lamotrigine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1540 84057-84-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lamictal
  • lamotrigine
  • lamitrin
  • lamotrigin
  • BW 430C
A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
  • Molecular weight: 256.09
  • Formula: C9H7Cl2N5
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 90.71
  • ALOGS: -2.72
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.17 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 27.89 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97.60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 27, 1994 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2275.05 10.65 2036 105576 121018 46457432
Drug reaction with eosinophilia and systemic symptoms 1422.45 10.65 872 106740 28676 46549774
Stevens-Johnson syndrome 1112.02 10.65 684 106928 22613 46555837
Epilepsy 1047.37 10.65 663 106949 23075 46555375
Completed suicide 1038.94 10.65 1469 106143 144451 46433999
Exposure during pregnancy 970.49 10.65 1220 106392 106992 46471458
Intentional overdose 875.75 10.65 905 106707 64039 46514411
Toxicity to various agents 758.96 10.65 1571 106041 210195 46368255
Product substitution issue 723.90 10.65 444 107168 14587 46563863
Generalised tonic-clonic seizure 632.36 10.65 514 107098 26608 46551842
Toxic epidermal necrolysis 458.70 10.65 393 107219 21885 46556565
Suicide attempt 437.03 10.65 585 107027 54451 46523999
Drug interaction 419.36 10.65 1220 106392 201874 46376576
Rheumatoid arthritis 417.83 10.65 37 107575 240178 46338272
Intentional self-injury 417.43 10.65 386 107226 23780 46554670
Abortion spontaneous 395.04 10.65 495 107117 43151 46535299
Foetal exposure during pregnancy 344.69 10.65 389 107223 30358 46548092
Diarrhoea 310.45 10.65 509 107103 559093 46019357
Overdose 301.03 10.65 701 106911 101278 46477172
Status epilepticus 298.76 10.65 252 107360 13727 46564723
Suicidal ideation 292.21 10.65 491 107121 55891 46522559
Dyspnoea 278.31 10.65 477 107135 515071 46063379
Rash 264.91 10.65 1561 106051 354951 46223499
Nystagmus 263.26 10.65 164 107448 5535 46572915
Pneumonia 256.87 10.65 294 107318 376026 46202424
Petit mal epilepsy 252.56 10.65 131 107481 3089 46575361
Aggression 248.52 10.65 284 107328 22460 46555990
Drug eruption 246.12 10.65 274 107338 21055 46557395
Lymphadenopathy 240.14 10.65 339 107273 33149 46545301
Agitation 228.69 10.65 437 107175 54978 46523472
Rash maculo-papular 228.35 10.65 301 107311 27573 46550877
Somnolence 227.53 10.65 835 106777 155686 46422764
Mania 226.59 10.65 193 107419 10653 46567797
Ataxia 226.09 10.65 215 107397 13715 46564735
Arthralgia 220.56 10.65 312 107300 364291 46214159
Tremor 217.64 10.65 673 106939 114966 46463484
Pain 215.96 10.65 489 107123 476459 46101991
Focal dyscognitive seizures 207.41 10.65 110 107502 2718 46575732
Oral mucosa erosion 195.95 10.65 79 107533 1011 46577439
Partial seizures 193.93 10.65 129 107483 4881 46573569
Atrial septal defect 186.69 10.65 138 107474 6194 46572256
Joint swelling 179.56 10.65 79 107533 165994 46412456
Diplopia 175.33 10.65 220 107392 19185 46559265
Serotonin syndrome 174.83 10.65 246 107366 23974 46554476
Bipolar disorder 173.48 10.65 139 107473 7038 46571412
Anaemia 171.91 10.65 202 107410 255577 46322873
Selective eating disorder 160.28 10.65 79 107533 1666 46576784
Ventricular septal defect 156.45 10.65 104 107508 3930 46574520
Depression 154.85 10.65 788 106824 169316 46409134
Pain in extremity 154.59 10.65 223 107389 258457 46319993
Peripheral swelling 153.11 10.65 87 107525 157984 46420466
Lip erosion 150.88 10.65 60 107552 739 46577711
Contraindicated product administered 148.25 10.65 9 107603 79938 46498512
Disturbance in attention 146.63 10.65 262 107350 31298 46547152
Irritability 144.48 10.65 248 107364 28698 46549752
Infusion related reaction 144.02 10.65 29 107583 101179 46477271
Sudden unexplained death in epilepsy 141.05 10.65 44 107568 245 46578205
Cough 135.08 10.65 201 107411 230048 46348402
Anticonvulsant drug level decreased 134.54 10.65 63 107549 1181 46577269
Erythema multiforme 133.72 10.65 137 107475 9567 46568883
Nasopharyngitis 131.14 10.65 98 107514 153900 46424550
Abnormal behaviour 130.42 10.65 199 107413 20859 46557591
Conjunctival hyperaemia 128.14 10.65 71 107541 1918 46576532
Abortion induced 127.37 10.65 137 107475 10123 46568327
Pregnancy 126.98 10.65 226 107386 26911 46551539
Maternal exposure during pregnancy 123.57 10.65 516 107096 102033 46476417
Psychotic disorder 122.46 10.65 201 107411 22420 46556030
Aura 121.84 10.65 55 107557 944 46577506
Death 119.87 10.65 386 107226 335162 46243288
Coma 118.50 10.65 349 107263 58000 46520450
Myoclonus 116.00 10.65 154 107458 14198 46564252
Atrial fibrillation 115.56 10.65 47 107565 103543 46474907
Poisoning 114.40 10.65 151 107461 13843 46564607
Myoclonic epilepsy 113.16 10.65 51 107561 872 46577578
Synovitis 112.85 10.65 7 107605 61068 46517382
Hyperreflexia 112.82 10.65 95 107517 5159 46573291
Acute kidney injury 112.00 10.65 235 107377 235620 46342830
Back pain 110.39 10.65 197 107415 209842 46368608
Disease progression 109.27 10.65 37 107575 91263 46487187
Cardiac failure congestive 108.40 10.65 38 107574 91712 46486738
Drug level decreased 107.04 10.65 97 107515 5815 46572635
Arthropathy 105.49 10.65 32 107580 84668 46493782
Clonus 105.00 10.65 82 107530 3998 46574452
Hyperthermia 104.77 10.65 110 107502 7904 46570546
Depressed level of consciousness 103.81 10.65 292 107320 47277 46531173
Electrocardiogram QRS complex prolonged 103.79 10.65 92 107520 5357 46573093
Rash morbilliform 103.43 10.65 72 107540 2937 46575513
Tardive dyskinesia 101.24 10.65 105 107507 7438 46571012
Haemophagocytic lymphohistiocytosis 101.12 10.65 110 107502 8232 46570218
Anticonvulsant drug level increased 100.66 10.65 54 107558 1366 46577084
Face oedema 98.07 10.65 166 107446 18987 46559463
Suicidal behaviour 97.08 10.65 64 107548 2384 46576066
Muscle rigidity 96.53 10.65 117 107495 9844 46568606
Anticonvulsant drug level above therapeutic 96.07 10.65 38 107574 461 46577989
Fatigue 95.88 10.65 920 106692 607777 45970673
Maternal drugs affecting foetus 94.96 10.65 88 107524 5430 46573020
Chest pain 94.78 10.65 163 107449 176161 46402289
Neuroleptic malignant syndrome 94.00 10.65 122 107490 11000 46567450
Cognitive disorder 93.16 10.65 239 107373 36644 46541806
Febrile neutropenia 93.13 10.65 51 107561 94576 46483874
Pyrexia 92.72 10.65 1218 106394 347584 46230866
Meningitis aseptic 92.58 10.65 76 107536 3983 46574467
Abdominal discomfort 90.49 10.65 130 107482 151035 46427415
Gastrointestinal haemorrhage 89.77 10.65 33 107579 77340 46501110
Anxiety 88.38 10.65 719 106893 181238 46397212
Drug intolerance 87.49 10.65 127 107485 146922 46431528
Sedation 85.16 10.65 173 107439 22737 46555713
Malignant neoplasm progression 83.66 10.65 23 107589 64903 46513547
Hypogammaglobulinaemia 82.70 10.65 81 107531 5357 46573093
Sinusitis 82.29 10.65 107 107505 129661 46448789
Exposure via breast milk 80.96 10.65 46 107566 1306 46577144
Anger 80.54 10.65 117 107495 11735 46566715
Plasma cell myeloma 79.54 10.65 6 107606 44472 46533978
Bronchitis 78.52 10.65 77 107535 105902 46472548
Multiple-drug resistance 78.09 10.65 57 107555 2508 46575942
Toxic skin eruption 78.03 10.65 118 107494 12269 46566181
Infection 77.88 10.65 117 107495 133475 46444975
Caesarean section 77.31 10.65 138 107474 16465 46561985
Hypertension 77.08 10.65 216 107396 196140 46382310
Electroencephalogram abnormal 76.76 10.65 66 107546 3688 46574762
Blood pressure increased 75.73 10.65 109 107503 126557 46451893
Swelling 75.57 10.65 106 107506 124405 46454045
Hyperkalaemia 75.38 10.65 13 107599 50696 46527754
Bipolar I disorder 75.24 10.65 46 107566 1500 46576950
Mood altered 75.07 10.65 119 107493 12888 46565562
Neuropathy peripheral 73.35 10.65 61 107551 90832 46487618
Extrapyramidal disorder 73.34 10.65 109 107503 11159 46567291
Live birth 73.16 10.65 104 107508 10226 46568224
Depressed mood 73.15 10.65 205 107407 33114 46545336
Nausea 71.80 10.65 1135 106477 686319 45892131
Eosinophilia 70.11 10.65 144 107468 19073 46559377
Arthritis 68.65 10.65 47 107565 77269 46501181
Haemoglobin decreased 67.63 10.65 121 107491 128828 46449622
Abdominal pain 67.34 10.65 287 107325 229744 46348706
Hand deformity 66.88 10.65 3 107609 34571 46543879
Therapeutic response unexpected 66.65 10.65 125 107487 15491 46562959
Cardiac failure 66.57 10.65 52 107560 79896 46498554
Myocardial infarction 66.49 10.65 76 107536 97452 46480998
Herpes zoster 66.17 10.65 37 107575 67835 46510615
Chronic obstructive pulmonary disease 66.14 10.65 25 107587 57608 46520842
Hallucination, auditory 65.68 10.65 101 107511 10655 46567795
Delusion 65.45 10.65 103 107509 11085 46567365
Epileptic aura 65.33 10.65 18 107594 59 46578391
Drug level increased 64.71 10.65 136 107476 18305 46560145
Small for dates baby 64.52 10.65 59 107553 3578 46574872
Musculoskeletal pain 64.47 10.65 41 107571 70087 46508363
Hypomania 64.20 10.65 64 107548 4324 46574126
Cerebrovascular accident 63.34 10.65 84 107528 100955 46477495
Obsessive-compulsive disorder 62.66 10.65 55 107557 3160 46575290
Mood swings 61.92 10.65 124 107488 16128 46562322
Asthenia 61.54 10.65 442 107170 310633 46267817
Suspected suicide 60.97 10.65 64 107548 4597 46573853
Behaviour disorder 60.66 10.65 44 107568 1917 46576533
Injection site erythema 59.98 10.65 50 107562 74377 46504073
Coronary artery disease 59.10 10.65 5 107607 33747 46544703
Talipes 58.77 10.65 38 107574 1369 46577081
Foetal anticonvulsant syndrome 58.47 10.65 26 107586 430 46578020
Cardio-respiratory arrest 58.35 10.65 283 107329 59586 46518864
Psychomotor hyperactivity 58.32 10.65 90 107522 9523 46568927
Renal failure 58.30 10.65 108 107504 113486 46464964
Dehydration 57.89 10.65 182 107430 159358 46419092
Affective disorder 57.50 10.65 63 107549 4752 46573698
Asthma 57.48 10.65 76 107536 91466 46486984
Rash macular 57.36 10.65 133 107479 19127 46559323
Rash papular 57.25 10.65 105 107507 12793 46565657
Atonic seizures 56.74 10.65 28 107584 592 46577858
Lower respiratory tract infection 56.70 10.65 28 107584 55061 46523389
Coordination abnormal 56.19 10.65 95 107517 10854 46567596
Temporal lobe epilepsy 56.15 10.65 24 107588 359 46578091
Akathisia 55.13 10.65 78 107534 7636 46570814
Enanthema 55.02 10.65 25 107587 436 46578014
Congenital choroid plexus cyst 54.96 10.65 22 107590 276 46578174
Unresponsive to stimuli 54.71 10.65 181 107431 31993 46546457
Osteoarthritis 54.67 10.65 38 107574 61987 46516463
Inappropriate antidiuretic hormone secretion 54.21 10.65 108 107504 13994 46564456
Sepsis 53.80 10.65 149 107463 135865 46442585
Accidental exposure to product by child 53.59 10.65 33 107579 1090 46577360
Electrocardiogram QT prolonged 53.20 10.65 247 107365 51078 46527372
Injection site pain 53.13 10.65 104 107508 107048 46471402
Dyskinesia 53.06 10.65 167 107445 28758 46549692
Maternal exposure during breast feeding 52.94 10.65 47 107565 2742 46575708
Psychomotor retardation 52.64 10.65 50 107562 3183 46575267
Dyspnoea exertional 52.61 10.65 25 107587 50264 46528186
Drug clearance increased 52.55 10.65 16 107596 81 46578369
Trichiasis 52.52 10.65 15 107597 58 46578392
Balance disorder 52.48 10.65 290 107322 64231 46514219
Diverticulitis 52.47 10.65 7 107605 33032 46545418
Fluid retention 52.45 10.65 26 107586 51020 46527430
Malaise 51.75 10.65 501 107111 330731 46247719
Blister 51.70 10.65 222 107390 44409 46534041
Cardiac arrest 50.94 10.65 370 107242 90029 46488421
Speech disorder 50.77 10.65 191 107421 35976 46542474
Deep vein thrombosis 50.32 10.65 66 107546 79707 46498743
Restlessness 50.20 10.65 151 107461 25373 46553077
Human herpesvirus 6 infection 50.11 10.65 43 107569 2396 46576054
Treatment failure 50.02 10.65 86 107526 93001 46485449
Abdominal pain upper 49.78 10.65 170 107442 145135 46433315
Partial seizures with secondary generalisation 49.57 10.65 21 107591 307 46578143
Oculomucocutaneous syndrome 49.46 10.65 17 107595 134 46578316
Cheilitis 49.05 10.65 53 107559 3935 46574515
Pain in jaw 48.67 10.65 14 107598 38358 46540092
Respiratory arrest 48.64 10.65 180 107432 33636 46544814
Constipation 48.61 10.65 221 107391 173876 46404574
Premature baby 48.48 10.65 120 107492 17992 46560458
Mobility decreased 48.46 10.65 41 107571 60553 46517897
Stillbirth 48.42 10.65 67 107545 6424 46572026
Mental disorder 48.26 10.65 137 107475 22288 46556162
Dystonia 47.90 10.65 90 107522 11167 46567283
Lactic acidosis 47.62 10.65 10 107602 33899 46544551
Infarction 46.13 10.65 40 107572 2261 46576189
Pregnancy on oral contraceptive 46.04 10.65 32 107580 1302 46577148
Tic 45.85 10.65 31 107581 1205 46577245
Inappropriate affect 45.79 10.65 27 107585 823 46577627
Skin degenerative disorder 45.68 10.65 9 107603 0 46578450
Intentional product use issue 45.64 10.65 33 107579 52747 46525703
Rash erythematous 45.42 10.65 178 107434 34172 46544278
Tachycardia 45.27 10.65 388 107224 99234 46479216
Patent ductus arteriosus 45.20 10.65 50 107562 3812 46574638
Drug abuse 45.06 10.65 275 107337 63133 46515317
Abdominal distension 44.93 10.65 62 107550 73289 46505161
Coarctation of the aorta 44.89 10.65 23 107589 528 46577922
Developmental hip dysplasia 44.80 10.65 31 107581 1252 46577198
Impulsive behaviour 44.61 10.65 33 107579 1482 46576968
Eyelid erosion 43.86 10.65 12 107600 38 46578412
Therapeutic response changed 43.77 10.65 25 107587 717 46577733
Autism spectrum disorder 43.70 10.65 23 107589 559 46577891
Sopor 43.52 10.65 122 107490 19706 46558744
Cyanosis neonatal 43.44 10.65 17 107595 200 46578250
Intellectual disability 42.99 10.65 24 107588 658 46577792
Lip ulceration 42.98 10.65 34 107578 1689 46576761
Oedema peripheral 42.66 10.65 206 107406 159500 46418950
Alopecia 42.51 10.65 211 107401 162203 46416247
Productive cough 42.19 10.65 33 107579 50682 46527768
Mucosal disorder 42.06 10.65 35 107577 1869 46576581
Dizziness 42.03 10.65 1054 106558 339360 46239090
Dysmorphism 42.02 10.65 35 107577 1872 46576578
Hydrops foetalis 41.63 10.65 19 107593 335 46578115
Apathy 41.26 10.65 66 107546 7202 46571248
Oculogyric crisis 41.21 10.65 29 107583 1204 46577246
Muscle twitching 41.17 10.65 99 107513 14573 46563877
Conjunctival abrasion 41.16 10.65 11 107601 31 46578419
Agitation neonatal 40.91 10.65 21 107591 484 46577966
Influenza 40.58 10.65 91 107521 89179 46489271
Rash vesicular 40.56 10.65 45 107567 3442 46575008
Tubulointerstitial nephritis and uveitis syndrome 40.55 10.65 14 107598 112 46578338
Cellulitis 40.51 10.65 62 107550 70226 46508224
Pleurothotonus 40.33 10.65 28 107584 1137 46577313
Thrombosis 40.07 10.65 42 107570 56027 46522423
Hypotonia neonatal 39.82 10.65 25 107587 855 46577595
Drug dose titration not performed 39.46 10.65 19 107593 380 46578070
Chest discomfort 39.44 10.65 94 107518 90175 46488275
Logorrhoea 39.39 10.65 37 107575 2322 46576128
Pulmonary oedema 39.15 10.65 36 107576 51069 46527381
Vertigo 39.07 10.65 229 107383 51819 46526631
Thinking abnormal 38.73 10.65 76 107536 9738 46568712
Simple partial seizures 38.45 10.65 21 107591 551 46577899
Lymphocyte morphology abnormal 38.27 10.65 19 107593 407 46578043
Mental impairment 38.18 10.65 87 107525 12369 46566081
Ureteric perforation 38.06 10.65 8 107604 3 46578447
Conjunctivitis 37.96 10.65 99 107513 15325 46563125
Urinary tract infection 37.89 10.65 325 107287 219941 46358509
Catatonia 37.78 10.65 45 107567 3717 46574733
Femur fracture 37.77 10.65 19 107593 36978 46541472
Pulmonary arterial hypertension 37.77 10.65 7 107605 25921 46552529
Osteonecrosis of jaw 37.71 10.65 16 107596 34386 46544064
Papule 37.68 10.65 48 107564 4247 46574203
Blood pressure systolic increased 37.45 10.65 10 107602 28777 46549673
Poisoning deliberate 37.05 10.65 66 107546 7860 46570590
Tonic convulsion 36.93 10.65 26 107586 1080 46577370
Rapid eye movement sleep behaviour disorder 36.86 10.65 14 107598 151 46578299
Gestational diabetes 36.20 10.65 62 107550 7157 46571293
Renal impairment 36.15 10.65 73 107539 74299 46504151
Dyspepsia 36.10 10.65 64 107548 68408 46510042
Weight decreased 35.87 10.65 312 107300 210537 46367913
Mucosal erosion 35.76 10.65 28 107584 1370 46577080
Melaena 35.46 10.65 10 107602 27762 46550688
Neonatal respiratory distress syndrome 35.33 10.65 36 107576 2497 46575953
Traumatic coma 35.30 10.65 11 107601 61 46578389
Eosinophil percentage increased 35.29 10.65 23 107589 840 46577610
Oral disorder 35.12 10.65 64 107548 7758 46570692
Benzodiazepine drug level increased 34.95 10.65 14 107598 176 46578274
Mydriasis 34.92 10.65 76 107536 10477 46567973
Acute myocardial infarction 34.75 10.65 15 107597 31909 46546541
Hypertonia 34.67 10.65 47 107565 4419 46574031
Rectal haemorrhage 34.29 10.65 23 107589 38232 46540218
Haemoptysis 34.25 10.65 9 107603 26180 46552270
Bradycardia neonatal 34.20 10.65 20 107592 600 46577850
Hypotonia 34.03 10.65 65 107547 8164 46570286
Metastases to liver 34.02 10.65 3 107609 19582 46558868
Hallucination 33.83 10.65 214 107398 49737 46528713
Tonsillar hypertrophy 33.79 10.65 22 107590 802 46577648
Lung disorder 33.78 10.65 30 107582 43274 46535176
Depressive symptom 33.68 10.65 37 107575 2799 46575651
Product dispensing error 33.45 10.65 69 107543 9164 46569286
Pleural effusion 33.44 10.65 90 107522 82862 46495588
Angiofibroma 33.42 10.65 12 107600 109 46578341
Antipsychotic drug level increased 33.41 10.65 39 107573 3153 46575297
Neoplasm progression 33.35 10.65 10 107602 26673 46551777
Persecutory delusion 33.27 10.65 35 107577 2520 46575930
Neutropenia 33.06 10.65 194 107418 143010 46435440
Congenital anaemia 33.04 10.65 7 107605 3 46578447
Camptocormia 33.02 10.65 14 107598 205 46578245
Wheezing 32.82 10.65 45 107567 53341 46525109
C-reactive protein abnormal 32.62 10.65 5 107607 21265 46557185
Drug withdrawal convulsions 32.46 10.65 26 107586 1315 46577135
Cerebellar syndrome 32.44 10.65 40 107572 3425 46575025
Low set ears 32.38 10.65 15 107597 274 46578176
Full blood count decreased 32.34 10.65 6 107606 22205 46556245
Lymphangioleiomyomatosis 32.34 10.65 13 107599 165 46578285
Microcephaly 32.28 10.65 20 107592 668 46577782
Pulmonary embolism 32.01 10.65 135 107477 108450 46470000
Pyloric stenosis 31.97 10.65 16 107596 349 46578101
Distributive shock 31.93 10.65 18 107594 503 46577947
Altered state of consciousness 31.69 10.65 122 107490 23226 46555224
Mucosal inflammation 31.62 10.65 26 107586 38950 46539500
Exomphalos 31.36 10.65 18 107594 521 46577929
Paranoia 31.36 10.65 73 107539 10524 46567926
Weight gain poor 31.24 10.65 20 107592 708 46577742
Hypoglycaemia neonatal 31.20 10.65 22 107590 916 46577534
Drug hypersensitivity 31.14 10.65 386 107226 243439 46335011
Discomfort 31.11 10.65 37 107575 46633 46531817
Blood lactate dehydrogenase increased 31.07 10.65 111 107501 20389 46558061
Flat affect 31.07 10.65 25 107587 1273 46577177
Epidermal necrosis 31.02 10.65 21 107591 818 46577632
Lymphadenitis 30.96 10.65 34 107578 2571 46575879
Blood creatinine increased 30.71 10.65 83 107529 76320 46502130
Pulmonary hypertension 30.47 10.65 23 107589 35970 46542480
Brain death 30.40 10.65 35 107577 2788 46575662
Unintended pregnancy 30.23 10.65 50 107562 5610 46572840
Purpura 29.91 10.65 69 107543 9889 46568561
Hyperbilirubinaemia neonatal 29.57 10.65 15 107597 337 46578113
Anticonvulsant drug level below therapeutic 29.46 10.65 18 107594 586 46577864
Dysarthria 29.45 10.65 167 107445 37331 46541119
Disorientation 29.38 10.65 165 107447 36753 46541697
Hemivertebra 29.35 10.65 11 107601 114 46578336
Bone pain 29.35 10.65 39 107573 46851 46531599
Peritonitis 29.31 10.65 6 107606 20708 46557742
Placental disorder 29.27 10.65 25 107587 1384 46577066
Exposure via ingestion 29.25 10.65 38 107574 3429 46575021
Nasal congestion 29.13 10.65 41 107571 48072 46530378
Respiratory disorder neonatal 29.11 10.65 21 107591 907 46577543
Blood pressure fluctuation 29.09 10.65 17 107595 30431 46548019
Oesophageal atresia 29.04 10.65 17 107595 511 46577939
Obsessive thoughts 28.95 10.65 17 107595 514 46577936
Skin erosion 28.95 10.65 31 107581 2278 46576172
Erythema of eyelid 28.82 10.65 28 107584 1833 46576617
Injection site bruising 28.63 10.65 24 107588 35612 46542838
Brugada syndrome 28.60 10.65 13 107599 227 46578223
Amnesia 28.59 10.65 179 107433 41452 46536998
Systemic lupus erythematosus 28.37 10.65 68 107544 65112 46513338
Gamma-glutamyltransferase increased 28.06 10.65 146 107466 31594 46546856
Disseminated intravascular coagulation 28.03 10.65 102 107510 18903 46559547
Therapeutic product effect decreased 28.02 10.65 97 107515 82504 46495946
Confusional state 28.01 10.65 521 107091 159371 46419079
Salivary hypersecretion 28.01 10.65 52 107560 6393 46572057
Impaired healing 28.01 10.65 26 107586 36717 46541733
Affect lability 27.96 10.65 59 107553 7961 46570489
Vomiting projectile 27.91 10.65 24 107588 1341 46577109
Ischaemic stroke 27.89 10.65 3 107609 16719 46561731
Drug screen false positive 27.86 10.65 20 107592 857 46577593
Chloropsia 27.80 10.65 8 107604 32 46578418
General physical health deterioration 27.70 10.65 155 107457 115614 46462836
Cystitis 27.61 10.65 34 107578 42207 46536243
Erythema 27.36 10.65 472 107140 142348 46436102
Central nervous system lesion 27.11 10.65 65 107547 9550 46568900
Derealisation 27.10 10.65 19 107593 784 46577666
Interstitial lung disease 27.04 10.65 52 107560 53897 46524553
Cerebral infarction 27.03 10.65 10 107602 23356 46555094
Angina pectoris 26.96 10.65 14 107598 26761 46551689
Abortion missed 26.91 10.65 25 107587 1547 46576903
Gastrointestinal disorder 26.85 10.65 61 107551 59515 46518935
Irregular sleep phase 26.83 10.65 6 107606 5 46578445
Learning disorder 26.78 10.65 15 107597 414 46578036
Dissociation 26.77 10.65 27 107585 1850 46576600
Crying 26.70 10.65 108 107504 21033 46557417
Photophobia 26.69 10.65 84 107528 14460 46563990
Chronic kidney disease 26.61 10.65 33 107579 40838 46537612
Vision blurred 26.60 10.65 291 107321 79417 46499033
Galactorrhoea 26.55 10.65 38 107574 3759 46574691
Product use issue 26.47 10.65 120 107492 94524 46483926
Bipolar II disorder 26.29 10.65 13 107599 276 46578174
Cataract 26.22 10.65 40 107572 45375 46533075
Osteoporosis 26.22 10.65 33 107579 40575 46537875
Memory impairment 26.11 10.65 283 107329 77054 46501396
Ejection fraction decreased 25.79 10.65 5 107607 17932 46560518
Poor sucking reflex 25.77 10.65 11 107601 164 46578286
Seizure cluster 25.65 10.65 11 107601 166 46578284
Neoplasm malignant 25.64 10.65 11 107601 23488 46554962
Bursitis 25.60 10.65 7 107605 19835 46558615
Ascites 25.47 10.65 28 107584 36556 46541894
Spina bifida 25.46 10.65 17 107595 647 46577803
Haemorrhoids 25.43 10.65 6 107606 18771 46559679
Sinus tachycardia 25.30 10.65 108 107504 21541 46556909
Premature labour 25.26 10.65 70 107542 11229 46567221
Muscle spasms 25.22 10.65 173 107439 122940 46455510
Respiratory depression 25.09 10.65 71 107541 11529 46566921
Basal cell carcinoma 25.03 10.65 8 107604 20479 46557971
Hereditary ataxia 24.94 10.65 7 107605 25 46578425
Injection site pruritus 24.93 10.65 33 107579 39710 46538740
Gambling disorder 24.92 10.65 22 107590 1274 46577176
Metastases to bone 24.86 10.65 5 107607 17471 46560979
Fluid overload 24.83 10.65 16 107596 27169 46551281
Euphoric mood 24.53 10.65 39 107573 4233 46574217
Knee arthroplasty 24.39 10.65 12 107600 23653 46554797
Loss of consciousness 24.20 10.65 367 107245 107871 46470579
Cytomegalovirus infection 24.18 10.65 6 107606 18138 46560312
Musculoskeletal stiffness 24.10 10.65 130 107482 97863 46480587
Anomalous pulmonary venous connection 24.09 10.65 8 107604 56 46578394
Neurotoxicity 24.06 10.65 78 107534 13639 46564811
Thyroiditis 24.04 10.65 24 107588 1624 46576826
Flight of ideas 24.01 10.65 13 107599 335 46578115
Plagiocephaly 23.85 10.65 8 107604 58 46578392
Coma scale abnormal 23.81 10.65 42 107570 4964 46573486
Haematochezia 23.65 10.65 31 107581 37462 46540988
Haematemesis 23.64 10.65 19 107593 28787 46549663
Osteomyelitis 23.60 10.65 11 107601 22372 46556078
Wound 23.48 10.65 39 107573 42763 46535687
Electrocardiogram ST segment depression 23.47 10.65 30 107582 2663 46575787
Encephalopathy 23.42 10.65 145 107467 33444 46545006
Hypomagnesaemia 23.29 10.65 11 107601 22199 46556251
Vulvar erosion 23.25 10.65 10 107602 152 46578298
Localised infection 23.15 10.65 13 107599 23788 46554662
Cardiac disorder 23.11 10.65 41 107571 43817 46534633
Treatment noncompliance 23.08 10.65 132 107480 29599 46548851
Acute respiratory distress syndrome 23.08 10.65 106 107506 21816 46556634
Infantile apnoea 23.07 10.65 17 107595 759 46577691
Congenital hand malformation 23.05 10.65 12 107600 285 46578165
Choroidal coloboma 23.03 10.65 5 107607 3 46578447
Congenital anomaly in offspring 23.02 10.65 10 107602 156 46578294
Glossodynia 22.92 10.65 42 107570 44331 46534119
Combined immunodeficiency 22.91 10.65 9 107603 107 46578343
Anaphylactic shock 22.91 10.65 9 107603 20265 46558185
Sleep paralysis 22.88 10.65 14 107598 457 46577993
Resting tremor 22.74 10.65 16 107596 664 46577786
Product dose omission issue 22.56 10.65 264 107348 168256 46410194
Eye movement disorder 22.52 10.65 40 107572 4753 46573697
Illusion 22.48 10.65 19 107593 1037 46577413
Entropion 22.43 10.65 6 107606 17 46578433
Hip arthroplasty 22.25 10.65 7 107605 18105 46560345
Joint range of motion decreased 22.21 10.65 4 107608 15120 46563330
Hypokalaemia 22.08 10.65 116 107496 87908 46490542
Lipids 21.93 10.65 6 107606 19 46578431
Persistent left superior vena cava 21.86 10.65 7 107605 43 46578407
Breast cancer 21.84 10.65 45 107567 45473 46532977
Attention deficit hyperactivity disorder 21.84 10.65 26 107586 2146 46576304
Hospitalisation 21.79 10.65 74 107538 63311 46515139
Psoriasis 21.78 10.65 100 107512 78504 46499946
Palmar-plantar erythrodysaesthesia syndrome 21.64 10.65 10 107602 20441 46558009
Parkinsonism 21.63 10.65 53 107559 7895 46570555
Hallucination, visual 21.54 10.65 90 107522 17783 46560667
Pseudolymphoma 21.52 10.65 15 107597 613 46577837
Colitis 21.46 10.65 33 107579 37314 46541136
Upper gastrointestinal haemorrhage 21.42 10.65 6 107606 16732 46561718
Heart rate increased 21.41 10.65 94 107518 74697 46503753
Pharyngeal erythema 21.39 10.65 22 107590 1543 46576907
Device related infection 21.19 10.65 11 107601 21030 46557420
Self esteem decreased 21.08 10.65 14 107598 528 46577922
Lennox-Gastaut syndrome 20.95 10.65 11 107601 266 46578184
Palpitations 20.95 10.65 131 107481 95128 46483322
Angiomyolipoma 20.95 10.65 10 107602 196 46578254
Cataplexy 20.89 10.65 19 107593 1144 46577306
Lung neoplasm malignant 20.88 10.65 5 107607 15484 46562966
Major depression 20.80 10.65 47 107565 6643 46571807
Educational problem 20.73 10.65 11 107601 272 46578178
Product administration error 20.59 10.65 95 107517 19586 46558864
Conjunctival disorder 20.57 10.65 9 107603 143 46578307
Delivery 20.51 10.65 15 107597 662 46577788
Hyperammonaemia 20.43 10.65 38 107574 4678 46573772
Myocarditis 20.42 10.65 51 107561 7688 46570762
Decreased appetite 20.40 10.65 319 107293 193517 46384933
Cardiac malposition 20.38 10.65 7 107605 55 46578395
Blood pressure diastolic decreased 20.35 10.65 4 107608 14207 46564243
Genital erosion 20.34 10.65 9 107603 147 46578303
Nightmare 20.33 10.65 84 107528 16514 46561936
Lymphocytic infiltration 20.31 10.65 16 107596 790 46577660
Oral hairy leukoplakia 20.30 10.65 4 107608 0 46578450
Illogical thinking 20.27 10.65 7 107605 56 46578394
Gastric disorder 20.23 10.65 19 107593 26686 46551764
Acquired immunodeficiency syndrome 20.23 10.65 8 107604 97 46578353
Dysphemia 20.13 10.65 26 107586 2332 46576118
Coprolalia 20.11 10.65 6 107606 28 46578422
Psoriatic arthropathy 20.09 10.65 33 107579 36346 46542104
Vestibular migraine 20.08 10.65 8 107604 99 46578351
Automatism 19.96 10.65 7 107605 59 46578391
Retinal pigment epitheliopathy 19.90 10.65 10 107602 220 46578230
Transient ischaemic attack 19.90 10.65 31 107581 34872 46543578
Flushing 19.87 10.65 79 107533 64535 46513915
Granulocytopenia 19.81 10.65 40 107572 5233 46573217
Injury corneal 19.75 10.65 7 107605 61 46578389
Retrognathia 19.72 10.65 11 107601 301 46578149
Limbic encephalitis 19.50 10.65 10 107602 230 46578220
Psychiatric decompensation 19.50 10.65 18 107594 1105 46577345
Cholestasis of pregnancy 19.48 10.65 18 107594 1106 46577344
Tricuspid valve incompetence 19.35 10.65 4 107608 13713 46564737
Haematuria 19.32 10.65 20 107592 26838 46551612
Skin ulcer 19.31 10.65 28 107584 32430 46546020
Breast cancer metastatic 19.27 10.65 4 107608 13674 46564776
Speech disorder developmental 19.26 10.65 12 107600 405 46578045
Injection site swelling 19.24 10.65 40 107572 40287 46538163
Hypocalcaemia 19.20 10.65 20 107592 26765 46551685
Lymphocyte stimulation test positive 19.18 10.65 14 107598 616 46577834
Persistent depressive disorder 19.10 10.65 17 107595 995 46577455
Aphasia 19.10 10.65 122 107490 28445 46550005
Congenital aortic valve stenosis 19.08 10.65 7 107605 68 46578382
Sciatica 19.07 10.65 10 107602 19010 46559440
Stereotypy 18.94 10.65 12 107600 417 46578033
Staring 18.90 10.65 20 107592 1450 46577000
Echolalia 18.87 10.65 9 107603 176 46578274
Hip fracture 18.85 10.65 20 107592 26536 46551914
Symblepharon 18.81 10.65 7 107605 71 46578379
Myalgia 18.81 10.65 187 107425 122901 46455549
Mitral valve incompetence 18.77 10.65 10 107602 18842 46559608
Disinhibition 18.59 10.65 16 107596 895 46577555
Sleep disorder 18.55 10.65 177 107435 46618 46531832
Gastric ulcer 18.47 10.65 14 107598 21849 46556601
Foetal death 18.41 10.65 53 107559 8690 46569760
Transfusion 18.38 10.65 4 107608 13227 46565223
Change in seizure presentation 18.32 10.65 10 107602 262 46578188
Septic shock 18.30 10.65 70 107542 57823 46520627
Haematocrit decreased 18.26 10.65 33 107579 35024 46543426
Heart rate decreased 18.25 10.65 28 107584 31695 46546755
Histiocytosis 18.24 10.65 5 107607 16 46578434
Mouth ulceration 18.19 10.65 115 107497 26717 46551733
Retinogram abnormal 18.12 10.65 8 107604 130 46578320
Flatulence 18.09 10.65 24 107588 28854 46549596
Arnold-Chiari malformation 18.06 10.65 12 107600 453 46577997
Drooling 18.02 10.65 29 107583 3180 46575270
Postictal psychosis 18.01 10.65 5 107607 17 46578433
Lipids abnormal 17.89 10.65 10 107602 275 46578175
Withdrawal syndrome 17.86 10.65 86 107526 18048 46560402
Iris coloboma 17.83 10.65 6 107606 44 46578406
Cardiomegaly 17.81 10.65 9 107603 17473 46560977
Hiatus hernia 17.80 10.65 10 107602 18292 46560158
Congenital anomaly 17.79 10.65 20 107592 1552 46576898
Hepatic function abnormal 17.74 10.65 138 107474 34283 46544167
Osteochondrosis 17.72 10.65 16 107596 954 46577496
Myelodysplastic syndrome 17.71 10.65 7 107605 15704 46562746
Hippocampal sclerosis 17.62 10.65 7 107605 86 46578364
Scab 17.61 10.65 44 107568 6635 46571815
Oedema 17.60 10.65 87 107525 66984 46511466
Self-injurious ideation 17.55 10.65 24 107588 2276 46576174
Fibromyalgia 17.54 10.65 36 107576 36427 46542023
Blood glucose increased 17.45 10.65 96 107516 71917 46506533
Tension 17.44 10.65 27 107585 2865 46575585
Platelet count decreased 17.43 10.65 147 107465 99877 46478573
Postictal state 17.43 10.65 16 107596 975 46577475
Negativism 17.40 10.65 11 107601 381 46578069
Meningomyelocele 17.36 10.65 12 107600 484 46577966
Tachyphrenia 17.34 10.65 18 107594 1276 46577174
Overweight 17.30 10.65 28 107584 3085 46575365
Concussion 17.28 10.65 45 107567 6958 46571492
Decreased eye contact 17.26 10.65 7 107605 91 46578359
Oral mucosal blistering 17.23 10.65 36 107576 4824 46573626
Alopecia universalis 17.19 10.65 7 107605 92 46578358
Suicide threat 17.18 10.65 5 107607 21 46578429
Hyperprolactinaemia 17.16 10.65 27 107585 2905 46575545
Sleep-related eating disorder 17.15 10.65 13 107599 606 46577844
Mononucleosis syndrome 17.13 10.65 8 107604 149 46578301
Throat irritation 17.12 10.65 25 107587 28876 46549574
Injection site reaction 17.04 10.65 55 107557 47794 46530656
Spinal stenosis 17.00 10.65 4 107608 12539 46565911
Tonic clonic movements 16.97 10.65 17 107595 1155 46577295
Upper respiratory tract infection 16.93 10.65 82 107530 63474 46514976
Borderline personality disorder 16.88 10.65 14 107598 744 46577706
Blood pressure decreased 16.87 10.65 71 107541 57088 46521362
Coma scale 16.86 10.65 6 107606 53 46578397
Hypoxia 16.83 10.65 62 107550 51776 46526674
Rhinorrhoea 16.83 10.65 55 107557 47610 46530840
Nephrogenic diabetes insipidus 16.80 10.65 14 107598 749 46577701
Cerebral atrophy 16.80 10.65 35 107577 4681 46573769
Parachute mitral valve 16.80 10.65 7 107605 98 46578352
Cerebellar atrophy 16.75 10.65 13 107599 628 46577822
Dermatitis bullous 16.74 10.65 47 107565 7596 46570854
Cerebellar ataxia 16.69 10.65 15 107597 889 46577561
Photosensitivity reaction 16.67 10.65 66 107546 12726 46565724
Herpangina 16.64 10.65 5 107607 24 46578426
Hostility 16.57 10.65 18 107594 1344 46577106
Periodic limb movement disorder 16.57 10.65 8 107604 161 46578289
Neurosurgery 16.47 10.65 5 107607 25 46578425
Metastases to central nervous system 16.40 10.65 3 107609 11218 46567232
Somnambulism 16.35 10.65 36 107576 5001 46573449
Sinus congestion 16.23 10.65 5 107607 13104 46565346
Suppressed lactation 16.19 10.65 11 107601 431 46578019
Dry skin 16.15 10.65 45 107567 40971 46537479
Alanine aminotransferase increased 16.10 10.65 290 107322 88161 46490289
Pulmonary congestion 16.03 10.65 7 107605 14792 46563658
Bradykinesia 16.00 10.65 31 107581 3935 46574515
Cardiac aneurysm 15.98 10.65 14 107598 802 46577648
Gastrooesophageal reflux disease 15.95 10.65 103 107509 74241 46504209
Abulia 15.90 10.65 10 107602 343 46578107
Spinal compression fracture 15.83 10.65 5 107607 12898 46565552
Foetal heart rate deceleration abnormality 15.79 10.65 11 107601 449 46578001
Cleft lip 15.78 10.65 7 107605 115 46578335
Neonatal tachypnoea 15.77 10.65 6 107606 65 46578385
Lactation disorder 15.76 10.65 9 107603 258 46578192
Night sweats 15.73 10.65 24 107588 27226 46551224
Syncope 15.68 10.65 160 107452 104643 46473807
Gastritis 15.65 10.65 35 107577 34343 46544107
Corneal erosion 15.60 10.65 9 107603 263 46578187
Clostridium difficile colitis 15.52 10.65 12 107600 18541 46559909
Osteonecrosis 15.52 10.65 22 107590 25722 46552728
Psychomotor skills impaired 15.47 10.65 22 107590 2164 46576286
Hypertensive crisis 15.46 10.65 6 107606 13609 46564841
Pre-eclampsia 15.44 10.65 47 107565 7947 46570503
Spinal fracture 15.41 10.65 8 107604 15297 46563153
Rhabdomyolysis 15.38 10.65 156 107456 41753 46536697
Injection site haemorrhage 15.38 10.65 15 107597 20694 46557756
Cerebral ventricle dilatation 15.36 10.65 15 107597 988 46577462
Anorgasmia 15.35 10.65 12 107600 586 46577864
Medication overuse headache 15.33 10.65 11 107601 471 46577979
Retinal coloboma 15.31 10.65 5 107607 33 46578417
Therapeutic product effective for unapproved indication 15.23 10.65 6 107606 72 46578378
Pharyngeal exudate 15.23 10.65 3 107609 0 46578450
Laryngeal tremor 15.23 10.65 3 107609 0 46578450
Fungal infection 15.19 10.65 28 107584 29492 46548958
Brachycephaly 15.18 10.65 5 107607 34 46578416
Brain oedema 15.17 10.65 63 107549 12415 46566035
Gait deviation 15.15 10.65 6 107606 73 46578377
Loss of personal independence in daily activities 15.11 10.65 74 107538 57109 46521341
Developmental delay 15.05 10.65 16 107596 1166 46577284
Off label use 15.03 10.65 719 106893 379122 46199328
Abnormal dreams 15.02 10.65 55 107557 10224 46568226
Dysmetropsia 15.01 10.65 6 107606 75 46578375
Oscillopsia 14.96 10.65 7 107605 131 46578319
Morose 14.94 10.65 5 107607 36 46578414
Hypersensitivity 14.94 10.65 250 107362 150071 46428379
Menstrual disorder 14.93 10.65 31 107581 4137 46574313
Poor feeding infant 14.82 10.65 8 107604 205 46578245
Premature rupture of membranes 14.80 10.65 32 107580 4391 46574059
Blepharospasm 14.80 10.65 22 107590 2252 46576198
Selective IgA immunodeficiency 14.78 10.65 4 107608 12 46578438
International normalised ratio increased 14.62 10.65 57 107555 46826 46531624
Joint stiffness 14.59 10.65 25 107587 27083 46551367
Tuberculosis 14.47 10.65 3 107609 10262 46568188
Lymph node pain 14.46 10.65 16 107596 1220 46577230
Attention-seeking behaviour 14.46 10.65 6 107606 83 46578367
Strabismus 14.38 10.65 19 107593 1743 46576707
Placental infarction 14.36 10.65 9 107603 307 46578143
Heart rate irregular 14.35 10.65 13 107599 18578 46559872
Gastroenteritis 14.30 10.65 21 107591 24198 46554252
Bezoar 14.29 10.65 17 107595 1402 46577048
Urinary retention 14.28 10.65 106 107506 25955 46552495
Conjunctival ulcer 14.27 10.65 5 107607 42 46578408
Cellulitis orbital 14.25 10.65 10 107602 413 46578037
Product quality issue 14.21 10.65 135 107477 35513 46542937
Bacterial infection 14.20 10.65 10 107602 16206 46562244
Colitis ulcerative 14.17 10.65 12 107600 17720 46560730
Aspergillus test positive 14.07 10.65 9 107603 318 46578132
Hallucination, olfactory 14.05 10.65 8 107604 228 46578222
Homicidal ideation 14.04 10.65 19 107593 1783 46576667
Dysphoria 14.00 10.65 32 107580 4557 46573893
Oral mucosal erythema 14.00 10.65 17 107595 1433 46577017
Oesophagitis 13.95 10.65 7 107605 13644 46564806
Panic attack 13.87 10.65 87 107525 20155 46558295
Pregnancy with implant contraceptive 13.87 10.65 20 107592 1992 46576458
Agranulocytosis 13.77 10.65 93 107519 22092 46556358
Oxygen saturation decreased 13.76 10.65 98 107514 69066 46509384
Pigmentation disorder 13.64 10.65 28 107584 3705 46574745
Cogwheel rigidity 13.62 10.65 17 107595 1473 46576977
Skin disorder 13.62 10.65 93 107519 22170 46556280
Transaminases increased 13.59 10.65 110 107502 27651 46550799
Fulminant type 1 diabetes mellitus 13.56 10.65 8 107604 244 46578206
Macule 13.56 10.65 17 107595 1480 46576970
Acute myopia 13.56 10.65 6 107606 98 46578352
Abortion 13.56 10.65 21 107591 2229 46576221
Toothache 13.54 10.65 11 107601 16581 46561869
Pancytopenia 13.50 10.65 128 107484 84930 46493520
Hypercapnic coma 13.49 10.65 7 107605 165 46578285
Conjunctival oedema 13.44 10.65 11 107601 574 46577876
Hypotension 13.42 10.65 421 107191 232168 46346282
Hypoglycaemia 13.41 10.65 72 107540 54277 46524173
Dermatitis exfoliative 13.36 10.65 36 107576 5680 46572770
Delusional disorder, erotomanic type 13.35 10.65 4 107608 19 46578431
Bradyphrenia 13.34 10.65 38 107574 6192 46572258
Hepatitis 13.34 10.65 123 107489 32092 46546358
Pulmonary fibrosis 13.31 10.65 16 107596 20076 46558374
Pregnancy with contraceptive device 13.30 10.65 31 107581 4472 46573978
Respiratory tract infection 13.25 10.65 31 107581 29941 46548509
Roseolovirus test positive 13.24 10.65 5 107607 53 46578397
Body height decreased 13.24 10.65 3 107609 9649 46568801
Intention tremor 13.19 10.65 9 107603 355 46578095
Pulmonary mass 13.18 10.65 13 107599 17844 46560606
Exposure via transplant 13.18 10.65 4 107608 20 46578430
Nodule 13.17 10.65 10 107602 15595 46562855
Congenital ureteric anomaly 13.16 10.65 5 107607 54 46578396
Congenital emphysema 13.15 10.65 3 107609 3 46578447
Congenital oesophageal anomaly 13.15 10.65 3 107609 3 46578447
Blood creatine phosphokinase increased 13.12 10.65 109 107503 27615 46550835
Dysphonia 13.10 10.65 45 107567 38369 46540081
Foetal growth restriction 13.05 10.65 39 107573 6528 46571922
Haemangioma 13.05 10.65 22 107590 2507 46575943
Chills 13.01 10.65 150 107462 95882 46482568
Adrenal insufficiency 13.01 10.65 7 107605 13117 46565333
Eosinophilic myocarditis 13.00 10.65 9 107603 364 46578086
Immunodeficiency 12.98 10.65 7 107605 13099 46565351
Screaming 12.94 10.65 25 107587 3166 46575284
Gout 12.90 10.65 5 107607 11351 46567099
Feeling drunk 12.87 10.65 28 107584 3859 46574591
Anal erosion 12.86 10.65 4 107608 22 46578428
Cardiovascular symptom 12.84 10.65 5 107607 58 46578392
Drug ineffective 12.81 10.65 1368 106244 676470 45901980
Tearfulness 12.80 10.65 29 107583 4106 46574344
Clostridium difficile infection 12.75 10.65 24 107588 25079 46553371
Holoprosencephaly 12.72 10.65 4 107608 23 46578427
Oral mucosal eruption 12.71 10.65 11 107601 620 46577830
Blunted affect 12.70 10.65 7 107605 187 46578263
Hypercalcaemia 12.67 10.65 18 107594 21028 46557422
Hyperventilation 12.64 10.65 35 107577 5612 46572838
Blood prolactin increased 12.63 10.65 24 107588 3003 46575447
Diverticulum 12.62 10.65 5 107607 11201 46567249
Polyhydramnios 12.53 10.65 19 107593 1980 46576470
Emotional poverty 12.50 10.65 8 107604 283 46578167
Hepatosplenomegaly 12.48 10.65 21 107591 2389 46576061
Tonsillar haemorrhage 12.47 10.65 7 107605 194 46578256
Polydipsia 12.47 10.65 25 107587 3254 46575196
Foetal malnutrition 12.46 10.65 6 107606 120 46578330
Social avoidant behaviour 12.46 10.65 23 107589 2816 46575634
Antipsychotic drug level above therapeutic 12.45 10.65 13 107599 928 46577522
Musculoskeletal chest pain 12.45 10.65 14 107598 18092 46560358
Red blood cell sedimentation rate increased 12.42 10.65 21 107591 22868 46555582
Head titubation 12.41 10.65 11 107601 640 46577810
Cytotoxic oedema 12.37 10.65 6 107606 122 46578328
Drug level fluctuating 12.35 10.65 9 107603 395 46578055
Hepatic encephalopathy 12.35 10.65 4 107608 10153 46568297
Flank pain 12.34 10.65 6 107606 11907 46566543
White blood cell count increased 12.34 10.65 156 107456 44063 46534387
Sinus disorder 12.29 10.65 12 107600 16551 46561899
Psychiatric symptom 12.25 10.65 30 107582 4467 46573983
Flashback 12.15 10.65 6 107606 127 46578323
Regressive behaviour 12.13 10.65 5 107607 68 46578382
Device issue 12.12 10.65 17 107595 19963 46558487
Paraesthesia 12.09 10.65 194 107418 117243 46461207
Spinal osteoarthritis 12.03 10.65 9 107603 14142 46564308
Hyperglycaemia 12.01 10.65 41 107571 35030 46543420
Intestinal perforation 11.96 10.65 5 107607 10846 46567604
Atrophy of globe 11.94 10.65 3 107609 6 46578444
Wound healing normal 11.94 10.65 3 107609 6 46578444
Delusional perception 11.94 10.65 7 107605 211 46578239
Poor weight gain neonatal 11.93 10.65 5 107607 71 46578379
Brain malformation 11.93 10.65 4 107608 29 46578421
Skin exfoliation 11.80 10.65 122 107490 32816 46545634
Anaphylactic reaction 11.69 10.65 73 107539 53039 46525411
Lymphoma 11.69 10.65 4 107608 9809 46568641
Tongue eruption 11.69 10.65 5 107607 75 46578375
Metastases to lung 11.68 10.65 5 107607 10691 46567759
Phonophobia 11.61 10.65 8 107604 321 46578129
Skin cancer 11.60 10.65 3 107609 8820 46569630
Clumsiness 11.59 10.65 17 107595 1719 46576731
Bankruptcy 11.59 10.65 4 107608 32 46578418
Homeless 11.59 10.65 4 107608 32 46578418
Bone density decreased 11.58 10.65 4 107608 9748 46568702
Pityriasis rosea 11.57 10.65 5 107607 77 46578373
Eclampsia 11.56 10.65 8 107604 323 46578127
Arteriosclerosis 11.54 10.65 4 107608 9729 46568721
Tooth infection 11.54 10.65 7 107605 12279 46566171
Gestational hypertension 11.46 10.65 19 107593 2136 46576314
Epistaxis 11.43 10.65 94 107518 64211 46514239
Initial insomnia 11.39 10.65 29 107583 4423 46574027
Psychogenic seizure 11.38 10.65 14 107598 1196 46577254
Pneumocystis jirovecii pneumonia 11.37 10.65 11 107601 15237 46563213
Cardiovascular disorder 11.37 10.65 7 107605 12180 46566270
White blood cell count decreased 11.36 10.65 186 107426 112045 46466405
Monocyte percentage increased 11.35 10.65 13 107599 1030 46577420
Contusion 11.33 10.65 138 107474 87349 46491101
Normal newborn 11.33 10.65 35 107577 5966 46572484
Retroperitoneal fibrosis 11.31 10.65 8 107604 335 46578115
Inflammation 11.29 10.65 66 107546 48715 46529735
Stupor 11.25 10.65 25 107587 3495 46574955
Excessive eye blinking 11.24 10.65 10 107602 585 46577865
Bone disorder 11.22 10.65 18 107594 20015 46558435
Renal injury 11.18 10.65 4 107608 9537 46568913
Injection site rash 11.12 10.65 12 107600 15801 46562649
Hyperphagia 11.11 10.65 16 107596 1592 46576858
Head circumference abnormal 11.09 10.65 3 107609 9 46578441
Congenital coronary artery malformation 11.08 10.65 4 107608 37 46578413
Cerebellar hypoplasia 11.07 10.65 5 107607 86 46578364
Skin lesion 11.06 10.65 102 107510 26611 46551839
Joint effusion 11.04 10.65 7 107605 11988 46566462
Psychotic symptom 11.03 10.65 12 107600 898 46577552
Economic problem 11.00 10.65 18 107594 2002 46576448
Miosis 10.91 10.65 37 107575 6620 46571830
Drug resistance 10.89 10.65 73 107539 17295 46561155
Blood iron decreased 10.88 10.65 6 107606 11091 46567359
Delusion of reference 10.86 10.65 5 107607 90 46578360
Eyelid oedema 10.84 10.65 50 107562 10307 46568143
Cholelithiasis 10.84 10.65 49 107563 38632 46539818
Malignant melanoma 10.83 10.65 5 107607 10229 46568221
Ear infection 10.83 10.65 23 107589 22990 46555460
Libido increased 10.82 10.65 11 107601 761 46577689
Acute coronary syndrome 10.78 10.65 5 107607 10199 46568251
Viral rash 10.76 10.65 7 107605 255 46578195
Anticonvulsant drug level abnormal 10.71 10.65 4 107608 41 46578409
Blood magnesium decreased 10.70 10.65 6 107606 10986 46567464
Lip disorder 10.66 10.65 13 107599 1100 46577350
Multiple organ dysfunction syndrome 10.66 10.65 173 107439 51537 46526913

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1518.78 11.95 1359 56333 97116 29797670
Foetal exposure during pregnancy 901.10 11.95 667 57025 36204 29858582
Epilepsy 600.94 11.95 412 57280 19757 29875029
Stevens-Johnson syndrome 576.61 11.95 381 57311 17175 29877611
Completed suicide 478.76 11.95 758 56934 98734 29796052
Drug reaction with eosinophilia and systemic symptoms 420.90 11.95 385 57307 28103 29866683
Generalised tonic-clonic seizure 420.34 11.95 328 57364 19223 29875563
Product substitution issue 381.80 11.95 239 57453 9796 29884990
Status epilepticus 367.57 11.95 242 57450 10830 29883956
Toxicity to various agents 353.74 11.95 937 56755 176246 29718540
Exposure during pregnancy 328.45 11.95 211 57481 9050 29885736
Ataxia 308.22 11.95 220 57472 11242 29883544
Aggression 299.06 11.95 362 57330 36545 29858241
Atrial septal defect 233.46 11.95 151 57541 6550 29888236
Toxic epidermal necrolysis 211.05 11.95 214 57478 17726 29877060
Suicide attempt 209.18 11.95 303 57389 36394 29858392
Agitation 207.63 11.95 373 57319 53700 29841086
Diarrhoea 188.96 11.95 220 57472 333883 29560903
Rash 183.54 11.95 793 56899 191096 29703690
Dyspnoea 181.53 11.95 226 57466 333069 29561717
Febrile neutropenia 178.65 11.95 6 57686 106687 29788099
Somnolence 167.92 11.95 487 57205 96276 29798510
Pneumonia 158.74 11.95 250 57442 334056 29560730
Death 155.14 11.95 283 57409 357000 29537786
Acute kidney injury 147.55 11.95 187 57505 273655 29621131
Drug interaction 147.14 11.95 765 56927 198803 29695983
Intentional overdose 145.14 11.95 275 57417 41206 29853580
Abnormal behaviour 145.13 11.95 211 57481 25412 29869374
Anaemia 141.55 11.95 116 57576 207876 29686910
Partial seizures 141.42 11.95 89 57603 3678 29891108
Irritability 138.16 11.95 195 57497 22855 29871931
Mania 137.56 11.95 125 57567 9029 29885757
Myocardial infarction 133.98 11.95 38 57654 125587 29769199
Neonatal respiratory distress syndrome 133.85 11.95 88 57604 3924 29890862
Autism spectrum disorder 132.03 11.95 60 57632 1265 29893521
Cardiac failure congestive 127.74 11.95 9 57683 84398 29810388
Maternal exposure during breast feeding 126.05 11.95 62 57630 1570 29893216
Hypospadias 125.61 11.95 73 57619 2606 29892180
Dysmorphism 124.87 11.95 66 57626 1951 29892835
Exposure via breast milk 122.25 11.95 60 57632 1512 29893274
Sudden unexplained death in epilepsy 118 11.95 41 57651 409 29894377
Petit mal epilepsy 116.28 11.95 69 57623 2562 29892224
Ventricular septal defect 109.52 11.95 74 57618 3455 29891331
Maternal drugs affecting foetus 107.94 11.95 79 57613 4194 29890592
Drug withdrawal syndrome neonatal 104.36 11.95 69 57623 3106 29891680
Attention deficit hyperactivity disorder 102.59 11.95 56 57636 1768 29893018
Myoclonus 100.33 11.95 126 57566 13186 29881600
Selective eating disorder 98.33 11.95 53 57639 1631 29893155
Bipolar disorder 98.08 11.95 71 57621 3705 29891081
Neurodevelopmental disorder 97.89 11.95 28 57664 136 29894650
Overdose 96.57 11.95 369 57323 83968 29810818
Conjunctival hyperaemia 96.41 11.95 58 57634 2209 29892577
Drug eruption 95.86 11.95 142 57550 17384 29877402
Rash maculo-papular 94.47 11.95 173 57519 25245 29869541
Hypotonia neonatal 94.40 11.95 44 57648 985 29893801
Patent ductus arteriosus 92.53 11.95 64 57628 3105 29891681
Maternal exposure during pregnancy 92.02 11.95 69 57623 3802 29890984
Agitation neonatal 91.47 11.95 43 57649 982 29893804
Respiratory disorder neonatal 91.35 11.95 45 57647 1143 29893643
Oculogyric crisis 90.85 11.95 47 57645 1328 29893458
Congenital anomaly 89.69 11.95 46 57646 1276 29893510
Hypomania 88.97 11.95 55 57637 2201 29892585
Coma 88.55 11.95 222 57470 40227 29854559
Brugada syndrome 88.50 11.95 36 57656 572 29894214
Electrocardiogram QRS complex prolonged 88.05 11.95 70 57622 4207 29890579
Atrial fibrillation 85.72 11.95 51 57641 108073 29786713
Pain 84.62 11.95 126 57566 172515 29722271
Oral mucosa erosion 84.54 11.95 38 57654 780 29894006
Malignant neoplasm progression 84.54 11.95 18 57674 72269 29822517
Speech disorder developmental 82.82 11.95 42 57650 1137 29893649
Lip erosion 81.65 11.95 34 57658 575 29894211
Infantile apnoea 81.51 11.95 38 57654 851 29893935
Arthralgia 81.28 11.95 85 57607 135706 29759080
Intentional self-injury 80.35 11.95 114 57578 13418 29881368
Accidental exposure to product by child 79.73 11.95 45 57647 1518 29893268
Crying 79.23 11.95 74 57618 5535 29889251
Focal dyscognitive seizures 78.56 11.95 42 57650 1271 29893515
Aura 77.38 11.95 27 57665 273 29894513
Interstitial lung disease 76.82 11.95 12 57680 60185 29834601
Cardiac failure 75.58 11.95 33 57659 83385 29811401
Haemophagocytic lymphohistiocytosis 74.30 11.95 93 57599 9698 29885088
Electroencephalogram abnormal 74.19 11.95 50 57642 2324 29892462
Coronary artery disease 73.20 11.95 6 57686 49706 29845080
Cognitive disorder 71.87 11.95 148 57544 23542 29871244
Suicidal ideation 70.61 11.95 190 57502 35924 29858862
Psychomotor hyperactivity 70.35 11.95 83 57609 8141 29886645
Hypotension 69.22 11.95 180 57512 200385 29694401
Developmental delay 69.09 11.95 46 57646 2095 29892691
Obsessive-compulsive disorder 67.06 11.95 59 57633 4082 29890704
Premature baby 66.35 11.95 117 57575 16574 29878212
Plasma cell myeloma 65.25 11.95 12 57680 53450 29841336
Cough 65.19 11.95 88 57604 125554 29769232
Sepsis 64.08 11.95 115 57577 146280 29748506
Sedation 62.81 11.95 113 57579 16260 29878526
Tubulointerstitial nephritis and uveitis syndrome 62.39 11.95 15 57677 30 29894756
Conjunctivitis 62.32 11.95 77 57615 7923 29886863
Restlessness 61.40 11.95 135 57557 22464 29872322
Abdominal pain 60.77 11.95 105 57587 135549 29759237
Pain in extremity 60.47 11.95 74 57618 110147 29784639
Oedema peripheral 60.26 11.95 69 57623 105763 29789023
Disease progression 60.08 11.95 40 57652 79834 29814952
Cerebrovascular accident 59.89 11.95 44 57648 83433 29811353
Talipes 58.96 11.95 38 57654 1637 29893149
Pulmonary embolism 58.94 11.95 39 57653 78096 29816690
Gastrointestinal haemorrhage 58.56 11.95 45 57647 83401 29811385
Haemoglobin decreased 58.09 11.95 81 57611 114017 29780769
Tardive dyskinesia 57.04 11.95 59 57633 4998 29889788
Bradycardia neonatal 56.77 11.95 30 57662 886 29893900
Acute myocardial infarction 56.40 11.95 16 57676 52923 29841863
Joint swelling 56.31 11.95 11 57681 46935 29847851
Back pain 56.15 11.95 69 57623 102527 29792259
Learning disorder 55.28 11.95 24 57668 452 29894334
Antipsychotic drug level increased 55.10 11.95 47 57645 3119 29891667
Mydriasis 54.21 11.95 63 57629 6080 29888706
Tremor 53.97 11.95 287 57405 75076 29819710
Infection 53.65 11.95 43 57649 78031 29816755
Anger 53.62 11.95 85 57607 11035 29883751
Hypoplastic left heart syndrome 53.02 11.95 19 57673 209 29894577
Accidental overdose 52.89 11.95 112 57580 18163 29876623
Neonatal behavioural syndrome 52.57 11.95 16 57676 100 29894686
Balance disorder 52.30 11.95 172 57520 36321 29858465
Psychomotor retardation 51.26 11.95 40 57652 2339 29892447
Cleft lip and palate 51.08 11.95 20 57672 286 29894500
Dystonia 50.60 11.95 77 57615 9650 29885136
Apathy 50.19 11.95 61 57631 6171 29888615
Disturbance in attention 50.03 11.95 123 57569 22006 29872780
Therapeutic response unexpected 49.92 11.95 73 57619 8830 29885956
Asthenia 49.86 11.95 238 57454 221052 29673734
Hypertension 49.85 11.95 99 57593 121255 29773531
Multiple-drug resistance 49.84 11.95 43 57649 2898 29891888
Nystagmus 49.63 11.95 51 57641 4287 29890499
Pleural effusion 49.39 11.95 42 57650 74024 29820762
Depression 48.99 11.95 320 57372 90117 29804669
Psychotic disorder 48.02 11.95 119 57573 21396 29873390
Neuroleptic malignant syndrome 47.31 11.95 100 57592 16195 29878591
Hyperkalaemia 47.07 11.95 35 57657 65975 29828811
Foetal anticonvulsant syndrome 46.98 11.95 25 57667 749 29894037
Neuropathy peripheral 46.95 11.95 40 57652 70435 29824351
Cleft palate 46.66 11.95 23 57669 585 29894201
Nausea 46.16 11.95 359 57333 296598 29598188
Anomaly of external ear congenital 45.66 11.95 15 57677 124 29894662
Partial seizures with secondary generalisation 45.52 11.95 17 57675 212 29894574
Depressive symptom 45.18 11.95 32 57660 1613 29893173
Renal failure 44.99 11.95 115 57577 128851 29765935
Platelet count decreased 44.95 11.95 85 57607 106044 29788742
Poisoning 44.22 11.95 79 57613 11303 29883483
General physical health deterioration 44.15 11.95 78 57614 99866 29794920
Dyspraxia 43.55 11.95 17 57675 241 29894545
Dysarthria 43.05 11.95 143 57549 30347 29864439
Erythema multiforme 42.65 11.95 64 57628 7921 29886865
Blister 42.63 11.95 111 57581 20572 29874214
Chronic obstructive pulmonary disease 42.15 11.95 18 57674 46108 29848678
Diplopia 41.71 11.95 86 57606 13686 29881100
Respiratory failure 41.41 11.95 82 57610 100560 29794226
Delusion 41.29 11.95 79 57613 11910 29882876
Postictal paralysis 41.18 11.95 14 57678 130 29894656
Weight decreased 40.96 11.95 151 57541 150770 29744016
Logorrhoea 40.57 11.95 33 57659 2049 29892737
Haemorrhage 40.51 11.95 19 57673 46060 29848726
Bipolar I disorder 40.48 11.95 23 57669 786 29894000
Fatigue 40.44 11.95 409 57283 320264 29574522
Neutropenia 40.09 11.95 121 57571 128419 29766367
Dyskinesia 39.80 11.95 112 57580 21722 29873064
Nasal septum disorder 39.60 11.95 11 57681 47 29894739
Microcephaly 39.41 11.95 21 57671 631 29894155
Infusion related reaction 38.41 11.95 15 57677 40549 29854237
Behaviour disorder 38.33 11.95 34 57658 2378 29892408
Drug titration error 38.29 11.95 18 57674 411 29894375
Herpes zoster 38.12 11.95 6 57686 29937 29864849
Chest pain 37.93 11.95 109 57583 117518 29777268
Peripheral swelling 37.90 11.95 37 57655 61037 29833749
Epistaxis 37.89 11.95 28 57664 52953 29841833
Renal impairment 37.81 11.95 65 57627 84119 29810667
Limb reduction defect 37.61 11.95 14 57678 173 29894613
Mucosal disorder 37.40 11.95 28 57664 1539 29893247
Postictal psychosis 37.09 11.95 12 57680 94 29894692
Eyelid erosion 36.78 11.95 7 57685 0 29894786
Staring 36.35 11.95 27 57665 1466 29893320
Psychomotor skills impaired 35.71 11.95 30 57662 1949 29892837
Decreased appetite 35.63 11.95 158 57534 149752 29745034
Mood altered 35.63 11.95 60 57632 8190 29886596
Angular cheilitis 35.43 11.95 12 57680 110 29894676
Tic 35.02 11.95 30 57662 2002 29892784
Body dysmorphic disorder 34.95 11.95 11 57681 78 29894708
Hypoglycaemia neonatal 34.94 11.95 27 57665 1556 29893230
Tonic clonic movements 34.86 11.95 23 57669 1031 29893755
Sinus tachycardia 34.86 11.95 86 57606 15418 29879368
Overweight 34.57 11.95 26 57666 1439 29893347
Burnout syndrome 34.51 11.95 12 57680 120 29894666
Erythema of eyelid 34.49 11.95 19 57673 611 29894175
Hallucination, auditory 34.32 11.95 65 57627 9724 29885062
Retrognathia 34.21 11.95 14 57678 226 29894560
Memory impairment 34.08 11.95 152 57540 37022 29857764
Anticonvulsant drug level increased 33.79 11.95 26 57666 1489 29893297
Dyspnoea exertional 33.71 11.95 13 57679 35417 29859369
Coarctation of the aorta 33.53 11.95 17 57675 460 29894326
Chapped lips 33.16 11.95 17 57675 471 29894315
Drug level decreased 33.13 11.95 48 57644 5757 29889029
Blood prolactin increased 33.03 11.95 25 57667 1397 29893389
Plagiocephaly 32.88 11.95 15 57677 319 29894467
Ascites 32.85 11.95 14 57678 35907 29858879
Deep vein thrombosis 32.75 11.95 41 57651 60460 29834326
Hypotonia 31.97 11.95 52 57640 6896 29887890
Thinking abnormal 31.90 11.95 45 57647 5266 29889520
Depressed level of consciousness 31.87 11.95 152 57540 38070 29856716
Polydactyly 31.57 11.95 23 57669 1212 29893574
Rash erythematous 31.42 11.95 105 57587 22347 29872439
Abdominal pain upper 31.21 11.95 45 57647 62506 29832280
Illusion 30.99 11.95 19 57673 749 29894037
Chills 30.56 11.95 58 57634 72280 29822506
Septic shock 30.53 11.95 47 57645 63560 29831226
Hypernatraemia 30.44 11.95 53 57639 7431 29887355
Educational problem 30.38 11.95 14 57678 305 29894481
Paranoia 30.12 11.95 63 57629 10125 29884661
Pneumonitis 29.79 11.95 8 57684 27446 29867340
Myoclonic epilepsy 29.72 11.95 19 57673 807 29893979
Temperature regulation disorder 29.57 11.95 16 57676 496 29894290
Cytomegalovirus infection 29.56 11.95 5 57687 23669 29871117
Angina pectoris 29.50 11.95 10 57682 29508 29865278
Developmental regression 29.22 11.95 8 57684 32 29894754
Haemangioma congenital 29.17 11.95 16 57676 510 29894276
Convulsive threshold lowered 29.08 11.95 16 57676 513 29894273
Eye discharge 28.93 11.95 25 57667 1688 29893098
Distributive shock 28.70 11.95 17 57675 629 29894157
Speech disorder 28.61 11.95 108 57584 24404 29870382
Dysmetria 28.58 11.95 14 57678 351 29894435
Anticonvulsant drug level below therapeutic 28.55 11.95 17 57675 635 29894151
Drug level increased 28.55 11.95 89 57603 18265 29876521
Skin erosion 28.43 11.95 25 57667 1728 29893058
Strabismus 28.42 11.95 21 57671 1131 29893655
Personality disorder 28.37 11.95 21 57671 1134 29893652
Psychogenic seizure 28.18 11.95 13 57679 284 29894502
Derealisation 28.15 11.95 16 57676 547 29894239
Blood creatine phosphokinase increased 28.03 11.95 162 57530 43686 29851100
Movement disorder 27.93 11.95 60 57632 9823 29884963
Mucosal erosion 27.93 11.95 18 57674 775 29894011
Congenital genital malformation 27.90 11.95 7 57685 18 29894768
Peritonitis 27.86 11.95 4 57688 21371 29873415
Face oedema 27.77 11.95 65 57627 11269 29883517
Cerebral ventricle dilatation 27.75 11.95 18 57674 784 29894002
Suspiciousness 27.74 11.95 14 57678 375 29894411
Retinal pigment epitheliopathy 27.74 11.95 12 57680 224 29894562
Bicuspid aortic valve 27.74 11.95 12 57680 224 29894562
Catatonia 27.64 11.95 38 57654 4342 29890444
Suicide threat 27.63 11.95 7 57685 19 29894767
Rectal haemorrhage 26.93 11.95 17 57675 34922 29859864
Productive cough 26.87 11.95 12 57680 29941 29864845
Cleft lip 26.76 11.95 13 57679 320 29894466
Eosinophil percentage increased 26.74 11.95 15 57677 500 29894286
Gaze palsy 26.63 11.95 20 57672 1104 29893682
Syncope 26.40 11.95 80 57612 84823 29809963
Blood creatinine increased 26.38 11.95 89 57603 91286 29803500
Motor developmental delay 26.32 11.95 13 57679 332 29894454
Caesarean section 26.04 11.95 26 57666 2111 29892675
Epidermal necrosis 25.91 11.95 14 57678 433 29894353
Pilonidal cyst congenital 25.77 11.95 7 57685 27 29894759
Neonatal infection 25.53 11.95 12 57680 274 29894512
Cryptorchism 25.38 11.95 23 57669 1654 29893132
Musculoskeletal pain 25.33 11.95 14 57678 30926 29863860
Affect lability 25.19 11.95 32 57660 3386 29891400
Apnoea 25.04 11.95 44 57648 6214 29888572
Arthritis 24.85 11.95 8 57684 24393 29870393
Upper gastrointestinal haemorrhage 24.70 11.95 6 57686 22022 29872764
Lung disorder 24.68 11.95 15 57677 31454 29863332
Haematuria 24.67 11.95 30 57662 44804 29849982
Altered pitch perception 24.63 11.95 6 57686 13 29894773
Haematochezia 24.57 11.95 18 57674 34204 29860582
Anxiety 24.57 11.95 273 57419 89598 29805188
Cerebral infarction 24.56 11.95 10 57682 26363 29868423
Pancytopenia 24.44 11.95 83 57609 84969 29809817
Enanthema 24.42 11.95 13 57679 390 29894396
Atonic seizures 24.41 11.95 10 57682 162 29894624
Irregular sleep phase 24.36 11.95 8 57684 66 29894720
Rash morbilliform 24.35 11.95 27 57665 2475 29892311
Respiratory acidosis 24.35 11.95 35 57657 4167 29890619
Erythema 24.33 11.95 242 57450 77209 29817577
Hyperexplexia 23.98 11.95 7 57685 37 29894749
Disturbance in social behaviour 23.90 11.95 21 57671 1450 29893336
Intentional product use issue 23.87 11.95 21 57671 36419 29858367
Anticonvulsant drug level decreased 23.85 11.95 18 57674 1001 29893785
Hyperhomocysteinaemia 23.81 11.95 10 57682 173 29894613
Ear disorder 23.81 11.95 17 57675 868 29893918
Congenital melanocytic naevus 23.76 11.95 6 57686 16 29894770
Depersonalisation/derealisation disorder 23.75 11.95 14 57678 513 29894273
Epispadias 23.75 11.95 10 57682 174 29894612
Spina bifida 23.46 11.95 12 57680 331 29894455
Brain malformation 23.28 11.95 8 57684 77 29894709
Increased appetite 23.13 11.95 40 57652 5577 29889209
Osteonecrosis of jaw 23.10 11.95 4 57688 18614 29876172
Laryngomalacia 23.01 11.95 11 57681 261 29894525
Renal aplasia 22.93 11.95 15 57677 663 29894123
Transferrin increased 22.82 11.95 5 57687 5 29894781
Haemoptysis 22.77 11.95 16 57676 31062 29863724
Cardiac disorder 22.69 11.95 26 57666 39867 29854919
Hyperbilirubinaemia neonatal 22.69 11.95 15 57677 675 29894111
Pyramidal tract syndrome 22.67 11.95 10 57682 196 29894590
Congenital hand malformation 22.65 11.95 13 57679 453 29894333
Salivary hypersecretion 22.62 11.95 47 57645 7519 29887267
Confusional state 22.59 11.95 375 57317 134459 29760327
Lymphadenopathy 22.58 11.95 100 57592 24276 29870510
Encephalopathy 22.58 11.95 122 57570 32083 29862703
Congenital astigmatism 22.54 11.95 6 57686 21 29894765
Prostate cancer 22.45 11.95 9 57683 23948 29870838
Peripheral circulatory failure 22.39 11.95 10 57682 202 29894584
Postictal state 22.37 11.95 15 57677 691 29894095
Subgaleal haematoma 22.33 11.95 6 57686 22 29894764
Blood pressure increased 22.19 11.95 68 57624 71860 29822926
Insomnia 22.18 11.95 276 57416 93060 29801726
Language disorder 22.16 11.95 19 57673 1269 29893517
Delirium 22.11 11.95 144 57548 40487 29854299
Abulia 22.04 11.95 13 57679 477 29894309
Thrombocytopenia 22.00 11.95 164 57528 136880 29757906
Drooling 21.93 11.95 28 57664 2977 29891809
Madarosis 21.86 11.95 10 57682 214 29894572
Drug withdrawal convulsions 21.81 11.95 18 57674 1141 29893645
Anticonvulsant drug level above therapeutic 21.69 11.95 12 57680 389 29894397
Pulmonary oedema 21.58 11.95 32 57660 43943 29850843
Cerebral haemorrhage 21.48 11.95 19 57673 32868 29861918
Muscle twitching 21.34 11.95 48 57644 8107 29886679
International normalised ratio increased 21.30 11.95 37 57655 47702 29847084
Drug intolerance 21.22 11.95 34 57658 45257 29849529
Affective disorder 21.19 11.95 28 57664 3080 29891706
Distractibility 21.16 11.95 11 57681 314 29894472
Major depression 21.14 11.95 32 57660 3990 29890796
Mucosal exfoliation 21.02 11.95 4 57688 0 29894786
Skin malformation 21.02 11.95 4 57688 0 29894786
Influenza 20.89 11.95 32 57660 43366 29851420
Gout 20.88 11.95 4 57688 17311 29877475
Hepatic cirrhosis 20.83 11.95 3 57689 15996 29878790
Pulmonary fibrosis 20.65 11.95 3 57689 15887 29878899
Emotional disorder 20.62 11.95 36 57656 5058 29889728
Perivascular dermatitis 20.61 11.95 9 57683 172 29894614
Chest discomfort 20.51 11.95 35 57657 45445 29849341
Subacute cutaneous lupus erythematosus 20.50 11.95 14 57678 665 29894121
Psoriatic arthropathy 20.42 11.95 3 57689 15758 29879028
Tongue movement disturbance 20.40 11.95 7 57685 67 29894719
Neonatal tachypnoea 20.27 11.95 8 57684 117 29894669
Chronic kidney disease 20.10 11.95 26 57666 37812 29856974
Nasopharyngitis 20.09 11.95 53 57639 58796 29835990
Intellectual disability 20.06 11.95 15 57677 823 29893963
Muscle rigidity 20.05 11.95 54 57638 10207 29884579
Gambling disorder 19.91 11.95 21 57671 1819 29892967
Gait disturbance 19.91 11.95 226 57466 74551 29820235
Colitis 19.90 11.95 18 57674 30802 29863984
Developmental coordination disorder 19.78 11.95 6 57686 37 29894749
Tongue biting 19.76 11.95 14 57678 706 29894080
Cheilitis 19.68 11.95 23 57669 2233 29892553
Hypomagnesaemia 19.66 11.95 4 57688 16594 29878192
Teratogenicity 19.64 11.95 6 57686 38 29894748
Hallucination, visual 19.64 11.95 72 57620 16041 29878745
Snoring 19.64 11.95 26 57666 2865 29891921
Joint laxity 19.53 11.95 7 57685 77 29894709
Lennox-Gastaut syndrome 19.51 11.95 6 57686 39 29894747
Papule 19.49 11.95 27 57665 3106 29891680
Lung neoplasm malignant 19.33 11.95 3 57689 15129 29879657
Intraventricular haemorrhage neonatal 19.33 11.95 9 57683 201 29894585
Suspected suicide 19.31 11.95 27 57665 3134 29891652
Transverse presentation 19.29 11.95 7 57685 80 29894706
Parkinsonism 19.26 11.95 43 57649 7226 29887560
Scab 19.26 11.95 30 57662 3836 29890950
Lactic acidosis 19.25 11.95 19 57673 31194 29863592
Wrong product administered 19.16 11.95 33 57659 4585 29890201
Gangrene neonatal 19.16 11.95 9 57683 205 29894581
Ocular hyperaemia 19.11 11.95 49 57643 8994 29885792
Aplasia cutis congenita 19.07 11.95 8 57684 138 29894648
Blood potassium increased 19.01 11.95 4 57688 16209 29878577
Drug resistance 18.96 11.95 83 57609 20050 29874736
Pulmonary artery stenosis congenital 18.95 11.95 12 57680 501 29894285
Proteinuria 18.90 11.95 4 57688 16141 29878645
Diarrhoea neonatal 18.90 11.95 5 57687 17 29894769
Intelligence test abnormal 18.90 11.95 5 57687 17 29894769
Potter's syndrome 18.90 11.95 5 57687 17 29894769
Congenital central nervous system anomaly 18.81 11.95 11 57681 397 29894389
Dehydration 18.80 11.95 150 57542 123389 29771397
Skin degenerative disorder 18.68 11.95 5 57687 18 29894768
Congenital myopia 18.68 11.95 5 57687 18 29894768
Melaena 18.60 11.95 21 57671 32416 29862370
Bone marrow failure 18.52 11.95 18 57674 29767 29865019
Anaphylactic reaction 18.48 11.95 16 57676 27966 29866820
Congenital eyelid malformation 18.43 11.95 6 57686 48 29894738
Blood urea increased 18.34 11.95 20 57672 31361 29863425
Mental impairment 18.31 11.95 49 57643 9228 29885558
Clostridium difficile infection 18.29 11.95 4 57688 15779 29879007
Aphasia 18.20 11.95 80 57612 19359 29875427
Full blood count decreased 18.18 11.95 4 57688 15713 29879073
Oral disorder 18.15 11.95 30 57662 4032 29890754
Colitis ulcerative 18.13 11.95 3 57689 14431 29880355
Hypoglycaemia 18.11 11.95 45 57647 50936 29843850
Akathisia 18.03 11.95 37 57655 5867 29888919
Differential white blood cell count abnormal 18.02 11.95 17 57675 1287 29893499
Psoriasis 18.01 11.95 34 57658 42472 29852314
Coordination abnormal 18.01 11.95 42 57650 7263 29887523
Weight decrease neonatal 18.00 11.95 10 57682 327 29894459
Feeling jittery 17.98 11.95 29 57663 3819 29890967
Compulsive shopping 17.86 11.95 11 57681 437 29894349
Foetal distress syndrome 17.83 11.95 15 57677 976 29893810
Hypertonia 17.76 11.95 31 57661 4354 29890432
Thrombosis 17.70 11.95 34 57658 42197 29852589
Single umbilical artery 17.63 11.95 9 57683 247 29894539
Cardio-respiratory arrest 17.48 11.95 178 57514 57128 29837658
Myalgia 17.47 11.95 82 57610 76585 29818201
Arthropod sting 17.40 11.95 9 57683 254 29894532
Blood pressure fluctuation 17.36 11.95 6 57686 17497 29877289
Treatment noncompliance 17.25 11.95 95 57597 25158 29869628
Skull malformation 17.20 11.95 10 57682 357 29894429
Impulsive behaviour 17.08 11.95 20 57672 1945 29892841
Skin exfoliation 17.08 11.95 89 57603 23083 29871703
Myocardial ischaemia 17.07 11.95 6 57686 17311 29877475
Cataplexy 17.05 11.95 10 57682 363 29894423
Wrong schedule 17.05 11.95 7 57685 114 29894672
Congenital genital malformation male 16.98 11.95 4 57688 7 29894779
Tongue eruption 16.98 11.95 4 57688 7 29894779
Hyperglycaemia 16.90 11.95 26 57666 35174 29859612
Disorientation 16.87 11.95 111 57581 31307 29863479
Fluid retention 16.87 11.95 14 57678 24984 29869802
Fallot's tetralogy 16.73 11.95 8 57684 190 29894596
Crystal urine present 16.72 11.95 9 57683 276 29894510
Feeling drunk 16.68 11.95 18 57674 1601 29893185
Product name confusion 16.66 11.95 6 57686 67 29894719
Acute coronary syndrome 16.65 11.95 3 57689 13570 29881216
Sinusitis 16.62 11.95 24 57668 33321 29861465
Lip oedema 16.57 11.95 21 57671 2216 29892570
Congenital inguinal hernia 16.57 11.95 7 57685 123 29894663
Transaminases increased 16.54 11.95 89 57603 23368 29871418
Neoplasm progression 16.51 11.95 7 57685 18016 29876770
Blood glucose increased 16.37 11.95 62 57630 61468 29833318
Visuospatial deficit 16.32 11.95 4 57688 9 29894777
Double outlet right ventricle 16.26 11.95 7 57685 129 29894657
Cerebral atrophy 16.24 11.95 30 57662 4403 29890383
Renal disorder 16.17 11.95 13 57679 23571 29871215
Mucosal inflammation 16.15 11.95 21 57671 30473 29864313
Mouth ulceration 16.09 11.95 51 57641 10558 29884228
Cerebellar syndrome 16.07 11.95 20 57672 2072 29892714
Congenital scoliosis 16.07 11.95 5 57687 34 29894752
Obsessive thoughts 16.03 11.95 12 57680 659 29894127
Postmature baby 16.03 11.95 4 57688 10 29894776
Deja vu 16.03 11.95 4 57688 10 29894776
Bacteraemia 16.02 11.95 5 57687 15555 29879231
Eyelid oedema 15.86 11.95 32 57660 5013 29889773
Anal atresia 15.85 11.95 9 57683 307 29894479
Vesicoureteric reflux 15.83 11.95 7 57685 138 29894648
Genital erosion 15.83 11.95 8 57684 215 29894571
Product dispensing error 15.78 11.95 35 57657 5854 29888932
Trichiasis 15.76 11.95 3 57689 0 29894786
Metabolic myopathy 15.76 11.95 3 57689 0 29894786
Rubella 15.76 11.95 3 57689 0 29894786
Bundle branch block right 15.76 11.95 39 57653 7003 29887783
Congenital diaphragmatic hernia 15.73 11.95 8 57684 218 29894568
Altered state of consciousness 15.72 11.95 78 57614 19841 29874945
Pulmonary hypoplasia 15.72 11.95 10 57682 421 29894365
Persecutory delusion 15.71 11.95 20 57672 2120 29892666
Skin turgor decreased 15.70 11.95 10 57682 422 29894364
Wheezing 15.68 11.95 22 57670 30916 29863870
Nasal disorder 15.68 11.95 15 57677 1156 29893630
Euphoric mood 15.68 11.95 29 57663 4261 29890525
Hypoxia 15.66 11.95 44 57648 47810 29846976
Diverticulitis 15.63 11.95 7 57685 17438 29877348
Pulmonary valve stenosis congenital 15.60 11.95 7 57685 143 29894643
Suicidal behaviour 15.56 11.95 16 57676 1346 29893440
Product use in unapproved indication 15.54 11.95 81 57611 73612 29821174
Exposure via ingestion 15.50 11.95 22 57670 2589 29892197
Congenital cerebral cyst 15.50 11.95 4 57688 12 29894774
Congenital muscle absence 15.47 11.95 5 57687 39 29894747
Congenital vas deferens absence 15.47 11.95 5 57687 39 29894747
Chordee 15.37 11.95 6 57686 85 29894701
Drop attacks 15.36 11.95 11 57681 564 29894222
Delusional perception 15.34 11.95 7 57685 149 29894637
Cellulitis 15.32 11.95 43 57649 46741 29848045
Pneumocystis jirovecii pneumonia 15.13 11.95 7 57685 17113 29877673
Heart rate decreased 15.12 11.95 11 57681 20983 29873803
Schizophrenia 15.12 11.95 45 57647 9003 29885783
Hypermobility syndrome 15.09 11.95 8 57684 238 29894548
Automatism 15.06 11.95 6 57686 90 29894696
Peripheral artery thrombosis 15.05 11.95 20 57672 2212 29892574
Bone pain 15.02 11.95 9 57683 19017 29875769
Urinary tract infection 14.95 11.95 82 57610 73577 29821209
Extrapyramidal disorder 14.95 11.95 50 57642 10643 29884143
Excessive eye blinking 14.93 11.95 8 57684 243 29894543
Localised infection 14.91 11.95 4 57688 13733 29881053
Hypothermia neonatal 14.88 11.95 6 57686 93 29894693
Hypercalcaemia 14.82 11.95 3 57689 12492 29882294
Moaning 14.78 11.95 12 57680 743 29894043
Heart disease congenital 14.77 11.95 15 57677 1243 29893543
COVID-19 14.76 11.95 8 57684 17870 29876916
Exomphalos 14.76 11.95 7 57685 163 29894623
Neoplasm malignant 14.67 11.95 8 57684 17806 29876980
Hypothermia 14.52 11.95 46 57646 9521 29885265
Angina unstable 14.51 11.95 3 57689 12307 29882479
Oculomucocutaneous syndrome 14.46 11.95 7 57685 171 29894615
Conversion disorder 14.43 11.95 9 57683 366 29894420
Nephritis allergic 14.34 11.95 9 57683 370 29894416
Caudal regression syndrome 14.29 11.95 5 57687 51 29894735
Erythema annulare 14.23 11.95 4 57688 18 29894768
Circadian rhythm sleep disorder 14.23 11.95 9 57683 375 29894411
Transient tachypnoea of the newborn 14.20 11.95 7 57685 178 29894608
Multiple congenital abnormalities 14.17 11.95 10 57682 501 29894285
Lethargy 14.15 11.95 127 57565 39392 29855394
Dysphoria 14.10 11.95 19 57673 2129 29892657
Hyperreflexia 14.10 11.95 22 57670 2817 29891969
Rash macular 14.07 11.95 48 57644 10319 29884467
Hyperphagia 14.03 11.95 15 57677 1320 29893466
Candida infection 14.02 11.95 6 57686 15356 29879430
Epidermolysis 13.96 11.95 8 57684 278 29894508
Metastases to liver 13.93 11.95 3 57689 11962 29882824
Blunted affect 13.91 11.95 8 57684 280 29894506
Dacryostenosis congenital 13.89 11.95 4 57688 20 29894766
Mental disorder 13.87 11.95 57 57635 13392 29881394
Visual field defect 13.78 11.95 28 57664 4408 29890378
Symblepharon 13.77 11.95 6 57686 114 29894672
Parasomnia 13.75 11.95 8 57684 286 29894500
Constipation 13.74 11.95 145 57547 112761 29782025
Hypokalaemia 13.73 11.95 50 57642 50142 29844644
Congenital knee deformity 13.71 11.95 5 57687 58 29894728
Grimacing 13.70 11.95 8 57684 288 29894498
Therapeutic product effective for unapproved indication 13.69 11.95 3 57689 3 29894783
Encephalocele 13.69 11.95 3 57689 3 29894783
Judgement impaired 13.68 11.95 11 57681 672 29894114
Psychotic symptom 13.64 11.95 14 57678 1175 29893611
Blood pressure systolic increased 13.63 11.95 6 57686 15104 29879682
Sweat gland disorder 13.63 11.95 6 57686 117 29894669
Terminal insomnia 13.59 11.95 9 57683 406 29894380
Oral mucosal erythema 13.57 11.95 9 57683 407 29894379
Pleurothotonus 13.50 11.95 13 57679 1010 29893776
Somnolence neonatal 13.42 11.95 4 57688 23 29894763
Low set ears 13.40 11.95 9 57683 416 29894370
Pollakiuria 13.34 11.95 8 57684 16898 29877888
Clostridium difficile colitis 13.33 11.95 4 57688 12764 29882022
Conjunctival irritation 13.31 11.95 6 57686 124 29894662
Conjunctival scar 13.20 11.95 5 57687 65 29894721
Respiratory arrest 13.15 11.95 99 57593 29159 29865627
Muscle spasticity 12.98 11.95 30 57662 5158 29889628
Asterixis 12.97 11.95 14 57678 1245 29893541
Unevaluable event 12.97 11.95 26 57666 31759 29863027
Torticollis 12.95 11.95 13 57679 1062 29893724
Economic problem 12.95 11.95 15 57677 1442 29893344
Limited symptom panic attack 12.93 11.95 5 57687 69 29894717
Neurological decompensation 12.92 11.95 19 57673 2309 29892477
Abortion induced 12.88 11.95 6 57686 134 29894652
Cataract congenital 12.87 11.95 5 57687 70 29894716
Mood swings 12.81 11.95 38 57654 7588 29887198
Congenital aortic atresia 12.75 11.95 4 57688 28 29894758
Clinodactyly 12.72 11.95 6 57686 138 29894648
Full blood count abnormal 12.70 11.95 13 57679 1087 29893699
External auditory canal atresia 12.68 11.95 6 57686 139 29894647
Cataract 12.66 11.95 14 57678 21821 29872965
Wrist deformity 12.63 11.95 8 57684 334 29894452
Muscle tone disorder 12.61 11.95 5 57687 74 29894712
Oesophagitis 12.61 11.95 3 57689 11168 29883618
Rash papular 12.60 11.95 41 57651 8604 29886182
Feeling of despair 12.51 11.95 12 57680 928 29893858
Aortic valve atresia 12.48 11.95 3 57689 6 29894780
Drug therapy enhancement 12.48 11.95 3 57689 6 29894780
Congenital spinal cord anomaly 12.48 11.95 3 57689 6 29894780
Assisted delivery 12.48 11.95 3 57689 6 29894780
Agitated depression 12.46 11.95 7 57685 234 29894552
Pulmonary hypertension 12.43 11.95 11 57681 19025 29875761
Congenital pulmonary valve atresia 12.37 11.95 5 57687 78 29894708
Spine malformation 12.30 11.95 6 57686 149 29894637
Prominent epicanthal folds 12.27 11.95 6 57686 150 29894636
Hospitalisation 12.22 11.95 44 57648 44275 29850511
Dyspepsia 12.21 11.95 25 57667 30304 29864482
Neurofibromatosis 12.16 11.95 3 57689 7 29894779
Gastric ulcer 12.15 11.95 7 57685 15114 29879672
Enuresis 12.12 11.95 16 57676 1758 29893028
Prostatic specific antigen increased 12.11 11.95 4 57688 12000 29882786
Delusion of grandeur 12.10 11.95 8 57684 360 29894426
Essential tremor 12.08 11.95 11 57681 796 29893990
Pulmonary valve stenosis 12.08 11.95 8 57684 361 29894425
Congenital tricuspid valve atresia 12.04 11.95 5 57687 84 29894702
Learning disability 12.02 11.95 6 57686 157 29894629
Loss of employment 11.97 11.95 9 57683 498 29894288

Pharmacologic Action:

SourceCodeDescription
ATC N03AX09 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
MeSH PA D000927 Anticonvulsants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D011619 Psychotropic Drugs
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35477 antimanics
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:60798 excitatory amino acid receptor antagonists
CHEBI has role CHEBI:76779 prolyl oligopeptidase (ec 3.4.21.26) inhibitor
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Lennox-Gastaut syndrome indication 230418006
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Pancytopenia contraindication 127034005 DOID:12450
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.3 Basic
pKa2 0.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER IC50 4.02 CHEMBL CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 4.21 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.77 CHEMBL CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER IC50 5 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 3.84 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel IC50 4.74 WOMBAT-PK
Sodium channel protein type X alpha subunit Unclassified IC50 4.60 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.51 CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel IC50 4.46 CHEMBL

External reference:

IDSource
D00354 KEGG_DRUG
4020896 VANDF
C0701238 UMLSCUI
CHEBI:6367 CHEBI
CHEMBL741 ChEMBL_ID
D000077213 MESH_DESCRIPTOR_UI
DB00555 DRUGBANK_ID
3878 PUBCHEM_CID
2622 IUPHAR_LIGAND_ID
5638 INN_ID
U3H27498KS UNII
196502 RXNORM
1506 MMSL
4957 MMSL
69610 MMSL
d03809 MMSL
003988 NDDF
387562000 SNOMEDCT_US
96195007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1526 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1527 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1528 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1529 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9939 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9940 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9941 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9942 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0761 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL NDA 29 sections
LAMICTALODT HUMAN PRESCRIPTION DRUG LABEL 1 0173-0772 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA 28 sections
LAMICTALODT HUMAN PRESCRIPTION DRUG LABEL 1 0173-0774 TABLET, ORALLY DISINTEGRATING 50 mg ORAL NDA 28 sections
LAMICTALODT HUMAN PRESCRIPTION DRUG LABEL 1 0173-0776 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA 28 sections
LAMICTALODT HUMAN PRESCRIPTION DRUG LABEL 1 0173-0777 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA 28 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0781 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL NDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0228-1410 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0228-1422 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0228-1435 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0228-1453 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0228-1580 TABLET, FILM COATED, EXTENDED RELEASE 300 mg ORAL ANDA 29 sections