Stem definition | Drug id | CAS RN |
---|---|---|
1523 | 6740-88-1 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 200 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.41 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.90 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 19 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.47 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 19, 1970 | FDA | PAR STERILE PRODUCTS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 596.75 | 24.78 | 205 | 11149 | 23428 | 63454240 |
Drug ineffective for unapproved indication | 172.40 | 24.78 | 95 | 11259 | 33968 | 63443700 |
Propofol infusion syndrome | 171.92 | 24.78 | 39 | 11315 | 944 | 63476724 |
Body tinea | 170.77 | 24.78 | 44 | 11310 | 1841 | 63475827 |
Inhibitory drug interaction | 148.32 | 24.78 | 43 | 11311 | 2806 | 63474862 |
Infection susceptibility increased | 143.57 | 24.78 | 44 | 11310 | 3477 | 63474191 |
Dilatation intrahepatic duct acquired | 140.66 | 24.78 | 31 | 11323 | 655 | 63477013 |
Multiple-drug resistance | 138.66 | 24.78 | 47 | 11307 | 5123 | 63472545 |
Bronchospasm | 133.21 | 24.78 | 64 | 11290 | 17216 | 63460452 |
Mitochondrial DNA mutation | 131.86 | 24.78 | 27 | 11327 | 395 | 63477273 |
Oesophageal spasm | 127.22 | 24.78 | 39 | 11315 | 3084 | 63474584 |
Oesophageal pain | 120.70 | 24.78 | 39 | 11315 | 3662 | 63474006 |
Hydronephrosis | 118.62 | 24.78 | 51 | 11303 | 10611 | 63467057 |
Glucose tolerance impaired | 116.62 | 24.78 | 44 | 11310 | 6533 | 63471135 |
Intra-abdominal pressure increased | 114.52 | 24.78 | 22 | 11332 | 227 | 63477441 |
Drug ineffective | 108.66 | 24.78 | 419 | 10935 | 1044346 | 62433322 |
Poor quality sleep | 104.69 | 24.78 | 57 | 11297 | 19878 | 63457790 |
Hypotension | 104.64 | 24.78 | 180 | 11174 | 272424 | 63205244 |
Drug abuse | 99.54 | 24.78 | 91 | 11263 | 72427 | 63405241 |
Anaphylactic reaction | 94.74 | 24.78 | 85 | 11269 | 66015 | 63411653 |
Respiratory depression | 94.33 | 24.78 | 47 | 11307 | 13668 | 63464000 |
Purpura | 93.33 | 24.78 | 44 | 11310 | 11341 | 63466327 |
Blood lactic acid increased | 92.56 | 24.78 | 38 | 11316 | 7048 | 63470620 |
Impaired quality of life | 91.17 | 24.78 | 46 | 11308 | 13737 | 63463931 |
Pneumatosis | 91.08 | 24.78 | 20 | 11334 | 415 | 63477253 |
Blood gases abnormal | 89.03 | 24.78 | 22 | 11332 | 775 | 63476893 |
Necrosis ischaemic | 87.36 | 24.78 | 22 | 11332 | 838 | 63476830 |
Biliary dilatation | 86.78 | 24.78 | 27 | 11327 | 2242 | 63475426 |
Status epilepticus | 84.01 | 24.78 | 45 | 11309 | 15188 | 63462480 |
Bone density decreased | 82.93 | 24.78 | 44 | 11310 | 14568 | 63463100 |
Sterile pyuria | 81.83 | 24.78 | 12 | 11342 | 15 | 63477653 |
Gene mutation | 81.67 | 24.78 | 24 | 11330 | 1641 | 63476027 |
Impaired work ability | 80.91 | 24.78 | 46 | 11308 | 17429 | 63460239 |
Unwanted awareness during anaesthesia | 78.94 | 24.78 | 17 | 11337 | 321 | 63477347 |
Lymphoedema | 77.26 | 24.78 | 39 | 11315 | 11653 | 63466015 |
Arthralgia | 76.54 | 24.78 | 7 | 11347 | 569703 | 62907965 |
Agitation | 76.21 | 24.78 | 72 | 11282 | 59685 | 63417983 |
Delirium | 74.40 | 24.78 | 66 | 11288 | 50475 | 63427193 |
Off label use | 74.16 | 24.78 | 276 | 11078 | 674186 | 62803482 |
Hypercapnia | 73.92 | 24.78 | 30 | 11324 | 5401 | 63472267 |
Cardio-respiratory arrest | 72.21 | 24.78 | 70 | 11284 | 59889 | 63417779 |
Blood pH decreased | 71.26 | 24.78 | 24 | 11330 | 2563 | 63475105 |
Hyperlipidaemia | 70.96 | 24.78 | 44 | 11310 | 19527 | 63458141 |
CSF oligoclonal band present | 70.65 | 24.78 | 16 | 11338 | 384 | 63477284 |
Reduced bladder capacity | 68.67 | 24.78 | 9 | 11345 | 0 | 63477668 |
Intestinal ischaemia | 64.73 | 24.78 | 30 | 11324 | 7438 | 63470230 |
Hyperaesthesia | 64.14 | 24.78 | 32 | 11322 | 9326 | 63468342 |
Shock | 63.67 | 24.78 | 44 | 11310 | 23419 | 63454249 |
Allergy test negative | 63.43 | 24.78 | 13 | 11341 | 191 | 63477477 |
Cardiac arrest | 62.78 | 24.78 | 80 | 11274 | 92465 | 63385203 |
Oral herpes | 61.75 | 24.78 | 45 | 11309 | 26029 | 63451639 |
Bladder hypertrophy | 61.32 | 24.78 | 13 | 11341 | 227 | 63477441 |
Intestinal infarction | 59.80 | 24.78 | 17 | 11337 | 1033 | 63476635 |
Systemic inflammatory response syndrome | 59.61 | 24.78 | 26 | 11328 | 5595 | 63472073 |
Skin disorder | 58.95 | 24.78 | 46 | 11308 | 29461 | 63448207 |
Pleocytosis | 58.76 | 24.78 | 16 | 11338 | 829 | 63476839 |
Type I hypersensitivity | 56.97 | 24.78 | 21 | 11333 | 2921 | 63474747 |
Respiratory acidosis | 55.18 | 24.78 | 26 | 11328 | 6689 | 63470979 |
Biliary tract disorder | 54.45 | 24.78 | 15 | 11339 | 812 | 63476856 |
Venoocclusive liver disease | 53.35 | 24.78 | 23 | 11331 | 4812 | 63472856 |
Local anaesthetic systemic toxicity | 53.21 | 24.78 | 15 | 11339 | 884 | 63476784 |
Airway peak pressure increased | 53.18 | 24.78 | 12 | 11342 | 283 | 63477385 |
Partial seizures | 52.29 | 24.78 | 24 | 11330 | 5818 | 63471850 |
Cystitis | 51.34 | 24.78 | 56 | 11298 | 54935 | 63422733 |
Hepatocellular injury | 51.08 | 24.78 | 41 | 11313 | 27340 | 63450328 |
Contracted bladder | 50.91 | 24.78 | 7 | 11347 | 3 | 63477665 |
Stress cardiomyopathy | 49.54 | 24.78 | 27 | 11327 | 9423 | 63468245 |
Metabolic acidosis | 49.39 | 24.78 | 50 | 11304 | 45019 | 63432649 |
Headache | 49.33 | 24.78 | 26 | 11328 | 633215 | 62844453 |
Sleep apnoea syndrome | 48.85 | 24.78 | 41 | 11313 | 29092 | 63448576 |
Cholestasis | 48.48 | 24.78 | 41 | 11313 | 29393 | 63448275 |
PCO2 increased | 48.46 | 24.78 | 15 | 11339 | 1224 | 63476444 |
Acute generalised exanthematous pustulosis | 48.12 | 24.78 | 28 | 11326 | 11071 | 63466597 |
Lung hyperinflation | 47.80 | 24.78 | 15 | 11339 | 1280 | 63476388 |
Ultrasound ovary abnormal | 47.29 | 24.78 | 9 | 11345 | 88 | 63477580 |
Tachycardia | 46.46 | 24.78 | 79 | 11275 | 118077 | 63359591 |
Anaphylactoid shock | 46.34 | 24.78 | 11 | 11343 | 326 | 63477342 |
Abdominal discomfort | 45.66 | 24.78 | 3 | 11351 | 320882 | 63156786 |
Tinnitus | 45.53 | 24.78 | 43 | 11311 | 35585 | 63442083 |
Miosis | 44.15 | 24.78 | 23 | 11331 | 7330 | 63470338 |
PO2 decreased | 41.59 | 24.78 | 14 | 11340 | 1492 | 63476176 |
Blood creatine phosphokinase increased | 41.34 | 24.78 | 38 | 11316 | 30392 | 63447276 |
Perforation | 40.76 | 24.78 | 13 | 11341 | 1170 | 63476498 |
Alopecia | 40.64 | 24.78 | 6 | 11348 | 337530 | 63140138 |
Status asthmaticus | 39.85 | 24.78 | 12 | 11342 | 892 | 63476776 |
Lower urinary tract symptoms | 39.79 | 24.78 | 7 | 11347 | 42 | 63477626 |
Ureteric stenosis | 39.49 | 24.78 | 11 | 11343 | 620 | 63477048 |
Tonic clonic movements | 38.29 | 24.78 | 13 | 11341 | 1422 | 63476246 |
Ureteral polyp | 38.15 | 24.78 | 5 | 11349 | 0 | 63477668 |
Cystitis ulcerative | 38.15 | 24.78 | 5 | 11349 | 0 | 63477668 |
Intensive care unit acquired weakness | 36.63 | 24.78 | 11 | 11343 | 810 | 63476858 |
Hallucination | 36.53 | 24.78 | 47 | 11307 | 54770 | 63422898 |
Immune thrombocytopenia | 36.41 | 24.78 | 23 | 11331 | 10533 | 63467135 |
Nausea | 36.17 | 24.78 | 61 | 11293 | 854410 | 62623258 |
Arrhythmia | 35.87 | 24.78 | 39 | 11315 | 38101 | 63439567 |
Blood bicarbonate decreased | 35.79 | 24.78 | 15 | 11339 | 2926 | 63474742 |
Diastolic hypotension | 35.02 | 24.78 | 7 | 11347 | 90 | 63477578 |
Renal infarct | 34.31 | 24.78 | 12 | 11342 | 1435 | 63476233 |
Sedation | 33.59 | 24.78 | 38 | 11316 | 38771 | 63438897 |
Generalised tonic-clonic seizure | 33.27 | 24.78 | 33 | 11321 | 28983 | 63448685 |
Intensive care unit delirium | 32.38 | 24.78 | 6 | 11348 | 50 | 63477618 |
Encephalitis | 32.27 | 24.78 | 20 | 11334 | 8860 | 63468808 |
Bladder disorder | 32.13 | 24.78 | 20 | 11334 | 8926 | 63468742 |
Bladder necrosis | 32.03 | 24.78 | 5 | 11349 | 12 | 63477656 |
Post procedural stroke | 31.87 | 24.78 | 6 | 11348 | 55 | 63477613 |
Drug intolerance | 31.85 | 24.78 | 8 | 11346 | 308653 | 63169015 |
Drug use disorder | 31.10 | 24.78 | 16 | 11338 | 4968 | 63472700 |
Cataract | 30.56 | 24.78 | 44 | 11310 | 57009 | 63420659 |
Reversible cerebral vasoconstriction syndrome | 30.50 | 24.78 | 13 | 11341 | 2645 | 63475023 |
Pain | 30.27 | 24.78 | 54 | 11300 | 740574 | 62737094 |
Left ventricular hypertrophy | 30.13 | 24.78 | 16 | 11338 | 5299 | 63472369 |
Bradypnoea | 29.95 | 24.78 | 14 | 11340 | 3536 | 63474132 |
Hepatotoxicity | 29.92 | 24.78 | 35 | 11319 | 37006 | 63440662 |
Euthyroid sick syndrome | 29.89 | 24.78 | 6 | 11348 | 79 | 63477589 |
Nasopharyngitis | 29.50 | 24.78 | 5 | 11349 | 254252 | 63223416 |
Drug withdrawal syndrome | 29.48 | 24.78 | 30 | 11324 | 27164 | 63450504 |
Rheumatoid arthritis | 29.43 | 24.78 | 5 | 11349 | 253814 | 63223854 |
Cystitis interstitial | 29.38 | 24.78 | 11 | 11343 | 1597 | 63476071 |
Urinary tract disorder | 29.23 | 24.78 | 13 | 11341 | 2928 | 63474740 |
Peripheral swelling | 29.21 | 24.78 | 6 | 11348 | 265936 | 63211732 |
Decreased appetite | 28.99 | 24.78 | 5 | 11349 | 251047 | 63226621 |
Mucocutaneous haemorrhage | 28.97 | 24.78 | 6 | 11348 | 93 | 63477575 |
Bradycardia | 28.81 | 24.78 | 49 | 11305 | 73178 | 63404490 |
Swelling | 28.67 | 24.78 | 7 | 11347 | 275371 | 63202297 |
Oxygen saturation decreased | 28.13 | 24.78 | 54 | 11300 | 88531 | 63389137 |
Tachyphylaxis | 27.73 | 24.78 | 7 | 11347 | 269 | 63477399 |
Fluid retention | 27.64 | 24.78 | 43 | 11311 | 59643 | 63418025 |
Toxicity to various agents | 26.79 | 24.78 | 101 | 11253 | 247149 | 63230519 |
Cyanosis | 26.68 | 24.78 | 23 | 11331 | 16912 | 63460756 |
Drug dependence | 26.52 | 24.78 | 27 | 11327 | 24456 | 63453212 |
Product dose omission issue | 26.33 | 24.78 | 5 | 11349 | 234308 | 63243360 |
Posterior reversible encephalopathy syndrome | 26.20 | 24.78 | 23 | 11331 | 17322 | 63460346 |
Cellulitis | 26.07 | 24.78 | 50 | 11304 | 81908 | 63395760 |
Infusion related reaction | 26.03 | 24.78 | 6 | 11348 | 245515 | 63232153 |
Ureteral disorder | 25.99 | 24.78 | 7 | 11347 | 348 | 63477320 |
Cough | 25.88 | 24.78 | 10 | 11344 | 292733 | 63184935 |
Poisoning deliberate | 25.74 | 24.78 | 19 | 11335 | 11199 | 63466469 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 536.34 | 22.31 | 195 | 10197 | 15746 | 34930793 |
Drug abuse | 200.54 | 22.31 | 193 | 10199 | 98903 | 34847636 |
Drug ineffective | 192.87 | 22.31 | 419 | 9973 | 456332 | 34490207 |
Sedation | 186.80 | 22.31 | 101 | 10291 | 20905 | 34925634 |
Nightmare | 144.32 | 22.31 | 75 | 10317 | 14316 | 34932223 |
Cystitis ulcerative | 128.20 | 22.31 | 18 | 10374 | 0 | 34946539 |
Hypotension | 124.72 | 22.31 | 230 | 10162 | 221419 | 34725120 |
Anaphylactic reaction | 95.21 | 22.31 | 78 | 10314 | 32223 | 34914316 |
Product used for unknown indication | 91.02 | 22.31 | 26 | 10366 | 957 | 34945582 |
Nephrolithiasis | 90.98 | 22.31 | 74 | 10318 | 30259 | 34916280 |
Bradycardia | 89.35 | 22.31 | 111 | 10281 | 75307 | 34871232 |
Bronchospasm | 82.72 | 22.31 | 47 | 10345 | 10684 | 34935855 |
Hydronephrosis | 81.60 | 22.31 | 46 | 10346 | 10300 | 34936239 |
Tachycardia | 79.13 | 22.31 | 111 | 10281 | 84661 | 34861878 |
Hyperaesthesia | 76.46 | 22.31 | 34 | 10358 | 4596 | 34941943 |
Sedation complication | 75.86 | 22.31 | 26 | 10366 | 1751 | 34944788 |
Off label use | 74.84 | 22.31 | 283 | 10109 | 419241 | 34527298 |
Biopsy bladder abnormal | 71.22 | 22.31 | 10 | 10382 | 0 | 34946539 |
Cystitis | 65.28 | 22.31 | 39 | 10353 | 9726 | 34936813 |
Cystitis interstitial | 64.39 | 22.31 | 14 | 10378 | 161 | 34946378 |
Delirium | 64.06 | 22.31 | 72 | 10320 | 43919 | 34902620 |
Agitation | 63.99 | 22.31 | 82 | 10310 | 57317 | 34889222 |
Behaviour disorder | 62.19 | 22.31 | 30 | 10362 | 4880 | 34941659 |
Reduced bladder capacity | 61.51 | 22.31 | 9 | 10383 | 3 | 34946536 |
Respiratory depression | 60.35 | 22.31 | 45 | 10347 | 16200 | 34930339 |
Drug screen positive | 58.90 | 22.31 | 27 | 10365 | 3916 | 34942623 |
Product use in unapproved indication | 52.55 | 22.31 | 111 | 10281 | 117388 | 34829151 |
Drug dependence | 52.26 | 22.31 | 49 | 10343 | 24168 | 34922371 |
Delayed recovery from anaesthesia | 51.57 | 22.31 | 16 | 10376 | 785 | 34945754 |
Cardiac arrest | 51.56 | 22.31 | 98 | 10294 | 96061 | 34850478 |
Anal inflammation | 51.54 | 22.31 | 18 | 10374 | 1282 | 34945257 |
Allergy test negative | 51.12 | 22.31 | 11 | 10381 | 120 | 34946419 |
Hyperhidrosis | 50.66 | 22.31 | 85 | 10307 | 75607 | 34870932 |
Contracted bladder | 50.06 | 22.31 | 8 | 10384 | 11 | 34946528 |
Diabetes insipidus | 49.95 | 22.31 | 22 | 10370 | 2906 | 34943633 |
Mydriasis | 48.62 | 22.31 | 29 | 10363 | 7208 | 34939331 |
Toxicity to various agents | 48.50 | 22.31 | 150 | 10242 | 200212 | 34746327 |
Cholestasis | 46.03 | 22.31 | 48 | 10344 | 26900 | 34919639 |
Fatigue | 45.55 | 22.31 | 27 | 10365 | 370626 | 34575913 |
Drug ineffective for unapproved indication | 45.53 | 22.31 | 45 | 10347 | 23670 | 34922869 |
SARS-CoV-2 test negative | 43.83 | 22.31 | 15 | 10377 | 1005 | 34945534 |
Pulseless electrical activity | 43.57 | 22.31 | 27 | 10365 | 7184 | 34939355 |
Dyspnoea | 42.81 | 22.31 | 30 | 10362 | 376752 | 34569787 |
Metabolic acidosis | 41.89 | 22.31 | 58 | 10334 | 43622 | 34902917 |
Pneumonia | 39.72 | 22.31 | 30 | 10362 | 362597 | 34583942 |
Propofol infusion syndrome | 36.86 | 22.31 | 13 | 10379 | 953 | 34945586 |
Miosis | 36.72 | 22.31 | 27 | 10365 | 9508 | 34937031 |
Hypercapnia | 36.50 | 22.31 | 20 | 10372 | 4235 | 34942304 |
Abdominal compartment syndrome | 33.24 | 22.31 | 12 | 10380 | 941 | 34945598 |
Biliary dilatation | 32.70 | 22.31 | 12 | 10380 | 986 | 34945553 |
Diarrhoea | 32.58 | 22.31 | 41 | 10351 | 389871 | 34556668 |
Hypoventilation | 31.94 | 22.31 | 17 | 10375 | 3397 | 34943142 |
Circulatory collapse | 31.57 | 22.31 | 35 | 10357 | 21003 | 34925536 |
Intentional product misuse | 31.53 | 22.31 | 52 | 10340 | 45559 | 34900980 |
Hyperammonaemia | 31.45 | 22.31 | 21 | 10371 | 6346 | 34940193 |
Drug use disorder | 31.33 | 22.31 | 18 | 10374 | 4173 | 34942366 |
Accidental death | 31.08 | 22.31 | 15 | 10377 | 2441 | 34944098 |
Hyperarousal | 31.06 | 22.31 | 6 | 10386 | 36 | 34946503 |
Accident | 30.75 | 22.31 | 19 | 10373 | 5028 | 34941511 |
Anaphylactoid shock | 30.33 | 22.31 | 9 | 10383 | 379 | 34946160 |
Wolff-Parkinson-White syndrome | 30.31 | 22.31 | 8 | 10384 | 218 | 34946321 |
Substance abuse | 30.24 | 22.31 | 22 | 10370 | 7619 | 34938920 |
Rhabdomyolysis | 29.96 | 22.31 | 64 | 10328 | 68099 | 34878440 |
Urinary tract disorder | 29.41 | 22.31 | 14 | 10378 | 2210 | 34944329 |
Hypoxia | 29.30 | 22.31 | 56 | 10336 | 55039 | 34891500 |
Disorientation | 28.76 | 22.31 | 42 | 10350 | 33146 | 34913393 |
Biliary tract disorder | 28.63 | 22.31 | 11 | 10381 | 1027 | 34945512 |
Anaemia | 28.59 | 22.31 | 17 | 10375 | 233318 | 34713221 |
Ureteral polyp | 28.49 | 22.31 | 4 | 10388 | 0 | 34946539 |
Hypertonia | 28.48 | 22.31 | 17 | 10375 | 4229 | 34942310 |
Airway complication of anaesthesia | 28.12 | 22.31 | 7 | 10385 | 150 | 34946389 |
Aggression | 27.71 | 22.31 | 45 | 10347 | 38919 | 34907620 |
Cholangiolitis | 27.57 | 22.31 | 5 | 10387 | 20 | 34946519 |
Bladder disorder | 26.88 | 22.31 | 15 | 10377 | 3289 | 34943250 |
Haematuria traumatic | 26.48 | 22.31 | 7 | 10385 | 192 | 34946347 |
Axillary pain | 26.14 | 22.31 | 8 | 10384 | 375 | 34946164 |
Apnoea | 25.95 | 22.31 | 19 | 10373 | 6645 | 34939894 |
Type I hypersensitivity | 25.91 | 22.31 | 11 | 10381 | 1328 | 34945211 |
Asthenia | 25.90 | 22.31 | 21 | 10371 | 245230 | 34701309 |
Neonatal hypoxia | 25.66 | 22.31 | 8 | 10384 | 399 | 34946140 |
Brief psychotic disorder with marked stressors | 25.44 | 22.31 | 7 | 10385 | 224 | 34946315 |
Coma | 24.99 | 22.31 | 47 | 10345 | 45631 | 34900908 |
Laryngospasm | 24.57 | 22.31 | 11 | 10381 | 1510 | 34945029 |
Headache | 24.04 | 22.31 | 15 | 10377 | 200620 | 34745919 |
Paradoxical drug reaction | 24.01 | 22.31 | 14 | 10378 | 3337 | 34943202 |
Diastolic hypertension | 23.91 | 22.31 | 5 | 10387 | 47 | 34946492 |
Complication of device removal | 23.28 | 22.31 | 5 | 10387 | 54 | 34946485 |
Myocardial infarction | 23.26 | 22.31 | 4 | 10388 | 121081 | 34825458 |
Cardio-respiratory arrest | 23.25 | 22.31 | 51 | 10341 | 55222 | 34891317 |
Drug tolerance | 23.22 | 22.31 | 13 | 10379 | 2869 | 34943670 |
Transcranial electrical motor evoked potential monitoring abnormal | 22.94 | 22.31 | 4 | 10388 | 12 | 34946527 |
Multiple-drug resistance | 22.84 | 22.31 | 16 | 10376 | 5223 | 34941316 |
Anaesthetic complication neurological | 22.79 | 22.31 | 7 | 10385 | 332 | 34946207 |
Chest pain | 22.64 | 22.31 | 5 | 10387 | 126757 | 34819782 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic shock | 1102.69 | 18.94 | 398 | 20595 | 35598 | 79687797 |
Drug abuse | 288.01 | 18.94 | 279 | 20714 | 162412 | 79560983 |
Drug ineffective | 279.70 | 18.94 | 763 | 20230 | 1080150 | 78643245 |
Hypotension | 213.30 | 18.94 | 400 | 20593 | 439917 | 79283478 |
Bronchospasm | 204.39 | 18.94 | 109 | 20884 | 24750 | 79698645 |
Hydronephrosis | 197.54 | 18.94 | 95 | 20898 | 17359 | 79706036 |
Propofol infusion syndrome | 187.85 | 18.94 | 52 | 20941 | 1931 | 79721464 |
Drug ineffective for unapproved indication | 187.50 | 18.94 | 134 | 20859 | 51104 | 79672291 |
Anaphylactic reaction | 175.67 | 18.94 | 158 | 20835 | 83585 | 79639810 |
Cystitis ulcerative | 166.59 | 18.94 | 23 | 20970 | 0 | 79723395 |
Sedation | 154.68 | 18.94 | 120 | 20873 | 51775 | 79671620 |
Body tinea | 150.11 | 18.94 | 43 | 20950 | 1811 | 79721584 |
Agitation | 132.84 | 18.94 | 147 | 20846 | 99568 | 79623827 |
Reduced bladder capacity | 130.38 | 18.94 | 18 | 20975 | 0 | 79723395 |
Hyperaesthesia | 127.70 | 18.94 | 63 | 20930 | 12159 | 79711236 |
Respiratory depression | 121.63 | 18.94 | 81 | 20912 | 27549 | 79695846 |
Multiple-drug resistance | 121.53 | 18.94 | 55 | 20938 | 8753 | 79714642 |
Off label use | 121.41 | 18.94 | 515 | 20478 | 906700 | 78816695 |
Mitochondrial DNA mutation | 120.75 | 18.94 | 27 | 20966 | 406 | 79722989 |
Infection susceptibility increased | 120.64 | 18.94 | 43 | 20950 | 3678 | 79719717 |
Oesophageal spasm | 119.90 | 18.94 | 42 | 20951 | 3414 | 79719981 |
Arthralgia | 119.54 | 18.94 | 8 | 20985 | 571795 | 79151600 |
Biliary dilatation | 116.74 | 18.94 | 39 | 20954 | 2747 | 79720648 |
Tachycardia | 113.79 | 18.94 | 183 | 20810 | 177585 | 79545810 |
Dilatation intrahepatic duct acquired | 111.39 | 18.94 | 28 | 20965 | 710 | 79722685 |
Oesophageal pain | 111.15 | 18.94 | 42 | 20951 | 4237 | 79719158 |
Cardiac arrest | 109.92 | 18.94 | 177 | 20816 | 171919 | 79551476 |
Inhibitory drug interaction | 109.52 | 18.94 | 42 | 20951 | 4411 | 79718984 |
Bradycardia | 107.20 | 18.94 | 154 | 20839 | 135403 | 79587992 |
Delirium | 106.26 | 18.94 | 121 | 20872 | 84506 | 79638889 |
Allergy test negative | 105.14 | 18.94 | 23 | 20970 | 311 | 79723084 |
Intra-abdominal pressure increased | 103.46 | 18.94 | 22 | 20971 | 258 | 79723137 |
Hypercapnia | 102.19 | 18.94 | 49 | 20944 | 8886 | 79714509 |
Cystitis | 101.75 | 18.94 | 95 | 20898 | 52637 | 79670758 |
Nightmare | 95.39 | 18.94 | 68 | 20925 | 25793 | 79697602 |
Contracted bladder | 91.70 | 18.94 | 14 | 20979 | 14 | 79723381 |
Cholestasis | 89.41 | 18.94 | 88 | 20905 | 52021 | 79671374 |
Glucose tolerance impaired | 88.42 | 18.94 | 43 | 20950 | 8041 | 79715354 |
Metabolic acidosis | 87.10 | 18.94 | 108 | 20885 | 82421 | 79640974 |
Sterile pyuria | 83.74 | 18.94 | 15 | 20978 | 64 | 79723331 |
Product used for unknown indication | 82.54 | 18.94 | 26 | 20967 | 1518 | 79721877 |
Headache | 81.81 | 18.94 | 35 | 20958 | 653737 | 79069658 |
Cystitis interstitial | 81.11 | 18.94 | 25 | 20968 | 1358 | 79722037 |
Bladder hypertrophy | 79.90 | 18.94 | 21 | 20972 | 638 | 79722757 |
Poor quality sleep | 79.81 | 18.94 | 58 | 20935 | 22664 | 79700731 |
Drug dependence | 79.71 | 18.94 | 74 | 20919 | 40695 | 79682700 |
Biopsy bladder abnormal | 79.67 | 18.94 | 11 | 20982 | 0 | 79723395 |
Miosis | 78.57 | 18.94 | 50 | 20943 | 15739 | 79707656 |
Pneumatosis | 78.20 | 18.94 | 22 | 20971 | 867 | 79722528 |
Type I hypersensitivity | 75.40 | 18.94 | 32 | 20961 | 4366 | 79719029 |
Cardio-respiratory arrest | 73.91 | 18.94 | 115 | 20878 | 108395 | 79615000 |
Necrosis ischaemic | 73.77 | 18.94 | 22 | 20971 | 1068 | 79722327 |
Shock | 71.85 | 18.94 | 72 | 20921 | 43476 | 79679919 |
Anaphylactoid shock | 71.77 | 18.94 | 20 | 20973 | 761 | 79722634 |
Behaviour disorder | 70.31 | 18.94 | 34 | 20959 | 6279 | 79717116 |
Blood lactic acid increased | 70.08 | 18.94 | 43 | 20950 | 12701 | 79710694 |
Respiratory acidosis | 69.91 | 18.94 | 41 | 20952 | 11159 | 79712236 |
Lymphoedema | 68.55 | 18.94 | 42 | 20951 | 12371 | 79711024 |
Bone density decreased | 68.25 | 18.94 | 43 | 20950 | 13304 | 79710091 |
Blood gases abnormal | 67.81 | 18.94 | 21 | 20972 | 1159 | 79722236 |
Impaired quality of life | 67.74 | 18.94 | 44 | 20949 | 14342 | 79709053 |
Diabetes insipidus | 66.90 | 18.94 | 31 | 20962 | 5206 | 79718189 |
Ureteral polyp | 65.19 | 18.94 | 9 | 20984 | 0 | 79723395 |
Dyspnoea | 64.23 | 18.94 | 79 | 20914 | 856946 | 78866449 |
Status epilepticus | 64.12 | 18.94 | 53 | 20940 | 24988 | 79698407 |
CSF oligoclonal band present | 63.67 | 18.94 | 16 | 20977 | 405 | 79722990 |
Gene mutation | 61.31 | 18.94 | 24 | 20969 | 2662 | 79720733 |
Sedation complication | 59.63 | 18.94 | 42 | 20951 | 15627 | 79707768 |
Bladder disorder | 58.39 | 18.94 | 34 | 20959 | 9131 | 79714264 |
Unwanted awareness during anaesthesia | 57.41 | 18.94 | 14 | 20979 | 312 | 79723083 |
Product use in unapproved indication | 57.25 | 18.94 | 170 | 20823 | 250189 | 79473206 |
Biliary tract disorder | 56.87 | 18.94 | 20 | 20973 | 1644 | 79721751 |
Urinary tract disorder | 56.85 | 18.94 | 25 | 20968 | 3717 | 79719678 |
Drug screen positive | 56.71 | 18.94 | 29 | 20964 | 6034 | 79717361 |
Impaired work ability | 55.34 | 18.94 | 44 | 20949 | 19637 | 79703758 |
Mydriasis | 55.16 | 18.94 | 42 | 20951 | 17601 | 79705794 |
Joint swelling | 54.87 | 18.94 | 6 | 20987 | 288640 | 79434755 |
Intensive care unit acquired weakness | 53.94 | 18.94 | 20 | 20973 | 1913 | 79721482 |
Purpura | 53.51 | 18.94 | 43 | 20950 | 19484 | 79703911 |
Hepatocellular injury | 52.97 | 18.94 | 64 | 20929 | 47529 | 79675866 |
Lower urinary tract symptoms | 52.56 | 18.94 | 12 | 20981 | 199 | 79723196 |
Drug use disorder | 52.24 | 18.94 | 31 | 20962 | 8620 | 79714775 |
Laryngospasm | 52.12 | 18.94 | 24 | 20969 | 3973 | 79719422 |
Nephrolithiasis | 51.86 | 18.94 | 67 | 20926 | 53224 | 79670171 |
Airway peak pressure increased | 51.59 | 18.94 | 13 | 20980 | 333 | 79723062 |
Asthenia | 51.43 | 18.94 | 36 | 20957 | 511653 | 79211742 |
Partial seizures | 51.17 | 18.94 | 31 | 20962 | 8947 | 79714448 |
Abdominal discomfort | 50.88 | 18.94 | 4 | 20989 | 250723 | 79472672 |
Intestinal infarction | 49.29 | 18.94 | 17 | 20976 | 1319 | 79722076 |
Delayed recovery from anaesthesia | 49.24 | 18.94 | 18 | 20975 | 1655 | 79721740 |
Intestinal ischaemia | 49.17 | 18.94 | 35 | 20958 | 13235 | 79710160 |
Diarrhoea | 48.99 | 18.94 | 99 | 20894 | 880390 | 78843005 |
Nasopharyngitis | 48.96 | 18.94 | 5 | 20988 | 253876 | 79469519 |
Anal inflammation | 48.16 | 18.94 | 17 | 20976 | 1413 | 79721982 |
Hyperhidrosis | 45.75 | 18.94 | 114 | 20879 | 151378 | 79572017 |
Sleep apnoea syndrome | 45.48 | 18.94 | 52 | 20941 | 36426 | 79686969 |
Status asthmaticus | 45.42 | 18.94 | 15 | 20978 | 1019 | 79722376 |
Hallucination | 45.15 | 18.94 | 81 | 20912 | 85664 | 79637731 |
Local anaesthetic systemic toxicity | 45.13 | 18.94 | 15 | 20978 | 1039 | 79722356 |
Pleocytosis | 44.28 | 18.94 | 16 | 20977 | 1423 | 79721972 |
Circulatory collapse | 44.13 | 18.94 | 52 | 20941 | 37616 | 79685779 |
Hypoxia | 43.84 | 18.94 | 89 | 20904 | 103154 | 79620241 |
Ultrasound ovary abnormal | 43.81 | 18.94 | 9 | 20984 | 88 | 79723307 |
Peripheral swelling | 43.48 | 18.94 | 9 | 20984 | 269608 | 79453787 |
Alopecia | 43.48 | 18.94 | 5 | 20988 | 231350 | 79492045 |
Hyperlipidaemia | 42.77 | 18.94 | 43 | 20950 | 26050 | 79697345 |
Oral herpes | 42.74 | 18.94 | 44 | 20949 | 27410 | 79695985 |
Stress cardiomyopathy | 42.65 | 18.94 | 30 | 20963 | 11136 | 79712259 |
Cough | 42.15 | 18.94 | 22 | 20971 | 366767 | 79356628 |
Intentional product misuse | 41.56 | 18.94 | 83 | 20910 | 95082 | 79628313 |
Hypoventilation | 41.32 | 18.94 | 25 | 20968 | 7199 | 79716196 |
SARS-CoV-2 test negative | 41.27 | 18.94 | 15 | 20978 | 1356 | 79722039 |
Ureteric stenosis | 41.05 | 18.94 | 15 | 20978 | 1377 | 79722018 |
Haemodynamic instability | 40.81 | 18.94 | 35 | 20958 | 17347 | 79706048 |
Drug withdrawal syndrome | 40.79 | 18.94 | 48 | 20945 | 34670 | 79688725 |
Ureteral disorder | 40.67 | 18.94 | 12 | 20981 | 561 | 79722834 |
Rheumatoid arthritis | 40.47 | 18.94 | 4 | 20989 | 208466 | 79514929 |
Lung hyperinflation | 40.29 | 18.94 | 16 | 20977 | 1843 | 79721552 |
Drug intolerance | 40.22 | 18.94 | 10 | 20983 | 264109 | 79459286 |
Decreased appetite | 40.15 | 18.94 | 20 | 20973 | 342398 | 79380997 |
Swelling | 39.94 | 18.94 | 5 | 20988 | 216706 | 79506689 |
Airway complication of anaesthesia | 39.71 | 18.94 | 11 | 20982 | 409 | 79722986 |
Blood pH decreased | 39.66 | 18.94 | 21 | 20972 | 4690 | 79718705 |
Chest pain | 38.74 | 18.94 | 13 | 20980 | 282291 | 79441104 |
Oedema peripheral | 37.56 | 18.94 | 10 | 20983 | 252278 | 79471117 |
Tonic clonic movements | 37.24 | 18.94 | 16 | 20977 | 2248 | 79721147 |
Disease progression | 37.23 | 18.94 | 3 | 20990 | 184359 | 79539036 |
PCO2 increased | 36.98 | 18.94 | 15 | 20978 | 1825 | 79721570 |
Skin disorder | 36.71 | 18.94 | 45 | 20948 | 33898 | 79689497 |
Pain in extremity | 36.13 | 18.94 | 26 | 20967 | 364512 | 79358883 |
Tinnitus | 35.92 | 18.94 | 51 | 20942 | 44282 | 79679113 |
Toxicity to various agents | 35.80 | 18.94 | 211 | 20782 | 421329 | 79302066 |
Anaemia | 35.40 | 18.94 | 39 | 20954 | 444976 | 79278419 |
Systemic inflammatory response syndrome | 35.19 | 18.94 | 27 | 20966 | 11438 | 79711957 |
Anaesthetic complication neurological | 35.07 | 18.94 | 11 | 20982 | 633 | 79722762 |
Apnoea | 34.70 | 18.94 | 27 | 20966 | 11677 | 79711718 |
Product dose omission issue | 34.67 | 18.94 | 11 | 20982 | 247526 | 79475869 |
Venoocclusive liver disease | 34.56 | 18.94 | 27 | 20966 | 11744 | 79711651 |
Infusion related reaction | 34.51 | 18.94 | 9 | 20984 | 230228 | 79493167 |
Weight decreased | 34.34 | 18.94 | 26 | 20967 | 355172 | 79368223 |
Pulseless electrical activity | 34.24 | 18.94 | 29 | 20964 | 14131 | 79709264 |
Perforation | 33.46 | 18.94 | 13 | 20980 | 1413 | 79721982 |
Withdrawal syndrome | 33.00 | 18.94 | 38 | 20955 | 26816 | 79696579 |
Arthropathy | 32.85 | 18.94 | 4 | 20989 | 177107 | 79546288 |
Drug abuser | 32.32 | 18.94 | 20 | 20973 | 5993 | 79717402 |
Blood creatine phosphokinase increased | 31.72 | 18.94 | 60 | 20933 | 66030 | 79657365 |
Coma | 31.70 | 18.94 | 77 | 20916 | 100572 | 79622823 |
Dehydration | 31.41 | 18.94 | 13 | 20980 | 248174 | 79475221 |
Fall | 31.37 | 18.94 | 50 | 20943 | 487579 | 79235816 |
Acute generalised exanthematous pustulosis | 31.19 | 18.94 | 30 | 20963 | 17224 | 79706171 |
Substance abuse | 30.59 | 18.94 | 24 | 20969 | 10502 | 79712893 |
Accidental death | 30.23 | 18.94 | 17 | 20976 | 4274 | 79719121 |
Drug tolerance | 30.13 | 18.94 | 22 | 20971 | 8653 | 79714742 |
Intensive care unit delirium | 29.56 | 18.94 | 6 | 20987 | 55 | 79723340 |
Rhabdomyolysis | 29.44 | 18.94 | 76 | 20917 | 103055 | 79620340 |
Urinary tract infection | 29.32 | 18.94 | 18 | 20975 | 274494 | 79448901 |
Paradoxical drug reaction | 29.07 | 18.94 | 20 | 20973 | 7165 | 79716230 |
Transcranial electrical motor evoked potential monitoring abnormal | 29.04 | 18.94 | 5 | 20988 | 16 | 79723379 |
Wolff-Parkinson-White syndrome | 28.95 | 18.94 | 8 | 20985 | 295 | 79723100 |
Bladder necrosis | 28.81 | 18.94 | 5 | 20988 | 17 | 79723378 |
Abdominal compartment syndrome | 28.64 | 18.94 | 12 | 20981 | 1585 | 79721810 |
Dissociative disorder | 28.56 | 18.94 | 10 | 20983 | 811 | 79722584 |
Fatigue | 28.54 | 18.94 | 137 | 20856 | 929590 | 78793805 |
Diastolic hypotension | 27.86 | 18.94 | 7 | 20986 | 177 | 79723218 |
Haematuria traumatic | 27.39 | 18.94 | 7 | 20986 | 190 | 79723205 |
Cholangiolitis | 27.26 | 18.94 | 5 | 20988 | 25 | 79723370 |
PO2 decreased | 27.21 | 18.94 | 14 | 20979 | 2949 | 79720446 |
Euthyroid sick syndrome | 26.85 | 18.94 | 6 | 20987 | 90 | 79723305 |
Hypertonia | 26.62 | 18.94 | 19 | 20974 | 7213 | 79716182 |
Hyperarousal | 26.49 | 18.94 | 5 | 20988 | 30 | 79723365 |
Dysphoria | 26.09 | 18.94 | 16 | 20977 | 4718 | 79718677 |
Antisocial behaviour | 25.92 | 18.94 | 9 | 20984 | 712 | 79722683 |
Paralysis | 25.90 | 18.94 | 24 | 20969 | 13153 | 79710242 |
Post procedural stroke | 25.82 | 18.94 | 6 | 20987 | 108 | 79723287 |
Accident | 25.37 | 18.94 | 20 | 20973 | 8811 | 79714584 |
Macroglossia | 25.02 | 18.94 | 10 | 20983 | 1171 | 79722224 |
Bradypnoea | 24.85 | 18.94 | 17 | 20976 | 6035 | 79717360 |
Acidosis | 24.34 | 18.94 | 28 | 20965 | 19734 | 79703661 |
Brief psychotic disorder with marked stressors | 24.27 | 18.94 | 7 | 20986 | 302 | 79723093 |
Pyuria | 24.19 | 18.94 | 12 | 20981 | 2340 | 79721055 |
Multiple organ dysfunction syndrome | 24.05 | 18.94 | 78 | 20915 | 120168 | 79603227 |
Injection site pain | 23.90 | 18.94 | 3 | 20990 | 129835 | 79593560 |
Pneumonia | 23.44 | 18.94 | 92 | 20901 | 660154 | 79063241 |
Hyperammonaemia | 23.36 | 18.94 | 21 | 20972 | 11072 | 79712323 |
Upper airway obstruction | 23.19 | 18.94 | 10 | 20983 | 1418 | 79721977 |
General physical health deterioration | 23.12 | 18.94 | 23 | 20970 | 275215 | 79448180 |
Myalgia | 23.04 | 18.94 | 10 | 20983 | 185631 | 79537764 |
Aggression | 22.90 | 18.94 | 45 | 20948 | 50913 | 79672482 |
Cholangitis sclerosing | 22.90 | 18.94 | 12 | 20981 | 2625 | 79720770 |
Neuromuscular block prolonged | 22.79 | 18.94 | 9 | 20984 | 1021 | 79722374 |
Arrhythmia | 22.72 | 18.94 | 50 | 20943 | 61222 | 79662173 |
Renal infarct | 22.67 | 18.94 | 12 | 20981 | 2679 | 79720716 |
Pain | 22.56 | 18.94 | 102 | 20891 | 703700 | 79019695 |
Depressed level of consciousness | 22.39 | 18.94 | 66 | 20927 | 96586 | 79626809 |
Blood bicarbonate decreased | 22.31 | 18.94 | 15 | 20978 | 5176 | 79718219 |
Mucocutaneous haemorrhage | 22.24 | 18.94 | 6 | 20987 | 202 | 79723193 |
Diastolic hypertension | 22.01 | 18.94 | 5 | 20988 | 81 | 79723314 |
Haemoglobin decreased | 21.78 | 18.94 | 16 | 20977 | 222103 | 79501292 |
Hepatotoxicity | 21.47 | 18.94 | 44 | 20949 | 51308 | 79672087 |
Aplastic anaemia | 21.43 | 18.94 | 25 | 20968 | 17880 | 79705515 |
Intentional product misuse to child | 21.41 | 18.94 | 5 | 20988 | 92 | 79723303 |
Therapy non-responder | 21.35 | 18.94 | 63 | 20930 | 92242 | 79631153 |
Reversible cerebral vasoconstriction syndrome | 21.23 | 18.94 | 12 | 20981 | 3045 | 79720350 |
Mania | 21.04 | 18.94 | 25 | 20968 | 18235 | 79705160 |
Oxygen saturation decreased | 20.85 | 18.94 | 78 | 20915 | 128969 | 79594426 |
Musculoskeletal stiffness | 20.83 | 18.94 | 10 | 20983 | 174998 | 79548397 |
Cyanosis | 20.44 | 18.94 | 29 | 20964 | 25153 | 79698242 |
Brain oedema | 20.37 | 18.94 | 29 | 20964 | 25234 | 79698161 |
Symptom masked | 20.19 | 18.94 | 9 | 20984 | 1381 | 79722014 |
Encephalitis | 20.04 | 18.94 | 22 | 20971 | 14738 | 79708657 |
Mobility decreased | 19.84 | 18.94 | 4 | 20989 | 122171 | 79601224 |
Disorientation | 19.73 | 18.94 | 48 | 20945 | 62728 | 79660667 |
Back pain | 19.72 | 18.94 | 31 | 20962 | 304149 | 79419246 |
Nystagmus | 19.39 | 18.94 | 18 | 20975 | 9886 | 79713509 |
None
Source | Code | Description |
---|---|---|
ATC | N01AX03 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Other general anesthetics |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D000778 | Anesthetics, Dissociative |
MeSH PA | D018686 | Anesthetics, Intravenous |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018691 | Excitatory Amino Acid Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:38877 | intravenous anesthetics |
CHEBI has role | CHEBI:50910 | agente neurotoxico |
CHEBI has role | CHEBI:60643 | N-methyl-D-aspartate receptor antagonists |
CHEBI has role | CHEBI:78298 | environmental contaminants |
FDA EPC | N0000175681 | General Anesthetic |
FDA PE | N0000175975 | General Anesthesia |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
General anesthesia | indication | 50697003 | |
Local anesthesia | indication | 386761002 | |
Pain | off-label use | 22253000 | |
Inflammatory disease of mucous membrane | off-label use | 95361005 | |
Major depressive disorder | off-label use | 370143000 | |
Delirium | contraindication | 2776000 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Alcoholism | contraindication | 7200002 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Alcohol intoxication | contraindication | 25702006 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Decreased respiratory function | contraindication | 80954004 | |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Cerebrovascular accident | contraindication | 230690007 | |
Raised intracranial pressure | contraindication | 271719001 | DOID:9428 |
Cerebral trauma | contraindication | 275382005 | |
Impaired cognition | contraindication | 386806002 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Hypertensive urgency | contraindication | 443482000 | |
Psychiatric Disturbance | contraindication | ||
Cardiac Decompensation | contraindication |
Species | Use | Relation |
---|---|---|
Cats | Restraint | Indication |
Cats | Anesthesia in diagnostic or minor surgical procedures that do not require skeletal muscle relaxation | Indication |
Primates | Restraint | Indication |
Primates | Anesthesia in diagnostic or minor surgical procedures that do not require skeletal muscle relaxation | Indication |
Product | Applicant | Ingredients |
---|---|---|
Ketaset | Zoetis Inc. | 1 |
Ketaset, Vetalar | Boehringer lngelheim Animal Health USA Inc. | 1 |
Ketaset Plus | Zoetis Inc. | 3 |
Ketamine Hydrochloride Injection | Cronus Pharma Specialities India Private Limited | 1 |
Ketamine Hydrochloride Injection, USP | Elanco US Inc. | 1 |
VetaKet | Akorn Animal Health Inc. | 1 |
Ketamine Hydrochloride Injection, USP | Dechra Veterinary Products LLC | 1 |
Ketamine HCL | Mylan Institutional LLC, a Viatris Company | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.65 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glutamate [NMDA] receptor | Ion channel | BLOCKER | Ki | 6.38 | CHEMBL | CHEMBL | |||
Glutamate receptor ionotropic AMPA | Ion channel | OPENER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Acetylcholine receptor subunit alpha | Ion channel | IC50 | 5.31 | CHEMBL | |||||
Glutamate NMDA receptor | Ion channel | IC50 | 6.21 | CHEMBL |
ID | Source |
---|---|
4019796 | VUID |
N0000147885 | NUI |
D00711 | KEGG_DRUG |
1867-66-9 | SECONDARY_CAS_RN |
4018154 | VANDF |
4019796 | VANDF |
C0022614 | UMLSCUI |
CHEBI:6121 | CHEBI |
CHEMBL742 | ChEMBL_ID |
DB01221 | DRUGBANK_ID |
CHEMBL1714 | ChEMBL_ID |
D007649 | MESH_DESCRIPTOR_UI |
3821 | PUBCHEM_CID |
4233 | IUPHAR_LIGAND_ID |
2156 | INN_ID |
690G0D6V8H | UNII |
203184 | RXNORM |
4944 | MMSL |
9883 | MMSL |
d00272 | MMSL |
001403 | NDDF |
004581 | NDDF |
31706007 | SNOMEDCT_US |
333847008 | SNOMEDCT_US |
373464007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9508 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9508 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9509 | INJECTION | 100 mg | INTRAMUSCULAR | ANDA | 27 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9509 | INJECTION | 100 mg | INTRAMUSCULAR | ANDA | 27 sections |
KETALAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9880 | INJECTION | 10 mg | INTRAVENOUS | NDA | 17 sections |
KETALAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9880 | INJECTION | 10 mg | INTRAVENOUS | NDA | 17 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9881 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 19 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9881 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 19 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9881 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 19 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9882 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAMUSCULAR | ANDA | 14 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9882 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAMUSCULAR | ANDA | 14 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0040 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0040 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2051 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2051 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2053 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAMUSCULAR | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2053 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAMUSCULAR | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-682 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-683 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 31 sections |
Ketamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-684 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 31 sections |
Ketalar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-113 | INJECTION | 10 mg | INTRAMUSCULAR | NDA | 27 sections |
Ketalar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-113 | INJECTION | 10 mg | INTRAMUSCULAR | NDA | 27 sections |
Ketalar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-114 | INJECTION | 50 mg | INTRAMUSCULAR | NDA | 27 sections |
Ketalar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-114 | INJECTION | 50 mg | INTRAMUSCULAR | NDA | 27 sections |
Ketalar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-115 | INJECTION | 100 mg | INTRAMUSCULAR | NDA | 27 sections |
Ketalar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-115 | INJECTION | 100 mg | INTRAMUSCULAR | NDA | 27 sections |
KETALAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-037 | INJECTION | 10 mg | INTRAVENOUS | NDA | 19 sections |
KETALAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-037 | INJECTION | 10 mg | INTRAVENOUS | NDA | 19 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-038 | INJECTION, SOLUTION, CONCENTRATE | 50 mg | INTRAMUSCULAR | ANDA | 14 sections |
KETAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-040 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAMUSCULAR | ANDA | 19 sections |