lamotrigine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sodium channel blockers, signal transduction modulators 1540 84057-84-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lamictal
  • lamotrigine
  • lamitrin
  • lamotrigin
  • BW 430C
A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
  • Molecular weight: 256.09
  • Formula: C9H7Cl2N5
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 90.71
  • ALOGS: -2.72
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.48 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 27.89 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97.60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.37 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Dec. 27, 1994 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2593.59 10.11 2169 129858 130465 63226530
Drug reaction with eosinophilia and systemic symptoms 2034.65 10.11 1113 130914 32723 63324272
Completed suicide 1516.70 10.11 1685 130342 143988 63213007
Stevens-Johnson syndrome 1409.68 10.11 788 131239 24162 63332833
Exposure during pregnancy 1151.60 10.11 1514 130513 154033 63202962
Intentional overdose 1146.56 10.11 1063 130964 73089 63283906
Toxicity to various agents 1081.29 10.11 1882 130145 245368 63111627
Product substitution issue 813.97 10.11 472 131555 15524 63341471
Generalised tonic-clonic seizure 764.61 10.11 567 131460 28449 63328546
Epilepsy 711.17 10.11 528 131499 26537 63330458
Abortion spontaneous 659.28 10.11 640 131387 46555 63310440
Suicide attempt 645.19 10.11 712 131315 60206 63296789
Toxic epidermal necrolysis 629.51 10.11 478 131549 24856 63332139
Drug interaction 627.05 10.11 1435 130592 227696 63129299
Foetal exposure during pregnancy 514.47 10.11 469 131558 31493 63325502
Intentional self-injury 512.45 10.11 426 131601 25261 63331734
Suicidal ideation 475.50 10.11 617 131410 61804 63295191
Overdose 469.36 10.11 851 131176 114227 63242768
Somnolence 424.54 10.11 1060 130967 177625 63179370
Joint swelling 385.05 10.11 103 131924 327563 63029432
Status epilepticus 370.84 10.11 284 131743 14949 63342046
Nystagmus 363.49 10.11 201 131826 6019 63350976
Arthralgia 360.46 10.11 393 131634 569317 62787678
Rheumatoid arthritis 356.17 10.11 52 131975 253767 63103228
Contraindicated product administered 344.60 10.11 29 131998 217619 63139376
Pemphigus 343.67 10.11 8 132019 183718 63173277
Arthropathy 341.53 10.11 43 131984 234749 63122246
Infusion related reaction 338.31 10.11 53 131974 245468 63111527
Ataxia 332.49 10.11 266 131761 14929 63342066
Synovitis 328.70 10.11 14 132013 186904 63170091
Pain 326.40 10.11 657 131370 739971 62617024
Aggression 324.88 10.11 317 131710 23181 63333814
Tremor 322.86 10.11 793 131234 131446 63225549
Drug level increased 322.38 10.11 311 131716 22425 63334570
Rash maculo-papular 315.59 10.11 360 131667 31536 63325459
Mania 308.59 10.11 234 131793 12133 63344862
Petit mal epilepsy 305.63 10.11 152 131875 3642 63353353
Lymphadenopathy 289.42 10.11 378 131649 38080 63318915
Agitation 286.66 10.11 475 131552 59282 63297713
Diarrhoea 286.55 10.11 669 131358 714697 62642298
Hand deformity 283.52 10.11 11 132016 159446 63197549
Coma 275.02 10.11 486 131541 63878 63293117
Dyspnoea 273.22 10.11 608 131419 660705 62696290
Abdominal discomfort 267.14 10.11 169 131858 320716 63036279
Peripheral swelling 264.52 10.11 111 131916 265831 63091164
Swelling 258.17 10.11 125 131902 275253 63081742
Drug eruption 255.77 10.11 307 131720 28387 63328608
Focal dyscognitive seizures 253.13 10.11 123 131904 2798 63354197
Pneumonia 237.07 10.11 365 131662 456402 62900593
Irritability 234.56 10.11 309 131718 31385 63325610
Depression 232.22 10.11 915 131112 195577 63161418
Serotonin syndrome 222.17 10.11 286 131741 28396 63328599
Oral mucosa erosion 222.14 10.11 86 131941 1097 63355898
Glossodynia 222.03 10.11 50 131977 178826 63178169
Systemic lupus erythematosus 214.53 10.11 83 131944 208835 63148160
Diplopia 213.33 10.11 255 131772 23473 63333522
Multiple-drug resistance 209.84 10.11 132 131895 5038 63351957
Anti-cyclic citrullinated peptide antibody positive 206.61 10.11 8 132019 116204 63240791
Nasopharyngitis 205.95 10.11 138 131889 254119 63102876
Sudden unexplained death in epilepsy 201.27 10.11 58 131969 265 63356730
Alopecia 194.60 10.11 250 131777 337286 63019709
Disturbance in attention 190.44 10.11 309 131718 37880 63319115
Pain in extremity 186.50 10.11 250 131777 331236 63025759
Partial seizures 185.62 10.11 128 131899 5714 63351281
Discomfort 182.89 10.11 60 131967 167314 63189681
Wound 181.10 10.11 57 131970 163206 63193789
Selective eating disorder 178.79 10.11 87 131940 1985 63355010
Anxiety 177.79 10.11 908 131119 216633 63140362
Atrial septal defect 176.90 10.11 133 131894 6805 63350190
Abnormal behaviour 175.99 10.11 220 131807 21206 63335789
Lip erosion 171.70 10.11 68 131959 925 63356070
Bipolar disorder 171.26 10.11 138 131889 7822 63349173
Infection 166.74 10.11 139 131888 229034 63127961
Helicobacter infection 166.26 10.11 6 132021 92779 63264216
Myoclonic epilepsy 166.22 10.11 71 131956 1183 63355812
Abortion induced 166.12 10.11 151 131876 10091 63346904
Erythema multiforme 165.08 10.11 150 131877 10019 63346976
Drug intolerance 164.42 10.11 242 131785 308419 63048576
Maternal exposure during breast feeding 163.94 10.11 105 131922 4136 63352859
Myoclonus 163.57 10.11 183 131844 15685 63341310
Anticonvulsant drug level decreased 163.03 10.11 70 131957 1182 63355813
Rheumatoid factor positive 160.43 10.11 3 132024 84403 63272592
Duodenal ulcer perforation 155.02 10.11 6 132021 87203 63269792
Psychotic disorder 154.79 10.11 227 131800 25485 63331510
Fatigue 152.91 10.11 1152 130875 886876 62470119
Lower respiratory tract infection 152.53 10.11 43 131984 132264 63224731
Poisoning 151.61 10.11 164 131863 13536 63343459
Conjunctival hyperaemia 150.42 10.11 81 131946 2298 63354697
Rash 148.48 10.11 1799 130228 559072 62797923
Haemophagocytic lymphohistiocytosis 146.18 10.11 143 131884 10484 63346511
Therapeutic product effect decreased 144.46 10.11 114 131913 193073 63163922
Ventricular septal defect 144.01 10.11 98 131929 4280 63352715
Anaemia 143.97 10.11 243 131784 293187 63063808
Cardio-respiratory arrest 143.43 10.11 357 131670 59602 63297393
Sinusitis 141.02 10.11 158 131869 226495 63130500
Clonus 138.93 10.11 98 131929 4538 63352457
Hyperreflexia 138.66 10.11 108 131919 5826 63351169
Tardive dyskinesia 137.21 10.11 125 131902 8377 63348618
Toxic skin eruption 136.94 10.11 151 131876 12734 63344261
Extrapyramidal disorder 136.58 10.11 153 131874 13131 63343864
Aura 136.47 10.11 59 131968 1014 63355981
Electrocardiogram QRS complex prolonged 136.43 10.11 107 131920 5831 63351164
Obsessive-compulsive disorder 136.21 10.11 92 131935 3968 63353027
Pericarditis 133.81 10.11 53 131974 131526 63225469
Anticonvulsant drug level increased 131.81 10.11 64 131963 1453 63355542
Rash morbilliform 127.73 10.11 82 131945 3243 63353752
Hyperthermia 123.69 10.11 122 131905 9034 63347961
Mobility decreased 122.88 10.11 49 131978 121110 63235885
Neuroleptic malignant syndrome 122.49 10.11 138 131889 11918 63345077
Disease progression 122.30 10.11 51 131976 122707 63234288
Depressed level of consciousness 121.45 10.11 343 131684 61735 63295260
Pleurothotonus 120.50 10.11 58 131969 1291 63355704
Impaired healing 118.79 10.11 33 131994 102509 63254486
Blepharospasm 118.61 10.11 99 131928 5897 63351098
Back pain 118.58 10.11 231 131796 263914 63093081
Cardiac arrest 114.06 10.11 437 131590 92108 63264887
Muscle rigidity 114.05 10.11 130 131897 11370 63345625
Intentional product use issue 113.83 10.11 62 131965 127830 63229165
Suicidal behaviour 113.72 10.11 70 131957 2569 63354426
Infarction 113.67 10.11 70 131957 2571 63354424
Drug level decreased 113.50 10.11 109 131918 7810 63349185
Eosinophilia 111.90 10.11 183 131844 22573 63334422
Face oedema 111.05 10.11 171 131856 20041 63336954
Hypersensitivity 110.10 10.11 282 131745 292403 63064592
Maternal drugs affecting foetus 108.81 10.11 89 131938 5153 63351842
Atrial fibrillation 107.56 10.11 54 131973 116582 63240413
Akathisia 107.41 10.11 113 131914 9033 63347962
Folliculitis 106.84 10.11 11 132016 70306 63286689
Meningitis aseptic 106.71 10.11 85 131942 4738 63352257
Product use issue 105.92 10.11 185 131842 220335 63136660
Muscle injury 105.29 10.11 8 132019 65337 63291658
Cross sensitivity reaction 105.19 10.11 62 131965 2100 63354895
Irritable bowel syndrome 104.30 10.11 22 132005 82390 63274605
Dyskinesia 103.76 10.11 215 131812 31787 63325208
Pregnancy 101.78 10.11 232 131795 36604 63320391
Cough 101.15 10.11 294 131733 292449 63064546
Anger 100.85 10.11 127 131900 12329 63344666
Caesarean section 100.54 10.11 149 131878 16883 63340112
Cognitive disorder 100.13 10.11 299 131728 55516 63301479
Delusion 99.65 10.11 124 131903 11893 63345102
Chest pain 99.40 10.11 186 131841 215773 63141222
Suspected suicide 99.08 10.11 93 131934 6475 63350520
Febrile neutropenia 97.55 10.11 63 131964 118386 63238609
Anticonvulsant drug level above therapeutic 97.50 10.11 38 131989 494 63356501
Exposure via breast milk 97.50 10.11 58 131969 1999 63354996
Vertigo 97.38 10.11 310 131717 59577 63297418
Bipolar I disorder 96.47 10.11 56 131971 1843 63355152
Treatment failure 95.57 10.11 167 131860 198876 63158119
Electroencephalogram abnormal 94.97 10.11 71 131956 3601 63353394
Depressed mood 94.73 10.11 238 131789 39953 63317042
Hypertension 94.68 10.11 283 131744 279020 63077975
Electrocardiogram QT prolonged 93.03 10.11 304 131723 59226 63297769
Cardiac failure congestive 92.71 10.11 38 131989 92395 63264600
Arthritis 92.31 10.11 64 131963 115857 63241138
Stillbirth 91.29 10.11 90 131937 6660 63350335
Unresponsive to stimuli 91.24 10.11 211 131816 33605 63323390
Sedation 90.62 10.11 229 131798 38580 63318415
Camptocormia 89.81 10.11 31 131996 278 63356717
Partial seizures with secondary generalisation 88.27 10.11 33 131994 380 63356615
Sleep disorder due to general medical condition, insomnia type 88.24 10.11 5 132022 52212 63304783
Mood altered 87.06 10.11 129 131898 14614 63342381
Malignant neoplasm progression 86.95 10.11 31 131996 82090 63274905
Respiratory disorder neonatal 86.09 10.11 45 131982 1200 63355795
Behaviour disorder 85.30 10.11 63 131964 3136 63353859
Gastrointestinal disorder 84.32 10.11 89 131938 131150 63225845
Gastrointestinal haemorrhage 83.66 10.11 32 131995 81144 63275851
Dizziness 83.25 10.11 1305 130722 428620 62928375
Musculoskeletal pain 81.71 10.11 45 131982 92232 63264763
Hypogammaglobulinaemia 81.54 10.11 87 131940 7068 63349927
Death 80.09 10.11 454 131573 373927 62983068
Musculoskeletal stiffness 79.76 10.11 165 131862 184453 63172542
Blood pressure increased 79.58 10.11 134 131893 161928 63195067
Hepatic enzyme increased 79.10 10.11 191 131836 202137 63154858
Mydriasis 78.47 10.11 110 131917 11846 63345149
Hallucination, auditory 78.31 10.11 114 131913 12710 63344285
Respiratory arrest 77.65 10.11 194 131833 32451 63324544
Psychomotor hyperactivity 77.39 10.11 103 131924 10560 63346435
Memory impairment 77.36 10.11 424 131603 103834 63253161
Rash macular 76.95 10.11 158 131869 23206 63333789
Therapeutic response unexpected 76.67 10.11 139 131888 18620 63338375
Small for dates baby 76.42 10.11 63 131964 3688 63353307
Mood swings 75.58 10.11 136 131891 18112 63338883
Neuropathy peripheral 75.38 10.11 75 131952 113592 63243403
Gestational diabetes 75.07 10.11 90 131937 8306 63348689
Psychomotor retardation 74.70 10.11 63 131964 3807 63353188
Hypomania 73.96 10.11 78 131949 6252 63350743
Drug abuse 73.94 10.11 323 131704 72195 63284800
C-reactive protein abnormal 73.26 10.11 6 132021 46090 63310905
Tachycardia 73.09 10.11 458 131569 117698 63239297
Pyrexia 72.95 10.11 1378 130649 469100 62887895
Psoriatic arthropathy 72.23 10.11 51 131976 91469 63265526
General physical health deterioration 71.18 10.11 200 131827 201202 63155793
Altered state of consciousness 70.91 10.11 160 131867 25070 63331925
Dystonia 70.48 10.11 113 131914 13706 63343289
Poisoning deliberate 70.36 10.11 101 131926 11117 63345878
Osteoarthritis 70.29 10.11 57 131970 95286 63261709
Mental disorder 70.22 10.11 162 131865 25757 63331238
Mental impairment 69.84 10.11 114 131913 14037 63342958
Haemoglobin decreased 68.96 10.11 123 131904 145362 63211633
Atonic seizures 67.97 10.11 31 131996 608 63356387
Fibromyalgia 67.26 10.11 42 131985 80378 63276617
Talipes 66.74 10.11 41 131986 1499 63355496
Hip arthroplasty 66.18 10.11 10 132017 47636 63309359
Inappropriate affect 65.97 10.11 34 131993 880 63356115
Rash papular 65 10.11 117 131910 15585 63341410
Muscle twitching 64.77 10.11 133 131894 19535 63337460
Neovascularisation 64.16 10.11 36 131991 1109 63355886
Chronic obstructive pulmonary disease 64.11 10.11 25 132002 62661 63294334
Sopor 63.91 10.11 142 131885 22022 63334973
Affective disorder 63.54 10.11 71 131956 6075 63350920
Bronchitis 63.48 10.11 101 131926 124834 63232161
Epileptic aura 63.37 10.11 17 132010 56 63356939
Loss of consciousness 61.68 10.11 439 131588 117682 63239313
Inappropriate antidiuretic hormone secretion 61.20 10.11 113 131914 15349 63341646
Wheezing 61.20 10.11 65 131962 95530 63261465
Balance disorder 61.06 10.11 341 131686 84081 63272914
Cerebellar syndrome 60.99 10.11 54 131973 3485 63353510
Dysmorphism 60.73 10.11 45 131982 2251 63354744
Cyanosis neonatal 60.37 10.11 25 132002 384 63356611
Agitation neonatal 60.13 10.11 27 132000 510 63356485
Patent ductus arteriosus 59.97 10.11 58 131969 4192 63352803
Hyperkalaemia 59.92 10.11 19 132008 54184 63302811
Thinking abnormal 59.81 10.11 91 131936 10552 63346443
Enanthema 59.39 10.11 25 132002 401 63356594
Rash erythematous 59.29 10.11 209 131818 42301 63314694
Restlessness 58.82 10.11 164 131863 29289 63327706
Speech disorder 58.61 10.11 202 131825 40427 63316568
Dyspnoea exertional 58.53 10.11 26 132001 60276 63296719
Euphoric mood 58.49 10.11 61 131966 4826 63352169
Brugada syndrome 58.23 10.11 24 132003 364 63356631
Trichiasis 58.04 10.11 16 132011 60 63356935
Distributive shock 57.86 10.11 36 131991 1347 63355648
Cheilitis 57.79 10.11 56 131971 4057 63352938
Hypertonia 57.52 10.11 59 131968 4578 63352417
Herpes zoster 57.49 10.11 52 131975 82410 63274585
Blood pressure systolic increased 57.27 10.11 14 132013 47383 63309612
Tic 57.19 10.11 37 131990 1483 63355512
Foetal anticonvulsant syndrome 57.05 10.11 27 132000 578 63356417
Blood cholesterol increased 56.84 10.11 67 131960 93965 63263030
Unintended pregnancy 56.50 10.11 67 131960 6112 63350883
Acute kidney injury 56.50 10.11 319 131708 263096 63093899
Pregnancy on oral contraceptive 56.47 10.11 32 131995 1005 63355990
Knee arthroplasty 56.47 10.11 21 132006 54185 63302810
Therapeutic response changed 56.24 10.11 32 131995 1013 63355982
Hallucination 55.75 10.11 244 131783 54573 63302422
Parkinsonism 55.50 10.11 87 131940 10352 63346643
Oculogyric crisis 55.36 10.11 38 131989 1683 63355312
Congenital choroid plexus cyst 55.30 10.11 22 132005 303 63356692
Asthma 54.24 10.11 115 131912 127446 63229549
Temporal lobe epilepsy 53.58 10.11 23 132004 388 63356607
Plasma cell myeloma 53.56 10.11 6 132021 35899 63321096
Eosinophilic myocarditis 53.40 10.11 26 132001 594 63356401
Drug clearance increased 53.29 10.11 17 132010 116 63356879
Oculomucocutaneous syndrome 53.29 10.11 17 132010 116 63356879
Injection site erythema 52.74 10.11 57 131970 83117 63273878
Maternal exposure during pregnancy 52.42 10.11 693 131334 219369 63137626
Cardiac failure 52.31 10.11 65 131962 89077 63267918
Dysarthria 52.03 10.11 201 131826 42510 63314485
Cerebral microhaemorrhage 51.96 10.11 17 132010 127 63356868
Skin degenerative disorder 51.78 10.11 10 132017 0 63356995
Fluid retention 51.55 10.11 30 131997 59656 63297339
Coordination abnormal 51.21 10.11 98 131929 13675 63343320
Diverticulitis 51.21 10.11 10 132017 39547 63317448
Malaise 50.71 10.11 587 131440 415367 62941628
Cerebrovascular accident 50.58 10.11 92 131935 107932 63249063
Pain in jaw 50.35 10.11 14 132013 43482 63313513
Intellectual disability 49.86 10.11 30 131997 1056 63355939
Premature baby 49.07 10.11 123 131904 20612 63336383
Human herpesvirus 6 infection 48.74 10.11 44 131983 2913 63354082
Impulsive behaviour 48.68 10.11 34 131993 1549 63355446
Pregnancy with implant contraceptive 48.37 10.11 42 131985 2641 63354354
Disorientation 48.33 10.11 186 131841 39266 63317729
Rash vesicular 47.92 10.11 52 131975 4306 63352689
Respiratory depression 47.85 10.11 95 131932 13620 63343375
Myocardial infarction 47.73 10.11 84 131943 99809 63257186
Abdominal pain 47.64 10.11 386 131641 293070 63063925
Papule 47.63 10.11 59 131968 5632 63351363
Productive cough 47.57 10.11 37 131990 63171 63293824
Mucosal disorder 47.50 10.11 38 131989 2131 63354864
Oral disorder 47.36 10.11 74 131953 8780 63348215
Dissociation 47.26 10.11 43 131984 2876 63354119
Stomatitis 46.63 10.11 141 131886 138584 63218411
Oedema peripheral 46.54 10.11 219 131808 189292 63167703
Asthenia 46.49 10.11 542 131485 383062 62973933
Paradoxical drug reaction 46.46 10.11 50 131977 4102 63352893
Hypotonia neonatal 46.07 10.11 30 131997 1216 63355779
Developmental hip dysplasia 45.81 10.11 31 131996 1341 63355654
Injection site pain 45.75 10.11 129 131898 129671 63227324
Spina bifida 45.42 10.11 26 132001 833 63356162
Mucosal erosion 45.32 10.11 32 131995 1484 63355511
Retrognathia 45.09 10.11 21 132006 433 63356562
Lip ulceration 45.07 10.11 36 131991 2014 63354981
Persecutory delusion 44.98 10.11 41 131986 2749 63354246
Apathy 44.97 10.11 72 131955 8722 63348273
Tonic convulsion 44.97 10.11 30 131997 1267 63355728
Lung disorder 44.92 10.11 38 131989 62223 63294772
Conjunctival abrasion 44.92 10.11 11 132016 22 63356973
Drug withdrawal convulsions 44.74 10.11 31 131996 1394 63355601
Logorrhoea 44.66 10.11 39 131988 2471 63354524
Photophobia 44.27 10.11 107 131920 17528 63339467
Product dispensing error 44.21 10.11 78 131949 10227 63346768
Eyelid erosion 43.95 10.11 12 132015 43 63356952
Withdrawal syndrome 43.58 10.11 115 131912 19882 63337113
Catatonia 43.36 10.11 50 131977 4427 63352568
Simple partial seizures 43.34 10.11 22 132005 551 63356444
Migraine 43.33 10.11 365 131662 102981 63254014
Treatment noncompliance 43.31 10.11 173 131854 37152 63319843
Coarctation of the aorta 43.12 10.11 22 132005 557 63356438
Hallucination, visual 43.10 10.11 112 131915 19186 63337809
Lactic acidosis 43.08 10.11 13 132014 38274 63318721
Autism spectrum disorder 42.46 10.11 25 132002 845 63356150
Coronary artery disease 42.30 10.11 8 132019 32369 63324626
Dehydration 42.17 10.11 201 131826 173153 63183842
Lymphocyte morphology abnormal 41.93 10.11 20 132007 436 63356559
Depressive symptom 41.74 10.11 47 131980 4055 63352940
Low set ears 41.54 10.11 17 132010 253 63356742
Thrombosis 41.47 10.11 44 131983 64711 63292284
Pseudolymphoma 41.41 10.11 22 132005 607 63356388
Antipsychotic drug level increased 41.34 10.11 43 131984 3392 63353603
Central nervous system lesion 41.19 10.11 77 131950 10558 63346437
Anticonvulsant drug level below therapeutic 41.08 10.11 22 132005 617 63356378
Bursitis 40.91 10.11 13 132014 37028 63319967
Vision blurred 40.86 10.11 329 131698 91595 63265400
Crying 40.86 10.11 124 131903 23219 63333776
Conjunctivitis 40.74 10.11 115 131912 20681 63336314
Microcephaly 40.67 10.11 25 132002 915 63356080
Deep vein thrombosis 40.46 10.11 70 131957 83730 63273265
Rectal haemorrhage 40.45 10.11 26 132001 49004 63307991
Loss of personal independence in daily activities 40.28 10.11 89 131938 97201 63259794
Live birth 40.13 10.11 131 131896 25499 63331496
Sepsis 39.96 10.11 173 131854 152950 63204045
Accidental exposure to product by child 39.94 10.11 27 132000 1166 63355829
Neoplasm progression 39.86 10.11 13 132014 36415 63320580
Exposure via ingestion 39.73 10.11 39 131988 2870 63354125
Osteoporosis 38.97 10.11 37 131990 57301 63299694
Gamma-glutamyltransferase increased 38.90 10.11 157 131870 33874 63323121
Blood lactate dehydrogenase increased 38.79 10.11 121 131906 22995 63334000
Drug dose titration not performed 38.55 10.11 20 132007 525 63356470
Joint range of motion decreased 38.36 10.11 10 132017 32418 63324577
Rhabdomyolysis 38.30 10.11 187 131840 43764 63313231
Hypotonia 38.19 10.11 69 131958 9216 63347779
Renal impairment 38.10 10.11 79 131948 88276 63268719
Intermenstrual bleeding 37.96 10.11 63 131964 7863 63349132
Metastases to liver 37.78 10.11 3 132024 23636 63333359
Pregnancy on contraceptive 37.59 10.11 26 132001 1166 63355829
Drug resistance 37.52 10.11 119 131908 22814 63334181
Flat affect 37.42 10.11 28 131999 1422 63355573
Pulmonary fibrosis 37.33 10.11 18 132009 39791 63317204
Paranoia 37.31 10.11 78 131949 11601 63345394
Cellulitis 37.30 10.11 71 131956 81887 63275108
Persistent genital arousal disorder 37.27 10.11 16 132011 270 63356725
Hostility 37.22 10.11 31 131996 1841 63355154
Disseminated intravascular coagulation 36.98 10.11 105 131922 18946 63338049
Red blood cell sedimentation rate increased 36.73 10.11 23 132004 43959 63313036
Macular degeneration 36.54 10.11 4 132023 24372 63332623
Hydrops foetalis 36.49 10.11 20 132007 588 63356407
Nightmare 36.49 10.11 105 131922 19089 63337906
Traumatic coma 36.42 10.11 11 132016 61 63356934
Blood pressure fluctuation 36.29 10.11 26 132001 46291 63310704
Benzodiazepine drug level increased 36.20 10.11 14 132013 178 63356817
Major depression 36.11 10.11 62 131965 7956 63349039
Epidermal necrosis 35.72 10.11 24 132003 1026 63355969
Encephalopathy 35.60 10.11 167 131860 38453 63318542
Nasal congestion 35.34 10.11 51 131976 65609 63291386
Sinus tachycardia 35.30 10.11 121 131906 24147 63332848
Abnormal palmar/plantar creases 35.19 10.11 10 132017 43 63356952
Oedema 35.16 10.11 96 131931 97526 63259469
Full blood count decreased 34.93 10.11 6 132021 26018 63330977
Libido increased 34.77 10.11 26 132001 1319 63355676
Coma scale abnormal 34.70 10.11 48 131979 5105 63351890
Concussion 34.65 10.11 66 131961 9178 63347817
Femur fracture 34.64 10.11 22 132005 41734 63315261
Angiofibroma 34.63 10.11 12 132015 109 63356886
Multiple congenital abnormalities 34.59 10.11 19 132008 561 63356434
Ureteric perforation 34.53 10.11 8 132019 11 63356984
Erythema 34.45 10.11 535 131492 175216 63181779
Drug screen false positive 34.45 10.11 22 132005 862 63356133
Nausea 34.40 10.11 1441 130586 853030 62503965
Obsessive thoughts 34.26 10.11 19 132008 572 63356423
Chest discomfort 34.00 10.11 116 131911 109853 63247142
Eosinophil percentage increased 33.76 10.11 23 132004 1006 63355989
Accessory auricle 33.75 10.11 7 132020 3 63356992
Premature labour 33.70 10.11 78 131949 12426 63344569
Stereotypy 33.52 10.11 17 132010 425 63356570
Neonatal respiratory distress syndrome 33.42 10.11 35 131992 2783 63354212
Pharyngeal erythema 33.37 10.11 28 131999 1680 63355315
Taste disorder 33.34 10.11 82 131945 13580 63343415
Poor feeding infant 33.33 10.11 16 132011 354 63356641
Constipation 33.30 10.11 303 131724 224640 63132355
Abdominal pain upper 33.27 10.11 272 131755 206172 63150823
Urinary tract infection 33.19 10.11 371 131656 264313 63092682
Acute respiratory distress syndrome 33.07 10.11 116 131911 23418 63333577
Melaena 32.93 10.11 11 132016 30354 63326641
Tubulointerstitial nephritis and uveitis syndrome 32.90 10.11 14 132013 231 63356764
Salivary hypersecretion 32.86 10.11 58 131969 7608 63349387
Lymphangioleiomyomatosis 32.68 10.11 13 132014 179 63356816
Exomphalos 32.54 10.11 18 132009 539 63356456
Basal cell carcinoma 32.42 10.11 9 132018 27982 63329013
Vomiting projectile 32.21 10.11 25 132002 1341 63355654
Placental disorder 32.19 10.11 26 132001 1478 63355517
Arnold-Chiari malformation 32.17 10.11 19 132008 646 63356349
Rapid eye movement sleep behaviour disorder 32.13 10.11 15 132012 311 63356684
Skin erosion 31.98 10.11 33 131994 2579 63354416
Hyperprolactinaemia 31.95 10.11 40 131987 3860 63353135
Gambling disorder 31.91 10.11 24 132003 1228 63355767
Decreased appetite 31.83 10.11 351 131676 250701 63106294
Postictal psychosis 31.44 10.11 8 132019 20 63356975
Photosensitivity reaction 31.44 10.11 85 131942 14909 63342086
Psychotic symptom 31.34 10.11 26 132001 1535 63355460
Osteonecrosis of jaw 31.27 10.11 17 132010 35106 63321889
Brain death 31.22 10.11 37 131990 3373 63353622
Pleural effusion 31.12 10.11 95 131932 93115 63263880
Cataract 31.02 10.11 44 131983 57009 63299986
Blood pressure diastolic decreased 31.00 10.11 5 132022 22701 63334294
Resting tremor 30.88 10.11 20 132007 803 63356192
Congenital skin dimples 30.72 10.11 11 132016 111 63356884
Transaminases increased 30.66 10.11 138 131889 31229 63325766
Purpura 30.66 10.11 71 131956 11314 63345681
Genital erosion 30.31 10.11 12 132015 163 63356832
Vestibular migraine 30.14 10.11 13 132014 222 63356773
Haemoptysis 30.13 10.11 11 132016 28715 63328280
Hemivertebra 30.12 10.11 11 132016 118 63356877
Drug withdrawal syndrome 29.93 10.11 124 131903 27070 63329925
Oesophageal atresia 29.88 10.11 17 132010 538 63356457
Blood creatinine increased 29.71 10.11 89 131938 87755 63269240
Tonsillar hypertrophy 29.62 10.11 21 132006 980 63356015
Neurotoxicity 29.50 10.11 90 131937 16900 63340095
Affect lability 29.44 10.11 69 131958 11082 63345913
Product quality issue 29.41 10.11 150 131877 35715 63321280
Acute myocardial infarction 29.41 10.11 15 132012 32109 63324886
Hyperbilirubinaemia neonatal 29.25 10.11 15 132012 384 63356611
Abortion missed 29.17 10.11 26 132001 1693 63355302
Lymphadenitis 29.11 10.11 35 131992 3240 63353755
Infantile apnoea 29.03 10.11 21 132006 1012 63355983
Vulvar erosion 28.94 10.11 12 132015 185 63356810
Weight gain poor 28.93 10.11 20 132007 896 63356099
Influenza 28.87 10.11 122 131905 108600 63248395
Renal failure 28.84 10.11 136 131891 117516 63239479
Gastroschisis 28.43 10.11 15 132012 408 63356587
Illusion 28.37 10.11 21 132006 1049 63355946
Polyhydramnios 28.36 10.11 29 131998 2242 63354753
Bradycardia neonatal 28.24 10.11 20 132007 932 63356063
Night sweats 28.21 10.11 36 131991 48778 63308217
Pulmonary oedema 28.20 10.11 44 131983 54829 63302166
Erythema of eyelid 28.20 10.11 29 131998 2257 63354738
Amnesia 28.08 10.11 205 131822 55380 63301615
Chloropsia 28.04 10.11 8 132019 35 63356960
Heart rate decreased 28.02 10.11 32 131995 45528 63311467
Drug hypersensitivity 27.94 10.11 466 131561 310221 63046774
Hypoglycaemia neonatal 27.81 10.11 20 132007 955 63356040
Lung neoplasm malignant 27.54 10.11 4 132023 19629 63337366
Inflammation 27.36 10.11 84 131943 82189 63274806
Psychomotor skills impaired 27.35 10.11 29 131998 2339 63354656
Contusion 27.33 10.11 191 131836 149853 63207142
Joint stiffness 27.32 10.11 28 131999 41841 63315154
Neoplasm malignant 27.25 10.11 14 132013 29847 63327148
Panic attack 27.12 10.11 105 131922 22226 63334769
Retinogram abnormal 27.11 10.11 11 132016 160 63356835
Pyloric stenosis 27.10 10.11 14 132013 364 63356631
Eye movement disorder 27.00 10.11 43 131984 5185 63351810
Hypomagnesaemia 26.94 10.11 13 132014 28724 63328271
Galactorrhoea 26.93 10.11 38 131989 4117 63352878
Ascites 26.84 10.11 27 132000 40701 63316294
Colitis 26.81 10.11 37 131990 48491 63308504
Ischaemic stroke 26.78 10.11 3 132024 17954 63339041
Type 2 diabetes mellitus 26.78 10.11 58 131969 63810 63293185
COVID-19 26.42 10.11 133 131894 112970 63244025
Hepatocellular injury 26.42 10.11 120 131907 27261 63329734
Aphasia 26.36 10.11 137 131890 32863 63324132
Seizure cluster 26.28 10.11 12 132015 236 63356759
Self-injurious ideation 26.27 10.11 30 131997 2629 63354366
Pregnancy with contraceptive device 26.18 10.11 40 131987 4654 63352341
Product administration error 26.13 10.11 104 131923 22293 63334702
Electrocardiogram ST segment depression 25.98 10.11 31 131996 2846 63354149
Symblepharon 25.95 10.11 9 132018 82 63356913
Metastases to bone 25.80 10.11 6 132021 21013 63335982
Dyspepsia 25.72 10.11 117 131910 102079 63254916
Skin ulcer 25.65 10.11 31 131996 43014 63313981
Urinary incontinence 25.63 10.11 133 131894 31881 63325114
Osteomyelitis 25.59 10.11 11 132016 26009 63330986
Feeling drunk 25.55 10.11 37 131990 4105 63352890
Abnormal dreams 25.54 10.11 63 131964 10453 63346542
Bradypnoea 25.31 10.11 34 131993 3516 63353479
Poor weight gain neonatal 25.30 10.11 9 132018 89 63356906
Injection site bruising 25.17 10.11 30 131997 41880 63315115
Plagiocephaly 25.03 10.11 8 132019 55 63356940
Distractibility 24.99 10.11 14 132013 430 63356565
Sternal fracture 24.97 10.11 27 132000 2227 63354768
Hepatic function abnormal 24.86 10.11 147 131880 36995 63320000
Pulmonary arterial hypertension 24.80 10.11 8 132019 22569 63334426
Anomalous pulmonary venous connection 24.78 10.11 8 132019 57 63356938
Mucosal inflammation 24.72 10.11 37 131990 46891 63310104
Haematochezia 24.70 10.11 46 131981 53498 63303497
Normal newborn 24.68 10.11 54 131973 8287 63348708
Drooling 24.51 10.11 35 131992 3833 63353162
Dysphoria 24.50 10.11 40 131987 4926 63352069
Lymphocytic infiltration 24.44 10.11 18 132009 892 63356103
Staring 24.43 10.11 23 132004 1607 63355388
Psychiatric symptom 24.33 10.11 41 131986 5182 63351813
Attention deficit hyperactivity disorder 24.32 10.11 31 131996 3045 63353950
Injection site pruritus 24.32 10.11 35 131992 45081 63311914
Developmental delay 24.31 10.11 22 132005 1461 63355534
Grip strength decreased 24.30 10.11 8 132019 22279 63334716
Persistent depressive disorder 24.29 10.11 19 132008 1031 63355964
Bone pain 24.28 10.11 48 131979 54593 63302402
Hyperammonaemia 24.28 10.11 41 131986 5191 63351804
Soft tissue injury 24.17 10.11 23 132004 1629 63355366
Learning disorder 24.13 10.11 16 132011 669 63356326
Neutropenia 24.07 10.11 240 131787 174765 63182230
Haemorrhoids 24.06 10.11 8 132019 22142 63334853
Adverse drug reaction 24.02 10.11 85 131942 79629 63277366
Congenital anomaly in offspring 24.01 10.11 10 132017 156 63356839
Derealisation 24.01 10.11 20 132007 1188 63355807
Congenital hand malformation 23.99 10.11 12 132015 291 63356704
Cerebral atrophy 23.91 10.11 40 131987 5026 63351969
Impatience 23.85 10.11 13 132014 378 63356617
Persistent left superior vena cava 23.78 10.11 7 132020 35 63356960
Cholestasis of pregnancy 23.76 10.11 20 132007 1205 63355790
Abdominal distension 23.74 10.11 96 131931 86519 63270476
Self-medication 23.69 10.11 29 131998 2734 63354261
Cerebral infarction 23.66 10.11 10 132017 23883 63333112
Creatinine renal clearance decreased 23.64 10.11 3 132024 16305 63340690
Intention tremor 23.63 10.11 13 132014 385 63356610
Nephrogenic diabetes insipidus 23.60 10.11 18 132009 941 63356054
Choroidal coloboma 23.55 10.11 5 132022 3 63356992
Ill-defined disorder 23.43 10.11 89 131938 81666 63275329
Agranulocytosis 23.39 10.11 109 131918 25025 63331970
Educational problem 23.39 10.11 13 132014 393 63356602
Hepatosplenomegaly 23.34 10.11 28 131999 2586 63354409
Cataplexy 23.33 10.11 20 132007 1236 63355759
Injury corneal 23.25 10.11 8 132019 71 63356924
Negative symptoms in schizophrenia 23.23 10.11 9 132018 115 63356880
Vanishing bile duct syndrome 23.16 10.11 16 132011 716 63356279
Lymphocyte stimulation test positive 22.96 10.11 14 132013 505 63356490
Head titubation 22.93 10.11 17 132010 851 63356144
Oral mucosal blistering 22.82 10.11 42 131985 5691 63351304
Somnambulism 22.56 10.11 41 131986 5502 63351493
Pulmonary embolism 22.51 10.11 146 131881 116538 63240457
Localised infection 22.33 10.11 18 132009 30192 63326803
Acquired immunodeficiency syndrome 22.32 10.11 8 132019 81 63356914
Sleep paralysis 22.25 10.11 15 132012 645 63356350
Palmar-plantar erythrodysaesthesia syndrome 22.21 10.11 10 132017 23005 63333990
Miosis 22.21 10.11 48 131979 7305 63349690
Cystitis 22.19 10.11 51 131976 54940 63302055
Hypocalcaemia 22.09 10.11 20 132007 31693 63325302
Coprolalia 22.09 10.11 6 132021 21 63356974
Upper gastrointestinal haemorrhage 21.95 10.11 6 132021 18846 63338149
Epstein-Barr virus infection reactivation 21.92 10.11 16 132011 782 63356213
Chronic kidney disease 21.84 10.11 38 131989 45360 63311635
Myelosuppression 21.80 10.11 11 132016 23692 63333303
Weight decreased 21.78 10.11 425 131602 276373 63080622
Gestational hypertension 21.76 10.11 26 132001 2391 63354604
Mouth ulceration 21.72 10.11 130 131897 32854 63324141
Anaphylactic shock 21.69 10.11 11 132016 23622 63333373
Irregular sleep phase 21.66 10.11 6 132021 23 63356972
Urinary retention 21.63 10.11 122 131905 30179 63326816
Flight of ideas 21.52 10.11 13 132014 461 63356534
Therapy non-responder 21.51 10.11 83 131944 75818 63281177
Interstitial lung disease 21.46 10.11 62 131965 61846 63295149
Pre-eclampsia 21.42 10.11 54 131973 9079 63347916
Drug tolerance decreased 21.42 10.11 5 132022 17468 63339527
Dissociative disorder 21.23 10.11 12 132015 375 63356620
Sciatica 21.23 10.11 24 132003 34300 63322695
Dysphemia 21.22 10.11 27 132000 2648 63354347
Angiomyolipoma 21.22 10.11 10 132017 212 63356783
Drug level changed 21.17 10.11 10 132017 213 63356782
Maternal exposure before pregnancy 21.12 10.11 48 131979 7555 63349440
Cardiac malposition 21.09 10.11 7 132020 55 63356940
SJS-TEN overlap 21.06 10.11 12 132015 381 63356614
Off label use 21.02 10.11 1168 130859 673294 62683701
Sleep-related eating disorder 21.00 10.11 16 132011 835 63356160
Congenital anomaly 20.95 10.11 22 132005 1754 63355241
Gastric ulcer 20.87 10.11 12 132015 24025 63332970
Posture abnormal 20.85 10.11 25 132002 2307 63354688
Pulmonary hypertension 20.81 10.11 28 131999 37095 63319900
Poor sucking reflex 20.79 10.11 11 132016 301 63356694
Blood creatine phosphokinase increased 20.73 10.11 121 131906 30309 63326686
Oral hairy leukoplakia 20.71 10.11 4 132023 0 63356995
Hepatotoxicity 20.70 10.11 28 131999 37013 63319982
Automatism 20.66 10.11 7 132020 59 63356936
Granulocytopenia 20.65 10.11 40 131987 5632 63351363
Cleft palate 20.62 10.11 17 132010 995 63356000
Dermatitis exfoliative 20.49 10.11 39 131988 5420 63351575
Disinhibition 20.48 10.11 16 132011 867 63356128
Illogical thinking 20.46 10.11 7 132020 61 63356934
Orthostatic hypertension 20.46 10.11 13 132014 505 63356490
Hypersomnia 20.40 10.11 83 131944 17972 63339023
Change in seizure presentation 20.24 10.11 12 132015 411 63356584
Postictal state 20.17 10.11 17 132010 1026 63355969
Myocarditis 20.13 10.11 57 131970 10268 63346727
Foot deformity 20.09 10.11 17 132010 27836 63329159
White blood cell count increased 20.07 10.11 171 131856 48390 63308605
Hereditary ataxia 20.06 10.11 6 132021 32 63356963
Dysmetria 20.03 10.11 13 132014 524 63356471
Conjunctival disorder 19.98 10.11 10 132017 243 63356752
Brain oedema 19.97 10.11 70 131957 14125 63342870
Antidepressant drug level above therapeutic 19.88 10.11 12 132015 425 63356570
Tachyphrenia 19.86 10.11 19 132008 1355 63355640
Bile acid malabsorption 19.85 10.11 9 132018 174 63356821
Impulse-control disorder 19.82 10.11 15 132012 775 63356220
Post-traumatic neck syndrome 19.81 10.11 23 132004 2051 63354944
Drug ineffective for unapproved indication 19.78 10.11 130 131897 33933 63323062
Heart rate increased 19.70 10.11 115 131912 94123 63262872
Self esteem decreased 19.64 10.11 14 132013 659 63356336
Retinal pigment epitheliopathy 19.61 10.11 10 132017 253 63356742
Psychiatric decompensation 19.54 10.11 19 132008 1382 63355613
External auditory canal atresia 19.52 10.11 7 132020 71 63356924
Drop attacks 19.47 10.11 14 132013 668 63356327
Borderline personality disorder 19.47 10.11 15 132012 796 63356199
Hospitalisation 19.33 10.11 101 131926 84980 63272015
Entropion 19.26 10.11 7 132020 74 63356921
Laryngeal ulceration 19.24 10.11 5 132022 14 63356981
Hepatic cirrhosis 19.22 10.11 14 132013 24720 63332275
Drug level fluctuating 19.17 10.11 12 132015 454 63356541
Ventricular arrhythmia 19.11 10.11 31 131996 3797 63353198
Oral mucosal eruption 19.06 10.11 14 132013 691 63356304
Tension 19.06 10.11 28 131999 3147 63353848
Sinus congestion 18.91 10.11 7 132020 18116 63338879
Upper respiratory tract infection 18.86 10.11 97 131930 81950 63275045
Bipolar II disorder 18.84 10.11 11 132016 366 63356629
Iris coloboma 18.80 10.11 6 132021 41 63356954
Lipids 18.75 10.11 5 132022 16 63356979
Anorgasmia 18.66 10.11 13 132014 590 63356405
Angina pectoris 18.64 10.11 21 132006 30057 63326938
Postmortem blood drug level 18.64 10.11 8 132019 135 63356860
Oscillopsia 18.64 10.11 8 132019 135 63356860
Increased appetite 18.61 10.11 53 131974 9577 63347418
Lipids abnormal 18.59 10.11 10 132017 283 63356712
Throat irritation 18.58 10.11 31 131996 37616 63319379
Adrenal insufficiency 18.56 10.11 7 132020 17908 63339087
Hypervolaemia 18.54 10.11 19 132008 28394 63328601
Histiocytosis 18.52 10.11 5 132022 17 63356978
Device related infection 18.49 10.11 13 132014 23379 63333616
Screaming 18.48 10.11 28 131999 3234 63353761
Congenital anaemia 18.48 10.11 4 132023 3 63356992
Lip scab 18.48 10.11 4 132023 3 63356992
Coma scale 18.44 10.11 6 132021 44 63356951
Hiatus hernia 18.44 10.11 11 132016 21583 63335412
Hypercalcaemia 18.41 10.11 19 132008 28303 63328692
Rhinorrhoea 18.40 10.11 72 131955 65505 63291490
Meningomyelocele 18.37 10.11 13 132014 605 63356390
Cerebral ventricle dilatation 18.33 10.11 16 132011 1013 63355982
Skin lesion 18.30 10.11 118 131909 30603 63326392
Brachycephaly 18.30 10.11 5 132022 18 63356977
Tricuspid valve incompetence 18.29 10.11 4 132023 14617 63342378
Bone density decreased 18.28 10.11 4 132023 14608 63342387
Overweight 18.21 10.11 30 131997 3721 63353274
Confusional state 18.21 10.11 631 131396 235749 63121246
Ejection fraction decreased 18.21 10.11 12 132015 22320 63334675
Foetal heart rate deceleration abnormality 18.20 10.11 12 132015 497 63356498
Hippocampal sclerosis 18.17 10.11 7 132020 88 63356907
Thyroiditis 18.17 10.11 24 132003 2442 63354553
Wound infection 18.15 10.11 11 132016 21399 63335596
Cerebellar ataxia 18.06 10.11 15 132012 887 63356108
Abortion 17.94 10.11 24 132003 2472 63354523
Echolalia 17.89 10.11 9 132018 221 63356774
Peripheral venous disease 17.88 10.11 5 132022 15472 63341523
Learning disability 17.82 10.11 9 132018 223 63356772
Cerebral disorder 17.81 10.11 33 131994 4493 63352502
Negativism 17.81 10.11 11 132016 406 63356589
Alanine aminotransferase increased 17.76 10.11 309 131718 103461 63253534
Homicidal ideation 17.70 10.11 20 132007 1732 63355263
Metastases to central nervous system 17.64 10.11 3 132024 13102 63343893
Dermatitis bullous 17.60 10.11 48 131979 8460 63348535
Parachute mitral valve 17.56 10.11 7 132020 97 63356898
Septic shock 17.54 10.11 75 131952 66554 63290441
Limbic encephalitis 17.45 10.11 10 132017 321 63356674
Cytomegalovirus infection 17.43 10.11 11 132016 20941 63336054
Transfusion 17.42 10.11 5 132022 15212 63341783
Haematuria 17.37 10.11 21 132006 29136 63327859
Tearfulness 17.33 10.11 31 131996 4108 63352887
Tonic clonic movements 17.33 10.11 18 132009 1417 63355578
Lymph node pain 17.30 10.11 18 132009 1420 63355575
Scab 17.28 10.11 45 131982 7718 63349277
Liver injury 17.27 10.11 66 131961 60454 63296541
Heavy menstrual bleeding 17.22 10.11 78 131949 17695 63339300
Adverse event 17.20 10.11 77 131950 67482 63289513
Suicide threat 17.15 10.11 5 132022 24 63356971
Joint effusion 17.12 10.11 7 132020 17053 63339942
Haematocrit decreased 17.10 10.11 35 131992 39305 63317690
Periodic limb movement disorder 17.05 10.11 9 132018 245 63356750
Strabismus 17.05 10.11 21 132006 1993 63355002
Viral rash 17.04 10.11 10 132017 336 63356659
Haematemesis 16.99 10.11 23 132004 30389 63326606
Macule 16.93 10.11 21 132006 2007 63354988
Platelet count decreased 16.91 10.11 157 131870 115965 63241030
Spinal stenosis 16.91 10.11 5 132022 14920 63342075
Dry skin 16.91 10.11 61 131966 56826 63300169
Premature rupture of membranes 16.72 10.11 34 131993 4959 63352036
Gait deviation 16.54 10.11 6 132021 63 63356932
Herpangina 16.51 10.11 5 132022 28 63356967
Suppressed lactation 16.48 10.11 11 132016 465 63356530
Body temperature decreased 16.45 10.11 11 132016 20308 63336687
Mononucleosis syndrome 16.42 10.11 8 132019 183 63356812
Bezoar 16.42 10.11 18 132009 1508 63355487
Menstrual disorder 16.41 10.11 35 131992 5278 63351717
Skin exfoliation 16.37 10.11 149 131878 42953 63314042
Cleft lip 16.37 10.11 7 132020 117 63356878
Lennox-Gastaut syndrome 16.32 10.11 9 132018 268 63356727
Congenital aortic valve stenosis 16.21 10.11 6 132021 67 63356928
Nodule 16.21 10.11 12 132015 21014 63335981
Multiple organ dysfunction syndrome 16.20 10.11 185 131842 56567 63300428
Head injury 16.18 10.11 105 131922 27291 63329704
Cerebellar atrophy 16.16 10.11 13 132014 735 63356260
Hypokalaemia 16.15 10.11 138 131889 103666 63253329
Congenital ureteric anomaly 16.13 10.11 6 132021 68 63356927
Hypercapnic coma 16.11 10.11 8 132019 191 63356804
Bradyphrenia 16.09 10.11 41 131986 6939 63350056
Alopecia universalis 16.05 10.11 7 132020 123 63356872
Pulmonary mass 16.04 10.11 14 132013 22582 63334413
Sleep disorder due to a general medical condition 15.95 10.11 3 132024 12185 63344810
Hepatitis 15.86 10.11 139 131888 39649 63317346
Bradykinesia 15.82 10.11 34 131993 5154 63351841
Retinal coloboma 15.82 10.11 5 132022 33 63356962
Middle insomnia 15.80 10.11 60 131967 12583 63344412
Neuropsychiatric symptoms 15.78 10.11 13 132014 760 63356235
Muscle spasms 15.78 10.11 229 131798 155921 63201074
Congenital oesophageal anomaly 15.72 10.11 4 132023 10 63356985
Peritonitis 15.72 10.11 8 132019 17146 63339849
Economic problem 15.68 10.11 20 132007 1966 63355029
Attention-seeking behaviour 15.68 10.11 6 132021 74 63356921
Blood prolactin increased 15.66 10.11 27 132000 3476 63353519
Anal erosion 15.56 10.11 5 132022 35 63356960
Corneal erosion 15.56 10.11 9 132018 294 63356701
Pharyngeal exudate 15.53 10.11 3 132024 0 63356995
Laryngeal tremor 15.53 10.11 3 132024 0 63356995
Mononucleosis heterophile test positive 15.53 10.11 3 132024 0 63356995
Cardiac aneurysm 15.52 10.11 14 132013 926 63356069
Chorea 15.50 10.11 18 132009 1606 63355389
Selective IgA immunodeficiency 15.45 10.11 4 132023 11 63356984
Morose 15.44 10.11 5 132022 36 63356959
Dysmetropsia 15.39 10.11 6 132021 78 63356917
Apnoea 15.36 10.11 44 131983 7978 63349017
Mitral valve incompetence 15.35 10.11 11 132016 19583 63337412
Injection site reaction 15.33 10.11 66 131961 58458 63298537
Hypoxia 15.31 10.11 68 131959 59724 63297271
Placental infarction 15.24 10.11 9 132018 306 63356689
Epidermolysis 15.09 10.11 12 132015 667 63356328
Speech disorder developmental 15.08 10.11 12 132015 668 63356327
Myelodysplastic syndrome 15.07 10.11 8 132019 16746 63340249
Haemangioma 14.97 10.11 23 132004 2689 63354306
Drug screen positive 14.97 10.11 27 132000 3602 63353393
Full blood count abnormal 14.85 10.11 27 132000 31690 63325305
Conjunctival ulcer 14.77 10.11 5 132022 42 63356953
Tongue biting 14.76 10.11 17 132010 1503 63355492
Conjunctival oedema 14.74 10.11 12 132015 690 63356305
Skin cancer 14.68 10.11 3 132024 11492 63345503
Spinal fracture 14.65 10.11 10 132017 18261 63338734
Flank pain 14.52 10.11 8 132019 16402 63340593
Foetal death 14.47 10.11 53 131974 10927 63346068
Vulval disorder 14.42 10.11 13 132014 859 63356136
Musculoskeletal disorder 14.40 10.11 13 132014 20631 63336364
Osteochondrosis 14.39 10.11 16 132011 1361 63355634
Delusional perception 14.36 10.11 8 132019 243 63356752
Foetal malnutrition 14.32 10.11 6 132021 95 63356900
Autoimmune disorder 14.32 10.11 9 132018 17168 63339827
Aspergillus test positive 14.32 10.11 9 132018 343 63356652
Antipsychotic drug level above therapeutic 14.28 10.11 14 132013 1029 63355966
Odynophagia 14.27 10.11 41 131986 7445 63349550
Therapeutic product effective for unapproved indication 14.27 10.11 6 132021 96 63356899
Hyperventilation 14.18 10.11 36 131991 6080 63350915
Tuberculosis 14.16 10.11 3 132024 11208 63345787
Eyelid oedema 14.16 10.11 51 131976 10428 63346567
Metabolic syndrome 14.16 10.11 17 132010 1571 63355424
Injection site swelling 14.15 10.11 51 131976 47521 63309474
Spinal compression fracture 14.11 10.11 6 132021 14277 63342718
Oral mucosal erythema 14.10 10.11 17 132010 1578 63355417
Bronchiectasis 14.10 10.11 8 132019 16134 63340861
Gout 14.06 10.11 5 132022 13266 63343729
White blood cell count decreased 14.05 10.11 204 131823 138900 63218095
Gastric disorder 14.02 10.11 36 131991 37333 63319662
Retinal pigmentation 13.99 10.11 6 132021 101 63356894
Hallucinations, mixed 13.99 10.11 31 131996 4798 63352197
Hallucination, olfactory 13.95 10.11 8 132019 257 63356738
Phonophobia 13.95 10.11 9 132018 359 63356636
Emotional disorder 13.94 10.11 60 131967 13319 63343676
Delusion of reference 13.94 10.11 6 132021 102 63356893
Musculoskeletal chest pain 13.86 10.11 14 132013 21069 63335926
Immunodeficiency 13.84 10.11 13 132014 20241 63336754
Potentiating drug interaction 13.80 10.11 29 131998 4327 63352668
Abulia 13.80 10.11 10 132017 483 63356512
Blood calcium decreased 13.79 10.11 21 132006 26430 63330565
Nervous system disorder 13.69 10.11 76 131951 18690 63338305
Eclampsia 13.64 10.11 9 132018 373 63356622
Acute myopia 13.62 10.11 6 132021 108 63356887
Exposure via transplant 13.59 10.11 4 132023 20 63356975
Acquired epidermolysis bullosa 13.58 10.11 5 132022 55 63356940
Combined immunodeficiency 13.57 10.11 6 132021 109 63356886
Lethargy 13.56 10.11 177 131850 55830 63301165
Clostridium difficile infection 13.54 10.11 26 132001 29896 63327099
Toothache 13.50 10.11 12 132015 19187 63337808
Cardiac disorder 13.50 10.11 57 131970 50759 63306236
Lactation disorder 13.47 10.11 9 132018 381 63356614
Niemann-Pick disease 13.46 10.11 3 132024 3 63356992
Congenital emphysema 13.46 10.11 3 132024 3 63356992
Pulmonary congestion 13.35 10.11 10 132017 17408 63339587
Colitis ulcerative 13.33 10.11 21 132006 26070 63330925
Social avoidant behaviour 13.32 10.11 23 132004 2965 63354030
Mucosal ulceration 13.27 10.11 13 132014 954 63356041
Walking aid user 13.27 10.11 3 132024 10714 63346281
Roseolovirus test positive 13.26 10.11 5 132022 59 63356936
Personality disorder 13.26 10.11 34 131993 5777 63351218
Lymphoid tissue hyperplasia 13.21 10.11 7 132020 192 63356803
Decreased interest 13.15 10.11 24 132003 3230 63353765
Holoprosencephaly 13.12 10.11 4 132023 23 63356972
Hypercholesterolaemia 13.10 10.11 15 132012 21319 63335676
Foetal growth restriction 13.10 10.11 40 131987 7513 63349482
Manic symptom 13 10.11 3 132024 4 63356991
Directional Doppler flow tests abnormal 13 10.11 3 132024 4 63356991
Alcohol abuse 12.99 10.11 19 132008 2127 63354868
Epilepsy surgery 12.98 10.11 4 132023 24 63356971
Juvenile myoclonic epilepsy 12.98 10.11 4 132023 24 63356971
Cellulitis orbital 12.97 10.11 10 132017 531 63356464
Injection site haemorrhage 12.97 10.11 19 132008 24295 63332700
Ventricular fibrillation 12.97 10.11 54 131973 11813 63345182
Injury 12.96 10.11 94 131933 73153 63283842
Breast cancer female 12.91 10.11 6 132021 13553 63343442
Food interaction 12.90 10.11 12 132015 826 63356169
Epidermolysis bullosa 12.87 10.11 6 132021 124 63356871
Cortical dysplasia 12.84 10.11 4 132023 25 63356970
Retroperitoneal fibrosis 12.82 10.11 8 132019 301 63356694
Polydipsia 12.81 10.11 25 132002 3539 63353456
Spinal osteoarthritis 12.79 10.11 9 132018 16177 63340818
Cogwheel rigidity 12.74 10.11 18 132009 1952 63355043
Fungal infection 12.72 10.11 37 131990 36837 63320158
Distichiasis 12.71 10.11 4 132023 26 63356969
Accidental death 12.70 10.11 18 132009 1958 63355037
Laryngitis 12.68 10.11 10 132017 16957 63340038
Brain stem syndrome 12.68 10.11 9 132018 421 63356574
Respiratory tract infection 12.65 10.11 44 131983 41439 63315556
Mental status changes 12.64 10.11 132 131895 39467 63317528
Blood pressure systolic abnormal 12.63 10.11 6 132021 13380 63343615
Cardiovascular symptom 12.63 10.11 5 132022 68 63356927
Unemployment 12.60 10.11 3 132024 5 63356990
Pneumocystis jirovecii pneumonia 12.60 10.11 10 132017 16904 63340091
Anembryonic gestation 12.59 10.11 10 132017 555 63356440
Eosinophilic pneumonia 12.56 10.11 19 132008 2192 63354803
Hirsutism 12.55 10.11 15 132012 1380 63355615
Delivery 12.48 10.11 15 132012 1388 63355607
Heart rate irregular 12.48 10.11 17 132010 22404 63334591
Neurosurgery 12.37 10.11 5 132022 72 63356923
Drug-induced liver injury 12.34 10.11 133 131894 40089 63316906
Oesophagitis 12.32 10.11 8 132019 15000 63341995
Depression suicidal 12.30 10.11 17 132010 1806 63355189
Dysphonia 12.28 10.11 54 131973 47560 63309435
Ulcerative keratitis 12.26 10.11 21 132006 2689 63354306
Wound healing normal 12.25 10.11 3 132024 6 63356989
Atrophy of globe 12.25 10.11 3 132024 6 63356989
Homeless 12.24 10.11 5 132022 74 63356921
Delusional disorder, erotomanic type 12.21 10.11 4 132023 30 63356965
Status migrainosus 12.21 10.11 6 132021 140 63356855
Anuria 12.10 10.11 55 131972 12496 63344499
Mucosa vesicle 12.10 10.11 4 132023 31 63356964
Disorganised speech 12.04 10.11 14 132013 1251 63355744
Initial insomnia 12.01 10.11 34 131993 6123 63350872
Blood pressure diastolic increased 12.01 10.11 3 132024 10007 63346988
Acute psychosis 12.00 10.11 20 132007 2505 63354490
Bankruptcy 11.99 10.11 4 132023 32 63356963
Paralogism 11.99 10.11 4 132023 32 63356963
Hypothermia 11.98 10.11 58 131969 13523 63343472
Tongue eruption 11.95 10.11 5 132022 79 63356916
Diverticulum 11.90 10.11 5 132022 11986 63345009
Lip disorder 11.89 10.11 15 132012 1459 63355536
Blood iron decreased 11.88 10.11 8 132019 14713 63342282
Tendonitis 11.82 10.11 14 132013 19601 63337394
Clumsiness 11.82 10.11 18 132009 2089 63354906
Injection site rash 11.80 10.11 13 132014 18796 63338199
Accidental overdose 11.79 10.11 86 131941 23223 63333772
Deja vu 11.78 10.11 5 132022 82 63356913
Product administration interrupted 11.77 10.11 29 131998 4807 63352188
Emotional poverty 11.72 10.11 8 132019 351 63356644
Induced labour 11.61 10.11 12 132015 939 63356056
Leukocytosis 11.61 10.11 93 131934 25842 63331153
Metastases to lung 11.60 10.11 6 132021 12744 63344251
Drowning 11.58 10.11 9 132018 484 63356511
Pityriasis rosea 11.56 10.11 5 132022 86 63356909
Transient ischaemic attack 11.54 10.11 40 131987 37713 63319282
Pigmentation disorder 11.48 10.11 28 131999 4611 63352384
Tonsillar haemorrhage 11.44 10.11 7 132020 254 63356741
Monocyte percentage increased 11.42 10.11 13 132014 1135 63355860
Blunted affect 11.39 10.11 7 132020 256 63356739
Congenital gastric anomaly 11.39 10.11 3 132024 9 63356986
Spinal cord infarction 11.37 10.11 7 132020 257 63356738
Carpal tunnel syndrome 11.37 10.11 16 132011 20801 63336194
Neutrophilia 11.34 10.11 27 132000 4379 63352616
Gastroenteritis 11.27 10.11 24 132003 26566 63330429
Liver function test increased 11.27 10.11 33 131994 32778 63324217
Cardiomegaly 11.24 10.11 12 132015 17602 63339393
Conversion disorder 11.24 10.11 16 132011 1748 63355247
Breast cancer 11.23 10.11 57 131970 48326 63308669
Anorexia nervosa 11.22 10.11 7 132020 263 63356732
Interleukin-2 receptor increased 11.20 10.11 5 132022 93 63356902
Lip haemorrhage 11.18 10.11 9 132018 509 63356486
Libido decreased 11.17 10.11 20 132007 2652 63354343
Head circumference abnormal 11.16 10.11 3 132024 10 63356985
Alexia 11.16 10.11 3 132024 10 63356985
Hyperphagia 11.13 10.11 16 132011 1763 63355232
Gastritis 11.09 10.11 40 131987 37263 63319732
Medication overuse headache 11.08 10.11 11 132016 821 63356174
Teratogenicity 11.06 10.11 7 132020 270 63356725
Flashback 11.05 10.11 6 132021 173 63356822
Clostridium difficile colitis 11.04 10.11 16 132011 20553 63336442
Anticonvulsant drug level abnormal 10.95 10.11 4 132023 43 63356952
Blood magnesium decreased 10.88 10.11 7 132020 13191 63343804
Nikolsky's sign 10.87 10.11 5 132022 100 63356895
Alcoholism 10.87 10.11 16 132011 1802 63355193
Malignant melanoma 10.85 10.11 5 132022 11351 63345644
Substance abuse 10.84 10.11 28 131999 4779 63352216
Colitis microscopic 10.82 10.11 3 132024 9336 63347659
Violence-related symptom 10.80 10.11 8 132019 400 63356595
Stupor 10.79 10.11 26 132001 4249 63352746
Lymphoma 10.70 10.11 6 132021 12181 63344814
Skin disorder 10.70 10.11 101 131926 29406 63327589
Disease recurrence 10.70 10.11 97 131930 27933 63329062
Visual field defect 10.69 10.11 34 131993 6527 63350468
Lymphocytosis 10.67 10.11 20 132007 2747 63354248
Ideas of reference 10.65 10.11 5 132022 105 63356890
Blood glucose increased 10.63 10.11 117 131910 83639 63273356
Cytotoxic oedema 10.63 10.11 6 132021 187 63356808
Open globe injury 10.63 10.11 4 132023 47 63356948
Myalgia 10.61 10.11 228 131799 146301 63210694
Drug withdrawal syndrome neonatal 10.59 10.11 17 132010 2064 63354931
Sinus disorder 10.54 10.11 22 132005 24531 63332464
Malabsorption 10.53 10.11 25 132002 4047 63352948
Dermatosis 10.53 10.11 7 132020 294 63356701
Palpitations 10.49 10.11 168 131859 112602 63244393
Hyperglycaemia 10.49 10.11 48 131979 41819 63315176
Breast cancer metastatic 10.43 10.11 6 132021 12012 63344983
Perinatal depression 10.36 10.11 10 132017 721 63356274
Tourette's disorder 10.36 10.11 3 132024 14 63356981
Body height decreased 10.33 10.11 4 132023 10074 63346921
Prolonged labour 10.30 10.11 9 132018 571 63356424
Psychogenic seizure 10.27 10.11 15 132012 1677 63355318
Blood loss anaemia 10.23 10.11 3 132024 8998 63347997
Vasoplegia syndrome 10.22 10.11 15 132012 1684 63355311
Corneal opacity 10.22 10.11 10 132017 733 63356262
Decreased nasolabial fold 10.19 10.11 3 132024 15 63356980
Therapy interrupted 10.18 10.11 34 131993 32421 63324574
Muscular weakness 10.18 10.11 186 131841 122167 63234828
Diabetes insipidus 10.16 10.11 19 132008 2606 63354389
Bone disorder 10.12 10.11 18 132009 21308 63335687

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1432.23 12.09 1359 66641 103498 34785433
Foetal exposure during pregnancy 1054.03 12.09 746 67254 37355 34851576
Stevens-Johnson syndrome 675.81 12.09 432 67568 18207 34870724
Completed suicide 601.38 12.09 842 67158 97326 34791605
Generalised tonic-clonic seizure 508.63 12.09 381 67619 20793 34868138
Drug reaction with eosinophilia and systemic symptoms 487.56 12.09 448 67552 32564 34856367
Status epilepticus 443.86 12.09 287 67713 12327 34876604
Product substitution issue 408.59 12.09 251 67749 9844 34879087
Toxicity to various agents 404.80 12.09 1071 66929 199291 34689640
Aggression 393.10 12.09 430 67570 38534 34850397
Epilepsy 392.10 12.09 329 67671 21166 34867765
Ataxia 370.40 12.09 266 67734 13587 34875344
Exposure during pregnancy 318.53 12.09 205 67795 8729 34880202
Atrial septal defect 261.99 12.09 169 67831 7223 34881708
Suicide attempt 235.16 12.09 333 67667 38783 34850148
Toxic epidermal necrolysis 232.40 12.09 247 67753 21399 34867532
Agitation 230.41 12.09 406 67594 56993 34831938
Febrile neutropenia 223.87 12.09 10 67990 136839 34752092
Drug level increased 221.22 12.09 243 67757 21853 34867078
Diarrhoea 217.68 12.09 264 67736 389648 34499283
Somnolence 210.62 12.09 581 67419 110535 34778396
Dyspnoea 204.10 12.09 261 67739 376521 34512410
Rash 194.99 12.09 903 67097 221849 34667082
Intentional overdose 191.07 12.09 321 67679 43353 34845578
Partial seizures 181.54 12.09 114 67886 4646 34884285
Mania 176.29 12.09 147 67853 9364 34879567
Abnormal behaviour 173.37 12.09 228 67772 24741 34864190
Drug interaction 171.89 12.09 880 67120 225066 34663865
Death 171.30 12.09 322 67678 397727 34491204
Pneumonia 168.96 12.09 279 67721 362348 34526583
Anaemia 168.50 12.09 125 67875 233210 34655721
Multiple-drug resistance 166.73 12.09 112 67888 5127 34883804
Exposure via breast milk 165.43 12.09 80 67920 1930 34887001
Irritability 163.05 12.09 220 67780 24470 34864461
Hypospadias 159.34 12.09 91 67909 3110 34885821
Sudden unexplained death in epilepsy 146.21 12.09 49 67951 429 34888502
Brugada syndrome 146.16 12.09 56 67944 745 34888186
Acute kidney injury 138.83 12.09 238 67762 304750 34584181
Autism spectrum disorder 127.13 12.09 70 67930 2226 34886705
Patent ductus arteriosus 127.08 12.09 80 67920 3274 34885657
Coma 127.07 12.09 277 67723 45401 34843530
Maternal exposure during pregnancy 123.60 12.09 91 67909 4827 34884104
Infantile apnoea 122.82 12.09 52 67948 909 34888022
Maternal exposure during breast feeding 122.81 12.09 60 67940 1481 34887450
Cardiac failure congestive 121.56 12.09 11 67989 83259 34805672
Overdose 120.18 12.09 420 67580 90639 34798292
Myocardial infarction 119.69 12.09 43 67957 121042 34767889
Respiratory disorder neonatal 116.68 12.09 59 67941 1571 34887360
Drug withdrawal syndrome neonatal 116.68 12.09 78 67922 3541 34885390
Ventricular septal defect 116.57 12.09 81 67919 3920 34885011
Petit mal epilepsy 115.58 12.09 73 67927 3005 34885926
Dysmorphism 113.90 12.09 73 67927 3083 34885848
Maternal drugs affecting foetus 112.55 12.09 79 67921 3886 34885045
Rash maculo-papular 112.45 12.09 200 67800 28251 34860680
Suicidal ideation 111.28 12.09 244 67756 40144 34848787
Focal dyscognitive seizures 110.75 12.09 54 67946 1327 34887604
Drug eruption 108.74 12.09 162 67838 19736 34869195
Neonatal respiratory distress syndrome 106.72 12.09 77 67923 3957 34884974
Malignant neoplasm progression 106.37 12.09 21 67979 88025 34800906
Myoclonus 106.14 12.09 137 67863 14588 34874343
Atrial fibrillation 105.71 12.09 53 67947 122340 34766591
Arthralgia 105.66 12.09 105 67895 169936 34718995
Attention deficit hyperactivity disorder 104.45 12.09 64 67936 2495 34886436
Congenital anomaly 104.36 12.09 52 67948 1341 34887590
Hypomania 104.03 12.09 62 67938 2297 34886634
Psychomotor hyperactivity 98.32 12.09 107 67893 9515 34879416
Speech disorder developmental 97.48 12.09 58 67942 2142 34886789
Developmental delay 97.22 12.09 63 67937 2712 34886219
Cognitive disorder 96.25 12.09 188 67812 28505 34860426
Conjunctival hyperaemia 95.31 12.09 59 67941 2343 34886588
Selective eating disorder 95.14 12.09 53 67947 1725 34887206
Disease progression 94.53 12.09 46 67954 108031 34780900
Oral mucosa erosion 93.24 12.09 43 67957 929 34888002
Pain 89.98 12.09 163 67837 204512 34684419
Lip erosion 89.98 12.09 37 67963 599 34888332
Oculogyric crisis 89.60 12.09 49 67951 1537 34887394
Intentional self-injury 88.30 12.09 121 67879 13650 34875281
Cardiac failure 87.46 12.09 34 67966 91214 34797717
Electrocardiogram QRS complex prolonged 87.30 12.09 74 67926 4820 34884111
Hypotonia neonatal 85.65 12.09 45 67955 1300 34887631
Obsessive-compulsive disorder 84.94 12.09 77 67923 5487 34883444
Bradycardia neonatal 83.82 12.09 40 67960 936 34887995
Sepsis 83.14 12.09 122 67878 166439 34722492
Neonatal infection 82.76 12.09 31 67969 386 34888545
Interstitial lung disease 82.21 12.09 14 67986 65268 34823663
Haemophagocytic lymphohistiocytosis 81.69 12.09 113 67887 12860 34876071
Crying 81.50 12.09 77 67923 5785 34883146
Agitation neonatal 79.42 12.09 40 67960 1056 34887875
Accidental exposure to product by child 78.98 12.09 44 67956 1432 34887499
Electroencephalogram abnormal 76.51 12.09 52 67948 2426 34886505
Tremor 75.04 12.09 339 67661 82248 34806683
Neurodevelopmental disorder 74.22 12.09 29 67971 408 34888523
Abdominal pain 73.95 12.09 128 67872 163490 34725441
Cough 73.92 12.09 111 67889 150029 34738902
Aura 73.66 12.09 27 67973 315 34888616
Neuroleptic malignant syndrome 72.05 12.09 127 67873 17807 34871124
Postictal psychosis 70.66 12.09 23 67977 182 34888749
Premature baby 69.96 12.09 132 67868 19501 34869430
Pain in extremity 69.87 12.09 86 67914 126427 34762504
Anger 69.62 12.09 100 67900 11784 34877147
Disturbance in attention 69.47 12.09 155 67845 25790 34863141
Bipolar disorder 68.59 12.09 57 67943 3612 34885319
Anticonvulsant drug level above therapeutic 68.02 12.09 31 67969 651 34888280
Oedema peripheral 67.69 12.09 80 67920 119732 34769199
Pulmonary embolism 67.35 12.09 46 67954 89700 34799231
Excessive eye blinking 67.32 12.09 29 67971 530 34888401
Joint swelling 66.85 12.09 17 67983 59873 34829058
Restlessness 66.85 12.09 151 67849 25331 34863600
Balance disorder 66.63 12.09 202 67798 40452 34848479
Psychotic disorder 66.50 12.09 147 67853 24305 34864626
Coronary artery disease 66.31 12.09 8 67992 48297 34840634
Neonatal tachypnoea 66.15 12.09 21 67979 152 34888779
Gaze palsy 65.27 12.09 41 67959 1671 34887260
Gastrointestinal haemorrhage 64.22 12.09 47 67953 88430 34800501
Back pain 63.93 12.09 86 67914 121703 34767228
Nystagmus 63.77 12.09 61 67939 4654 34884277
Tardive dyskinesia 61.98 12.09 66 67934 5724 34883207
Blood prolactin increased 61.76 12.09 40 67960 1720 34887211
Haemoglobin decreased 61.67 12.09 87 67913 120685 34768246
Talipes 60.92 12.09 41 67959 1882 34887049
Sedation 59.07 12.09 128 67872 20878 34868053
Acute myocardial infarction 58.53 12.09 16 67984 53703 34835228
Neuropathy peripheral 58.16 12.09 46 67954 83217 34805714
Dystonia 57.39 12.09 87 67913 10758 34878173
Conjunctivitis 57.34 12.09 82 67918 9623 34879308
General physical health deterioration 57.33 12.09 101 67899 128168 34760763
Pleural effusion 57.03 12.09 45 67955 81501 34807430
Partial seizures with secondary generalisation 56.02 12.09 22 67978 314 34888617
Hypoplastic left heart syndrome 55.70 12.09 20 67980 219 34888712
Infusion related reaction 55.60 12.09 17 67983 53040 34835891
Infection 55.42 12.09 57 67943 90858 34798073
Hallucination, auditory 55.30 12.09 90 67910 11827 34877104
Depression 54.96 12.09 350 67650 96748 34792183
Neutropenia 54.63 12.09 142 67858 156636 34732295
Platelet count decreased 53.74 12.09 94 67906 119623 34769308
Mydriasis 53.19 12.09 68 67932 7169 34881762
Weight decreased 53.17 12.09 171 67829 176130 34712801
Behaviour disorder 52.61 12.09 56 67944 4854 34884077
Apathy 52.32 12.09 66 67934 6866 34882065
Antipsychotic drug level increased 52.27 12.09 50 67950 3815 34885116
Overweight 52.12 12.09 37 67963 1853 34887078
Bipolar I disorder 52.03 12.09 27 67973 760 34888171
Off label use 52.00 12.09 544 67456 418980 34469951
Tubulointerstitial nephritis and uveitis syndrome 51.77 12.09 15 67985 76 34888855
Psychomotor retardation 50.84 12.09 48 67952 3602 34885329
Psychogenic seizure 50.67 12.09 21 67979 347 34888584
Ascites 50.49 12.09 14 67986 46557 34842374
COVID-19 50.30 12.09 46 67954 77504 34811427
Blister 49.75 12.09 126 67874 22732 34866199
Neonatal behavioural syndrome 49.67 12.09 16 67984 122 34888809
Erythema multiforme 49.52 12.09 72 67928 8577 34880354
Dyskinesia 49.26 12.09 124 67876 22289 34866642
Asthenia 49.23 12.09 278 67722 244973 34643958
Learning disorder 48.96 12.09 29 67971 1062 34887869
Peripheral swelling 48.94 12.09 46 67954 76495 34812436
Renal impairment 48.32 12.09 68 67932 94445 34794486
Anomaly of external ear congenital 48.18 12.09 15 67985 101 34888830
Anticonvulsant drug level increased 47.74 12.09 33 67967 1583 34887348
Mood altered 47.63 12.09 72 67928 8880 34880051
Hypertension 47.20 12.09 124 67876 136319 34752612
Poisoning 47.07 12.09 85 67915 12141 34876790
Nausea 47.02 12.09 429 67571 339479 34549452
Therapeutic response unexpected 45.69 12.09 74 67926 9683 34879248
Thinking abnormal 45.64 12.09 58 67942 6079 34882852
Chronic obstructive pulmonary disease 45.59 12.09 19 67981 48899 34840032
Cleft palate 45.16 12.09 23 67977 622 34888309
Dyspnoea exertional 45.11 12.09 14 67986 43265 34845666
Accidental overdose 44.86 12.09 112 67888 20028 34868903
Prostate cancer 44.74 12.09 11 67989 39638 34849293
Poisoning deliberate 44.48 12.09 65 67935 7779 34881152
Hypotonia 44.42 12.09 65 67935 7788 34881143
Foetal anticonvulsant syndrome 44.19 12.09 28 67972 1159 34887772
Hyperkalaemia 44.01 12.09 42 67958 69347 34819584
Abulia 43.77 12.09 22 67978 578 34888353
Respiratory failure 43.69 12.09 91 67909 108481 34780450
Mucosal disorder 43.51 12.09 32 67968 1694 34887237
Staring 43.38 12.09 30 67970 1440 34887491
Cerebrovascular accident 43.37 12.09 61 67939 84750 34804181
Plasma cell myeloma 43.10 12.09 14 67986 42023 34846908
Dysarthria 42.87 12.09 157 67843 34625 34854306
Respiratory acidosis 42.84 12.09 51 67949 4999 34883932
Hypotension 41.94 12.09 256 67744 221393 34667538
Retinal pigment epitheliopathy 41.68 12.09 16 67984 214 34888717
Delusion 41.40 12.09 82 67918 12553 34876378
Renal failure 41.19 12.09 124 67876 130433 34758498
Strabismus 41.19 12.09 31 67969 1700 34887231
Dyspraxia 40.88 12.09 19 67981 418 34888513
Haemorrhage 40.33 12.09 25 67975 51345 34837586
Microcephaly 40.21 12.09 23 67977 788 34888143
Eyelid erosion 39.41 12.09 8 67992 3 34888928
Fatigue 39.09 12.09 498 67502 370155 34518776
Nasal septum disorder 38.94 12.09 11 67989 50 34888881
Diplopia 38.93 12.09 95 67905 16748 34872183
Anticonvulsant drug level decreased 38.77 12.09 25 67975 1067 34887864
Memory impairment 38.70 12.09 177 67823 43141 34845790
Deep vein thrombosis 38.53 12.09 42 67958 65206 34823725
Epistaxis 38.43 12.09 34 67966 58217 34830714
Arthropathy 38.07 12.09 4 67996 26903 34862028
Herpes zoster 37.93 12.09 10 67990 34389 34854542
Logorrhoea 37.87 12.09 34 67966 2392 34886539
Altered state of consciousness 37.73 12.09 114 67886 22779 34866152
Wrong schedule 37.69 12.09 14 67986 170 34888761
Haematochezia 37.44 12.09 22 67978 46512 34842419
Septic shock 37.39 12.09 51 67949 71783 34817148
Abdominal pain upper 36.96 12.09 51 67949 71439 34817492
Speech disorder 36.91 12.09 122 67878 25564 34863367
Arthritis 36.75 12.09 8 67992 31338 34857593
Decreased appetite 36.46 12.09 183 67817 166209 34722722
Coarctation of the aorta 36.38 12.09 18 67982 457 34888474
Polydactyly 36.37 12.09 25 67975 1188 34887743
Motor developmental delay 35.98 12.09 20 67980 648 34888283
Intentional product use issue 35.88 12.09 38 67962 59778 34829153
Congenital diaphragmatic hernia 35.75 12.09 15 67985 256 34888675
Atonic seizures 35.70 12.09 15 67985 257 34888674
Chest pain 35.42 12.09 127 67873 126635 34762296
Tonic clonic movements 35.37 12.09 23 67977 996 34887935
Drug titration error 35.30 12.09 18 67982 488 34888443
Pneumonitis 35.23 12.09 11 67989 33867 34855064
Blood creatine phosphokinase increased 34.80 12.09 176 67824 44681 34844250
Anxiety 34.65 12.09 320 67680 99108 34789823
Rash morbilliform 34.49 12.09 36 67964 3051 34885880
Rash erythematous 34.44 12.09 117 67883 24860 34864071
Tic 34.43 12.09 30 67970 2028 34886903
Cardiac septal hypertrophy 34.33 12.09 15 67985 284 34888647
Body dysmorphic disorder 33.96 12.09 12 67988 125 34888806
Delirium 33.71 12.09 172 67828 43819 34845112
Educational problem 33.52 12.09 18 67982 544 34888387
Productive cough 33.17 12.09 16 67984 37797 34851134
Parasomnia 33.00 12.09 16 67984 388 34888543
Angina pectoris 32.94 12.09 10 67990 31353 34857578
Encephalopathy 32.80 12.09 146 67854 35173 34853758
Postictal paralysis 32.79 12.09 14 67986 250 34888681
Drug resistance 32.77 12.09 118 67882 25809 34863122
Pulmonary hypoplasia 32.71 12.09 17 67983 480 34888451
Suspiciousness 32.53 12.09 15 67985 324 34888607
Personality disorder 32.52 12.09 23 67977 1145 34887786
Burnout syndrome 32.36 12.09 12 67988 145 34888786
Major depression 32.10 12.09 42 67958 4530 34884401
Catatonia 31.98 12.09 44 67956 4981 34883950
Chapped lips 31.97 12.09 18 67982 598 34888333
Change in seizure presentation 31.85 12.09 12 67988 152 34888779
Retrognathia 31.76 12.09 14 67986 271 34888660
Limb reduction defect 31.48 12.09 14 67986 277 34888654
Neonatal respiratory arrest 31.42 12.09 8 67992 22 34888909
Bicuspid aortic valve 31.41 12.09 13 67987 214 34888717
Anticonvulsant drug level below therapeutic 31.15 12.09 18 67982 629 34888302
Cardio-respiratory arrest 31.09 12.09 199 67801 55074 34833857
Paranoia 31.07 12.09 71 67929 11997 34876934
Face oedema 31.04 12.09 69 67931 11447 34877484
Rectal haemorrhage 31.03 12.09 20 67980 40229 34848702
Upper gastrointestinal haemorrhage 30.98 12.09 6 67994 25512 34863419
Affect lability 30.92 12.09 37 67963 3646 34885285
Chills 30.87 12.09 70 67930 80973 34807958
Angular cheilitis 30.83 12.09 12 67988 167 34888764
Cryptorchism 30.67 12.09 28 67972 2013 34886918
Insomnia 30.64 12.09 323 67677 103584 34785347
Feelings of worthlessness 30.25 12.09 14 67986 305 34888626
SJS-TEN overlap 30.21 12.09 14 67986 306 34888625
Colitis 30.15 12.09 18 67982 37732 34851199
Epidermal necrosis 30.05 12.09 16 67984 475 34888456
Haematuria 29.81 12.09 32 67968 50034 34838897
Intellectual disability 29.72 12.09 23 67977 1315 34887616
Depressive symptom 29.56 12.09 32 67968 2827 34886104
Illusion 29.52 12.09 19 67981 808 34888123
Haemangioma congenital 29.25 12.09 16 67984 502 34888429
Psychomotor skills impaired 29.18 12.09 37 67963 3869 34885062
Eye discharge 29.13 12.09 27 67973 1979 34886952
Depressed level of consciousness 29.07 12.09 162 67838 42679 34846252
Hypomagnesaemia 29.06 12.09 4 67996 21847 34867084
Affective disorder 28.99 12.09 39 67961 4321 34884610
Serotonin syndrome 28.93 12.09 95 67905 19838 34869093
Hallucination, visual 28.76 12.09 88 67912 17703 34871228
Developmental regression 28.76 12.09 8 67992 34 34888897
Convulsive threshold lowered 28.68 12.09 16 67984 522 34888409
Cytokine release syndrome 28.58 12.09 5 67995 22872 34866059
Eosinophil percentage increased 28.19 12.09 16 67984 540 34888391
Sinus tachycardia 28.18 12.09 86 67914 17274 34871657
Myoclonic epilepsy 28.15 12.09 21 67979 1136 34887795
Suspected suicide 27.87 12.09 40 67960 4708 34884223
Hypernatraemia 27.69 12.09 55 67945 8435 34880496
Gait disturbance 27.66 12.09 270 67730 84870 34804061
Haemoptysis 27.52 12.09 17 67983 34989 34853942
Tongue movement disturbance 27.41 12.09 10 67990 115 34888816
Psychiatric symptom 27.39 12.09 34 67966 3479 34885452
Musculoskeletal pain 27.32 12.09 14 67986 31949 34856982
Lichen spinulosus 27.32 12.09 6 67994 6 34888925
Mental disorder 27.22 12.09 78 67922 15131 34873800
Erythema of eyelid 27.22 12.09 19 67981 926 34888005
Derealisation 27.13 12.09 16 67984 581 34888350
Cardiogenic shock 27.04 12.09 9 67991 26609 34862322
Heart rate decreased 26.99 12.09 14 67986 31731 34857200
Cataplexy 26.90 12.09 13 67987 313 34888618
Cerebral ventricle dilatation 26.84 12.09 19 67981 947 34887984
Pancytopenia 26.80 12.09 95 67905 95062 34793869
Dysmetria 26.76 12.09 16 67984 596 34888335
Hypertonia 26.75 12.09 37 67963 4209 34884722
Mucosal erosion 26.75 12.09 18 67982 826 34888105
Posture abnormal 26.62 12.09 27 67973 2212 34886719
Kidney malformation 26.59 12.09 11 67989 181 34888750
Apnoea 26.51 12.09 47 67953 6617 34882314
Cleft lip 26.49 12.09 13 67987 324 34888607
Hypoglycaemia neonatal 26.48 12.09 25 67975 1876 34887055
Skin erosion 26.37 12.09 26 67974 2059 34886872
Enanthema 26.35 12.09 14 67986 414 34888517
Pilonidal cyst congenital 26.34 12.09 7 67993 24 34888907
Cytomegalovirus infection 26.27 12.09 9 67991 26126 34862805
Temperature regulation disorder 25.96 12.09 17 67983 745 34888186
Syncope 25.95 12.09 91 67909 91360 34797571
Lymphadenopathy 25.93 12.09 117 67883 28346 34860585
Confusional state 25.91 12.09 409 67591 143751 34745180
Renal aplasia 25.88 12.09 17 67983 749 34888182
Drug level decreased 25.80 12.09 51 67949 7795 34881136
Mental impairment 25.77 12.09 60 67940 10262 34878669
Plagiocephaly 25.73 12.09 15 67985 533 34888398
Lung disorder 25.72 12.09 18 67982 34678 34854253
Suicide threat 25.70 12.09 7 67993 27 34888904
Caesarean section 25.55 12.09 26 67974 2138 34886793
Pulmonary oedema 25.48 12.09 33 67967 47496 34841435
Cleft lip and palate 25.48 12.09 18 67982 894 34888037
Large for dates baby 25.38 12.09 18 67982 900 34888031
Pulmonary fibrosis 25.36 12.09 3 67997 18393 34870538
Tonic convulsion 25.28 12.09 20 67980 1181 34887750
Drooling 25.20 12.09 32 67968 3350 34885581
Chest discomfort 25.19 12.09 42 67958 54488 34834443
Wheezing 25.16 12.09 26 67974 41376 34847555
Irregular sleep phase 25.07 12.09 8 67992 59 34888872
Lethargy 24.97 12.09 151 67849 40971 34847960
Hyperexplexia 24.93 12.09 7 67993 31 34888900
Mucosal inflammation 24.92 12.09 23 67977 38599 34850332
Disorientation 24.89 12.09 129 67871 33059 34855872
Restless legs syndrome 24.74 12.09 52 67948 8302 34880629
Hyperhomocysteinaemia 24.72 12.09 11 67989 218 34888713
Epispadias 24.71 12.09 10 67990 155 34888776
Salivary hypersecretion 24.67 12.09 53 67947 8591 34880340
Nasopharyngitis 24.62 12.09 63 67937 69905 34819026
Schizophrenia 24.58 12.09 53 67947 8613 34880318
Myelosuppression 24.53 12.09 4 67996 19261 34869670
Gout 24.51 12.09 4 67996 19249 34869682
Madarosis 24.36 12.09 11 67989 226 34888705
Tachyphrenia 24.31 12.09 20 67980 1249 34887682
Contraindicated product administered 24.15 12.09 6 67994 21475 34867456
Drug screen false positive 23.99 12.09 16 67984 723 34888208
Altered pitch perception 23.98 12.09 6 67994 15 34888916
Congenital melanocytic naevus 23.98 12.09 6 67994 15 34888916
Peripheral circulatory failure 23.87 12.09 10 67990 170 34888761
Pyloric stenosis 23.84 12.09 17 67983 857 34888074
Neurological decompensation 23.60 12.09 29 67971 2937 34885994
Lung neoplasm malignant 23.58 12.09 3 67997 17392 34871539
Cerebral infarction 23.50 12.09 12 67988 27443 34861488
Neoplasm progression 23.46 12.09 8 67992 23292 34865639
Gambling disorder 23.45 12.09 22 67978 1638 34887293
Constipation 23.43 12.09 163 67837 136819 34752112
Disturbance in social behaviour 23.25 12.09 23 67977 1828 34887103
Blood pressure fluctuation 23.21 12.09 10 67990 25239 34863692
Bacteraemia 23.18 12.09 5 67995 19712 34869219
Bipolar II disorder 22.94 12.09 6 67994 19 34888912
Melaena 22.91 12.09 21 67979 35359 34853572
Language disorder 22.89 12.09 25 67975 2231 34886700
Wrong patient received product 22.83 12.09 27 67973 2627 34886304
False positive investigation result 22.82 12.09 13 67987 442 34888489
Developmental coordination disorder 22.81 12.09 10 67990 191 34888740
Ischaemic stroke 22.78 12.09 4 67996 18246 34870685
Transferrin increased 22.77 12.09 5 67995 5 34888926
Abdominal distension 22.70 12.09 50 67950 58442 34830489
Spina bifida 22.52 12.09 12 67988 357 34888574
Sopor 22.46 12.09 63 67937 12073 34876858
Distributive shock 22.44 12.09 19 67981 1235 34887696
Oral disorder 22.36 12.09 34 67966 4215 34884716
Emotional disorder 22.33 12.09 40 67960 5676 34883255
Intelligence test abnormal 22.27 12.09 6 67994 22 34888909
Parkinsonism 22.20 12.09 49 67951 8089 34880842
Osteonecrosis of jaw 22.15 12.09 4 67996 17885 34871046
Movement disorder 22.10 12.09 63 67937 12185 34876746
Depersonalisation/derealisation disorder 22.08 12.09 14 67986 580 34888351
Congenital hand malformation 22.06 12.09 14 67986 581 34888350
Thrombocytopenia 22.04 12.09 196 67804 156051 34732880
Coordination abnormal 21.97 12.09 47 67953 7597 34881334
Muscle rigidity 21.87 12.09 57 67943 10461 34878470
Congenital genital malformation male 21.86 12.09 5 67995 7 34888924
Exposure via ingestion 21.84 12.09 24 67976 2157 34886774
Abdominal discomfort 21.73 12.09 53 67947 59782 34829149
Cheilitis 21.70 12.09 25 67975 2366 34886565
Postictal state 21.69 12.09 16 67984 851 34888080
Blood creatinine increased 21.62 12.09 103 67897 94873 34794058
Blood pressure increased 21.58 12.09 93 67907 88009 34800922
Pyramidal tract syndrome 21.52 12.09 10 67990 220 34888711
Compulsive shopping 21.50 12.09 12 67988 392 34888539
Drug withdrawal convulsions 21.41 12.09 18 67982 1159 34887772
Psoriatic arthropathy 21.37 12.09 6 67994 19792 34869139
Influenza 21.36 12.09 40 67960 49626 34839305
Erythema 21.23 12.09 265 67735 88515 34800416
Akathisia 21.20 12.09 48 67952 8061 34880870
Depressed mood 21.17 12.09 84 67916 19233 34869698
Hepatic cirrhosis 21.16 12.09 4 67996 17310 34871621
Cerebral haemorrhage 21.16 12.09 22 67978 34915 34854016
Cardiac disorder 21.07 12.09 32 67968 43094 34845837
Mucosal exfoliation 20.98 12.09 4 67996 0 34888931
Skin malformation 20.98 12.09 4 67996 0 34888931
Aphasia 20.92 12.09 90 67910 21364 34867567
Treatment noncompliance 20.91 12.09 109 67891 27991 34860940
Product dispensing error 20.89 12.09 41 67959 6233 34882698
Hyperbilirubinaemia neonatal 20.85 12.09 15 67985 767 34888164
Laryngomalacia 20.83 12.09 11 67989 321 34888610
Dyslexia 20.77 12.09 11 67989 323 34888608
Feeling drunk 20.72 12.09 22 67978 1901 34887030
Hypoxia 20.64 12.09 48 67952 55047 34833884
Muscle twitching 20.59 12.09 55 67945 10243 34878688
Blood glucose increased 20.57 12.09 64 67936 66654 34822277
Hyperglycaemia 20.57 12.09 28 67972 39452 34849479
Withdrawal syndrome 20.50 12.09 62 67938 12393 34876538
Product use in unapproved indication 20.49 12.09 139 67861 117360 34771571
Myalgia 20.47 12.09 89 67911 84021 34804910
Opsoclonus myoclonus 20.43 12.09 7 67993 66 34888865
Wrong product administered 20.42 12.09 37 67963 5297 34883634
Impulsive behaviour 20.29 12.09 23 67977 2139 34886792
Multiple congenital abnormalities 20.24 12.09 13 67987 551 34888380
Bundle branch block right 20.22 12.09 45 67955 7471 34881460
Aplasia cutis congenita 20.19 12.09 8 67992 117 34888814
Drug ineffective 20.17 12.09 1083 66917 455668 34433263
Mental status changes 20.12 12.09 135 67865 37948 34850983
Sinusitis 19.96 12.09 31 67969 41371 34847560
Diverticulitis 19.91 12.09 7 67993 19997 34868934
Vesicoureteric reflux 19.84 12.09 9 67991 187 34888744
Mood swings 19.80 12.09 46 67954 7855 34881076
Blood potassium increased 19.76 12.09 4 67996 16491 34872440
Gangrene neonatal 19.62 12.09 9 67991 192 34888739
Distractibility 19.60 12.09 11 67989 363 34888568
International normalised ratio increased 19.59 12.09 39 67961 47288 34841643
Congenital cerebral cyst 19.57 12.09 5 67995 14 34888917
Epileptic aura 19.57 12.09 5 67995 14 34888917
Suicidal behaviour 19.55 12.09 19 67981 1478 34887453
Peritonitis 19.54 12.09 4 67996 16361 34872570
Pneumocystis jirovecii pneumonia 19.44 12.09 7 67993 19703 34869228
Ear disorder 19.40 12.09 20 67980 1670 34887261
Bladder cancer 19.40 12.09 4 67996 16274 34872657
Deja vu 19.32 12.09 5 67995 15 34888916
Transverse presentation 19.23 12.09 7 67993 80 34888851
Anal atresia 19.06 12.09 10 67990 288 34888643
Obsessive thoughts 19.04 12.09 14 67986 741 34888190
Inappropriate schedule of product administration 19.03 12.09 60 67940 62236 34826695
Papule 18.85 12.09 31 67969 4108 34884823
Potter's syndrome 18.85 12.09 5 67995 17 34888914
Developmental hip dysplasia 18.84 12.09 10 67990 295 34888636
Cross sensitivity reaction 18.75 12.09 18 67982 1379 34887552
Scab 18.74 12.09 33 67967 4621 34884310
Single umbilical artery 18.65 12.09 9 67991 216 34888715
Skin degenerative disorder 18.63 12.09 5 67995 18 34888913
Joint laxity 18.61 12.09 11 67989 401 34888530
Full blood count decreased 18.58 12.09 6 67994 18082 34870849
Persecutory delusion 18.58 12.09 24 67976 2556 34886375
Fluid retention 18.58 12.09 15 67985 26872 34862059
Teratogenicity 18.49 12.09 6 67994 47 34888884
Clostridium difficile colitis 18.47 12.09 4 67996 15726 34873205
Feeling jittery 18.25 12.09 30 67970 3973 34884958
Coma scale abnormal 18.23 12.09 30 67970 3978 34884953
Bone marrow failure 18.20 12.09 18 67982 29235 34859696
Dyspepsia 18.19 12.09 27 67973 36705 34852226
Clostridium difficile infection 18.16 12.09 7 67993 18891 34870040
Congenital eyelid malformation 18.08 12.09 7 67993 96 34888835
Hypercalcaemia 18.02 12.09 4 67996 15464 34873467
Cerebellar atrophy 18 12.09 12 67988 542 34888389
Pustule 17.94 12.09 12 67988 545 34888386
Snoring 17.92 12.09 27 67973 3319 34885612
Dehydration 17.90 12.09 164 67836 129805 34759126
Neonatal disorder 17.86 12.09 14 67986 816 34888115
Weight decrease neonatal 17.85 12.09 10 67990 329 34888602
Brain malformation 17.82 12.09 8 67992 162 34888769
Muscle tone disorder 17.77 12.09 8 67992 163 34888768
Localised infection 17.77 12.09 6 67994 17581 34871350
Bone pain 17.77 12.09 9 67991 20677 34868254
Respiratory arrest 17.68 12.09 104 67896 27939 34860992
Subacute cutaneous lupus erythematosus 17.56 12.09 15 67985 987 34887944
Mouth ulceration 17.49 12.09 57 67943 11853 34877078
Myocardial ischaemia 17.49 12.09 6 67994 17402 34871529
Oral mucosal erythema 17.45 12.09 11 67989 451 34888480
Oculomucocutaneous syndrome 17.42 12.09 8 67992 171 34888760
Blood urea increased 17.42 12.09 20 67980 30344 34858587
Hyperreflexia 17.36 12.09 26 67974 3180 34885751
Tongue eruption 17.32 12.09 4 67996 6 34888925
Meningeal disorder 17.32 12.09 10 67990 349 34888582
Thrombosis 17.31 12.09 46 67954 50412 34838519
Increased appetite 17.27 12.09 42 67958 7387 34881544
Genital erosion 17.26 12.09 9 67991 256 34888675
Hypothermia 17.22 12.09 53 67947 10695 34878236
Temporal lobe epilepsy 17.21 12.09 8 67992 176 34888755
Hypermobility syndrome 17.16 12.09 10 67990 355 34888576
Hypokalaemia 17.14 12.09 57 67943 58157 34830774
Enuresis 17.12 12.09 22 67978 2331 34886600
Metastases to liver 17.04 12.09 3 67997 13660 34875271
Chronic kidney disease 17.02 12.09 34 67966 41176 34847755
Ocular hyperaemia 16.99 12.09 55 67945 11397 34877534
Fallot's tetralogy 16.93 12.09 8 67992 183 34888748
Hyperkinesia 16.92 12.09 19 67981 1749 34887182
Acute hepatic failure 16.89 12.09 63 67937 14011 34874920
Blood pressure systolic increased 16.89 12.09 12 67988 22940 34865991
Congenital astigmatism 16.85 12.09 6 67994 64 34888867
Acute coronary syndrome 16.83 12.09 3 67997 13542 34875389
Skin exfoliation 16.82 12.09 101 67899 27331 34861600
Lip oedema 16.81 12.09 23 67977 2590 34886341
Prostatic specific antigen increased 16.70 12.09 4 67996 14676 34874255
Product name confusion 16.69 12.09 6 67994 66 34888865
Newborn persistent pulmonary hypertension 16.66 12.09 7 67993 120 34888811
Renal disorder 16.65 12.09 15 67985 25465 34863466
Positive end-expiratory pressure 16.60 12.09 4 67996 8 34888923
Mental disability 16.53 12.09 6 67994 68 34888863
Eyelid oedema 16.48 12.09 33 67967 5091 34883840
Tongue biting 16.44 12.09 14 67986 917 34888014
Cataract 16.42 12.09 16 67984 26170 34862761
Foetal distress syndrome 16.35 12.09 15 67985 1085 34887846
Thrombocytopenia neonatal 16.29 12.09 10 67990 391 34888540
Differential white blood cell count abnormal 16.27 12.09 17 67983 1442 34887489
Cellulitis 16.17 12.09 51 67949 52900 34836031
Hepatotoxicity 16.12 12.09 11 67989 21474 34867457
Acute respiratory failure 16.04 12.09 22 67978 30906 34858025
Dysgraphia 16.04 12.09 21 67979 2266 34886665
Small for dates baby 16.01 12.09 28 67972 3899 34885032
Economic problem 15.98 12.09 16 67984 1291 34887640
Pulmonary valve stenosis congenital 15.90 12.09 7 67993 135 34888796
Intraventricular haemorrhage neonatal 15.85 12.09 9 67991 304 34888627
Torticollis 15.74 12.09 15 67985 1139 34887792
Metabolic myopathy 15.73 12.09 3 67997 0 34888931
Encephalocele 15.73 12.09 3 67997 0 34888931
Rubella 15.73 12.09 3 67997 0 34888931
Chordee 15.71 12.09 6 67994 79 34888852
Monorchidism 15.46 12.09 4 67996 12 34888919
Congenital muscle absence 15.42 12.09 5 67995 39 34888892
Congenital vas deferens absence 15.42 12.09 5 67995 39 34888892
Transaminases increased 15.34 12.09 97 67903 26726 34862205
Cerebellar syndrome 15.33 12.09 21 67979 2367 34886564
Pulmonary hypertension 15.32 12.09 11 67989 20913 34868018
Vagal nerve stimulator implantation 15.22 12.09 4 67996 13 34888918
Neoplasm malignant 15.19 12.09 10 67990 19895 34869036
Hypertelorism 15.15 12.09 11 67989 571 34888360
Drop attacks 15.13 12.09 11 67989 572 34888359
Hypothermia neonatal 15.07 12.09 6 67994 89 34888842
Circadian rhythm sleep disorder 15.05 12.09 10 67990 449 34888482
Appendicitis 15.05 12.09 5 67995 14802 34874129
Congenital genital malformation 14.94 12.09 7 67993 157 34888774
Asterixis 14.90 12.09 15 67985 1218 34887713
Hyperphagia 14.84 12.09 16 67984 1407 34887524
Agoraphobia 14.83 12.09 8 67992 244 34888687
Subgaleal haematoma 14.83 12.09 6 67994 93 34888838
Anaphylactic reaction 14.80 12.09 25 67975 32276 34856655
Idiopathic generalised epilepsy 14.70 12.09 5 67995 46 34888885
Judgement impaired 14.65 12.09 11 67989 601 34888330
Conversion disorder 14.64 12.09 9 67991 353 34888578
Aspergillus infection 14.62 12.09 3 67997 12251 34876680
Fontanelle bulging 14.57 12.09 4 67996 16 34888915
Visual field defect 14.57 12.09 29 67971 4454 34884477
Congenital scoliosis 14.54 12.09 6 67994 98 34888833
Prominent epicanthal folds 14.51 12.09 7 67993 168 34888763
Delusional perception 14.51 12.09 7 67993 168 34888763
Congenital central nervous system anomaly 14.49 12.09 11 67989 611 34888320
Skin turgor decreased 14.44 12.09 10 67990 481 34888450
Limited symptom panic attack 14.42 12.09 5 67995 49 34888882
Dysphoria 14.41 12.09 20 67980 2282 34886649
Hepatocellular injury 14.41 12.09 83 67917 22128 34866803
Oesophagitis 14.34 12.09 4 67996 13257 34875674
Conjunctival irritation 14.27 12.09 6 67994 103 34888828
Sweat gland disorder 14.27 12.09 6 67994 103 34888828
Cerebral atrophy 14.26 12.09 29 67971 4523 34884408
Moaning 14.25 12.09 12 67988 774 34888157
Caudal regression syndrome 14.24 12.09 5 67995 51 34888880
Sleep disorder 14.22 12.09 108 67892 31580 34857351
Rash macular 14.19 12.09 56 67944 12786 34876145
Maternal exposure before pregnancy 14.19 12.09 12 67988 779 34888152
Congenital inguinal hernia 14.17 12.09 7 67993 177 34888754
Extrapyramidal disorder 14.10 12.09 56 67944 12824 34876107
Transient tachypnoea of the newborn 14.03 12.09 7 67993 181 34888750
Peripheral artery thrombosis 14.03 12.09 20 67980 2340 34886591
Essential tremor 14.02 12.09 12 67988 792 34888139
Loss of employment 14.01 12.09 10 67990 505 34888426
Nasal disorder 13.99 12.09 18 67982 1910 34887021
Tooth malformation 13.92 12.09 7 67993 184 34888747
Viral rash 13.91 12.09 6 67994 110 34888821
Urinary tract infection 13.90 12.09 101 67899 83980 34804951
Postmature baby 13.85 12.09 4 67996 20 34888911
Somnolence neonatal 13.85 12.09 4 67996 20 34888911
Grimacing 13.70 12.09 8 67992 285 34888646
Arthropod sting 13.69 12.09 10 67990 524 34888407
Angina unstable 13.60 12.09 3 67997 11650 34877281
Epidermolysis 13.58 12.09 8 67992 290 34888641
Frequent bowel movements 13.57 12.09 4 67996 12783 34876148
Double outlet right ventricle 13.53 12.09 6 67994 118 34888813
Swelling 13.51 12.09 40 67960 42326 34846605
Automatism 13.48 12.09 6 67994 119 34888812
Heart disease congenital 13.41 12.09 15 67985 1375 34887556
Heart rate irregular 13.39 12.09 7 67993 15800 34873131
Drug intolerance 13.32 12.09 65 67935 59505 34829426
Product quality issue 13.32 12.09 67 67933 16968 34871963
Abortion induced 13.25 12.09 6 67994 124 34888807
Hyperthermia 13.24 12.09 48 67952 10529 34878402
Euphoric mood 13.23 12.09 32 67968 5609 34883322
Renal tubular necrosis 13.20 12.09 7 67993 15673 34873258
Hypoxic-ischaemic encephalopathy 13.18 12.09 28 67972 4504 34884427
Dermatitis allergic 13.18 12.09 36 67964 6794 34882137
Rash papular 13.17 12.09 47 67953 10231 34878700
Congenital knee deformity 13.17 12.09 6 67994 126 34888805
Gastric ulcer 13.16 12.09 7 67993 15643 34873288
Retinogram abnormal 13.12 12.09 6 67994 127 34888804
Exomphalos 13.11 12.09 7 67993 209 34888722
Congenital aortic atresia 13.10 12.09 4 67996 25 34888906
Colitis ulcerative 13.02 12.09 8 67992 16512 34872419
Obstructive airways disorder 12.92 12.09 7 67993 15487 34873444
Symblepharon 12.83 12.09 6 67994 134 34888797
Nephritis allergic 12.80 12.09 9 67991 444 34888487
Presyncope 12.71 12.09 11 67989 19048 34869883
Ligament laxity 12.59 12.09 4 67996 29 34888902
Meconium in amniotic fluid 12.59 12.09 4 67996 29 34888902
Persistent depressive disorder 12.58 12.09 8 67992 333 34888598
Decreased interest 12.58 12.09 19 67981 2341 34886590
Eosinophil count increased 12.57 12.09 41 67959 8531 34880400
Low set ears 12.51 12.09 9 67991 460 34888471
Strabismus congenital 12.48 12.09 4 67996 30 34888901
Human herpesvirus 7 infection 12.45 12.09 3 67997 6 34888925
Small fontanelle 12.45 12.09 3 67997 6 34888925
Congenital spinal cord anomaly 12.45 12.09 3 67997 6 34888925
Aortic valve atresia 12.45 12.09 3 67997 6 34888925
Assisted delivery 12.45 12.09 3 67997 6 34888925
Coronary artery occlusion 12.44 12.09 3 67997 10959 34877972
Hypervolaemia 12.41 12.09 12 67988 19697 34869234
Pericardial effusion 12.34 12.09 18 67982 24644 34864287
Injection site pain 12.31 12.09 37 67963 38968 34849963
Learning disability 12.31 12.09 8 67992 346 34888585
Adrenal insufficiency 12.23 12.09 6 67994 14041 34874890
Psychotic symptom 12.22 12.09 16 67984 1727 34887204
Hospitalisation 12.20 12.09 63 67937 56839 34832092
Blunted affect 12.19 12.09 8 67992 352 34888579
Laboratory test abnormal 12.17 12.09 13 67987 20378 34868553
Physical assault 12.16 12.09 13 67987 1132 34887799
Bronchiolitis 12.12 12.09 22 67978 3154 34885777
Live birth 12.10 12.09 7 67993 245 34888686
Congenital myopia 12.10 12.09 5 67995 82 34888849

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2842.14 10.60 2583 152272 186251 79403282
Drug reaction with eosinophilia and systemic symptoms 2256.96 10.60 1458 153397 62786 79526747
Completed suicide 2164.03 10.60 2520 152335 243247 79346286
Stevens-Johnson syndrome 1693.95 10.60 1015 153840 38151 79551382
Toxicity to various agents 1585.57 10.60 2888 151967 418652 79170881
Intentional overdose 1116.15 10.60 1195 153660 104765 79484768
Generalised tonic-clonic seizure 1102.72 10.60 811 154044 43099 79546434
Epilepsy 882.94 10.60 690 154165 40170 79549363
Toxic epidermal necrolysis 770.31 10.60 661 154194 43920 79545613
Suicide attempt 745.02 10.60 861 153994 82071 79507462
Ataxia 721.55 10.60 503 154352 24536 79564997
Status epilepticus 695.90 10.60 492 154363 24549 79564984
Aggression 602.91 10.60 612 154243 50346 79539187
Drug interaction 601.56 10.60 1971 152884 413212 79176321
Product substitution issue 581.47 10.60 406 154449 19850 79569683
Drug level increased 572.02 10.60 531 154324 39120 79550413
Overdose 527.12 10.60 1128 153727 183078 79406455
Somnolence 510.62 10.60 1305 153550 237676 79351857
Exposure during pregnancy 490.51 10.60 778 154077 100354 79489179
Suicidal ideation 456.87 10.60 648 154207 75692 79513841
Agitation 446.70 10.60 740 154115 98975 79490558
Intentional self-injury 434.77 10.60 417 154438 32002 79557531
Nystagmus 405.50 10.60 248 154607 9656 79579877
Coma 399.60 10.60 708 154147 99941 79489592
Rash maculo-papular 371.49 10.60 500 154355 55578 79533955
Mania 355.11 10.60 290 154565 17970 79571563
Dyspnoea 354.97 10.60 707 154148 856318 78733215
Diarrhoea 340.63 10.60 755 154100 879734 78709799
Petit mal epilepsy 337.93 10.60 182 154673 5545 79583988
Rash 328.55 10.60 2081 152774 576277 79013256
Arthralgia 325.72 10.60 379 154476 571424 79018109
Pneumonia 308.57 10.60 505 154350 659741 78929792
Irritability 308.52 10.60 390 154465 40754 79548779
Tremor 298.05 10.60 864 153991 169219 79420314
Joint swelling 283.70 10.60 103 154752 288543 79300990
Multiple-drug resistance 282.26 10.60 189 154666 8619 79580914
Focal dyscognitive seizures 277.90 10.60 136 154719 3376 79586157
Infusion related reaction 275.26 10.60 56 154799 230181 79359352
Partial seizures 271.85 10.60 186 154669 8792 79580741
Rheumatoid arthritis 265.83 10.60 43 154812 208427 79381106
Lymphadenopathy 261.26 10.60 412 154443 52835 79536698
Abnormal behaviour 260.10 10.60 337 154518 36084 79553449
Pain 256.86 10.60 622 154233 703180 78886353
Febrile neutropenia 256.57 10.60 66 154789 230933 79358600
Synovitis 249.20 10.60 10 154845 150724 79438809
Sudden unexplained death in epilepsy 246.95 10.60 79 154776 589 79588944
Arthropathy 246.02 10.60 28 154827 177083 79412450
Serotonin syndrome 239.98 10.60 362 154493 44665 79544868
Anaemia 238.39 10.60 309 154546 444706 79144827
Electrocardiogram QRS complex prolonged 238.33 10.60 185 154670 10648 79578885
Haemophagocytic lymphohistiocytosis 227.27 10.60 245 154610 21592 79567941
Obsessive-compulsive disorder 226.36 10.60 142 154713 5785 79583748
Oral mucosa erosion 224.80 10.60 98 154757 1849 79587684
Drug eruption 219.77 10.60 343 154512 43592 79545941
Peripheral swelling 214.36 10.60 129 154726 269488 79320045
Myoclonus 210.22 10.60 264 154591 27396 79562137
Contraindicated product administered 208.85 10.60 29 154826 157509 79432024
Abortion spontaneous 207.54 10.60 271 154584 29236 79560297
Brugada syndrome 202.81 10.60 80 154775 1158 79588375
Diplopia 201.46 10.60 285 154570 33181 79556352
Pain in extremity 192.17 10.60 256 154599 364282 79225251
Anticonvulsant drug level decreased 183.93 10.60 85 154770 1849 79587684
Poisoning 183.82 10.60 236 154619 25036 79564497
Depression 182.44 10.60 869 153986 215921 79373612
Neuroleptic malignant syndrome 175.29 10.60 241 154614 27318 79562215
Lip erosion 175.18 10.60 77 154778 1483 79588050
Disturbance in attention 174.61 10.60 336 154519 50465 79539068
Atrial fibrillation 172.84 10.60 84 154771 197802 79391731
Cardio-respiratory arrest 171.75 10.60 532 154323 107978 79481555
Nasopharyngitis 169.73 10.60 146 154709 253735 79335798
Hand deformity 168.10 10.60 8 154847 103911 79485622
Pemphigus 166.65 10.60 6 154849 99576 79489957
Psychotic disorder 165.15 10.60 292 154563 41110 79548423
Conjunctival hyperaemia 164.20 10.60 104 154751 4309 79585224
Erythema multiforme 162.93 10.60 186 154669 17465 79572068
Anticonvulsant drug level above therapeutic 161.96 10.60 67 154788 1104 79588429
Cognitive disorder 161.71 10.60 394 154461 69532 79520001
Disease progression 159.89 10.60 79 154776 184283 79405250
Cardiac failure congestive 159.37 10.60 40 154815 142362 79447171
Anticonvulsant drug level increased 158.45 10.60 85 154770 2568 79586965
Tardive dyskinesia 157.09 10.60 144 154711 10427 79579106
Bipolar disorder 155.32 10.60 125 154730 7582 79581951
Myoclonic epilepsy 155.01 10.60 76 154779 1894 79587639
Anxiety 154.87 10.60 917 153938 247595 79341938
Acute kidney injury 153.02 10.60 508 154347 518896 79070637
Swelling 151.82 10.60 119 154736 216592 79372941
Oculogyric crisis 149.96 10.60 85 154770 2867 79586666
Malignant neoplasm progression 148.75 10.60 40 154815 135950 79453583
Abdominal discomfort 148.06 10.60 161 154694 250566 79338967
Psychomotor hyperactivity 146.22 10.60 172 154683 16677 79572856
Rash morbilliform 146.21 10.60 110 154745 6040 79583493
Electroencephalogram abnormal 142.25 10.60 103 154752 5331 79584202
Infection 140.75 10.60 157 154698 241555 79347978
Aura 137.44 10.60 56 154799 886 79588647
Depressed level of consciousness 136.72 10.60 456 154399 96196 79493337
Foetal exposure during pregnancy 136.41 10.60 103 154752 5687 79583846
Hyperreflexia 136.00 10.60 120 154735 8265 79581268
Anti-cyclic citrullinated peptide antibody positive 135.78 10.60 6 154849 83137 79506396
Sinusitis 134.86 10.60 109 154746 195392 79394141
Myocardial infarction 134.23 10.60 97 154758 184032 79405501
Back pain 132.24 10.60 243 154612 303937 79285596
Muscle rigidity 131.18 10.60 177 154678 19705 79569828
Cough 131.18 10.60 327 154528 366462 79223071
Extrapyramidal disorder 128.96 10.60 188 154667 22491 79567042
Gastrointestinal haemorrhage 127.01 10.60 64 154791 147655 79441878
Bipolar I disorder 126.56 10.60 68 154787 2061 79587472
Face oedema 126.11 10.60 209 154646 27927 79561606
Suspected suicide 124.96 10.60 127 154728 10449 79579084
Cardiac failure 121.71 10.60 75 154780 154767 79434766
Clonus 121.28 10.60 103 154752 6737 79582796
Hypomania 118.45 10.60 106 154749 7438 79582095
Mydriasis 117.83 10.60 158 154697 17485 79572048
Accidental exposure to product by child 116.53 10.60 72 154783 2854 79586679
Mood altered 116.41 10.60 158 154697 17689 79571844
Hypertension 116.07 10.60 298 154557 330694 79258839
Poisoning deliberate 115.76 10.60 162 154693 18666 79570867
Vertigo 115.18 10.60 345 154510 68737 79520796
Akathisia 114.47 10.60 135 154720 13124 79576409
Partial seizures with secondary generalisation 114.12 10.60 44 154811 597 79588936
Lower respiratory tract infection 114.10 10.60 54 154801 129166 79460367
Helicobacter infection 113.92 10.60 5 154850 69699 79519834
Dyskinesia 112.95 10.60 261 154594 44512 79545021
Pleurothotonus 110.72 10.60 66 154789 2450 79587083
Intentional product use issue 109.73 10.60 81 154774 152031 79437502
Hallucination, auditory 109.71 10.60 166 154689 20527 79569006
Dystonia 109.70 10.60 169 154686 21230 79568303
Depressed mood 108.72 10.60 270 154585 48210 79541323
Anger 107.51 10.60 149 154706 17013 79572520
Arthritis 106.15 10.60 45 154810 114835 79474698
Sepsis 106.10 10.60 228 154627 269200 79320333
Neuropathy peripheral 104.87 10.60 73 154782 141232 79448301
Delusion 104.28 10.60 161 154694 20262 79569271
Duodenal ulcer perforation 104.24 10.60 6 154849 66205 79523328
Balance disorder 102.54 10.60 422 154433 98435 79491098
Altered state of consciousness 102.45 10.60 248 154607 43574 79545959
Eosinophilia 102.17 10.60 253 154602 45092 79544441
Death 101.49 10.60 664 154191 565850 79023683
Chest pain 100.63 10.60 252 154603 282052 79307481
Behaviour disorder 99.71 10.60 89 154766 6224 79583309
Haemoglobin decreased 99.59 10.60 174 154681 221945 79367588
Electrocardiogram QT prolonged 99.45 10.60 393 154462 89993 79499540
Drug level decreased 99.29 10.60 131 154724 14271 79575262
Blood pressure increased 98.97 10.60 161 154694 211199 79378334
Cross sensitivity reaction 98.63 10.60 71 154784 3641 79585892
Fatigue 98.36 10.60 1246 153609 928481 78661052
Meningitis aseptic 98.35 10.60 92 154763 6836 79582697
Drug intolerance 97.89 10.60 231 154624 263888 79325645
Toxic skin eruption 97.77 10.60 164 154691 22129 79567404
Suicidal behaviour 97.66 10.60 67 154788 3180 79586353
Cardiac arrest 97 10.60 619 154236 171477 79418056
Atonic seizures 95.91 10.60 41 154814 736 79588797
Wound 94.49 10.60 54 154801 116125 79473408
Abortion induced 94.44 10.60 91 154764 7018 79582515
Thinking abnormal 94.29 10.60 122 154733 13039 79576494
Dysarthria 93.80 10.60 317 154538 67305 79522228
General physical health deterioration 93.27 10.60 252 154603 274986 79314547
Rash erythematous 93.00 10.60 285 154570 57484 79532049
Respiratory arrest 92.73 10.60 284 154571 57266 79532267
Oedema peripheral 92.42 10.60 222 154633 252066 79337467
Hyperkalaemia 91.86 10.60 54 154801 114344 79475189
Hyperthermia 91.83 10.60 142 154713 17895 79571638
Impaired healing 91.75 10.60 28 154827 87627 79501906
Mobility decreased 90.81 10.60 63 154792 122112 79467421
Sopor 90.59 10.60 199 154656 32811 79556722
Discomfort 90.46 10.60 67 154788 125550 79463983
Therapeutic product effect decreased 90.44 10.60 111 154744 163752 79425781
Herpes zoster 90.02 10.60 34 154821 93049 79496484
Musculoskeletal pain 90.01 10.60 43 154812 102311 79487222
Restlessness 89.95 10.60 245 154610 46247 79543286
Maternal exposure during breast feeding 89.80 10.60 60 154795 2725 79586808
Distributive shock 89.33 10.60 59 154796 2628 79586905
Coronary artery disease 89.27 10.60 11 154844 65463 79524070
Rash macular 88.30 10.60 182 154673 28717 79560816
Chronic obstructive pulmonary disease 86.36 10.60 29 154826 85390 79504143
Memory impairment 86.10 10.60 437 154418 111297 79478236
Dyspnoea exertional 85.56 10.60 31 154824 87042 79502491
Infarction 85.37 10.60 71 154784 4511 79585022
Mental disorder 85.11 10.60 188 154667 31114 79558419
Conjunctivitis 84.59 10.60 167 154688 25548 79563985
Apathy 81.79 10.60 113 154742 12864 79576669
Tubulointerstitial nephritis and uveitis syndrome 81.77 10.60 29 154826 306 79589227
Ascites 81.16 10.60 23 154832 75539 79513994
Blepharospasm 79.81 10.60 76 154779 5775 79583758
Sedation 78.90 10.60 251 154604 51644 79537889
Postictal psychosis 78.79 10.60 24 154831 149 79589384
Parkinsonism 78.12 10.60 126 154729 16458 79573075
Camptocormia 78.07 10.60 31 154824 457 79589076
Dizziness 76.54 10.60 1441 153414 525000 79064533
Abdominal pain 76.22 10.60 444 154411 389125 79200408
Alopecia 75.99 10.60 215 154640 231140 79358393
Glossodynia 75.85 10.60 54 154801 103283 79486250
Mental impairment 75.57 10.60 134 154721 18902 79570631
Acute myocardial infarction 74.72 10.60 28 154827 77008 79512525
Hypogammaglobulinaemia 74.56 10.60 108 154747 12843 79576690
Sinus tachycardia 73.91 10.60 197 154658 36711 79552822
Catatonia 73.69 10.60 88 154767 8668 79580865
Epileptic aura 72.96 10.60 19 154836 59 79589474
Crying 72.62 10.60 147 154708 22896 79566637
Cerebrovascular accident 72.02 10.60 119 154736 155173 79434360
C-reactive protein abnormal 71.44 10.60 6 154849 48361 79541172
Interstitial lung disease 71.31 10.60 68 154787 112532 79477001
Renal impairment 71.24 10.60 123 154732 157660 79431873
Asthenia 71.19 10.60 643 154212 511046 79078487
Encephalopathy 70.89 10.60 289 154566 67108 79522425
Psychomotor retardation 70.77 10.60 73 154782 6111 79583422
Cerebellar syndrome 70.64 10.60 69 154786 5411 79584122
Rectal haemorrhage 70.30 10.60 30 154825 76270 79513263
Antipsychotic drug level increased 69.41 10.60 71 154784 5886 79583647
Eyelid erosion 69.09 10.60 18 154837 56 79589477
Blood pressure systolic increased 69.02 10.60 22 154833 66964 79522569
Irritable bowel syndrome 68.62 10.60 18 154837 62223 79527310
Cheilitis 68.38 10.60 67 154788 5274 79584259
Pericarditis 68.31 10.60 61 154794 104175 79485358
Gaze palsy 67.58 10.60 52 154803 2953 79586580
Unresponsive to stimuli 67.46 10.60 250 154605 55538 79533995
Folliculitis 67.10 10.60 13 154842 55367 79534166
Major depression 67.09 10.60 85 154770 8895 79580638
Dehydration 66.72 10.60 252 154603 247935 79341598
Papule 66.58 10.60 77 154778 7330 79582203
Overweight 66.52 10.60 59 154796 4091 79585442
Exposure via ingestion 66.42 10.60 65 154790 5109 79584424
Tic 65.69 10.60 51 154804 2935 79586598
Plasma cell myeloma 65.60 10.60 12 154843 53247 79536286
Sleep disorder due to general medical condition, insomnia type 65.46 10.60 5 154850 43551 79545982
Productive cough 65.04 10.60 46 154809 88285 79501248
Pleural effusion 64.89 10.60 114 154741 145148 79444385
Hallucination, visual 64.84 10.60 174 154681 32555 79556978
Systemic lupus erythematosus 64.82 10.60 84 154771 121065 79468468
Blood prolactin increased 64.25 10.60 57 154798 3954 79585579
Mood swings 64.06 10.60 128 154727 19752 79569781
Oral disorder 63.76 10.60 88 154767 10007 79579526
Neovascularisation 63.65 10.60 36 154819 1209 79588324
Wheezing 63.34 10.60 80 154775 116584 79472949
Gastrointestinal disorder 63.08 10.60 87 154768 122118 79467415
Mucosal disorder 62.29 10.60 53 154802 3475 79586058
Rash papular 62.28 10.60 134 154721 21782 79567751
Treatment noncompliance 62.18 10.60 233 154622 52035 79537498
Muscle twitching 62.05 10.60 144 154711 24620 79564913
Retinal pigment epitheliopathy 61.79 10.60 26 154829 448 79589085
Bronchitis 60.68 10.60 100 154755 130544 79458989
Paranoia 60.10 10.60 123 154732 19309 79570224
Speech disorder 60.09 10.60 237 154618 54208 79535325
Temporal lobe epilepsy 59.93 10.60 25 154830 421 79589112
Depressive symptom 59.81 10.60 68 154787 6355 79583178
Muscle injury 59.69 10.60 11 154844 48550 79540983
Drug screen false positive 59.23 10.60 33 154822 1076 79588457
Euphoric mood 59.10 10.60 74 154781 7652 79581881
Trichiasis 59.05 10.60 17 154838 84 79589449
Neutropenia 58.89 10.60 323 154532 287387 79302146
Pyrexia 58.58 10.60 1728 153127 676981 78912552
Logorrhoea 58.22 10.60 56 154799 4309 79585224
Fluid retention 57.40 10.60 32 154823 69777 79519756
Hypersensitivity 57.25 10.60 288 154567 261951 79327582
Learning disorder 56.79 10.60 26 154829 553 79588980
Deep vein thrombosis 56.67 10.60 92 154763 120827 79468706
Lung disorder 56.66 10.60 44 154811 80513 79509020
Haemoptysis 56.62 10.60 19 154836 55980 79533553
Loss of consciousness 56.58 10.60 536 154319 167407 79422126
Abulia 56.25 10.60 31 154824 989 79588544
Psoriatic arthropathy 55.63 10.60 42 154813 77957 79511576
Haematochezia 55.41 10.60 53 154802 87592 79501941
Confusional state 54.92 10.60 895 153960 317102 79272431
Blood pressure fluctuation 54.89 10.60 31 154824 67114 79522419
Affective disorder 54.78 10.60 74 154781 8245 79581288
Anticonvulsant drug level below therapeutic 54.57 10.60 31 154824 1050 79588483
Decreased appetite 54.50 10.60 415 154440 342003 79247530
Exposure via breast milk 54.18 10.60 30 154825 966 79588567
Cataplexy 53.20 10.60 29 154826 905 79588628
COVID-19 52.89 10.60 145 154710 157529 79432004
Osteoarthritis 52.67 10.60 55 154800 87254 79502279
Speech disorder developmental 52.66 10.60 26 154829 658 79588875
Coma scale abnormal 52.35 10.60 74 154781 8604 79580929
Epidermal necrosis 52.11 10.60 34 154821 1483 79588050
Impulsive behaviour 52.09 10.60 44 154811 2856 79586677
Hallucination 51.77 10.60 314 154541 85431 79504102
Hypertonia 51.74 10.60 67 154788 7165 79582368
Disorientation 51.51 10.60 250 154605 62526 79527007
Renal failure 51.48 10.60 208 154647 200760 79388773
Neoplasm progression 51.45 10.60 18 154837 51664 79537869
Tonic convulsion 51.21 10.60 39 154816 2181 79587352
Diverticulitis 51.18 10.60 13 154842 45923 79543610
Therapeutic response unexpected 51.09 10.60 117 154738 19829 79569704
Malaise 51.02 10.60 658 154197 489211 79100322
Pulmonary embolism 51.00 10.60 167 154688 171487 79418046
Skin degenerative disorder 50.85 10.60 12 154843 21 79589512
Fibromyalgia 50.76 10.60 31 154824 64309 79525224
Platelet count decreased 50.16 10.60 201 154654 194463 79395070
SJS-TEN overlap 50.10 10.60 26 154829 733 79588800
Heart rate decreased 49.97 10.60 38 154817 70278 79519255
Transaminases increased 49.83 10.60 216 154639 51527 79538006
Withdrawal syndrome 49.45 10.60 139 154716 26715 79562818
Staring 49.31 10.60 41 154814 2604 79586929
Abdominal pain upper 49.30 10.60 245 154610 223574 79365959
Gestational diabetes 49.30 10.60 61 154794 6232 79583301
Hypomagnesaemia 49.06 10.60 15 154840 46896 79542637
Drug withdrawal convulsions 49.02 10.60 38 154817 2182 79587351
Asthma 48.55 10.60 120 154735 134975 79454558
Tachycardia 48.29 10.60 543 154312 177225 79412308
Pulmonary fibrosis 48.17 10.60 13 154842 44099 79545434
Psychomotor skills impaired 48.01 10.60 55 154800 5182 79584351
Colitis 47.91 10.60 43 154812 73264 79516269
Unintended pregnancy 47.87 10.60 48 154807 3885 79585648
Upper gastrointestinal haemorrhage 47.50 10.60 11 154844 41369 79548164
Pulmonary hypertension 47.43 10.60 17 154838 48063 79541470
Enanthema 47.36 10.60 26 154829 823 79588710
Mouth ulceration 47.21 10.60 173 154682 38221 79551312
Product dispensing error 47.13 10.60 89 154766 13174 79576359
Melaena 47.12 10.60 30 154825 60860 79528673
Nausea 46.98 10.60 1459 153396 955737 78633796
Dysmetria 46.88 10.60 28 154827 1043 79588490
Cytokine release syndrome 46.81 10.60 7 154848 35991 79553542
Blood creatine phosphokinase increased 46.43 10.60 252 154603 65838 79523695
Mental status changes 46.15 10.60 254 154601 66705 79522828
Pregnancy with implant contraceptive 45.91 10.60 34 154821 1822 79587711
Accidental overdose 45.88 10.60 175 154680 39406 79550127
Developmental delay 45.77 10.60 29 154826 1202 79588331
Cellulitis 45.68 10.60 89 154766 108971 79480562
Illusion 45.57 10.60 33 154822 1708 79587825
Psychiatric symptom 45.45 10.60 62 154793 6973 79582560
Postictal state 45.38 10.60 34 154821 1855 79587678
Lip ulceration 45.35 10.60 37 154818 2288 79587245
Salivary hypersecretion 45.13 10.60 91 154764 14133 79575400
Posture abnormal 44.90 10.60 46 154809 3820 79585713
Chest discomfort 44.78 10.60 129 154726 137915 79451618
Drug abuse 44.67 10.60 498 154357 162193 79427340
Inappropriate affect 44.56 10.60 31 154824 1505 79588028
Caesarean section 44.40 10.60 84 154771 12451 79577082
Hip arthroplasty 44.16 10.60 8 154847 35748 79553785
Ischaemic stroke 44.11 10.60 6 154849 33125 79556408
Excessive eye blinking 43.97 10.60 32 154823 1669 79587864
Cerebral infarction 43.63 10.60 17 154838 45659 79543874
Drug resistance 43.59 10.60 180 154675 42033 79547500
Inappropriate antidiuretic hormone secretion 43.45 10.60 131 154724 26182 79563351
Simple partial seizures 43.29 10.60 23 154832 681 79588852
Psychogenic seizure 42.52 10.60 33 154822 1898 79587635
Off label use 42.52 10.60 1391 153464 905824 78683709
Lung neoplasm malignant 42.31 10.60 3 154852 27789 79561744
Thrombosis 42.27 10.60 61 154794 84039 79505494
Oculomucocutaneous syndrome 42.21 10.60 18 154837 321 79589212
Suicide threat 42.07 10.60 12 154843 57 79589476
Nasal congestion 42.07 10.60 52 154803 76500 79513033
Affect lability 41.82 10.60 77 154778 11182 79578351
Irregular sleep phase 41.72 10.60 13 154842 88 79589445
Abdominal distension 41.66 10.60 108 154747 119542 79469991
Live birth 41.60 10.60 104 154751 18640 79570893
Dysmorphism 41.53 10.60 21 154834 560 79588973
Hostility 41.39 10.60 35 154820 2275 79587258
Influenza 41.39 10.60 122 154733 129484 79460049
Gambling disorder 41.12 10.60 33 154822 1993 79587540
Eosinophilic myocarditis 41.03 10.60 27 154828 1195 79588338
Increased appetite 40.86 10.60 79 154776 11899 79577634
Haematuria 40.81 10.60 44 154811 68792 79520741
Pharyngeal erythema 40.78 10.60 33 154822 2017 79587516
Persecutory delusion 40.76 10.60 49 154806 4860 79584673
Skin exfoliation 40.68 10.60 213 154642 54887 79534646
Product use issue 40.51 10.60 240 154615 209582 79379951
Metastases to liver 40.51 10.60 4 154851 28310 79561223
Obsessive thoughts 40.43 10.60 26 154829 1106 79588427
Weight decreased 40.39 10.60 468 154387 354730 79234803
Tachyphrenia 40.36 10.60 33 154822 2047 79587486
Injection site erythema 40.02 10.60 56 154799 78141 79511392
Blood creatinine increased 40.00 10.60 160 154695 154897 79434636
Knee arthroplasty 39.84 10.60 17 154838 43231 79546302
Osteonecrosis of jaw 39.81 10.60 17 154838 43209 79546324
Vision blurred 39.73 10.60 346 154509 105552 79483981
Pulmonary oedema 39.64 10.60 69 154786 88185 79501348
Pain in jaw 39.64 10.60 20 154835 46131 79543402
Feelings of worthlessness 39.60 10.60 20 154835 532 79589001
Therapeutic response changed 39.49 10.60 27 154828 1274 79588259
Pregnancy on oral contraceptive 39.37 10.60 23 154832 822 79588711
Angina pectoris 39.33 10.60 26 154829 51706 79537827
Distractibility 39.33 10.60 22 154833 723 79588810
Intellectual disability 39.14 10.60 27 154828 1293 79588240
Osteoporosis 38.76 10.60 29 154826 54083 79535450
Educational problem 38.76 10.60 18 154837 396 79589137
Persistent genital arousal disorder 38.60 10.60 16 154839 265 79589268
Constipation 38.28 10.60 358 154497 282692 79306841
Retinogram abnormal 38.27 10.60 17 154838 336 79589197
Intermenstrual bleeding 38.23 10.60 52 154803 5832 79583701
Tonic clonic movements 37.92 10.60 33 154822 2231 79587302
Oedema 37.87 10.60 113 154742 119467 79470066
Mucosal inflammation 37.81 10.60 55 154800 75525 79514008
Change in seizure presentation 37.70 10.60 19 154836 503 79589030
Wrong schedule 37.55 10.60 17 154838 352 79589181
Septic shock 37.50 10.60 118 154737 122683 79466850
Injection site pain 37.41 10.60 128 154727 129710 79459823
Drug titration error 37.39 10.60 25 154830 1137 79588396
Cytomegalovirus infection 37.35 10.60 18 154837 42626 79546907
Libido increased 37.27 10.60 31 154824 1970 79587563
Paradoxical drug reaction 37.18 10.60 57 154798 7128 79582405
Migraine 37.17 10.60 294 154561 87199 79502334
Haemorrhoids 37.11 10.60 6 154849 29122 79560411
Blood cholesterol increased 37.11 10.60 66 154789 83654 79505879
Aphasia 36.84 10.60 184 154671 46548 79542985
Pseudolymphoma 36.56 10.60 25 154830 1180 79588353
Bursitis 36.52 10.60 12 154843 35832 79553701
Cataract 36.50 10.60 40 154815 62080 79527453
Lactic acidosis 36.39 10.60 50 154805 70309 79519224
Coordination abnormal 36.28 10.60 94 154761 17218 79572315
Joint range of motion decreased 35.98 10.60 10 154845 33272 79556261
Prostate cancer 35.96 10.60 10 154845 33258 79556275
Learning disability 35.91 10.60 14 154841 196 79589337
Drug clearance increased 35.83 10.60 15 154840 255 79589278
Pulmonary arterial hypertension 35.79 10.60 6 154849 28360 79561173
Gait disturbance 35.77 10.60 584 154271 206922 79382611
Multiple congenital abnormalities 35.63 10.60 12 154843 107 79589426
Photophobia 35.61 10.60 104 154751 20424 79569109
Product administration error 35.44 10.60 139 154716 31707 79557826
Hepatocellular injury 35.15 10.60 184 154671 47409 79542124
Stomatitis 35.04 10.60 156 154699 146601 79442932
Cerebellar atrophy 35.02 10.60 24 154831 1137 79588396
Hepatotoxicity 34.92 10.60 29 154826 51323 79538210
Lymphangioleiomyomatosis 34.86 10.60 13 154842 160 79589373
Dissociation 34.81 10.60 41 154814 3980 79585553
Placental disorder 34.74 10.60 22 154833 911 79588622
Pneumocystis jirovecii pneumonia 34.71 10.60 10 154845 32498 79557035
Traumatic coma 34.64 10.60 10 154845 50 79589483
Benzodiazepine drug level increased 34.33 10.60 14 154841 222 79589311
Angiofibroma 34.06 10.60 12 154843 124 79589409
Ureteric perforation 33.90 10.60 8 154847 14 79589519
Lethargy 33.90 10.60 272 154583 81020 79508513
Myelosuppression 33.81 10.60 18 154837 40278 79549255
Derealisation 33.77 10.60 27 154828 1622 79587911
Cerebral atrophy 33.55 10.60 58 154797 8017 79581516
Epistaxis 33.45 10.60 108 154747 111407 79478126
Rash vesicular 33.38 10.60 49 154806 5896 79583637
Mucosal erosion 33.32 10.60 31 154824 2287 79587246
Seizure cluster 33.11 10.60 16 154839 386 79589147
Skin erosion 33.09 10.60 42 154813 4403 79585130
Psychotic symptom 32.98 10.60 33 154822 2664 79586869
Oral mucosal blistering 32.92 10.60 50 154805 6201 79583332
Autism spectrum disorder 32.84 10.60 23 154832 1129 79588404
Negative symptoms in schizophrenia 32.76 10.60 12 154843 140 79589393
Human herpesvirus 6 infection 32.70 10.60 46 154809 5324 79584209
Erythema of eyelid 32.45 10.60 32 154823 2538 79586995
Palmar-plantar erythrodysaesthesia syndrome 32.20 10.60 12 154843 33122 79556411
Urinary incontinence 32.19 10.60 161 154694 40748 79548785
Personality disorder 32.15 10.60 49 154806 6097 79583436
Oxygen saturation decreased 32.13 10.60 135 154720 128912 79460621
Premature labour 31.94 10.60 58 154797 8332 79581201
Persistent depressive disorder 31.90 10.60 23 154832 1182 79588351
Hepatic cirrhosis 31.71 10.60 14 154841 34892 79554641
Hypoxia 31.66 10.60 99 154756 103144 79486389
Delirium 31.48 10.60 276 154579 84351 79505182
Granulocytopenia 31.46 10.60 69 154786 11362 79578171
Urinary tract infection 31.46 10.60 361 154494 274151 79315382
Product quality issue 31.40 10.60 140 154715 33800 79555733
Hypotonia 31.33 10.60 74 154781 12796 79576737
Peritonitis 31.11 10.60 8 154847 28028 79561505
Feeling drunk 31.11 10.60 42 154813 4677 79584856
Dysphoria 31.00 10.60 42 154813 4692 79584841
Blood pressure diastolic decreased 30.99 10.60 10 154845 30206 79559327
Erythema 30.89 10.60 607 154248 222683 79366850
Rapid eye movement sleep behaviour disorder 30.87 10.60 16 154839 450 79589083
Decreased interest 30.85 10.60 37 154818 3660 79585873
Flat affect 30.71 10.60 28 154827 2013 79587520
Injury corneal 30.64 10.60 10 154845 80 79589453
Drooling 30.60 10.60 47 154808 5887 79583646
Bone pain 30.48 10.60 38 154817 55704 79533829
Musculoskeletal stiffness 30.28 10.60 207 154648 174801 79414732
Gastric ulcer 30.17 10.60 14 154841 33891 79555642
Neoplasm malignant 30.12 10.60 12 154843 31798 79557735
Chapped lips 30.00 10.60 30 154825 2420 79587113
Red blood cell sedimentation rate increased 29.96 10.60 27 154828 45915 79543618
Hyperprolactinaemia 29.89 10.60 41 154814 4635 79584898
Red blood cell sedimentation rate abnormal 29.89 10.60 3 154852 20960 79568573
Gout 29.58 10.60 6 154849 24743 79564790
Skin ulcer 29.52 10.60 37 154818 54113 79535420
Symblepharon 29.50 10.60 12 154843 189 79589344
Basal cell carcinoma 29.49 10.60 18 154837 37357 79552176
Device related infection 29.25 10.60 15 154840 34279 79555254
Full blood count decreased 29.10 10.60 8 154847 26811 79562722
Genital erosion 29.00 10.60 15 154840 420 79589113
Bundle branch block right 28.82 10.60 66 154789 11185 79578348
Pneumonitis 28.80 10.60 46 154809 60814 79528719
Polyhydramnios 28.66 10.60 25 154830 1695 79587838
Femur fracture 28.62 10.60 20 154835 38632 79550901
Suspiciousness 28.54 10.60 17 154838 630 79588903
Treatment failure 28.34 10.60 204 154651 170282 79419251
Hypercalcaemia 28.30 10.60 20 154835 38410 79551123
Adrenal insufficiency 28.22 10.60 10 154845 28477 79561056
Cerebellar ataxia 28.21 10.60 26 154829 1895 79587638
Transfusion 28.08 10.60 4 154851 21326 79568207
Vanishing bile duct syndrome 27.95 10.60 25 154830 1753 79587780
Right ventricular failure 27.46 10.60 6 154849 23491 79566042
Lichen spinulosus 27.33 10.60 6 154849 6 79589527
Hepatic enzyme increased 27.31 10.60 225 154630 182385 79407148
Wrong patient received product 27.30 10.60 39 154816 4579 79584954
Hyperglycaemia 27.25 10.60 60 154795 70275 79519258
Premature baby 27.01 10.60 35 154820 3745 79585788
Microcephaly 26.94 10.60 11 154844 175 79589358
Respiratory acidosis 26.83 10.60 64 154791 11136 79578397
Chronic kidney disease 26.82 10.60 55 154800 66099 79523434
Oesophagitis 26.82 10.60 7 154848 24282 79565251
Cystitis 26.74 10.60 38 154817 52694 79536839
Blood pressure diastolic abnormal 26.73 10.60 3 154852 19199 79570334
False positive investigation result 26.68 10.60 20 154835 1092 79588441
Automatism 26.66 10.60 11 154844 180 79589353
Transferrin increased 26.58 10.60 7 154848 23 79589510
Neonatal infection 26.58 10.60 7 154848 23 79589510
Oral mucosal eruption 26.42 10.60 17 154838 724 79588809
Intention tremor 26.31 10.60 17 154838 729 79588804
Contusion 26.22 10.60 175 154680 148601 79440932
Haemorrhage 26.13 10.60 90 154765 91028 79498505
Angiomyolipoma 26.06 10.60 11 154844 191 79589342
Syncope 25.98 10.60 223 154632 179226 79410307
Scab 25.96 10.60 61 154794 10511 79579022
Bezoar 25.95 10.60 29 154826 2659 79586874
Maternal exposure before pregnancy 25.95 10.60 37 154818 4336 79585197
Pulmonary mass 25.82 10.60 12 154843 29022 79560511
Localised infection 25.82 10.60 21 154834 37554 79551979
Skin lesion 25.73 10.60 154 154701 41690 79547843
Clostridium difficile infection 25.62 10.60 27 154828 42658 79546875
Self-medication 25.56 10.60 40 154815 5092 79584441
Parasomnia 25.43 10.60 15 154840 546 79588987
Loss of personal independence in daily activities 25.11 10.60 108 154747 102472 79487061
Drug level changed 25.08 10.60 15 154840 560 79588973
Lennox-Gastaut syndrome 25.06 10.60 11 154844 211 79589322
Postictal paralysis 25.03 10.60 13 154842 367 79589166
Delusional perception 25.03 10.60 13 154842 367 79589166
Chorea 24.94 10.60 27 154828 2390 79587143
Convulsive threshold lowered 24.90 10.60 18 154837 929 79588604
Metastases to lung 24.88 10.60 3 154852 18160 79571373
Galactorrhoea 24.88 10.60 33 154822 3613 79585920
Purpura 24.86 10.60 89 154766 19438 79570095
Clostridium difficile colitis 24.85 10.60 16 154839 32267 79557266
Normal newborn 24.56 10.60 47 154808 7025 79582508
Injection site bruising 24.53 10.60 26 154829 40976 79548557
Hypervolaemia 24.52 10.60 28 154827 42662 79546871
Hepatosplenomegaly 24.45 10.60 43 154812 6026 79583507
Therapeutic product effective for unapproved indication 24.42 10.60 9 154846 107 79589426
Osteomyelitis 24.34 10.60 17 154838 32848 79556685
Bacteraemia 24.28 10.60 17 154838 32807 79556726
Hypothermia 24.28 10.60 98 154757 22648 79566885
Hypersomnia 24.27 10.60 99 154756 22987 79566546
Hyperexplexia 24.25 10.60 7 154848 35 79589498
Tongue biting 24.20 10.60 25 154830 2096 79587437
Cerebral haemorrhage 24.20 10.60 47 154808 57626 79531907
Lymphadenitis 24.19 10.60 37 154818 4618 79584915
Respiratory depression 24.09 10.60 112 154743 27518 79562015
Heart rate irregular 24.07 10.60 17 154838 32662 79556871
Hyperammonaemia 24.04 10.60 61 154794 11032 79578501
Soft tissue injury 24.04 10.60 23 154832 1758 79587775
Apnoea 23.96 10.60 63 154792 11641 79577892
Dermatitis exfoliative 23.94 10.60 60 154795 10769 79578764
Sternal fracture 23.92 10.60 27 154828 2503 79587030
Brain death 23.88 10.60 41 154814 5636 79583897
Bronchiectasis 23.69 10.60 7 154848 22379 79567154
Hypokalaemia 23.63 10.60 173 154682 143867 79445666
Developmental regression 23.62 10.60 7 154848 39 79589494
Sinus congestion 23.42 10.60 5 154850 19891 79569642
Eyelid oedema 23.41 10.60 69 154786 13618 79575915
Hiatus hernia 23.41 10.60 8 154847 23304 79566229
Disseminated intravascular coagulation 23.39 10.60 134 154721 35708 79553825
Altered pitch perception 23.19 10.60 6 154849 18 79589515
Pregnancy on contraceptive 23.17 10.60 17 154838 898 79588635
Vulvar erosion 23.07 10.60 10 154845 186 79589347
Hypoglycaemia 23.05 10.60 110 154745 101484 79488049
Histiocytosis 23.04 10.60 7 154848 43 79589490
Blood glucose increased 22.99 10.60 130 154725 114845 79474688
Pulmonary congestion 22.89 10.60 12 154843 27088 79562445
Electrocardiogram ST segment depression 22.89 10.60 37 154818 4841 79584692
Schizophrenia 22.84 10.60 74 154781 15366 79574167
Pregnancy 22.79 10.60 108 154747 26743 79562790
Bladder cancer 22.79 10.60 5 154850 19521 79570012
Drug withdrawal syndrome 22.79 10.60 130 154725 34588 79554945
Essential tremor 22.75 10.60 21 154834 1534 79587999
Drug dose titration not performed 22.69 10.60 16 154839 794 79588739
Tonsillar hypertrophy 22.67 10.60 21 154834 1541 79587992
Attention deficit hyperactivity disorder 22.65 10.60 30 154825 3279 79586254
Inappropriate schedule of product administration 22.64 10.60 159 154696 133469 79456064
COVID-19 pneumonia 22.61 10.60 14 154841 28835 79560698
Hospitalisation 22.59 10.60 100 154755 94136 79495397
Atrial septal defect 22.56 10.60 23 154832 1899 79587634
Haematemesis 22.45 10.60 42 154813 52222 79537311
Nephropathy toxic 22.33 10.60 6 154849 20413 79569120
Dyspepsia 22.21 10.60 122 154733 108565 79480968
Sleep-related eating disorder 22.11 10.60 15 154840 699 79588834
Therapy non-responder 22.10 10.60 98 154757 92207 79497326
Cholestasis of pregnancy 21.93 10.60 17 154838 976 79588557
Viral rash 21.91 10.60 12 154843 378 79589155
Brain malformation 21.90 10.60 7 154848 52 79589481
Cardiovascular symptom 21.90 10.60 7 154848 52 79589481
Lip scab 21.87 10.60 5 154850 7 79589526
Snoring 21.86 10.60 39 154816 5527 79584006
Vomiting projectile 21.86 10.60 22 154833 1789 79587744
Pregnancy with contraceptive device 21.81 10.60 31 154824 3623 79585910
Bronchopulmonary aspergillosis 21.79 10.60 8 154847 22286 79567247
Retinal deposits 21.77 10.60 9 154846 148 79589385
Dermatitis bullous 21.74 10.60 69 154786 14176 79575357
Tongue eruption 21.71 10.60 8 154847 95 79589438
Acute coronary syndrome 21.66 10.60 7 154848 21126 79568407
Homicidal ideation 21.63 10.60 30 154825 3427 79586106
Delivery 21.58 10.60 15 154840 727 79588806
Inflammation 21.57 10.60 101 154754 93652 79495881
Idiopathic generalised epilepsy 21.45 10.60 7 154848 56 79589477
Maternal drugs affecting foetus 21.34 10.60 21 154834 1662 79587871
Impatience 21.31 10.60 14 154841 618 79588915
Plagiocephaly 21.30 10.60 6 154849 27 79589506
Fungal infection 21.26 10.60 30 154825 41718 79547815
Nightmare 21.22 10.60 103 154752 25758 79563775
Resting tremor 21.21 10.60 20 154835 1501 79588032
Ventricular septal defect 21.21 10.60 13 154842 508 79589025
Sleep paralysis 21.19 10.60 14 154841 624 79588909
Joint stiffness 21.13 10.60 29 154826 40801 79548732
Grip strength decreased 21.12 10.60 8 154847 21861 79567672
Differential white blood cell count abnormal 21.08 10.60 23 154832 2054 79587479
Restless legs syndrome 21.00 10.60 86 154769 20006 79569527
Visual field defect 20.93 10.60 51 154804 8994 79580539
Post-traumatic neck syndrome 20.92 10.60 23 154832 2071 79587462
Cardiac disorder 20.91 10.60 62 154793 65695 79523838
Lymphocytic infiltration 20.85 10.60 20 154835 1533 79588000
Colitis ulcerative 20.82 10.60 22 154833 34720 79554813
Conjunctival abrasion 20.76 10.60 5 154850 10 79589523
Lip oedema 20.75 10.60 41 154814 6275 79583258
Stupor 20.66 10.60 43 154812 6829 79582704
Blood potassium increased 20.57 10.60 16 154839 29259 79560274
Nephrogenic diabetes insipidus 20.56 10.60 23 154832 2111 79587422
Macule 20.54 10.60 27 154828 2930 79586603
Lymphocyte morphology abnormal 20.29 10.60 16 154839 942 79588591
Haematotoxicity 20.22 10.60 3 154852 15516 79574017
Myalgia 20.15 10.60 247 154608 185394 79404139
Epidermolysis 20.14 10.60 16 154839 952 79588581
Torticollis 20.10 10.60 24 154831 2363 79587170
Acute psychosis 20.02 10.60 32 154823 4148 79585385
Shock haemorrhagic 19.94 10.60 7 154848 20053 79569480
Placental infarction 19.90 10.60 8 154847 122 79589411
White blood cell count decreased 19.88 10.60 252 154603 188036 79401497
Pectus excavatum 19.85 10.60 5 154850 13 79589520
Somnambulism 19.84 10.60 38 154817 5683 79583850
Wound infection 19.71 10.60 11 154844 23980 79565553
Nodule 19.69 10.60 10 154845 22984 79566549
Self esteem decreased 19.66 10.60 16 154839 986 79588547
Exomphalos 19.64 10.60 7 154848 75 79589458
Eye discharge 19.62 10.60 39 154816 5995 79583538
Mitral valve incompetence 19.58 10.60 16 154839 28549 79560984
Bradypnoea 19.54 10.60 39 154816 6013 79583520
Ejection fraction decreased 19.51 10.60 23 154832 34554 79554979
Drug screen positive 19.49 10.60 39 154816 6024 79583509
Mucosal ulceration 19.46 10.60 21 154834 1852 79587681
Economic problem 19.41 10.60 23 154832 2247 79587286
Echolalia 19.40 10.60 11 154844 371 79589162
Tricuspid valve incompetence 19.39 10.60 7 154848 19705 79569828
Palpitations 19.38 10.60 155 154700 126455 79463078
Throat irritation 19.32 10.60 31 154824 40915 79548618
Concussion 19.30 10.60 51 154804 9452 79580081
Gamma-glutamyltransferase increased 19.14 10.60 176 154679 54504 79535029
Lipids 19.09 10.60 5 154850 16 79589517
Lower gastrointestinal haemorrhage 19.08 10.60 4 154851 16121 79573412
Drop attacks 18.94 10.60 16 154839 1039 79588494
Terminal insomnia 18.91 10.60 17 154838 1200 79588333
Bile acid malabsorption 18.90 10.60 9 154846 210 79589323
Panic attack 18.84 10.60 95 154760 24121 79565412
Presyncope 18.52 10.60 32 154823 41022 79548511
Colon cancer 18.48 10.60 3 154852 14520 79575013
Hypotension 18.47 10.60 684 154171 439633 79149900
Miosis 18.45 10.60 70 154785 15719 79573814
Vagal nerve stimulator implantation 18.42 10.60 5 154850 19 79589514
Anticonvulsant drug level therapeutic 18.42 10.60 5 154850 19 79589514
Stereotypy 18.35 10.60 15 154840 930 79588603
Cerebral disorder 18.25 10.60 36 154819 5502 79584031
Anaphylactic shock 18.19 10.60 26 154829 35970 79553563
Cardiac failure acute 18.15 10.60 7 154848 18922 79570611
Blood calcium decreased 18.13 10.60 21 154834 31798 79557735
Compulsive shopping 18.09 10.60 14 154841 802 79588731
Tendonitis 18.08 10.60 12 154843 23818 79565715
Retinal pigmentation 18.02 10.60 7 154848 97 79589436
Dyslexia 18.01 10.60 9 154846 234 79589299
Transient ischaemic attack 18.00 10.60 48 154807 52647 79536886
Burnout syndrome 17.95 10.60 10 154845 326 79589207
Judgement impaired 17.95 10.60 17 154838 1283 79588250
Lymphocyte stimulation test positive 17.95 10.60 16 154839 1117 79588416
Central nervous system lesion 17.94 10.60 62 154793 13306 79576227
Wrong product administered 17.93 10.60 48 154807 8964 79580569
Premature rupture of membranes 17.93 10.60 30 154825 4039 79585494
Leukocytosis 17.89 10.60 145 154710 43310 79546223
Conjunctival disorder 17.81 10.60 10 154845 331 79589202
Coprolalia 17.77 10.60 6 154849 54 79589479
Gestational hypertension 17.68 10.60 20 154835 1859 79587674
Regressive behaviour 17.52 10.60 8 154847 169 79589364
Strabismus 17.48 10.60 23 154832 2498 79587035
Flight of ideas 17.41 10.60 14 154841 848 79588685
Disorganised speech 17.36 10.60 21 154834 2096 79587437
Insomnia 17.34 10.60 610 154245 244560 79344973
Respiratory failure 17.33 10.60 247 154608 180664 79408869
Gastric haemorrhage 17.27 10.60 4 154851 15046 79574487
Incorrect dose administered 17.27 10.60 226 154629 76404 79513129
Blister 17.26 10.60 327 154528 119149 79470384
Limbic encephalitis 17.23 10.60 14 154841 861 79588672
Pyramidal tract syndrome 17.21 10.60 12 154843 585 79588948
Coma scale 17.21 10.60 6 154849 60 79589473
Hallucinations, mixed 17.15 10.60 40 154815 6859 79582674
Bone marrow failure 17.12 10.60 47 154808 51060 79538473
Dysphonia 17.11 10.60 55 154800 56817 79532716
Gait deviation 17.03 10.60 6 154849 62 79589471
Blood urea increased 17.01 10.60 44 154811 48746 79540787
Emotional disorder 16.99 10.60 64 154791 14323 79575210
Rhabdomyolysis 16.92 10.60 288 154567 102843 79486690
Flatulence 16.92 10.60 36 154819 42688 79546845
Rhinorrhoea 16.89 10.60 83 154772 75991 79513542
Conjunctival erosion 16.86 10.60 8 154847 185 79589348
Hereditary ataxia 16.85 10.60 5 154850 28 79589505
Amnesia 16.83 10.60 192 154663 62865 79526668
Chills 16.71 10.60 215 154640 160019 79429514
Herpangina 16.70 10.60 5 154850 29 79589504
Spinal osteoarthritis 16.67 10.60 6 154849 16921 79572612
Congenital anomaly 16.66 10.60 10 154845 376 79589157
Spinal stenosis 16.60 10.60 5 154850 15786 79573747
Anorgasmia 16.56 10.60 16 154839 1238 79588295
Type IV hypersensitivity reaction 16.55 10.60 29 154826 4052 79585481
Odynophagia 16.50 10.60 54 154801 11273 79578260
Immunodeficiency 16.47 10.60 11 154844 21757 79567776
Injection site pruritus 16.43 10.60 36 154819 42247 79547286
Blood pressure diastolic increased 16.42 10.60 4 154851 14538 79574995
Dry skin 16.39 10.60 72 154783 67923 79521610
Head titubation 16.37 10.60 14 154841 924 79588609
Hyperhomocysteinaemia 16.34 10.60 11 154844 506 79589027
Squamous cell carcinoma 16.32 10.60 5 154850 15617 79573916
Oscillopsia 16.29 10.60 8 154847 200 79589333
Congenital renal disorder 16.29 10.60 4 154851 9 79589524
Selective IgA immunodeficiency 16.29 10.60 4 154851 9 79589524
Cleft lip 16.29 10.60 4 154851 9 79589524
Heavy menstrual bleeding 16.28 10.60 62 154793 13949 79575584
Autoscopy 16.23 10.60 6 154849 72 79589461
Brain oedema 16.19 10.60 94 154761 25169 79564364
Respiratory tract infection 16.15 10.60 45 154810 48644 79540889
Hyperkinesia 16.06 10.60 23 154832 2706 79586827
Blood magnesium decreased 16.01 10.60 6 154849 16506 79573027
Musculoskeletal disorder 16.01 10.60 11 154844 21437 79568096
Renal tubular necrosis 15.99 10.60 15 154840 25024 79564509
Sleep disorder due to a general medical condition 15.98 10.60 4 154851 14273 79575260
Movement disorder 15.92 10.60 99 154756 27160 79562373
Peripheral sensory neuropathy 15.91 10.60 3 154852 13030 79576503
Dissociative disorder 15.88 10.60 13 154842 808 79588725
Symptom recurrence 15.87 10.60 21 154834 2293 79587240
Illogical thinking 15.86 10.60 6 154849 77 79589456
Sciatica 15.82 10.60 25 154830 33197 79556336
International normalised ratio increased 15.76 10.60 98 154757 84623 79504910
Hyperphagia 15.75 10.60 22 154833 2530 79587003
Neonatal aspiration 15.74 10.60 3 154852 0 79589533
Congenital cardiovascular anomaly 15.74 10.60 3 154852 0 79589533
Laryngeal tremor 15.74 10.60 3 154852 0 79589533
Pulmonary toxicity 15.71 10.60 3 154852 12911 79576622
Musculoskeletal chest pain 15.62 10.60 15 154840 24749 79564784
Epidermolysis bullosa 15.60 10.60 8 154847 220 79589313
Ocular hyperaemia 15.58 10.60 101 154754 28105 79561428
Squamous cell carcinoma of skin 15.58 10.60 4 154851 14029 79575504
Orthostatic hypertension 15.55 10.60 13 154842 832 79588701
Opsoclonus myoclonus 15.47 10.60 8 154847 224 79589309
Disinhibition 15.44 10.60 22 154833 2576 79586957
Aspergillus infection 15.44 10.60 9 154846 19152 79570381
Oral mucosal erythema 15.43 10.60 19 154836 1931 79587602
Skin cancer 15.38 10.60 5 154850 15035 79574498
Bone disorder 15.37 10.60 9 154846 19104 79570429
Haematocrit decreased 15.34 10.60 64 154791 61248 79528285
Injection site swelling 15.31 10.60 44 154811 47088 79542445
Maternal exposure during pregnancy 15.27 10.60 360 154495 136178 79453355
Frequent bowel movements 15.26 10.60 21 154834 29518 79560015
Bipolar II disorder 15.23 10.60 10 154845 441 79589092
Morose 15.21 10.60 5 154850 41 79589492
Impulse-control disorder 15.21 10.60 18 154837 1756 79587777
Creatinine renal clearance decreased 15.20 10.60 9 154846 18993 79570540
Myelodysplastic syndrome 15.20 10.60 22 154833 30279 79559254
Joint effusion 15.18 10.60 8 154847 18006 79571527
Diverticulum 15.15 10.60 5 154850 14891 79574642
Hypophosphataemia 15.15 10.60 10 154845 19903 79569630
Vestibular migraine 15.12 10.60 7 154848 153 79589380
Spinal compression fracture 15.09 10.60 7 154848 16951 79572582
Peripheral venous disease 15.06 10.60 6 154849 15903 79573630
Head injury 15.01 10.60 124 154731 37245 79552288
Drug ineffective 14.99 10.60 2353 152502 1078560 78510973
Adverse event 14.98 10.60 63 154792 60151 79529382
Dysmetropsia 14.96 10.60 6 154849 91 79589442
Encephalocele 14.90 10.60 5 154850 44 79589489
Pancreatic carcinoma 14.82 10.60 4 154851 13573 79575960
Enuresis 14.78 10.60 24 154831 3152 79586381
Screaming 14.73 10.60 27 154828 3906 79585627
Blood test abnormal 14.73 10.60 8 154847 17702 79571831
Gastritis 14.73 10.60 46 154809 47947 79541586
Foot deformity 14.70 10.60 15 154840 24059 79565474
Myocarditis 14.68 10.60 82 154773 21651 79567882
Pancytopenia 14.60 10.60 230 154625 165515 79424018
Angular cheilitis 14.60 10.60 12 154843 750 79588783
Vulval disorder 14.57 10.60 11 154844 607 79588926
Pre-eclampsia 14.52 10.60 38 154817 7003 79582530
Immunodeficiency common variable 14.51 10.60 9 154846 359 79589174
Hallucination, olfactory 14.51 10.60 10 154845 478 79589055
Heart rate increased 14.51 10.60 157 154698 120567 79468966
Borderline personality disorder 14.50 10.60 13 154842 914 79588619
Antipsychotic drug level above therapeutic 14.46 10.60 19 154836 2061 79587472
Dysphemia 14.44 10.60 25 154830 3459 79586074
Limited symptom panic attack 14.43 10.60 5 154850 49 79589484
Social avoidant behaviour 14.33 10.60 30 154825 4784 79584749
Agranulocytosis 14.30 10.60 142 154713 44888 79544645
Substance abuse 14.28 10.60 49 154806 10477 79579056
Bruxism 14.28 10.60 27 154828 3999 79585534
Accidental death 14.27 10.60 28 154827 4263 79585270
Tooth disorder 14.22 10.60 18 154837 26215 79563318
Injection site haemorrhage 14.22 10.60 20 154835 27850 79561683
Metastases to central nervous system 14.21 10.60 7 154848 16368 79573165
Coronary artery occlusion 14.14 10.60 6 154849 15309 79574224
Feeling of despair 14.07 10.60 22 154833 2799 79586734
Blood pressure systolic abnormal 14.04 10.60 8 154847 17239 79572294
White blood cell count increased 13.96 10.60 213 154642 74420 79515113
Unevaluable event 13.92 10.60 58 154797 55527 79534006
Attention-seeking behaviour 13.92 10.60 6 154849 110 79589423
Exposure via transplant 13.86 10.60 4 154851 20 79589513
Conjunctival oedema 13.85 10.60 14 154841 1144 79588389
Drug tolerance decreased 13.84 10.60 4 154851 12974 79576559
Hyperuricaemia 13.81 10.60 3 154852 11796 79577737
Cholelithiasis 13.79 10.60 54 154801 52610 79536923
Upper respiratory tract infection 13.77 10.60 112 154743 91056 79498477
Lymph node pain 13.74 10.60 16 154839 1534 79587999
Full blood count abnormal 13.73 10.60 37 154818 40437 79549096
Antidepressant drug level above therapeutic 13.70 10.60 11 154844 665 79588868
Injection site rash 13.68 10.60 9 154846 17945 79571588
Acute encephalitis with refractory, repetitive partial seizures 13.67 10.60 3 154852 3 79589530
Pharyngeal exudate 13.67 10.60 3 154852 3 79589530
Mononucleosis heterophile test positive 13.67 10.60 3 154852 3 79589530
Rash pruritic 13.62 10.60 205 154650 71424 79518109
Alopecia universalis 13.59 10.60 8 154847 290 79589243
Renal injury 13.57 10.60 8 154847 16919 79572614
Acute myopia 13.53 10.60 6 154849 118 79589415
Anaphylactic reaction 13.53 10.60 101 154754 83642 79505891
Lip haemorrhage 13.49 10.60 14 154841 1180 79588353
Enthesopathy 13.49 10.60 3 154852 11605 79577928
Drug withdrawal syndrome neonatal 13.47 10.60 8 154847 295 79589238
Large intestine polyp 13.40 10.60 4 154851 12704 79576829
Cardiac murmur 13.38 10.60 7 154848 15817 79573716
Acquired immunodeficiency syndrome 13.37 10.60 8 154847 299 79589234
Pigmentation disorder 13.35 10.60 32 154823 5586 79583947
Blood pressure decreased 13.34 10.60 126 154729 99340 79490193
Carpal tunnel syndrome 13.31 10.60 11 154844 19517 79570016
Skin disorder 13.30 10.60 112 154743 33831 79555702
Muscle spasms 13.28 10.60 249 154606 174481 79415052
Cytopenia 13.26 10.60 12 154843 20371 79569162
Verbigeration 13.25 10.60 4 154851 24 79589509
Physical assault 13.24 10.60 16 154839 1595 79587938
Hypocalcaemia 13.20 10.60 51 154804 49873 79539660
Eclampsia 13.12 10.60 7 154848 209 79589324
Psoriasis 13.10 10.60 111 154744 89476 79500057
Conjunctival scar 13.09 10.60 7 154848 210 79589323
Drug level above therapeutic 13.08 10.60 42 154813 8681 79580852
Conjunctival irritation 13.00 10.60 6 154849 130 79589403
Agoraphobia 12.99 10.60 10 154845 568 79588965
Large intestine perforation 12.99 10.60 6 154849 14561 79574972
Tongue movement disturbance 12.97 10.60 9 154846 435 79589098
Conversion disorder 12.94 10.60 17 154838 1844 79587689
Protrusion tongue 12.92 10.60 9 154846 438 79589095
Sleep disorder 12.89 10.60 236 154619 85441 79504092
Blood loss anaemia 12.89 10.60 7 154848 15491 79574042
Ill-defined disorder 12.89 10.60 75 154780 65800 79523733
Drug-induced liver injury 12.87 10.60 190 154665 65927 79523606
Abnormal dreams 12.85 10.60 50 154805 11362 79578171
Pneumothorax 12.85 10.60 22 154833 28301 79561232
Hypersensitivity vasculitis 12.84 10.60 36 154819 6907 79582626
Blood iron decreased 12.79 10.60 7 154848 15427 79574106
Hyperventilation 12.73 10.60 39 154816 7860 79581673
Spinal pain 12.73 10.60 7 154848 15385 79574148
Hot flush 12.69 10.60 59 154796 54818 79534715
Bacterial infection 12.68 10.60 26 154829 31254 79558279
Pneumonia mycoplasmal 12.68 10.60 15 154840 1463 79588070
Night sweats 12.65 10.60 55 154800 52040 79537493
Orthostatic hypotension 12.63 10.60 61 154794 56103 79533430
Neutrophil count decreased 12.61 10.60 119 154736 93840 79495693
Hypospadias 12.60 10.60 6 154849 140 79589393
Intentional product misuse 12.58 10.60 257 154598 94908 79494625
Hallucination, tactile 12.53 10.60 10 154845 599 79588934
Spinal fracture 12.52 10.60 10 154845 18044 79571489
Motor developmental delay 12.51 10.60 7 154848 230 79589303
Photosensitivity reaction 12.51 10.60 77 154778 21050 79568483
Middle insomnia 12.47 10.60 63 154792 16006 79573527
Renal disorder 12.47 10.60 41 154814 42064 79547469
Wound healing normal 12.45 10.60 3 154852 6 79589527
Congenital renal cyst 12.45 10.60 3 154852 6 79589527
Gastroenteritis 12.45 10.60 30 154825 34052 79555481
Nervousness 12.43 10.60 109 154746 33306 79556227
Self-injurious ideation 12.42 10.60 24 154831 3614 79585919
Spina bifida 12.41 10.60 6 154849 145 79589388
Eye movement disorder 12.40 10.60 39 154816 7972 79581561
Lipids abnormal 12.36 10.60 10 154845 611 79588922
Febrile convulsion 12.36 10.60 12 154843 934 79588599
Rotator cuff syndrome 12.27 10.60 6 154849 14089 79575444
Paralogism 12.26 10.60 4 154851 32 79589501
Post procedural complication 12.25 10.60 17 154838 23812 79565721
Lip disorder 12.23 10.60 15 154840 1519 79588014
Sexually transmitted disease 12.22 10.60 6 154849 150 79589383
Gastritis erosive 12.22 10.60 3 154852 10844 79578689
Conjunctival ulcer 12.16 10.60 5 154850 81 79589452
Tooth malformation 12.15 10.60 6 154849 152 79589381
Teratogenicity 12.14 10.60 7 154848 244 79589289
Acute hepatic failure 12.14 10.60 100 154755 30013 79559520
Postoperative wound infection 12.09 10.60 5 154850 12956 79576577
Acute respiratory failure 12.07 10.60 67 154788 59474 79530059
Lymphocyte count decreased 12.06 10.60 49 154806 47240 79542293
Neglect of personal appearance 12.04 10.60 6 154849 155 79589378
Anorexia nervosa 12.01 10.60 7 154848 249 79589284
Failure to thrive 12.00 10.60 4 154851 11840 79577693
Drug ineffective for unapproved indication 11.92 10.60 152 154703 51086 79538447
Congestive cardiomyopathy 11.90 10.60 4 154851 11776 79577757
Oral herpes 11.84 10.60 22 154833 27432 79562101
Diabetes mellitus inadequate control 11.80 10.60 18 154837 24246 79565287
Upper-airway cough syndrome 11.76 10.60 4 154851 11689 79577844
Illiteracy 11.75 10.60 4 154851 37 79589496
Type 2 diabetes mellitus 11.73 10.60 64 154791 57058 79532475
Weight fluctuation 11.73 10.60 4 154851 11671 79577862
Ideas of reference 11.73 10.60 6 154849 164 79589369
Pathological fracture 11.70 10.60 3 154852 10534 79578999
Sputum discoloured 11.70 10.60 15 154840 21728 79567805
Negative thoughts 11.67 10.60 14 154841 1385 79588148
Bankruptcy 11.65 10.60 4 154851 38 79589495
Neurosurgery 11.63 10.60 5 154850 91 79589442
Subacute cutaneous lupus erythematosus 11.56 10.60 23 154832 3538 79585995
Neuropsychiatric symptoms 11.54 10.60 14 154841 1401 79588132
Arteriosclerosis 11.54 10.60 11 154844 18216 79571317
Genital lesion 11.52 10.60 9 154846 523 79589010
Altered visual depth perception 11.49 10.60 8 154847 389 79589144
Niemann-Pick disease 11.47 10.60 4 154851 40 79589493
Grimacing 11.43 10.60 10 154845 681 79588852
Gastric disorder 11.40 10.60 36 154819 37397 79552136
Breast cancer female 11.39 10.60 4 154851 11457 79578076
Visuospatial deficit 11.38 10.60 4 154851 41 79589492
Product name confusion 11.38 10.60 6 154849 175 79589358
Maculopathy 11.36 10.60 20 154835 2805 79586728
Antipsychotic drug level below therapeutic 11.35 10.60 13 154842 1225 79588308
Emphysema 11.34 10.60 9 154846 16291 79573242
Sexual dysfunction 11.30 10.60 37 154818 7726 79581807
Pica 11.30 10.60 4 154851 42 79589491
Lymphoedema 11.24 10.60 5 154850 12408 79577125
Epstein-Barr virus infection reactivation 11.22 10.60 16 154839 1876 79587657
Tooth infection 11.20 10.60 12 154843 18820 79570713
Body temperature decreased 11.19 10.60 29 154826 32116 79557417
Foaming at mouth 11.18 10.60 16 154839 1881 79587652
Anembryonic gestation 11.15 10.60 8 154847 408 79589125
Congenital umbilical hernia 11.14 10.60 3 154852 11 79589522
Clumsiness 11.13 10.60 21 154834 3106 79586427
Jaundice cholestatic 11.11 10.60 4 154851 11280 79578253
Thymus disorder 11.05 10.60 7 154848 290 79589243
Bundle branch block left 11.03 10.60 48 154807 11465 79578068
Tonsillar haemorrhage 11.03 10.60 7 154848 291 79589242
Stillbirth 11.03 10.60 24 154831 3931 79585602
Hypercapnic coma 11.01 10.60 8 154847 416 79589117
Pneumonia fungal 10.99 10.60 4 154851 11206 79578327
Ulcerative keratitis 10.99 10.60 23 154832 3666 79585867
Gambling 10.99 10.60 7 154848 293 79589240
Renal cancer 10.95 10.60 5 154850 12221 79577312
Breath sounds abnormal 10.90 10.60 9 154846 15975 79573558
Medication overuse headache 10.86 10.60 11 154844 901 79588632
Acquired epidermolysis bullosa 10.85 10.60 5 154850 108 79589425
Tendon rupture 10.80 10.60 5 154850 12121 79577412
Left ventricular dysfunction 10.79 10.60 13 154842 19348 79570185
Therapeutic product ineffective for unapproved indication 10.79 10.60 6 154849 195 79589338
Patent ductus arteriosus 10.77 10.60 5 154850 110 79589423
Eosinophil percentage increased 10.76 10.60 14 154841 1504 79588029
Anal erosion 10.74 10.60 4 154851 49 79589484
Mucosal exfoliation 10.74 10.60 3 154852 13 79589520
Sweat gland disorder 10.73 10.60 6 154849 197 79589336
Language disorder 10.72 10.60 21 154834 3193 79586340
Hyperpyrexia 10.70 10.60 31 154824 6061 79583472
Thrombocytopenia 10.68 10.60 414 154441 264845 79324688
Glycosylated haemoglobin increased 10.67 10.60 13 154842 19247 79570286

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 35.48 20.06 29 2233 3899 83631
Somnolence 23.96 20.06 37 2225 327 87203
Dehydration 23.31 20.06 41 2221 408 87122
Infantile apnoea 21.08 20.06 42 2220 463 87067

Pharmacologic Action:

SourceCodeDescription
ATC N03AX09 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D011619 Psychotropic Drugs
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35477 antimanic drugs
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:60798 EAA receptor antagonists
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Lennox-Gastaut syndrome indication 230418006
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Pancytopenia contraindication 127034005 DOID:12450
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.3 Basic
pKa2 0.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 4.21 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER IC50 5 CHEMBL CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.77 CHEMBL CHEMBL
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER IC50 4.02 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 3.84 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel IC50 4.74 WOMBAT-PK
Sodium channel protein type X alpha subunit Ion channel IC50 4.60 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel IC50 4.46 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.51 CHEMBL

External reference:

IDSource
D00354 KEGG_DRUG
4020896 VANDF
C0064636 UMLSCUI
CHEBI:6367 CHEBI
CHEMBL741 ChEMBL_ID
DB00555 DRUGBANK_ID
D000077213 MESH_DESCRIPTOR_UI
3878 PUBCHEM_CID
2622 IUPHAR_LIGAND_ID
5638 INN_ID
U3H27498KS UNII
196502 RXNORM
1506 MMSL
4957 MMSL
69610 MMSL
d03809 MMSL
003988 NDDF
387562000 SNOMEDCT_US
96195007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1526 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1526 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1527 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1527 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1528 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1528 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1529 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1529 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9939 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9940 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9941 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9942 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections