710
Single umbilical artery 18.42 12.31 9 65670 208 31631457
Bladder cancer 18.39 12.31 4 65675 14721 31616944
Skin degenerative disorder 18.31 12.31 5 65674 18 31631647
Psychiatric symptom 18.24 12.31 28 65651 3283 31628382
Abdominal discomfort 18.15 12.31 51 65628 51516 31580149
Blood urea increased 18.12 12.31 20 65659 28992 31602673
Teratogenicity 18.11 12.31 6 65673 47 31631618
Genital erosion 18.11 12.31 9 65670 216 31631449
Myocardial ischaemia 18.04 12.31 6 65673 16661 31615004
Cerebellar atrophy 18.02 12.31 12 65667 507 31631158
Joint laxity 18.00 12.31 11 65668 400 31631265
Vesicoureteric reflux 17.95 12.31 8 65671 149 31631516
Fluid retention 17.93 12.31 15 65664 24787 31606878
Colitis ulcerative 17.85 12.31 8 65671 18521 31613144
Muscle tone disorder 17.85 12.31 8 65671 151 31631514
Full blood count decreased 17.82 12.31 6 65673 16534 31615131
Subacute cutaneous lupus erythematosus 17.79 12.31 15 65664 909 31630756
Feeling drunk 17.77 12.31 20 65659 1731 31629934
Bone pain 17.66 12.31 9 65670 19342 31612323
Congenital eyelid malformation 17.65 12.31 7 65672 96 31631569
Oral mucosal erythema 17.61 12.31 11 65668 416 31631249
Tongue biting 17.61 12.31 14 65665 781 31630884
Persecutory delusion 17.57 12.31 23 65656 2329 31629336
Lennox-Gastaut syndrome 17.48 12.31 6 65673 53 31631612
Multiple congenital abnormalities 17.47 12.31 12 65667 534 31631131
Renal disorder 17.47 12.31 14 65665 23631 31608034
Neonatal disorder 17.44 12.31 14 65665 792 31630873
Suicidal behaviour 17.42 12.31 18 65661 1414 31630251
Clostridium difficile infection 17.39 12.31 7 65672 17272 31614393
Weight decrease neonatal 17.37 12.31 10 65669 325 31631340
Clostridium difficile colitis 17.19 12.31 4 65675 14052 31617613
Hypercalcaemia 17.09 12.31 4 65675 13996 31617669
Dehydration 17.08 12.31 161 65518 118950 31512715
Tongue eruption 17.07 12.31 4 65675 6 31631659
Meningeal disorder 17.07 12.31 10 65669 336 31631329
Oculomucocutaneous syndrome 17.03 12.31 8 65671 169 31631496
Acute coronary syndrome 16.97 12.31 3 65676 12786 31618879
Newborn persistent pulmonary hypertension 16.96 12.31 7 65672 107 31631558
Treatment noncompliance 16.95 12.31 101 65578 25583 31606082
Transaminases increased 16.89 12.31 97 65582 24244 31607421
Differential white blood cell count abnormal 16.87 12.31 17 65662 1296 31630369
Metastases to liver 16.85 12.31 3 65676 12724 31618941
Parkinsonism 16.83 12.31 44 65635 7592 31624073
Feeling jittery 16.81 12.31 29 65650 3748 31627917
Hyperkinesia 16.79 12.31 19 65660 1654 31630011
Intraventricular haemorrhage neonatal 16.78 12.31 9 65670 254 31631411
Congenital genital malformation 16.73 12.31 7 65672 111 31631554
Anaphylactic reaction 16.73 12.31 22 65657 29531 31602134
Hypokalaemia 16.71 12.31 56 65623 53518 31578147
Hypermobility syndrome 16.70 12.31 10 65669 350 31631315
Dyspepsia 16.68 12.31 26 65653 32527 31599138
Kidney malformation 16.57 12.31 8 65671 180 31631485
Respiratory arrest 16.53 12.31 102 65577 26155 31605510
Cataract 16.48 12.31 15 65664 23792 31607873
Fallot's tetralogy 16.45 12.31 8 65671 183 31631482
Eyelid oedema 16.43 12.31 33 65646 4787 31626878
Blood pressure systolic increased 16.40 12.31 10 65669 19460 31612205
Sleep disorder 16.37 12.31 102 65577 26246 31605419
Positive end-expiratory pressure 16.35 12.31 4 65675 8 31631657
Depressed mood 16.34 12.31 76 65603 17499 31614166
Hyperreflexia 16.34 12.31 25 65654 2924 31628741
Product name confusion 16.32 12.31 6 65673 66 31631599
Oesophagitis 16.28 12.31 3 65676 12413 31619252
Urinary tract infection 16.27 12.31 93 65586 76776 31554889
Prostatic specific antigen increased 16.27 12.31 4 65675 13534 31618131
Temporal lobe epilepsy 16.25 12.31 8 65671 188 31631477
Thrombocytopenia neonatal 16.20 12.31 10 65669 370 31631295
SJS-TEN overlap 16.20 12.31 9 65670 273 31631392
Chronic kidney disease 16.17 12.31 34 65645 37941 31593724
Foetal distress syndrome 16.16 12.31 15 65664 1033 31630632
Wrong patient received product 16.05 12.31 23 65656 2536 31629129
Rash macular 15.98 12.31 56 65623 11339 31620326
Pulmonary hypertension 15.92 12.31 11 65668 20030 31611635
Chordee 15.85 12.31 6 65673 72 31631593
Cellulitis 15.81 12.31 49 65630 47969 31583696
Cerebellar syndrome 15.78 12.31 21 65658 2160 31629505
Dysgraphia 15.77 12.31 21 65658 2162 31629503
Enuresis 15.76 12.31 21 65658 2163 31629502
Candida infection 15.70 12.31 7 65672 16251 31615414
Localised infection 15.66 12.31 6 65673 15259 31616406
Thrombosis 15.64 12.31 45 65634 45106 31586559
Pulmonary valve stenosis congenital 15.62 12.31 7 65672 132 31631533
Neoplasm malignant 15.57 12.31 10 65669 18921 31612744
Metabolic myopathy 15.54 12.31 3 65676 0 31631665
Encephalocele 15.54 12.31 3 65676 0 31631665
Rubella 15.54 12.31 3 65676 0 31631665
Sopor 15.54 12.31 56 65623 11496 31620169
Economic problem 15.50 12.31 16 65663 1255 31630410
Torticollis 15.41 12.31 15 65664 1097 31630568
Congenital central nervous system anomaly 15.39 12.31 11 65668 522 31631143
Congenital scoliosis 15.28 12.31 6 65673 80 31631585
Inappropriate schedule of product administration 15.26 12.31 54 65625 50769 31580896
Monorchidism 15.21 12.31 4 65675 12 31631653
Rash papular 15.18 12.31 45 65634 8347 31623318
Drug intolerance 15.15 12.31 56 65623 51977 31579688
Congenital vas deferens absence 15.11 12.31 5 65674 39 31631626
Congenital muscle absence 15.11 12.31 5 65674 39 31631626
Pustule 15.11 12.31 9 65670 312 31631353
Hyperphagia 15.02 12.31 16 65663 1302 31630363
Extrapyramidal disorder 14.92 12.31 56 65623 11722 31619943
Hypertelorism 14.87 12.31 11 65668 551 31631114
Circadian rhythm sleep disorder 14.78 12.31 10 65669 434 31631231
Acute respiratory failure 14.77 12.31 22 65657 28033 31603632
Lip oedema 14.74 12.31 21 65658 2303 31629362
Asterixis 14.74 12.31 15 65664 1157 31630508
Hypothermia neonatal 14.70 12.31 6 65673 89 31631576
Drop attacks 14.69 12.31 11 65668 561 31631104
Dermatitis allergic 14.68 12.31 36 65643 5973 31625692
Aspergillus infection 14.67 12.31 3 65676 11525 31620140
Nasal disorder 14.59 12.31 18 65661 1717 31629948
Idiopathic generalised epilepsy 14.59 12.31 5 65674 44 31631621
Agoraphobia 14.57 12.31 8 65671 237 31631428
Cerebral atrophy 14.54 12.31 29 65650 4186 31627479
Hepatotoxicity 14.54 12.31 11 65668 19115 31612550
Congenital inguinal hernia 14.52 12.31 7 65672 157 31631508
Judgement impaired 14.34 12.31 11 65668 582 31631083
Fontanelle bulging 14.32 12.31 4 65675 16 31631649
Conversion disorder 14.30 12.31 9 65670 345 31631320
Delusional perception 14.24 12.31 7 65672 164 31631501
Skin turgor decreased 14.23 12.31 10 65669 462 31631203
Arthropod sting 14.21 12.31 9 65670 349 31631316
Limited symptom panic attack 14.11 12.31 5 65674 49 31631616
Prominent epicanthal folds 14.09 12.31 7 65672 168 31631497
Hypoglycaemia 14.08 12.31 56 65623 50890 31580775
Laboratory test abnormal 14.07 12.31 11 65668 18803 31612862
Angina unstable 14.06 12.31 3 65676 11192 31620473
Peripheral artery thrombosis 14.05 12.31 20 65659 2192 31629473
Moaning 13.99 12.31 12 65667 745 31630920
Transient tachypnoea of the newborn 13.97 12.31 7 65672 171 31631494
Caudal regression syndrome 13.93 12.31 5 65674 51 31631614
Loss of employment 13.93 12.31 10 65669 478 31631187
Conjunctival irritation 13.90 12.31 6 65673 103 31631562
Sweat gland disorder 13.90 12.31 6 65673 103 31631562
Swelling 13.86 12.31 36 65643 37322 31594343
Exomphalos 13.79 12.31 7 65672 176 31631489
Double outlet right ventricle 13.65 12.31 6 65673 108 31631557
Hospitalisation 13.61 12.31 55 65624 49752 31581913
Postmature baby 13.60 12.31 4 65675 20 31631645
Somnolence neonatal 13.60 12.31 4 65675 20 31631645
Tooth malformation 13.51 12.31 7 65672 184 31631481
Congenital knee deformity 13.50 12.31 6 65673 111 31631554
Trichiasis 13.47 12.31 3 65676 3 31631662
Hypothermia 13.47 12.31 47 65632 9497 31622168
Automatism 13.45 12.31 6 65673 112 31631553
Epidermolysis 13.31 12.31 8 65671 282 31631383
Visual field defect 13.30 12.31 28 65651 4200 31627465
Grimacing 13.29 12.31 8 65671 283 31631382
Renal tubular necrosis 13.26 12.31 7 65672 14752 31616913
Hepatocellular injury 13.13 12.31 83 65596 21461 31610204
Heart disease congenital 13.13 12.31 15 65664 1320 31630345
Gastric ulcer 13.07 12.31 7 65672 14627 31617038
Nephritis allergic 13.05 12.31 9 65670 403 31631262
Congenital myopia 12.92 12.31 5 65674 64 31631601
Live birth 12.91 12.31 7 65672 202 31631463
Dysphoria 12.87 12.31 19 65660 2153 31629512
Congenital aortic atresia 12.85 12.31 4 65675 25 31631640
Hyperpyrexia 12.80 12.31 20 65659 2381 31629284
Symblepharon 12.80 12.31 6 65673 126 31631539
Abortion induced 12.76 12.31 6 65673 127 31631538
Psychotic symptom 12.73 12.31 16 65663 1556 31630109
Maternal exposure before pregnancy 12.72 12.31 11 65668 690 31630975
Cholelithiasis 12.64 12.31 13 65666 19466 31612199
Crystal urine present 12.57 12.31 9 65670 428 31631237
Coronary artery occlusion 12.56 12.31 3 65676 10353 31621312
Bronchiolitis 12.54 12.31 22 65657 2882 31628783
Generalised anxiety disorder 12.54 12.31 11 65668 704 31630961
Heart rate irregular 12.52 12.31 7 65672 14282 31617383
Bipolar II disorder 12.47 12.31 4 65675 28 31631637
Eosinophil count increased 12.44 12.31 40 65639 7751 31623914
Product quality issue 12.38 12.31 66 65613 16045 31615620
Injection site pain 12.38 12.31 34 65645 34600 31597065
Drug ineffective 12.35 12.31 965 64714 394608 31237057
Ligament laxity 12.34 12.31 4 65675 29 31631636
Meconium in amniotic fluid 12.34 12.31 4 65675 29 31631636
Terminal insomnia 12.32 12.31 9 65670 442 31631223

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 3195.48 11.55 2770 144727 175192 70605755
Drug reaction with eosinophilia and systemic symptoms 2118.93 11.55 1384 146113 56629 70724318
Completed suicide 1952.01 11.55 2379 145118 224756 70556191
Epilepsy 1646.73 11.55 1018 146479 37766 70743181
Stevens-Johnson syndrome 1623.03 11.55 981 146516 34926 70746021
Toxicity to various agents 1510.61 11.55 2781 144716 379391 70401556
Generalised tonic-clonic seizure 1095.76 11.55 813 146684 40848 70740099
Intentional overdose 1004.72 11.55 1128 146369 97307 70683640
Toxic epidermal necrolysis 727.71 11.55 626 146871 38931 70742016
Suicide attempt 711.86 11.55 852 146645 78658 70702289
Ataxia 671.36 11.55 480 147017 22737 70758210
Status epilepticus 649.99 11.55 481 147016 24045 70756902
Drug level increased 569.23 11.55 526 146971 35943 70745004
Product substitution issue 568.27 11.55 397 147100 18116 70762831
Aggression 545.57 11.55 585 146912 47861 70733086
Drug interaction 539.57 11.55 1880 145617 379561 70401386
Overdose 508.61 11.55 1103 146394 168642 70612305
Exposure during pregnancy 485.39 11.55 744 146753 86973 70693974
Somnolence 484.25 11.55 1252 146245 214354 70566593
Rheumatoid arthritis 467.42 11.55 37 147460 291768 70489179
Agitation 419.98 11.55 721 146776 92654 70688293
Intentional self-injury 395.28 11.55 404 147093 31246 70749701
Suicidal ideation 383.11 11.55 589 146908 69007 70711940
Petit mal epilepsy 382.91 11.55 199 147298 5245 70775702
Nystagmus 370.12 11.55 235 147262 9120 70771827
Rash maculo-papular 354.60 11.55 480 147017 50065 70730882
Diarrhoea 348.40 11.55 691 146806 782650 69998297
Dyspnoea 340.11 11.55 682 146815 769378 70011569
Coma 332.89 11.55 646 146851 91198 70689749
Rash 330.60 11.55 1999 145498 508563 70272384
Mania 324.29 11.55 276 147221 16898 70764049
Arthralgia 310.64 11.55 354 147143 503036 70277911
Pneumonia 308.25 11.55 478 147019 595754 70185193
Irritability 295.89 11.55 381 147116 37844 70743103
Partial seizures 294.78 11.55 194 147303 8011 70772936
Joint swelling 267.79 11.55 96 147401 253115 70527832
Tremor 267.77 11.55 821 146676 154803 70626144
Infusion related reaction 260.17 11.55 48 147449 197486 70583461
Focal dyscognitive seizures 257.93 11.55 131 147366 3286 70777661
Lymphadenopathy 257.38 11.55 405 147092 48386 70732561
Pain 253.06 11.55 586 146911 628230 70152717
Synovitis 244.05 11.55 5 147492 129223 70651724
Febrile neutropenia 244 11.55 62 147435 204256 70576691
Sudden unexplained death in epilepsy 238.75 11.55 78 147419 580 70780367
Arthropathy 237.39 11.55 20 147477 150037 70630910
Abnormal behaviour 236.42 11.55 325 147172 34384 70746563
Serotonin syndrome 231.08 11.55 356 147141 41758 70739189
Anaemia 230.38 11.55 301 147196 403122 70377825
Bipolar disorder 228.42 11.55 161 147336 7447 70773500
Oral mucosa erosion 227.60 11.55 98 147399 1667 70779280
Haemophagocytic lymphohistiocytosis 226.29 11.55 240 147257 19372 70761575
Electrocardiogram QRS complex prolonged 217.37 11.55 173 147324 9633 70771314
Contraindicated product administered 212.77 11.55 18 147479 134594 70646353
Obsessive-compulsive disorder 212.68 11.55 135 147362 5235 70775712
Peripheral swelling 211.74 11.55 114 147383 236449 70544498
Drug eruption 209.90 11.55 329 147168 39167 70741780
Diplopia 207.62 11.55 274 147223 27873 70753074
Myoclonus 206.00 11.55 264 147233 26091 70754856
Abortion spontaneous 198.78 11.55 260 147237 26219 70754728
Multiple-drug resistance 198.74 11.55 146 147351 7209 70773738
Depression 188.81 11.55 867 146630 198107 70582840
Pain in extremity 182.91 11.55 249 147248 327833 70453114
Poisoning 182.17 11.55 230 147267 22392 70758555
Disturbance in attention 182.02 11.55 323 147174 42571 70738376
Lip erosion 179.62 11.55 77 147420 1295 70779652
Atrial fibrillation 178.31 11.55 80 147417 184268 70596679
Myoclonic epilepsy 175.21 11.55 83 147414 1781 70779166
Nasopharyngitis 172.73 11.55 126 147371 222080 70558867
Anticonvulsant drug level decreased 172.02 11.55 82 147415 1785 70779162
Cognitive disorder 166.38 11.55 382 147115 60574 70720373
Foetal exposure during pregnancy 166.10 11.55 118 147379 5527 70775420
Cardiac failure congestive 165.77 11.55 39 147458 135418 70645529
Conjunctival hyperaemia 164.85 11.55 104 147393 3989 70776958
Brugada syndrome 163.60 11.55 68 147429 1055 70779892
Erythema multiforme 160.51 11.55 185 147312 16379 70764568
Acute kidney injury 160.40 11.55 482 147015 474142 70306805
Psychotic disorder 160.09 11.55 284 147213 37417 70743530
Anticonvulsant drug level above therapeutic 156.44 11.55 66 147431 1065 70779882
Anxiety 153.78 11.55 881 146616 219449 70561498
Malignant neoplasm progression 149.07 11.55 35 147462 121704 70659243
Rash morbilliform 149.01 11.55 109 147388 5346 70775601
Neuroleptic malignant syndrome 147.10 11.55 223 147274 25784 70755163
Oculogyric crisis 146.25 11.55 83 147414 2615 70778332
Disease progression 145.33 11.55 72 147425 156600 70624347
Tardive dyskinesia 144.85 11.55 138 147359 9791 70771156
Swelling 142.54 11.55 110 147387 188429 70592518
Myocardial infarction 141.81 11.55 91 147406 171554 70609393
Aura 139.30 11.55 57 147440 848 70780099
Anticonvulsant drug level increased 138.87 11.55 78 147419 2408 70778539
Accidental exposure to product by child 137.93 11.55 81 147416 2725 70778222
Hyperreflexia 137.22 11.55 118 147379 7324 70773623
Electroencephalogram abnormal 136.74 11.55 102 147395 5156 70775791
Infection 134.33 11.55 144 147353 210641 70570306
Cough 133.93 11.55 299 147198 325078 70455869
Sinusitis 132.68 11.55 95 147402 169100 70611847
Cardio-respiratory arrest 131.22 11.55 484 147013 100193 70680754
Face oedema 129.91 11.55 209 147288 25430 70755517
Abdominal discomfort 129.85 11.55 153 147344 214505 70566442
Hypertension 128.51 11.55 264 147233 295769 70485178
Hypomania 127.95 11.55 104 147393 5968 70774979
Psychomotor hyperactivity 127.59 11.55 159 147338 15274 70765673
Gastrointestinal haemorrhage 126.15 11.55 64 147433 137344 70643603
Cardiac failure 125.71 11.55 71 147426 143470 70637477
Muscle rigidity 124.53 11.55 173 147324 18477 70762470
Back pain 122.68 11.55 236 147261 270916 70510031
Depressed level of consciousness 120.45 11.55 428 147069 87003 70693944
Extrapyramidal disorder 117.46 11.55 178 147319 20572 70760375
Clonus 116.82 11.55 100 147397 6168 70774779
Mood altered 116.31 11.55 157 147340 16318 70764629
Lower respiratory tract infection 115.56 11.55 44 147453 111869 70669078
Bipolar I disorder 114.89 11.55 63 147434 1854 70779093
Suspected suicide 112.50 11.55 114 147383 8720 70772227
Sepsis 110.47 11.55 213 147284 244332 70536615
Plasma cell myeloma 109.80 11.55 12 147485 73189 70707758
Vertigo 106.21 11.55 329 147168 62314 70718633
Partial seizures with secondary generalisation 105.94 11.55 42 147455 573 70780374
Anger 105.26 11.55 148 147349 15984 70764963
Pleurothotonus 105.13 11.55 64 147433 2302 70778645
Drug intolerance 105.08 11.55 193 147304 225494 70555453
Coronary artery disease 103.04 11.55 7 147490 62729 70718218
Death 102.59 11.55 631 146866 509430 70271517
Depressed mood 101.73 11.55 258 147239 43562 70737385
Haemoglobin decreased 100.44 11.55 170 147327 204989 70575958
Neuropathy peripheral 99.80 11.55 71 147426 126825 70654122
Blood pressure increased 99.09 11.55 149 147348 188368 70592579
Cross sensitivity reaction 98.42 11.55 71 147426 3407 70777540
Rash erythematous 97.49 11.55 282 147215 51436 70729511
Intentional product use issue 97.44 11.55 65 147432 120077 70660870
Suicidal behaviour 97.18 11.55 67 147430 2989 70777958
Balance disorder 96.19 11.55 407 147090 89721 70691226
Chest pain 96.06 11.55 240 147257 251020 70529927
Hyperkalaemia 95.82 11.55 51 147446 106540 70674407
Meningitis aseptic 95.13 11.55 90 147407 6329 70774618
Dystonia 94.91 11.55 157 147340 19549 70761398
Drug level decreased 94.80 11.55 124 147373 12500 70768447
Abortion induced 94.59 11.55 91 147406 6534 70774413
Fatigue 94.52 11.55 1180 146317 823139 69957808
Herpes zoster 94.03 11.55 30 147467 85205 70695742
Atonic seizures 93.87 11.55 41 147456 723 70780224
Dyskinesia 93.45 11.55 240 147257 40834 70740113
Akathisia 92.70 11.55 121 147376 12172 70768775
Arthritis 92.40 11.55 44 147453 97936 70683011
Hallucination, auditory 92.30 11.55 149 147348 18179 70762768
Mydriasis 92.04 11.55 139 147358 16014 70764933
Electrocardiogram QT prolonged 91.35 11.55 380 147117 83137 70697810
Memory impairment 90.22 11.55 407 147090 92234 70688713
Eosinophilia 90.09 11.55 234 147263 40085 70740862
Delusion 90.04 11.55 151 147346 19014 70761933
Maternal exposure during breast feeding 89.63 11.55 57 147440 2217 70778730
Restlessness 89.55 11.55 240 147257 41888 70739059
Musculoskeletal pain 89.19 11.55 38 147459 90289 70690658
Wound 89.10 11.55 47 147450 98685 70682262
Hyperthermia 88.73 11.55 139 147358 16532 70764415
Thinking abnormal 88.37 11.55 117 147380 11934 70769013
General physical health deterioration 88.25 11.55 228 147269 235803 70545144
Rash macular 88.01 11.55 176 147321 25368 70755579
Impaired healing 87.89 11.55 23 147474 74351 70706596
Behaviour disorder 87.52 11.55 80 147417 5384 70775563
Oedema peripheral 85.52 11.55 220 147277 227871 70553076
Respiratory arrest 84.79 11.55 276 147221 53657 70727290
Mobility decreased 84.50 11.55 55 147442 102944 70678003
Chronic obstructive pulmonary disease 84.46 11.55 28 147469 77613 70703334
Conjunctivitis 84.10 11.55 161 147336 22475 70758472
Altered state of consciousness 84.07 11.55 227 147270 39795 70741152
Discomfort 82.89 11.55 59 147438 105377 70675570
Dizziness 82.42 11.55 1389 146108 462752 70318195
Dyspnoea exertional 82.36 11.55 30 147467 78400 70702547
Cardiac arrest 82.33 11.55 592 146905 159242 70621705
Therapeutic product effect decreased 82.18 11.55 106 147391 142912 70638035
Tubulointerstitial nephritis and uveitis syndrome 80.69 11.55 29 147468 296 70780651
Mental disorder 80.39 11.55 180 147317 28060 70752887
Postictal psychosis 79.47 11.55 24 147473 133 70780814
Toxic skin eruption 79.38 11.55 147 147350 20015 70760932
Sopor 78.82 11.55 190 147307 31077 70749870
Apathy 78.81 11.55 110 147387 11798 70769149
Dysarthria 78.19 11.55 296 147201 62017 70718930
Cerebrovascular accident 77.72 11.55 111 147386 143359 70637588
Poisoning deliberate 76.95 11.55 132 147365 16928 70764019
Camptocormia 76.45 11.55 31 147466 450 70780497
Acute myocardial infarction 76.33 11.55 28 147469 72859 70708088
Muscle twitching 76.11 11.55 143 147354 19684 70761263
Ascites 75.89 11.55 23 147474 67524 70713423
Hypogammaglobulinaemia 75.50 11.55 106 147391 11432 70769515
Mood swings 75.38 11.55 136 147361 18150 70762797
Sinus tachycardia 74.92 11.55 196 147301 33717 70747230
Abdominal pain 72.52 11.55 416 147081 341711 70439236
Epileptic aura 72.16 11.55 19 147478 57 70780890
Asthenia 72.13 11.55 607 146890 457059 70323888
Crying 71.76 11.55 145 147352 21054 70759893
Infarction 71.66 11.55 64 147433 4178 70776769
Sedation 71.53 11.55 237 147260 46494 70734453
Rectal haemorrhage 71.15 11.55 24 147473 65807 70715140
Rash papular 70.73 11.55 132 147365 18078 70762869
Mental impairment 70.70 11.55 128 147369 17127 70763820
Interstitial lung disease 70.65 11.55 68 147429 104617 70676330
Cheilitis 69.65 11.55 67 147430 4810 70776137
Cerebellar syndrome 69.36 11.55 69 147428 5162 70775785
Eyelid erosion 69.12 11.55 18 147479 51 70780896
Antipsychotic drug level increased 68.91 11.55 70 147427 5370 70775577
Encephalopathy 68.56 11.55 282 147215 61379 70719568
Papule 68.55 11.55 77 147420 6626 70774321
Glossodynia 68.51 11.55 48 147449 86439 70694508
Alopecia 68.01 11.55 200 147297 198290 70582657
Renal impairment 67.93 11.55 122 147375 143815 70637132
Irritable bowel syndrome 67.66 11.55 12 147485 50838 70730109
Catatonia 67.56 11.55 84 147413 8049 70772898
Psychomotor retardation 67.23 11.55 70 147427 5528 70775419
Affective disorder 66.59 11.55 80 147417 7399 70773548
Gaze palsy 66.52 11.55 51 147446 2687 70778260
Bronchitis 66.22 11.55 88 147409 117155 70663792
Dehydration 65.69 11.55 245 147252 225897 70555050
Exposure via ingestion 65.48 11.55 65 147432 4850 70776097
Blepharospasm 64.93 11.55 58 147439 3787 70777160
Unresponsive to stimuli 64.58 11.55 246 147251 51685 70729262
Tic 64.41 11.55 50 147447 2683 70778264
Retinal pigment epitheliopathy 64.21 11.55 26 147471 376 70780571
Gastrointestinal disorder 63.86 11.55 75 147422 105352 70675595
Folliculitis 63.79 11.55 7 147490 42563 70738384
Renal failure 63.69 11.55 192 147305 188878 70592069
Mucosal disorder 63.67 11.55 53 147444 3145 70777802
Blood pressure systolic increased 63.43 11.55 20 147477 57239 70723708
Psoriatic arthropathy 62.75 11.55 28 147469 64743 70716204
Overweight 62.67 11.55 55 147442 3508 70777439
Pleural effusion 62.35 11.55 113 147384 132751 70648196
Parkinsonism 61.92 11.55 113 147384 15212 70765735
C-reactive protein abnormal 61.37 11.55 5 147492 38574 70742373
Productive cough 61.36 11.55 44 147453 78293 70702654
Pericarditis 60.75 11.55 52 147445 84653 70696294
Oral disorder 60.70 11.55 85 147412 9144 70771803
Paranoia 60.62 11.55 120 147377 17168 70763779
Exposure via breast milk 60.49 11.55 32 147465 875 70780072
Trichiasis 59.84 11.55 17 147480 73 70780874
Neutropenia 59.25 11.55 304 147193 256852 70524095
Systemic lupus erythematosus 59.07 11.55 75 147422 101827 70679120
Haematochezia 58.62 11.55 40 147457 73041 70707906
Lung disorder 58.50 11.55 36 147461 69448 70711499
Major depression 57.94 11.55 80 147417 8494 70772453
Logorrhoea 57.78 11.55 56 147441 4058 70776889
Blood pressure fluctuation 56.40 11.55 26 147471 58986 70721961
Pyrexia 56.15 11.55 1655 145842 605297 70175650
Neovascularisation 56.14 11.55 33 147464 1112 70779835
Fluid retention 55.98 11.55 31 147466 63354 70717593
Sleep disorder due to general medical condition, insomnia type 55.83 11.55 5 147492 35727 70745220
Pulmonary hypertension 55.73 11.55 14 147483 46522 70734425
Depressive symptom 55.54 11.55 61 147436 5120 70775827
Deep vein thrombosis 55.24 11.55 91 147406 110951 70669996
Haemoptysis 55.18 11.55 19 147478 51433 70729514
Treatment noncompliance 54.96 11.55 217 147280 46357 70734590
Speech disorder 53.63 11.55 228 147269 50352 70730595
Learning disorder 53.04 11.55 25 147472 530 70780417
Speech disorder developmental 52.88 11.55 26 147471 607 70780340
Epidermal necrosis 51.93 11.55 34 147463 1391 70779556
Wheezing 51.84 11.55 72 147425 94098 70686849
Impulsive behaviour 51.45 11.55 44 147453 2710 70778237
Loss of consciousness 51.20 11.55 522 146975 155194 70625753
Anticonvulsant drug level below therapeutic 51.09 11.55 30 147467 1009 70779938
Diverticulitis 51.06 11.55 12 147485 41722 70739225
Temporal lobe epilepsy 50.73 11.55 22 147475 381 70780566
Distributive shock 50.72 11.55 40 147457 2197 70778750
Blood prolactin increased 50.67 11.55 50 147447 3704 70777243
Unintended pregnancy 50.63 11.55 47 147450 3226 70777721
Therapeutic response unexpected 50.54 11.55 115 147382 18116 70762831
Asthma 50.43 11.55 110 147387 120683 70660264
Osteoarthritis 50.21 11.55 48 147449 74099 70706848
Skin degenerative disorder 50.04 11.55 12 147485 21 70780926
Hallucination, visual 49.64 11.55 154 147343 29183 70751764
Hallucination 49.26 11.55 299 147198 75961 70704986
Tonic convulsion 49.20 11.55 38 147459 2024 70778923
Euphoric mood 49.16 11.55 66 147431 6823 70774124
Cataplexy 49.00 11.55 29 147468 990 70779957
Malaise 48.93 11.55 621 146876 432311 70348636
Dysmetria 48.77 11.55 28 147469 902 70780045
Psychomotor skills impaired 48.65 11.55 52 147445 4232 70776715
Abulia 48.63 11.55 28 147469 907 70780040
Drug screen false positive 48.63 11.55 29 147468 1004 70779943
Platelet count decreased 48.59 11.55 198 147299 178024 70602923
Decreased appetite 48.50 11.55 403 147094 304377 70476570
Pulmonary embolism 48.49 11.55 164 147333 155703 70625244
Accidental overdose 48.40 11.55 172 147325 34949 70745998
Transaminases increased 48.35 11.55 210 147287 46808 70734139
Neoplasm progression 47.99 11.55 17 147480 45211 70735736
Abdominal pain upper 47.97 11.55 223 147274 193379 70587568
Drug withdrawal convulsions 47.83 11.55 38 147459 2110 70778837
Pulmonary arterial hypertension 47.74 11.55 6 147491 32849 70748098
Staring 47.44 11.55 40 147457 2416 70778531
Enanthema 47.36 11.55 26 147471 767 70780180
Chest discomfort 47.33 11.55 119 147378 124262 70656685
Eosinophilic myocarditis 47.02 11.55 27 147470 870 70780077
Angina pectoris 46.73 11.55 21 147476 48362 70732585
Lip ulceration 46.62 11.55 37 147460 2051 70778896
Ischaemic stroke 46.35 11.55 5 147492 30815 70750132
Melaena 46.34 11.55 30 147467 56325 70724622
Hypersensitivity 46.23 11.55 284 147213 229528 70551419
Constipation 46.20 11.55 321 147176 252117 70528830
Confusional state 46.02 11.55 839 146658 283559 70497388
Disorientation 45.95 11.55 240 147257 57683 70723264
Pregnancy with implant contraceptive 45.88 11.55 33 147464 1576 70779371
Heart rate decreased 45.79 11.55 37 147460 61978 70718969
Hypomagnesaemia 45.57 11.55 14 147483 40750 70740197
Mouth ulceration 45.44 11.55 166 147331 34183 70746764
Upper gastrointestinal haemorrhage 45.41 11.55 11 147486 37466 70743481
Skin exfoliation 45.36 11.55 211 147286 48415 70732532
Change in seizure presentation 45.07 11.55 19 147478 306 70780641
Postictal state 44.99 11.55 33 147464 1625 70779322
Nausea 44.99 11.55 1390 146107 850698 69930249
Illusion 44.97 11.55 33 147464 1626 70779321
Cellulitis 44.76 11.55 86 147411 98842 70682105
Cerebral infarction 44.23 11.55 17 147480 42992 70737955
Lactic acidosis 44.14 11.55 42 147455 64982 70715965
Blood creatine phosphokinase increased 43.98 11.55 247 147250 61016 70719931
Abdominal distension 43.95 11.55 95 147402 104574 70676373
Mucosal inflammation 43.57 11.55 46 147451 67804 70713143
Withdrawal syndrome 43.31 11.55 132 147365 24772 70756175
Pulmonary oedema 43.23 11.55 65 147432 82213 70698734
Inappropriate affect 43.01 11.55 30 147467 1364 70779583
Product dispensing error 42.88 11.55 84 147413 11924 70769023
Live birth 42.82 11.55 91 147406 13688 70767259
Therapeutic response changed 42.64 11.55 27 147470 1042 70779905
Irregular sleep phase 42.61 11.55 13 147484 75 70780872
Increased appetite 42.56 11.55 78 147419 10535 70770412
Osteonecrosis of jaw 42.51 11.55 16 147481 40986 70739961
Colitis 42.41 11.55 42 147455 63772 70717175
Vision blurred 42.24 11.55 340 147157 94644 70686303
Suicide threat 42.15 11.55 12 147485 52 70780895
Salivary hypersecretion 42.08 11.55 87 147410 12838 70768109
Excessive eye blinking 42.00 11.55 30 147467 1417 70779530
Injection site erythema 41.92 11.55 54 147443 72870 70708077
Mental status changes 41.77 11.55 249 147248 62852 70718095
Wrong patient received product 41.67 11.55 49 147448 4431 70776516
Oculomucocutaneous syndrome 41.65 11.55 18 147479 309 70780638
Pharyngeal erythema 41.51 11.55 33 147464 1834 70779113
Hypertonia 41.48 11.55 59 147438 6439 70774508
Caesarean section 41.22 11.55 81 147416 11526 70769421
Psychogenic seizure 41.06 11.55 33 147464 1863 70779084
Haematuria 40.93 11.55 43 147454 63530 70717417
Influenza 40.81 11.55 112 147385 113588 70667359
Obsessive thoughts 40.75 11.55 26 147471 1017 70779930
Pain in jaw 40.47 11.55 19 147478 42650 70738297
Migraine 40.35 11.55 273 147224 71965 70708982
Blood creatinine increased 40.16 11.55 157 147340 142844 70638103
Inappropriate antidiuretic hormone secretion 40.14 11.55 123 147374 23153 70757794
Hostility 40.05 11.55 35 147462 2220 70778727
Lung neoplasm malignant 39.93 11.55 3 147494 24739 70756208
Drug abuse 39.85 11.55 475 147022 146781 70634166
Simple partial seizures 39.56 11.55 22 147475 666 70780281
Nasal congestion 39.46 11.55 47 147450 65625 70715322
Metastases to liver 39.43 11.55 4 147493 25874 70755073
Pregnancy on oral contraceptive 39.21 11.55 23 147474 772 70780175
Fibromyalgia 38.67 11.55 26 147471 47848 70733099
Intermenstrual bleeding 38.54 11.55 51 147446 5199 70775748
Distractibility 38.48 11.55 22 147475 703 70780244
Dysmorphism 38.44 11.55 20 147477 528 70780419
Gambling disorder 38.34 11.55 32 147465 1906 70779041
Thrombosis 38.25 11.55 61 147436 75344 70705603
Coma scale abnormal 38.19 11.55 64 147433 8052 70772895
Persecutory delusion 38.08 11.55 47 147450 4470 70776477
Prostate cancer 38.05 11.55 9 147488 31154 70749793
Tachycardia 38.01 11.55 500 146997 158046 70622901
Educational problem 38.00 11.55 18 147479 386 70780561
Gait disturbance 37.64 11.55 567 146930 184539 70596408
Osteoporosis 37.61 11.55 28 147469 48879 70732068
Cytomegalovirus infection 37.25 11.55 18 147479 39740 70741207
Injection site pain 37.09 11.55 123 147374 117496 70663451
Tonic clonic movements 37.08 11.55 32 147465 1995 70778952
Off label use 37.04 11.55 1221 146276 741839 70039108
Wrong schedule 36.97 11.55 17 147480 340 70780607
Intellectual disability 36.87 11.55 25 147472 1085 70779862
Coordination abnormal 36.66 11.55 94 147403 15972 70764975
Dissociation 36.63 11.55 40 147457 3336 70777611
Septic shock 36.37 11.55 116 147381 112142 70668805
Drug titration error 36.29 11.55 24 147473 999 70779948
Pulmonary fibrosis 36.23 11.55 13 147484 34297 70746650
Bursitis 36.13 11.55 6 147491 26667 70754280
Lennox-Gastaut syndrome 36.13 11.55 15 147482 232 70780715
Pneumocystis jirovecii pneumonia 36.12 11.55 9 147488 30073 70750874
Drug clearance increased 36.07 11.55 15 147482 233 70780714
Product use issue 35.84 11.55 223 147274 179714 70601233
Lymphangioleiomyomatosis 35.39 11.55 13 147484 142 70780805
SJS-TEN overlap 35.38 11.55 19 147478 536 70780411
Libido increased 35.20 11.55 30 147467 1839 70779108
Learning disability 35.05 11.55 14 147483 195 70780752
Retinogram abnormal 34.93 11.55 16 147481 317 70780630
Joint range of motion decreased 34.93 11.55 6 147491 26020 70754927
Erythema 34.84 11.55 596 146901 198967 70581980
Oral mucosal blistering 34.81 11.55 50 147447 5506 70775441
Weight decreased 34.80 11.55 446 147051 310042 70470905
Urinary tract infection 34.72 11.55 340 147157 248429 70532518
Cerebellar atrophy 34.59 11.55 24 147473 1082 70779865
Knee arthroplasty 34.55 11.55 14 147483 34287 70746660
Ureteric perforation 34.53 11.55 8 147489 11 70780936
Erythema of eyelid 34.51 11.55 32 147465 2193 70778754
Hip arthroplasty 34.43 11.55 8 147489 28032 70752915
Placental disorder 34.31 11.55 22 147475 868 70780079
Mucosal erosion 34.27 11.55 31 147466 2058 70778889
Skin erosion 34.20 11.55 42 147455 3974 70776973
Aphasia 34.17 11.55 179 147318 43070 70737877
Haemorrhoids 34.12 11.55 6 147491 25582 70755365
Rash vesicular 34.07 11.55 48 147449 5192 70775755
Benzodiazepine drug level increased 34.05 11.55 14 147483 211 70780736
Traumatic coma 33.96 11.55 10 147487 50 70780897
Affect lability 33.86 11.55 69 147428 10077 70770870
Human herpesvirus 6 infection 33.83 11.55 46 147451 4813 70776134
Derealisation 33.83 11.55 27 147470 1509 70779438
COVID-19 33.76 11.55 110 147387 105647 70675300
Drug resistance 33.64 11.55 163 147334 38027 70742920
Cytokine release syndrome 33.61 11.55 7 147490 26460 70754487
Rapid eye movement sleep behaviour disorder 33.53 11.55 16 147481 349 70780598
Cerebral atrophy 33.52 11.55 58 147439 7489 70773458
Photophobia 33.51 11.55 100 147397 18550 70762397
Epistaxis 33.28 11.55 106 147391 102521 70678426
Angiofibroma 33.26 11.55 12 147485 124 70780823
Cataract 33.24 11.55 40 147457 55605 70725342
Bone pain 33.14 11.55 34 147463 50788 70730159
Psoriasis 33.10 11.55 100 147397 98333 70682614
Product administration error 32.79 11.55 135 147362 29388 70751559
Seizure cluster 32.68 11.55 16 147481 370 70780577
Stomatitis 32.43 11.55 147 147350 128364 70652583
Persistent genital arousal disorder 32.35 11.55 15 147482 306 70780641
Negative symptoms in schizophrenia 32.27 11.55 12 147485 136 70780811
Multiple congenital abnormalities 32.13 11.55 11 147486 96 70780851
Paradoxical drug reaction 32.12 11.55 53 147444 6583 70774364
Psychiatric symptom 32.08 11.55 53 147444 6591 70774356
Hepatocellular injury 31.88 11.55 184 147313 45907 70735040
Granulocytopenia 31.58 11.55 69 147428 10578 70770369
Femur fracture 31.43 11.55 18 147479 36114 70744833
Oxygen saturation decreased 31.31 11.55 130 147367 116299 70664648
Posture abnormal 31.26 11.55 38 147459 3558 70777389
Peritonitis 31.07 11.55 8 147489 26151 70754796
Palmar-plantar erythrodysaesthesia syndrome 31.03 11.55 12 147485 30235 70750712
Chapped lips 30.96 11.55 30 147467 2173 70778774
Oedema 30.85 11.55 111 147386 103470 70677477
Autism spectrum disorder 30.63 11.55 22 147475 1048 70779899
Treatment failure 30.62 11.55 175 147322 143967 70636980
Personality disorder 30.56 11.55 47 147450 5501 70775446
Gestational diabetes 30.50 11.55 49 147448 5952 70774995
Flat affect 30.49 11.55 28 147469 1895 70779052
Delirium 30.46 11.55 262 147235 74352 70706595
Gastric ulcer 30.39 11.55 14 147483 31776 70749171
Blood cholesterol increased 30.25 11.55 55 147442 64549 70716398
Hepatic cirrhosis 30.21 11.55 13 147484 30718 70750229
Psychotic symptom 30.20 11.55 31 147466 2407 70778540
Hypoxia 29.85 11.55 97 147400 93247 70687700
Device related infection 29.51 11.55 15 147482 32170 70748777
Genital erosion 29.47 11.55 15 147482 378 70780569
Gout 29.39 11.55 6 147491 23000 70757947
Red blood cell sedimentation rate abnormal 29.36 11.55 3 147494 19300 70761647
Symblepharon 29.24 11.55 12 147485 180 70780767
Hepatotoxicity 29.17 11.55 29 147468 43957 70736990
Basal cell carcinoma 29.01 11.55 17 147480 33681 70747266
Cystitis 28.84 11.55 33 147464 46908 70734039
Feelings of worthlessness 28.75 11.55 16 147481 485 70780462
Neoplasm malignant 28.56 11.55 12 147485 28762 70752185
Hypokalaemia 28.56 11.55 158 147339 131030 70649917
Blood pressure diastolic decreased 28.56 11.55 9 147488 25771 70755176
Suspiciousness 28.19 11.55 17 147480 601 70780346
Right ventricular failure 28.06 11.55 6 147491 22268 70758679
Lethargy 28.02 11.55 259 147238 74991 70705956
Syncope 27.76 11.55 216 147281 165493 70615454
Hypotension 27.71 11.55 635 146862 403746 70377201
Cerebellar ataxia 27.60 11.55 26 147471 1818 70779129
Dysphoria 27.48 11.55 40 147457 4458 70776489
Scab 27.46 11.55 61 147436 9457 70771490
Injury corneal 27.42 11.55 9 147488 68 70780879
Skin ulcer 27.31 11.55 36 147461 48109 70732838
Bundle branch block right 27.30 11.55 65 147432 10545 70770402
Full blood count decreased 27.13 11.55 8 147489 23910 70757037
Drooling 27.10 11.55 44 147453 5392 70775555
Feeling drunk 26.92 11.55 39 147458 4328 70776619
Pneumonitis 26.91 11.55 45 147452 54552 70726395
Hyperglycaemia 26.89 11.55 59 147438 64613 70716334
Hypoglycaemia 26.87 11.55 103 147394 94261 70686686
Chronic kidney disease 26.82 11.55 54 147443 61003 70719944
Oesophagitis 26.77 11.55 7 147490 22645 70758302
Automatism 26.74 11.55 11 147486 166 70780781
Oral mucosal eruption 26.69 11.55 17 147480 663 70780284
Hyperprolactinaemia 26.61 11.55 39 147458 4374 70776573
Product quality issue 26.61 11.55 130 147367 30431 70750516
Injection site bruising 26.48 11.55 24 147473 38008 70742939
Self-medication 26.41 11.55 39 147458 4404 70776543
Microcephaly 26.27 11.55 11 147486 174 70780773
Myelosuppression 26.24 11.55 15 147482 30130 70750817
Premature labour 26.22 11.55 54 147443 7946 70773001
Bezoar 26.21 11.55 28 147469 2278 70778669
Haemorrhage 26.18 11.55 88 147409 83727 70697220
Premature baby 26.16 11.55 34 147463 3405 70777542
Decreased interest 26.15 11.55 34 147463 3407 70777540
Transferrin increased 26.11 11.55 7 147490 23 70780924
Neonatal infection 26.11 11.55 7 147490 23 70780924
Transfusion 26.05 11.55 4 147493 18832 70762115
Hypercalcaemia 26.03 11.55 20 147477 34365 70746582
Blood glucose increased 25.86 11.55 118 147379 102864 70678083
Adrenal insufficiency 25.84 11.55 10 147487 25185 70755762
Intention tremor 25.72 11.55 17 147480 707 70780240
Tongue biting 25.65 11.55 25 147472 1824 70779123
Hypotonia 25.62 11.55 68 147429 11797 70769150
Pulmonary mass 25.61 11.55 11 147486 26022 70754925
Skin lesion 25.60 11.55 152 147345 38308 70742639
Purpura 25.60 11.55 89 147408 17886 70763061
Localised infection 25.47 11.55 19 147478 33139 70747808
Colitis ulcerative 25.34 11.55 20 147477 33903 70747044
Parasomnia 25.29 11.55 15 147482 514 70780433
Nightmare 25.15 11.55 102 147395 22054 70758893
Cerebral haemorrhage 25.09 11.55 46 147451 53818 70727129
Pregnancy 25.05 11.55 107 147390 23674 70757273
Delusional perception 25.03 11.55 13 147484 342 70780605
Postictal paralysis 24.96 11.55 13 147484 344 70780603
Cardiac disorder 24.88 11.55 54 147443 59361 70721586
Urinary incontinence 24.83 11.55 149 147348 37693 70743254
False positive investigation result 24.65 11.55 18 147479 880 70780067
Angiomyolipoma 24.63 11.55 11 147486 205 70780742
Tachyphrenia 24.52 11.55 25 147472 1926 70779021
Persistent depressive disorder 24.44 11.55 19 147478 1022 70779925
Hepatosplenomegaly 24.43 11.55 43 147454 5627 70775320
Hypervolaemia 24.30 11.55 28 147469 39678 70741269
Drug level changed 24.28 11.55 15 147482 554 70780393
Convulsive threshold lowered 24.19 11.55 18 147479 906 70780041
Pseudolymphoma 24.18 11.55 19 147478 1038 70779909
Clostridium difficile infection 24.16 11.55 27 147470 38789 70742158
Musculoskeletal stiffness 24.10 11.55 194 147303 147566 70633381
Sternal fracture 24.03 11.55 27 147470 2324 70778623
Metastases to lung 23.97 11.55 3 147494 16481 70764466
Red blood cell sedimentation rate increased 23.92 11.55 27 147470 38615 70742332
Hypersomnia 23.89 11.55 96 147401 20668 70760279
Therapeutic product effective for unapproved indication 23.89 11.55 9 147488 106 70780841
Hyperexplexia 23.78 11.55 7 147490 35 70780912
Osteomyelitis 23.77 11.55 17 147480 30301 70750646
Delivery 23.71 11.55 15 147482 578 70780369
Blister 23.65 11.55 316 147181 100210 70680737
Eyelid oedema 23.59 11.55 69 147428 12658 70768289
Hospitalisation 23.59 11.55 90 147407 82478 70698469
Galactorrhoea 23.55 11.55 32 147465 3346 70777601
Developmental delay 23.54 11.55 19 147478 1079 70779868
Dermatitis bullous 23.49 11.55 69 147428 12688 70768259
Apnoea 23.39 11.55 62 147435 10747 70770200
Soft tissue injury 23.36 11.55 23 147474 1699 70779248
Amnesia 23.35 11.55 187 147310 51968 70728979
Sinus congestion 23.33 11.55 4 147493 17369 70763578
Altered pitch perception 23.30 11.55 6 147491 16 70780931
Hyperammonaemia 23.25 11.55 60 147437 10233 70770714
Anaphylactic shock 23.22 11.55 20 147477 32470 70748477
Disseminated intravascular coagulation 23.15 11.55 134 147363 33464 70747483
Developmental regression 23.15 11.55 7 147490 39 70780908
Clostridium difficile colitis 23.08 11.55 16 147481 28980 70751967
Heart rate irregular 22.90 11.55 17 147480 29726 70751221
Pulmonary congestion 22.65 11.55 12 147485 25142 70755805
Drug dose titration not performed 22.64 11.55 16 147481 743 70780204
Atrial septal defect 22.58 11.55 23 147474 1770 70779177
Histiocytosis 22.57 11.55 7 147490 43 70780904
Haematemesis 22.44 11.55 42 147455 48755 70732192
Hiatus hernia 22.32 11.55 8 147489 21126 70759821
Dermatitis exfoliative 22.31 11.55 60 147437 10491 70770456
Acute coronary syndrome 22.26 11.55 7 147490 20072 70760875
Bacteraemia 22.25 11.55 17 147480 29292 70751655
Snoring 22.19 11.55 38 147459 4866 70776081
Retinal deposits 22.17 11.55 9 147488 131 70780816
Blood pressure diastolic abnormal 22.12 11.55 3 147494 15501 70765446
Bronchopulmonary aspergillosis 22.10 11.55 8 147489 20994 70759953
Brain death 21.96 11.55 39 147458 5139 70775808
Bacterial infection 21.92 11.55 14 147483 26478 70754469
Macule 21.81 11.55 27 147470 2576 70778371
Cardiovascular symptom 21.79 11.55 7 147490 49 70780898
Hepatic enzyme increased 21.71 11.55 215 147282 156775 70624172
Differential white blood cell count abnormal 21.59 11.55 23 147474 1865 70779082
Tongue eruption 21.57 11.55 8 147489 90 70780857
Lip scab 21.53 11.55 5 147492 7 70780940
Plagiocephaly 21.46 11.55 6 147491 24 70780923
Lymphadenitis 21.45 11.55 34 147463 4083 70776864
Pregnancy with contraceptive device 21.44 11.55 30 147467 3225 70777722
Brain malformation 21.43 11.55 7 147490 52 70780895
Nephropathy toxic 21.35 11.55 6 147491 18508 70762439
Impatience 21.31 11.55 14 147483 576 70780371
Sleep-related eating disorder 21.27 11.55 15 147482 694 70780253
Cholestasis of pregnancy 21.27 11.55 17 147480 952 70779995
Normal newborn 21.21 11.55 43 147454 6257 70774690
Idiopathic generalised epilepsy 21.20 11.55 7 147490 54 70780893
Hypothermia 21.18 11.55 92 147405 20502 70760445
Resting tremor 21.14 11.55 20 147477 1406 70779541
Ventricular septal defect 21.10 11.55 13 147484 478 70780469
Bladder cancer 21.01 11.55 5 147492 17237 70763710
Mitral valve incompetence 20.94 11.55 15 147482 26713 70754234
Contusion 20.93 11.55 168 147329 127868 70653079
Essential tremor 20.89 11.55 20 147477 1427 70779520
Sleep paralysis 20.87 11.55 14 147483 597 70780350
Nephrogenic diabetes insipidus 20.85 11.55 23 147474 1940 70779007
Lymphocytic infiltration 20.83 11.55 20 147477 1432 70779515
Post-traumatic neck syndrome 20.75 11.55 23 147474 1950 70778997
Epidermolysis 20.74 11.55 13 147484 493 70780454
Electrocardiogram ST segment depression 20.58 11.55 35 147462 4456 70776491
Lymphocyte morphology abnormal 20.57 11.55 16 147481 861 70780086
Pregnancy on contraceptive 20.57 11.55 16 147481 861 70780086
Vomiting projectile 20.56 11.55 21 147476 1621 70779326
Blood potassium increased 20.55 11.55 16 147481 27310 70753637
Eye discharge 20.55 11.55 39 147458 5408 70775539
Hereditary ataxia 20.55 11.55 6 147491 29 70780918
Maternal drugs affecting foetus 20.54 11.55 21 147476 1623 70779324
Conjunctival abrasion 20.42 11.55 5 147492 10 70780937
Attention deficit hyperactivity disorder 20.38 11.55 28 147469 2959 70777988
Terminal insomnia 20.36 11.55 17 147480 1013 70779934
Vulvar erosion 20.34 11.55 9 147488 164 70780783
Somnambulism 20.26 11.55 38 147459 5222 70775725
Miosis 20.24 11.55 70 147427 14031 70766916
Tonsillar hypertrophy 20.03 11.55 19 147478 1340 70779607
White blood cell count decreased 19.94 11.55 242 147255 169899 70611048
Visual field defect 19.91 11.55 50 147447 8388 70772559
Lip oedema 19.87 11.55 39 147458 5544 70775403
Colon cancer 19.87 11.55 3 147494 14303 70766644
Viral rash 19.72 11.55 11 147486 335 70780612
Self esteem decreased 19.70 11.55 16 147481 917 70780030
Wound infection 19.65 11.55 6 147491 17536 70763411
Concussion 19.64 11.55 50 147447 8459 70772488
Homicidal ideation 19.51 11.55 29 147468 3294 70777653
Judgement impaired 19.33 11.55 17 147480 1087 70779860
Fungal infection 19.29 11.55 30 147467 37437 70743510
Inflammation 19.23 11.55 91 147406 78574 70702373
Exomphalos 19.17 11.55 7 147490 75 70780872
Respiratory depression 19.08 11.55 102 147395 24729 70756218
Regressive behaviour 19.08 11.55 8 147489 127 70780820
COVID-19 pneumonia 19.03 11.55 11 147486 21958 70758989
Bronchiectasis 18.97 11.55 5 147492 16092 70764855
Mucosal ulceration 18.95 11.55 21 147476 1780 70779167
Shock haemorrhagic 18.88 11.55 7 147490 18099 70762848
Bipolar II disorder 18.81 11.55 11 147486 367 70780580
Echolalia 18.76 11.55 11 147486 369 70780578
Lipids 18.75 11.55 5 147492 16 70780931
Haematotoxicity 18.69 11.55 3 147494 13671 70767276
Economic problem 18.69 11.55 23 147474 2181 70778766
Torticollis 18.64 11.55 23 147474 2186 70778761
Bone marrow failure 18.55 11.55 47 147450 48963 70731984
Ejection fraction decreased 18.49 11.55 22 147475 30740 70750207
Lower gastrointestinal haemorrhage 18.47 11.55 4 147493 14716 70766231
Retinal pigmentation 18.39 11.55 7 147490 85 70780862
Tricuspid valve incompetence 18.39 11.55 7 147490 17810 70763137
Joint stiffness 18.27 11.55 28 147469 35148 70745799
Drop attacks 18.24 11.55 16 147481 1020 70779927
Flight of ideas 18.19 11.55 14 147483 742 70780205
Wrong product administered 18.17 11.55 48 147449 8303 70772644
Vanishing bile duct syndrome 18.15 11.55 18 147479 1341 70779606
Gamma-glutamyltransferase increased 18.14 11.55 173 147324 50512 70730435
Congenital anomaly 18.12 11.55 10 147487 298 70780649
Stereotypy 18.12 11.55 15 147482 883 70780064
Ocular hyperaemia 18.12 11.55 100 147397 24539 70756408
Myalgia 18.11 11.55 243 147254 167649 70613298
Anticonvulsant drug level therapeutic 18.09 11.55 5 147492 19 70780928
Conjunctival erosion 18.07 11.55 8 147489 146 70780801
Central nervous system lesion 18.03 11.55 62 147435 12391 70768556
Blood calcium decreased 18.02 11.55 20 147477 28826 70752121
Conjunctival disorder 17.97 11.55 10 147487 303 70780644
Dyslexia 17.97 11.55 9 147488 219 70780728
Respiratory failure 17.92 11.55 245 147252 168490 70612457
Tendonitis 17.88 11.55 12 147485 22110 70758837
Hepatic encephalopathy 17.88 11.55 12 147485 22106 70758841
Cardiac failure acute 17.83 11.55 7 147490 17480 70763467
Placental infarction 17.82 11.55 8 147489 151 70780796
Gastric disorder 17.81 11.55 26 147471 33296 70747651
Sciatica 17.80 11.55 15 147482 24612 70756335
Burnout syndrome 17.79 11.55 10 147487 309 70780638
Movement disorder 17.79 11.55 98 147399 24031 70756916
Palpitations 17.79 11.55 146 147351 110607 70670340
Panic attack 17.78 11.55 92 147405 22027 70758920
Frequent bowel movements 17.75 11.55 11 147486 21142 70759805
Chills 17.71 11.55 204 147293 144582 70636365
Limbic encephalitis 17.70 11.55 14 147483 772 70780175
Compulsive shopping 17.67 11.55 14 147483 774 70780173
Spinal osteoarthritis 17.65 11.55 5 147492 15343 70765604
Therapy non-responder 17.64 11.55 91 147406 76824 70704123
Leukocytosis 17.63 11.55 142 147355 39526 70741421
Anorgasmia 17.60 11.55 16 147481 1069 70779878
Gastric haemorrhage 17.51 11.55 4 147493 14181 70766766
Drug screen positive 17.49 11.55 38 147459 5802 70775145
Gastritis 17.47 11.55 42 147455 44549 70736398
Coprolalia 17.46 11.55 6 147491 53 70780894
Bile acid malabsorption 17.46 11.55 9 147488 233 70780714
Hyperhomocysteinaemia 17.43 11.55 11 147486 422 70780525
Respiratory acidosis 17.42 11.55 54 147443 10227 70770720
Presyncope 17.41 11.55 32 147465 37406 70743541
Strabismus 17.41 11.55 23 147474 2341 70778606
Blood urea increased 17.40 11.55 44 147453 45865 70735082
Rash pruritic 17.38 11.55 204 147293 62787 70718160
Pyramidal tract syndrome 17.35 11.55 12 147485 538 70780409
Lymphocyte stimulation test positive 17.32 11.55 16 147481 1091 70779856
Schizophrenia 17.32 11.55 75 147422 16693 70764254
Drug withdrawal syndrome 17.30 11.55 122 147375 32593 70748354
Nodule 17.29 11.55 10 147487 19959 70760988
Haematocrit decreased 17.28 11.55 61 147436 57197 70723750
Autoscopy 17.27 11.55 6 147491 55 70780892
Acute psychosis 17.27 11.55 30 147467 3886 70777061
Restless legs syndrome 17.21 11.55 80 147417 18348 70762599
Myelodysplastic syndrome 17.17 11.55 22 147475 29763 70751184
Coma scale 17.17 11.55 6 147491 56 70780891
International normalised ratio increased 17.14 11.55 98 147399 80628 70700319
Cleft lip 17.06 11.55 4 147493 6 70780941
Stupor 16.88 11.55 40 147457 6469 70774478
Type IV hypersensitivity reaction 16.80 11.55 28 147469 3507 70777440
Transient ischaemic attack 16.67 11.55 45 147452 45899 70735048
Gait deviation 16.63 11.55 6 147491 62 70780885
Intentional product misuse 16.62 11.55 245 147252 79350 70701597
Head titubation 16.60 11.55 14 147483 846 70780101
Brain oedema 16.53 11.55 94 147403 23324 70757623
Maternal exposure before pregnancy 16.52 11.55 29 147468 3787 70777160
Loss of personal independence in daily activities 16.50 11.55 106 147391 84804 70696143
Spinal stenosis 16.44 11.55 5 147492 14648 70766299
Oscillopsia 16.42 11.55 8 147489 183 70780764
Hallucinations, mixed 16.39 11.55 39 147458 6323 70774624
Herpangina 16.36 11.55 5 147492 29 70780918
Immunodeficiency 16.36 11.55 8 147489 17547 70763400
Squamous cell carcinoma 16.35 11.55 5 147492 14599 70766348
Disinhibition 16.35 11.55 22 147475 2279 70778668
Inappropriate schedule of product administration 16.28 11.55 144 147353 107411 70673536
Incorrect dose administered 16.22 11.55 211 147286 66508 70714439
Sleep disorder 16.17 11.55 219 147278 69653 70711294
Injection site pruritus 16.11 11.55 36 147461 39174 70741773
Neurosurgery 16.08 11.55 5 147492 31 70780916
Premature rupture of membranes 16.07 11.55 29 147468 3869 70777078
Dysphonia 16.06 11.55 52 147445 50048 70730899
Unevaluable event 16.03 11.55 55 147442 52008 70728939
Congenital renal disorder 16.02 11.55 4 147493 9 70780938
Selective IgA immunodeficiency 16.02 11.55 4 147493 9 70780938
Vulval disorder 15.99 11.55 11 147486 489 70780458
Hyperphagia 15.92 11.55 22 147475 2337 70778610
Alopecia universalis 15.92 11.55 8 147489 196 70780751
Musculoskeletal disorder 15.92 11.55 11 147486 19960 70760987
Emotional disorder 15.90 11.55 62 147435 13164 70767783
Muscle spasms 15.88 11.55 225 147272 153821 70627126
Pancytopenia 15.83 11.55 220 147277 150887 70630060
Peripheral sensory neuropathy 15.80 11.55 3 147494 12107 70768840
Large intestine perforation 15.74 11.55 4 147493 13191 70767756
Flatulence 15.74 11.55 35 147462 38146 70742801
Throat irritation 15.70 11.55 31 147466 35273 70745674
Renal tubular necrosis 15.68 11.55 15 147482 23156 70757791
Illogical thinking 15.68 11.55 6 147491 74 70780873
Injection site haemorrhage 15.62 11.55 18 147479 25509 70755438
Gestational hypertension 15.61 11.55 19 147478 1781 70779166
Hyperkinesia 15.55 11.55 23 147474 2600 70778347
Laryngeal tremor 15.53 11.55 3 147494 0 70780947
Congenital cardiovascular anomaly 15.53 11.55 3 147494 0 70780947
Neonatal aspiration 15.53 11.55 3 147494 0 70780947
Angular cheilitis 15.51 11.55 12 147485 641 70780306
Oral mucosal erythema 15.47 11.55 19 147478 1798 70779149
Blood pressure decreased 15.45 11.55 119 147378 91396 70689551
Aspergillus infection 15.40 11.55 9 147488 17859 70763088
Morose 15.32 11.55 5 147492 37 70780910
Musculoskeletal chest pain 15.27 11.55 15 147482 22866 70758081
Blood pressure systolic abnormal 15.23 11.55 4 147493 12905 70768042
Pancreatic carcinoma 15.22 11.55 4 147493 12900 70768047
Encephalocele 15.21 11.55 5 147492 38 70780909
Pectus excavatum 15.19 11.55 4 147493 12 70780935
Tooth malformation 15.12 11.55 6 147491 82 70780865
Injection site swelling 15.12 11.55 43 147454 43114 70737833
Opsoclonus myoclonus 15.11 11.55 8 147489 219 70780728
Blood magnesium decreased 15.04 11.55 6 147491 14835 70766112
Orthostatic hypotension 15.04 11.55 56 147441 51687 70729260
Dyspepsia 14.96 11.55 116 147381 88961 70691986
Wrong patient 14.95 11.55 9 147488 317 70780630
Diabetes mellitus inadequate control 14.93 11.55 15 147482 22630 70758317
Heavy menstrual bleeding 14.93 11.55 59 147438 12606 70768341
Dysmetropsia 14.93 11.55 6 147491 85 70780862
Squamous cell carcinoma of skin 14.88 11.55 4 147493 12708 70768239
Grip strength decreased 14.85 11.55 7 147490 15678 70765269
Bone disorder 14.80 11.55 9 147488 17481 70763466
Epidermolysis bullosa 14.79 11.55 8 147489 229 70780718
Skin disorder 14.78 11.55 111 147386 30246 70750701
Diverticulum 14.78 11.55 5 147492 13688 70767259
Accidental death 14.77 11.55 28 147469 3880 70777067
Borderline personality disorder 14.76 11.55 13 147484 833 70780114
Vestibular migraine 14.70 11.55 7 147490 152 70780795
Large intestine polyp 14.65 11.55 3 147494 11473 70769474
Spinal compression fracture 14.63 11.55 7 147490 15546 70765401
Pigmentation disorder 14.52 11.55 32 147465 4934 70776013
Skin cancer 14.51 11.55 5 147492 13531 70767416
Bruxism 14.44 11.55 27 147470 3702 70777245
Rhinorrhoea 14.40 11.55 80 147417 66291 70714656
Dysphemia 14.39 11.55 25 147472 3238 70777709
Blood loss anaemia 14.37 11.55 6 147491 14435 70766512
Anaphylactic reaction 14.36 11.55 94 147403 74880 70706067
Creatinine renal clearance decreased 14.35 11.55 9 147488 17191 70763756
Thrombocytopenia 14.31 11.55 383 147114 238727 70542220
Acute myopia 14.27 11.55 6 147491 96 70780851
Insomnia 14.25 11.55 571 146926 217235 70563712
Hallucination, olfactory 14.21 11.55 10 147487 461 70780486
Coronary artery occlusion 14.21 11.55 6 147491 14339 70766608
Hip fracture 14.20 11.55 23 147474 28240 70752707
Antipsychotic drug level above therapeutic 14.18 11.55 19 147478 1960 70778987
Odynophagia 14.16 11.55 50 147447 10125 70770822
Agranulocytosis 14.15 11.55 137 147360 40161 70740786
Neuropsychiatric symptoms 14.13 11.55 14 147483 1042 70779905
Spina bifida 14.10 11.55 6 147491 99 70780848
Limited symptom panic attack 14.09 11.55 5 147492 49 70780898
Renal injury 14.02 11.55 8 147489 16086 70764861
Drug ineffective for unapproved indication 14.02 11.55 132 147365 38406 70742541
Pneumothorax 13.98 11.55 20 147477 25826 70755121
Cholelithiasis 13.91 11.55 51 147446 47289 70733658
Middle insomnia 13.86 11.55 62 147435 13991 70766956
Metastases to central nervous system 13.79 11.55 7 147490 15027 70765920
Lymph node pain 13.78 11.55 16 147481 1427 70779520
Antidepressant drug level above therapeutic 13.76 11.55 11 147486 616 70780331
Hyperuricaemia 13.72 11.55 3 147494 10963 70769984
Conjunctival scar 13.69 11.55 7 147490 178 70780769
Myocarditis 13.63 11.55 76 147421 18717 70762230
Breast cancer 13.63 11.55 31 147466 33518 70747429
Social avoidant behaviour 13.61 11.55 30 147467 4626 70776321
Heart rate increased 13.59 11.55 148 147349 106000 70674947
Conjunctival oedema 13.59 11.55 14 147483 1092 70779855
Exposure via transplant 13.59 11.55 4 147493 20 70780927
Immunodeficiency common variable 13.55 11.55 8 147489 272 70780675
Tongue movement disturbance 13.54 11.55 9 147488 378 70780569
Attention-seeking behaviour 13.52 11.55 6 147491 110 70780837
Screaming 13.49 11.55 26 147471 3646 70777301
Drug withdrawal syndrome neonatal 13.49 11.55 8 147489 274 70780673
Tooth disorder 13.47 11.55 18 147479 23920 70757027
Pharyngeal exudate 13.46 11.55 3 147494 3 70780944
Manic symptom 13.46 11.55 3 147494 3 70780944
Foetal exposure timing unspecified 13.46 11.55 3 147494 3 70780944
Pulmonary toxicity 13.42 11.55 3 147494 10795 70770152
Lymphocyte count decreased 13.40 11.55 46 147451 43493 70737454
Hyperventilation 13.36 11.55 39 147458 7147 70773800
Eclampsia 13.35 11.55 7 147490 188 70780759
Foot deformity 13.26 11.55 14 147483 20641 70760306
Photosensitivity reaction 13.23 11.55 77 147420 19263 70761684
Polyhydramnios 13.23 11.55 16 147481 1490 70779457
Hallucination, tactile 13.17 11.55 10 147487 519 70780428
Protrusion tongue 13.16 11.55 9 147488 396 70780551
Epstein-Barr virus infection reactivation 13.14 11.55 16 147481 1500 70779447
Acquired immunodeficiency syndrome 13.13 11.55 8 147489 288 70780659
Injection site rash 13.13 11.55 9 147488 16401 70764546
Enterococcal infection 13.06 11.55 7 147490 14575 70766372
Joint effusion 13.05 11.55 8 147489 15469 70765478
Verbigeration 12.98 11.55 4 147493 24 70780923
Head injury 12.95 11.55 118 147379 34023 70746924
Hot flush 12.93 11.55 56 147441 49528 70731419
Respiratory tract infection 12.91 11.55 45 147452 42353 70738594
Lip disorder 12.86 11.55 15 147482 1344 70779603
Conversion disorder 12.86 11.55 17 147480 1731 70779216
Lip haemorrhage 12.84 11.55 14 147483 1165 70779782
Sleep disorder due to a general medical condition 12.84 11.55 3 147494 10473 70770474
Carpal tunnel syndrome 12.81 11.55 10 147487 17047 70763900
Oral herpes 12.80 11.55 19 147478 24167 70756780
Physical assault 12.74 11.55 16 147481 1548 70779399
Maternal exposure during pregnancy 12.71 11.55 322 147175 115023 70665924
Conjunctival irritation 12.61 11.55 6 147491 130 70780817
Feeling of despair 12.60 11.55 21 147476 2630 70778317
Acute respiratory failure 12.58 11.55 63 147434 53602 70727345
Intestinal perforation 12.57 11.55 9 147488 16035 70764912
Gastroenteritis 12.55 11.55 29 147468 31184 70749763
Dyscalculia 12.43 11.55 5 147492 71 70780876
Lipids abnormal 12.42 11.55 10 147487 566 70780381
Therapeutic product ineffective for unapproved indication 12.41 11.55 6 147491 135 70780812
Diabetes mellitus 12.31 11.55 93 147404 71731 70709216
Osteochondrosis 12.27 11.55 16 147481 1607 70779340
Congenital renal cyst 12.25 11.55 3 147494 6 70780941
Wound healing normal 12.25 11.55 3 147494 6 70780941
Breast cancer metastatic 12.25 11.55 3 147494 10143 70770804
Illiteracy 12.21 11.55 4 147493 30 70780917
Hypospadias 12.21 11.55 6 147491 140 70780807
Juvenile myoclonic epilepsy 12.18 11.55 5 147492 75 70780872
Gastritis erosive 12.16 11.55 3 147494 10092 70770855
Motor developmental delay 12.15 11.55 7 147490 227 70780720
Subacute cutaneous lupus erythematosus 12.11 11.55 23 147474 3190 70777757
Delusion of grandeur 12.09 11.55 12 147485 895 70780052
Conjunctival ulcer 12.06 11.55 5 147492 77 70780870
Upper respiratory tract infection 12.05 11.55 106 147391 79168 70701779
Post procedural complication 12.03 11.55 17 147480 22064 70758883
Febrile convulsion 12.02 11.55 12 147485 901 70780046
Chorea 12.01 11.55 18 147479 2060 70778887
Paralogism 11.99 11.55 4 147493 32 70780915
Anorexia nervosa 11.96 11.55 7 147490 234 70780713
Medication overuse headache 11.94 11.55 11 147486 748 70780199
Teratogenicity 11.91 11.55 7 147490 236 70780711
Pre-eclampsia 11.87 11.55 35 147462 6450 70774497
Drug-induced liver injury 11.82 11.55 173 147324 55940 70725007
Hyperpyrexia 11.81 11.55 31 147466 5343 70775604
Renal disorder 11.80 11.55 40 147457 37969 70742978
Spinal pain 11.78 11.55 7 147490 13763 70767184
Congestive cardiomyopathy 11.77 11.55 4 147493 10922 70770025
Hypophosphataemia 11.73 11.55 10 147487 16316 70764631
Left ventricular dysfunction 11.72 11.55 12 147485 17945 70763002
Hypersensitivity vasculitis 11.71 11.55 36 147461 6786 70774161
Blood test abnormal 11.68 11.55 8 147489 14582 70766365
Human herpesvirus 6 infection reactivation 11.66 11.55 8 147489 354 70780593
Ideas of reference 11.65 11.55 6 147491 155 70780792
Acquired epidermolysis bullosa 11.61 11.55 5 147492 85 70780862
Failure to thrive 11.61 11.55 4 147493 10825 70770122
Night sweats 11.60 11.55 49 147448 43635 70737312
Renal cancer 11.58 11.55 5 147492 11791 70769156
Rotator cuff syndrome 11.57 11.55 6 147491 12728 70768219

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 35.48 20.06 29 2233 3899 83631
Somnolence 23.96 20.06 37 2225 327 87203
Dehydration 23.31 20.06 41 2221 408 87122
Infantile apnoea 21.08 20.06 42 2220 463 87067

Pharmacologic Action:

SourceCodeDescription
ATC N03AX09 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D011619 Psychotropic Drugs
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:60798 EAA receptor antagonists
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Lennox-Gastaut syndrome indication 230418006
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Pancytopenia contraindication 127034005 DOID:12450
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.3 Basic
pKa2 0.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 4.21 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER IC50 5 CHEMBL CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.77 CHEMBL CHEMBL
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER IC50 4.02 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 3.84 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel IC50 4.74 WOMBAT-PK
Sodium channel protein type X alpha subunit Ion channel IC50 4.60 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel IC50 4.46 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.51 CHEMBL

External reference:

IDSource
D00354 KEGG_DRUG
4020896 VANDF
C0064636 UMLSCUI
CHEBI:6367 CHEBI
CHEMBL741 ChEMBL_ID
DB00555 DRUGBANK_ID
D000077213 MESH_DESCRIPTOR_UI
3878 PUBCHEM_CID
2622 IUPHAR_LIGAND_ID
5638 INN_ID
U3H27498KS UNII
196502 RXNORM
1506 MMSL
4957 MMSL
69610 MMSL
d03809 MMSL
003988 NDDF
387562000 SNOMEDCT_US
96195007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1526 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1527 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1528 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1529 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9939 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9940 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9941 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9942 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections