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indapamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, sulfamoylbenzoic acid derivatives	1433	26807-65-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: metindamide indapamide hemihydrate indapamide flupamid indaflex indamide indamol veroxil (+/-)-Indapamide	A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS. Molecular weight: 365.83 Formula: C16H16ClN3O3S CLOGP: 2.96 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 92.50 ALOGS: -4.03 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

metindamide
indapamide hemihydrate
indapamide
flupamid
indaflex
indamide
indamol
veroxil
(+/-)-Indapamide

A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.

Molecular weight: 365.83
Formula: C16H16ClN3O3S
CLOGP: 2.96
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 92.50
ALOGS: -4.03
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2.50	mg	O

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
EoM (Fraction excreted unchanged in urine)	7 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.59 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.20 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

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Approvals:

Date	Agency	Company	Orphan
July 6, 1983	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	1351.44	13.68	728	24851	111172	63352271
Hypokalaemia	543.03	13.68	398	25181	103406	63360037
Acute kidney injury	234.56	13.68	397	25182	263018	63200425
Inappropriate antidiuretic hormone secretion	186.77	13.68	101	25478	15361	63448082
Drug interaction	118.15	13.68	275	25304	228856	63234587
Hypomagnesaemia	110.39	13.68	92	25487	28645	63434798
Confusional state	109.30	13.68	272	25307	236108	63227335
Hypochloraemia	109.10	13.68	38	25541	1971	63461472
Burning mouth syndrome	85.68	13.68	23	25556	488	63462955
Hyponatraemic seizure	84.10	13.68	22	25557	421	63463022

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	274.54	13.88	267	17158	82424	34857082
Hypokalaemia	223.74	13.88	204	17221	58010	34881496
Acute kidney injury	135.90	13.88	395	17030	304593	34634913
Death	82.95	13.88	48	17377	398001	34541505
Hypomagnesaemia	78.79	13.88	74	17351	21777	34917729
Drug interaction	75.91	13.88	266	17159	225680	34713826
Bradycardia	45.85	13.88	110	17315	75308	34864198
Tachyarrhythmia	45.27	13.88	26	17399	3582	34935924
Hyperkalaemia	43.03	13.88	102	17323	69287	34870219
Atrial fibrillation	41.74	13.88	145	17280	122248	34817258

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	1375.05	11.94	943	39244	176905	79527296
Hypokalaemia	690.75	11.94	575	39612	143465	79560736
Acute kidney injury	330.20	11.94	774	39413	518630	79185571
Hypomagnesaemia	193.25	11.94	172	40015	46739	79657462
Drug interaction	172.19	11.94	529	39658	414654	79289547
Inappropriate antidiuretic hormone secretion	157.73	11.94	120	40067	26193	79678008
Death	106.83	11.94	78	40109	566436	79137765
Hypochloraemia	106.32	11.94	42	40145	2473	79701728
Completed suicide	106.30	11.94	4	40183	245763	79458438
Confusional state	104.64	11.94	375	39812	317622	79386579

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C03BA11	CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, EXCL. THIAZIDES Sulfonamides, plain
ATC	C09BX01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C10BX13	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
CHEBI has role	CHEBI:35498	diuretics
CHEBI has role	CHEBI:35674	antihypertensive drugs
FDA EPC	N0000175420	Thiazide-like Diuretic
FDA PE	N0000175359	Increased Diuresis
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Edema	indication	267038008
Anuria	contraindication	2472002	DOID:2983
Dehydration	contraindication	34095006
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Sympathectomy	contraindication	57071006
Acute nephropathy	contraindication	58574008
Hyperparathyroidism	contraindication	66999008	DOID:13543
Diabetes mellitus	contraindication	73211009	DOID:9351

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.53	acidic
pKa2	9.54	acidic
pKa3	5.52	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Solute carrier family 12 member 3	Transporter	P55017	S12A3_HUMAN	INHIBITOR	A2	7.54	WOMBAT-PK	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Kd	5	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	6.67	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	7.44	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	8	CHEMBL
Potassium voltage-gated channel subfamily KQT member 1	Ion channel	P51787	KCNQ1_HUMAN				WOMBAT-PK
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	6.05	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	6.56	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	9.64	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Kd	6.60	CHEMBL

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External reference:

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ID	Source
BL1	PDB_CHEM_ID
002313	NDDF
180004-24-4	SECONDARY_CAS_RN
2360	MMSL
3333	INN_ID
3702	PUBCHEM_CID
387419003	SNOMEDCT_US
4018746	VUID
4018746	VANDF
4873	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2571	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2571	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2571	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2597	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2597	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2597	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0069	TABLET, FILM COATED	1.25 mg	ORAL	ANDA	20 sections
Indapamide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0080	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	20 sections
Indapamide	Human Prescription Drug Label	1	16571-875	TABLET	1.25 mg	ORAL	ANDA	18 sections
Indapamide	Human Prescription Drug Label	1	16571-876	TABLET	2.50 mg	ORAL	ANDA	18 sections

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