lamotrigine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1540 84057-84-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lamictal
  • lamotrigine
  • lamitrin
  • lamotrigin
  • BW 430C
A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
  • Molecular weight: 256.09
  • Formula: C9H7Cl2N5
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 90.71
  • ALOGS: -2.72
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.17 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 27.89 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97.60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 27, 1994 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2268.95 10.62 2012 116795 115862 50370455
Drug reaction with eosinophilia and systemic symptoms 1744.98 10.62 988 117819 27436 50458881
Completed suicide 1277.20 10.62 1559 117248 130330 50355987
Stevens-Johnson syndrome 1254.08 10.62 726 118081 21026 50465291
Exposure during pregnancy 1146.34 10.62 1415 117392 119600 50366717
Intentional overdose 945.86 10.62 935 117872 61569 50424748
Toxicity to various agents 862.15 10.62 1678 117129 210821 50275496
Product substitution issue 783.08 10.62 459 118348 13598 50472719
Generalised tonic-clonic seizure 693.55 10.62 540 118267 25770 50460547
Abortion spontaneous 594.98 10.62 605 118202 41167 50445150
Toxic epidermal necrolysis 540.54 10.62 425 118382 20567 50465750
Epilepsy 530.40 10.62 425 118382 21142 50465175
Drug interaction 525.93 10.62 1327 117480 198294 50288023
Suicide attempt 513.22 10.62 620 118187 51112 50435205
Intentional self-injury 445.85 10.62 396 118411 22716 50463601
Foetal exposure during pregnancy 411.03 10.62 408 118399 26951 50459366
Overdose 388.03 10.62 775 118032 98952 50387365
Suicidal ideation 341.20 10.62 527 118280 54858 50431459
Somnolence 334.77 10.62 958 117849 154027 50332290
Rheumatoid arthritis 329.98 10.62 43 118764 202507 50283810
Nystagmus 318.64 10.62 185 118622 5376 50480941
Status epilepticus 316.47 10.62 258 118549 13148 50473169
Joint swelling 316.12 10.62 92 118715 245194 50241123
Arthralgia 297.69 10.62 356 118451 438346 50047971
Pain 293.83 10.62 573 118234 578330 49907987
Contraindicated product administered 287.95 10.62 15 118792 148943 50337374
Diarrhoea 286.27 10.62 597 118210 587879 49898438
Aggression 280.96 10.62 295 118512 20821 50465496
Petit mal epilepsy 279.27 10.62 142 118665 3147 50483170
Infusion related reaction 273.72 10.62 37 118770 169520 50316797
Rash maculo-papular 273.41 10.62 325 118482 26316 50460001
Lymphadenopathy 271.17 10.62 363 118444 33136 50453181
Dyspnoea 270.08 10.62 551 118256 547057 49939260
Tremor 259.43 10.62 722 118085 114181 50372136
Drug eruption 258.95 10.62 298 118509 23308 50463009
Agitation 258.73 10.62 456 118351 52928 50433389
Arthropathy 258.38 10.62 33 118774 157873 50328444
Synovitis 258.05 10.62 7 118800 123858 50362459
Mania 257.49 10.62 210 118597 10706 50475611
Ataxia 249.64 10.62 228 118579 13558 50472759
Pneumonia 236.91 10.62 326 118481 378075 50108242
Peripheral swelling 236.18 10.62 94 118713 205842 50280475
Focal dyscognitive seizures 220.52 10.62 114 118693 2618 50483699
Hand deformity 219.38 10.62 3 118804 100196 50386121
Oral mucosa erosion 214.51 10.62 84 118723 971 50485346
Serotonin syndrome 214.24 10.62 277 118530 24436 50461881
Diplopia 209.33 10.62 242 118565 19018 50467299
Irritability 201.53 10.62 289 118518 28137 50458180
Abdominal discomfort 200.00 10.62 151 118656 231490 50254827
Swelling 196.26 10.62 114 118693 200758 50285559
Nasopharyngitis 184.94 10.62 112 118695 192815 50293502
Sudden unexplained death in epilepsy 182.31 10.62 54 118753 239 50486078
Depression 178.24 10.62 815 117992 164608 50321709
Rash 177.58 10.62 1684 117123 435787 50050530
Disturbance in attention 173.03 10.62 283 118524 30903 50455414
Partial seizures 171.36 10.62 119 118688 4746 50481571
Atrial septal defect 171.01 10.62 132 118675 6209 50480108
Pain in extremity 170.64 10.62 235 118572 272630 50213687
Coma 166.12 10.62 394 118413 56485 50429832
Lip erosion 161.89 10.62 64 118743 760 50485557
Abortion induced 160.37 10.62 150 118657 9194 50477123
Drug intolerance 157.79 10.62 169 118638 218935 50267382
Erythema multiforme 156.71 10.62 146 118661 8904 50477413
Abnormal behaviour 152.94 10.62 209 118598 19449 50466868
Glossodynia 151.19 10.62 42 118765 115527 50370790
Anticonvulsant drug level decreased 149.72 10.62 67 118740 1104 50485213
Anaemia 149.37 10.62 226 118581 252230 50234087
Poisoning 146.66 10.62 163 118644 12266 50474051
Systemic lupus erythematosus 145.76 10.62 74 118733 140548 50345769
Alopecia 145.32 10.62 219 118588 244828 50241489
Anxiety 143.48 10.62 807 118000 176799 50309518
Multiple-drug resistance 140.60 10.62 91 118716 3223 50483094
Psychotic disorder 139.08 10.62 211 118596 21601 50464716
Ventricular septal defect 138.02 10.62 97 118710 3944 50482373
Conjunctival hyperaemia 137.45 10.62 76 118731 2006 50484311
Maternal exposure during breast feeding 137.19 10.62 89 118718 3165 50483152
Hyperreflexia 136.84 10.62 106 118701 5012 50481305
Fatigue 136.76 10.62 1038 117769 706563 49779754
Myoclonus 136.19 10.62 169 118638 14301 50472016
Selective eating disorder 135.20 10.62 72 118735 1760 50484557
Infection 134.11 10.62 125 118682 172829 50313488
Bipolar disorder 132.69 10.62 117 118690 6640 50479677
Myoclonic epilepsy 131.78 10.62 58 118749 917 50485400
Lower respiratory tract infection 131.42 10.62 31 118776 95170 50391147
Clonus 128.34 10.62 94 118713 4081 50482236
Wound 126.68 10.62 45 118762 105749 50380568
Discomfort 126.57 10.62 48 118759 108332 50377985
Hyperthermia 125.31 10.62 120 118687 7576 50478741
Sinusitis 124.48 10.62 130 118677 170428 50315889
Aura 122.00 10.62 55 118752 923 50485394
Extrapyramidal disorder 121.41 10.62 144 118663 11626 50474691
Haemophagocytic lymphohistiocytosis 120.91 10.62 124 118683 8509 50477808
Obsessive-compulsive disorder 118.34 10.62 82 118725 3258 50483059
Rash morbilliform 117.93 10.62 77 118730 2769 50483548
Disease progression 116.11 10.62 40 118767 95826 50390491
Tardive dyskinesia 115.69 10.62 112 118695 7167 50479150
Back pain 115.26 10.62 213 118594 219817 50266500
Atrial fibrillation 114.00 10.62 48 118759 101697 50384620
Cough 111.56 10.62 251 118556 241013 50245304
Pleurothotonus 109.96 10.62 56 118751 1245 50485072
Drug level increased 109.78 10.62 177 118630 19091 50467226
Pregnancy 109.06 10.62 225 118582 29352 50456965
Suicidal behaviour 108.75 10.62 68 118739 2266 50484051
Face oedema 108.72 10.62 169 118638 17670 50468647
Anticonvulsant drug level increased 106.69 10.62 56 118751 1328 50484989
Electrocardiogram QRS complex prolonged 105.87 10.62 93 118714 5251 50481066
Cross sensitivity reaction 103.60 10.62 62 118745 1907 50484410
Drug level decreased 102.85 10.62 100 118707 6433 50479884
Muscle rigidity 102.61 10.62 121 118686 9708 50476609
Meningitis aseptic 102.40 10.62 82 118725 4070 50482247
Toxic skin eruption 102.04 10.62 129 118678 11122 50475195
Exposure via breast milk 101.52 10.62 57 118750 1551 50484766
Depressed level of consciousness 100.35 10.62 309 118498 51644 50434673
Maternal drugs affecting foetus 99.87 10.62 88 118719 4989 50481328
Cardiac failure congestive 97.47 10.62 38 118769 84344 50401973
Cognitive disorder 97.21 10.62 275 118532 43848 50442469
Neuroleptic malignant syndrome 95.26 10.62 124 118683 11006 50475311
Death 94.98 10.62 417 118390 324962 50161355
Therapeutic product effect decreased 94.49 10.62 108 118699 135942 50350375
Malignant neoplasm progression 94.38 10.62 22 118785 68102 50418215
Anticonvulsant drug level above therapeutic 94.37 10.62 38 118769 475 50485842
Eosinophilia 92.47 10.62 161 118646 18491 50467826
Febrile neutropenia 90.33 10.62 59 118748 97608 50388709
Cardio-respiratory arrest 89.14 10.62 304 118503 53588 50432729
Anger 88.91 10.62 121 118686 11212 50475105
Caesarean section 88.19 10.62 143 118664 15496 50470821
Stillbirth 87.93 10.62 88 118719 5864 50480453
Chest pain 87.57 10.62 177 118630 176705 50309612
Depressed mood 86.94 10.62 224 118583 33799 50452518
Camptocormia 86.93 10.62 31 118776 270 50486047
Infarction 86.84 10.62 59 118748 2269 50484048
Impaired healing 86.45 10.62 28 118779 69758 50416559
Gastrointestinal haemorrhage 86.38 10.62 32 118775 73289 50413028
Electroencephalogram abnormal 86.08 10.62 69 118738 3430 50482887
Pericarditis 85.17 10.62 39 118768 78650 50407667
Hypogammaglobulinaemia 83.72 10.62 84 118723 5615 50480702
Suspected suicide 82.47 10.62 81 118726 5276 50481041
Vertigo 81.92 10.62 288 118519 51544 50434773
Pyrexia 81.70 10.62 1299 117508 378904 50107413
Delusion 81.64 10.62 112 118695 10457 50475860
Sedation 80.78 10.62 204 118603 30406 50455911
Hypomania 80.56 10.62 74 118733 4431 50481886
Hypertension 80.53 10.62 242 118565 210961 50275356
Bipolar I disorder 80.39 10.62 48 118759 1470 50484847
Mobility decreased 79.96 10.62 44 118763 79904 50406413
Cardiac arrest 79.69 10.62 398 118409 83253 50403064
Acute kidney injury 79.50 10.62 272 118535 227786 50258531
Mood altered 79.22 10.62 122 118685 12651 50473666
Neuropathy peripheral 78.46 10.62 67 118740 96690 50389627
Intentional product use issue 77.41 10.62 42 118765 76876 50409441
Unresponsive to stimuli 76.65 10.62 200 118607 30409 50455908
Blood pressure increased 75.94 10.62 122 118685 133010 50353307
Electrocardiogram QT prolonged 75.80 10.62 281 118526 51605 50434712
Irritable bowel syndrome 74.53 10.62 15 118792 51426 50434891
Hallucination, auditory 74.45 10.62 108 118699 10620 50475697
Arthritis 74.12 10.62 57 118750 86664 50399653
Muscle injury 74.05 10.62 3 118804 37108 50449209
Dyskinesia 73.86 10.62 186 118621 27675 50458642
Folliculitis 72.56 10.62 5 118802 39220 50447097
Dizziness 72.34 10.62 1178 117629 345191 50141126
Rash papular 72.09 10.62 116 118691 12488 50473829
Therapeutic response unexpected 72.00 10.62 132 118675 15783 50470534
Bronchitis 71.96 10.62 83 118724 104076 50382241
Product use issue 71.92 10.62 152 118655 149323 50336994
Behaviour disorder 71.83 10.62 53 118754 2327 50483990
Akathisia 70.92 10.62 92 118715 8137 50478180
Hypersensitivity 70.73 10.62 263 118544 214898 50271419
Musculoskeletal pain 70.34 10.62 41 118766 72136 50414181
Hyperkalaemia 69.72 10.62 14 118793 48075 50438242
Haemoglobin decreased 69.38 10.62 120 118687 127096 50359221
Gastrointestinal disorder 68.86 10.62 72 118735 94384 50391933
Respiratory arrest 67.03 10.62 188 118619 29821 50456496
Psychomotor retardation 66.74 10.62 59 118748 3359 50482958
Rash macular 65.67 10.62 142 118665 19135 50467182
Mood swings 64.34 10.62 126 118681 15828 50470489
Treatment failure 63.69 10.62 143 118664 137494 50348823
Drug abuse 63.68 10.62 294 118513 59552 50426765
Psychomotor hyperactivity 63.62 10.62 93 118714 9208 50477109
Small for dates baby 63.50 10.62 58 118749 3447 50482870
Talipes 62.89 10.62 40 118767 1374 50484943
Atonic seizures 62.60 10.62 30 118777 582 50485735
Inappropriate antidiuretic hormone secretion 61.99 10.62 111 118696 13032 50473285
Blepharospasm 61.82 10.62 53 118754 2895 50483422
Chronic obstructive pulmonary disease 61.80 10.62 24 118783 53411 50432906
Epileptic aura 61.79 10.62 17 118790 54 50486263
Herpes zoster 61.16 10.62 46 118761 70740 50415577
Injection site erythema 60.61 10.62 52 118755 74884 50411433
Inappropriate affect 60.35 10.62 32 118775 775 50485542
Enanthema 59.28 10.62 25 118782 354 50485963
Cerebellar syndrome 58.45 10.62 54 118753 3257 50483060
Trichiasis 58.35 10.62 16 118791 50 50486267
Dysmorphism 58.19 10.62 45 118762 2122 50484195
Tic 58.07 10.62 36 118771 1181 50485136
Affective disorder 57.80 10.62 66 118741 5115 50481202
Cardiac failure 57.66 10.62 56 118751 75984 50410333
Cerebrovascular accident 57.60 10.62 83 118724 94597 50391720
Muscle twitching 57.60 10.62 118 118689 15313 50471004
Drug clearance increased 57.44 10.62 17 118790 75 50486242
Patent ductus arteriosus 57.39 10.62 57 118750 3763 50482554
Restlessness 56.51 10.62 158 118649 25015 50461302
Cheilitis 56.34 10.62 55 118752 3555 50482762
Osteoarthritis 56.23 10.62 47 118760 68559 50417758
Dyspnoea exertional 56.05 10.62 25 118782 51208 50435109
General physical health deterioration 55.85 10.62 161 118646 142273 50344044
Maternal exposure during pregnancy 55.74 10.62 597 118210 159181 50327136
Sleep disorder due to general medical condition, insomnia type 55.39 10.62 5 118802 31442 50454875
Pregnancy on oral contraceptive 55.22 10.62 32 118775 926 50485391
Myocardial infarction 55.19 10.62 77 118730 88950 50397367
Balance disorder 55.07 10.62 318 118489 70272 50416045
Speech disorder 54.85 10.62 196 118611 35352 50450965
Rash erythematous 54.50 10.62 193 118614 34659 50451658
Asthenia 54.41 10.62 483 118324 318559 50167758
Tachycardia 53.91 10.62 410 118397 99353 50386964
Coordination abnormal 53.87 10.62 97 118710 11437 50474880
Neovascularisation 53.56 10.62 32 118775 981 50485336
Mental impairment 53.36 10.62 99 118708 11945 50474372
Mental disorder 53.33 10.62 142 118665 21849 50464468
Sopor 52.98 10.62 133 118674 19746 50466571
Dystonia 52.79 10.62 98 118709 11828 50474489
Memory impairment 52.75 10.62 343 118464 79017 50407300
Congenital choroid plexus cyst 52.72 10.62 22 118785 303 50486014
Partial seizures with secondary generalisation 52.65 10.62 22 118785 304 50486013
Live birth 52.65 10.62 118 118689 16290 50470027
Oculogyric crisis 52.61 10.62 36 118771 1401 50484916
Oculomucocutaneous syndrome 52.57 10.62 17 118790 106 50486211
Plasma cell myeloma 52.52 10.62 6 118801 31316 50455001
Foetal anticonvulsant syndrome 52.39 10.62 26 118781 546 50485771
Fluid retention 51.92 10.62 27 118780 50622 50435695
Hallucination 51.71 10.62 232 118575 46425 50439892
Injection site pain 51.64 10.62 115 118692 110909 50375408
Coronary artery disease 51.63 10.62 5 118802 29721 50456596
Therapeutic response changed 51.16 10.62 29 118778 804 50485513
Altered state of consciousness 50.65 10.62 139 118668 21771 50464546
Skin degenerative disorder 50.57 10.62 10 118797 0 50486317
Pain in jaw 50.16 10.62 14 118793 38414 50447903
Poisoning deliberate 49.67 10.62 76 118731 7836 50478481
Papule 49.57 10.62 56 118751 4289 50482028
Diverticulitis 49.50 10.62 9 118798 33173 50453144
Human herpesvirus 6 infection 48.93 10.62 44 118763 2562 50483755
Blood pressure systolic increased 48.01 10.62 12 118795 35437 50450880
Thinking abnormal 47.96 10.62 83 118724 9484 50476833
Musculoskeletal stiffness 47.65 10.62 149 118658 128332 50357985
Impulsive behaviour 47.49 10.62 34 118773 1424 50484893
C-reactive protein abnormal 47.46 10.62 5 118802 27804 50458513
Sepsis 47.32 10.62 157 118650 132768 50353549
Loss of consciousness 47.27 10.62 412 118395 103941 50382376
Asthma 47.13 10.62 86 118721 89251 50397066
Intellectual disability 47.04 10.62 27 118780 767 50485550
Hypertonia 46.69 10.62 52 118755 3921 50482396
Constipation 46.54 10.62 251 118556 185457 50300860
Rash vesicular 46.45 10.62 49 118758 3474 50482843
Hypotonia neonatal 46.33 10.62 29 118778 968 50485349
Oral disorder 45.97 10.62 73 118734 7771 50478546
Hip arthroplasty 45.94 10.62 8 118799 30421 50455896
Mucosal disorder 45.83 10.62 37 118770 1858 50484459
Lip ulceration 45.26 10.62 36 118771 1769 50484548
Premature baby 45.07 10.62 119 118688 18218 50468099
Hydrops foetalis 44.94 10.62 20 118787 325 50485992
Parkinsonism 44.68 10.62 77 118730 8770 50477547
Dehydration 44.60 10.62 195 118612 152254 50334063
Abdominal pain 44.60 10.62 348 118459 235880 50250437
Productive cough 44.55 10.62 35 118772 52659 50433658
Persecutory delusion 44.23 10.62 40 118767 2347 50483970
Developmental hip dysplasia 44.11 10.62 31 118776 1260 50485057
Lactic acidosis 43.82 10.62 12 118795 33343 50452974
Renal failure 43.67 10.62 118 118689 106515 50379802
Eyelid erosion 43.64 10.62 12 118795 38 50486279
Nausea 43.64 10.62 1293 117514 704105 49782212
Temporal lobe epilepsy 43.60 10.62 20 118787 350 50485967
Conjunctival abrasion 43.59 10.62 11 118796 22 50486295
Logorrhoea 43.17 10.62 39 118768 2285 50484032
Malaise 42.97 10.62 543 118264 334989 50151328
Mydriasis 42.94 10.62 84 118723 10543 50475774
Drug withdrawal convulsions 42.80 10.62 31 118776 1322 50484995
Cyanosis neonatal 42.61 10.62 18 118789 256 50486061
Unintended pregnancy 42.16 10.62 55 118752 4891 50481426
Deep vein thrombosis 41.94 10.62 67 118740 73237 50413080
Autism spectrum disorder 41.90 10.62 24 118783 679 50485638
Simple partial seizures 41.79 10.62 22 118785 525 50485792
Gestational diabetes 41.73 10.62 68 118739 7397 50478920
Knee arthroplasty 41.62 10.62 16 118791 35830 50450487
Hepatic enzyme increased 41.24 10.62 174 118633 137206 50349111
Lymphocyte morphology abnormal 41.18 10.62 20 118787 400 50485917
Apathy 41.18 10.62 68 118739 7480 50478837
Photophobia 41.15 10.62 101 118706 14786 50471531
Microcephaly 41.14 10.62 25 118782 791 50485526
Retrognathia 41.00 10.62 20 118787 404 50485913
Conjunctivitis 40.93 10.62 106 118701 16039 50470278
Coarctation of the aorta 40.83 10.62 22 118785 551 50485766
Euphoric mood 40.81 10.62 49 118758 4006 50482311
Catatonia 40.68 10.62 47 118760 3689 50482628
Abdominal pain upper 40.64 10.62 214 118593 159095 50327222
Agitation neonatal 40.63 10.62 21 118786 482 50485835
Cellulitis 40.23 10.62 65 118742 70733 50415584
Thrombosis 40.19 10.62 43 118764 55790 50430527
Dissociation 39.74 10.62 37 118770 2254 50484063
Mucosal erosion 39.61 10.62 29 118778 1258 50485059
Low set ears 39.55 10.62 17 118790 253 50486064
Drug dose titration not performed 39.29 10.62 20 118787 444 50485873
Oedema peripheral 39.29 10.62 214 118593 157747 50328570
Chest discomfort 38.42 10.62 102 118705 92620 50393697
Femur fracture 38.35 10.62 20 118787 37444 50448873
Rapid eye movement sleep behaviour disorder 38.18 10.62 15 118792 175 50486142
Tonic convulsion 38.11 10.62 27 118780 1112 50485205
Accidental exposure to product by child 37.95 10.62 26 118781 1014 50485303
Disorientation 37.50 10.62 174 118633 35310 50451007
Vision blurred 37.44 10.62 314 118493 78333 50407984
Anticonvulsant drug level below therapeutic 37.18 10.62 21 118786 578 50485739
Antipsychotic drug level increased 37.06 10.62 41 118766 3068 50483249
Exposure via ingestion 36.98 10.62 39 118768 2764 50483553
Paradoxical drug reaction 36.59 10.62 44 118763 3603 50482714
Treatment noncompliance 36.52 10.62 154 118653 29996 50456321
Lung disorder 36.33 10.62 31 118776 44768 50441549
Renal impairment 36.31 10.62 77 118730 75584 50410733
Hypotonia 36.20 10.62 67 118740 8067 50478250
Epidermal necrosis 36.17 10.62 24 118783 887 50485430
Wheezing 36.17 10.62 56 118751 61991 50424326
Rectal haemorrhage 36.03 10.62 23 118784 38535 50447782
Metastases to liver 35.94 10.62 3 118804 20101 50466216
Erythema 35.86 10.62 512 118295 145902 50340415
Tubulointerstitial nephritis and uveitis syndrome 35.73 10.62 14 118793 162 50486155
Gamma-glutamyltransferase increased 35.64 10.62 151 118656 29472 50456845
Dysarthria 35.62 10.62 178 118629 37225 50449092
Urinary tract infection 35.61 10.62 345 118462 223675 50262642
Neoplasm progression 35.57 10.62 12 118795 29145 50457172
Blood pressure fluctuation 35.39 10.62 20 118787 35803 50450514
Osteonecrosis of jaw 35.37 10.62 16 118791 32510 50453807
Crying 35.36 10.62 117 118690 20299 50466018
Traumatic coma 35.10 10.62 11 118796 61 50486256
Disseminated intravascular coagulation 35.03 10.62 104 118703 17031 50469286
Benzodiazepine drug level increased 34.91 10.62 14 118793 173 50486144
Sinus tachycardia 34.89 10.62 120 118687 21234 50465083
Flat affect 34.82 10.62 27 118780 1278 50485039
Obsessive thoughts 34.76 10.62 19 118788 490 50485827
Central nervous system lesion 34.75 10.62 72 118735 9417 50476900
Amnesia 34.68 10.62 193 118614 42067 50444250
Melaena 34.67 10.62 10 118797 26854 50459463
Encephalopathy 34.66 10.62 164 118643 33547 50452770
Abnormal palmar/plantar creases 34.57 10.62 10 118797 40 50486277
Influenza 34.50 10.62 102 118705 89436 50396881
Nightmare 34.19 10.62 99 118708 15987 50470330
Intermenstrual bleeding 34.01 10.62 59 118748 6755 50479562
Ureteric perforation 33.99 10.62 8 118799 10 50486307
Migraine 33.96 10.62 297 118510 74983 50411334
Paranoia 33.85 10.62 75 118732 10273 50476044
Multiple congenital abnormalities 33.61 10.62 19 118788 524 50485793
Full blood count decreased 33.46 10.62 6 118801 22340 50463977
Hostility 33.29 10.62 30 118777 1752 50484565
Angiofibroma 33.21 10.62 12 118795 109 50486208
Product dispensing error 33.19 10.62 68 118739 8823 50477494
Pharyngeal erythema 33.06 10.62 28 118779 1504 50484813
Lymphangioleiomyomatosis 32.99 10.62 13 118794 153 50486164
Accessory auricle 32.91 10.62 7 118800 3 50486314
Nasal congestion 32.91 10.62 43 118764 51077 50435240
Salivary hypersecretion 32.80 10.62 57 118750 6534 50479783
Depressive symptom 32.75 10.62 39 118768 3161 50483156
Eosinophil percentage increased 32.73 10.62 23 118784 935 50485382
Mucosal inflammation 32.28 10.62 28 118779 40114 50446203
Blood lactate dehydrogenase increased 32.02 10.62 110 118697 19452 50466865
Osteoporosis 31.81 10.62 35 118772 44844 50441473
Skin erosion 31.77 10.62 33 118774 2298 50484019
Eosinophilic myocarditis 31.69 10.62 16 118791 349 50485968
Pulmonary oedema 31.67 10.62 41 118766 48897 50437420
Libido increased 31.62 10.62 25 118782 1218 50485099
Lymphadenitis 31.57 10.62 35 118772 2625 50483692
Purpura 31.49 10.62 71 118736 9840 50476477
Basal cell carcinoma 31.44 10.62 8 118799 23348 50462969
Acute respiratory distress syndrome 31.41 10.62 115 118692 20984 50465333
Pleural effusion 31.23 10.62 93 118714 81361 50404956
Bone pain 31.15 10.62 39 118768 47190 50439127
Resting tremor 30.96 10.62 20 118787 706 50485611
Bursitis 30.94 10.62 7 118800 22128 50464189
Acute myocardial infarction 30.91 10.62 15 118792 29258 50457059
Fibromyalgia 30.88 10.62 36 118771 44942 50441375
Neurotoxicity 30.64 10.62 90 118717 14650 50471667
Erythema of eyelid 30.64 10.62 29 118778 1804 50484513
Blood creatinine increased 30.63 10.62 85 118722 76075 50410242
Exomphalos 30.63 10.62 18 118789 535 50485782
Respiratory depression 30.60 10.62 79 118728 11931 50474386
Hallucination, visual 30.50 10.62 97 118710 16485 50469832
Postictal psychosis 30.48 10.62 8 118799 20 50486297
Haemoptysis 30.38 10.62 11 118796 25562 50460755
Brain death 30.28 10.62 35 118772 2748 50483569
Coma scale abnormal 30.19 10.62 46 118761 4725 50481592
Pregnancy with implant contraceptive 30.05 10.62 30 118777 1993 50484324
Weight gain poor 29.95 10.62 20 118787 747 50485570
Neonatal respiratory distress syndrome 29.93 10.62 34 118773 2620 50483697
Infantile apnoea 29.92 10.62 21 118786 852 50485465
Psoriatic arthropathy 29.82 10.62 40 118767 46992 50439325
Abdominal distension 29.59 10.62 81 118726 72822 50413495
Congenital skin dimples 29.42 10.62 11 118796 111 50486206
Hyperbilirubinaemia neonatal 29.31 10.62 15 118792 337 50485980
Cataract 29.22 10.62 41 118766 47259 50439058
Injection site bruising 29.14 10.62 26 118781 36742 50449575
Neutropenia 28.82 10.62 216 118591 147749 50338568
Hemivertebra 28.82 10.62 11 118796 118 50486199
Stomatitis 28.80 10.62 131 118676 101213 50385104
Oesophageal atresia 28.78 10.62 17 118790 510 50485807
Drug screen false positive 28.76 10.62 20 118787 799 50485518
Localised infection 28.56 10.62 12 118795 25473 50460844
Placental disorder 28.55 10.62 25 118782 1405 50484912
Respiratory disorder neonatal 28.50 10.62 21 118786 920 50485397
Gambling disorder 28.21 10.62 23 118784 1171 50485146
Bradycardia neonatal 28.18 10.62 20 118787 826 50485491
Illusion 28.15 10.62 21 118786 938 50485379
Concussion 28.08 10.62 58 118749 7570 50478747
Vomiting projectile 27.71 10.62 23 118784 1201 50485116
Chloropsia 27.65 10.62 8 118799 32 50486285
Pulmonary embolism 27.41 10.62 134 118673 101570 50384747
Brugada syndrome 27.30 10.62 14 118793 316 50486001
Pulmonary arterial hypertension 27.28 10.62 7 118800 20312 50466005
Withdrawal syndrome 27.14 10.62 97 118710 17493 50468824
Ischaemic stroke 26.87 10.62 3 118804 15945 50470372
Spina bifida 26.80 10.62 18 118789 679 50485638
Pyloric stenosis 26.79 10.62 14 118793 329 50485988
Metastases to bone 26.58 10.62 5 118802 17990 50468327
Hyperprolactinaemia 26.50 10.62 36 118771 3329 50482988
Ascites 26.50 10.62 27 118780 35834 50450483
Vestibular migraine 26.42 10.62 12 118795 205 50486112
Abortion missed 26.30 10.62 25 118782 1563 50484754
Blood pressure diastolic decreased 26.25 10.62 4 118803 16777 50469540
Vulvar erosion 26.20 10.62 11 118796 154 50486163
Seizure cluster 26.16 10.62 12 118795 210 50486107
Pulmonary hypertension 26.04 10.62 24 118783 33393 50452924
Distributive shock 26.02 10.62 19 118788 821 50485496
Injection site pruritus 26.00 10.62 34 118773 40377 50445940
Affect lability 25.89 10.62 62 118745 8936 50477381
Psychotic symptom 25.84 10.62 22 118785 1190 50485127
Blood cholesterol increased 25.82 10.62 57 118750 55158 50431159
Entropion 25.74 10.62 7 118800 21 50486296
Product administration error 25.74 10.62 103 118704 19596 50466721
Premature labour 25.72 10.62 72 118735 11404 50474913
Joint range of motion decreased 25.59 10.62 6 118801 18506 50467811
Rhabdomyolysis 25.50 10.62 168 118639 38859 50447458
Tonsillar hypertrophy 25.50 10.62 19 118788 847 50485470
Angina pectoris 25.33 10.62 15 118792 26173 50460144
Plagiocephaly 25.29 10.62 8 118799 46 50486271
Heart rate decreased 25.28 10.62 29 118778 36468 50449849
Haematochezia 25.21 10.62 34 118773 39848 50446469
Galactorrhoea 25.13 10.62 37 118770 3686 50482631
Chronic kidney disease 25.04 10.62 34 118773 39737 50446580
Eye movement disorder 24.86 10.62 41 118766 4504 50481813
Drug hypersensitivity 24.85 10.62 427 118380 250583 50235734
Haemorrhoids 24.75 10.62 7 118800 19046 50467271
Loss of personal independence in daily activities 24.73 10.62 83 118724 69967 50416350
Hypoglycaemia neonatal 24.70 10.62 19 118788 889 50485428
Distractibility 24.54 10.62 14 118793 393 50485924
Cerebral infarction 24.49 10.62 10 118797 21594 50464723
Cytomegalovirus infection 24.48 10.62 6 118801 17956 50468361
Oral mucosal blistering 24.45 10.62 42 118765 4770 50481547
Derealisation 24.40 10.62 20 118787 1026 50485291
Pregnancy on contraceptive 24.30 10.62 20 118787 1032 50485285
Osteomyelitis 24.30 10.62 11 118796 22342 50463975
Hypomagnesaemia 24.24 10.62 12 118795 23144 50463173
Psychomotor skills impaired 24.23 10.62 27 118780 2037 50484280
Myocarditis 24.21 10.62 56 118751 7891 50478426
Retinogram abnormal 24.14 10.62 10 118797 135 50486182
Irregular sleep phase 24.12 10.62 6 118801 11 50486306
Cataplexy 24.07 10.62 20 118787 1046 50485271
Flight of ideas 24.00 10.62 13 118794 329 50485988
Attention deficit hyperactivity disorder 23.87 10.62 29 118778 2400 50483917
Learning disorder 23.86 10.62 16 118791 602 50485715
Anomalous pulmonary venous connection 23.83 10.62 8 118799 57 50486260
Neoplasm malignant 23.77 10.62 13 118794 23702 50462615
Electrocardiogram ST segment depression 23.69 10.62 30 118777 2590 50483727
Hypokalaemia 23.67 10.62 116 118691 87876 50398441
Lymphocytic infiltration 23.66 10.62 18 118789 828 50485489
Symblepharon 23.59 10.62 8 118799 59 50486258
Panic attack 23.58 10.62 99 118708 19243 50467074
Lung neoplasm malignant 23.53 10.62 4 118803 15480 50470837
Macular degeneration 23.52 10.62 3 118804 14385 50471932
Hepatosplenomegaly 23.37 10.62 28 118779 2284 50484033
Congenital anomaly in offspring 23.25 10.62 10 118797 149 50486168
Miosis 23.25 10.62 48 118759 6262 50480055
Intention tremor 23.24 10.62 13 118794 351 50485966
Colitis 23.20 10.62 34 118773 38495 50447822
Sternal fracture 23.18 10.62 26 118781 1976 50484341
Cerebral atrophy 23.17 10.62 40 118767 4561 50481756
Negative symptoms in schizophrenia 23.14 10.62 9 118798 102 50486215
Poor sucking reflex 23.07 10.62 11 118796 211 50486106
Choroidal coloboma 22.94 10.62 5 118802 3 50486314
Persistent left superior vena cava 22.94 10.62 7 118800 35 50486282
Congenital hand malformation 22.84 10.62 12 118795 285 50486032
Persistent depressive disorder 22.84 10.62 18 118789 873 50485444
Decreased appetite 22.83 10.62 333 118474 200590 50285727
Transaminases increased 22.77 10.62 127 118680 27697 50458620
Educational problem 22.75 10.62 13 118794 366 50485951
Product quality issue 22.75 10.62 137 118670 30721 50455596
Stereotypy 22.66 10.62 13 118794 369 50485948
Cystitis 22.53 10.62 44 118763 44520 50441797
Hyperammonaemia 22.41 10.62 40 118767 4684 50481633
Photosensitivity reaction 22.37 10.62 74 118733 12837 50473480
Hepatic function abnormal 22.16 10.62 142 118665 32539 50453778
Staring 22.15 10.62 22 118785 1452 50484865
Pseudolymphoma 22.12 10.62 15 118792 575 50485742
Soft tissue injury 22.03 10.62 22 118785 1462 50484855
Head titubation 22.00 10.62 16 118791 687 50485630
Retinal pigment epitheliopathy 21.96 10.62 10 118797 172 50486145
Red blood cell sedimentation rate increased 21.90 10.62 22 118785 29394 50456923
Dysphemia 21.80 10.62 27 118780 2279 50484038
Anaphylactic shock 21.78 10.62 10 118797 20145 50466172
Lymphocyte stimulation test positive 21.72 10.62 14 118793 492 50485825
Palmar-plantar erythrodysaesthesia syndrome 21.68 10.62 10 118797 20088 50466229
Thyroiditis 21.67 10.62 24 118783 1798 50484519
Acquired immunodeficiency syndrome 21.64 10.62 8 118799 78 50486239
Coprolalia 21.59 10.62 6 118801 20 50486297
Major depression 21.52 10.62 49 118758 6835 50479482
Hypervolaemia 21.47 10.62 17 118790 25482 50460835
Skin ulcer 21.43 10.62 31 118776 35287 50451030
Pregnancy with contraceptive device 21.25 10.62 36 118771 4043 50482274
Sleep paralysis 21.08 10.62 14 118793 518 50485799
Cholestasis of pregnancy 21.05 10.62 19 118788 1112 50485205
Hospitalisation 21.02 10.62 85 118722 67852 50418465
Gastric ulcer 20.90 10.62 12 118795 21293 50465024
Nephrogenic diabetes insipidus 20.88 10.62 17 118790 864 50485453
Dysphoria 20.84 10.62 39 118768 4735 50481582
Night sweats 20.84 10.62 29 118778 33545 50452772
Change in seizure presentation 20.80 10.62 11 118796 265 50486052
Delivery 20.70 10.62 15 118792 640 50485677
Aphasia 20.69 10.62 126 118681 28368 50457949
Upper gastrointestinal haemorrhage 20.63 10.62 6 118801 16029 50470288
Conjunctival disorder 20.50 10.62 10 118797 202 50486115
Cardiac malposition 20.48 10.62 7 118800 53 50486264
Genital erosion 20.46 10.62 9 118798 142 50486175
Cardiac disorder 20.40 10.62 44 118763 42935 50443382
Automatism 20.37 10.62 7 118800 54 50486263
Skin exfoliation 20.35 10.62 142 118665 33470 50452847
Self-medication 20.28 10.62 26 118781 2273 50484044
Self esteem decreased 20.23 10.62 14 118793 555 50485762
Oral hairy leukoplakia 20.23 10.62 4 118803 0 50486317
Lip scab 20.23 10.62 4 118803 0 50486317
Interstitial lung disease 20.17 10.62 61 118746 53115 50433202
Heart rate increased 20.11 10.62 103 118704 77147 50409170
Angiomyolipoma 20.11 10.62 10 118797 211 50486106
Muscle spasms 20.08 10.62 193 118614 125360 50360957
Drug ineffective for unapproved indication 20.06 10.62 101 118706 21180 50465137
Feeling drunk 20.05 10.62 33 118774 3620 50482697
Injury corneal 20.04 10.62 7 118800 57 50486260
Hypocalcaemia 20.03 10.62 20 118787 26796 50459521
Foetal death 20.01 10.62 53 118754 8127 50478190
Disinhibition 19.98 10.62 16 118791 794 50485523
Haematocrit decreased 19.97 10.62 32 118775 34944 50451373
Bile acid malabsorption 19.96 10.62 9 118798 151 50486166
Illogical thinking 19.93 10.62 7 118800 58 50486259
Device related infection 19.88 10.62 12 118795 20723 50465594
Congenital anomaly 19.78 10.62 21 118786 1500 50484817
Mouth ulceration 19.77 10.62 123 118684 27901 50458416
Pulmonary fibrosis 19.70 10.62 17 118790 24420 50461897
Arnold-Chiari malformation 19.65 10.62 13 118794 478 50485839
Limbic encephalitis 19.61 10.62 10 118797 223 50486094
Granulocytopenia 19.52 10.62 40 118767 5191 50481126
Tachyphrenia 19.49 10.62 19 118788 1226 50485091
Tension 19.45 10.62 28 118779 2734 50483583
Hereditary ataxia 19.34 10.62 6 118801 32 50486285
Self-injurious ideation 19.33 10.62 25 118782 2204 50484113
Macule 19.32 10.62 21 118786 1541 50484776
Dysmetria 19.27 10.62 12 118795 397 50485920
Abnormal dreams 19.25 10.62 57 118750 9320 50476997
Drug resistance 19.24 10.62 92 118715 18897 50467420
Haematemesis 19.23 10.62 22 118785 27703 50458614
Dermatitis bullous 19.12 10.62 48 118759 7125 50479192
Dermatitis exfoliative 18.81 10.62 39 118768 5103 50481214
Echolalia 18.81 10.62 9 118798 174 50486143
Somnambulism 18.78 10.62 38 118769 4886 50481431
Abortion 18.70 10.62 24 118783 2100 50484217
External auditory canal atresia 18.69 10.62 7 118800 71 50486246
Scab 18.65 10.62 45 118762 6517 50479800
Laryngeal ulceration 18.64 10.62 5 118802 14 50486303
Oral mucosal eruption 18.61 10.62 14 118793 633 50485684
Contusion 18.55 10.62 171 118636 112012 50374305
Hiatus hernia 18.47 10.62 10 118797 18334 50467983
Overweight 18.47 10.62 29 118778 3057 50483260
Sinus congestion 18.40 10.62 5 118802 13966 50472351
Inflammation 18.38 10.62 70 118737 56842 50429475
Periodic limb movement disorder 18.35 10.62 9 118798 184 50486133
Agranulocytosis 18.35 10.62 99 118708 21322 50464995
Drop attacks 18.33 10.62 14 118793 648 50485669
Sciatica 18.33 10.62 14 118793 21368 50464949
Off label use 18.29 10.62 919 117888 473507 50012810
Coma scale 18.21 10.62 6 118801 40 50486277
Creatinine renal clearance decreased 18.21 10.62 3 118804 11878 50474439
Bradykinesia 18.21 10.62 33 118774 3910 50482407
Lipids 18.15 10.62 5 118802 16 50486301
Confusional state 18.14 10.62 568 118239 185360 50300957
Alopecia universalis 18.10 10.62 7 118800 78 50486239
Hippocampal sclerosis 18.10 10.62 7 118800 78 50486239
Iris coloboma 18.09 10.62 6 118801 41 50486276
Lipids abnormal 18.08 10.62 10 118797 264 50486053
Oedema 18.03 10.62 94 118713 70087 50416230
Joint stiffness 18 10.62 27 118780 30281 50456036
Congenital anaemia 18.00 10.62 4 118803 3 50486314
Foetal heart rate deceleration abnormality 17.95 10.62 12 118795 449 50485868
Cerebral ventricle dilatation 17.95 10.62 16 118791 921 50485396
Tricuspid valve incompetence 17.93 10.62 4 118803 12766 50473551
Oscillopsia 17.92 10.62 8 118799 131 50486186
Histiocytosis 17.92 10.62 5 118802 17 50486300
Meningomyelocele 17.88 10.62 13 118794 558 50485759
Mononucleosis syndrome 17.87 10.62 8 118799 132 50486185
Gastric disorder 17.86 10.62 26 118781 29522 50456795
Borderline personality disorder 17.85 10.62 14 118793 674 50485643
Injection site reaction 17.85 10.62 59 118748 49973 50436344
Peritonitis 17.83 10.62 7 118800 15479 50470838
Drooling 17.81 10.62 30 118777 3354 50482963
Negativism 17.80 10.62 11 118796 359 50485958
Alanine aminotransferase increased 17.79 10.62 299 118508 88060 50398257
Postictal state 17.76 10.62 16 118791 934 50485383
Brachycephaly 17.70 10.62 5 118802 18 50486299
Upper respiratory tract infection 17.65 10.62 87 118720 65811 50420506
Cleft palate 17.57 10.62 16 118791 947 50485370
Spinal stenosis 17.56 10.62 5 118802 13545 50472772
Blood creatine phosphokinase increased 17.53 10.62 114 118693 26253 50460064
Psychiatric decompensation 17.49 10.62 18 118789 1240 50485077
Post-traumatic neck syndrome 17.48 10.62 22 118785 1888 50484429
Septic shock 17.40 10.62 72 118735 57103 50429214
Ejection fraction decreased 17.37 10.62 11 118796 18509 50467808
Platelet count decreased 17.33 10.62 152 118655 100574 50385743
Increased appetite 17.33 10.62 51 118756 8310 50478007
Middle insomnia 17.31 10.62 57 118750 9864 50476453
Injection site swelling 17.26 10.62 46 118761 41727 50444590
Viral rash 17.24 10.62 10 118797 290 50486027
Brain oedema 17.23 10.62 66 118741 12304 50474013
Haematuria 17.05 10.62 21 118786 25592 50460725
Normal newborn 17.03 10.62 44 118763 6647 50479670
Learning disability 17.01 10.62 9 118798 217 50486100
Metastases to central nervous system 16.96 10.62 3 118804 11279 50475038
Throat irritation 16.95 10.62 28 118779 30211 50456106
Mitral valve incompetence 16.91 10.62 10 118797 17461 50468856
Neurosurgery 16.90 10.62 5 118802 22 50486295
Cerebellar ataxia 16.83 10.62 15 118792 863 50485454
Hepatitis 16.82 10.62 129 118678 31324 50454993
Gestational hypertension 16.74 10.62 23 118784 2150 50484167
Parachute mitral valve 16.74 10.62 7 118800 97 50486220
Strabismus 16.62 10.62 21 118786 1809 50484508
Pre-eclampsia 16.61 10.62 49 118758 7995 50478322
Immunodeficiency 16.59 10.62 7 118800 14821 50471496
Suicide threat 16.55 10.62 5 118802 24 50486293
Product dose omission issue 16.52 10.62 318 118489 183520 50302797
Sleep-related eating disorder 16.50 10.62 14 118793 754 50485563
Screaming 16.47 10.62 27 118780 2951 50483366
Epstein-Barr virus infection reactivation 16.40 10.62 12 118795 520 50485797
Anal erosion 16.38 10.62 5 118802 25 50486292
Poor feeding infant 16.36 10.62 9 118798 235 50486082
Corneal erosion 16.33 10.62 9 118798 236 50486081
Transfusion 16.29 10.62 5 118802 12900 50473417
Suppressed lactation 16.24 10.62 11 118796 421 50485896
Bradyphrenia 16.22 10.62 41 118766 6111 50480206
White blood cell count increased 16.20 10.62 161 118646 42079 50444238
Cleft lip 16.18 10.62 7 118800 106 50486211
Hypersomnia 16.11 10.62 75 118732 15239 50471078
Cerebellar atrophy 16.08 10.62 13 118794 654 50485663
Hypercapnic coma 16.08 10.62 8 118799 169 50486148
Weight decreased 16.05 10.62 396 118411 220849 50265468
Psychiatric symptom 15.95 10.62 34 118773 4536 50481781
Anorgasmia 15.95 10.62 12 118795 543 50485774
Tonic clonic movements 15.95 10.62 17 118790 1220 50485097
Herpangina 15.91 10.62 5 118802 28 50486289
Cardiac aneurysm 15.87 10.62 14 118793 795 50485522
Injection site haemorrhage 15.85 10.62 16 118791 21330 50464987
Osteochondrosis 15.84 10.62 16 118791 1078 50485239
Gait deviation 15.83 10.62 6 118801 63 50486254
Bipolar II disorder 15.83 10.62 9 118798 251 50486066
Urinary incontinence 15.82 10.62 117 118690 28091 50458226
Breast cancer 15.70 10.62 50 118757 42840 50443477
Hypercalcaemia 15.70 10.62 19 118788 23333 50462984
Myelodysplastic syndrome 15.60 10.62 8 118799 15124 50471193
Congenital aortic valve stenosis 15.51 10.62 6 118801 67 50486250
Hip fracture 15.50 10.62 23 118784 25908 50460409
Adrenal insufficiency 15.50 10.62 7 118800 14236 50472081
Maternal exposure before pregnancy 15.50 10.62 38 118769 5559 50480758
Urinary retention 15.48 10.62 110 118697 26080 50460237
Congenital ureteric anomaly 15.43 10.62 6 118801 68 50486249
Vulval disorder 15.37 10.62 13 118794 697 50485620
Developmental delay 15.31 10.62 17 118790 1277 50485040
Lymph node pain 15.30 10.62 17 118790 1278 50485039
Lennox-Gastaut syndrome 15.30 10.62 9 118798 268 50486049
Congenital oesophageal anomaly 15.24 10.62 4 118803 10 50486307
Selective IgA immunodeficiency 15.24 10.62 4 118803 10 50486307
Retinal coloboma 15.22 10.62 5 118802 33 50486284
Laryngeal tremor 15.17 10.62 3 118804 0 50486317
Pharyngeal exudate 15.17 10.62 3 118804 0 50486317
Pulmonary mass 15.09 10.62 13 118794 18692 50467625
Placental infarction 15.06 10.62 9 118798 276 50486041
Speech disorder developmental 15.03 10.62 12 118795 593 50485724
Attention-seeking behaviour 14.97 10.62 6 118801 74 50486243
Polyhydramnios 14.95 10.62 21 118786 2004 50484313
Spinal fracture 14.95 10.62 9 118798 15564 50470753
Apnoea 14.93 10.62 43 118764 6923 50479394
Blood glucose increased 14.91 10.62 102 118705 71222 50415095
Dysmetropsia 14.90 10.62 6 118801 75 50486242
Drug level fluctuating 14.89 10.62 10 118797 377 50485940
Morose 14.85 10.62 5 118802 36 50486281
Pneumocystis jirovecii pneumonia 14.75 10.62 8 118799 14655 50471662
Bezoar 14.75 10.62 17 118790 1331 50484986
Nodule 14.74 10.62 11 118796 16992 50469325
Tearfulness 14.72 10.62 29 118778 3658 50482659
Oral mucosal erythema 14.67 10.62 17 118790 1338 50484979
Gastritis 14.65 10.62 35 118772 32948 50453369
Drug ineffective 14.63 10.62 1693 117114 817640 49668677
Drug withdrawal syndrome 14.63 10.62 105 118702 24976 50461341
Homicidal ideation 14.62 10.62 19 118788 1683 50484634
Economic problem 14.62 10.62 20 118787 1862 50484455
Toothache 14.56 10.62 11 118796 16883 50469434
Bone density decreased 14.52 10.62 4 118803 11071 50475246
Skin lesion 14.51 10.62 110 118697 26617 50459700
Conjunctival ulcer 14.50 10.62 5 118802 39 50486278
Dyspepsia 14.50 10.62 108 118699 73989 50412328
Tuberculosis 14.48 10.62 3 118804 10080 50476237
Transient ischaemic attack 14.45 10.62 34 118773 32176 50454141
Haemangioma 14.42 10.62 23 118784 2457 50483860
SJS-TEN overlap 14.40 10.62 8 118799 213 50486104
Blood prolactin increased 14.39 10.62 26 118781 3073 50483244
Conjunctival oedema 14.39 10.62 12 118795 631 50485686
Epidermolysis 14.34 10.62 8 118799 215 50486102
Delusional perception 14.27 10.62 8 118799 217 50486100
Acute myopia 14.23 10.62 6 118801 85 50486232
Hyperventilation 14.21 10.62 36 118771 5373 50480944
Hallucination, olfactory 14.17 10.62 8 118799 220 50486097
Heavy menstrual bleeding 14.13 10.62 73 118734 15464 50470853
Spinal compression fracture 14.12 10.62 6 118801 12650 50473667
Therapeutic product effective for unapproved indication 14.04 10.62 6 118801 88 50486229
Abulia 14.00 10.62 10 118797 417 50485900
Hypoxia 13.97 10.62 67 118740 51056 50435261
Fungal infection 13.95 10.62 31 118776 29934 50456383
Drug screen positive 13.88 10.62 27 118780 3375 50482942
Antipsychotic drug level above therapeutic 13.84 10.62 14 118793 945 50485372
Aspergillus test positive 13.82 10.62 9 118798 322 50485995
Myalgia 13.78 10.62 207 118600 124112 50362205
Cellulitis orbital 13.78 10.62 10 118797 428 50485889
Lactation disorder 13.75 10.62 9 118798 325 50485992
Spinal osteoarthritis 13.73 10.62 8 118799 14084 50472233
Eclampsia 13.72 10.62 9 118798 326 50485991
Body temperature decreased 13.72 10.62 11 118796 16384 50469933
Skin disorder 13.67 10.62 100 118707 23930 50462387
Premature rupture of membranes 13.65 10.62 32 118775 4548 50481769
Hepatocellular injury 13.64 10.62 106 118701 25841 50460476
Foetal malnutrition 13.62 10.62 6 118801 95 50486222
Eyelid oedema 13.59 10.62 51 118756 9415 50476902
Brain stem syndrome 13.58 10.62 9 118798 332 50485985
Musculoskeletal chest pain 13.56 10.62 14 118793 18472 50467845
Menstrual disorder 13.54 10.62 31 118776 4339 50481978
Bacterial infection 13.53 10.62 11 118796 16270 50470047
Gastroschisis 13.52 10.62 8 118799 241 50486076
Gout 13.51 10.62 5 118802 11465 50474852
Delusion of reference 13.40 10.62 6 118801 99 50486218
Rhinorrhoea 13.30 10.62 69 118738 51514 50434803
Tongue biting 13.27 10.62 16 118791 1314 50485003
Joint effusion 13.25 10.62 7 118800 13014 50473303
Hepatic cirrhosis 13.25 10.62 13 118794 17564 50468753
Wound infection 13.17 10.62 6 118801 12142 50474175
Roseolovirus test positive 13.15 10.62 5 118802 53 50486264
Pigmentation disorder 13.13 10.62 28 118779 3736 50482581
Breast cancer metastatic 13.11 10.62 4 118803 10360 50475957
Exposure via transplant 13.11 10.62 4 118803 20 50486297
Multiple organ dysfunction syndrome 13.10 10.62 178 118629 50159 50436158
Congenital emphysema 13.10 10.62 3 118804 3 50486314
Manic symptom 13.10 10.62 3 118804 3 50486314
Niemann-Pick disease 13.10 10.62 3 118804 3 50486314
Sleep disorder 13.09 10.62 198 118609 57085 50429232
Skin cancer 13.07 10.62 3 118804 9391 50476926
Adverse drug reaction 13.07 10.62 76 118731 55146 50431171
Pulmonary congestion 13.05 10.62 10 118797 15237 50471080
Polydipsia 12.99 10.62 25 118782 3099 50483218
Deja vu 12.99 10.62 5 118802 55 50486262
Acquired epidermolysis bullosa 12.99 10.62 5 118802 55 50486262
Cardiomegaly 12.97 10.62 11 118796 15934 50470383
Eosinophilic pneumonia 12.97 10.62 19 118788 1885 50484432
Clostridium difficile infection 12.96 10.62 25 118782 25414 50460903
Combined immunodeficiency 12.93 10.62 6 118801 108 50486209
Blood magnesium decreased 12.92 10.62 5 118802 11155 50475162
Musculoskeletal disorder 12.89 10.62 13 118794 17336 50468981
Hepatotoxicity 12.81 10.62 28 118779 27198 50459119
Heart rate irregular 12.75 10.62 16 118791 19344 50466973
Lip disorder 12.73 10.62 15 118792 1202 50485115
Myelosuppression 12.71 10.62 8 118799 13509 50472808
White blood cell count decreased 12.71 10.62 195 118612 116527 50369790
Cardiovascular symptom 12.68 10.62 5 118802 59 50486258
Blood pressure decreased 12.68 10.62 78 118729 55831 50430486
Personality disorder 12.66 10.62 30 118777 4294 50482023
Metastases to lung 12.66 10.62 5 118802 11015 50475302
Lymphoid tissue hyperplasia 12.65 10.62 7 118800 185 50486132
Holoprosencephaly 12.64 10.62 4 118803 23 50486294
Directional Doppler flow tests abnormal 12.64 10.62 3 118804 4 50486313
Foot deformity 12.52 10.62 16 118791 19194 50467123
Status migrainosus 12.49 10.62 6 118801 117 50486200
Oesophagitis 12.48 10.62 8 118799 13375 50472942
Medication overuse headache 12.48 10.62 11 118796 624 50485693
Emotional disorder 12.47 10.62 58 118749 11778 50474539
Epidermolysis bullosa 12.45 10.62 6 118801 118 50486199
Palpitations 12.40 10.62 152 118655 94354 50391963
Foetal growth restriction 12.40 10.62 39 118768 6588 50479729
Social avoidant behaviour 12.40 10.62 23 118784 2774 50483543
Retinal pigmentation 12.38 10.62 5 118802 63 50486254
Initial insomnia 12.37 10.62 33 118774 5082 50481235
Retroperitoneal fibrosis 12.32 10.62 8 118799 285 50486032
Unemployment 12.24 10.62 3 118804 5 50486312
Colitis ulcerative 12.10 10.62 13 118794 16841 50469476
Cytotoxic oedema 12.09 10.62 6 118801 126 50486191
Body height decreased 12.09 10.62 3 118804 8905 50477412
Anembryonic gestation 12.02 10.62 10 118797 524 50485793
Hypothermia 12.02 10.62 58 118749 11958 50474359
Flank pain 12.01 10.62 8 118799 13107 50473210
Delusional disorder, erotomanic type 11.98 10.62 4 118803 28 50486289
Phonophobia 11.93 10.62 8 118799 301 50486016
Diverticulum 11.89 10.62 5 118802 10609 50475708
Wound healing normal 11.89 10.62 3 118804 6 50486311
Atrophy of globe 11.89 10.62 3 118804 6 50486311
Flashback 11.84 10.62 6 118801 132 50486185
Emotional poverty 11.84 10.62 8 118799 305 50486012
Drowning 11.83 10.62 9 118798 414 50485903
Odynophagia 11.82 10.62 38 118769 6494 50479823
Dysphonia 11.82 10.62 49 118758 38843 50447474
Tongue eruption 11.78 10.62 5 118802 72 50486245
Interleukin-2 receptor increased 11.78 10.62 5 118802 72 50486245
Pityriasis rosea 11.78 10.62 5 118802 72 50486245
Stupor 11.75 10.62 26 118781 3557 50482760
Gastroenteritis 11.75 10.62 23 118784 23258 50463059
COVID-19 11.70 10.62 63 118744 46599 50439718
Hepatic encephalopathy 11.69 10.62 4 118803 9632 50476685
Device issue 11.66 10.62 18 118789 19954 50466363
Homeless 11.66 10.62 5 118802 74 50486243
Grip strength decreased 11.64 10.62 7 118800 12114 50474203
Intestinal perforation 11.64 10.62 5 118802 10474 50475843
Lymphoma 11.63 10.62 4 118803 9597 50476720
Mucosa vesicle 11.62 10.62 4 118803 31 50486286
Regressive behaviour 11.60 10.62 5 118802 75 50486242
Dry skin 11.58 10.62 57 118750 43134 50443183
Blunted affect 11.53 10.62 7 118800 221 50486096
Oxygen saturation decreased 11.53 10.62 113 118694 73135 50413182
Bankruptcy 11.51 10.62 4 118803 32 50486285
Hallucinations, mixed 11.51 10.62 28 118779 4075 50482242
Hyperphagia 11.48 10.62 16 118791 1516 50484801
Head injury 11.47 10.62 96 118711 23924 50462393
Sinus disorder 11.40 10.62 16 118791 18442 50467875
Decreased interest 11.39 10.62 23 118784 2953 50483364
Fulminant type 1 diabetes mellitus 11.39 10.62 8 118799 325 50485992
Neuropsychiatric symptoms 11.32 10.62 10 118797 569 50485748
Bronchiectasis 11.27 10.62 5 118802 10278 50476039
Poor weight gain neonatal 11.25 10.62 5 118802 81 50486236
Monocyte percentage increased 11.17 10.62 13 118794 1028 50485289
Decreased eye contact 11.15 10.62 7 118800 235 50486082
Therapy non-responder 11.15 10.62 72 118735 50950 50435367
Cogwheel rigidity 11.06 10.62 17 118790 1760 50484557
Injection site rash 11.05 10.62 13 118794 16164 50470153
Congenital gastric anomaly 11.03 10.62 3 118804 9 50486308
Tonsillar haemorrhage 11.02 10.62 7 118800 240 50486077
Hyperglycaemia 10.98 10.62 46 118761 36359 50449958
Conversion disorder 10.97 10.62 16 118791 1580 50484737
Spinal cord infarction 10.96 10.62 7 118800 242 50486075
Malignant melanoma 10.95 10.62 5 118802 10103 50476214
Dermatosis 10.94 10.62 7 118800 243 50486074
Vulval oedema 10.91 10.62 4 118803 38 50486279
Lymphocytosis 10.90 10.62 19 118788 2183 50484134
Blood calcium decreased 10.85 10.62 20 118787 20686 50465631
Visual field defect 10.80 10.62 34 118773 5745 50480572
Induced labour 10.80 10.62 12 118795 902 50485415
Tendonitis 10.80 10.62 14 118793 16691 50469626
Head circumference abnormal 10.79 10.62 3 118804 10 50486307
Alexia 10.79 10.62 3 118804 10 50486307
Blood iron decreased 10.75 10.62 7 118800 11608 50474709
Liver function test increased 10.73 10.62 28 118779 25578 50460739
Osteonecrosis 10.73 10.62 23 118784 22494 50463823
Ocular hyperaemia 10.72 10.62 83 118724 20209 50466108
Nikolsky's sign 10.67 10.62 5 118802 92 50486225
Lip haemorrhage 10.67 10.62 9 118798 481 50485836
Clumsiness 10.64 10.62 17 118790 1819 50484498
Drug level changed 10.63 10.62 6 118801 165 50486152

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1365.74 11.85 1307 61672 91816 29419732
Foetal exposure during pregnancy 982.20 11.85 707 62272 33160 29478388
Stevens-Johnson syndrome 653.44 11.85 418 62561 16079 29495469
Completed suicide 549.05 11.85 809 62170 89437 29422111
Generalised tonic-clonic seizure 468.01 11.85 361 62618 18778 29492770
Drug reaction with eosinophilia and systemic symptoms 466.56 11.85 423 62556 27569 29483979
Status epilepticus 416.16 11.85 269 62710 10525 29501023
Product substitution issue 389.54 11.85 243 62736 8929 29502619
Toxicity to various agents 351.81 11.85 984 61995 172677 29338871
Aggression 330.85 11.85 393 62586 35148 29476400
Ataxia 321.65 11.85 240 62739 11863 29499685
Epilepsy 313.80 11.85 282 62697 18150 29493398
Exposure during pregnancy 304.90 11.85 203 62776 8351 29503197
Atrial septal defect 258.71 11.85 168 62811 6621 29504927
Suicide attempt 226.15 11.85 319 62660 33791 29477757
Toxic epidermal necrolysis 224.50 11.85 233 62746 17920 29493628
Agitation 212.33 11.85 387 62592 50917 29460631
Diarrhoea 210.44 11.85 240 62739 332458 29179090
Febrile neutropenia 204.26 11.85 8 62971 112232 29399316
Rash 202.07 11.85 869 62110 188950 29322598
Dyspnoea 197.73 11.85 244 62735 326488 29185060
Somnolence 195.15 11.85 538 62441 93417 29418131
Intentional overdose 170.08 11.85 299 62680 38229 29473319
Death 165.59 11.85 298 62681 341786 29169762
Pneumonia 163.99 11.85 269 62710 319903 29191645
Exposure via breast milk 158.51 11.85 76 62903 1636 29509912
Anaemia 157.39 11.85 119 62860 200832 29310716
Drug interaction 156.39 11.85 830 62149 196555 29314993
Partial seizures 154.65 11.85 99 62880 3804 29507744
Hypospadias 154.47 11.85 90 62889 2912 29508636
Mania 152.25 11.85 135 62844 8528 29503020
Abnormal behaviour 146.92 11.85 212 62767 22915 29488633
Irritability 146.51 11.85 207 62772 21945 29489603
Acute kidney injury 144.15 11.85 214 62765 265053 29246495
Sudden unexplained death in epilepsy 136.33 11.85 47 62932 409 29511139
Cardiac failure congestive 128.20 11.85 9 62970 76572 29434976
Myocardial infarction 126.16 11.85 39 62940 110257 29401291
Patent ductus arteriosus 125.49 11.85 80 62899 3051 29508497
Infantile apnoea 122.42 11.85 52 62927 833 29510715
Maternal exposure during breast feeding 119.73 11.85 60 62919 1426 29510122
Autism spectrum disorder 118.19 11.85 66 62913 1966 29509582
Ventricular septal defect 116.77 11.85 80 62899 3449 29508099
Respiratory disorder neonatal 116.18 11.85 58 62921 1367 29510181
Petit mal epilepsy 112.72 11.85 71 62908 2651 29508897
Drug withdrawal syndrome neonatal 112.42 11.85 77 62902 3318 29508230
Rash maculo-papular 111.70 11.85 192 62787 24097 29487451
Overdose 110.16 11.85 397 62582 79422 29432126
Maternal exposure during pregnancy 110.03 11.85 82 62897 4041 29507507
Dysmorphism 107.03 11.85 71 62908 2900 29508648
Brugada syndrome 106.38 11.85 44 62935 657 29510891
Maternal drugs affecting foetus 105.18 11.85 78 62901 3815 29507733
Neonatal respiratory distress syndrome 104.42 11.85 77 62902 3733 29507815
Coma 103.60 11.85 247 62732 39203 29472345
Cognitive disorder 103.17 11.85 182 62797 23317 29488231
Congenital anomaly 102.26 11.85 52 62927 1276 29510272
Drug eruption 101.29 11.85 150 62829 16591 29494957
Hypomania 100.91 11.85 61 62918 2114 29509434
Myoclonus 99.51 11.85 132 62847 13177 29498371
Speech disorder developmental 97.66 11.85 57 62922 1850 29509698
Conjunctival hyperaemia 96.54 11.85 59 62920 2086 29509462
Multiple-drug resistance 96.19 11.85 74 62905 3826 29507722
Malignant neoplasm progression 96.19 11.85 20 62959 73839 29437709
Atrial fibrillation 95.59 11.85 53 62926 105593 29405955
Lip erosion 94.51 11.85 37 62942 475 29511073
Arthralgia 94.25 11.85 95 62884 139522 29372026
Selective eating disorder 93.97 11.85 53 62926 1610 29509938
Oculogyric crisis 92.47 11.85 49 62930 1312 29510236
Oral mucosa erosion 92.31 11.85 42 62937 799 29510749
Attention deficit hyperactivity disorder 92.23 11.85 58 62921 2159 29509389
Electrocardiogram QRS complex prolonged 88.51 11.85 72 62907 4038 29507510
Focal dyscognitive seizures 87.90 11.85 46 62933 1200 29510348
Haemophagocytic lymphohistiocytosis 87.64 11.85 110 62869 10394 29501154
Developmental delay 85.49 11.85 58 62921 2460 29509088
Hypotonia neonatal 85.29 11.85 45 62934 1194 29510354
Psychomotor hyperactivity 85.00 11.85 96 62883 8117 29503431
Intentional self-injury 84.68 11.85 118 62861 12343 29499205
Interstitial lung disease 83.09 11.85 12 62967 57706 29453842
Pain 82.91 11.85 149 62830 171283 29340265
Bradycardia neonatal 81.81 11.85 40 62939 900 29510648
Suicidal ideation 81.24 11.85 208 62771 34508 29477040
Cardiac failure 80.50 11.85 34 62945 79253 29432295
Neonatal infection 80.32 11.85 31 62948 382 29511166
Obsessive-compulsive disorder 79.78 11.85 71 62908 4505 29507043
Crying 79.64 11.85 76 62903 5275 29506273
Accidental exposure to product by child 78.81 11.85 44 62935 1310 29510238
Neurodevelopmental disorder 78.75 11.85 29 62950 311 29511237
Agitation neonatal 77.40 11.85 40 62939 1016 29510532
Drug level increased 72.96 11.85 138 62841 18649 29492899
Cough 72.83 11.85 98 62881 126629 29384919
Disease progression 72.78 11.85 42 62937 81874 29429674
Electroencephalogram abnormal 72.71 11.85 51 62928 2284 29509264
Aura 72.70 11.85 27 62952 297 29511251
Sepsis 72.63 11.85 120 62859 142562 29368986
Postictal psychosis 72.20 11.85 23 62956 152 29511396
Pain in extremity 69.10 11.85 80 62899 110353 29401195
Coronary artery disease 68.97 11.85 7 62972 44183 29467365
Disturbance in attention 66.07 11.85 143 62836 21281 29490267
Neonatal tachypnoea 64.28 11.85 21 62958 152 29511396
Pulmonary embolism 64.15 11.85 42 62937 76492 29435056
Sedation 64.08 11.85 125 62854 17280 29494268
Restlessness 63.98 11.85 144 62835 22001 29489547
Haemoglobin decreased 63.08 11.85 83 62896 108292 29403256
Oedema peripheral 62.67 11.85 77 62902 103480 29408068
Conjunctivitis 62.37 11.85 81 62898 7917 29503631
Gastrointestinal haemorrhage 62.24 11.85 47 62932 79486 29432062
Anger 62.20 11.85 95 62884 10795 29500753
Joint swelling 61.47 11.85 15 62964 49615 29461933
Bipolar disorder 61.20 11.85 53 62926 3242 29508306
Balance disorder 60.50 11.85 192 62787 35978 29475570
Talipes 60.18 11.85 41 62938 1751 29509797
Back pain 59.87 11.85 78 62901 102206 29409342
Abdominal pain 59.86 11.85 124 62855 135233 29376315
Infection 59.23 11.85 46 62933 76705 29434843
Gaze palsy 59.15 11.85 36 62943 1263 29510285
Tardive dyskinesia 58.79 11.85 64 62915 5194 29506354
Premature baby 58.70 11.85 120 62859 17160 29494388
Tremor 58.48 11.85 310 62669 73228 29438320
Psychotic disorder 58.41 11.85 132 62847 20222 29491326
Nystagmus 58.14 11.85 58 62921 4251 29507297
Acute myocardial infarction 57.39 11.85 16 62963 48422 29463126
Mydriasis 56.06 11.85 67 62912 6018 29505530
Pleural effusion 55.61 11.85 43 62936 71865 29439683
Cerebrovascular accident 54.56 11.85 50 62929 76861 29434687
Antipsychotic drug level increased 53.93 11.85 49 62930 3194 29508354
Weight decreased 52.83 11.85 156 62823 150749 29360799
Hypotension 52.03 11.85 225 62754 194129 29317419
Asthenia 51.84 11.85 259 62720 214991 29296557
Neuropathy peripheral 51.79 11.85 45 62934 70982 29440566
Anticonvulsant drug level above therapeutic 51.68 11.85 25 62954 549 29510999
Psychomotor retardation 51.53 11.85 46 62933 2930 29508618
Bipolar I disorder 51.12 11.85 27 62952 718 29510830
Hypoplastic left heart syndrome 51.08 11.85 19 62960 210 29511338
Infusion related reaction 51.06 11.85 15 62964 43871 29467677
Excessive eye blinking 51.06 11.85 23 62956 427 29511121
Neutropenia 50.69 11.85 130 62849 131581 29379967
Tubulointerstitial nephritis and uveitis syndrome 50.60 11.85 15 62964 75 29511473
Blister 50.47 11.85 123 62856 19783 29491765
Neonatal behavioural syndrome 49.43 11.85 16 62963 112 29511436
Psychogenic seizure 49.40 11.85 21 62958 337 29511211
Partial seizures with secondary generalisation 49.09 11.85 19 62960 236 29511312
Nausea 49.06 11.85 388 62591 288867 29222681
Apathy 48.91 11.85 63 62916 6108 29505440
Platelet count decreased 48.74 11.85 93 62886 104579 29406969
Peripheral swelling 48.17 11.85 39 62940 63700 29447848
Accidental overdose 48.16 11.85 112 62867 17481 29494067
Erythema multiforme 47.90 11.85 70 62909 7647 29503901
Neuroleptic malignant syndrome 47.76 11.85 106 62873 16042 29495506
Anomaly of external ear congenital 47.36 11.85 15 62964 97 29511451
Thinking abnormal 47.17 11.85 57 62922 5179 29506369
Hypertension 46.50 11.85 113 62866 116501 29395047
Diplopia 46.06 11.85 94 62885 13424 29498124
Therapeutic response unexpected 46.04 11.85 73 62906 8565 29502983
Dystonia 46.03 11.85 78 62901 9671 29501877
Poisoning 45.93 11.85 79 62900 9914 29501634
Hyperkalaemia 45.85 11.85 38 62941 61354 29450194
Overweight 45.76 11.85 32 62947 1426 29510122
Behaviour disorder 45.73 11.85 47 62932 3569 29507979
General physical health deterioration 45.64 11.85 94 62885 102763 29408785
Cleft palate 45.35 11.85 23 62956 561 29510987
Mucosal disorder 44.56 11.85 32 62947 1488 29510060
Strabismus 44.26 11.85 31 62948 1385 29510163
Respiratory failure 43.75 11.85 88 62891 97043 29414505
Learning disorder 43.17 11.85 27 62952 995 29510553
Renal failure 42.66 11.85 121 62858 118478 29393070
Foetal anticonvulsant syndrome 42.37 11.85 28 62951 1136 29510412
Blood prolactin increased 42.03 11.85 31 62948 1503 29510045
Delusion 41.83 11.85 81 62898 11135 29500413
Renal impairment 41.71 11.85 68 62911 81265 29430283
Depression 41.56 11.85 317 62662 84830 29426718
Herpes zoster 41.53 11.85 7 62972 30045 29481503
Dyspnoea exertional 41.50 11.85 13 62966 36477 29475071
Cleft lip and palate 41.45 11.85 18 62961 305 29511243
Retinal pigment epitheliopathy 41.39 11.85 16 62963 198 29511350
Chronic obstructive pulmonary disease 40.85 11.85 18 62961 40937 29470611
Plasma cell myeloma 40.84 11.85 14 62965 37101 29474447
Dyspraxia 40.80 11.85 19 62960 382 29511166
Hypotonia 40.53 11.85 61 62918 6841 29504707
Chest pain 40.44 11.85 114 62865 111859 29399689
Staring 40.35 11.85 29 62950 1350 29510198
Dysarthria 40.26 11.85 151 62828 30760 29480788
Memory impairment 40.13 11.85 169 62810 36301 29475247
Ascites 39.97 11.85 14 62965 36605 29474943
Microcephaly 39.95 11.85 23 62956 727 29510821
Epistaxis 39.86 11.85 31 62948 51673 29459875
Dyskinesia 39.68 11.85 113 62866 19948 29491600
Fatigue 39.64 11.85 458 62521 316363 29195185
Wrong schedule 38.97 11.85 14 62965 139 29511409
Eyelid erosion 38.69 11.85 8 62971 3 29511545
Nasal septum disorder 38.51 11.85 11 62968 47 29511501
Mood altered 38.43 11.85 65 62914 8046 29503502
Decreased appetite 38.41 11.85 169 62810 145173 29366375
Haemorrhage 37.39 11.85 25 62954 45047 29466501
Logorrhoea 36.93 11.85 34 62945 2254 29509294
Depressive symptom 36.80 11.85 30 62949 1687 29509861
Hallucination, auditory 36.66 11.85 70 62909 9523 29502025
Drug titration error 36.25 11.85 18 62961 419 29511129
Chapped lips 35.42 11.85 18 62961 441 29511107
Deep vein thrombosis 35.42 11.85 42 62937 57357 29454191
Tonic clonic movements 35.27 11.85 23 62956 912 29510636
Septic shock 35.27 11.85 49 62930 62511 29449037
Tic 35.06 11.85 30 62949 1805 29509743
Coarctation of the aorta 35.05 11.85 18 62961 451 29511097
Arthropathy 34.73 11.85 3 62976 21551 29489997
Rash erythematous 34.72 11.85 113 62866 21449 29490099
Motor developmental delay 34.52 11.85 20 62959 640 29510908
Congenital diaphragmatic hernia 34.50 11.85 15 62964 255 29511293
Psychomotor skills impaired 34.40 11.85 35 62944 2626 29508922
Anticonvulsant drug level increased 34.38 11.85 27 62952 1439 29510109
Body dysmorphic disorder 34.35 11.85 12 62967 109 29511439
Cardiac septal hypertrophy 34.08 11.85 15 62964 263 29511285
Pulmonary hypoplasia 33.73 11.85 17 62962 409 29511139
Pneumonitis 33.71 11.85 9 62970 28035 29483513
Abulia 33.60 11.85 18 62961 493 29511055
Chills 33.48 11.85 63 62916 71237 29440311
Anticonvulsant drug level decreased 33.47 11.85 23 62956 996 29510552
Polydactyly 33.42 11.85 24 62955 1116 29510432
Educational problem 33.08 11.85 18 62961 509 29511039
Parasomnia 33.01 11.85 16 62963 353 29511195
Paranoia 32.84 11.85 68 62911 9809 29501739
Postictal paralysis 32.69 11.85 14 62965 229 29511319
Suspiciousness 32.65 11.85 15 62964 292 29511256
Atonic seizures 32.65 11.85 13 62966 175 29511373
Rash morbilliform 32.61 11.85 33 62946 2460 29509088
Productive cough 32.36 11.85 13 62966 31246 29480302
Abdominal pain upper 32.20 11.85 50 62929 60943 29450605
Face oedema 32.11 11.85 69 62910 10214 29501334
Burnout syndrome 31.99 11.85 12 62967 136 29511412
Dysmetria 31.71 11.85 16 62963 386 29511162
Rectal haemorrhage 31.69 11.85 17 62962 34532 29477016
Angina pectoris 31.53 11.85 10 62969 27840 29483708
Personality disorder 31.46 11.85 23 62956 1100 29510448
Erythema of eyelid 31.41 11.85 19 62960 659 29510889
Catatonia 31.38 11.85 43 62936 4425 29507123
Haematochezia 31.37 11.85 20 62959 36963 29474585
Eye discharge 31.21 11.85 27 62952 1649 29509899
Limb reduction defect 31.07 11.85 14 62965 260 29511288
Depressed level of consciousness 30.90 11.85 158 62821 36784 29474764
Sinus tachycardia 30.89 11.85 86 62893 14983 29496565
Illusion 30.80 11.85 19 62960 683 29510865
Neonatal respiratory arrest 30.71 11.85 8 62971 22 29511526
Blood creatine phosphokinase increased 30.69 11.85 169 62810 40475 29471073
Retrognathia 30.69 11.85 14 62965 268 29511280
Angular cheilitis 30.65 11.85 12 62967 154 29511394
Anticonvulsant drug level below therapeutic 30.13 11.85 18 62961 610 29510938
Arthritis 30.13 11.85 8 62971 25011 29486537
Epidermal necrosis 29.77 11.85 16 62963 441 29511107
Haematuria 29.77 11.85 30 62949 44109 29467439
Cryptorchism 29.69 11.85 28 62951 1914 29509634
Hypernatraemia 29.59 11.85 55 62924 7331 29504217
Respiratory acidosis 29.42 11.85 41 62938 4287 29507261
Anxiety 29.23 11.85 294 62685 85071 29426477
Prostate cancer 29.19 11.85 9 62970 25518 29486030
Speech disorder 29.07 11.85 113 62866 23403 29488145
Encephalopathy 28.98 11.85 137 62842 30906 29480642
Suspected suicide 28.71 11.85 39 62940 3981 29507567
Temperature regulation disorder 28.65 11.85 17 62962 569 29510979
Mucosal erosion 28.57 11.85 18 62961 672 29510876
Delirium 28.54 11.85 162 62817 39235 29472313
Syncope 28.52 11.85 84 62895 81287 29430261
Haemangioma congenital 28.45 11.85 16 62963 483 29511065
Musculoskeletal pain 28.44 11.85 13 62966 28940 29482608
Skin erosion 28.42 11.85 26 62953 1710 29509838
Upper gastrointestinal haemorrhage 28.37 11.85 6 62973 21908 29489640
Convulsive threshold lowered 28.34 11.85 16 62963 487 29511061
Drug level decreased 28.20 11.85 49 62930 6198 29505350
Off label use 28.17 11.85 461 62518 300339 29211209
Eosinophil percentage increased 28.07 11.85 16 62963 496 29511052
Developmental regression 28.04 11.85 8 62971 34 29511514
Drug resistance 27.85 11.85 105 62874 21435 29490113
Lung disorder 27.76 11.85 15 62964 30347 29481201
Insomnia 27.70 11.85 300 62679 88461 29423087
Lymphadenopathy 27.49 11.85 116 62863 24933 29486615
Cerebral ventricle dilatation 27.48 11.85 19 62960 831 29510717
Bicuspid aortic valve 27.44 11.85 12 62967 207 29511341
Enanthema 27.40 11.85 14 62965 347 29511201
Affect lability 27.38 11.85 35 62944 3367 29508181
Cytomegalovirus infection 26.88 11.85 8 62971 23207 29488341
Renal aplasia 26.65 11.85 17 62962 649 29510899
Haemoptysis 26.63 11.85 16 62963 30534 29481014
Hypoglycaemia neonatal 26.63 11.85 25 62954 1699 29509849
Tongue movement disturbance 26.55 11.85 9 62970 74 29511474
Pilonidal cyst congenital 26.42 11.85 7 62972 21 29511527
Derealisation 26.25 11.85 16 62963 563 29510985
Suicide threat 26.18 11.85 7 62972 22 29511526
Caesarean section 26.16 11.85 26 62953 1897 29509651
Cleft lip 25.78 11.85 13 62966 313 29511235
Plagiocephaly 25.69 11.85 15 62964 487 29511061
Pulmonary oedema 25.59 11.85 32 62947 42703 29468845
Peripheral circulatory failure 25.57 11.85 10 62969 128 29511420
Intentional product use issue 25.26 11.85 32 62947 42466 29469082
Nasopharyngitis 25.22 11.85 56 62923 59609 29451939
Apnoea 25.15 11.85 46 62933 6056 29505492
Myoclonic epilepsy 25.14 11.85 19 62960 956 29510592
Colitis 25.03 11.85 18 62961 31230 29480318
Cataplexy 24.95 11.85 12 62967 260 29511288
Pancytopenia 24.91 11.85 92 62887 83076 29428472
Mental disorder 24.85 11.85 72 62907 12833 29498715
Madarosis 24.78 11.85 11 62968 197 29511351
Erythema 24.73 11.85 258 62721 75348 29436200
Intellectual disability 24.65 11.85 20 62959 1117 29510431
Movement disorder 24.62 11.85 62 62917 10175 29501373
Thrombocytopenia 24.59 11.85 177 62802 134646 29376902
Blood pressure increased 24.57 11.85 78 62901 73725 29437823
Hyperhomocysteinaemia 24.48 11.85 11 62968 203 29511345
Large for dates baby 24.47 11.85 18 62961 869 29510679
Irregular sleep phase 24.36 11.85 8 62971 59 29511489
Hyperexplexia 24.30 11.85 7 62972 31 29511517
Hypomagnesaemia 24.29 11.85 4 62975 17464 29494084
Drooling 24.19 11.85 31 62948 2990 29508558
Altered state of consciousness 24.12 11.85 95 62884 19794 29491754
Major depression 24.11 11.85 35 62944 3800 29507748
Altered pitch perception 24.04 11.85 6 62973 13 29511535
Epispadias 23.84 11.85 10 62969 155 29511393
COVID-19 23.69 11.85 25 62954 35989 29475559
Congenital melanocytic naevus 23.44 11.85 6 62973 15 29511533
Gout 23.23 11.85 4 62975 16907 29494641
Heart rate decreased 23.23 11.85 12 62967 24900 29486648
Disturbance in social behaviour 23.13 11.85 23 62956 1679 29509869
Chest discomfort 23.05 11.85 39 62940 45944 29465604
Pulmonary fibrosis 22.98 11.85 3 62976 15579 29495969
Confusional state 22.87 11.85 391 62588 127486 29384062
Change in seizure presentation 22.87 11.85 8 62971 73 29511475
Cerebral infarction 22.84 11.85 12 62967 24663 29486885
International normalised ratio increased 22.83 11.85 37 62942 44335 29467213
Distributive shock 22.79 11.85 18 62961 967 29510581
Cheilitis 22.74 11.85 25 62954 2051 29509497
Gambling disorder 22.74 11.85 22 62957 1553 29509995
Developmental coordination disorder 22.74 11.85 10 62969 175 29511373
Ear disorder 22.67 11.85 20 62959 1254 29510294
Papule 22.57 11.85 31 62948 3198 29508350
Neurological decompensation 22.50 11.85 27 62952 2435 29509113
Osteonecrosis of jaw 22.47 11.85 4 62975 16506 29495042
Gait disturbance 22.46 11.85 247 62732 73102 29438446
Transferrin increased 22.32 11.85 5 62974 5 29511543
Salivary hypersecretion 22.32 11.85 49 62930 7360 29504188
Pyramidal tract syndrome 22.08 11.85 10 62969 188 29511360
Spina bifida 21.97 11.85 12 62967 342 29511206
Blood creatinine increased 21.82 11.85 100 62879 85002 29426546
Intelligence test abnormal 21.73 11.85 6 62973 22 29511526
Cardio-respiratory arrest 21.72 11.85 183 62796 50418 29461130
Congenital eyelid malformation 21.63 11.85 7 62972 49 29511499
Cerebral haemorrhage 21.60 11.85 21 62958 31405 29480143
Muscle rigidity 21.60 11.85 56 62923 9355 29502193
Schizophrenia 21.59 11.85 45 62934 6520 29505028
Exposure via ingestion 21.58 11.85 24 62955 1994 29509554
Influenza 21.47 11.85 35 62944 41846 29469702
Congenital genital malformation male 21.41 11.85 5 62974 7 29511541
Emotional disorder 21.38 11.85 38 62941 4893 29506655
Hypertonia 21.29 11.85 33 62946 3796 29507752
Psoriatic arthropathy 21.26 11.85 3 62976 14688 29496860
Melaena 21.23 11.85 21 62958 31155 29480393
Depersonalisation/derealisation disorder 21.21 11.85 14 62965 567 29510981
Cardiac disorder 21.18 11.85 29 62950 37234 29474314
Congenital astigmatism 21.12 11.85 6 62973 25 29511523
Distractibility 20.88 11.85 11 62968 291 29511257
Myalgia 20.80 11.85 84 62895 73935 29437613
Compulsive shopping 20.77 11.85 12 62967 382 29511166
Ocular hyperaemia 20.63 11.85 54 62925 9073 29502475
Scab 20.62 11.85 33 62946 3901 29507647
Skin malformation 20.62 11.85 4 62975 0 29511548
Mucosal exfoliation 20.62 11.85 4 62975 0 29511548
Lung neoplasm malignant 20.62 11.85 3 62976 14354 29497194
Mental impairment 20.57 11.85 54 62925 9087 29502461
Laryngomalacia 20.51 11.85 11 62968 302 29511246
Skin exfoliation 20.45 11.85 99 62880 22546 29489002
Language disorder 20.44 11.85 23 62956 1936 29509612
Postictal state 20.38 11.85 15 62964 725 29510823
Aphasia 20.36 11.85 88 62891 19110 29492438
Hyperbilirubinaemia neonatal 20.34 11.85 15 62964 727 29510821
Constipation 20.26 11.85 151 62828 114009 29397539
Drug withdrawal convulsions 20.21 11.85 18 62961 1143 29510405
Hyperglycaemia 20.19 11.85 26 62953 34261 29477287
Oral disorder 20.14 11.85 32 62947 3761 29507787
Hallucination, visual 20.08 11.85 74 62905 14941 29496607
Bacteraemia 20.07 11.85 5 62974 16318 29495230
Dyslexia 19.90 11.85 11 62968 321 29511227
Opsoclonus myoclonus 19.81 11.85 7 62972 66 29511482
Wheezing 19.78 11.85 25 62954 33215 29478333
Wrong product administered 19.75 11.85 35 62944 4496 29507052
Product dispensing error 19.73 11.85 39 62940 5441 29506107
Muscle twitching 19.71 11.85 49 62930 7977 29503571
Restless legs syndrome 19.70 11.85 45 62934 6939 29504609
Subgaleal haematoma 19.61 11.85 6 62973 34 29511514
Mucosal inflammation 19.61 11.85 23 62956 31572 29479976
Brain malformation 19.55 11.85 8 62971 116 29511432
Aplasia cutis congenita 19.49 11.85 8 62971 117 29511431
Blood pressure fluctuation 19.43 11.85 9 62970 19885 29491663
Peritonitis 19.31 11.85 4 62975 14820 29496728
Increased appetite 19.29 11.85 41 62938 6023 29505525
Bone marrow failure 19.26 11.85 18 62961 27431 29484117
Sinusitis 19.26 11.85 27 62952 34323 29477225
Feelings of worthlessness 19.24 11.85 10 62969 257 29511291
Disorientation 19.20 11.85 118 62861 29397 29482151
Blood glucose increased 19.17 11.85 63 62916 58921 29452627
Coordination abnormal 19.15 11.85 45 62934 7069 29504479
Potter's syndrome 19.13 11.85 5 62974 14 29511534
Epileptic aura 19.13 11.85 5 62974 14 29511534
Congenital cerebral cyst 19.13 11.85 5 62974 14 29511534
Transaminases increased 19.00 11.85 97 62882 22565 29488983
Blood potassium increased 18.99 11.85 4 62975 14647 29496901
Diverticulitis 18.92 11.85 7 62972 17697 29493851
Impulsive behaviour 18.90 11.85 22 62957 1921 29509627
Gangrene neonatal 18.84 11.85 9 62970 192 29511356
Neoplasm progression 18.84 11.85 8 62971 18604 29492944
Congenital hand malformation 18.82 11.85 13 62966 568 29510980
Persecutory delusion 18.78 11.85 23 62956 2118 29509430
Transverse presentation 18.61 11.85 7 62972 80 29511468
Hepatic cirrhosis 18.61 11.85 4 62975 14440 29497108
Anal atresia 18.53 11.85 10 62969 278 29511270
Developmental hip dysplasia 18.43 11.85 10 62969 281 29511267
Cerebellar atrophy 18.40 11.85 12 62967 476 29511072
Product use in unapproved indication 18.38 11.85 109 62870 86766 29424782
Tongue eruption 18.38 11.85 4 62975 3 29511545
Snoring 18.37 11.85 26 62953 2758 29508790
Fluid retention 18.31 11.85 14 62965 23546 29488002
Tongue biting 18.28 11.85 14 62965 719 29510829
Cardiogenic shock 18.26 11.85 9 62970 19181 29492367
Single umbilical artery 18.19 11.85 9 62970 208 29511340
Skin degenerative disorder 18.18 11.85 5 62974 18 29511530
Joint laxity 18.10 11.85 11 62968 385 29511163
Genital erosion 18.03 11.85 9 62970 212 29511336
Obsessive thoughts 18.02 11.85 13 62966 609 29510939
Hypoxia 18.01 11.85 47 62932 47332 29464216
Urinary tract infection 17.97 11.85 86 62893 72268 29439280
Teratogenicity 17.95 11.85 6 62973 47 29511501
Blood urea increased 17.95 11.85 20 62959 28092 29483456
Treatment noncompliance 17.79 11.85 100 62879 24127 29487421
Vesicoureteric reflux 17.74 11.85 8 62971 149 29511399
Myocardial ischaemia 17.71 11.85 6 62973 16022 29495526
Full blood count decreased 17.64 11.85 6 62973 15986 29495562
Muscle tone disorder 17.64 11.85 8 62971 151 29511397
Wrong patient received product 17.62 11.85 23 62956 2259 29509289
Bundle branch block right 17.55 11.85 42 62937 6675 29504873
Congenital genital malformation 17.53 11.85 7 62972 95 29511453
Dehydration 17.52 11.85 158 62821 114590 29396958
Affective disorder 17.47 11.85 27 62952 3099 29508449
Hypokalaemia 17.45 11.85 52 62927 50151 29461397
Akathisia 17.45 11.85 42 62937 6700 29504848
Localised infection 17.45 11.85 4 62975 13812 29497736
Parkinsonism 17.42 11.85 44 62935 7234 29504314
Mouth ulceration 17.33 11.85 55 62924 10300 29501248
Pneumocystis jirovecii pneumonia 17.33 11.85 7 62972 16772 29494776
Posture abnormal 17.22 11.85 21 62958 1926 29509622
Weight decrease neonatal 17.17 11.85 10 62969 323 29511225
Neonatal disorder 17.15 11.85 14 62965 789 29510759
Psychiatric symptom 17.09 11.85 27 62952 3157 29508391
Feeling jittery 17.06 11.85 29 62950 3604 29507944
Cross sensitivity reaction 17.05 11.85 17 62962 1245 29510303
Bone pain 17.04 11.85 9 62970 18443 29493105
Oculomucocutaneous syndrome 16.99 11.85 8 62971 165 29511383
Hyperreflexia 16.99 11.85 25 62954 2747 29508801
Intraventricular haemorrhage neonatal 16.98 11.85 9 62970 241 29511307
Drug screen false positive 16.98 11.85 13 62966 667 29510881
Differential white blood cell count abnormal 16.97 11.85 17 62962 1252 29510296
SJS-TEN overlap 16.91 11.85 9 62970 243 29511305
Meningeal disorder 16.90 11.85 10 62969 333 29511215
Newborn persistent pulmonary hypertension 16.89 11.85 7 62972 105 29511443
Serotonin syndrome 16.86 11.85 78 62901 17434 29494114
Renal disorder 16.84 11.85 14 62965 22581 29488967
Nasal disorder 16.83 11.85 18 62961 1431 29510117
Acute coronary syndrome 16.74 11.85 3 62976 12322 29499226
Eyelid oedema 16.70 11.85 33 62946 4603 29506945
Congenital central nervous system anomaly 16.69 11.85 11 62968 444 29511104
Cerebellar syndrome 16.65 11.85 21 62958 1993 29509555
Hypermobility syndrome 16.50 11.85 10 62969 348 29511200
Chordee 16.49 11.85 6 62973 62 29511486
Mood swings 16.49 11.85 43 62936 7208 29504340
Feeling drunk 16.45 11.85 19 62960 1645 29509903
Dysgraphia 16.45 11.85 21 62958 2017 29509531
Sopor 16.44 11.85 56 62923 10878 29500670
Foetal distress syndrome 16.43 11.85 15 62964 984 29510564
Chronic kidney disease 16.37 11.85 33 62946 36383 29475165
Kidney malformation 16.36 11.85 8 62971 180 29511368
Clostridium difficile colitis 16.34 11.85 4 62975 13208 29498340
Subacute cutaneous lupus erythematosus 16.32 11.85 14 62965 845 29510703
Withdrawal syndrome 16.26 11.85 56 62923 10936 29500612
Positive end-expiratory pressure 16.24 11.85 4 62975 8 29511540
Clostridium difficile infection 16.24 11.85 7 62972 16134 29495414
Fallot's tetralogy 16.24 11.85 8 62971 183 29511365
Rash macular 16.21 11.85 54 62925 10371 29501177
Product name confusion 16.16 11.85 6 62973 66 29511482
Oesophagitis 15.99 11.85 3 62976 11920 29499628
Thrombocytopenia neonatal 15.98 11.85 10 62969 369 29511179
Suicidal behaviour 15.93 11.85 17 62962 1348 29510200
Blood pressure systolic increased 15.87 11.85 8 62971 16837 29494711
Extrapyramidal disorder 15.87 11.85 55 62924 10776 29500772
Metastases to liver 15.86 11.85 3 62976 11853 29499695
Abdominal discomfort 15.68 11.85 51 62928 47852 29463696
Lethargy 15.64 11.85 135 62844 37445 29474103
Deja vu 15.63 11.85 4 62975 10 29511538
Dyspepsia 15.60 11.85 25 62954 30100 29481448
Hypercalcaemia 15.51 11.85 4 62975 12755 29498793
Drug intolerance 15.49 11.85 52 62927 48327 29463221
Circadian rhythm sleep disorder 15.48 11.85 10 62969 390 29511158
Hyperphagia 15.47 11.85 16 62963 1224 29510324
Rubella 15.46 11.85 3 62976 0 29511548
Metabolic myopathy 15.46 11.85 3 62976 0 29511548
Encephalocele 15.46 11.85 3 62976 0 29511548
Hypoglycaemia 15.46 11.85 52 62927 48294 29463254
Pulmonary valve stenosis congenital 15.44 11.85 7 62972 132 29511416
Respiratory arrest 15.39 11.85 101 62878 25732 29485816
Hyperkinesia 15.38 11.85 18 62961 1581 29509967
Dermatitis allergic 15.33 11.85 36 62943 5652 29505896
Cataract 15.32 11.85 15 62964 22363 29489185
Tonic convulsion 15.29 11.85 14 62965 922 29510626
Asterixis 15.25 11.85 15 62964 1080 29510468
Torticollis 15.25 11.85 15 62964 1080 29510468
Economic problem 15.25 11.85 16 62963 1244 29510304
Lip oedema 15.16 11.85 21 62958 2183 29509365
Prostatic specific antigen increased 15.16 11.85 4 62975 12560 29498988
Anaphylactic reaction 15.13 11.85 22 62957 27551 29483997
Congenital scoliosis 15.12 11.85 6 62973 80 29511468
Monorchidism 15.10 11.85 4 62975 12 29511536
Skin turgor decreased 15.02 11.85 10 62969 411 29511137
Congenital vas deferens absence 14.98 11.85 5 62974 39 29511509
Congenital muscle absence 14.98 11.85 5 62974 39 29511509
Abdominal distension 14.94 11.85 49 62930 45862 29465686
Sleep disorder 14.93 11.85 96 62883 24290 29487258
Injection site pain 14.93 11.85 29 62950 32417 29479131
Arthropod sting 14.88 11.85 9 62970 312 29511236
Cellulitis 14.86 11.85 49 62930 45791 29465757
Rash papular 14.86 11.85 44 62935 7937 29503611
Postmature baby 14.86 11.85 4 62975 13 29511535
Lactic acidosis 14.84 11.85 26 62953 30221 29481327
Candida infection 14.70 11.85 7 62972 15218 29496330
Cerebral atrophy 14.69 11.85 29 62950 4043 29507505
Thrombosis 14.67 11.85 45 62934 43000 29468548
Hypertelorism 14.65 11.85 11 62968 548 29511000
Drop attacks 14.65 11.85 11 62968 548 29511000
Neoplasm malignant 14.56 11.85 9 62970 16916 29494632
Acute respiratory failure 14.55 11.85 21 62958 26381 29485167
Enuresis 14.55 11.85 20 62959 2064 29509484
Hypothermia neonatal 14.54 11.85 6 62973 89 29511459
Pulmonary hypertension 14.54 11.85 11 62968 18597 29492951
Agoraphobia 14.46 11.85 8 62971 234 29511314
Idiopathic generalised epilepsy 14.45 11.85 5 62974 44 29511504
Congenital inguinal hernia 14.38 11.85 7 62972 156 29511392
Cytokine release syndrome 14.34 11.85 5 62974 13114 29498434
Delusional perception 14.30 11.85 7 62972 158 29511390
Exomphalos 14.30 11.85 7 62972 158 29511390
Peripheral artery thrombosis 14.27 11.85 20 62959 2102 29509446
Conversion disorder 14.19 11.85 9 62970 340 29511208
Judgement impaired 14.09 11.85 11 62968 581 29510967
Automatism 14.02 11.85 6 62973 98 29511450
Angina unstable 14.01 11.85 3 62976 10862 29500686
Limited symptom panic attack 13.98 11.85 5 62974 49 29511499
Prominent epicanthal folds 13.90 11.85 7 62972 168 29511380
Laboratory test abnormal 13.89 11.85 11 62968 18174 29493374
Tooth malformation 13.87 11.85 7 62972 169 29511379
Caudal regression syndrome 13.80 11.85 5 62974 51 29511497
Temporal lobe epilepsy 13.79 11.85 7 62972 171 29511377
Transient tachypnoea of the newborn 13.79 11.85 7 62972 171 29511377
Moaning 13.79 11.85 12 62967 739 29510809
Sweat gland disorder 13.75 11.85 6 62973 103 29511445
Conjunctival irritation 13.75 11.85 6 62973 103 29511445
Psychotic symptom 13.74 11.85 16 62963 1398 29510150
Loss of employment 13.70 11.85 10 62969 477 29511071
Hospitalisation 13.67 11.85 51 62928 45937 29465611
Hypothermia 13.61 11.85 47 62932 9192 29502356
Epidermolysis 13.58 11.85 8 62971 264 29511284
Muscle spasms 13.58 11.85 82 62897 65000 29446548
Somnolence neonatal 13.49 11.85 4 62975 20 29511528
Double outlet right ventricle 13.49 11.85 6 62973 108 29511440
Aspergillus infection 13.49 11.85 3 62976 10578 29500970
Hepatotoxicity 13.40 11.85 11 62968 17856 29493692
Trichiasis 13.39 11.85 3 62976 3 29511545
Congenital knee deformity 13.34 11.85 6 62973 111 29511437
Heart disease congenital 13.31 11.85 15 62964 1265 29510283
Visual field defect 13.29 11.85 28 62951 4088 29507460
Grimacing 13.26 11.85 8 62971 276 29511272
Pollakiuria 13.21 11.85 10 62969 16906 29494642
Renal tubular necrosis 13.19 11.85 7 62972 14308 29497240
Oral mucosal erythema 13.15 11.85 9 62970 387 29511161
Abortion induced 13.05 11.85 6 62973 117 29511431
Multiple congenital abnormalities 13.05 11.85 10 62969 514 29511034
Dysphoria 13.02 11.85 19 62960 2073 29509475
Hyperpyrexia 12.97 11.85 20 62959 2290 29509258
Bronchiolitis 12.95 11.85 22 62957 2733 29508815
Symblepharon 12.91 11.85 6 62973 120 29511428
Nephritis allergic 12.89 11.85 9 62970 400 29511148
Conjunctival scar 12.85 11.85 5 62974 63 29511485
Terminal insomnia 12.83 11.85 9 62970 403 29511145
Congenital myopia 12.78 11.85 5 62974 64 29511484
Gastric ulcer 12.77 11.85 7 62972 14054 29497494
Congenital aortic atresia 12.75 11.85 4 62975 25 29511523
Erythema annulare 12.75 11.85 4 62975 25 29511523
Swelling 12.66 11.85 36 62943 35247 29476301
Coronary artery occlusion 12.59 11.85 3 62976 10091 29501457
Blunted affect 12.57 11.85 8 62971 304 29511244
Osteoarthritis 12.55 11.85 12 62967 18091 29493457
Delusion of grandeur 12.54 11.85 9 62970 418 29511130
Crystal urine present 12.50 11.85 9 62970 420 29511128
Learning disability 12.43 11.85 8 62971 310 29511238
Strabismus congenital 12.36 11.85 4 62975 28 29511520
Low set ears 12.35 11.85 9 62970 428 29511120
Mental status changes 12.28 11.85 121 62858 34806 29476742
Pleurothotonus 12.24 11.85 13 62966 1025 29510523
Meconium in amniotic fluid 12.24 11.85 4 62975 29 29511519
Dyscalculia 12.24 11.85 4 62975 29 29511519
Ligament laxity 12.24 11.85 4 62975 29 29511519
Cholelithiasis 12.23 11.85 13 62966 18659 29492889
Viral rash 12.19 11.85 5 62974 73 29511475
Muscle spasticity 12.19 11.85 30 62949 4853 29506695
Essential tremor 12.18 11.85 11 62968 711 29510837
Aortic valve atresia 12.18 11.85 3 62976 6 29511542
Assisted delivery 12.18 11.85 3 62976 6 29511542
Human herpesvirus 7 infection 12.18 11.85 3 62976 6 29511542
Small fontanelle 12.18 11.85 3 62976 6 29511542
Congenital spinal cord anomaly 12.18 11.85 3 62976 6 29511542
Defect conduction intraventricular 12.05 11.85 7 62972 225 29511323
Poisoning deliberate 12.03 11.85 33 62946 5698 29505850
Agitated depression 12.00 11.85 7 62972 227 29511321
Impaired healing 11.96 11.85 7 62972 13551 29497997
Product quality issue 11.93 11.85 66 62913 15829 29495719
Hypoaesthesia 11.89 11.85 66 62913 53401 29458147
Jaundice neonatal 11.85 11.85 14 62965 1242 29510306

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2564.64 11.09 2426 137598 164466 64194242
Drug reaction with eosinophilia and systemic symptoms 1971.82 11.09 1311 138713 52906 64305802
Completed suicide 1871.28 11.09 2365 137659 222049 64136659
Stevens-Johnson syndrome 1544.80 11.09 949 139075 33300 64325408
Toxicity to various agents 1297.32 11.09 2597 137427 360916 63997792
Generalised tonic-clonic seizure 1014.53 11.09 776 139248 39081 64319627
Intentional overdose 900.71 11.09 1042 138982 88902 64269806
Toxic epidermal necrolysis 685.47 11.09 600 139424 36566 64322142
Epilepsy 685.00 11.09 574 139450 32957 64325751
Suicide attempt 630.48 11.09 774 139250 70233 64288475
Status epilepticus 618.45 11.09 452 139572 21211 64337497
Ataxia 588.31 11.09 442 139582 21642 64337066
Product substitution issue 542.56 11.09 387 139637 17474 64341234
Aggression 507.27 11.09 562 139462 45670 64313038
Drug interaction 495.36 11.09 1817 138207 360266 63998442
Exposure during pregnancy 481.79 11.09 711 139313 76964 64281744
Overdose 449.25 11.09 1038 138986 158528 64200180
Somnolence 428.43 11.09 1186 138838 202459 64156249
Agitation 405.36 11.09 705 139319 87662 64271046
Intentional self-injury 387.74 11.09 392 139632 28652 64330056
Rash 365.99 11.09 1959 138065 456590 63902118
Nystagmus 355.22 11.09 230 139794 8838 64349870
Rash maculo-papular 347.15 11.09 468 139556 46558 64312150
Dyspnoea 340.54 11.09 654 139370 718020 63640688
Diarrhoea 336.08 11.09 665 139359 722039 63636669
Suicidal ideation 322.35 11.09 544 139480 65998 64292710
Petit mal epilepsy 310.38 11.09 171 139853 4861 64353847
Pneumonia 305.29 11.09 465 139559 559111 63799597
Mania 292.30 11.09 259 139765 16027 64342681
Coma 276.65 11.09 597 139427 87018 64271690
Irritability 276.23 11.09 369 139655 36377 64322331
Arthralgia 263.37 11.09 345 139679 441915 63916793
Lymphadenopathy 248.07 11.09 398 139626 46288 64312420
Partial seizures 246.78 11.09 169 139855 7138 64351570
Rheumatoid arthritis 238.48 11.09 36 139988 164258 64194450
Tremor 235.81 11.09 783 139241 147447 64211261
Febrile neutropenia 232.90 11.09 60 139964 187597 64171111
Focal dyscognitive seizures 231.42 11.09 122 139902 3168 64355540
Anaemia 230.94 11.09 290 139734 378390 63980318
Infusion related reaction 225.52 11.09 42 139982 164425 64194283
Joint swelling 223.28 11.09 94 139930 215288 64143420
Serotonin syndrome 219.90 11.09 343 139681 38939 64319769
Sudden unexplained death in epilepsy 219.30 11.09 73 139951 552 64358156
Abnormal behaviour 217.34 11.09 314 139710 33308 64325400
Oral mucosa erosion 216.91 11.09 95 139929 1612 64357096
Pain 215.56 11.09 560 139464 552951 63805757
Drug eruption 212.77 11.09 323 139701 35813 64322895
Haemophagocytic lymphohistiocytosis 210.40 11.09 224 139800 17385 64341323
Diplopia 206.11 11.09 272 139752 26493 64332215
Obsessive-compulsive disorder 200.58 11.09 127 139897 4691 64354017
Electrocardiogram QRS complex prolonged 194.38 11.09 161 139863 9083 64349625
Synovitis 191.47 11.09 5 140019 99085 64259623
Peripheral swelling 191.39 11.09 108 139916 209045 64149663
Arthropathy 191.33 11.09 20 140004 120947 64237761
Abortion spontaneous 191.27 11.09 254 139770 24889 64333819
Acute kidney injury 186.89 11.09 439 139585 448801 63909907
Drug level increased 182.30 11.09 292 139732 33904 64324804
Contraindicated product administered 180.83 11.09 14 140010 107815 64250893
Myoclonus 180.79 11.09 247 139777 24871 64333837
Poisoning 180.42 11.09 230 139794 21649 64337059
Pain in extremity 175.55 11.09 241 139783 302844 64055864
Atrial fibrillation 168.91 11.09 80 139944 171009 64187699
Lip erosion 168.45 11.09 73 139951 1206 64357502
Cardiac failure congestive 167.34 11.09 39 139985 130541 64228167
Cognitive disorder 164.32 11.09 367 139657 54720 64303988
Anticonvulsant drug level decreased 164.20 11.09 80 139944 1750 64356958
Multiple-drug resistance 159.61 11.09 124 139900 6378 64352330
Nasopharyngitis 157.90 11.09 117 139907 195956 64162752
Disturbance in attention 154.52 11.09 301 139723 40773 64317935
Erythema multiforme 153.69 11.09 180 139844 15521 64343187
Conjunctival hyperaemia 152.96 11.09 99 139925 3800 64354908
Psychotic disorder 150.81 11.09 270 139754 34308 64324400
Myocardial infarction 148.29 11.09 88 139936 165733 64192975
Oculogyric crisis 147.65 11.09 83 139941 2455 64356253
Malignant neoplasm progression 146.04 11.09 33 139991 112838 64245870
Anticonvulsant drug level above therapeutic 139.63 11.09 60 139964 970 64357738
Tardive dyskinesia 139.45 11.09 133 139891 9045 64349663
Depression 138.72 11.09 773 139251 182518 64176190
Disease progression 138.68 11.09 67 139957 141613 64217095
Cough 138.09 11.09 280 139744 301868 64056840
Aura 136.33 11.09 56 139968 804 64357904
Foetal exposure during pregnancy 135.92 11.09 97 139927 4379 64354329
Hyperreflexia 134.92 11.09 117 139907 7031 64351677
Rash morbilliform 134.87 11.09 102 139922 5039 64353669
Electroencephalogram abnormal 133.78 11.09 102 139922 5101 64353607
Anxiety 132.30 11.09 822 139202 201827 64156881
Brugada syndrome 130.54 11.09 58 139966 1020 64357688
Hypomania 128.41 11.09 103 139921 5551 64353157
Anticonvulsant drug level increased 128.24 11.09 74 139950 2303 64356405
Gastrointestinal haemorrhage 127.33 11.09 64 139960 132248 64226460
Face oedema 125.93 11.09 207 139817 24554 64334154
Neuroleptic malignant syndrome 125.83 11.09 208 139816 24788 64333920
Bipolar disorder 124.26 11.09 109 139915 6652 64352056
Cardio-respiratory arrest 123.31 11.09 481 139543 97912 64260796
Back pain 122.87 11.09 222 139802 249949 64108759
Myoclonic epilepsy 122.76 11.09 63 139961 1545 64357163
Sinusitis 120.17 11.09 85 139939 145843 64212865
Infection 119.52 11.09 135 139889 184745 64173963
Muscle rigidity 118.52 11.09 167 139857 17306 64341402
Extrapyramidal disorder 118.25 11.09 177 139847 19375 64339333
Psychomotor hyperactivity 117.70 11.09 151 139873 14300 64344408
Accidental exposure to product by child 117.39 11.09 71 139953 2414 64356294
Cardiac failure 117.28 11.09 71 139953 132302 64226406
Depressed level of consciousness 116.97 11.09 416 139608 81020 64277688
Clonus 113.89 11.09 99 139925 5968 64352740
Swelling 111.39 11.09 110 139914 160108 64198600
Suspected suicide 110.36 11.09 114 139910 8540 64350168
Bipolar I disorder 108.71 11.09 60 139964 1711 64356997
Sepsis 107.29 11.09 211 139813 230130 64128578
Death 105.31 11.09 616 139408 482089 63876619
Pleurothotonus 104.21 11.09 64 139960 2238 64356470
Coronary artery disease 103.74 11.09 7 140017 60426 64298282
Hyperkalaemia 103.34 11.09 45 139979 101084 64257624
Hypertension 103.15 11.09 259 139765 259002 64099706
Abdominal discomfort 101.46 11.09 149 139875 182173 64176535
Mood altered 101.45 11.09 148 139876 15831 64342877
Haemoglobin decreased 100.39 11.09 168 139856 194895 64163813
Vertigo 99.35 11.09 318 139706 58693 64300015
Meningitis aseptic 98.59 11.09 89 139935 5641 64353067
Neuropathy peripheral 97.35 11.09 68 139956 117457 64241251
Anger 97.34 11.09 144 139880 15597 64343111
Blood pressure increased 97.01 11.09 140 139884 172412 64186296
Lower respiratory tract infection 96.83 11.09 42 139982 94572 64264136
Balance disorder 96.13 11.09 399 139625 83527 64275181
Chest pain 96.01 11.09 233 139791 235747 64122961
Cross sensitivity reaction 95.48 11.09 70 139954 3297 64355411
Drug level decreased 94.95 11.09 121 139903 11382 64347326
Abortion induced 94.09 11.09 91 139933 6297 64352411
Suicidal behaviour 93.32 11.09 65 139959 2822 64355886
Herpes zoster 93.17 11.09 28 139996 79159 64279549
Hallucination, auditory 92.12 11.09 146 139878 16793 64341915
Depressed mood 91.11 11.09 244 139780 40768 64317940
Atonic seizures 91.01 11.09 39 139985 626 64358082
Fatigue 89.98 11.09 1118 138906 747612 63611096
Delusion 89.46 11.09 149 139875 17865 64340843
Mydriasis 88.88 11.09 136 139888 15176 64343532
Rash erythematous 88.26 11.09 269 139755 48364 64310344
Eosinophilia 87.08 11.09 229 139795 37847 64320861
Conjunctivitis 86.28 11.09 157 139867 20197 64338511
Cerebrovascular accident 86.16 11.09 103 139921 137480 64221228
Drug intolerance 85.98 11.09 174 139850 187818 64170890
Hyperthermia 85.91 11.09 135 139889 15415 64343293
Restlessness 85.67 11.09 234 139790 39551 64319157
Thinking abnormal 85.21 11.09 115 139909 11441 64347267
Dystonia 84.43 11.09 149 139875 18716 64339992
Tubulointerstitial nephritis and uveitis syndrome 83.30 11.09 29 139995 255 64358453
Dyspnoea exertional 81.59 11.09 29 139995 73701 64285007
Akathisia 81.03 11.09 112 139912 11398 64347310
Respiratory arrest 80.68 11.09 276 139748 52709 64305999
Chronic obstructive pulmonary disease 80.25 11.09 27 139997 71021 64287687
Musculoskeletal pain 80.20 11.09 38 139986 81256 64277452
Behaviour disorder 80.13 11.09 71 139953 4391 64354317
Oedema peripheral 79.87 11.09 215 139809 210102 64148606
Hypogammaglobulinaemia 79.79 11.09 105 139919 10194 64348514
Electrocardiogram QT prolonged 78.98 11.09 362 139662 79086 64279622
Postictal psychosis 78.60 11.09 24 140000 132 64358576
Rash macular 77.68 11.09 164 139860 23521 64335187
General physical health deterioration 77.61 11.09 209 139815 204216 64154492
Arthritis 77.00 11.09 43 139981 83771 64274937
Memory impairment 76.18 11.09 378 139646 85304 64273404
Maternal exposure during breast feeding 76.17 11.09 50 139974 1966 64356742
Acute myocardial infarction 76.16 11.09 28 139996 69690 64289018
Sinus tachycardia 76.08 11.09 196 139828 31992 64326716
Apathy 75.65 11.09 107 139917 11125 64347583
Dyskinesia 75.38 11.09 222 139802 39166 64319542
Camptocormia 75.16 11.09 31 139993 450 64358258
Partial seizures with secondary generalisation 74.48 11.09 31 139993 461 64358247
Asthenia 74.43 11.09 584 139440 427460 63931248
Dysarthria 74.05 11.09 290 139734 59116 64299592
Sedation 73.98 11.09 228 139796 41234 64317474
Sopor 73.63 11.09 184 139840 29477 64329231
Toxic skin eruption 73.34 11.09 142 139882 19142 64339566
Intentional product use issue 72.80 11.09 60 139964 95304 64263404
Mental disorder 72.00 11.09 170 139854 26275 64332433
Impaired healing 71.84 11.09 21 140003 60452 64298256
Cardiac arrest 71.77 11.09 576 139448 153488 64205220
Epileptic aura 71.35 11.09 19 140005 57 64358651
Ascites 71.01 11.09 23 140001 61978 64296730
Interstitial lung disease 70.35 11.09 65 139959 97667 64261041
Rash papular 70.01 11.09 130 139894 16983 64341725
Cerebellar syndrome 69.30 11.09 69 139955 4947 64353761
Crying 69.27 11.09 142 139882 19948 64338760
Catatonia 69.05 11.09 84 139940 7536 64351172
Rectal haemorrhage 68.93 11.09 24 140000 61793 64296915
Dehydration 68.50 11.09 241 139783 216522 64142186
Eyelid erosion 68.35 11.09 18 140006 51 64358657
Mobility decreased 68.05 11.09 52 139972 85788 64272920
Cheilitis 67.96 11.09 66 139958 4590 64354118
Dizziness 67.40 11.09 1309 138715 428854 63929854
Renal failure 67.28 11.09 188 139836 181500 64177208
Altered state of consciousness 67.23 11.09 208 139816 37694 64321014
Antipsychotic drug level increased 66.34 11.09 68 139956 5047 64353661
Abdominal pain 66.21 11.09 402 139622 311973 64046735
Bronchitis 65.36 11.09 84 139940 108659 64250049
Encephalopathy 65.28 11.09 277 139747 58542 64300166
Renal impairment 65.16 11.09 121 139903 134896 64223812
Retinal pigment epitheliopathy 64.87 11.09 26 139998 349 64358359
Tic 64.40 11.09 50 139974 2569 64356139
Psychomotor retardation 64.23 11.09 67 139957 5076 64353632
Papule 64.15 11.09 74 139950 6276 64352432
Exposure via ingestion 63.28 11.09 65 139959 4837 64353871
Infarction 63.25 11.09 59 139965 3901 64354807
Pleural effusion 63.25 11.09 111 139913 126448 64232260
Plasma cell myeloma 62.61 11.09 12 140012 46063 64312645
Wound 62.33 11.09 45 139979 76432 64282276
Muscle twitching 61.67 11.09 131 139893 18867 64339841
Mucosal disorder 61.62 11.09 52 139972 3010 64355698
Unresponsive to stimuli 61.19 11.09 244 139780 50149 64308559
Trichiasis 61.10 11.09 17 140007 63 64358645
Parkinsonism 61.09 11.09 111 139913 14262 64344446
Pyrexia 60.35 11.09 1613 138411 557031 63801677
Poisoning deliberate 59.84 11.09 106 139918 13352 64345356
Neutropenia 59.77 11.09 292 139732 239332 64119376
Productive cough 59.76 11.09 43 139981 73160 64285548
Overweight 59.60 11.09 53 139971 3293 64355415
Blood pressure systolic increased 59.06 11.09 17 140007 49436 64309272
Oral disorder 58.63 11.09 84 139940 8837 64349871
Mental impairment 58.11 11.09 117 139907 16226 64342482
Paranoia 58.06 11.09 117 139907 16235 64342473
Discomfort 57.96 11.09 54 139970 80824 64277884
Exposure via breast milk 57.43 11.09 30 139994 764 64357944
Fluid retention 57.07 11.09 29 139995 59577 64299131
Gaze palsy 56.94 11.09 46 139978 2504 64356204
Depressive symptom 56.92 11.09 59 139965 4437 64354271
Haemoptysis 56.51 11.09 18 140006 49030 64309678
Logorrhoea 56.38 11.09 56 139968 4003 64354705
Deep vein thrombosis 55.56 11.09 89 139935 105093 64253615
Therapeutic product effect decreased 55.11 11.09 104 139920 115247 64243461
Speech disorder developmental 54.89 11.09 26 139998 533 64358175
Pulmonary embolism 54.50 11.09 151 139873 146205 64212503
Gastrointestinal disorder 54.21 11.09 69 139955 89640 64269068
Haematochezia 54.16 11.09 39 139985 66334 64292374
Live birth 53.41 11.09 91 139933 11113 64347595
Neovascularisation 53.36 11.09 32 139992 1071 64357637
Cataplexy 53.35 11.09 29 139995 802 64357906
Treatment noncompliance 53.16 11.09 211 139813 43271 64315437
Blood pressure fluctuation 53.10 11.09 23 140001 51848 64306860
Pulmonary hypertension 53.07 11.09 14 140010 43125 64315583
Mood swings 52.76 11.09 117 139907 17351 64341357
Epidermal necrosis 52.04 11.09 34 139990 1326 64357382
Nausea 51.35 11.09 1307 138717 784493 63574215
Speech disorder 51.35 11.09 225 139799 48216 64310492
Lung disorder 50.41 11.09 35 139989 60665 64298043
Anticonvulsant drug level below therapeutic 50.30 11.09 30 139994 994 64357714
Lactic acidosis 50.22 11.09 36 139988 61374 64297334
Psychomotor skills impaired 49.66 11.09 51 139973 3794 64354914
Skin degenerative disorder 49.52 11.09 12 140012 21 64358687
Learning disorder 49.38 11.09 24 140000 522 64358186
Therapeutic response unexpected 49.26 11.09 112 139912 16889 64341819
Impulsive behaviour 49.07 11.09 43 139981 2620 64356088
Distributive shock 48.74 11.09 37 139987 1838 64356870
Dysmetria 48.62 11.09 28 139996 868 64357840
Abdominal pain upper 48.58 11.09 205 139819 174825 64183883
Diverticulitis 48.53 11.09 12 140012 38606 64320102
Confusional state 48.32 11.09 816 139208 260328 64098380
Irritable bowel syndrome 48.17 11.09 11 140013 37358 64321350
Ischaemic stroke 48.02 11.09 4 140020 29031 64329677
Enanthema 47.96 11.09 26 139998 715 64357993
Alopecia 47.90 11.09 191 139833 165499 64193209
Hallucination, visual 47.75 11.09 151 139873 27683 64331025
Blepharospasm 47.69 11.09 47 139977 3328 64355380
Major depression 47.60 11.09 71 139953 7745 64350963
Injection site erythema 47.59 11.09 50 139974 70750 64287958
Hallucination 47.24 11.09 295 139729 72493 64286215
Skin exfoliation 47.21 11.09 208 139816 44677 64314031
Melaena 47.01 11.09 29 139995 53519 64305189
Platelet count decreased 46.81 11.09 196 139828 167515 64191193
Drug withdrawal convulsions 46.70 11.09 38 139986 2090 64356618
Lip ulceration 46.61 11.09 37 139987 1964 64356744
Staring 46.60 11.09 40 139984 2370 64356338
Constipation 46.56 11.09 299 139725 229038 64129670
Abulia 46.11 11.09 27 139997 864 64357844
Cellulitis 46.01 11.09 83 139941 93574 64265134
Blood prolactin increased 45.93 11.09 47 139977 3481 64355227
Transaminases increased 45.65 11.09 205 139819 44389 64314319
Drug screen false positive 45.46 11.09 28 139996 984 64357724
C-reactive protein abnormal 45.40 11.09 5 140019 29042 64329666
Illusion 45.33 11.09 33 139991 1537 64357171
Chest discomfort 45.33 11.09 117 139907 115989 64242719
Loss of consciousness 45.23 11.09 507 139517 147858 64210850
Mouth ulceration 45.08 11.09 164 139860 32280 64326428
Influenza 45.02 11.09 103 139921 106428 64252280
Decreased appetite 44.63 11.09 393 139631 280896 64077812
Angina pectoris 44.57 11.09 21 140003 45060 64313648
Upper gastrointestinal haemorrhage 44.15 11.09 11 140013 35209 64323499
Cytomegalovirus infection 44.03 11.09 13 140011 37186 64321522
Inappropriate affect 43.99 11.09 30 139994 1258 64357450
Cerebral infarction 43.96 11.09 17 140007 41027 64317681
Neoplasm progression 43.82 11.09 17 140007 40947 64317761
Postictal state 43.81 11.09 33 139991 1620 64357088
Irregular sleep phase 43.77 11.09 13 140011 64 64358644
Osteonecrosis of jaw 43.48 11.09 16 140008 39809 64318899
Pulmonary oedema 43.04 11.09 65 139959 78609 64280099
Heart rate decreased 42.82 11.09 34 139990 55033 64303675
Folliculitis 42.68 11.09 7 140017 30070 64328638
Increased appetite 42.67 11.09 78 139946 10068 64348640
Hypomagnesaemia 42.56 11.09 14 140010 37362 64321346
Osteoarthritis 42.27 11.09 45 139979 63291 64295417
Salivary hypersecretion 42.21 11.09 86 139938 12027 64346681
Pericarditis 42.19 11.09 44 139980 62472 64296236
Malaise 42.17 11.09 606 139418 395641 63963067
Pharyngeal erythema 41.99 11.09 33 139991 1726 64356982
Accidental overdose 41.96 11.09 164 139860 33393 64325315
Affective disorder 41.85 11.09 61 139963 6519 64352189
Euphoric mood 41.77 11.09 61 139963 6530 64352178
Suicide threat 41.64 11.09 12 140012 52 64358656
Haematuria 41.44 11.09 42 139982 60429 64298279
Oculomucocutaneous syndrome 41.23 11.09 18 140006 303 64358405
Colitis 41.08 11.09 40 139984 58634 64300074
Glossodynia 40.95 11.09 48 139976 64648 64294060
Wheezing 40.86 11.09 70 139954 80509 64278199
Psychogenic seizure 40.66 11.09 33 139991 1808 64356900
Pulmonary arterial hypertension 40.59 11.09 4 140020 25363 64333345
Caesarean section 40.43 11.09 81 139943 11193 64347515
Abdominal distension 40.41 11.09 93 139931 95901 64262807
Obsessive thoughts 40.33 11.09 26 139998 991 64357717
Pain in jaw 40.27 11.09 19 140005 40736 64317972
Mucosal inflammation 40.08 11.09 46 139978 62538 64296170
Tonic convulsion 40.04 11.09 33 139991 1848 64356860
Blister 40.03 11.09 307 139717 80660 64278048
Distractibility 39.97 11.09 22 140002 624 64358084
Injection site pain 39.95 11.09 117 139907 111291 64247417
Sleep disorder due to general medical condition, insomnia type 39.87 11.09 5 140019 26265 64332443
Persecutory delusion 39.58 11.09 47 139977 4111 64354597
Blood creatinine increased 39.57 11.09 156 139868 135626 64223082
Product dispensing error 39.55 11.09 81 139943 11369 64347339
Unintended pregnancy 39.45 11.09 41 139983 3093 64355615
Hypertonia 39.30 11.09 58 139966 6267 64352441
Inappropriate antidiuretic hormone secretion 39.23 11.09 122 139902 22167 64336541
Nasal congestion 39.13 11.09 43 139981 59615 64299093
Pregnancy on oral contraceptive 38.94 11.09 23 140001 748 64357960
Temporal lobe epilepsy 38.68 11.09 18 140006 354 64358354
Therapeutic response changed 38.63 11.09 25 139999 959 64357749
Vision blurred 38.46 11.09 331 139693 89985 64268723
Blood creatine phosphokinase increased 38.42 11.09 238 139786 58320 64300388
Wrong schedule 37.95 11.09 17 140007 305 64358403
Gambling disorder 37.78 11.09 32 139992 1862 64356846
Metastases to liver 37.73 11.09 4 140020 23937 64334771
Hostility 37.42 11.09 34 139990 2173 64356535
Disorientation 37.32 11.09 228 139796 55600 64303108
Educational problem 37.27 11.09 18 140006 386 64358322
Drug titration error 37.20 11.09 24 140000 916 64357792
Thrombosis 37.09 11.09 60 139964 70582 64288126
Erythema of eyelid 36.71 11.09 32 139992 1936 64356772
Simple partial seizures 36.49 11.09 21 140003 650 64358058
Tonic clonic movements 36.42 11.09 32 139992 1957 64356751
Affect lability 36.41 11.09 68 139956 8922 64349786
Coordination abnormal 36.27 11.09 92 139932 14872 64343836
Drug clearance increased 36.17 11.09 15 140009 221 64358487
Pneumocystis jirovecii pneumonia 35.88 11.09 8 140016 27626 64331082
Migraine 35.79 11.09 246 139778 62431 64296277
Intellectual disability 35.63 11.09 24 140000 986 64357722
Change in seizure presentation 35.52 11.09 16 140008 291 64358417
Oral mucosal blistering 35.43 11.09 50 139974 5187 64353521
Lung neoplasm malignant 35.34 11.09 3 140021 21445 64337263
Lymphangioleiomyomatosis 35.34 11.09 13 140011 136 64358572
Dysmorphism 35.10 11.09 19 140005 521 64358187
Bone pain 34.99 11.09 31 139993 47541 64311167
Urinary tract infection 34.79 11.09 328 139696 231268 64127440
Tachycardia 34.79 11.09 486 139538 149093 64209615
Septic shock 34.79 11.09 115 139909 105322 64253386
Ureteric perforation 34.61 11.09 8 140016 10 64358698
Learning disability 34.60 11.09 14 140010 193 64358515
Cerebellar atrophy 34.41 11.09 24 140000 1044 64357664
Negative symptoms in schizophrenia 34.22 11.09 12 140012 108 64358600
Asthma 34.15 11.09 100 139924 95125 64263583
Pregnancy with implant contraceptive 33.95 11.09 27 139997 1437 64357271
Skin erosion 33.94 11.09 42 139982 3834 64354874
Rapid eye movement sleep behaviour disorder 33.91 11.09 16 140008 325 64358383
Placental disorder 33.90 11.09 22 140002 848 64357860
Human herpesvirus 6 infection 33.83 11.09 46 139978 4608 64354100
Epistaxis 33.79 11.09 105 139919 98026 64260682
Systemic lupus erythematosus 33.64 11.09 74 139950 77538 64281170
Drug abuse 33.62 11.09 437 139587 131937 64226771
Femur fracture 33.59 11.09 16 140008 34119 64324589
Benzodiazepine drug level increased 33.59 11.09 14 140010 209 64358499
Photophobia 33.59 11.09 98 139926 17195 64341513
Traumatic coma 33.54 11.09 10 140014 50 64358658
Derealisation 33.45 11.09 27 139997 1468 64357240
Delirium 33.45 11.09 261 139763 68933 64289775
Personality disorder 33.40 11.09 46 139978 4665 64354043
Gait disturbance 33.31 11.09 542 139482 171613 64187095
Intermenstrual bleeding 33.30 11.09 48 139976 5077 64353631
Erythema 33.29 11.09 581 139443 186489 64172219
Cerebral atrophy 33.19 11.09 58 139966 7227 64351481
Libido increased 33.18 11.09 29 139995 1761 64356947
Haemorrhoids 33.14 11.09 6 140018 23995 64334713
Hypokalaemia 33.06 11.09 144 139880 121759 64236949
Excessive eye blinking 33.05 11.09 25 139999 1235 64357473
Angiofibroma 33.02 11.09 12 140012 121 64358587
Peritonitis 32.99 11.09 7 140017 25016 64333692
Seizure cluster 32.92 11.09 16 140008 348 64358360
Product administration error 32.87 11.09 133 139891 27510 64331198
Osteoporosis 32.70 11.09 26 139998 42054 64316654
Aphasia 32.54 11.09 175 139849 40731 64317977
Weight decreased 32.51 11.09 431 139593 285308 64073400
Cataract 32.48 11.09 38 139986 51224 64307484
Autism spectrum disorder 32.33 11.09 22 140002 919 64357789
Psoriatic arthropathy 32.08 11.09 28 139996 43253 64315455
Oxygen saturation decreased 31.95 11.09 122 139902 107054 64251654
Rash vesicular 31.93 11.09 46 139978 4864 64353844
Retinogram abnormal 31.87 11.09 15 140009 303 64358405
Chapped lips 31.85 11.09 30 139994 2008 64356700
SJS-TEN overlap 31.47 11.09 17 140007 464 64358244
Localised infection 31.47 11.09 13 140011 30148 64328560
Hypersensitivity 31.34 11.09 274 139750 196178 64162530
Syncope 31.22 11.09 207 139817 157428 64201280
Pulmonary fibrosis 30.98 11.09 13 140011 29865 64328843
Paradoxical drug reaction 30.89 11.09 51 139973 6069 64352639
Palmar-plantar erythrodysaesthesia syndrome 30.76 11.09 12 140012 28807 64329901
Psychotic symptom 30.63 11.09 30 139994 2108 64356600
Hypotension 30.63 11.09 613 139411 380361 63978347
Granulocytopenia 30.49 11.09 69 139955 10371 64348337
Coma scale abnormal 30.48 11.09 58 139966 7716 64350992
Withdrawal syndrome 30.34 11.09 116 139908 23376 64335332
Gestational diabetes 30.14 11.09 48 139976 5542 64353166
Gastric ulcer 30.02 11.09 14 140010 30220 64328488
Mucosal erosion 29.33 11.09 28 139996 1906 64356802
Device related infection 29.16 11.09 15 140009 30611 64328097
Hypoglycaemia 29.00 11.09 99 139925 89793 64268915
Injection site bruising 28.86 11.09 22 140002 36351 64322357
Dissociation 28.60 11.09 34 139990 2977 64355731
Hypoxia 28.49 11.09 97 139927 88052 64270656
Flat affect 28.38 11.09 27 139997 1830 64356878
Bursitis 28.34 11.09 6 140018 21479 64337229
Right ventricular failure 28.32 11.09 6 140018 21465 64337243
Suspiciousness 28.21 11.09 17 140007 574 64358134
Gout 28.21 11.09 6 140018 21407 64337301
Basal cell carcinoma 28.06 11.09 16 140008 30822 64327886
Multiple congenital abnormalities 28.04 11.09 10 140014 95 64358613
Scab 27.89 11.09 61 139963 8961 64349747
Chronic kidney disease 27.85 11.09 52 139972 57867 64300841
Hyperprolactinaemia 27.78 11.09 39 139985 4026 64354682
Cerebellar ataxia 27.39 11.09 26 139998 1757 64356951
Psychiatric symptom 27.36 11.09 49 139975 6224 64352484
Cytokine release syndrome 27.11 11.09 6 140018 20823 64337885
Automatism 27.09 11.09 11 140013 153 64358555
Injury corneal 27.04 11.09 9 140015 68 64358640
Oral mucosal eruption 26.99 11.09 17 140007 622 64358086
Dysphoria 26.92 11.09 40 139984 4348 64354360
Product use issue 26.75 11.09 206 139818 151509 64207199
Off label use 26.73 11.09 1113 138911 631693 63727015
Cystitis 26.64 11.09 32 139992 42643 64316065
Oesophagitis 26.64 11.09 7 140017 21623 64337085
Full blood count decreased 26.53 11.09 8 140016 22574 64336134
Hyperglycaemia 26.52 11.09 58 139966 60910 64297798
Blood glucose increased 26.50 11.09 116 139908 97957 64260751
Bezoar 26.27 11.09 28 139996 2175 64356533
Pneumonitis 26.23 11.09 43 139981 50322 64308386
Hypotonia 26.21 11.09 68 139956 11144 64347564
Symblepharon 26.16 11.09 11 140013 168 64358540
Pregnancy 26.11 11.09 102 139922 20763 64337945
Hepatotoxicity 25.99 11.09 29 139995 39933 64318775
Microcephaly 25.99 11.09 11 140013 171 64358537
Transfusion 25.95 11.09 4 140020 17990 64340718
Feelings of worthlessness 25.87 11.09 15 140009 471 64358237
Neonatal infection 25.81 11.09 7 140017 23 64358685
Transferrin increased 25.81 11.09 7 140017 23 64358685
Hypervolaemia 25.77 11.09 27 139997 38258 64320450
Intention tremor 25.66 11.09 17 140007 679 64358029
Parasomnia 25.62 11.09 15 140009 480 64358228
Feeling drunk 25.59 11.09 38 139986 4129 64354579
Purpura 25.51 11.09 89 139935 17157 64341551
Haemorrhage 25.18 11.09 88 139936 79263 64279445
Drooling 25.09 11.09 43 139981 5276 64353432
Red blood cell sedimentation rate abnormal 25.00 11.09 3 140021 16303 64342405
Hepatosplenomegaly 24.94 11.09 43 139981 5300 64353408
Angiomyolipoma 24.88 11.09 11 140013 191 64358517
Hepatic cirrhosis 24.86 11.09 13 140011 26285 64332423
Delusional perception 24.82 11.09 13 140011 333 64358375
Postictal paralysis 24.78 11.09 13 140011 334 64358374
Bundle branch block right 24.75 11.09 63 139961 10206 64348502
Delivery 24.59 11.09 15 140009 518 64358190
Knee arthroplasty 24.57 11.09 14 140010 26985 64331723
Drug resistance 24.50 11.09 145 139879 34957 64323751
Cerebral haemorrhage 24.44 11.09 46 139978 51044 64307664
Tachyphrenia 24.44 11.09 25 139999 1851 64356857
Skin ulcer 24.37 11.09 36 139988 43938 64314770
Joint range of motion decreased 24.32 11.09 6 140018 19337 64339371
Hip arthroplasty 24.30 11.09 8 140016 21343 64337365
Blood pressure diastolic decreased 24.28 11.09 9 140015 22292 64336416
Fibromyalgia 24.27 11.09 25 139999 35706 64323002
Wrong patient received product 24.10 11.09 35 139989 3727 64354981
Premature labour 24.10 11.09 52 139972 7568 64351140
Oedema 24.08 11.09 110 139914 91825 64266883
Dermatitis bullous 24.07 11.09 69 139955 11985 64346723
Pulmonary mass 24.03 11.09 11 140013 24005 64334703
Convulsive threshold lowered 23.94 11.09 18 140006 881 64357827
Tongue biting 23.92 11.09 24 140000 1736 64356972
Lennox-Gastaut syndrome 23.89 11.09 11 140013 211 64358497
Developmental delay 23.78 11.09 19 140005 1018 64357690
Therapeutic product effective for unapproved indication 23.75 11.09 9 140015 103 64358605
Galactorrhoea 23.68 11.09 32 139992 3187 64355521
Hypercalcaemia 23.68 11.09 20 140004 31396 64327312
Haematemesis 23.67 11.09 41 139983 46958 64311750
COVID-19 23.65 11.09 68 139956 65072 64293636
Neoplasm malignant 23.64 11.09 12 140012 24676 64334032
Cardiac disorder 23.55 11.09 54 139970 55762 64302946
Drug dose titration not performed 23.54 11.09 16 140008 667 64358041
Hyperexplexia 23.48 11.09 7 140017 35 64358673
Sleep disorder 23.44 11.09 215 139809 59494 64299214
Product quality issue 23.37 11.09 127 139897 29672 64329036
Lip scab 23.33 11.09 5 140019 3 64358705
Plagiocephaly 23.33 11.09 6 140018 15 64358693
Atrial septal defect 23.32 11.09 23 140001 1630 64357078
Eyelid oedema 23.29 11.09 69 139955 12210 64346498
Premature baby 23.27 11.09 32 139992 3240 64355468
Urinary incontinence 23.13 11.09 146 139878 36005 64322703
Altered pitch perception 23.05 11.09 6 140018 16 64358692
Bacteraemia 23.04 11.09 15 140009 26896 64331812
Adrenal insufficiency 22.97 11.09 10 140014 22477 64336231
Metastases to lung 22.94 11.09 3 140021 15261 64343447
Mental status changes 22.89 11.09 218 139806 60944 64297764
Developmental regression 22.85 11.09 7 140017 39 64358669
Osteomyelitis 22.78 11.09 16 140008 27571 64331137
Amnesia 22.73 11.09 181 139843 48088 64310620
Clostridium difficile infection 22.70 11.09 27 139997 36136 64322572
Nightmare 22.62 11.09 98 139926 20895 64337813
Decreased interest 22.61 11.09 32 139992 3328 64355380
Eosinophilic myocarditis 22.56 11.09 17 140007 835 64357873
Histiocytosis 22.56 11.09 7 140017 41 64358667
Brain death 22.54 11.09 39 139985 4822 64353886
Lymphadenitis 22.50 11.09 34 139990 3751 64354957
Heart rate irregular 22.50 11.09 16 140008 27397 64331311
Acute coronary syndrome 22.40 11.09 7 140017 19303 64339405
Sternal fracture 22.39 11.09 26 139998 2221 64356487
Soft tissue injury 22.33 11.09 22 140002 1557 64357151
Pulmonary congestion 22.29 11.09 12 140012 23868 64334840
Posture abnormal 22.28 11.09 32 139992 3374 64355334
Clostridium difficile colitis 22.20 11.09 16 140008 27207 64331501
Mitral valve incompetence 22.18 11.09 14 140010 25524 64333184
Disseminated intravascular coagulation 22.18 11.09 133 139891 32215 64326493
Hospitalisation 22.16 11.09 86 139938 75121 64283587
Apnoea 22.13 11.09 61 139963 10361 64348347
Hyperammonaemia 22.06 11.09 59 139965 9845 64348863
Retinal deposits 22.05 11.09 9 140015 127 64358581
Anaphylactic shock 22.02 11.09 20 140004 30308 64328400
Regressive behaviour 21.98 11.09 8 140016 81 64358627
Skin lesion 21.91 11.09 145 139879 36337 64322371
Persistent depressive disorder 21.84 11.09 18 140006 1008 64357700
Hiatus hernia 21.82 11.09 8 140016 19949 64338759
Tongue eruption 21.81 11.09 8 140016 83 64358625
Pseudolymphoma 21.79 11.09 18 140006 1011 64357697
Essential tremor 21.74 11.09 20 140004 1299 64357409
Lethargy 21.61 11.09 247 139777 72347 64286361
Myalgia 21.57 11.09 230 139794 158387 64200321
Differential white blood cell count abnormal 21.57 11.09 23 140001 1787 64356921
Self-medication 21.54 11.09 35 139989 4110 64354598
Prostate cancer 21.53 11.09 8 140016 19787 64338921
Cardiovascular symptom 21.49 11.09 7 140017 49 64358659
Dermatitis exfoliative 21.40 11.09 60 139964 10292 64348416
Idiopathic generalised epilepsy 21.37 11.09 7 140017 50 64358658
Treatment failure 21.35 11.09 157 139867 116659 64242049
Cholestasis of pregnancy 21.32 11.09 17 140007 908 64357800
Eye discharge 21.27 11.09 39 139985 5045 64353663
Bacterial infection 21.23 11.09 14 140010 24936 64333772
Sleep-related eating disorder 21.22 11.09 15 140009 667 64358041
Chills 21.20 11.09 193 139831 137071 64221637
International normalised ratio increased 21.17 11.09 94 139930 79073 64279635
Brain malformation 21.14 11.09 7 140017 52 64358656
Genital erosion 21.13 11.09 12 140012 362 64358346
Ventricular septal defect 21.13 11.09 13 140011 456 64358252
Attention deficit hyperactivity disorder 21.09 11.09 28 139996 2742 64355966
Sinus congestion 21.02 11.09 4 140020 15435 64343273
Miosis 20.98 11.09 70 139954 13196 64345512
Snoring 20.97 11.09 37 139987 4645 64354063
Nephropathy toxic 20.95 11.09 6 140018 17508 64341200
Hypothermia 20.86 11.09 92 139932 19764 64338944
Myelosuppression 20.78 11.09 13 140011 23817 64334891
Macule 20.78 11.09 26 139998 2400 64356308
Terminal insomnia 20.70 11.09 17 140007 947 64357761
Lip oedema 20.70 11.09 39 139985 5150 64353558
Lymphocytic infiltration 20.67 11.09 20 140004 1384 64357324
Stomatitis 20.67 11.09 146 139878 109459 64249249
Resting tremor 20.55 11.09 20 140004 1394 64357314
Cleft lip 20.54 11.09 4 140020 0 64358708
Schizophrenia 20.46 11.09 62 139962 11106 64347602
Vulvar erosion 20.43 11.09 9 140015 155 64358553
Viral rash 20.34 11.09 11 140013 301 64358407
Bronchopulmonary aspergillosis 20.28 11.09 8 140016 19077 64339631
Blood potassium increased 20.25 11.09 16 140008 25964 64332744
Respiratory failure 20.23 11.09 238 139786 160945 64197763
Movement disorder 20.21 11.09 98 139926 21902 64336806
Conjunctival abrasion 20.20 11.09 5 140019 10 64358698
Maternal drugs affecting foetus 20.04 11.09 21 140003 1599 64357109
Lymphocyte morphology abnormal 20.04 11.09 16 140008 856 64357852
Hepatocellular injury 19.89 11.09 167 139857 45068 64313640
Bone marrow failure 19.74 11.09 47 139977 47905 64310803
Placental infarction 19.72 11.09 8 140016 111 64358597
Somnambulism 19.72 11.09 38 139986 5103 64353605
Hypersomnia 19.70 11.09 90 139934 19627 64339081
Visual field defect 19.66 11.09 50 139974 8096 64350612
Bile acid malabsorption 19.58 11.09 9 140015 172 64358536
Congenital anomaly 19.42 11.09 10 140014 247 64358461
Self esteem decreased 19.34 11.09 16 140008 901 64357807
Haematocrit decreased 19.15 11.09 58 139966 54597 64304111
Judgement impaired 19.12 11.09 17 140007 1056 64357652
Nephrogenic diabetes insipidus 19.08 11.09 22 140002 1865 64356843
Sleep paralysis 19.06 11.09 13 140011 545 64358163
Fungal infection 19.02 11.09 28 139996 34223 64324485
Homicidal ideation 19.00 11.09 29 139995 3228 64355480
Gastritis 18.99 11.09 40 139984 42578 64316130
Ocular hyperaemia 18.95 11.09 98 139926 22466 64336242
Post-traumatic neck syndrome 18.94 11.09 22 140002 1880 64356828
Exomphalos 18.88 11.09 7 140017 75 64358633
Palpitations 18.82 11.09 141 139883 104347 64254361
Rash pruritic 18.78 11.09 199 139825 57205 64301503
Intestinal perforation 18.78 11.09 5 140019 15308 64343400
Echolalia 18.67 11.09 11 140013 356 64358352
Incorrect dose administered 18.65 11.09 208 139816 60557 64298151
Contusion 18.58 11.09 158 139866 113807 64244901
Vomiting projectile 18.56 11.09 20 140004 1573 64357135
Lipids 18.53 11.09 5 140019 16 64358692
Conjunctival disorder 18.48 11.09 10 140014 274 64358434
Strabismus 18.46 11.09 23 140001 2114 64356594
Immunodeficiency 18.43 11.09 6 140018 16118 64342590
Flight of ideas 18.41 11.09 14 140010 697 64358011
Epidermolysis 18.37 11.09 12 140012 468 64358240
Selective IgA immunodeficiency 18.31 11.09 4 140020 3 64358705
Haematotoxicity 18.30 11.09 3 140021 12893 64345815
Tricuspid valve incompetence 18.28 11.09 7 140017 16996 64341712
Wrong product administered 18.23 11.09 47 139977 7673 64351035
Colitis ulcerative 18.18 11.09 14 140010 23014 64335694
Lower gastrointestinal haemorrhage 18.17 11.09 4 140020 13935 64344773
Tonsillar hypertrophy 18.16 11.09 18 140006 1283 64357425
Torticollis 18.12 11.09 23 140001 2154 64356554
Unevaluable event 18.11 11.09 53 139971 50436 64308272
Economic problem 18.04 11.09 23 140001 2164 64356544
White blood cell count decreased 17.96 11.09 238 139786 157599 64201109
Drop attacks 17.93 11.09 16 140008 999 64357709
Shock haemorrhagic 17.91 11.09 7 140017 16784 64341924
Angular cheilitis 17.83 11.09 12 140012 492 64358216
Conjunctival scar 17.81 11.09 7 140017 89 64358619
Dyslexia 17.75 11.09 9 140015 215 64358493
Stupor 17.75 11.09 40 139984 5995 64352713
Autoscopy 17.73 11.09 6 140018 48 64358660
Burnout syndrome 17.72 11.09 10 140014 298 64358410
Hepatic encephalopathy 17.68 11.09 12 140012 21054 64337654
Encephalocele 17.67 11.09 5 140019 20 64358688
Blood urea increased 17.60 11.09 44 139980 44109 64314599
Panic attack 17.60 11.09 91 139933 20862 64337846
Leukocytosis 17.49 11.09 141 139883 37599 64321109
Ejection fraction decreased 17.42 11.09 22 140002 28685 64330023
Muscle spasms 17.40 11.09 209 139815 140814 64217894
Compulsive shopping 17.31 11.09 14 140010 763 64357945
Gastric haemorrhage 17.31 11.09 4 140020 13477 64345231
Hip fracture 17.26 11.09 20 140004 27079 64331629
Skin disorder 17.22 11.09 111 139913 27569 64331139
Coprolalia 17.21 11.09 6 140018 53 64358655
Cardiac failure acute 17.12 11.09 7 140017 16337 64342371
Neurosurgery 17.11 11.09 5 140019 23 64358685
Insomnia 17.09 11.09 556 139468 197280 64161428
Hyperhomocysteinaemia 17.04 11.09 11 140013 420 64358288
Spina bifida 17.01 11.09 6 140018 55 64358653
Spinal osteoarthritis 16.99 11.09 5 140019 14336 64344372
Throat irritation 16.96 11.09 28 139996 32683 64326025
Blood cholesterol increased 16.93 11.09 54 139970 50012 64308696
Pyramidal tract syndrome 16.93 11.09 12 140012 536 64358172
Coma scale 16.92 11.09 6 140018 56 64358652
Drug screen positive 16.88 11.09 38 139986 5691 64353017
Transient ischaemic attack 16.87 11.09 45 139979 44137 64314571
Anorgasmia 16.84 11.09 15 140009 934 64357774
Pregnancy with contraceptive device 16.77 11.09 27 139997 3147 64355561
Lymphocyte stimulation test positive 16.75 11.09 16 140008 1090 64357618
Pancytopenia 16.70 11.09 215 139809 143094 64215614
Bronchiectasis 16.63 11.09 5 140019 14135 64344573
Cardiogenic shock 16.59 11.09 28 139996 32399 64326309
Type IV hypersensitivity reaction 16.58 11.09 28 139996 3394 64355314
Hereditary ataxia 16.45 11.09 5 140019 27 64358681
Injection site pruritus 16.44 11.09 36 139988 37790 64320918
Tendonitis 16.44 11.09 12 140012 20270 64338438
Presyncope 16.43 11.09 32 139992 35057 64323651
Gait deviation 16.38 11.09 6 140018 62 64358646
Oscillopsia 16.38 11.09 8 140016 176 64358532
Alopecia universalis 16.38 11.09 8 140016 176 64358532
Squamous cell carcinoma of skin 16.33 11.09 3 140021 11873 64346835
Electrocardiogram ST segment depression 16.30 11.09 32 139992 4357 64354351
Head titubation 16.29 11.09 14 140010 831 64357877
Normal newborn 16.27 11.09 37 139987 5580 64353128
Spinal stenosis 16.25 11.09 5 140019 13926 64344782
Wound infection 16.18 11.09 6 140018 14858 64343850
Herpangina 16.15 11.09 5 140019 29 64358679
Hyperphagia 16.14 11.09 22 140002 2209 64356499
Squamous cell carcinoma 16.13 11.09 5 140019 13864 64344844
Retinal pigmentation 16.12 11.09 6 140018 65 64358643
Blood calcium decreased 16.12 11.09 19 140005 25535 64333173
Emotional disorder 16.07 11.09 62 139962 12545 64346163
Premature rupture of membranes 16.02 11.09 29 139995 3715 64354993
Therapy non-responder 16.00 11.09 81 139943 65818 64292890
Opsoclonus myoclonus 15.98 11.09 8 140016 186 64358522
Red blood cell sedimentation rate increased 15.95 11.09 27 139997 31208 64327500
Drug ineffective for unapproved indication 15.92 11.09 119 139905 31014 64327694
Injection site swelling 15.88 11.09 42 139982 41311 64317397
Myelodysplastic syndrome 15.85 11.09 22 140002 27557 64331151
Congenital renal disorder 15.84 11.09 4 140020 9 64358699
COVID-19 pneumonia 15.84 11.09 8 140016 16496 64342212
Gamma-glutamyltransferase increased 15.79 11.09 168 139856 48342 64310366
Myocarditis 15.71 11.09 76 139948 16967 64341741
Central nervous system lesion 15.71 11.09 59 139965 11790 64346918
Dysphonia 15.70 11.09 50 139974 46332 64312376
Blood pressure decreased 15.68 11.09 116 139908 86083 64272625
Large intestine perforation 15.67 11.09 4 140020 12600 64346108
Intentional product misuse 15.64 11.09 232 139792 72063 64286645
Vulval disorder 15.58 11.09 11 140013 488 64358220
Drug level changed 15.58 11.09 11 140013 488 64358220
Renal tubular necrosis 15.56 11.09 15 140009 22095 64336613
Diabetes mellitus inadequate control 15.55 11.09 14 140010 21307 64337401
Restless legs syndrome 15.55 11.09 76 139948 17040 64341668
Illogical thinking 15.43 11.09 6 140018 74 64358634
Congenital cardiovascular anomaly 15.40 11.09 3 140021 0 64358708
Neonatal aspiration 15.40 11.09 3 140021 0 64358708
Laryngeal tremor 15.40 11.09 3 140021 0 64358708
Peripheral sensory neuropathy 15.38 11.09 3 140021 11375 64347333
Injection site haemorrhage 15.37 11.09 18 140006 24260 64334448
Nodule 15.37 11.09 10 140014 17937 64340771
Pigmentation disorder 15.20 11.09 32 139992 4580 64354128
Gastric disorder 15.13 11.09 25 139999 29172 64329536
Morose 15.11 11.09 5 140019 37 64358671
Musculoskeletal stiffness 15.05 11.09 183 139841 123023 64235685
Epidermolysis bullosa 15.03 11.09 8 140016 212 64358496
Maternal exposure during pregnancy 15.01 11.09 292 139732 95592 64263116
Vestibular migraine 14.98 11.09 7 140017 139 64358569
Maternal exposure before pregnancy 14.93 11.09 27 139997 3456 64355252
Diverticulum 14.93 11.09 5 140019 13193 64345515
Acquired immunodeficiency syndrome 14.89 11.09 8 140016 216 64358492
Tooth malformation 14.87 11.09 6 140018 82 64358626
Bone disorder 14.81 11.09 9 140015 16750 64341958
Limbic encephalitis 14.76 11.09 12 140012 659 64358049
Dysmetropsia 14.68 11.09 6 140018 85 64358623
Flatulence 14.65 11.09 35 139989 35631 64323077
Musculoskeletal chest pain 14.62 11.09 15 140009 21464 64337244
Frequent bowel movements 14.61 11.09 11 140013 18294 64340414
Respiratory depression 14.58 11.09 94 139930 23349 64335359
Thrombocytopenia 14.57 11.09 372 139652 223429 64135279
Borderline personality disorder 14.57 11.09 13 140011 811 64357897
Middle insomnia 14.56 11.09 61 139963 12816 64345892
Blood magnesium decreased 14.50 11.09 6 140018 13899 64344809
Odynophagia 14.48 11.09 50 139974 9591 64349117
Blood loss anaemia 14.47 11.09 6 140018 13886 64344822
Coronary artery occlusion 14.47 11.09 6 140018 13885 64344823
Tongue movement disturbance 14.47 11.09 9 140015 322 64358386
Antipsychotic drug level above therapeutic 14.46 11.09 19 140005 1842 64356866
Hallucinations, mixed 14.45 11.09 37 139987 6015 64352693
Dysphemia 14.43 11.09 25 139999 3094 64355614
Spinal compression fracture 14.42 11.09 7 140017 14768 64343940
Gestational hypertension 14.38 11.09 18 140006 1663 64357045
Pneumothorax 14.35 11.09 19 140005 24279 64334429
Large intestine polyp 14.35 11.09 3 140021 10834 64347874
Aspergillus infection 14.20 11.09 9 140015 16370 64342338
Hallucination, olfactory 14.14 11.09 10 140014 445 64358263
Cholelithiasis 14.08 11.09 51 139973 45455 64313253
Renal injury 14.04 11.09 8 140016 15421 64343287
Brain oedema 14.02 11.09 89 139935 21986 64336722
Acute myopia 14.02 11.09 6 140018 96 64358612
Drug withdrawal syndrome neonatal 14.01 11.09 8 140016 244 64358464
Joint stiffness 14 11.09 28 139996 30376 64328332
Mucosal ulceration 13.99 11.09 18 140006 1709 64356999
Musculoskeletal disorder 13.99 11.09 11 140013 17895 64340813
Sciatica 13.97 11.09 14 140010 20250 64338458
Hyperkinesia 13.92 11.09 22 140002 2524 64356184
Limited symptom panic attack 13.88 11.09 5 140019 49 64358659
Delusion of grandeur 13.77 11.09 11 140013 589 64358119
Tooth disorder 13.77 11.09 17 140007 22385 64336323
Lymphocyte count decreased 13.69 11.09 44 139980 40655 64318053
Hallucination, tactile 13.60 11.09 10 140014 473 64358235
Concussion 13.55 11.09 43 139981 7895 64350813
Conjunctival oedema 13.54 11.09 14 140010 1050 64357658
Hyperventilation 13.51 11.09 39 139985 6801 64351907
Heavy menstrual bleeding 13.49 11.09 57 139967 12020 64346688
Immunodeficiency common variable 13.47 11.09 8 140016 263 64358445
Screaming 13.43 11.09 26 139998 3503 64355205
Exposure via transplant 13.42 11.09 4 140020 20 64358688
Orthostatic hypotension 13.41 11.09 54 139970 46684 64312024
Dyscalculia 13.37 11.09 5 140019 55 64358653
Pharyngeal exudate 13.33 11.09 3 140021 3 64358705
Foetal exposure timing unspecified 13.33 11.09 3 140021 3 64358705
Manic symptom 13.33 11.09 3 140021 3 64358705
Eclampsia 13.30 11.09 7 140017 181 64358527
Attention-seeking behaviour 13.28 11.09 6 140018 110 64358598
Lip disorder 13.25 11.09 15 140009 1246 64357462
Dyspepsia 13.25 11.09 111 139913 80201 64278507
Lipids abnormal 13.19 11.09 10 140014 496 64358212
Injection site rash 13.17 11.09 9 140015 15733 64342975
Heart rate increased 13.04 11.09 144 139880 98531 64260177
Neurotoxicity 13.03 11.09 103 139921 27301 64331407
Respiratory acidosis 13.00 11.09 49 139975 9806 64348902
Protrusion tongue 12.98 11.09 9 140015 388 64358320
Metastases to central nervous system 12.97 11.09 7 140017 13905 64344803
Bruxism 12.95 11.09 26 139998 3598 64355110
False positive investigation result 12.92 11.09 12 140012 789 64357919
Hot flush 12.91 11.09 54 139970 46181 64312527
Oral mucosal erythema 12.90 11.09 17 140007 1652 64357056
Enterococcal infection 12.89 11.09 7 140017 13859 64344849
Hypophosphataemia 12.88 11.09 8 140016 14712 64343996
Osteochondrosis 12.84 11.09 16 140008 1471 64357237
Polyhydramnios 12.84 11.09 16 140008 1471 64357237
Neuropsychiatric symptoms 12.81 11.09 13 140011 953 64357755
Verbigeration 12.81 11.09 4 140020 24 64358684
Human herpesvirus 6 infection reactivation 12.79 11.09 8 140016 289 64358419
Skin cancer 12.75 11.09 5 140019 11969 64346739
Lip haemorrhage 12.75 11.09 14 140010 1125 64357583
Febrile convulsion 12.74 11.09 12 140012 803 64357905
Therapeutic product ineffective for unapproved indication 12.71 11.09 6 140018 122 64358586
Conjunctival ulcer 12.69 11.09 5 140019 64 64358644
Tooth infection 12.69 11.09 8 140016 14593 64344115
Blood pressure systolic abnormal 12.67 11.09 3 140021 9939 64348769
Conversion disorder 12.51 11.09 17 140007 1702 64357006
Feeling of despair 12.43 11.09 21 140003 2547 64356161
Illiteracy 12.41 11.09 4 140020 27 64358681
Lymph node pain 12.41 11.09 15 140009 1337 64357371
Conjunctival irritation 12.37 11.09 6 140018 130 64358578
Physical assault 12.35 11.09 16 140008 1530 64357178
Acute respiratory failure 12.34 11.09 61 139963 49873 64308835
Gastroenteritis 12.32 11.09 29 139995 29682 64329026
Diabetes mellitus 12.31 11.09 89 139935 66385 64292323
Post procedural complication 12.31 11.09 17 140007 21336 64337372
Upper respiratory tract infection 12.27 11.09 100 139924 72685 64286023
Joint effusion 12.24 11.09 7 140017 13466 64345242
Anaphylactic reaction 12.20 11.09 93 139931 68571 64290137
Hypospadias 12.20 11.09 6 140018 134 64358574
Respiratory tract infection 12.19 11.09 41 139983 37366 64321342
Motor developmental delay 12.18 11.09 7 140017 216 64358492
Medication overuse headache 12.16 11.09 11 140013 699 64358009
Hypertensive crisis 12.13 11.09 13 140011 18235 64340473
Congenital renal cyst 12.12 11.09 3 140021 6 64358702
Wound healing normal 12.12 11.09 3 140021 6 64358702
Hyperpyrexia 12.08 11.09 31 139993 5046 64353662
Carpal tunnel syndrome 12.02 11.09 10 140014 15818 64342890
Gastritis erosive 12.02 11.09 3 140021 9592 64349116
Chorea 11.94 11.09 18 140006 1982 64356726
Psoriasis 11.87 11.09 99 139925 71604 64287104
Inflammation 11.81 11.09 88 139936 65212 64293496
Disinhibition 11.74 11.09 19 140005 2224 64356484
Rhinorrhoea 11.74 11.09 79 139945 59890 64298818
Neutrophil count decreased 11.71 11.09 109 139915 77087 64281621
Inappropriate schedule of product administration 11.68 11.09 136 139888 92150 64266558
Failure to thrive 11.66 11.09 4 140020 10400 64348308
Breast cancer 11.66 11.09 29 139995 29119 64329589
Bradykinesia 11.63 11.09 36 139988 6524 64352184
Pancreatic carcinoma 11.61 11.09 4 140020 10369 64348339
Congestive cardiomyopathy 11.56 11.09 4 140020 10340 64348368
Disorganised speech 11.53 11.09 16 140008 1634 64357074
Oral herpes 11.45 11.09 19 140005 22133 64336575
Pemphigoid 11.44 11.09 7 140017 12979 64345729
Rotator cuff syndrome 11.42 11.09 6 140018 12101 64346607
Symptom recurrence 11.42 11.09 12 140012 917 64357791
Ideas of reference 11.41 11.09 6 140018 155 64358553
Acquired epidermolysis bullosa 11.41 11.09 5 140019 85 64358623
Vitamin D deficiency 11.41 11.09 53 139971 11639 64347069
Blood test abnormal 11.37 11.09 7 140017 12936 64345772
Renal disorder 11.37 11.09 39 139985 35326 64323382
Left ventricular dysfunction 11.36 11.09 12 140012 16942 64341766
Tonsillar haemorrhage 11.31 11.09 7 140017 248 64358460
Sinus disorder 11.29 11.09 12 140012 16896 64341812
Head injury 11.28 11.09 115 139909 32727 64325981
Lip erythema 11.27 11.09 6 140018 159 64358549
Antipsychotic drug level decreased 11.26 11.09 12 140012 932 64357776
Bankruptcy 11.22 11.09 4 140020 38 64358670
Acute psychosis 11.18 11.09 25 139999 3727 64354981
Subacute cutaneous lupus erythematosus 11.17 11.09 22 140002 3003 64355705
Pregnancy on contraceptive 11.15 11.09 11 140013 780 64357928
Altered visual depth perception 11.11 11.09 8 140016 366 64358342
Iron deficiency anaemia 11.11 11.09 19 140005 21870 64336838
Creatinine renal clearance decreased 11.09 11.09 9 140015 14412 64344296

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 36.58 18.89 29 2191 3801 78657
Somnolence 22.93 18.89 37 2183 326 82132
Dehydration 22.05 18.89 40 2180 391 82067
Infantile apnoea 20.32 18.89 42 2178 456 82002
Gastrooesophageal reflux disease 19.18 18.89 11 2209 18 82440

Pharmacologic Action:

SourceCodeDescription
ATC N03AX09 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D011619 Psychotropic Drugs
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:60798 EAA receptor antagonists
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Lennox-Gastaut syndrome indication 230418006
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Pancytopenia contraindication 127034005 DOID:12450
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.3 Basic
pKa2 0.0 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
200MG LAMICTAL ODT GLAXOSMITHKLINE LLC N022251 May 8, 2009 RX TABLET, ORALLY DISINTEGRATING ORAL 8840925 July 2, 2028 LAMICTAL IS AN ANTIEPILEPTIC DRUG (AED) INDICATED FOR: EPILEPSY-ADJUNCTIVE THERAPY IN PATIENTS GREATER THAN OR EQUAL TO 2 YEARS OF AGE: (1.1) PARTIAL SEIZURES PRIMARY GENERALIZED TONIC-CLONIC SEIZURES
200MG LAMICTAL ODT GLAXOSMITHKLINE LLC N022251 May 8, 2009 RX TABLET, ORALLY DISINTEGRATING ORAL 9339504 July 2, 2028 LAMICTAL IS AN ANTIEPILEPTIC DRUG (AED) INDICATED FOR: EPILEPSY-ADJUNCTIVE THERAPY IN PATIENTS GREATER THAN OR EQUAL TO 2 YEARS OF AGE: (1.1) PARTIAL SEIZURES PRIMARY GENERALIZED TONIC-CLONIC SEIZURES
25MG LAMICTAL ODT GLAXOSMITHKLINE LLC N022251 May 8, 2009 RX TABLET, ORALLY DISINTEGRATING ORAL 8840925 July 2, 2028 LAMICTAL IS AN ANTIEPILEPTIC DRUG (AED) INDICATED FOR: EPILEPSY-ADJUNCTIVE THERAPY IN PATIENTS GREATER THAN OR EQUAL TO 2 YEARS OF AGE: (1.1) PARTIAL SEIZURES PRIMARY GENERALIZED TONIC-CLONIC SEIZURES
25MG LAMICTAL ODT GLAXOSMITHKLINE LLC N022251 May 8, 2009 RX TABLET, ORALLY DISINTEGRATING ORAL 9339504 July 2, 2028 LAMICTAL IS AN ANTIEPILEPTIC DRUG (AED) INDICATED FOR: EPILEPSY-ADJUNCTIVE THERAPY IN PATIENTS GREATER THAN OR EQUAL TO 2 YEARS OF AGE: (1.1) PARTIAL SEIZURES PRIMARY GENERALIZED TONIC-CLONIC SEIZURES

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 4.21 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER IC50 5 CHEMBL CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.77 CHEMBL CHEMBL
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER IC50 4.02 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 3.84 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel IC50 4.74 WOMBAT-PK
Sodium channel protein type X alpha subunit Ion channel IC50 4.60 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel IC50 4.46 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.51 CHEMBL

External reference:

IDSource
D00354 KEGG_DRUG
4020896 VANDF
C0064636 UMLSCUI
CHEBI:6367 CHEBI
CHEMBL741 ChEMBL_ID
DB00555 DRUGBANK_ID
D000077213 MESH_DESCRIPTOR_UI
3878 PUBCHEM_CID
2622 IUPHAR_LIGAND_ID
5638 INN_ID
U3H27498KS UNII
196502 RXNORM
1506 MMSL
4957 MMSL
69610 MMSL
d03809 MMSL
003988 NDDF
387562000 SNOMEDCT_US
96195007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1526 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1527 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1528 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1529 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9939 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9940 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9941 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9942 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections