AI ASSISTANT

Ask DrugCentral

Explore drug properties, targets, and indications with answers grounded in DrugCentral.

Your question

Ask in your own words. Each question is answered independently.

Explore sample questions

Select a question to fill the editor, then ask it or make it your own.

DrugCentral answer

Your answer will appear here. Open linked drug cards in a new tab to explore the source details.

AI can make mistakes. Verify answers against the original sources before relying on them.

Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	1316	56-81-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glycerol glycerin glycerine propane-1,2,3-triol 1,2,3-triglycerol glycyl alcohol	A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent. Molecular weight: 92.09 Formula: C3H8O3 CLOGP: -1.54 LIPINSKI: 0 HAC: 3 HDO: 3 TPSA: 60.69 ALOGS: 1.10 ROTB: 2

Molecule

Description

Molfile Inchi Smiles

Synonyms:

glycerol
glycerin
glycerine
propane-1,2,3-triol
1,2,3-triglycerol
glycyl alcohol

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.

Molecular weight: 92.09
Formula: C3H8O3
CLOGP: -1.54
LIPINSKI: 0
HAC: 3
HDO: 3
TPSA: 60.69
ALOGS: 1.10
ROTB: 2

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	500 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1	47
kinase-selectivity-class	ACVRL1,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK8,CDK9,CHUK,CLK2,DYRK1A,EPHB4,HASPIN,INSR,IRAK1,IRAK3,IRAK4,KIT,MAP2K6,MAP3K21,MAPK11,PIK3CD,PRKDC,SYK,TEK,TGFBR1,TYRO3,ZAP70	35
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
May 6, 1982	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	814.28	9.26	253	97760	3247	90527187
Macular degeneration	538.62	9.26	394	97619	37576	90492858
Pemphigus	291.69	9.26	15	97998	326849	90203585
Maternal exposure during delivery	291.05	9.26	121	97892	3725	90526709
Hand deformity	279.85	9.26	9	98004	296353	90234081
Systemic lupus erythematosus	270.13	9.26	36	97977	361860	90168574
Glossodynia	265.80	9.26	22	97991	321757	90208677
Synovitis	263.10	9.26	26	97987	329726	90200708
Anaphylactic reaction	224.01	9.26	366	97647	87158	90443276
Anti-cyclic citrullinated peptide antibody positive	223.83	9.26	7	98006	236426	90294008
Contraindicated product administered	218.23	9.26	41	97972	320098	90210336
Pericarditis	216.25	9.26	21	97992	270130	90260304
Hypotension	209.10	9.26	799	97214	324598	90205836
Toxic anterior segment syndrome	205.39	9.26	81	97932	2169	90528265
Duodenal ulcer perforation	204.41	9.26	8	98005	221280	90309154
Cardiac arrest	204.09	9.26	389	97624	104546	90425888
Anaphylactic shock	203.70	9.26	209	97804	31408	90499026
Joint swelling	200.48	9.26	151	97862	503149	90027285
Hepatic enzyme increased	198.68	9.26	71	97942	360665	90169769
Chronic sinusitis	195.94	9.26	180	97833	23622	90506812
Sedation complication	185.88	9.26	151	97862	16793	90513641
Arthropathy	180.77	9.26	85	97928	366157	90164277
Paraesthesia oral	175.13	9.26	193	97820	31466	90498968
Folliculitis	171.39	9.26	13	98000	204340	90326094
Helicobacter infection	168.14	9.26	23	97990	226827	90303607
Wound	162.81	9.26	62	97951	302918	90227516
Kounis syndrome	159.09	9.26	70	97943	2483	90527951
Creatinine renal clearance decreased	153.77	9.26	142	97871	18757	90511677
Rheumatoid factor positive	152.64	9.26	8	98005	171642	90358792
Procedural pain	151.97	9.26	184	97829	33176	90497258
Drug intolerance	144.17	9.26	163	97850	447428	90083006
Vaginal flatulence	143.66	9.26	115	97898	12523	90517911
Constipation	138.13	9.26	635	97378	279760	90250674
Muscle injury	138.04	9.26	15	97998	176639	90353795
Liver injury	137.13	9.26	13	98000	170554	90359880
Rheumatic fever	136.58	9.26	7	98006	153114	90377320
Therapeutic product effect decreased	136.02	9.26	65	97948	277506	90252928
Methaemoglobinaemia	134.56	9.26	72	97941	3943	90526491
Impaired healing	134.26	9.26	43	97970	234156	90296278
General physical health deterioration	131.96	9.26	114	97899	355001	90175433
Female genital tract fistula	131.50	9.26	127	97886	17741	90512693
Radiculopathy	129.60	9.26	128	97885	18377	90512057
Infusion site pain	128.08	9.26	131	97882	19607	90510827
Psoriatic arthropathy	125.54	9.26	45	97968	228290	90302144
Proctitis	124.82	9.26	115	97898	15144	90515290
Abdominal discomfort	120.55	9.26	207	97806	477121	90053313
Alopecia	118.48	9.26	222	97791	494849	90035585
Type 2 diabetes mellitus	117.05	9.26	37	97976	203207	90327227
Hypertrichosis	116.88	9.26	48	97965	1431	90529003
Depressed level of consciousness	115.47	9.26	248	97765	72536	90457898
Blood calcium decreased	114.54	9.26	152	97861	30030	90500404
Vaginal discharge	113.47	9.26	122	97891	19342	90511092
Infusion site swelling	111.08	9.26	96	97917	11624	90518810
Sleep disorder due to general medical condition, insomnia type	108.42	9.26	8	98005	128686	90401748
Generalised tonic-clonic seizure	107.46	9.26	159	97854	34744	90495690
Toxicity to various agents	106.09	9.26	601	97412	287245	90243189
Swelling	105.54	9.26	182	97831	418876	90111558
Anaesthetic complication	105.16	9.26	52	97961	2413	90528021
Irritable bowel syndrome	102.49	9.26	48	97965	207400	90323034
Insurance issue	100.32	9.26	88	97925	10870	90519564
Infusion site erythema	96.55	9.26	95	97918	13575	90516859
Stress cardiomyopathy	96.54	9.26	94	97919	13261	90517173
Infusion site extravasation	94.67	9.26	83	97930	10245	90520189
Ill-defined disorder	94.12	9.26	41	97972	184850	90345584
Swollen joint count increased	93.43	9.26	7	98006	111199	90419235
Orthostatic hypotension	89.97	9.26	162	97851	41665	90488769
C-reactive protein abnormal	89.62	9.26	15	97998	127414	90403020
Urinary tract infection	89.24	9.26	601	97412	305031	90225403
Sedation	86.81	9.26	173	97840	47998	90482436
Blister	85.17	9.26	90	97923	254908	90275526
Oral candidiasis	84.94	9.26	144	97869	35311	90495123
Sinusitis	84.74	9.26	648	97365	342440	90187994
Pulseless electrical activity	84.32	9.26	73	97940	8859	90521575
Infusion site pruritus	84.31	9.26	65	97948	6700	90523734
Hypersensitivity	84.30	9.26	234	97779	454443	90075991
Rheumatoid arthritis	83.72	9.26	166	97847	362448	90167986
Bradycardia	83.42	9.26	239	97774	83608	90446826
Dermatitis contact	82.40	9.26	87	97926	13508	90516926
Lip dry	75.33	9.26	10	98003	100945	90429489
Inflammation	73.01	9.26	52	97961	178540	90351894
Treatment failure	72.87	9.26	136	97877	303792	90226642
Blood cholesterol increased	72.20	9.26	71	97942	207941	90322493
Peripheral venous disease	71.30	9.26	5	98008	83916	90446518
Musculoskeletal stiffness	70.82	9.26	133	97880	296399	90234035
Infusion site bruising	70.31	9.26	49	97964	4323	90526111
Infusion site haemorrhage	69.65	9.26	53	97960	5358	90525076
Corneal oedema	69.12	9.26	36	97977	1865	90528569
Bursitis	68.91	9.26	28	97985	131626	90398808
Illness	68.71	9.26	220	97793	81749	90448685
Completed suicide	67.96	9.26	36	97977	145022	90385412
Stomatitis	66.66	9.26	122	97891	274576	90255858
Lower respiratory tract infection	66.64	9.26	105	97908	250554	90279880
Gait inability	66.22	9.26	38	97975	146418	90384016
Procedural hypotension	66.03	9.26	33	97980	1567	90528867
Erythema	65.79	9.26	449	97564	228797	90301637
Colitis	65.38	9.26	195	97818	69747	90460687
Creatinine renal clearance increased	65.35	9.26	42	97971	3239	90527195
Seizure	63.81	9.26	330	97683	152299	90378135
Cognitive disorder	63.45	9.26	192	97821	69215	90461219
COVID-19	63.10	9.26	354	97659	168489	90361945
Product dose omission issue	62.79	9.26	534	97479	291153	90239281
Sleep disorder	62.70	9.26	73	97940	197957	90332477
Incorrect drug administration rate	60.37	9.26	48	97965	5175	90525259
Anaesthetic complication neurological	58.39	9.26	24	97989	717	90529717
Headache	58.03	9.26	1279	96734	861467	89668967
Obesity	57.60	9.26	21	97992	105486	90424948
Fibromyalgia	57.13	9.26	84	97929	206185	90324249
Grip strength decreased	56.68	9.26	15	97998	92561	90437873
Renal function test abnormal	56.50	9.26	53	97960	7138	90523296
Pulse absent	56.18	9.26	49	97964	6006	90524428
Sulphaemoglobinaemia	55.08	9.26	21	97992	512	90529922
Emotional distress	53.69	9.26	121	97892	36541	90493893
Drug hypersensitivity	53.39	9.26	289	97724	463320	90067114
Abdominal pain upper	53.23	9.26	183	97830	332491	90197943
Discomfort	53.19	9.26	138	97875	274197	90256237
Product use issue	53.12	9.26	181	97832	329738	90200696
Extradural haematoma	52.74	9.26	31	97982	2037	90528397
Confusional state	52.45	9.26	227	97786	385978	90144456
Systemic toxicity	52.02	9.26	17	97996	259	90530175
Liver disorder	51.30	9.26	34	97979	121235	90409199
Condition aggravated	50.55	9.26	407	97606	595138	89935296
Deep vein thrombosis postoperative	50.53	9.26	8	98005	70801	90459633
Drug ineffective for unapproved indication	48.86	9.26	171	97842	66473	90463961
Product adhesion issue	48.49	9.26	42	97971	5100	90525334
Arthralgia	48.43	9.26	574	97439	777948	89752486
Apnoea	47.97	9.26	55	97958	9359	90521075
Unresponsive to stimuli	47.35	9.26	118	97895	38003	90492431
Infusion site urticaria	47.17	9.26	27	97986	1688	90528746
Pulmonary fibrosis	47.03	9.26	29	97984	107474	90422960
Adjustment disorder with depressed mood	46.47	9.26	4	98009	56749	90473685
Seasonal allergy	45.62	9.26	86	97927	22897	90507537
Extradural abscess	45.44	9.26	24	97989	1280	90529154
Upper respiratory tract infection	45.28	9.26	265	97748	128053	90402381
Anterior chamber cell	45.28	9.26	20	97993	716	90529718
Balance disorder	44.88	9.26	216	97797	96864	90433570
Ventricular fibrillation	44.70	9.26	65	97948	13979	90516455
Prescribed overdose	44.60	9.26	25	97988	97600	90432834
Joint range of motion decreased	44.01	9.26	49	97964	135594	90394840
Haematochezia	43.66	9.26	172	97841	70741	90459693
C-reactive protein increased	43.59	9.26	81	97932	181308	90349126
Staphylococcal infection	43.34	9.26	133	97880	48306	90482128
Inappropriate schedule of product administration	43.19	9.26	294	97719	149639	90380795
Fear	43.15	9.26	70	97943	16552	90513882
Rectal haemorrhage	42.60	9.26	190	97823	82554	90447880
Prescribed underdose	42.56	9.26	14	97999	75005	90455429
Musculoskeletal pain	42.47	9.26	75	97938	171176	90359258
Ventricular tachycardia	41.26	9.26	86	97927	24622	90505812
Peripheral swelling	40.95	9.26	270	97743	412836	90117598
Mental status changes	40.27	9.26	123	97890	44556	90485878
Product formulation issue	40.22	9.26	18	97995	665	90529769
Hip arthroplasty	40.21	9.26	16	97997	76192	90454242
Lagophthalmos	39.63	9.26	16	97997	456	90529978
Lung disorder	39.61	9.26	63	97950	149820	90380614
Bronchitis	39.46	9.26	292	97721	152635	90377799
Wheezing	39.41	9.26	129	97884	237951	90292483
Hypercholesterolaemia	39.13	9.26	31	97982	100861	90429573
Night sweats	39.12	9.26	49	97964	128717	90401717
Peripheral nerve injury	38.86	9.26	18	97995	721	90529713
Infusion site mass	38.68	9.26	26	97987	2163	90528271
Knee arthroplasty	38.43	9.26	21	97992	83161	90447273
Hypopyon	38.16	9.26	19	97994	895	90529539
Blepharospasm	37.94	9.26	7	98006	55438	90474996
Respiratory tract infection	37.76	9.26	145	97868	58933	90471501
Tachycardia	37.30	9.26	295	97718	157378	90373056
Bursitis infective	36.85	9.26	22	97991	1488	90528946
Administration site pain	36.17	9.26	20	97993	1169	90529265
Wound infection	36.12	9.26	37	97976	106365	90424069
Endophthalmitis	35.80	9.26	34	97979	4651	90525783
Localised infection	35.65	9.26	98	97915	33464	90496970
Nail disorder	35.35	9.26	10	98003	59057	90471377
Type I hypersensitivity	35.32	9.26	32	97981	4123	90526311
Spinal epidural haemorrhage	35.26	9.26	13	98000	288	90530146
Embolia cutis medicamentosa	34.87	9.26	16	97997	627	90529807
Spinal epidural haematoma	34.03	9.26	20	97993	1314	90529120
Osteoarthritis	33.83	9.26	104	97909	195626	90334808
Bone erosion	33.60	9.26	8	98005	53013	90477421
Frequent bowel movements	33.37	9.26	136	97877	56799	90473635
Rash	33.22	9.26	634	97379	795466	89734968
Status epilepticus	33.06	9.26	67	97946	18807	90511627
Gastrointestinal disorder	32.94	9.26	154	97859	256533	90273901
Pneumocephalus	32.93	9.26	12	98001	257	90530177
Multiple drug therapy	32.47	9.26	39	97974	6970	90523464
Corneal epithelium defect	32.34	9.26	14	97999	477	90529957
Bronchospasm	32.18	9.26	70	97943	20639	90509795
Unevaluable event	32.14	9.26	131	97882	54717	90475717
Kidney infection	31.95	9.26	80	97933	25836	90504598
Bundle branch block left	31.91	9.26	41	97972	7844	90522590
Chills	31.80	9.26	248	97765	131733	90398701
Weight increased	31.67	9.26	294	97719	417633	90112801
Infusion site discharge	31.67	9.26	24	97989	2411	90528023
Dry mouth	31.66	9.26	98	97915	183961	90346473
Nausea	31.03	9.26	1482	96531	1108834	89421600
Sinus tachycardia	31.03	9.26	84	97929	28429	90502005
Colitis ulcerative	30.73	9.26	138	97875	60128	90470306
Renal injury	30.58	9.26	46	97967	10197	90520237
Autoimmune disorder	30.50	9.26	23	97990	76721	90453713
Haemorrhoids	30.41	9.26	80	97933	26622	90503812
Lupus vulgaris	30.17	9.26	6	98007	45053	90485381
Drug-induced liver injury	29.99	9.26	32	97981	90286	90440148
Stridor	29.63	9.26	31	97982	4762	90525672
Vascular malformation	29.54	9.26	15	97998	737	90529697
Adverse event	29.49	9.26	51	97962	117367	90413067
Anhedonia	29.48	9.26	48	97965	11383	90519051
Loss of personal independence in daily activities	29.10	9.26	65	97948	136040	90394394
Infusion site rash	29.08	9.26	23	97990	2460	90527974
Ophthalmoplegia	29.06	9.26	20	97993	1729	90528705
Red blood cell sedimentation rate increased	28.86	9.26	28	97985	82567	90447867
Paranasal cyst	28.48	9.26	15	97998	795	90529639
Cauda equina syndrome	28.47	9.26	18	97995	1349	90529085
Paraplegia	28.46	9.26	26	97987	3386	90527048
Meningitis chemical	28.34	9.26	11	98002	282	90530152
Neurotoxicity	28.30	9.26	68	97945	21399	90509035
Vitritis	28.11	9.26	19	97994	1595	90528839
Premature delivery	28.01	9.26	99	97914	38663	90491771
Anal skin tags	27.99	9.26	14	97999	666	90529768
Hepatic cirrhosis	27.75	9.26	17	97996	63236	90467198
Parophthalmia	27.66	9.26	12	98001	411	90530023
Epidural haemorrhage	27.60	9.26	11	98002	303	90530131
Back pain	27.52	9.26	489	97524	316686	90213748
Fear of eating	27.42	9.26	12	98001	420	90530014
Purtscher retinopathy	27.31	9.26	9	98004	141	90530293
Onychomadesis	27.14	9.26	8	98005	45990	90484444
Tenderness	27.11	9.26	77	97936	26791	90503643
Hepatitis	27.10	9.26	22	97991	70717	90459717
Infusion site nodule	26.98	9.26	19	97994	1704	90528730
Respiratory depression	26.94	9.26	55	97958	15520	90514914
Eye pain	26.28	9.26	106	97907	44062	90486372
Skin infection	26.20	9.26	59	97954	17805	90512629
Stress	26.10	9.26	164	97849	81231	90449203
Ear infection	25.85	9.26	146	97867	69629	90460805
Cellulitis	25.64	9.26	178	97835	91159	90439275
Myelosuppression	25.54	9.26	13	98000	53578	90476856
Platelet aggregation inhibition	25.27	9.26	9	98004	180	90530254
Hypoxia	25.19	9.26	149	97864	72250	90458184
Skin warm	25.08	9.26	36	97977	7651	90522783
Aqueous fibrin	24.91	9.26	8	98005	115	90530319
Eyelid ptosis	24.85	9.26	39	97974	8967	90521467
Eye irritation	24.74	9.26	87	97926	33891	90496543
Administration site swelling	24.57	9.26	17	97996	1482	90528952
Photophobia	24.50	9.26	64	97949	21205	90509229
Psoriasis	24.48	9.26	80	97933	147674	90382760
Multiple allergies	24.46	9.26	52	97961	15094	90515340
Underdose	24.43	9.26	14	97999	54003	90476431
Product use in unapproved indication	24.26	9.26	504	97509	335732	90194702
Septic arthritis staphylococcal	24.10	9.26	12	98001	565	90529869
Retinitis	23.98	9.26	6	98007	38452	90491982
Spinal cord compression	23.86	9.26	28	97985	4883	90525551
Medical device site cellulitis	23.70	9.26	9	98004	217	90530217
Product preparation error	23.68	9.26	41	97972	10220	90520214
Trigeminal palsy	23.67	9.26	7	98006	75	90530359
Vitamin D increased	23.65	9.26	14	97999	932	90529502
Visual acuity reduced	23.53	9.26	67	97946	23343	90507091
Foreign body sensation in eyes	23.43	9.26	23	97990	3277	90527157
Body tinea	23.25	9.26	19	97994	2129	90528305
Diplopia	23.09	9.26	76	97937	28638	90501796
Otitis media	22.94	9.26	30	97983	5840	90524594
Post procedural complication	22.66	9.26	58	97955	18984	90511450
Epidural analgesia	22.32	9.26	8	98005	163	90530271
Lower limb fracture	22.20	9.26	36	97977	84977	90445457
Procedure aborted	22.10	9.26	8	98005	168	90530266
Therapy partial responder	22.07	9.26	63	97950	21980	90508454
Weight decreased	21.96	9.26	552	97461	379358	90151076
Retinal vasculitis	21.86	9.26	16	97997	1525	90528909
Infusion site discomfort	21.66	9.26	17	97996	1799	90528635
Ejection fraction decreased	21.57	9.26	70	97943	26183	90504251
C-reactive protein	21.38	9.26	4	98009	31363	90499071
Foetal heart rate abnormal	20.87	9.26	13	98000	949	90529485
Superinfection	20.82	9.26	21	97992	3091	90527343
Mastoiditis	20.71	9.26	16	97997	1654	90528780
Medical device site abscess	20.69	9.26	8	98005	203	90530231
Gastroenteritis viral	20.64	9.26	76	97937	30279	90500155
Punctate keratitis	20.48	9.26	12	98001	784	90529650
Retinal artery occlusion	20.31	9.26	18	97995	2253	90528181
Liver function test increased	20.28	9.26	38	97975	84817	90445617
Upper airway obstruction	20.03	9.26	13	98000	1019	90529415
Neuromuscular block prolonged	19.93	9.26	11	98002	641	90529793
Procedural complication	19.87	9.26	28	97985	5850	90524584
Infection	19.82	9.26	274	97739	361820	90168614
Back injury	19.81	9.26	13	98000	46609	90483825
Overdose	19.80	9.26	259	97754	157450	90372984
Nerve root injury	19.75	9.26	6	98007	71	90530363
Poor venous access	19.74	9.26	56	97957	19471	90510963
Sciatica	19.63	9.26	51	97962	101331	90429103
Memory impairment	19.47	9.26	129	97884	197115	90333319
Intentional self-injury	19.45	9.26	4	98009	29330	90501104
Proctalgia	19.24	9.26	33	97980	8165	90522269
Foetal exposure during delivery	19.19	9.26	9	98004	371	90530063
Hepatotoxicity	19.18	9.26	13	98000	45829	90484605
Atonic urinary bladder	19.16	9.26	7	98006	151	90530283
Infusion site warmth	18.96	9.26	17	97996	2161	90528273
Ventricular hypokinesia	18.89	9.26	26	97987	5315	90525119
Spinal anaesthesia	18.83	9.26	6	98007	84	90530350
Transferrin decreased	18.79	9.26	9	98004	389	90530045
Airway peak pressure increased	18.37	9.26	9	98004	409	90530025
Nephrolithiasis	18.37	9.26	103	97910	48982	90481452
Arthritis	18.29	9.26	106	97907	167209	90363225
Coeliac disease	18.20	9.26	13	98000	44597	90485837
Incorrect route of product administration	18.14	9.26	105	97908	50521	90479913
Cardiogenic shock	18.12	9.26	63	97950	24405	90506029
Abortion spontaneous	18.11	9.26	19	97994	54037	90476397
Injection site alopecia	18.00	9.26	5	98008	42	90530392
Product distribution issue	17.80	9.26	21	97992	3684	90526750
Viral infection	17.61	9.26	90	97923	41324	90489110
Thyroid atrophy	17.57	9.26	8	98005	308	90530126
Arthritis bacterial	17.51	9.26	30	97983	7415	90523019
Ventricular extrasystoles	17.50	9.26	42	97971	13208	90517226
Hyperthermia malignant	17.34	9.26	13	98000	1285	90529149
Road traffic accident	17.32	9.26	59	97954	107567	90422867
Vision blurred	17.30	9.26	189	97824	110104	90420330
Nerve block	17.05	9.26	11	98002	854	90529580
Vasoplegia syndrome	17.04	9.26	18	97995	2796	90527638
Infusion site discolouration	17.03	9.26	12	98001	1077	90529357
Thrombocytopenia	17.03	9.26	144	97869	208581	90321853
Hypoaesthesia oral	17.02	9.26	46	97967	15554	90514880
Suicide attempt	16.95	9.26	35	97978	75364	90455070
Apnoeic attack	16.94	9.26	8	98005	335	90530099
Meningitis aseptic	16.87	9.26	28	97985	6745	90523689
Nystagmus	16.84	9.26	29	97984	7198	90523236
Circulatory collapse	16.63	9.26	62	97951	24842	90505592
Vocal cord dysfunction	16.49	9.26	11	98002	903	90529531
Onychomycosis	16.46	9.26	10	98003	37366	90493068
Economic problem	16.43	9.26	19	97994	3262	90527172
Monoplegia	16.30	9.26	20	97993	3654	90526780
Vascular stenosis	16.26	9.26	9	98004	527	90529907
Fall	16.23	9.26	656	97357	481154	90049280
Nail bed tenderness	16.20	9.26	8	98005	370	90530064
Heliotrope rash	16.18	9.26	7	98006	238	90530196
Taste disorder	16.13	9.26	26	97987	61520	90468914
Dysphoria	16.09	9.26	26	97987	6128	90524306
Depression	15.90	9.26	229	97784	300372	90230062
Anxiety	15.85	9.26	443	97570	309329	90221105
Loss of consciousness	15.84	9.26	226	97787	140012	90390422
Tinnitus	15.84	9.26	90	97923	43012	90487422
Paralysis	15.83	9.26	37	97976	11441	90518993
Drug interaction	15.76	9.26	401	97612	276052	90254382
Pulmonary oedema	15.70	9.26	118	97895	61962	90468472
Leukopenia	15.68	9.26	56	97957	100654	90429780
Eye infarction	15.50	9.26	5	98008	73	90530361
Cardio-respiratory arrest	15.40	9.26	119	97894	63021	90467413
Drug ineffective	15.39	9.26	1715	96298	1382583	89147851
Spinal synovial cyst	15.31	9.26	5	98008	76	90530358
Haemodynamic instability	15.28	9.26	37	97976	11702	90518732
Obstruction	15.26	9.26	20	97993	3901	90526533
Left ventricle outflow tract obstruction	15.19	9.26	8	98005	424	90530010
Anaphylactoid shock	15.09	9.26	8	98005	430	90530004
Inadequate analgesia	15.03	9.26	18	97995	3206	90527228
Drug tolerance decreased	15.00	9.26	8	98005	32122	90498312
Pancreatitis acute	14.99	9.26	8	98005	32107	90498327
Walking aid user	14.95	9.26	10	98003	35496	90494938
Mouth swelling	14.91	9.26	24	97989	5638	90524796
Hypertensive emergency	14.90	9.26	15	97998	2202	90528232
Electrocardiogram ST segment elevation	14.89	9.26	20	97993	3996	90526438
Product administration interrupted	14.81	9.26	38	97975	12454	90517980
Respiratory distress	14.76	9.26	82	97931	38864	90491570
Iron binding capacity total decreased	14.62	9.26	8	98005	458	90529976
Maternal exposure during pregnancy	14.58	9.26	288	97725	359775	90170659
Pain	14.50	9.26	1258	96755	995083	89535351
Scleral hyperaemia	14.48	9.26	7	98006	309	90530125
Poikiloderma	14.44	9.26	7	98006	311	90530123
Wrong product administered	14.37	9.26	28	97985	7637	90522797
Gastrooesophageal reflux disease	14.37	9.26	113	97900	166224	90364210
Oral herpes	14.35	9.26	73	97940	33451	90496983
Intercepted medication error	14.30	9.26	10	98003	887	90529547
Cough	14.24	9.26	510	97503	368452	90161982
Impaired quality of life	14.13	9.26	56	97957	23088	90507346
Retinal detachment	14.13	9.26	26	97987	6796	90523638
Allergy to immunoglobulin therapy	14.07	9.26	6	98007	197	90530237
Streptococcal infection	14.01	9.26	27	97986	7306	90523128
Foot deformity	14.00	9.26	27	97986	59624	90470810
Blood pressure decreased	13.97	9.26	133	97880	74762	90455672
Anal sphincter atony	13.93	9.26	7	98006	336	90530098
Eyelid contusion	13.90	9.26	5	98008	103	90530331
Product administration error	13.84	9.26	61	97952	26362	90504072
Apgar score low	13.78	9.26	11	98002	1192	90529242
Brain stem syndrome	13.76	9.26	9	98004	715	90529719
Infection susceptibility increased	13.72	9.26	19	97994	3907	90526527
Anaemia	13.69	9.26	488	97525	352314	90178120
Inhibitory drug interaction	13.68	9.26	17	97996	3146	90527288
Conjunctival oedema	13.61	9.26	10	98003	959	90529475
Glucose tolerance impaired	13.57	9.26	28	97985	7957	90522477
Administration site extravasation	13.57	9.26	11	98002	1219	90529215
Arthritis infective	13.56	9.26	28	97985	7964	90522470
Orbital infection	13.51	9.26	5	98008	112	90530322
Vaginal abscess	13.50	9.26	8	98005	534	90529900
Cerebral congestion	13.43	9.26	5	98008	114	90530320
Exostosis	13.41	9.26	23	97990	53111	90477323
Lupus-like syndrome	13.41	9.26	20	97993	48826	90481608
Foetal death	13.38	9.26	3	98010	20720	90509714
Heparin-induced thrombocytopenia	13.29	9.26	22	97991	5290	90525144
Mydriasis	13.22	9.26	41	97972	14971	90515463
Cystitis	13.21	9.26	120	97893	66598	90463836
Blood pressure abnormal	13.20	9.26	49	97964	19596	90510838
Quadriparesis	13.17	9.26	15	97998	2534	90527900
Neonatal toxicity	13.11	9.26	4	98009	48	90530386
Asthenia	13.11	9.26	459	97554	533292	89997142
Neuralgia	13.07	9.26	68	97945	31432	90499002
Delayed recovery from anaesthesia	13.06	9.26	10	98003	1020	90529414
Axillary nerve injury	13.04	9.26	4	98009	49	90530385
Influenza like illness	13.04	9.26	139	97874	80472	90449962
Labelled drug-drug interaction medication error	13.00	9.26	40	97973	14542	90515892
Infusion site streaking	12.91	9.26	8	98005	579	90529855
Liver function test abnormal	12.84	9.26	22	97991	50823	90479611
Skin discolouration	12.81	9.26	87	97926	44228	90486206
Sinusitis bacterial	12.79	9.26	13	98000	1930	90528504
Anterior chamber fibrin	12.78	9.26	5	98008	131	90530303
Body dysmorphic disorder	12.74	9.26	7	98006	404	90530030
Lethargy	12.72	9.26	114	97899	63025	90467409
Peripheral vascular disorder	12.68	9.26	24	97989	6407	90524027
Infusion site scar	12.67	9.26	8	98005	598	90529836
Anorectal discomfort	12.63	9.26	16	97997	3018	90527416
Laboratory test abnormal	12.63	9.26	16	97997	41838	90488596
Epilepsy	12.60	9.26	46	97967	82160	90448274
Immunodeficiency	12.56	9.26	17	97996	43217	90487217
Vascular resistance systemic decreased	12.54	9.26	5	98008	138	90530296
Injection site atrophy	12.51	9.26	9	98004	835	90529599
Implant site bruising	12.51	9.26	7	98006	419	90530015
Calcinosis	12.49	9.26	15	97998	2680	90527754
Fibula agenesis	12.49	9.26	4	98009	57	90530377
Ocular hypertension	12.47	9.26	12	98001	1668	90528766
Nasopharyngitis	12.45	9.26	340	97673	406764	90123670
Abdominal pain	12.45	9.26	535	97478	395186	90135248
Post procedural infection	12.43	9.26	33	97980	11041	90519393
Spina bifida occulta	12.42	9.26	4	98009	58	90530376
Hepatocellular injury	12.40	9.26	8	98005	28950	90501484
Procedural anxiety	12.40	9.26	9	98004	847	90529587
Duodenal stenosis	12.39	9.26	8	98005	622	90529812
Spinal stroke	12.24	9.26	4	98009	61	90530373
Intraocular pressure increased	12.21	9.26	25	97988	7068	90523366
Akinesia	12.14	9.26	12	98001	1724	90528710
Aphonia	12.13	9.26	35	97978	12284	90518150
Gastric mucosa erythema	12.09	9.26	7	98006	447	90529987
Physical disability	12.06	9.26	18	97995	3963	90526471
Skin test positive	11.99	9.26	9	98004	891	90529543
Administration site erythema	11.91	9.26	9	98004	900	90529534
Cancer pain	11.91	9.26	18	97995	4007	90526427
Arthritis fungal	11.89	9.26	4	98009	67	90530367
Infusion site oedema	11.86	9.26	10	98003	1171	90529263
Anaphylactoid reaction	11.85	9.26	19	97994	4449	90525985
Macular oedema	11.84	9.26	20	97993	4889	90525545
Tremor	11.82	9.26	232	97781	152941	90377493
Nail bed inflammation	11.77	9.26	12	98001	1789	90528645
Instillation site pain	11.73	9.26	9	98004	921	90529513
Amnesia	11.72	9.26	69	97944	108436	90421998
Pustule	11.68	9.26	15	97998	2868	90527566
Finger deformity	11.67	9.26	11	98002	32886	90497548
Swelling face	11.67	9.26	137	97876	81215	90449219
Hypoaesthesia	11.63	9.26	255	97758	313955	90216479
Electrocardiogram QRS complex prolonged	11.60	9.26	25	97988	7323	90523111
Intraocular pressure fluctuation	11.57	9.26	4	98009	73	90530361
Eclampsia	11.49	9.26	7	98006	491	90529943
Product administered at inappropriate site	11.49	9.26	18	97995	4133	90526301
Trigemino-cardiac reflex	11.47	9.26	4	98009	75	90530359
Agitation	11.47	9.26	117	97896	66981	90463453
Bacterial infection	11.44	9.26	53	97960	23391	90507043
Dermatitis	11.41	9.26	51	97962	22169	90508265
Dermatitis atopic	11.40	9.26	53	97960	23419	90507015
Insomnia	11.40	9.26	274	97739	333200	90197234
Neutropenia	11.31	9.26	173	97840	224731	90305703
Quadriplegia	11.31	9.26	13	98000	2218	90528216
Papule	11.26	9.26	26	97987	7976	90522458
Sensory loss	11.25	9.26	44	97969	18031	90512403
Cholestasis of pregnancy	11.21	9.26	11	98002	1566	90528868
Oral pain	11.20	9.26	67	97946	32616	90497818
Intentional product use issue	11.20	9.26	166	97847	216726	90313708
Fear-related avoidance of activities	11.14	9.26	5	98008	186	90530248
Seronegative arthritis	11.07	9.26	3	98010	18231	90512203
Appetite disorder	11.05	9.26	28	97985	9105	90521329
Venous injury	11.05	9.26	8	98005	750	90529684
Drug resistance	11.02	9.26	10	98003	30439	90499995
Pneumonia mycoplasmal	10.98	9.26	9	98004	1013	90529421
Device expulsion	10.97	9.26	17	97996	40869	90489565
Phrenic nerve paralysis	10.96	9.26	6	98007	344	90530090
Corneal abrasion	10.92	9.26	10	98003	1306	90529128
Haematocrit increased	10.91	9.26	15	97998	3063	90527371
Orbital oedema	10.89	9.26	6	98007	348	90530086
Accelerated idioventricular rhythm	10.88	9.26	4	98009	88	90530346
Allergy to metals	10.84	9.26	9	98004	1031	90529403
Metapneumovirus infection	10.80	9.26	10	98003	1325	90529109
Haemangioma congenital	10.78	9.26	7	98006	549	90529885
Pseudomonas infection	10.77	9.26	38	97975	14827	90515607
Ischaemia	10.74	9.26	20	97993	5275	90525159
Infusion site injury	10.71	9.26	4	98009	92	90530342
Infusion site irritation	10.68	9.26	10	98003	1343	90529091
Tryptase increased	10.66	9.26	7	98006	560	90529874
Application site alopecia	10.61	9.26	3	98010	27	90530407
Implant site swelling	10.60	9.26	7	98006	565	90529869
Genital ulceration	10.60	9.26	9	98004	1064	90529370
Dysuria	10.59	9.26	76	97937	39325	90491109
Vanishing bile duct syndrome	10.56	9.26	10	98003	1362	90529072
Repetitive strain injury	10.53	9.26	5	98008	212	90530222
Retinal cyst	10.51	9.26	4	98009	97	90530337
Mean arterial pressure decreased	10.51	9.26	5	98008	213	90530221
Inappropriate antidiuretic hormone secretion	10.45	9.26	4	98009	19501	90510933
Off label use	10.41	9.26	1352	96661	1100900	89429534
Respiratory failure	10.40	9.26	183	97830	118235	90412199
Ocular procedural complication	10.37	9.26	6	98007	383	90530051
Drug reaction with eosinophilia and systemic symptoms	10.35	9.26	19	97994	42739	90487695
Spinal cord injury	10.34	9.26	9	98004	1100	90529334
Conduction disorder	10.33	9.26	11	98002	1724	90528710
Glomerulonephritis acute	10.29	9.26	4	98009	103	90530331
Rectosigmoid cancer metastatic	10.24	9.26	3	98010	31	90530403
Laryngitis	10.23	9.26	25	97988	50728	90479706
Autonomic neuropathy	10.23	9.26	10	98003	1417	90529017
Haemorrhagic vasculitis	10.22	9.26	4	98009	105	90530329
Allergic cough	10.21	9.26	9	98004	1119	90529315
Injury	10.20	9.26	151	97862	197198	90333236
Normal newborn	10.09	9.26	51	97962	23311	90507123
Coccygectomy	10.07	9.26	3	98010	33	90530401
Sympathectomy	10.07	9.26	3	98010	33	90530401
Speech disorder	10.07	9.26	84	97929	45501	90484933
Acute respiratory failure	9.97	9.26	80	97933	42838	90487596
Diplegia	9.95	9.26	10	98003	1465	90528969
Product contamination	9.83	9.26	9	98004	1175	90529259
Limb injury	9.80	9.26	63	97950	31445	90498989
Nasal mucosal disorder	9.72	9.26	11	98002	1846	90528588
Infusion related hypersensitivity reaction	9.68	9.26	7	98006	655	90529779
Hallucination, tactile	9.66	9.26	6	98007	436	90529998
Infusion related reaction	9.64	9.26	361	97652	416419	90114015
Incision site rash	9.62	9.26	3	98010	39	90530395
Supraventricular extrasystoles	9.61	9.26	19	97994	5238	90525196
Central pain syndrome	9.60	9.26	7	98006	663	90529771
Device ineffective	9.60	9.26	5	98008	259	90530175
Death of relative	9.58	9.26	6	98007	442	90529992
Tumour pain	9.57	9.26	11	98002	1876	90528558
Retinal haemorrhage	9.55	9.26	20	97993	5744	90524690
Pancreatitis	9.48	9.26	41	97972	69785	90460649
Device infusion issue	9.48	9.26	13	98000	2649	90527785
Oropharyngeal pain	9.41	9.26	176	97837	115011	90415423
Hordeolum	9.37	9.26	18	97995	4860	90525574
Septic shock	9.37	9.26	53	97960	84107	90446327
Poor quality sleep	9.36	9.26	52	97961	24641	90505793
Anorgasmia	9.33	9.26	7	98006	693	90529741
Joint stiffness	9.32	9.26	48	97965	77994	90452440
Ocular discomfort	9.30	9.26	21	97992	6349	90524085
Renal cyst	9.29	9.26	33	97980	12917	90517517
Immobilisation syndrome	9.28	9.26	6	98007	467	90529967

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	489.81	10.60	163	55999	2137	42563036
Anaphylactic shock	198.60	10.60	197	55965	23320	42541853
Methaemoglobinaemia	191.54	10.60	110	56052	5664	42559509
Anaphylactic reaction	183.75	10.60	253	55909	42490	42522683
Inspiratory capacity decreased	159.43	10.60	78	56084	2889	42562284
Hypertrichosis	145.96	10.60	47	56115	551	42564622
Product formulation issue	132.49	10.60	47	56115	754	42564419
Anaesthetic complication	114.93	10.60	50	56112	1407	42563766
Cardiac arrest	114.21	10.60	360	55802	108960	42456213
Fear	98.42	10.60	95	56067	10870	42554303
Toxic anterior segment syndrome	96.94	10.60	44	56118	1372	42563801
Hypotension	93.62	10.60	620	55542	257011	42308162
Injury	91.24	10.60	129	56033	22187	42542986
Emotional distress	85.84	10.60	106	56056	15987	42549186
Toxicity to various agents	80.52	10.60	547	55615	228589	42336584
Ventricular tachycardia	78.66	10.60	142	56020	30018	42535155
Anhedonia	73.91	10.60	69	56093	7571	42557602
Bradycardia	69.48	10.60	259	55903	85225	42479948
Renal injury	64.07	10.60	80	56082	12200	42552973
Ventricular fibrillation	63.99	10.60	130	56032	29993	42535180
Generalised tonic-clonic seizure	63.51	10.60	120	56042	26259	42538914
Electrocardiogram ST segment elevation	58.15	10.60	54	56108	5885	42559288
Ocular procedural complication	54.30	10.60	13	56149	43	42565130
Tachycardia	54.14	10.60	270	55892	100817	42464356
Pericardial effusion	52.56	10.60	118	56044	29157	42536016
Drug ineffective	51.22	10.60	1136	55026	629061	41936112
Interstitial lung disease	47.40	10.60	22	56140	78440	42486733
Unresponsive to stimuli	46.04	10.60	117	56045	31286	42533887
Sinusitis	45.03	10.60	151	56011	47141	42518032
Overdose	43.47	10.60	262	55900	105002	42460171
Drug ineffective for unapproved indication	42.72	10.60	146	56016	46017	42519156
Incorrect route of product administration	41.45	10.60	96	56066	24209	42540964
Anal inflammation	40.35	10.60	29	56133	2200	42562973
Infusion site extravasation	39.17	10.60	42	56120	5439	42559734
Disease progression	38.80	10.60	82	56080	143574	42421599
Infusion site pain	37.96	10.60	41	56121	5354	42559819
Adulterated product	37.78	10.60	19	56143	747	42564426
Spinal cord infarction	37.26	10.60	18	56144	648	42564525
Accident	36.57	10.60	44	56118	6459	42558714
Pain	35.98	10.60	486	55676	244362	42320811
Stress	35.93	10.60	134	56028	44078	42521095
Hyperthermia malignant	35.81	10.60	29	56133	2629	42562544
Insurance issue	35.69	10.60	35	56127	4081	42561092
SARS-CoV-2 test negative	34.22	10.60	24	56138	1751	42563422
Trigemino-cardiac reflex	33.46	10.60	14	56148	357	42564816
Unevaluable event	33.10	10.60	110	56052	34178	42530995
Accidental overdose	32.99	10.60	97	56065	28233	42536940
Diarrhoea	32.35	10.60	421	55741	460428	42104745
Proctalgia	31.98	10.60	43	56119	7050	42558123
Infusion site erythema	31.78	10.60	31	56131	3591	42561582
Ear infection	31.75	10.60	59	56103	12745	42552428
Haemorrhoids	30.78	10.60	69	56093	17028	42548145
Cauda equina syndrome	30.72	10.60	18	56144	962	42564211
Sinus tachycardia	30.32	10.60	77	56085	20576	42544597
Status epilepticus	28.19	10.60	63	56099	15515	42549658
Electrocardiogram QRS complex prolonged	27.33	10.60	36	56126	5787	42559386
Cardiogenic shock	27.29	10.60	106	56056	35534	42529639
Oculocardiac reflex	27.17	10.60	9	56153	116	42565057
Anaesthetic complication neurological	27.05	10.60	15	56147	721	42564452
Tracheitis	24.71	10.60	16	56146	1023	42564150
Product label on wrong product	24.58	10.60	7	56155	52	42565121
Blood phosphorus increased	24.19	10.60	52	56110	12473	42552700
Acute kidney injury	24.13	10.60	340	55822	366997	42198176
Haemodynamic instability	24.10	10.60	52	56110	12505	42552668
Hypoxia	24.06	10.60	166	55996	69620	42495553
Respiratory tract infection bacterial	23.98	10.60	20	56142	1889	42563284
Tubulointerstitial nephritis	23.97	10.60	6	56156	31542	42533631
Injection related reaction	23.87	10.60	13	56149	603	42564570
Negative pressure pulmonary oedema	23.69	10.60	13	56149	612	42564561
Product adhesion issue	23.48	10.60	19	56143	1720	42563453
Myelosuppression	23.44	10.60	12	56150	40449	42524724
Suicide attempt	23.42	10.60	16	56146	46084	42519089
Bronchospasm	23.19	10.60	52	56110	12833	42552340
Infusion site swelling	23.13	10.60	25	56137	3267	42561906
Cardiac tamponade	22.68	10.60	35	56127	6505	42558668
Rheumatoid arthritis	22.55	10.60	14	56148	42426	42522747
Mydriasis	22.48	10.60	41	56121	8729	42556444
Leukopenia	22.48	10.60	40	56122	74706	42490467
Blindness	22.32	10.60	63	56099	17915	42547258
Mixed anxiety and depressive disorder	21.35	10.60	9	56153	234	42564939
Laryngospasm	21.27	10.60	19	56143	1969	42563204
Neurotoxicity	21.17	10.60	74	56088	23577	42541596
Chemical burn	21.15	10.60	10	56152	343	42564830
Corneal oedema	21.09	10.60	17	56145	1531	42563642
Kounis syndrome	20.95	10.60	24	56138	3344	42561829
Apnoea	20.67	10.60	37	56125	7766	42557407
Respiratory depression	20.45	10.60	63	56099	18805	42546368
Vasoplegia syndrome	20.14	10.60	21	56141	2634	42562539
Brain stem syndrome	20.08	10.60	12	56150	665	42564508
Seizure	20.07	10.60	245	55917	120316	42444857
Brain oedema	20.06	10.60	57	56105	16270	42548903
Respiratory tract infection	19.91	10.60	78	56084	26244	42538929
Renal cyst haemorrhage	19.87	10.60	12	56150	678	42564495
Decreased appetite	19.86	10.60	161	56001	192976	42372197
Thrombocytopenia	19.85	10.60	158	56004	190121	42375052
Swelling	19.78	10.60	132	56030	54753	42510420
Cytomegalovirus infection	19.59	10.60	9	56153	32297	42532876
Neuralgia	19.40	10.60	76	56086	25571	42539602
Anxiety	19.33	10.60	240	55922	118320	42446853
Rectal prolapse	19.31	10.60	11	56151	557	42564616
Diabetes insipidus	19.06	10.60	24	56138	3689	42561484
Intracranial hypotension	18.83	10.60	10	56152	441	42564732
Postoperative delirium	18.75	10.60	11	56151	589	42564584
Lagophthalmos	18.59	10.60	7	56155	134	42565039
Hyperphosphataemia	18.59	10.60	48	56114	12956	42552217
Myasthenia gravis	18.54	10.60	55	56107	16082	42549091
Prostate cancer	18.37	10.60	19	56143	44624	42520549
Neuromuscular blockade	18.18	10.60	9	56153	342	42564831
Embolia cutis medicamentosa	18.11	10.60	9	56153	345	42564828
Type I hypersensitivity	18.01	10.60	18	56144	2148	42563025
Aqueous fibrin	18.00	10.60	6	56156	79	42565094
Drug interaction	17.91	10.60	246	55916	266753	42298420
Agranulocytosis	17.85	10.60	9	56153	30603	42534570
Retinal artery occlusion	17.67	10.60	18	56144	2197	42562976
Mental status changes	17.47	10.60	105	56057	42010	42523163
Respiratory tract infection viral	17.46	10.60	22	56140	3384	42561789
Loss of consciousness	17.29	10.60	192	55970	92162	42473011
Weight decreased	17.21	10.60	183	55979	207765	42357408
Vascular compression	17.20	10.60	9	56153	385	42564788
Seizure like phenomena	17.00	10.60	13	56149	1084	42564089
Pneumocystis jirovecii pneumonia	16.93	10.60	6	56156	25175	42539998
Dermatitis contact	16.89	10.60	25	56137	4478	42560695
Reperfusion arrhythmia	16.87	10.60	6	56156	97	42565076
Pulmonary fibrosis	16.87	10.60	7	56155	26674	42538499
Myoclonus	16.69	10.60	55	56107	17010	42548163
Vitreous floaters	16.62	10.60	24	56138	4206	42560967
Drug therapy	16.58	10.60	30	56132	6350	42558823
Macular ischaemia	16.57	10.60	7	56155	183	42564990
Appendicolith	16.56	10.60	47	56115	13409	42551764
Spinal meningeal cyst	16.54	10.60	6	56156	103	42565070
Swelling of eyelid	16.44	10.60	17	56145	2111	42563062
Infusion site bruising	16.35	10.60	12	56150	940	42564233
Electrocardiogram ST-T segment depression	16.32	10.60	4	56158	15	42565158
Circulatory collapse	16.26	10.60	68	56094	23568	42541605
Vascular anastomotic haemorrhage	16.13	10.60	8	56154	305	42564868
Analgesic therapy	16.10	10.60	30	56132	6494	42558679
Endophthalmitis	15.76	10.60	24	56138	4409	42560764
Tryptase increased	15.73	10.60	8	56154	322	42564851
Ventricular extrasystoles	15.73	10.60	46	56116	13344	42551829
Paraesthesia oral	15.67	10.60	26	56136	5137	42560036
Kidney congestion	15.65	10.60	9	56153	464	42564709
Administration site pain	15.64	10.60	9	56153	465	42564708
Oesophageal injury	15.61	10.60	7	56155	212	42564961
Post procedural complication	15.51	10.60	44	56118	12546	42552627
Respiratory acidosis	15.48	10.60	29	56133	6302	42558871
Thyrotoxic crisis	15.44	10.60	11	56151	823	42564350
Rhabdomyolysis	15.39	10.60	52	56110	77967	42487206
Corneal opacity	15.22	10.60	10	56152	655	42564518
Chorioretinopathy	15.14	10.60	14	56148	1517	42563656
Body temperature increased	15.14	10.60	60	56102	20298	42544875
General physical health deterioration	15.12	10.60	127	56035	151119	42414054
Finger amputation	15.05	10.60	7	56155	231	42564942
Sleep disorder therapy	14.93	10.60	30	56132	6864	42558309
Ceruloplasmin increased	14.78	10.60	4	56158	24	42565149
Drug resistance	14.75	10.60	14	56148	34234	42530939
Catecholamine crisis	14.72	10.60	5	56157	70	42565103
Loss of personal independence in daily activities	14.67	10.60	27	56135	49789	42515384
Wrong product administered	14.58	10.60	28	56134	6198	42558975
Haematochezia	14.42	10.60	35	56127	58401	42506772
Hypertension	14.25	10.60	304	55858	166900	42398273
Enterobacter pneumonia	14.23	10.60	9	56153	552	42564621
Open globe injury	14.22	10.60	5	56157	78	42565095
Death	14.10	10.60	494	55668	470691	42094482
Asthma	14.09	10.60	39	56123	62275	42502898
Anal sphincter atony	14.02	10.60	6	56156	162	42565011
Blood copper increased	14.01	10.60	4	56158	30	42565143
Neutropenia	13.99	10.60	182	55980	199249	42365924
Iron deficiency	13.97	10.60	39	56123	11022	42554151
Vitreous disorder	13.95	10.60	6	56156	164	42565009
Appendicitis	13.94	10.60	59	56103	20554	42544619
Corneal epithelium defect	13.89	10.60	8	56154	414	42564759
Respiratory arrest	13.86	10.60	74	56088	28350	42536823
Procedural hypotension	13.63	10.60	11	56151	992	42564181
Ventricular asystole	13.51	10.60	7	56155	293	42564880
Pulmonary oedema	13.51	10.60	118	56044	53154	42512019
Application site pain	13.49	10.60	16	56146	2313	42562860
Restlessness	13.49	10.60	75	56087	29174	42535999
Atrioventricular block complete	13.31	10.60	39	56123	11325	42553848
Behaviour disorder	13.30	10.60	29	56133	7025	42558148
Melaena	13.28	10.60	19	56143	38727	42526446
Encephalomalacia	13.09	10.60	11	56151	1050	42564123
Pancreatitis acute	13.02	10.60	15	56147	33549	42531624
Hyperaesthesia	13.01	10.60	26	56136	5926	42559247
Accidental exposure to product by child	12.99	10.60	13	56149	1554	42563619
Electrocardiogram T wave amplitude increased	12.98	10.60	5	56157	102	42565071
Pulseless electrical activity	12.95	10.60	32	56130	8405	42556768
Hypoxic-ischaemic encephalopathy	12.93	10.60	24	56138	5178	42559995
Phaeochromocytoma crisis	12.89	10.60	5	56157	104	42565069
Sinus bradycardia	12.89	10.60	46	56116	14807	42550366
Foetal exposure during pregnancy	12.76	10.60	27	56135	47284	42517889
Penile oedema	12.72	10.60	8	56154	486	42564687
Pleuropericarditis	12.63	10.60	7	56155	336	42564837
Blood 25-hydroxycholecalciferol decreased	12.63	10.60	7	56155	336	42564837
Vena cava injury	12.61	10.60	7	56155	337	42564836
Fatigue	12.51	10.60	459	55703	435182	42129991
Abdominal wall haemorrhage	12.37	10.60	8	56154	510	42564663
Myokymia	12.35	10.60	5	56157	117	42565056
Procedural pain	12.34	10.60	25	56137	5754	42559419
Lip haemorrhage	12.31	10.60	10	56152	910	42564263
Periorbital oedema	12.23	10.60	22	56140	4635	42560538
Delayed recovery from anaesthesia	12.17	10.60	11	56151	1158	42564015
Bacteroides infection	12.15	10.60	16	56146	2571	42562602
Infusion site pruritus	12.13	10.60	11	56151	1162	42564011
Foreign body sensation in eyes	11.99	10.60	10	56152	945	42564228
Hypophosphataemia	11.95	10.60	57	56105	20888	42544285
Activated partial thromboplastin time prolonged	11.93	10.60	47	56115	15856	42549317
Pulse absent	11.91	10.60	26	56136	6301	42558872
Disability	11.88	10.60	25	56137	5908	42559265
White blood cell count decreased	11.81	10.60	91	56071	110305	42454868
Rash	11.64	10.60	277	55885	276677	42288496
Erythema of eyelid	11.60	10.60	12	56150	1491	42563682
Anaemia	11.59	10.60	281	55881	279997	42285176
Torsade de pointes	11.55	10.60	31	56131	8563	42556610
Wrong route	11.54	10.60	3	56159	15	42565158
Illness	11.54	10.60	64	56098	24866	42540307
Mean arterial pressure increased	11.52	10.60	4	56158	60	42565113
Postictal state	11.41	10.60	10	56152	1010	42564163
Skin hyperpigmentation	11.30	10.60	20	56142	4161	42561012
Oesophageal obstruction	11.28	10.60	8	56154	594	42564579
Hyperparathyroidism secondary	11.25	10.60	13	56149	1829	42563344
Blindness transient	11.21	10.60	16	56146	2773	42562400
Abdominal discomfort	11.18	10.60	56	56106	75199	42489974
Cardiotoxicity	11.18	10.60	28	56134	7417	42557756
Transient ischaemic attack	11.12	10.60	17	56145	33722	42531451
Nightmare	11.04	10.60	10	56152	25002	42540171
Myocardial necrosis	11.02	10.60	6	56156	278	42564895
Hepatocellular injury	11.02	10.60	9	56153	23669	42541504
Lung opacity	11.01	10.60	24	56138	5813	42559360
Scrotal oedema	10.92	10.60	13	56149	1886	42563287
Blood uric acid increased	10.90	10.60	45	56117	15502	42549671
Brain hypoxia	10.88	10.60	8	56154	629	42564544
Foreign body in eye	10.75	10.60	5	56157	165	42565008
Peripheral nerve decompression	10.69	10.60	3	56159	21	42565152
Induration	10.69	10.60	10	56152	1100	42564073
Hypoaesthesia oral	10.61	10.60	21	56141	4752	42560421

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	1271.14	9.22	402	126848	5135	110456914
Anaphylactic reaction	438.49	9.22	597	126653	113703	110348346
Anaphylactic shock	419.41	9.22	398	126852	51148	110410901
Cardiac arrest	339.21	9.22	719	126531	196034	110266015
Hypotension	313.20	9.22	1312	125938	522537	109939512
Toxic anterior segment syndrome	296.36	9.22	121	127129	3333	110458716
Methaemoglobinaemia	272.17	9.22	155	127095	9013	110453036
Maternal exposure during delivery	265.85	9.22	113	127137	3452	110458597
Synovitis	264.52	9.22	12	127238	274080	110187969
Hypertrichosis	260.23	9.22	92	127158	1686	110460363
Hand deformity	216.08	9.22	8	127242	218498	110243551
Anaesthetic complication	209.76	9.22	96	127154	3510	110458539
Toxicity to various agents	204.52	9.22	1091	126159	479464	109982585
Systemic lupus erythematosus	196.89	9.22	29	127221	254309	110207740
Paraesthesia oral	195.74	9.22	217	127033	33454	110428595
Helicobacter infection	193.71	9.22	3	127247	181874	110280175
Pemphigus	190.09	9.22	15	127235	214555	110247494
Anti-cyclic citrullinated peptide antibody positive	182.25	9.22	6	127244	181978	110280071
Hepatic enzyme increased	179.88	9.22	72	127178	320820	110141229
Sedation complication	178.25	9.22	162	127088	19693	110442356
Joint swelling	175.41	9.22	151	127099	442694	110019355
Glossodynia	174.90	9.22	24	127226	221980	110240069
Macular degeneration	173.78	9.22	166	127084	21493	110440556
Chronic sinusitis	167.54	9.22	174	127076	24910	110437139
Duodenal ulcer perforation	167.51	9.22	9	127241	177691	110284358
Product formulation issue	165.17	9.22	61	127189	1273	110460776
Pericarditis	165.00	9.22	27	127223	219087	110242962
Procedural pain	156.76	9.22	199	127051	35366	110426683
Generalised tonic-clonic seizure	155.21	9.22	248	127002	54432	110407617
Kounis syndrome	154.26	9.22	92	127158	5833	110456216
Arthropathy	149.31	9.22	72	127178	287450	110174599
Contraindicated product administered	148.75	9.22	50	127200	248217	110213832
Bradycardia	146.99	9.22	453	126797	155064	110306985
Inspiratory capacity decreased	144.42	9.22	67	127183	2528	110459521
Creatinine renal clearance decreased	139.76	9.22	148	127102	21667	110440382
Folliculitis	139.72	9.22	15	127235	167638	110294411
Vaginal flatulence	139.30	9.22	114	127136	12030	110450019
Fear	139.18	9.22	152	127098	23041	110439008
Female genital tract fistula	131.37	9.22	126	127124	16393	110445656
Radiculopathy	127.11	9.22	133	127117	19203	110442846
Type 2 diabetes mellitus	126.59	9.22	25	127225	177207	110284842
General physical health deterioration	123.80	9.22	186	127064	425109	110036940
Rheumatoid factor positive	123.03	9.22	7	127243	131633	110330416
Muscle injury	121.52	9.22	11	127239	140796	110321253
Emotional distress	119.93	9.22	198	127052	44649	110417400
Proctitis	119.53	9.22	121	127129	16806	110445243
Rheumatic fever	116.17	9.22	6	127244	122573	110339476
Vaginal discharge	113.84	9.22	121	127129	17787	110444262
Ventricular tachycardia	113.08	9.22	205	127045	49804	110412245
Liver injury	112.19	9.22	19	127231	150394	110311655
Blood calcium decreased	112.08	9.22	170	127080	35675	110426374
Ventricular fibrillation	111.29	9.22	183	127067	41130	110420919
Therapeutic product effect decreased	108.52	9.22	74	127176	244242	110217807
Wound	108.21	9.22	68	127182	234369	110227680
Psoriatic arthropathy	105.64	9.22	47	127203	196714	110265335
Constipation	104.86	9.22	738	126512	357048	110105001
Impaired healing	102.49	9.22	49	127201	196668	110265381
Depressed level of consciousness	102.32	9.22	323	126927	111955	110350094
Unresponsive to stimuli	101.65	9.22	226	127024	63564	110398485
Renal injury	99.24	9.22	115	127135	18598	110443451
Stress cardiomyopathy	99.07	9.22	106	127144	15700	110446349
Anaesthetic complication neurological	98.33	9.22	39	127211	994	110461055
Facet joint syndrome	97.62	9.22	3	127247	96825	110365224
C-reactive protein abnormal	97.58	9.22	16	127234	129679	110332370
Abdominal discomfort	97.43	9.22	191	127059	393667	110068382
Drug intolerance	96.42	9.22	202	127048	406310	110055739
Anhedonia	92.38	9.22	101	127149	15327	110446722
Rheumatoid arthritis	92.12	9.22	126	127124	299487	110162562
Irritable bowel syndrome	91.71	9.22	37	127213	164178	110297871
Seizure	91.71	9.22	499	126751	220686	110241363
Tachycardia	91.08	9.22	507	126743	226138	110235911
Pulseless electrical activity	88.89	9.22	103	127147	16654	110445395
Drug ineffective for unapproved indication	88.40	9.22	290	126960	102548	110359501
Sleep disorder due to general medical condition, insomnia type	86.63	9.22	10	127240	105633	110356416
Ill-defined disorder	84.93	9.22	37	127213	156816	110305233
Dermatitis contact	84.69	9.22	92	127158	13861	110448188
Bursitis	83.50	9.22	23	127227	129895	110332154
Corneal oedema	81.90	9.22	49	127201	3124	110458925
Unevaluable event	80.33	9.22	197	127053	59030	110403019
Alopecia	79.33	9.22	190	127060	364563	110097486
Lip dry	78.37	9.22	11	127239	100072	110361977
Procedural hypotension	76.10	9.22	43	127207	2462	110459587
Inflammation	73.88	9.22	68	127182	193170	110268879
Swollen joint count increased	73.65	9.22	6	127244	83655	110378394
Insurance issue	71.56	9.22	74	127176	10538	110451511
Peripheral venous disease	71.44	9.22	7	127243	84110	110377939
Oral candidiasis	69.54	9.22	157	127093	44603	110417446
Obesity	69.32	9.22	22	127228	113329	110348720
Overdose	67.12	9.22	480	126770	233314	110228735
Status epilepticus	67.07	9.22	126	127124	31445	110430604
Musculoskeletal stiffness	66.35	9.22	139	127111	279683	110182366
Arthralgia	64.97	9.22	579	126671	779053	109682996
Sinus tachycardia	64.65	9.22	152	127098	44341	110417708
Hypercholesterolaemia	62.41	9.22	14	127236	90823	110371226
Haemorrhoids	60.95	9.22	130	127120	35542	110426507
Gait inability	60.95	9.22	41	127209	136335	110325714
Myelosuppression	60.07	9.22	17	127233	94323	110367726
Fibromyalgia	59.77	9.22	65	127185	170844	110291205
Apnoea	59.60	9.22	76	127174	13563	110448486
Pulse absent	59.21	9.22	69	127181	11223	110450826
Creatinine renal clearance increased	59.18	9.22	42	127208	3583	110458466
Incorrect route of product administration	59.00	9.22	185	127065	63876	110398173
Product adhesion issue	58.95	9.22	39	127211	2967	110459082
Drug ineffective	58.62	9.22	2218	125032	1518322	108943727
Cauda equina syndrome	57.99	9.22	34	127216	2088	110459961
Bronchospasm	57.30	9.22	115	127135	30124	110431925
Erythema	57.14	9.22	549	126701	290898	110171151
Orthostatic hypotension	57.08	9.22	187	127063	66062	110395987
Completed suicide	56.12	9.22	122	127128	242259	110219790
Abdominal pain upper	55.64	9.22	210	127040	348901	110113148
Liver disorder	55.63	9.22	49	127201	142194	110319855
Lagophthalmos	55.42	9.22	22	127228	562	110461487
Pulmonary fibrosis	55.35	9.22	24	127226	102018	110360031
Mental status changes	55.27	9.22	203	127047	75919	110386130
Sedation	55.02	9.22	191	127059	69492	110392557
Infusion site bruising	53.93	9.22	40	127210	3654	110458395
Infusion site pain	53.58	9.22	82	127168	17337	110444712
Electrocardiogram ST segment elevation	53.17	9.22	59	127191	9101	110452948
Hyperthermia malignant	52.00	9.22	40	127210	3860	110458189
Sulphaemoglobinaemia	51.58	9.22	21	127229	574	110461475
Stress	51.53	9.22	249	127001	105099	110356950
Endophthalmitis	51.47	9.22	55	127195	8132	110453917
Blister	51.37	9.22	116	127134	227260	110234789
Infusion site erythema	51.25	9.22	66	127184	11893	110450156
Infusion site swelling	51.20	9.22	60	127190	9817	110452232
Lower respiratory tract infection	50.97	9.22	129	127121	242977	110219072
Embolia cutis medicamentosa	50.92	9.22	24	127226	939	110461110
Cardiogenic shock	50.44	9.22	163	127087	57175	110404874
Grip strength decreased	50.03	9.22	15	127235	80159	110381890
Urinary tract infection	49.18	9.22	583	126667	325699	110136350
Proctalgia	49.04	9.22	68	127182	13154	110448895
C-reactive protein increased	47.76	9.22	113	127137	217806	110244243
Deep vein thrombosis postoperative	47.65	9.22	6	127244	59285	110402764
Cognitive disorder	47.32	9.22	213	127037	87298	110374751
Hypopyon	47.24	9.22	26	127224	1414	110460635
Accidental overdose	47.09	9.22	149	127101	51685	110410364
Ocular procedural complication	47.06	9.22	19	127231	508	110461541
Neurotoxicity	46.59	9.22	130	127120	42077	110419972
Lung disorder	46.50	9.22	85	127165	179962	110282087
Joint range of motion decreased	46.41	9.22	43	127207	121789	110340260
Extradural abscess	46.34	9.22	29	127221	2005	110460044
Type I hypersensitivity	45.69	9.22	46	127204	6347	110455702
Osteoarthritis	45.60	9.22	88	127162	182535	110279514
Trigemino-cardiac reflex	45.60	9.22	18	127232	453	110461596
Anterior chamber cell	45.52	9.22	24	127226	1197	110460852
Spinal cord infarction	45.00	9.22	23	127227	1075	110460974
Condition aggravated	44.58	9.22	587	126663	734249	109727800
Hypoxia	43.80	9.22	277	126973	129238	110332811
Extradural haematoma	43.71	9.22	34	127216	3335	110458714
Gastrointestinal disorder	43.63	9.22	138	127112	241814	110220235
Corneal epithelium defect	42.97	9.22	21	127229	891	110461158
Systemic toxicity	42.79	9.22	16	127234	346	110461703
Renal function test abnormal	42.53	9.22	52	127198	8894	110453155
Rash	42.39	9.22	677	126573	820287	109641762
Illness	42.20	9.22	197	127053	81974	110380075
Peripheral swelling	42.06	9.22	282	126968	403752	110058297
Pericardial effusion	41.89	9.22	153	127097	57064	110404985
Respiratory depression	41.87	9.22	105	127145	31896	110430153
Swelling	41.75	9.22	235	127015	350806	110111243
Nail disorder	41.72	9.22	8	127242	57927	110404122
Loss of consciousness	41.57	9.22	376	126874	195930	110266119
Anal inflammation	40.93	9.22	29	127221	2467	110459582
Stomatitis	40.85	9.22	166	127084	270076	110191973
Infusion site extravasation	40.43	9.22	58	127192	11576	110450473
Blood cholesterol increased	40.34	9.22	96	127154	184689	110277360
Musculoskeletal pain	39.23	9.22	96	127154	182927	110279122
Aqueous fibrin	38.81	9.22	13	127237	201	110461848
Haemodynamic instability	38.62	9.22	83	127167	22805	110439244
Hypersensitivity	38.62	9.22	289	126961	403709	110058340
Blepharospasm	38.60	9.22	8	127242	54843	110407206
Underdose	37.69	9.22	13	127237	63541	110398508
Suicide attempt	37.63	9.22	38	127212	103356	110358693
Lower limb fracture	37.38	9.22	20	127230	75328	110386721
Wheezing	37.19	9.22	159	127091	255071	110206978
Pain	37.10	9.22	1395	125855	953560	109508489
Electrocardiogram QRS complex prolonged	36.86	9.22	59	127191	12962	110449087
Retinal artery occlusion	36.83	9.22	34	127216	4215	110457834
Adverse event	36.27	9.22	43	127207	108766	110353283
Ophthalmoplegia	35.92	9.22	31	127219	3519	110458530
Arthritis	35.84	9.22	88	127162	167498	110294551
Pulmonary oedema	35.73	9.22	218	127032	100441	110361608
Infusion site pruritus	35.72	9.22	36	127214	4972	110457077
Red blood cell sedimentation rate increased	35.71	9.22	23	127227	78279	110383770
Peripheral nerve injury	35.67	9.22	20	127230	1128	110460921
Premature delivery	35.45	9.22	96	127154	30536	110431513
Post procedural complication	35.43	9.22	88	127162	26570	110435479
Treatment failure	34.94	9.22	182	127068	277052	110184997
Vitritis	34.91	9.22	27	127223	2626	110459423
Weight increased	34.72	9.22	312	126938	419332	110042717
Prescribed overdose	34.44	9.22	30	127220	87551	110374498
Paraplegia	34.39	9.22	39	127211	6161	110455888
Retinal vasculitis	34.05	9.22	24	127226	2025	110460024
Hepatitis	34.04	9.22	32	127218	90022	110372027
Nasopharyngitis	34.04	9.22	290	126960	394071	110067978
Night sweats	33.93	9.22	64	127186	133919	110328130
Fear of eating	33.70	9.22	15	127235	513	110461536
Onychomadesis	33.53	9.22	6	127244	45657	110416392
Wound infection	33.37	9.22	37	127213	96428	110365621
Coeliac disease	33.22	9.22	5	127245	43182	110418867
Drug hypersensitivity	33.19	9.22	348	126902	453742	110008307
Product preparation error	33.16	9.22	51	127199	10828	110451221
SARS-CoV-2 test negative	32.98	9.22	24	127226	2129	110459920
Adulterated product	32.87	9.22	19	127231	1136	110460913
Colitis	32.85	9.22	216	127034	102107	110359942
Infusion site haemorrhage	32.70	9.22	33	127217	4565	110457484
Loss of personal independence in daily activities	32.69	9.22	78	127172	149942	110312107
Multiple drug therapy	32.43	9.22	43	127207	7971	110454078
Product use issue	32.20	9.22	218	127032	311477	110150572
Diarrhoea	32.16	9.22	1033	126217	1138472	109323577
Balance disorder	32.09	9.22	237	127013	116323	110345726
Meningitis chemical	31.87	9.22	13	127237	357	110461692
Vasoplegia syndrome	31.51	9.22	35	127215	5404	110456645
Brain oedema	30.67	9.22	92	127158	31006	110431043
Circulatory collapse	30.66	9.22	114	127136	42879	110419170
Intentional product use issue	30.54	9.22	164	127086	247742	110214307
Respiratory tract infection bacterial	30.52	9.22	24	127226	2392	110459657
Vascular malformation	30.35	9.22	16	127234	798	110461251
Prescribed underdose	29.92	9.22	19	127231	65155	110396894
Psoriasis	29.55	9.22	74	127176	139919	110322130
Spinal epidural haemorrhage	29.54	9.22	12	127238	326	110461723
Hypoaesthesia oral	29.09	9.22	62	127188	16940	110445109
Hip arthroplasty	28.91	9.22	14	127236	55799	110406250
Visual acuity reduced	28.78	9.22	92	127158	32081	110429968
Sleep disorder	28.78	9.22	124	127126	198520	110263529
Wrong product administered	28.77	9.22	48	127202	10912	110451137
Paranasal cyst	28.77	9.22	16	127234	888	110461161
Postoperative delirium	28.59	9.22	16	127234	899	110461150
Seasonal allergy	28.24	9.22	67	127183	19655	110442394
Spinal epidural haematoma	28.19	9.22	20	127230	1705	110460344
Nystagmus	28.15	9.22	49	127201	11528	110450521
Tryptase increased	28.14	9.22	16	127234	927	110461122
Drug-induced liver injury	28.14	9.22	60	127190	120007	110342042
Oculocardiac reflex	27.96	9.22	9	127241	122	110461927
Incorrect drug administration rate	27.79	9.22	33	127217	5475	110456574
Anal sphincter atony	27.74	9.22	13	127237	502	110461547
Foreign body sensation in eyes	27.59	9.22	26	127224	3308	110458741
Injection related reaction	27.43	9.22	19	127231	1559	110460490
Blood phosphorus increased	27.28	9.22	59	127191	16281	110445768
Ventricular extrasystoles	27.25	9.22	72	127178	22569	110439480
COVID-19	27.04	9.22	414	126836	244646	110217403
Neuralgia	26.96	9.22	119	127131	48359	110413690
Hepatic cirrhosis	26.79	9.22	23	127227	67603	110394446
Leukopenia	26.72	9.22	85	127165	148706	110313343
Eye irritation	26.67	9.22	92	127158	33360	110428689
Lupus-like syndrome	26.62	9.22	7	127243	40785	110421264
Thrombocytopenia	26.45	9.22	265	126985	348620	110113429
Stridor	26.38	9.22	36	127214	6859	110455190
Purtscher retinopathy	26.38	9.22	10	127240	225	110461824
Confusional state	26.36	9.22	380	126870	468300	109993749
Mydriasis	26.20	9.22	70	127180	22087	110439962
Tenderness	26.17	9.22	84	127166	29353	110432696
Tracheitis	25.94	9.22	19	127231	1702	110460347
Infusion site mass	25.88	9.22	19	127231	1709	110460340
Knee arthroplasty	25.84	9.22	22	127228	64926	110397123
Delayed recovery from anaesthesia	25.84	9.22	21	127229	2194	110459855
Paralysis	25.67	9.22	56	127194	15544	110446505
Otitis media	25.58	9.22	37	127213	7439	110454610
Appendicolith	25.57	9.22	53	127197	14202	110447847
Anxiety	25.38	9.22	547	126703	344531	110117518
Asthma	25.37	9.22	176	127074	250115	110211934
Foot deformity	25.35	9.22	12	127238	48468	110413581
Chorioretinopathy	25.19	9.22	21	127229	2274	110459775
Product label on wrong product	25.18	9.22	7	127243	55	110461994
Pneumocephalus	25.07	9.22	12	127238	486	110461563
Multiple organ dysfunction syndrome	25.04	9.22	276	126974	151434	110310615
Upper respiratory tract infection	25.03	9.22	246	127004	131082	110330967
Accident	24.88	9.22	45	127205	10907	110451142
Analgesic therapy	24.86	9.22	36	127214	7248	110454801
Drug therapy	24.83	9.22	36	127214	7255	110454794
Respiratory tract infection	24.72	9.22	154	127096	71463	110390586
Diabetes insipidus	24.68	9.22	34	127216	6536	110455513
Economic problem	24.65	9.22	27	127223	4104	110457945
Decreased appetite	24.64	9.22	392	126858	475454	109986595
Product dose omission issue	24.62	9.22	513	126737	321269	110140780
Hepatotoxicity	24.59	9.22	22	127228	63378	110398671
Sleep disorder therapy	24.16	9.22	36	127214	7435	110454614
Asthenia	24.11	9.22	606	126644	688393	109773656
Epidural haemorrhage	24.04	9.22	11	127239	402	110461647
Neuromuscular block prolonged	24.02	9.22	16	127234	1231	110460818
Negative pressure pulmonary oedema	23.98	9.22	13	127237	686	110461363
Myoclonus	23.95	9.22	88	127162	32910	110429139
Infection	23.91	9.22	284	126966	361916	110100133
Autoimmune disorder	23.90	9.22	24	127226	65459	110396590
Bursitis infective	23.86	9.22	17	127233	1459	110460590
Back pain	23.84	9.22	577	126673	370419	110091630
Hyperphosphataemia	23.83	9.22	56	127194	16325	110445724
Platelet aggregation inhibition	23.80	9.22	9	127241	201	110461848
Cardiotoxicity	23.79	9.22	57	127193	16824	110445225
Procedural complication	23.68	9.22	38	127212	8367	110453682
Infusion related reaction	23.60	9.22	303	126947	380859	110081190
Fatigue	23.29	9.22	1153	126097	1214805	109247244
Pancreatitis acute	23.28	9.22	21	127229	60253	110401796
Trigeminal palsy	23.24	9.22	7	127243	75	110461974
Neuromuscular blockade	23.22	9.22	13	127237	731	110461318
Chemical burn	23.16	9.22	13	127237	735	110461314
Upper airway obstruction	22.98	9.22	18	127232	1784	110460265
Medical device site cellulitis	22.97	9.22	9	127241	222	110461827
Mastoiditis	22.84	9.22	21	127229	2590	110459459
Onychomycosis	22.64	9.22	8	127242	38523	110423526
Cardiac tamponade	22.63	9.22	44	127206	11263	110450786
Myasthenia gravis	22.52	9.22	65	127185	21446	110440603
Body tinea	22.48	9.22	19	127231	2096	110459953
Memory impairment	22.24	9.22	134	127116	196810	110265239
Cytomegalovirus infection	22.21	9.22	18	127232	54426	110407623
Punctate keratitis	22.12	9.22	15	127235	1189	110460860
Tubulointerstitial nephritis	22.07	9.22	18	127232	54266	110407783
Restlessness	22.00	9.22	125	127125	56134	110405915
Infusion site urticaria	21.98	9.22	15	127235	1201	110460848
Epidural analgesia	21.75	9.22	8	127242	165	110461884
Foetal heart rate abnormal	21.63	9.22	12	127238	663	110461386
Procedure aborted	21.40	9.22	8	127242	173	110461876
Acute kidney injury	21.39	9.22	562	126688	634868	109827181
Parophthalmia	21.31	9.22	11	127239	525	110461524
Blood pressure decreased	21.16	9.22	214	127036	114877	110347172
Cholestasis	20.97	9.22	26	127224	64492	110397557
Sciatica	20.97	9.22	47	127203	92352	110369697
Staphylococcal infection	20.86	9.22	145	127105	69799	110392250
Disease progression	20.80	9.22	180	127070	243854	110218195
Blindness	20.79	9.22	90	127160	36269	110425780
Eye pain	20.71	9.22	113	127137	49986	110412063
Rectal haemorrhage	20.70	9.22	220	127030	119613	110342436
Brain stem syndrome	20.68	9.22	15	127235	1324	110460725
Febrile neutropenia	20.45	9.22	493	126757	316274	110145775
Spinal anaesthesia	20.34	9.22	7	127243	118	110461931
Hepatocellular injury	20.34	9.22	17	127233	50625	110411424
Renal cyst haemorrhage	20.29	9.22	12	127238	749	110461300
Exostosis	20.28	9.22	14	127236	45942	110416107
Hypertensive crisis	20.28	9.22	68	127182	24304	110437745
Shock	20.26	9.22	118	127132	53470	110408579
Pneumocystis jirovecii pneumonia	20.25	9.22	12	127238	42723	110419326
Medical device site abscess	20.24	9.22	8	127242	202	110461847
Back injury	20.18	9.22	15	127235	47384	110414665
Bundle branch block left	19.79	9.22	45	127205	12843	110449206
Nerve root injury	19.78	9.22	6	127244	66	110461983
Spinal cord compression	19.73	9.22	33	127217	7519	110454530
Product administration error	19.68	9.22	90	127160	37127	110424922
Taste disorder	19.57	9.22	28	127222	65359	110396690
Infusion site discharge	19.50	9.22	17	127233	1956	110460093
Airway peak pressure increased	19.40	9.22	11	127239	634	110461415
Mean arterial pressure decreased	19.30	9.22	10	127240	481	110461568
Macular ischaemia	19.17	9.22	8	127242	233	110461816
Therapy partial responder	19.13	9.22	89	127161	36972	110425077
Drug resistance	19.09	9.22	22	127228	56352	110405697
Multiple allergies	19.03	9.22	43	127207	12220	110449829
Interstitial lung disease	18.96	9.22	89	127161	139245	110322804
Epilepsy	18.87	9.22	56	127194	100153	110361896
Injection site reaction	18.86	9.22	47	127203	89023	110373026
Laryngospasm	18.82	9.22	25	127225	4643	110457406
Respiratory acidosis	18.75	9.22	46	127204	13780	110448269
Respiratory arrest	18.67	9.22	123	127127	58176	110403873
Inadequate analgesia	18.66	9.22	26	127224	5051	110456998
Product contamination microbial	18.61	9.22	13	127237	1081	110460968
Kidney congestion	18.60	9.22	10	127240	519	110461530
Intentional self-injury	18.47	9.22	10	127240	37419	110424630
Frequent bowel movements	18.43	9.22	143	127107	71247	110390802
Sinus bradycardia	18.43	9.22	75	127175	29408	110432641
Atonic urinary bladder	18.40	9.22	7	127243	159	110461890
C-reactive protein	18.34	9.22	6	127244	30325	110431724
Liver function test abnormal	18.29	9.22	32	127218	68918	110393131
Hypophosphataemia	18.11	9.22	81	127169	33101	110428948
Photophobia	18.09	9.22	68	127182	25703	110436346
Blood copper increased	18.01	9.22	5	127245	39	110462010
Eyelid ptosis	17.72	9.22	44	127206	13283	110448766
Neutropenia	17.62	9.22	314	126936	374306	110087743
Skin test positive	17.46	9.22	14	127236	1435	110460614
Vision blurred	17.45	9.22	226	127024	128796	110333253
Vascular compression	17.45	9.22	11	127239	770	110461279
Activated partial thromboplastin time prolonged	17.38	9.22	61	127189	22307	110439742
Thyroid atrophy	17.31	9.22	8	127242	299	110461750
Vascular anastomotic haemorrhage	17.17	9.22	8	127242	305	110461744
Bone marrow failure	17.09	9.22	25	127225	57823	110404226
Corneal opacity	17.05	9.22	13	127237	1238	110460811
Diplopia	16.99	9.22	94	127156	41800	110420249
Hyperaesthesia	16.89	9.22	46	127204	14681	110447368
Gastroenteritis viral	16.87	9.22	76	127174	31150	110430899
Intracranial hypotension	16.85	9.22	10	127240	628	110461421
Appendicitis	16.69	9.22	71	127179	28393	110433656
Metastases to liver	16.68	9.22	10	127240	35376	110426673
Chills	16.64	9.22	310	126940	190270	110271779
Depression	16.55	9.22	261	126989	317074	110144975
Quadriplegia	16.48	9.22	22	127228	4105	110457944
Dry mouth	16.37	9.22	149	127101	199799	110262250
Drug reaction with eosinophilia and systemic symptoms	16.10	9.22	45	127205	82050	110379999
Discomfort	15.88	9.22	164	127086	214543	110247506
Spinal meningeal cyst	15.87	9.22	6	127244	134	110461915
Atrioventricular block complete	15.81	9.22	55	127195	20027	110442022
Cyanosis	15.78	9.22	72	127178	29669	110432380
Respiratory tract infection viral	15.78	9.22	26	127224	5852	110456197
Abortion spontaneous	15.73	9.22	10	127240	34272	110427777
Cardio-respiratory arrest	15.71	9.22	203	127047	115633	110346416
Anterior chamber fibrin	15.63	9.22	7	127243	243	110461806
Nail bed tenderness	15.61	9.22	8	127242	376	110461673
Vocal cord dysfunction	15.49	9.22	11	127239	939	110461110
Pleural effusion	15.49	9.22	289	126961	177420	110284629
Heparin-induced thrombocytopenia	15.49	9.22	38	127212	11386	110450663
Skin infection	15.48	9.22	59	127191	22450	110439599
Vitreous disorder	15.48	9.22	8	127242	383	110461666
Lip haemorrhage	15.34	9.22	13	127237	1439	110460610
Anal skin tags	15.30	9.22	9	127241	556	110461493
Skin warm	15.18	9.22	33	127217	9137	110452912
Electrocardiogram ST-T segment depression	15.18	9.22	4	127246	25	110462024
Behaviour disorder	15.16	9.22	34	127216	9613	110452436
Injection site joint infection	15.13	9.22	5	127245	74	110461975
Anaphylactoid shock	15.12	9.22	11	127239	975	110461074
Ceruloplasmin increased	14.92	9.22	4	127246	27	110462022
Hypoxic-ischaemic encephalopathy	14.83	9.22	32	127218	8815	110453234
Swelling of eyelid	14.69	9.22	27	127223	6626	110455423
Product administered at inappropriate site	14.67	9.22	24	127226	5369	110456680
Seizure like phenomena	14.65	9.22	16	127234	2425	110459624
Apnoeic attack	14.64	9.22	10	127240	802	110461247
Infusion site discomfort	14.58	9.22	14	127236	1823	110460226
Thrombosis	14.56	9.22	190	127060	108472	110353577
Torsade de pointes	14.53	9.22	58	127192	22542	110439507
Anaesthetic complication pulmonary	14.47	9.22	6	127244	172	110461877
Lethargy	14.42	9.22	168	127082	93408	110368641
Colitis ulcerative	14.29	9.22	144	127106	77219	110384830
Physical disability	14.27	9.22	23	127227	5083	110456966
Neuroleptic malignant syndrome	14.22	9.22	11	127239	34048	110428001
Vitamin D increased	14.19	9.22	10	127240	843	110461206
Product distribution issue	14.14	9.22	21	127229	4325	110457724
Oesophageal injury	14.13	9.22	7	127243	306	110461743
Drug tolerance decreased	14.12	9.22	7	127243	27533	110434516
Reperfusion arrhythmia	14.11	9.22	7	127243	307	110461742
Respiratory distress	14.10	9.22	131	127119	68743	110393306
Rhabdomyolysis	14.08	9.22	81	127169	120320	110341729
Finger amputation	13.99	9.22	10	127240	863	110461186
Mouth swelling	13.97	9.22	28	127222	7326	110454723
Catecholamine crisis	13.93	9.22	5	127245	96	110461953
Diabetic foot infection	13.87	9.22	10	127240	874	110461175
Spinal cord injury	13.81	9.22	13	127237	1652	110460397
Application site alopecia	13.81	9.22	4	127246	37	110462012
Miosis	13.81	9.22	56	127194	21927	110440122
Vaginal abscess	13.74	9.22	8	127242	485	110461564
Insomnia	13.73	9.22	313	126937	360277	110101772
Airway complication of anaesthesia	13.72	9.22	9	127241	675	110461374
Scrotal oedema	13.70	9.22	13	127237	1668	110460381
Blood uric acid increased	13.64	9.22	55	127195	21474	110440575
Agitation	13.64	9.22	194	127056	112857	110349192
Implant site bruising	13.60	9.22	7	127243	332	110461717
Hypertensive emergency	13.59	9.22	18	127232	3333	110458716
Respiratory failure	13.54	9.22	334	126916	214998	110247051
Obstruction	13.54	9.22	24	127226	5728	110456321
Eyelid contusion	13.51	9.22	5	127245	105	110461944
Deafness permanent	13.41	9.22	10	127240	921	110461128
Vena cava injury	13.35	9.22	7	127243	345	110461704
Progressive multifocal leukoencephalopathy	13.32	9.22	6	127244	24950	110437099
Familial periodic paralysis	13.22	9.22	7	127243	352	110461697
Induration	13.20	9.22	15	127235	2374	110459675
Iron deficiency	13.18	9.22	49	127201	18427	110443622
Ventricular tachyarrhythmia	13.16	9.22	8	127242	525	110461524
Electrocardiogram ST segment depression	13.13	9.22	23	127227	5438	110456611
Drug level increased	13.11	9.22	97	127153	47622	110414427
Retinal detachment	13.06	9.22	35	127215	11065	110450984
Left ventricle outflow tract obstruction	13.02	9.22	8	127242	535	110461514
Application site pain	13.01	9.22	23	127227	5476	110456573
Eclampsia	12.99	9.22	7	127243	365	110461684
Lung opacity	12.97	9.22	36	127214	11616	110450433
Transferrin decreased	12.96	9.22	8	127242	540	110461509
Repetitive strain injury	12.94	9.22	6	127244	226	110461823
Abdominal wall haemorrhage	12.93	9.22	9	127241	744	110461305
Quadriparesis	12.88	9.22	21	127229	4686	110457363
Laryngitis	12.85	9.22	18	127232	42393	110419656
Dysphoria	12.85	9.22	25	127225	6403	110455646
Pancytopenia	12.83	9.22	167	127083	209446	110252603
Axillary nerve injury	12.72	9.22	4	127246	50	110461999
Cholestasis of pregnancy	12.70	9.22	11	127239	1254	110460795
Accidental exposure to product by child	12.70	9.22	17	127233	3181	110458868
Localised infection	12.69	9.22	89	127161	42959	110419090
Vascular stenosis	12.67	9.22	9	127241	769	110461280
Heliotrope rash	12.65	9.22	6	127244	238	110461811
Spinal cord ischaemia	12.65	9.22	6	127244	238	110461811
Retrograde amnesia	12.57	9.22	9	127241	778	110461271
Brain herniation	12.57	9.22	30	127220	8833	110453216
Anal ulcer	12.50	9.22	13	127237	1863	110460186
Intraocular pressure increased	12.50	9.22	34	127216	10842	110451207
Streptococcal infection	12.47	9.22	34	127216	10856	110451193
Phrenic nerve paralysis	12.45	9.22	8	127242	579	110461470
Infusion site streaking	12.41	9.22	8	127242	582	110461467
Prostate cancer	12.41	9.22	15	127235	37626	110424423
Pregnancy	12.40	9.22	25	127225	51042	110411007
Ejection fraction decreased	12.34	9.22	85	127165	40795	110421254
Bacteroides infection	12.34	9.22	16	127234	2903	110459146
Pseudomonas infection	12.32	9.22	64	127186	27789	110434260
Hyperlipidaemia	12.32	9.22	77	127173	35771	110426278
Superinfection	12.24	9.22	23	127227	5740	110456309
Enterobacter pneumonia	12.23	9.22	8	127242	597	110461452
Finger deformity	12.22	9.22	12	127238	33080	110428969
Vascular resistance systemic decreased	12.16	9.22	6	127244	260	110461789
Administration site pain	12.14	9.22	9	127241	822	110461227
Exophthalmos	12.10	9.22	14	127236	2259	110459790
Osteonecrosis of jaw	12.10	9.22	23	127227	47994	110414055
Cellulitis	12.06	9.22	208	127042	125808	110336241
Ventricular asystole	12.06	9.22	7	127243	422	110461627
Harlequin syndrome	12.05	9.22	6	127244	265	110461784
Schizophrenia	12.05	9.22	5	127245	21821	110440228
Agranulocytosis	12.00	9.22	34	127216	61726	110400323
Deafness neurosensory	12.00	9.22	31	127219	9588	110452461
Vitreous floaters	11.98	9.22	30	127220	9104	110452945
Body dysmorphic disorder	11.97	9.22	7	127243	428	110461621
Wrong route	11.95	9.22	3	127247	15	110462034
Uveitis	11.94	9.22	5	127245	21705	110440344
Oxidative stress	11.93	9.22	4	127246	62	110461987
Intellectual disability	11.92	9.22	13	127237	1966	110460083
Haematochezia	11.91	9.22	193	127057	115331	110346718
Allergy to immunoglobulin therapy	11.88	9.22	5	127245	149	110461900
Air embolism	11.82	9.22	8	127242	632	110461417
Spinal stroke	11.82	9.22	4	127246	64	110461985
Myokymia	11.82	9.22	5	127245	151	110461898
Irregular breathing	11.81	9.22	8	127242	633	110461416
Glossoptosis	11.77	9.22	6	127244	279	110461770
Infusion site rash	11.76	9.22	14	127236	2329	110459720
Lung neoplasm malignant	11.68	9.22	13	127237	33829	110428220
Pulmonary toxicity	11.67	9.22	3	127247	17743	110444306
Nail bed inflammation	11.65	9.22	13	127237	2017	110460032
Road traffic accident	11.64	9.22	74	127176	107324	110354725
Intelligence test abnormal	11.63	9.22	3	127247	17	110462032
Accelerated idioventricular rhythm	11.63	9.22	6	127244	286	110461763
Speech disorder	11.56	9.22	115	127135	61454	110400595
Femoral nerve injury	11.54	9.22	4	127246	69	110461980
Pustule	11.50	9.22	17	127233	3487	110458562
Kidney infection	11.44	9.22	59	127191	25540	110436509
Erythema of eyelid	11.44	9.22	18	127232	3897	110458152
Sensory loss	11.43	9.22	52	127198	21405	110440644
Arthritis infective	11.39	9.22	32	127218	10397	110451652
Blood 25-hydroxycholecalciferol decreased	11.38	9.22	7	127243	469	110461580
Allodynia	11.38	9.22	13	127237	2070	110459979
Aortic stenosis	11.37	9.22	37	127213	13022	110449027
Spinal cord oedema	11.36	9.22	7	127243	471	110461578
Total lung capacity decreased	11.10	9.22	25	127225	7089	110454960
Vasculitis	11.10	9.22	15	127235	35858	110426191
Encephalomalacia	11.09	9.22	11	127239	1491	110460558
Calcinosis	11.08	9.22	15	127235	2837	110459212
Scleral hyperaemia	10.99	9.22	6	127244	321	110461728
Swelling face	10.97	9.22	158	127092	92163	110369886
Monoplegia	10.94	9.22	20	127230	4889	110457160
Orbital infection	10.89	9.22	5	127245	184	110461865
Abnormal sensation in eye	10.87	9.22	13	127237	2173	110459876
Dermatitis atopic	10.82	9.22	58	127192	25483	110436566
Adverse drug reaction	10.80	9.22	74	127176	105485	110356564
Full blood count abnormal	10.79	9.22	31	127219	56021	110406028
Conjunctival oedema	10.76	9.22	11	127239	1545	110460504
Disease recurrence	10.72	9.22	35	127215	60749	110401300
Nasal mucosal disorder	10.71	9.22	12	127238	1871	110460178
Arthritis bacterial	10.66	9.22	32	127218	10788	110451261
Myotonic dystrophy	10.65	9.22	5	127245	194	110461855
Blindness transient	10.51	9.22	22	127228	5934	110456115
Acute pulmonary oedema	10.44	9.22	43	127207	16953	110445096
Sinusitis	10.42	9.22	429	126821	296259	110165790
Varicose vein	10.40	9.22	24	127226	6916	110455133
End-tidal CO2 decreased	10.39	9.22	4	127246	94	110461955
Sinus arrest	10.37	9.22	18	127232	4224	110457825
Arthritis fungal	10.37	9.22	5	127245	206	110461843
Laboratory test abnormal	10.35	9.22	22	127228	44057	110417992
Intentional product misuse to child	10.35	9.22	5	127245	207	110461842
Opisthotonus	10.34	9.22	8	127242	778	110461271
Device infusion issue	10.32	9.22	15	127235	3030	110459019
Nerve block	10.32	9.22	8	127242	781	110461268
Intraocular pressure fluctuation	10.31	9.22	4	127246	96	110461953
Keratitis	10.27	9.22	20	127230	5124	110456925
Hypoaesthesia	10.27	9.22	279	126971	313944	110148105
Iron binding capacity total decreased	10.26	9.22	7	127243	560	110461489
Accidental exposure to product	10.18	9.22	95	127155	49913	110412136
Bacterial infection	10.16	9.22	89	127161	45947	110416102
Pemphigoid	10.12	9.22	5	127245	19702	110442347
Gastrooesophageal reflux disease	10.07	9.22	146	127104	179830	110282219
Hypercapnia	10.06	9.22	32	127218	11127	110450922
Meningitis	10.05	9.22	33	127217	11669	110450380
Endocrine ophthalmopathy	10.03	9.22	10	127240	1363	110460686
Impaired quality of life	10.02	9.22	64	127186	29953	110432096
Foetal death	10.01	9.22	3	127247	16042	110446007
Peripheral nerve decompression	10.01	9.22	4	127246	104	110461945
Anaesthetic complication cardiac	9.98	9.22	4	127246	105	110461944
Ventricular hypokinesia	9.97	9.22	32	127218	11182	110450867
Angioedema	9.94	9.22	164	127086	98336	110363713
Open globe injury	9.94	9.22	5	127245	226	110461823
Cerebral congestion	9.92	9.22	5	127245	227	110461822
Infection susceptibility increased	9.90	9.22	18	127232	4380	110457669
Coccygectomy	9.89	9.22	3	127247	33	110462016
Sympathectomy	9.89	9.22	3	127247	33	110462016
Dystonia	9.87	9.22	57	127193	25748	110436301
Corneal abrasion	9.82	9.22	10	127240	1399	110460650
Injection site joint swelling	9.81	9.22	3	127247	34	110462015
Pupillary reflex impaired	9.77	9.22	17	127233	3998	110458051
Pneumonia mycoplasmal	9.74	9.22	11	127239	1730	110460319
Atelectasis	9.73	9.22	74	127176	36638	110425411
Postictal state	9.71	9.22	13	127237	2433	110459616
Tremor	9.71	9.22	303	126947	201929	110260120
Procedural anxiety	9.70	9.22	8	127242	853	110461196
Perineal cyst	9.68	9.22	5	127245	239	110461810
Tachypnoea	9.67	9.22	78	127172	39317	110422732
Renal transplant	9.62	9.22	15	127235	3223	110458826
Liver function test increased	9.60	9.22	61	127189	88487	110373562
Mean arterial pressure increased	9.57	9.22	4	127246	117	110461932
Panniculitis	9.57	9.22	3	127247	15579	110446470
Victim of chemical submission	9.56	9.22	8	127242	871	110461178
Ingrowing nail	9.54	9.22	15	127235	3247	110458802
Procedural haemorrhage	9.53	9.22	20	127230	5407	110456642
Testicular haemorrhage	9.51	9.22	5	127245	248	110461801
Incision site rash	9.43	9.22	3	127247	39	110462010
Hyperparathyroidism secondary	9.39	9.22	15	127235	3289	110458760
Drug eruption	9.39	9.22	31	127219	53628	110408421
Infusion site nodule	9.38	9.22	6	127244	431	110461618
Walking aid user	9.37	9.22	9	127241	25066	110436983
Spinal osteoarthritis	9.36	9.22	47	127203	20136	110441913
Pancreatitis	9.36	9.22	66	127184	93467	110368582
Spinal stenosis	9.28	9.22	45	127205	19011	110443038
Rectal prolapse	9.23	9.22	13	127237	2550	110459499
Renal failure	9.23	9.22	333	126917	226241	110235808

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AG04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
ATC	A06AX01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Other drugs for constipation
FDA CS	M0000728	Allergens
FDA CS	M0009417	Glycerol
MeSH PA	D003451	Cryoprotective Agents
MeSH PA	D012997	Solvents
MeSH PA	D020011	Protective Agents
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity
FDA PE	N0000185001	Increased IgG Production
FDA EPC	N0000185370	Non-Standardized Chemical Allergen
CHEBI has role	CHEBI:25728	osmolyte
CHEBI has role	CHEBI:27780	detergent
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:46787	solvent
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:50503	laxative
CHEBI has role	CHEBI:64946	anti-HIV agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:75772	<em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role	CHEBI:76971	<em>Escherichia coli</em> metabolite
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:84735	algal metabolite
CHEBI has role	CHEBI:176497	geroprotector

Related Drugs by ATC class:

A06AG Enemas 5 drugs

bisacodyl dantron docusate sodium sodium phosphate sorbitol

A06AX Other drugs for constipation 7 drugs

elobixibat linaclotide lubiprostone plecanatide prucalopride tegaserod tenapanor

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017411	VUID
N0000145799	NUI
D00028	KEGG_DRUG
4017411	VANDF
C0017861	UMLSCUI
CHEBI:17754	CHEBI
CRY	PDB_CHEM_ID
CHEMBL692	ChEMBL_ID
753	PUBCHEM_CID
DB09462	DRUGBANK_ID
D005990	MESH_DESCRIPTOR_UI
5195	IUPHAR_LIGAND_ID
4910	RXNORM
108842	MMSL
399991	MMSL
4792	MMSL
52080	MMSL
602	MMSL
d00652	MMSL
001176	NDDF
001893	NDDF
002240	NDDF
002291	NDDF
002469	NDDF
004085	NDDF
404833002	SNOMEDCT_US
80582002	SNOMEDCT_US
444	INN_ID
PDC6A3C0OX	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
REFRESH TEARS PF	HUMAN OTC DRUG LABEL	2	0023-3110	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH TEARS PF	HUMAN OTC DRUG LABEL	2	0023-3110	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE	HUMAN OTC DRUG LABEL	2	0023-3240	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Optive	HUMAN OTC DRUG LABEL	2	0023-3416	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Relieva PF Xtra	HUMAN OTC DRUG LABEL	2	0023-3782	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Relieva PF Xtra	HUMAN OTC DRUG LABEL	2	0023-3782	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Optive Mega-3 PF	HUMAN OTC DRUG LABEL	3	0023-3988	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH Optive Mega-3	HUMAN OTC DRUG LABEL	3	0023-4230	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	12 sections
Refresh RELIEVA PF	HUMAN OTC DRUG LABEL	2	0023-4515	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH OPTIVE Drops	HUMAN OTC DRUG LABEL	2	0023-5459	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH Optive Mega-3	HUMAN OTC DRUG LABEL	3	0023-5773	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Relieva	HUMAN OTC DRUG LABEL	2	0023-6630	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Relieva Preservative Free	HUMAN OTC DRUG LABEL	2	0023-6634	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Relieva Preservative Free	HUMAN OTC DRUG LABEL	2	0023-6634	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Digital	HUMAN OTC DRUG LABEL	3	0023-6952	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Refresh Digital PF	HUMAN OTC DRUG LABEL	3	0023-6954	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
REFRESH Optive Mega-3	HUMAN OTC DRUG LABEL	3	0023-7151	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	Export only	1 sections
Refresh RELIEVA PF	HUMAN OTC DRUG LABEL	2	0023-9537	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC Monograph Drug	11 sections
GenTeal Tears (Moderate)	HUMAN OTC DRUG LABEL	3	0065-0426	SOLUTION/ DROPS	2 mg	OPHTHALMIC	OTC Monograph Drug	13 sections
Good Sense HemorrhoidalMaximum Strength Pain Relief	HUMAN OTC DRUG LABEL	4	0113-0944	CREAM	14.40 g	TOPICAL	OTC Monograph Drug	14 sections
Fleet	HUMAN OTC DRUG LABEL	1	0132-0075	SUPPOSITORY	2 g	RECTAL	OTC Monograph Drug	15 sections
FLEET	HUMAN OTC DRUG LABEL	1	0132-0090	SUPPOSITORY	2 g	RECTAL	Export only	15 sections
Fleet	HUMAN OTC DRUG LABEL	1	0132-0185	LIQUID	5.40 g	RECTAL	OTC Monograph Drug	13 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	1	0132-0190	LIQUID	2.80 g	RECTAL	OTC Monograph Drug	12 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	1	0132-0195	LIQUID	2.80 g	RECTAL	OTC Monograph Drug	12 sections

Ask DrugCentral

Your question

DrugCentral answer

About Ask DrugCentral

General architecture

Using the assistant

glycerol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: