glycerol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1316 56-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glycerol
  • glycerin
  • glycerine
  • propane-1,2,3-triol
  • 1,2,3-triglycerol
  • glycyl alcohol
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
  • Molecular weight: 92.09
  • Formula: C3H8O3
  • CLOGP: -1.54
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: 1.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 500 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 47
kinase-selectivity-class ACVRL1,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK8,CDK9,CHUK,CLK2,DYRK1A,EPHB4,HASPIN,INSR,IRAK1,IRAK3,IRAK4,KIT,MAP2K6,MAP3K21,MAPK11,PIK3CD,PRKDC,SYK,TEK,TGFBR1,TYRO3,ZAP70 35
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
May 6, 1982 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 814.28 9.26 253 97760 3247 90527187
Macular degeneration 538.62 9.26 394 97619 37576 90492858
Pemphigus 291.69 9.26 15 97998 326849 90203585
Maternal exposure during delivery 291.05 9.26 121 97892 3725 90526709
Hand deformity 279.85 9.26 9 98004 296353 90234081
Systemic lupus erythematosus 270.13 9.26 36 97977 361860 90168574
Glossodynia 265.80 9.26 22 97991 321757 90208677
Synovitis 263.10 9.26 26 97987 329726 90200708
Anaphylactic reaction 224.01 9.26 366 97647 87158 90443276
Anti-cyclic citrullinated peptide antibody positive 223.83 9.26 7 98006 236426 90294008
Contraindicated product administered 218.23 9.26 41 97972 320098 90210336
Pericarditis 216.25 9.26 21 97992 270130 90260304
Hypotension 209.10 9.26 799 97214 324598 90205836
Toxic anterior segment syndrome 205.39 9.26 81 97932 2169 90528265
Duodenal ulcer perforation 204.41 9.26 8 98005 221280 90309154
Cardiac arrest 204.09 9.26 389 97624 104546 90425888
Anaphylactic shock 203.70 9.26 209 97804 31408 90499026
Joint swelling 200.48 9.26 151 97862 503149 90027285
Hepatic enzyme increased 198.68 9.26 71 97942 360665 90169769
Chronic sinusitis 195.94 9.26 180 97833 23622 90506812
Sedation complication 185.88 9.26 151 97862 16793 90513641
Arthropathy 180.77 9.26 85 97928 366157 90164277
Paraesthesia oral 175.13 9.26 193 97820 31466 90498968
Folliculitis 171.39 9.26 13 98000 204340 90326094
Helicobacter infection 168.14 9.26 23 97990 226827 90303607
Wound 162.81 9.26 62 97951 302918 90227516
Kounis syndrome 159.09 9.26 70 97943 2483 90527951
Creatinine renal clearance decreased 153.77 9.26 142 97871 18757 90511677
Rheumatoid factor positive 152.64 9.26 8 98005 171642 90358792
Procedural pain 151.97 9.26 184 97829 33176 90497258
Drug intolerance 144.17 9.26 163 97850 447428 90083006
Vaginal flatulence 143.66 9.26 115 97898 12523 90517911
Constipation 138.13 9.26 635 97378 279760 90250674
Muscle injury 138.04 9.26 15 97998 176639 90353795
Liver injury 137.13 9.26 13 98000 170554 90359880
Rheumatic fever 136.58 9.26 7 98006 153114 90377320
Therapeutic product effect decreased 136.02 9.26 65 97948 277506 90252928
Methaemoglobinaemia 134.56 9.26 72 97941 3943 90526491
Impaired healing 134.26 9.26 43 97970 234156 90296278
General physical health deterioration 131.96 9.26 114 97899 355001 90175433
Female genital tract fistula 131.50 9.26 127 97886 17741 90512693
Radiculopathy 129.60 9.26 128 97885 18377 90512057
Infusion site pain 128.08 9.26 131 97882 19607 90510827
Psoriatic arthropathy 125.54 9.26 45 97968 228290 90302144
Proctitis 124.82 9.26 115 97898 15144 90515290
Abdominal discomfort 120.55 9.26 207 97806 477121 90053313
Alopecia 118.48 9.26 222 97791 494849 90035585
Type 2 diabetes mellitus 117.05 9.26 37 97976 203207 90327227
Hypertrichosis 116.88 9.26 48 97965 1431 90529003
Depressed level of consciousness 115.47 9.26 248 97765 72536 90457898
Blood calcium decreased 114.54 9.26 152 97861 30030 90500404
Vaginal discharge 113.47 9.26 122 97891 19342 90511092
Infusion site swelling 111.08 9.26 96 97917 11624 90518810
Sleep disorder due to general medical condition, insomnia type 108.42 9.26 8 98005 128686 90401748
Generalised tonic-clonic seizure 107.46 9.26 159 97854 34744 90495690
Toxicity to various agents 106.09 9.26 601 97412 287245 90243189
Swelling 105.54 9.26 182 97831 418876 90111558
Anaesthetic complication 105.16 9.26 52 97961 2413 90528021
Irritable bowel syndrome 102.49 9.26 48 97965 207400 90323034
Insurance issue 100.32 9.26 88 97925 10870 90519564
Infusion site erythema 96.55 9.26 95 97918 13575 90516859
Stress cardiomyopathy 96.54 9.26 94 97919 13261 90517173
Infusion site extravasation 94.67 9.26 83 97930 10245 90520189
Ill-defined disorder 94.12 9.26 41 97972 184850 90345584
Swollen joint count increased 93.43 9.26 7 98006 111199 90419235
Orthostatic hypotension 89.97 9.26 162 97851 41665 90488769
C-reactive protein abnormal 89.62 9.26 15 97998 127414 90403020
Urinary tract infection 89.24 9.26 601 97412 305031 90225403
Sedation 86.81 9.26 173 97840 47998 90482436
Blister 85.17 9.26 90 97923 254908 90275526
Oral candidiasis 84.94 9.26 144 97869 35311 90495123
Sinusitis 84.74 9.26 648 97365 342440 90187994
Pulseless electrical activity 84.32 9.26 73 97940 8859 90521575
Infusion site pruritus 84.31 9.26 65 97948 6700 90523734
Hypersensitivity 84.30 9.26 234 97779 454443 90075991
Rheumatoid arthritis 83.72 9.26 166 97847 362448 90167986
Bradycardia 83.42 9.26 239 97774 83608 90446826
Dermatitis contact 82.40 9.26 87 97926 13508 90516926
Lip dry 75.33 9.26 10 98003 100945 90429489
Inflammation 73.01 9.26 52 97961 178540 90351894
Treatment failure 72.87 9.26 136 97877 303792 90226642
Blood cholesterol increased 72.20 9.26 71 97942 207941 90322493
Peripheral venous disease 71.30 9.26 5 98008 83916 90446518
Musculoskeletal stiffness 70.82 9.26 133 97880 296399 90234035
Infusion site bruising 70.31 9.26 49 97964 4323 90526111
Infusion site haemorrhage 69.65 9.26 53 97960 5358 90525076
Corneal oedema 69.12 9.26 36 97977 1865 90528569
Bursitis 68.91 9.26 28 97985 131626 90398808
Illness 68.71 9.26 220 97793 81749 90448685
Completed suicide 67.96 9.26 36 97977 145022 90385412
Stomatitis 66.66 9.26 122 97891 274576 90255858
Lower respiratory tract infection 66.64 9.26 105 97908 250554 90279880
Gait inability 66.22 9.26 38 97975 146418 90384016
Procedural hypotension 66.03 9.26 33 97980 1567 90528867
Erythema 65.79 9.26 449 97564 228797 90301637
Colitis 65.38 9.26 195 97818 69747 90460687
Creatinine renal clearance increased 65.35 9.26 42 97971 3239 90527195
Seizure 63.81 9.26 330 97683 152299 90378135
Cognitive disorder 63.45 9.26 192 97821 69215 90461219
COVID-19 63.10 9.26 354 97659 168489 90361945
Product dose omission issue 62.79 9.26 534 97479 291153 90239281
Sleep disorder 62.70 9.26 73 97940 197957 90332477
Incorrect drug administration rate 60.37 9.26 48 97965 5175 90525259
Anaesthetic complication neurological 58.39 9.26 24 97989 717 90529717
Headache 58.03 9.26 1279 96734 861467 89668967
Obesity 57.60 9.26 21 97992 105486 90424948
Fibromyalgia 57.13 9.26 84 97929 206185 90324249
Grip strength decreased 56.68 9.26 15 97998 92561 90437873
Renal function test abnormal 56.50 9.26 53 97960 7138 90523296
Pulse absent 56.18 9.26 49 97964 6006 90524428
Sulphaemoglobinaemia 55.08 9.26 21 97992 512 90529922
Emotional distress 53.69 9.26 121 97892 36541 90493893
Drug hypersensitivity 53.39 9.26 289 97724 463320 90067114
Abdominal pain upper 53.23 9.26 183 97830 332491 90197943
Discomfort 53.19 9.26 138 97875 274197 90256237
Product use issue 53.12 9.26 181 97832 329738 90200696
Extradural haematoma 52.74 9.26 31 97982 2037 90528397
Confusional state 52.45 9.26 227 97786 385978 90144456
Systemic toxicity 52.02 9.26 17 97996 259 90530175
Liver disorder 51.30 9.26 34 97979 121235 90409199
Condition aggravated 50.55 9.26 407 97606 595138 89935296
Deep vein thrombosis postoperative 50.53 9.26 8 98005 70801 90459633
Drug ineffective for unapproved indication 48.86 9.26 171 97842 66473 90463961
Product adhesion issue 48.49 9.26 42 97971 5100 90525334
Arthralgia 48.43 9.26 574 97439 777948 89752486
Apnoea 47.97 9.26 55 97958 9359 90521075
Unresponsive to stimuli 47.35 9.26 118 97895 38003 90492431
Infusion site urticaria 47.17 9.26 27 97986 1688 90528746
Pulmonary fibrosis 47.03 9.26 29 97984 107474 90422960
Adjustment disorder with depressed mood 46.47 9.26 4 98009 56749 90473685
Seasonal allergy 45.62 9.26 86 97927 22897 90507537
Extradural abscess 45.44 9.26 24 97989 1280 90529154
Upper respiratory tract infection 45.28 9.26 265 97748 128053 90402381
Anterior chamber cell 45.28 9.26 20 97993 716 90529718
Balance disorder 44.88 9.26 216 97797 96864 90433570
Ventricular fibrillation 44.70 9.26 65 97948 13979 90516455
Prescribed overdose 44.60 9.26 25 97988 97600 90432834
Joint range of motion decreased 44.01 9.26 49 97964 135594 90394840
Haematochezia 43.66 9.26 172 97841 70741 90459693
C-reactive protein increased 43.59 9.26 81 97932 181308 90349126
Staphylococcal infection 43.34 9.26 133 97880 48306 90482128
Inappropriate schedule of product administration 43.19 9.26 294 97719 149639 90380795
Fear 43.15 9.26 70 97943 16552 90513882
Rectal haemorrhage 42.60 9.26 190 97823 82554 90447880
Prescribed underdose 42.56 9.26 14 97999 75005 90455429
Musculoskeletal pain 42.47 9.26 75 97938 171176 90359258
Ventricular tachycardia 41.26 9.26 86 97927 24622 90505812
Peripheral swelling 40.95 9.26 270 97743 412836 90117598
Mental status changes 40.27 9.26 123 97890 44556 90485878
Product formulation issue 40.22 9.26 18 97995 665 90529769
Hip arthroplasty 40.21 9.26 16 97997 76192 90454242
Lagophthalmos 39.63 9.26 16 97997 456 90529978
Lung disorder 39.61 9.26 63 97950 149820 90380614
Bronchitis 39.46 9.26 292 97721 152635 90377799
Wheezing 39.41 9.26 129 97884 237951 90292483
Hypercholesterolaemia 39.13 9.26 31 97982 100861 90429573
Night sweats 39.12 9.26 49 97964 128717 90401717
Peripheral nerve injury 38.86 9.26 18 97995 721 90529713
Infusion site mass 38.68 9.26 26 97987 2163 90528271
Knee arthroplasty 38.43 9.26 21 97992 83161 90447273
Hypopyon 38.16 9.26 19 97994 895 90529539
Blepharospasm 37.94 9.26 7 98006 55438 90474996
Respiratory tract infection 37.76 9.26 145 97868 58933 90471501
Tachycardia 37.30 9.26 295 97718 157378 90373056
Bursitis infective 36.85 9.26 22 97991 1488 90528946
Administration site pain 36.17 9.26 20 97993 1169 90529265
Wound infection 36.12 9.26 37 97976 106365 90424069
Endophthalmitis 35.80 9.26 34 97979 4651 90525783
Localised infection 35.65 9.26 98 97915 33464 90496970
Nail disorder 35.35 9.26 10 98003 59057 90471377
Type I hypersensitivity 35.32 9.26 32 97981 4123 90526311
Spinal epidural haemorrhage 35.26 9.26 13 98000 288 90530146
Embolia cutis medicamentosa 34.87 9.26 16 97997 627 90529807
Spinal epidural haematoma 34.03 9.26 20 97993 1314 90529120
Osteoarthritis 33.83 9.26 104 97909 195626 90334808
Bone erosion 33.60 9.26 8 98005 53013 90477421
Frequent bowel movements 33.37 9.26 136 97877 56799 90473635
Rash 33.22 9.26 634 97379 795466 89734968
Status epilepticus 33.06 9.26 67 97946 18807 90511627
Gastrointestinal disorder 32.94 9.26 154 97859 256533 90273901
Pneumocephalus 32.93 9.26 12 98001 257 90530177
Multiple drug therapy 32.47 9.26 39 97974 6970 90523464
Corneal epithelium defect 32.34 9.26 14 97999 477 90529957
Bronchospasm 32.18 9.26 70 97943 20639 90509795
Unevaluable event 32.14 9.26 131 97882 54717 90475717
Kidney infection 31.95 9.26 80 97933 25836 90504598
Bundle branch block left 31.91 9.26 41 97972 7844 90522590
Chills 31.80 9.26 248 97765 131733 90398701
Weight increased 31.67 9.26 294 97719 417633 90112801
Infusion site discharge 31.67 9.26 24 97989 2411 90528023
Dry mouth 31.66 9.26 98 97915 183961 90346473
Nausea 31.03 9.26 1482 96531 1108834 89421600
Sinus tachycardia 31.03 9.26 84 97929 28429 90502005
Colitis ulcerative 30.73 9.26 138 97875 60128 90470306
Renal injury 30.58 9.26 46 97967 10197 90520237
Autoimmune disorder 30.50 9.26 23 97990 76721 90453713
Haemorrhoids 30.41 9.26 80 97933 26622 90503812
Lupus vulgaris 30.17 9.26 6 98007 45053 90485381
Drug-induced liver injury 29.99 9.26 32 97981 90286 90440148
Stridor 29.63 9.26 31 97982 4762 90525672
Vascular malformation 29.54 9.26 15 97998 737 90529697
Adverse event 29.49 9.26 51 97962 117367 90413067
Anhedonia 29.48 9.26 48 97965 11383 90519051
Loss of personal independence in daily activities 29.10 9.26 65 97948 136040 90394394
Infusion site rash 29.08 9.26 23 97990 2460 90527974
Ophthalmoplegia 29.06 9.26 20 97993 1729 90528705
Red blood cell sedimentation rate increased 28.86 9.26 28 97985 82567 90447867
Paranasal cyst 28.48 9.26 15 97998 795 90529639
Cauda equina syndrome 28.47 9.26 18 97995 1349 90529085
Paraplegia 28.46 9.26 26 97987 3386 90527048
Meningitis chemical 28.34 9.26 11 98002 282 90530152
Neurotoxicity 28.30 9.26 68 97945 21399 90509035
Vitritis 28.11 9.26 19 97994 1595 90528839
Premature delivery 28.01 9.26 99 97914 38663 90491771
Anal skin tags 27.99 9.26 14 97999 666 90529768
Hepatic cirrhosis 27.75 9.26 17 97996 63236 90467198
Parophthalmia 27.66 9.26 12 98001 411 90530023
Epidural haemorrhage 27.60 9.26 11 98002 303 90530131
Back pain 27.52 9.26 489 97524 316686 90213748
Fear of eating 27.42 9.26 12 98001 420 90530014
Purtscher retinopathy 27.31 9.26 9 98004 141 90530293
Onychomadesis 27.14 9.26 8 98005 45990 90484444
Tenderness 27.11 9.26 77 97936 26791 90503643
Hepatitis 27.10 9.26 22 97991 70717 90459717
Infusion site nodule 26.98 9.26 19 97994 1704 90528730
Respiratory depression 26.94 9.26 55 97958 15520 90514914
Eye pain 26.28 9.26 106 97907 44062 90486372
Skin infection 26.20 9.26 59 97954 17805 90512629
Stress 26.10 9.26 164 97849 81231 90449203
Ear infection 25.85 9.26 146 97867 69629 90460805
Cellulitis 25.64 9.26 178 97835 91159 90439275
Myelosuppression 25.54 9.26 13 98000 53578 90476856
Platelet aggregation inhibition 25.27 9.26 9 98004 180 90530254
Hypoxia 25.19 9.26 149 97864 72250 90458184
Skin warm 25.08 9.26 36 97977 7651 90522783
Aqueous fibrin 24.91 9.26 8 98005 115 90530319
Eyelid ptosis 24.85 9.26 39 97974 8967 90521467
Eye irritation 24.74 9.26 87 97926 33891 90496543
Administration site swelling 24.57 9.26 17 97996 1482 90528952
Photophobia 24.50 9.26 64 97949 21205 90509229
Psoriasis 24.48 9.26 80 97933 147674 90382760
Multiple allergies 24.46 9.26 52 97961 15094 90515340
Underdose 24.43 9.26 14 97999 54003 90476431
Product use in unapproved indication 24.26 9.26 504 97509 335732 90194702
Septic arthritis staphylococcal 24.10 9.26 12 98001 565 90529869
Retinitis 23.98 9.26 6 98007 38452 90491982
Spinal cord compression 23.86 9.26 28 97985 4883 90525551
Medical device site cellulitis 23.70 9.26 9 98004 217 90530217
Product preparation error 23.68 9.26 41 97972 10220 90520214
Trigeminal palsy 23.67 9.26 7 98006 75 90530359
Vitamin D increased 23.65 9.26 14 97999 932 90529502
Visual acuity reduced 23.53 9.26 67 97946 23343 90507091
Foreign body sensation in eyes 23.43 9.26 23 97990 3277 90527157
Body tinea 23.25 9.26 19 97994 2129 90528305
Diplopia 23.09 9.26 76 97937 28638 90501796
Otitis media 22.94 9.26 30 97983 5840 90524594
Post procedural complication 22.66 9.26 58 97955 18984 90511450
Epidural analgesia 22.32 9.26 8 98005 163 90530271
Lower limb fracture 22.20 9.26 36 97977 84977 90445457
Procedure aborted 22.10 9.26 8 98005 168 90530266
Therapy partial responder 22.07 9.26 63 97950 21980 90508454
Weight decreased 21.96 9.26 552 97461 379358 90151076
Retinal vasculitis 21.86 9.26 16 97997 1525 90528909
Infusion site discomfort 21.66 9.26 17 97996 1799 90528635
Ejection fraction decreased 21.57 9.26 70 97943 26183 90504251
C-reactive protein 21.38 9.26 4 98009 31363 90499071
Foetal heart rate abnormal 20.87 9.26 13 98000 949 90529485
Superinfection 20.82 9.26 21 97992 3091 90527343
Mastoiditis 20.71 9.26 16 97997 1654 90528780
Medical device site abscess 20.69 9.26 8 98005 203 90530231
Gastroenteritis viral 20.64 9.26 76 97937 30279 90500155
Punctate keratitis 20.48 9.26 12 98001 784 90529650
Retinal artery occlusion 20.31 9.26 18 97995 2253 90528181
Liver function test increased 20.28 9.26 38 97975 84817 90445617
Upper airway obstruction 20.03 9.26 13 98000 1019 90529415
Neuromuscular block prolonged 19.93 9.26 11 98002 641 90529793
Procedural complication 19.87 9.26 28 97985 5850 90524584
Infection 19.82 9.26 274 97739 361820 90168614
Back injury 19.81 9.26 13 98000 46609 90483825
Overdose 19.80 9.26 259 97754 157450 90372984
Nerve root injury 19.75 9.26 6 98007 71 90530363
Poor venous access 19.74 9.26 56 97957 19471 90510963
Sciatica 19.63 9.26 51 97962 101331 90429103
Memory impairment 19.47 9.26 129 97884 197115 90333319
Intentional self-injury 19.45 9.26 4 98009 29330 90501104
Proctalgia 19.24 9.26 33 97980 8165 90522269
Foetal exposure during delivery 19.19 9.26 9 98004 371 90530063
Hepatotoxicity 19.18 9.26 13 98000 45829 90484605
Atonic urinary bladder 19.16 9.26 7 98006 151 90530283
Infusion site warmth 18.96 9.26 17 97996 2161 90528273
Ventricular hypokinesia 18.89 9.26 26 97987 5315 90525119
Spinal anaesthesia 18.83 9.26 6 98007 84 90530350
Transferrin decreased 18.79 9.26 9 98004 389 90530045
Airway peak pressure increased 18.37 9.26 9 98004 409 90530025
Nephrolithiasis 18.37 9.26 103 97910 48982 90481452
Arthritis 18.29 9.26 106 97907 167209 90363225
Coeliac disease 18.20 9.26 13 98000 44597 90485837
Incorrect route of product administration 18.14 9.26 105 97908 50521 90479913
Cardiogenic shock 18.12 9.26 63 97950 24405 90506029
Abortion spontaneous 18.11 9.26 19 97994 54037 90476397
Injection site alopecia 18.00 9.26 5 98008 42 90530392
Product distribution issue 17.80 9.26 21 97992 3684 90526750
Viral infection 17.61 9.26 90 97923 41324 90489110
Thyroid atrophy 17.57 9.26 8 98005 308 90530126
Arthritis bacterial 17.51 9.26 30 97983 7415 90523019
Ventricular extrasystoles 17.50 9.26 42 97971 13208 90517226
Hyperthermia malignant 17.34 9.26 13 98000 1285 90529149
Road traffic accident 17.32 9.26 59 97954 107567 90422867
Vision blurred 17.30 9.26 189 97824 110104 90420330
Nerve block 17.05 9.26 11 98002 854 90529580
Vasoplegia syndrome 17.04 9.26 18 97995 2796 90527638
Infusion site discolouration 17.03 9.26 12 98001 1077 90529357
Thrombocytopenia 17.03 9.26 144 97869 208581 90321853
Hypoaesthesia oral 17.02 9.26 46 97967 15554 90514880
Suicide attempt 16.95 9.26 35 97978 75364 90455070
Apnoeic attack 16.94 9.26 8 98005 335 90530099
Meningitis aseptic 16.87 9.26 28 97985 6745 90523689
Nystagmus 16.84 9.26 29 97984 7198 90523236
Circulatory collapse 16.63 9.26 62 97951 24842 90505592
Vocal cord dysfunction 16.49 9.26 11 98002 903 90529531
Onychomycosis 16.46 9.26 10 98003 37366 90493068
Economic problem 16.43 9.26 19 97994 3262 90527172
Monoplegia 16.30 9.26 20 97993 3654 90526780
Vascular stenosis 16.26 9.26 9 98004 527 90529907
Fall 16.23 9.26 656 97357 481154 90049280
Nail bed tenderness 16.20 9.26 8 98005 370 90530064
Heliotrope rash 16.18 9.26 7 98006 238 90530196
Taste disorder 16.13 9.26 26 97987 61520 90468914
Dysphoria 16.09 9.26 26 97987 6128 90524306
Depression 15.90 9.26 229 97784 300372 90230062
Anxiety 15.85 9.26 443 97570 309329 90221105
Loss of consciousness 15.84 9.26 226 97787 140012 90390422
Tinnitus 15.84 9.26 90 97923 43012 90487422
Paralysis 15.83 9.26 37 97976 11441 90518993
Drug interaction 15.76 9.26 401 97612 276052 90254382
Pulmonary oedema 15.70 9.26 118 97895 61962 90468472
Leukopenia 15.68 9.26 56 97957 100654 90429780
Eye infarction 15.50 9.26 5 98008 73 90530361
Cardio-respiratory arrest 15.40 9.26 119 97894 63021 90467413
Drug ineffective 15.39 9.26 1715 96298 1382583 89147851
Spinal synovial cyst 15.31 9.26 5 98008 76 90530358
Haemodynamic instability 15.28 9.26 37 97976 11702 90518732
Obstruction 15.26 9.26 20 97993 3901 90526533
Left ventricle outflow tract obstruction 15.19 9.26 8 98005 424 90530010
Anaphylactoid shock 15.09 9.26 8 98005 430 90530004
Inadequate analgesia 15.03 9.26 18 97995 3206 90527228
Drug tolerance decreased 15.00 9.26 8 98005 32122 90498312
Pancreatitis acute 14.99 9.26 8 98005 32107 90498327
Walking aid user 14.95 9.26 10 98003 35496 90494938
Mouth swelling 14.91 9.26 24 97989 5638 90524796
Hypertensive emergency 14.90 9.26 15 97998 2202 90528232
Electrocardiogram ST segment elevation 14.89 9.26 20 97993 3996 90526438
Product administration interrupted 14.81 9.26 38 97975 12454 90517980
Respiratory distress 14.76 9.26 82 97931 38864 90491570
Iron binding capacity total decreased 14.62 9.26 8 98005 458 90529976
Maternal exposure during pregnancy 14.58 9.26 288 97725 359775 90170659
Pain 14.50 9.26 1258 96755 995083 89535351
Scleral hyperaemia 14.48 9.26 7 98006 309 90530125
Poikiloderma 14.44 9.26 7 98006 311 90530123
Wrong product administered 14.37 9.26 28 97985 7637 90522797
Gastrooesophageal reflux disease 14.37 9.26 113 97900 166224 90364210
Oral herpes 14.35 9.26 73 97940 33451 90496983
Intercepted medication error 14.30 9.26 10 98003 887 90529547
Cough 14.24 9.26 510 97503 368452 90161982
Impaired quality of life 14.13 9.26 56 97957 23088 90507346
Retinal detachment 14.13 9.26 26 97987 6796 90523638
Allergy to immunoglobulin therapy 14.07 9.26 6 98007 197 90530237
Streptococcal infection 14.01 9.26 27 97986 7306 90523128
Foot deformity 14.00 9.26 27 97986 59624 90470810
Blood pressure decreased 13.97 9.26 133 97880 74762 90455672
Anal sphincter atony 13.93 9.26 7 98006 336 90530098
Eyelid contusion 13.90 9.26 5 98008 103 90530331
Product administration error 13.84 9.26 61 97952 26362 90504072
Apgar score low 13.78 9.26 11 98002 1192 90529242
Brain stem syndrome 13.76 9.26 9 98004 715 90529719
Infection susceptibility increased 13.72 9.26 19 97994 3907 90526527
Anaemia 13.69 9.26 488 97525 352314 90178120
Inhibitory drug interaction 13.68 9.26 17 97996 3146 90527288
Conjunctival oedema 13.61 9.26 10 98003 959 90529475
Glucose tolerance impaired 13.57 9.26 28 97985 7957 90522477
Administration site extravasation 13.57 9.26 11 98002 1219 90529215
Arthritis infective 13.56 9.26 28 97985 7964 90522470
Orbital infection 13.51 9.26 5 98008 112 90530322
Vaginal abscess 13.50 9.26 8 98005 534 90529900
Cerebral congestion 13.43 9.26 5 98008 114 90530320
Exostosis 13.41 9.26 23 97990 53111 90477323
Lupus-like syndrome 13.41 9.26 20 97993 48826 90481608
Foetal death 13.38 9.26 3 98010 20720 90509714
Heparin-induced thrombocytopenia 13.29 9.26 22 97991 5290 90525144
Mydriasis 13.22 9.26 41 97972 14971 90515463
Cystitis 13.21 9.26 120 97893 66598 90463836
Blood pressure abnormal 13.20 9.26 49 97964 19596 90510838
Quadriparesis 13.17 9.26 15 97998 2534 90527900
Neonatal toxicity 13.11 9.26 4 98009 48 90530386
Asthenia 13.11 9.26 459 97554 533292 89997142
Neuralgia 13.07 9.26 68 97945 31432 90499002
Delayed recovery from anaesthesia 13.06 9.26 10 98003 1020 90529414
Axillary nerve injury 13.04 9.26 4 98009 49 90530385
Influenza like illness 13.04 9.26 139 97874 80472 90449962
Labelled drug-drug interaction medication error 13.00 9.26 40 97973 14542 90515892
Infusion site streaking 12.91 9.26 8 98005 579 90529855
Liver function test abnormal 12.84 9.26 22 97991 50823 90479611
Skin discolouration 12.81 9.26 87 97926 44228 90486206
Sinusitis bacterial 12.79 9.26 13 98000 1930 90528504
Anterior chamber fibrin 12.78 9.26 5 98008 131 90530303
Body dysmorphic disorder 12.74 9.26 7 98006 404 90530030
Lethargy 12.72 9.26 114 97899 63025 90467409
Peripheral vascular disorder 12.68 9.26 24 97989 6407 90524027
Infusion site scar 12.67 9.26 8 98005 598 90529836
Anorectal discomfort 12.63 9.26 16 97997 3018 90527416
Laboratory test abnormal 12.63 9.26 16 97997 41838 90488596
Epilepsy 12.60 9.26 46 97967 82160 90448274
Immunodeficiency 12.56 9.26 17 97996 43217 90487217
Vascular resistance systemic decreased 12.54 9.26 5 98008 138 90530296
Injection site atrophy 12.51 9.26 9 98004 835 90529599
Implant site bruising 12.51 9.26 7 98006 419 90530015
Calcinosis 12.49 9.26 15 97998 2680 90527754
Fibula agenesis 12.49 9.26 4 98009 57 90530377
Ocular hypertension 12.47 9.26 12 98001 1668 90528766
Nasopharyngitis 12.45 9.26 340 97673 406764 90123670
Abdominal pain 12.45 9.26 535 97478 395186 90135248
Post procedural infection 12.43 9.26 33 97980 11041 90519393
Spina bifida occulta 12.42 9.26 4 98009 58 90530376
Hepatocellular injury 12.40 9.26 8 98005 28950 90501484
Procedural anxiety 12.40 9.26 9 98004 847 90529587
Duodenal stenosis 12.39 9.26 8 98005 622 90529812
Spinal stroke 12.24 9.26 4 98009 61 90530373
Intraocular pressure increased 12.21 9.26 25 97988 7068 90523366
Akinesia 12.14 9.26 12 98001 1724 90528710
Aphonia 12.13 9.26 35 97978 12284 90518150
Gastric mucosa erythema 12.09 9.26 7 98006 447 90529987
Physical disability 12.06 9.26 18 97995 3963 90526471
Skin test positive 11.99 9.26 9 98004 891 90529543
Administration site erythema 11.91 9.26 9 98004 900 90529534
Cancer pain 11.91 9.26 18 97995 4007 90526427
Arthritis fungal 11.89 9.26 4 98009 67 90530367
Infusion site oedema 11.86 9.26 10 98003 1171 90529263
Anaphylactoid reaction 11.85 9.26 19 97994 4449 90525985
Macular oedema 11.84 9.26 20 97993 4889 90525545
Tremor 11.82 9.26 232 97781 152941 90377493
Nail bed inflammation 11.77 9.26 12 98001 1789 90528645
Instillation site pain 11.73 9.26 9 98004 921 90529513
Amnesia 11.72 9.26 69 97944 108436 90421998
Pustule 11.68 9.26 15 97998 2868 90527566
Finger deformity 11.67 9.26 11 98002 32886 90497548
Swelling face 11.67 9.26 137 97876 81215 90449219
Hypoaesthesia 11.63 9.26 255 97758 313955 90216479
Electrocardiogram QRS complex prolonged 11.60 9.26 25 97988 7323 90523111
Intraocular pressure fluctuation 11.57 9.26 4 98009 73 90530361
Eclampsia 11.49 9.26 7 98006 491 90529943
Product administered at inappropriate site 11.49 9.26 18 97995 4133 90526301
Trigemino-cardiac reflex 11.47 9.26 4 98009 75 90530359
Agitation 11.47 9.26 117 97896 66981 90463453
Bacterial infection 11.44 9.26 53 97960 23391 90507043
Dermatitis 11.41 9.26 51 97962 22169 90508265
Dermatitis atopic 11.40 9.26 53 97960 23419 90507015
Insomnia 11.40 9.26 274 97739 333200 90197234
Neutropenia 11.31 9.26 173 97840 224731 90305703
Quadriplegia 11.31 9.26 13 98000 2218 90528216
Papule 11.26 9.26 26 97987 7976 90522458
Sensory loss 11.25 9.26 44 97969 18031 90512403
Cholestasis of pregnancy 11.21 9.26 11 98002 1566 90528868
Oral pain 11.20 9.26 67 97946 32616 90497818
Intentional product use issue 11.20 9.26 166 97847 216726 90313708
Fear-related avoidance of activities 11.14 9.26 5 98008 186 90530248
Seronegative arthritis 11.07 9.26 3 98010 18231 90512203
Appetite disorder 11.05 9.26 28 97985 9105 90521329
Venous injury 11.05 9.26 8 98005 750 90529684
Drug resistance 11.02 9.26 10 98003 30439 90499995
Pneumonia mycoplasmal 10.98 9.26 9 98004 1013 90529421
Device expulsion 10.97 9.26 17 97996 40869 90489565
Phrenic nerve paralysis 10.96 9.26 6 98007 344 90530090
Corneal abrasion 10.92 9.26 10 98003 1306 90529128
Haematocrit increased 10.91 9.26 15 97998 3063 90527371
Orbital oedema 10.89 9.26 6 98007 348 90530086
Accelerated idioventricular rhythm 10.88 9.26 4 98009 88 90530346
Allergy to metals 10.84 9.26 9 98004 1031 90529403
Metapneumovirus infection 10.80 9.26 10 98003 1325 90529109
Haemangioma congenital 10.78 9.26 7 98006 549 90529885
Pseudomonas infection 10.77 9.26 38 97975 14827 90515607
Ischaemia 10.74 9.26 20 97993 5275 90525159
Infusion site injury 10.71 9.26 4 98009 92 90530342
Infusion site irritation 10.68 9.26 10 98003 1343 90529091
Tryptase increased 10.66 9.26 7 98006 560 90529874
Application site alopecia 10.61 9.26 3 98010 27 90530407
Implant site swelling 10.60 9.26 7 98006 565 90529869
Genital ulceration 10.60 9.26 9 98004 1064 90529370
Dysuria 10.59 9.26 76 97937 39325 90491109
Vanishing bile duct syndrome 10.56 9.26 10 98003 1362 90529072
Repetitive strain injury 10.53 9.26 5 98008 212 90530222
Retinal cyst 10.51 9.26 4 98009 97 90530337
Mean arterial pressure decreased 10.51 9.26 5 98008 213 90530221
Inappropriate antidiuretic hormone secretion 10.45 9.26 4 98009 19501 90510933
Off label use 10.41 9.26 1352 96661 1100900 89429534
Respiratory failure 10.40 9.26 183 97830 118235 90412199
Ocular procedural complication 10.37 9.26 6 98007 383 90530051
Drug reaction with eosinophilia and systemic symptoms 10.35 9.26 19 97994 42739 90487695
Spinal cord injury 10.34 9.26 9 98004 1100 90529334
Conduction disorder 10.33 9.26 11 98002 1724 90528710
Glomerulonephritis acute 10.29 9.26 4 98009 103 90530331
Rectosigmoid cancer metastatic 10.24 9.26 3 98010 31 90530403
Laryngitis 10.23 9.26 25 97988 50728 90479706
Autonomic neuropathy 10.23 9.26 10 98003 1417 90529017
Haemorrhagic vasculitis 10.22 9.26 4 98009 105 90530329
Allergic cough 10.21 9.26 9 98004 1119 90529315
Injury 10.20 9.26 151 97862 197198 90333236
Normal newborn 10.09 9.26 51 97962 23311 90507123
Coccygectomy 10.07 9.26 3 98010 33 90530401
Sympathectomy 10.07 9.26 3 98010 33 90530401
Speech disorder 10.07 9.26 84 97929 45501 90484933
Acute respiratory failure 9.97 9.26 80 97933 42838 90487596
Diplegia 9.95 9.26 10 98003 1465 90528969
Product contamination 9.83 9.26 9 98004 1175 90529259
Limb injury 9.80 9.26 63 97950 31445 90498989
Nasal mucosal disorder 9.72 9.26 11 98002 1846 90528588
Infusion related hypersensitivity reaction 9.68 9.26 7 98006 655 90529779
Hallucination, tactile 9.66 9.26 6 98007 436 90529998
Infusion related reaction 9.64 9.26 361 97652 416419 90114015
Incision site rash 9.62 9.26 3 98010 39 90530395
Supraventricular extrasystoles 9.61 9.26 19 97994 5238 90525196
Central pain syndrome 9.60 9.26 7 98006 663 90529771
Device ineffective 9.60 9.26 5 98008 259 90530175
Death of relative 9.58 9.26 6 98007 442 90529992
Tumour pain 9.57 9.26 11 98002 1876 90528558
Retinal haemorrhage 9.55 9.26 20 97993 5744 90524690
Pancreatitis 9.48 9.26 41 97972 69785 90460649
Device infusion issue 9.48 9.26 13 98000 2649 90527785
Oropharyngeal pain 9.41 9.26 176 97837 115011 90415423
Hordeolum 9.37 9.26 18 97995 4860 90525574
Septic shock 9.37 9.26 53 97960 84107 90446327
Poor quality sleep 9.36 9.26 52 97961 24641 90505793
Anorgasmia 9.33 9.26 7 98006 693 90529741
Joint stiffness 9.32 9.26 48 97965 77994 90452440
Ocular discomfort 9.30 9.26 21 97992 6349 90524085
Renal cyst 9.29 9.26 33 97980 12917 90517517
Immobilisation syndrome 9.28 9.26 6 98007 467 90529967

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 489.81 10.60 163 55999 2137 42563036
Anaphylactic shock 198.60 10.60 197 55965 23320 42541853
Methaemoglobinaemia 191.54 10.60 110 56052 5664 42559509
Anaphylactic reaction 183.75 10.60 253 55909 42490 42522683
Inspiratory capacity decreased 159.43 10.60 78 56084 2889 42562284
Hypertrichosis 145.96 10.60 47 56115 551 42564622
Product formulation issue 132.49 10.60 47 56115 754 42564419
Anaesthetic complication 114.93 10.60 50 56112 1407 42563766
Cardiac arrest 114.21 10.60 360 55802 108960 42456213
Fear 98.42 10.60 95 56067 10870 42554303
Toxic anterior segment syndrome 96.94 10.60 44 56118 1372 42563801
Hypotension 93.62 10.60 620 55542 257011 42308162
Injury 91.24 10.60 129 56033 22187 42542986
Emotional distress 85.84 10.60 106 56056 15987 42549186
Toxicity to various agents 80.52 10.60 547 55615 228589 42336584
Ventricular tachycardia 78.66 10.60 142 56020 30018 42535155
Anhedonia 73.91 10.60 69 56093 7571 42557602
Bradycardia 69.48 10.60 259 55903 85225 42479948
Renal injury 64.07 10.60 80 56082 12200 42552973
Ventricular fibrillation 63.99 10.60 130 56032 29993 42535180
Generalised tonic-clonic seizure 63.51 10.60 120 56042 26259 42538914
Electrocardiogram ST segment elevation 58.15 10.60 54 56108 5885 42559288
Ocular procedural complication 54.30 10.60 13 56149 43 42565130
Tachycardia 54.14 10.60 270 55892 100817 42464356
Pericardial effusion 52.56 10.60 118 56044 29157 42536016
Drug ineffective 51.22 10.60 1136 55026 629061 41936112
Interstitial lung disease 47.40 10.60 22 56140 78440 42486733
Unresponsive to stimuli 46.04 10.60 117 56045 31286 42533887
Sinusitis 45.03 10.60 151 56011 47141 42518032
Overdose 43.47 10.60 262 55900 105002 42460171
Drug ineffective for unapproved indication 42.72 10.60 146 56016 46017 42519156
Incorrect route of product administration 41.45 10.60 96 56066 24209 42540964
Anal inflammation 40.35 10.60 29 56133 2200 42562973
Infusion site extravasation 39.17 10.60 42 56120 5439 42559734
Disease progression 38.80 10.60 82 56080 143574 42421599
Infusion site pain 37.96 10.60 41 56121 5354 42559819
Adulterated product 37.78 10.60 19 56143 747 42564426
Spinal cord infarction 37.26 10.60 18 56144 648 42564525
Accident 36.57 10.60 44 56118 6459 42558714
Pain 35.98 10.60 486 55676 244362 42320811
Stress 35.93 10.60 134 56028 44078 42521095
Hyperthermia malignant 35.81 10.60 29 56133 2629 42562544
Insurance issue 35.69 10.60 35 56127 4081 42561092
SARS-CoV-2 test negative 34.22 10.60 24 56138 1751 42563422
Trigemino-cardiac reflex 33.46 10.60 14 56148 357 42564816
Unevaluable event 33.10 10.60 110 56052 34178 42530995
Accidental overdose 32.99 10.60 97 56065 28233 42536940
Diarrhoea 32.35 10.60 421 55741 460428 42104745
Proctalgia 31.98 10.60 43 56119 7050 42558123
Infusion site erythema 31.78 10.60 31 56131 3591 42561582
Ear infection 31.75 10.60 59 56103 12745 42552428
Haemorrhoids 30.78 10.60 69 56093 17028 42548145
Cauda equina syndrome 30.72 10.60 18 56144 962 42564211
Sinus tachycardia 30.32 10.60 77 56085 20576 42544597
Status epilepticus 28.19 10.60 63 56099 15515 42549658
Electrocardiogram QRS complex prolonged 27.33 10.60 36 56126 5787 42559386
Cardiogenic shock 27.29 10.60 106 56056 35534 42529639
Oculocardiac reflex 27.17 10.60 9 56153 116 42565057
Anaesthetic complication neurological 27.05 10.60 15 56147 721 42564452
Tracheitis 24.71 10.60 16 56146 1023 42564150
Product label on wrong product 24.58 10.60 7 56155 52 42565121
Blood phosphorus increased 24.19 10.60 52 56110 12473 42552700
Acute kidney injury 24.13 10.60 340 55822 366997 42198176
Haemodynamic instability 24.10 10.60 52 56110 12505 42552668
Hypoxia 24.06 10.60 166 55996 69620 42495553
Respiratory tract infection bacterial 23.98 10.60 20 56142 1889 42563284
Tubulointerstitial nephritis 23.97 10.60 6 56156 31542 42533631
Injection related reaction 23.87 10.60 13 56149 603 42564570
Negative pressure pulmonary oedema 23.69 10.60 13 56149 612 42564561
Product adhesion issue 23.48 10.60 19 56143 1720 42563453
Myelosuppression 23.44 10.60 12 56150 40449 42524724
Suicide attempt 23.42 10.60 16 56146 46084 42519089
Bronchospasm 23.19 10.60 52 56110 12833 42552340
Infusion site swelling 23.13 10.60 25 56137 3267 42561906
Cardiac tamponade 22.68 10.60 35 56127 6505 42558668
Rheumatoid arthritis 22.55 10.60 14 56148 42426 42522747
Mydriasis 22.48 10.60 41 56121 8729 42556444
Leukopenia 22.48 10.60 40 56122 74706 42490467
Blindness 22.32 10.60 63 56099 17915 42547258
Mixed anxiety and depressive disorder 21.35 10.60 9 56153 234 42564939
Laryngospasm 21.27 10.60 19 56143 1969 42563204
Neurotoxicity 21.17 10.60 74 56088 23577 42541596
Chemical burn 21.15 10.60 10 56152 343 42564830
Corneal oedema 21.09 10.60 17 56145 1531 42563642
Kounis syndrome 20.95 10.60 24 56138 3344 42561829
Apnoea 20.67 10.60 37 56125 7766 42557407
Respiratory depression 20.45 10.60 63 56099 18805 42546368
Vasoplegia syndrome 20.14 10.60 21 56141 2634 42562539
Brain stem syndrome 20.08 10.60 12 56150 665 42564508
Seizure 20.07 10.60 245 55917 120316 42444857
Brain oedema 20.06 10.60 57 56105 16270 42548903
Respiratory tract infection 19.91 10.60 78 56084 26244 42538929
Renal cyst haemorrhage 19.87 10.60 12 56150 678 42564495
Decreased appetite 19.86 10.60 161 56001 192976 42372197
Thrombocytopenia 19.85 10.60 158 56004 190121 42375052
Swelling 19.78 10.60 132 56030 54753 42510420
Cytomegalovirus infection 19.59 10.60 9 56153 32297 42532876
Neuralgia 19.40 10.60 76 56086 25571 42539602
Anxiety 19.33 10.60 240 55922 118320 42446853
Rectal prolapse 19.31 10.60 11 56151 557 42564616
Diabetes insipidus 19.06 10.60 24 56138 3689 42561484
Intracranial hypotension 18.83 10.60 10 56152 441 42564732
Postoperative delirium 18.75 10.60 11 56151 589 42564584
Lagophthalmos 18.59 10.60 7 56155 134 42565039
Hyperphosphataemia 18.59 10.60 48 56114 12956 42552217
Myasthenia gravis 18.54 10.60 55 56107 16082 42549091
Prostate cancer 18.37 10.60 19 56143 44624 42520549
Neuromuscular blockade 18.18 10.60 9 56153 342 42564831
Embolia cutis medicamentosa 18.11 10.60 9 56153 345 42564828
Type I hypersensitivity 18.01 10.60 18 56144 2148 42563025
Aqueous fibrin 18.00 10.60 6 56156 79 42565094
Drug interaction 17.91 10.60 246 55916 266753 42298420
Agranulocytosis 17.85 10.60 9 56153 30603 42534570
Retinal artery occlusion 17.67 10.60 18 56144 2197 42562976
Mental status changes 17.47 10.60 105 56057 42010 42523163
Respiratory tract infection viral 17.46 10.60 22 56140 3384 42561789
Loss of consciousness 17.29 10.60 192 55970 92162 42473011
Weight decreased 17.21 10.60 183 55979 207765 42357408
Vascular compression 17.20 10.60 9 56153 385 42564788
Seizure like phenomena 17.00 10.60 13 56149 1084 42564089
Pneumocystis jirovecii pneumonia 16.93 10.60 6 56156 25175 42539998
Dermatitis contact 16.89 10.60 25 56137 4478 42560695
Reperfusion arrhythmia 16.87 10.60 6 56156 97 42565076
Pulmonary fibrosis 16.87 10.60 7 56155 26674 42538499
Myoclonus 16.69 10.60 55 56107 17010 42548163
Vitreous floaters 16.62 10.60 24 56138 4206 42560967
Drug therapy 16.58 10.60 30 56132 6350 42558823
Macular ischaemia 16.57 10.60 7 56155 183 42564990
Appendicolith 16.56 10.60 47 56115 13409 42551764
Spinal meningeal cyst 16.54 10.60 6 56156 103 42565070
Swelling of eyelid 16.44 10.60 17 56145 2111 42563062
Infusion site bruising 16.35 10.60 12 56150 940 42564233
Electrocardiogram ST-T segment depression 16.32 10.60 4 56158 15 42565158
Circulatory collapse 16.26 10.60 68 56094 23568 42541605
Vascular anastomotic haemorrhage 16.13 10.60 8 56154 305 42564868
Analgesic therapy 16.10 10.60 30 56132 6494 42558679
Endophthalmitis 15.76 10.60 24 56138 4409 42560764
Tryptase increased 15.73 10.60 8 56154 322 42564851
Ventricular extrasystoles 15.73 10.60 46 56116 13344 42551829
Paraesthesia oral 15.67 10.60 26 56136 5137 42560036
Kidney congestion 15.65 10.60 9 56153 464 42564709
Administration site pain 15.64 10.60 9 56153 465 42564708
Oesophageal injury 15.61 10.60 7 56155 212 42564961
Post procedural complication 15.51 10.60 44 56118 12546 42552627
Respiratory acidosis 15.48 10.60 29 56133 6302 42558871
Thyrotoxic crisis 15.44 10.60 11 56151 823 42564350
Rhabdomyolysis 15.39 10.60 52 56110 77967 42487206
Corneal opacity 15.22 10.60 10 56152 655 42564518
Chorioretinopathy 15.14 10.60 14 56148 1517 42563656
Body temperature increased 15.14 10.60 60 56102 20298 42544875
General physical health deterioration 15.12 10.60 127 56035 151119 42414054
Finger amputation 15.05 10.60 7 56155 231 42564942
Sleep disorder therapy 14.93 10.60 30 56132 6864 42558309
Ceruloplasmin increased 14.78 10.60 4 56158 24 42565149
Drug resistance 14.75 10.60 14 56148 34234 42530939
Catecholamine crisis 14.72 10.60 5 56157 70 42565103
Loss of personal independence in daily activities 14.67 10.60 27 56135 49789 42515384
Wrong product administered 14.58 10.60 28 56134 6198 42558975
Haematochezia 14.42 10.60 35 56127 58401 42506772
Hypertension 14.25 10.60 304 55858 166900 42398273
Enterobacter pneumonia 14.23 10.60 9 56153 552 42564621
Open globe injury 14.22 10.60 5 56157 78 42565095
Death 14.10 10.60 494 55668 470691 42094482
Asthma 14.09 10.60 39 56123 62275 42502898
Anal sphincter atony 14.02 10.60 6 56156 162 42565011
Blood copper increased 14.01 10.60 4 56158 30 42565143
Neutropenia 13.99 10.60 182 55980 199249 42365924
Iron deficiency 13.97 10.60 39 56123 11022 42554151
Vitreous disorder 13.95 10.60 6 56156 164 42565009
Appendicitis 13.94 10.60 59 56103 20554 42544619
Corneal epithelium defect 13.89 10.60 8 56154 414 42564759
Respiratory arrest 13.86 10.60 74 56088 28350 42536823
Procedural hypotension 13.63 10.60 11 56151 992 42564181
Ventricular asystole 13.51 10.60 7 56155 293 42564880
Pulmonary oedema 13.51 10.60 118 56044 53154 42512019
Application site pain 13.49 10.60 16 56146 2313 42562860
Restlessness 13.49 10.60 75 56087 29174 42535999
Atrioventricular block complete 13.31 10.60 39 56123 11325 42553848
Behaviour disorder 13.30 10.60 29 56133 7025 42558148
Melaena 13.28 10.60 19 56143 38727 42526446
Encephalomalacia 13.09 10.60 11 56151 1050 42564123
Pancreatitis acute 13.02 10.60 15 56147 33549 42531624
Hyperaesthesia 13.01 10.60 26 56136 5926 42559247
Accidental exposure to product by child 12.99 10.60 13 56149 1554 42563619
Electrocardiogram T wave amplitude increased 12.98 10.60 5 56157 102 42565071
Pulseless electrical activity 12.95 10.60 32 56130 8405 42556768
Hypoxic-ischaemic encephalopathy 12.93 10.60 24 56138 5178 42559995
Phaeochromocytoma crisis 12.89 10.60 5 56157 104 42565069
Sinus bradycardia 12.89 10.60 46 56116 14807 42550366
Foetal exposure during pregnancy 12.76 10.60 27 56135 47284 42517889
Penile oedema 12.72 10.60 8 56154 486 42564687
Pleuropericarditis 12.63 10.60 7 56155 336 42564837
Blood 25-hydroxycholecalciferol decreased 12.63 10.60 7 56155 336 42564837
Vena cava injury 12.61 10.60 7 56155 337 42564836
Fatigue 12.51 10.60 459 55703 435182 42129991
Abdominal wall haemorrhage 12.37 10.60 8 56154 510 42564663
Myokymia 12.35 10.60 5 56157 117 42565056
Procedural pain 12.34 10.60 25 56137 5754 42559419
Lip haemorrhage 12.31 10.60 10 56152 910 42564263
Periorbital oedema 12.23 10.60 22 56140 4635 42560538
Delayed recovery from anaesthesia 12.17 10.60 11 56151 1158 42564015
Bacteroides infection 12.15 10.60 16 56146 2571 42562602
Infusion site pruritus 12.13 10.60 11 56151 1162 42564011
Foreign body sensation in eyes 11.99 10.60 10 56152 945 42564228
Hypophosphataemia 11.95 10.60 57 56105 20888 42544285
Activated partial thromboplastin time prolonged 11.93 10.60 47 56115 15856 42549317
Pulse absent 11.91 10.60 26 56136 6301 42558872
Disability 11.88 10.60 25 56137 5908 42559265
White blood cell count decreased 11.81 10.60 91 56071 110305 42454868
Rash 11.64 10.60 277 55885 276677 42288496
Erythema of eyelid 11.60 10.60 12 56150 1491 42563682
Anaemia 11.59 10.60 281 55881 279997 42285176
Torsade de pointes 11.55 10.60 31 56131 8563 42556610
Wrong route 11.54 10.60 3 56159 15 42565158
Illness 11.54 10.60 64 56098 24866 42540307
Mean arterial pressure increased 11.52 10.60 4 56158 60 42565113
Postictal state 11.41 10.60 10 56152 1010 42564163
Skin hyperpigmentation 11.30 10.60 20 56142 4161 42561012
Oesophageal obstruction 11.28 10.60 8 56154 594 42564579
Hyperparathyroidism secondary 11.25 10.60 13 56149 1829 42563344
Blindness transient 11.21 10.60 16 56146 2773 42562400
Abdominal discomfort 11.18 10.60 56 56106 75199 42489974
Cardiotoxicity 11.18 10.60 28 56134 7417 42557756
Transient ischaemic attack 11.12 10.60 17 56145 33722 42531451
Nightmare 11.04 10.60 10 56152 25002 42540171
Myocardial necrosis 11.02 10.60 6 56156 278 42564895
Hepatocellular injury 11.02 10.60 9 56153 23669 42541504
Lung opacity 11.01 10.60 24 56138 5813 42559360
Scrotal oedema 10.92 10.60 13 56149 1886 42563287
Blood uric acid increased 10.90 10.60 45 56117 15502 42549671
Brain hypoxia 10.88 10.60 8 56154 629 42564544
Foreign body in eye 10.75 10.60 5 56157 165 42565008
Peripheral nerve decompression 10.69 10.60 3 56159 21 42565152
Induration 10.69 10.60 10 56152 1100 42564073
Hypoaesthesia oral 10.61 10.60 21 56141 4752 42560421

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 1271.14 9.22 402 126848 5135 110456914
Anaphylactic reaction 438.49 9.22 597 126653 113703 110348346
Anaphylactic shock 419.41 9.22 398 126852 51148 110410901
Cardiac arrest 339.21 9.22 719 126531 196034 110266015
Hypotension 313.20 9.22 1312 125938 522537 109939512
Toxic anterior segment syndrome 296.36 9.22 121 127129 3333 110458716
Methaemoglobinaemia 272.17 9.22 155 127095 9013 110453036
Maternal exposure during delivery 265.85 9.22 113 127137 3452 110458597
Synovitis 264.52 9.22 12 127238 274080 110187969
Hypertrichosis 260.23 9.22 92 127158 1686 110460363
Hand deformity 216.08 9.22 8 127242 218498 110243551
Anaesthetic complication 209.76 9.22 96 127154 3510 110458539
Toxicity to various agents 204.52 9.22 1091 126159 479464 109982585
Systemic lupus erythematosus 196.89 9.22 29 127221 254309 110207740
Paraesthesia oral 195.74 9.22 217 127033 33454 110428595
Helicobacter infection 193.71 9.22 3 127247 181874 110280175
Pemphigus 190.09 9.22 15 127235 214555 110247494
Anti-cyclic citrullinated peptide antibody positive 182.25 9.22 6 127244 181978 110280071
Hepatic enzyme increased 179.88 9.22 72 127178 320820 110141229
Sedation complication 178.25 9.22 162 127088 19693 110442356
Joint swelling 175.41 9.22 151 127099 442694 110019355
Glossodynia 174.90 9.22 24 127226 221980 110240069
Macular degeneration 173.78 9.22 166 127084 21493 110440556
Chronic sinusitis 167.54 9.22 174 127076 24910 110437139
Duodenal ulcer perforation 167.51 9.22 9 127241 177691 110284358
Product formulation issue 165.17 9.22 61 127189 1273 110460776
Pericarditis 165.00 9.22 27 127223 219087 110242962
Procedural pain 156.76 9.22 199 127051 35366 110426683
Generalised tonic-clonic seizure 155.21 9.22 248 127002 54432 110407617
Kounis syndrome 154.26 9.22 92 127158 5833 110456216
Arthropathy 149.31 9.22 72 127178 287450 110174599
Contraindicated product administered 148.75 9.22 50 127200 248217 110213832
Bradycardia 146.99 9.22 453 126797 155064 110306985
Inspiratory capacity decreased 144.42 9.22 67 127183 2528 110459521
Creatinine renal clearance decreased 139.76 9.22 148 127102 21667 110440382
Folliculitis 139.72 9.22 15 127235 167638 110294411
Vaginal flatulence 139.30 9.22 114 127136 12030 110450019
Fear 139.18 9.22 152 127098 23041 110439008
Female genital tract fistula 131.37 9.22 126 127124 16393 110445656
Radiculopathy 127.11 9.22 133 127117 19203 110442846
Type 2 diabetes mellitus 126.59 9.22 25 127225 177207 110284842
General physical health deterioration 123.80 9.22 186 127064 425109 110036940
Rheumatoid factor positive 123.03 9.22 7 127243 131633 110330416
Muscle injury 121.52 9.22 11 127239 140796 110321253
Emotional distress 119.93 9.22 198 127052 44649 110417400
Proctitis 119.53 9.22 121 127129 16806 110445243
Rheumatic fever 116.17 9.22 6 127244 122573 110339476
Vaginal discharge 113.84 9.22 121 127129 17787 110444262
Ventricular tachycardia 113.08 9.22 205 127045 49804 110412245
Liver injury 112.19 9.22 19 127231 150394 110311655
Blood calcium decreased 112.08 9.22 170 127080 35675 110426374
Ventricular fibrillation 111.29 9.22 183 127067 41130 110420919
Therapeutic product effect decreased 108.52 9.22 74 127176 244242 110217807
Wound 108.21 9.22 68 127182 234369 110227680
Psoriatic arthropathy 105.64 9.22 47 127203 196714 110265335
Constipation 104.86 9.22 738 126512 357048 110105001
Impaired healing 102.49 9.22 49 127201 196668 110265381
Depressed level of consciousness 102.32 9.22 323 126927 111955 110350094
Unresponsive to stimuli 101.65 9.22 226 127024 63564 110398485
Renal injury 99.24 9.22 115 127135 18598 110443451
Stress cardiomyopathy 99.07 9.22 106 127144 15700 110446349
Anaesthetic complication neurological 98.33 9.22 39 127211 994 110461055
Facet joint syndrome 97.62 9.22 3 127247 96825 110365224
C-reactive protein abnormal 97.58 9.22 16 127234 129679 110332370
Abdominal discomfort 97.43 9.22 191 127059 393667 110068382
Drug intolerance 96.42 9.22 202 127048 406310 110055739
Anhedonia 92.38 9.22 101 127149 15327 110446722
Rheumatoid arthritis 92.12 9.22 126 127124 299487 110162562
Irritable bowel syndrome 91.71 9.22 37 127213 164178 110297871
Seizure 91.71 9.22 499 126751 220686 110241363
Tachycardia 91.08 9.22 507 126743 226138 110235911
Pulseless electrical activity 88.89 9.22 103 127147 16654 110445395
Drug ineffective for unapproved indication 88.40 9.22 290 126960 102548 110359501
Sleep disorder due to general medical condition, insomnia type 86.63 9.22 10 127240 105633 110356416
Ill-defined disorder 84.93 9.22 37 127213 156816 110305233
Dermatitis contact 84.69 9.22 92 127158 13861 110448188
Bursitis 83.50 9.22 23 127227 129895 110332154
Corneal oedema 81.90 9.22 49 127201 3124 110458925
Unevaluable event 80.33 9.22 197 127053 59030 110403019
Alopecia 79.33 9.22 190 127060 364563 110097486
Lip dry 78.37 9.22 11 127239 100072 110361977
Procedural hypotension 76.10 9.22 43 127207 2462 110459587
Inflammation 73.88 9.22 68 127182 193170 110268879
Swollen joint count increased 73.65 9.22 6 127244 83655 110378394
Insurance issue 71.56 9.22 74 127176 10538 110451511
Peripheral venous disease 71.44 9.22 7 127243 84110 110377939
Oral candidiasis 69.54 9.22 157 127093 44603 110417446
Obesity 69.32 9.22 22 127228 113329 110348720
Overdose 67.12 9.22 480 126770 233314 110228735
Status epilepticus 67.07 9.22 126 127124 31445 110430604
Musculoskeletal stiffness 66.35 9.22 139 127111 279683 110182366
Arthralgia 64.97 9.22 579 126671 779053 109682996
Sinus tachycardia 64.65 9.22 152 127098 44341 110417708
Hypercholesterolaemia 62.41 9.22 14 127236 90823 110371226
Haemorrhoids 60.95 9.22 130 127120 35542 110426507
Gait inability 60.95 9.22 41 127209 136335 110325714
Myelosuppression 60.07 9.22 17 127233 94323 110367726
Fibromyalgia 59.77 9.22 65 127185 170844 110291205
Apnoea 59.60 9.22 76 127174 13563 110448486
Pulse absent 59.21 9.22 69 127181 11223 110450826
Creatinine renal clearance increased 59.18 9.22 42 127208 3583 110458466
Incorrect route of product administration 59.00 9.22 185 127065 63876 110398173
Product adhesion issue 58.95 9.22 39 127211 2967 110459082
Drug ineffective 58.62 9.22 2218 125032 1518322 108943727
Cauda equina syndrome 57.99 9.22 34 127216 2088 110459961
Bronchospasm 57.30 9.22 115 127135 30124 110431925
Erythema 57.14 9.22 549 126701 290898 110171151
Orthostatic hypotension 57.08 9.22 187 127063 66062 110395987
Completed suicide 56.12 9.22 122 127128 242259 110219790
Abdominal pain upper 55.64 9.22 210 127040 348901 110113148
Liver disorder 55.63 9.22 49 127201 142194 110319855
Lagophthalmos 55.42 9.22 22 127228 562 110461487
Pulmonary fibrosis 55.35 9.22 24 127226 102018 110360031
Mental status changes 55.27 9.22 203 127047 75919 110386130
Sedation 55.02 9.22 191 127059 69492 110392557
Infusion site bruising 53.93 9.22 40 127210 3654 110458395
Infusion site pain 53.58 9.22 82 127168 17337 110444712
Electrocardiogram ST segment elevation 53.17 9.22 59 127191 9101 110452948
Hyperthermia malignant 52.00 9.22 40 127210 3860 110458189
Sulphaemoglobinaemia 51.58 9.22 21 127229 574 110461475
Stress 51.53 9.22 249 127001 105099 110356950
Endophthalmitis 51.47 9.22 55 127195 8132 110453917
Blister 51.37 9.22 116 127134 227260 110234789
Infusion site erythema 51.25 9.22 66 127184 11893 110450156
Infusion site swelling 51.20 9.22 60 127190 9817 110452232
Lower respiratory tract infection 50.97 9.22 129 127121 242977 110219072
Embolia cutis medicamentosa 50.92 9.22 24 127226 939 110461110
Cardiogenic shock 50.44 9.22 163 127087 57175 110404874
Grip strength decreased 50.03 9.22 15 127235 80159 110381890
Urinary tract infection 49.18 9.22 583 126667 325699 110136350
Proctalgia 49.04 9.22 68 127182 13154 110448895
C-reactive protein increased 47.76 9.22 113 127137 217806 110244243
Deep vein thrombosis postoperative 47.65 9.22 6 127244 59285 110402764
Cognitive disorder 47.32 9.22 213 127037 87298 110374751
Hypopyon 47.24 9.22 26 127224 1414 110460635
Accidental overdose 47.09 9.22 149 127101 51685 110410364
Ocular procedural complication 47.06 9.22 19 127231 508 110461541
Neurotoxicity 46.59 9.22 130 127120 42077 110419972
Lung disorder 46.50 9.22 85 127165 179962 110282087
Joint range of motion decreased 46.41 9.22 43 127207 121789 110340260
Extradural abscess 46.34 9.22 29 127221 2005 110460044
Type I hypersensitivity 45.69 9.22 46 127204 6347 110455702
Osteoarthritis 45.60 9.22 88 127162 182535 110279514
Trigemino-cardiac reflex 45.60 9.22 18 127232 453 110461596
Anterior chamber cell 45.52 9.22 24 127226 1197 110460852
Spinal cord infarction 45.00 9.22 23 127227 1075 110460974
Condition aggravated 44.58 9.22 587 126663 734249 109727800
Hypoxia 43.80 9.22 277 126973 129238 110332811
Extradural haematoma 43.71 9.22 34 127216 3335 110458714
Gastrointestinal disorder 43.63 9.22 138 127112 241814 110220235
Corneal epithelium defect 42.97 9.22 21 127229 891 110461158
Systemic toxicity 42.79 9.22 16 127234 346 110461703
Renal function test abnormal 42.53 9.22 52 127198 8894 110453155
Rash 42.39 9.22 677 126573 820287 109641762
Illness 42.20 9.22 197 127053 81974 110380075
Peripheral swelling 42.06 9.22 282 126968 403752 110058297
Pericardial effusion 41.89 9.22 153 127097 57064 110404985
Respiratory depression 41.87 9.22 105 127145 31896 110430153
Swelling 41.75 9.22 235 127015 350806 110111243
Nail disorder 41.72 9.22 8 127242 57927 110404122
Loss of consciousness 41.57 9.22 376 126874 195930 110266119
Anal inflammation 40.93 9.22 29 127221 2467 110459582
Stomatitis 40.85 9.22 166 127084 270076 110191973
Infusion site extravasation 40.43 9.22 58 127192 11576 110450473
Blood cholesterol increased 40.34 9.22 96 127154 184689 110277360
Musculoskeletal pain 39.23 9.22 96 127154 182927 110279122
Aqueous fibrin 38.81 9.22 13 127237 201 110461848
Haemodynamic instability 38.62 9.22 83 127167 22805 110439244
Hypersensitivity 38.62 9.22 289 126961 403709 110058340
Blepharospasm 38.60 9.22 8 127242 54843 110407206
Underdose 37.69 9.22 13 127237 63541 110398508
Suicide attempt 37.63 9.22 38 127212 103356 110358693
Lower limb fracture 37.38 9.22 20 127230 75328 110386721
Wheezing 37.19 9.22 159 127091 255071 110206978
Pain 37.10 9.22 1395 125855 953560 109508489
Electrocardiogram QRS complex prolonged 36.86 9.22 59 127191 12962 110449087
Retinal artery occlusion 36.83 9.22 34 127216 4215 110457834
Adverse event 36.27 9.22 43 127207 108766 110353283
Ophthalmoplegia 35.92 9.22 31 127219 3519 110458530
Arthritis 35.84 9.22 88 127162 167498 110294551
Pulmonary oedema 35.73 9.22 218 127032 100441 110361608
Infusion site pruritus 35.72 9.22 36 127214 4972 110457077
Red blood cell sedimentation rate increased 35.71 9.22 23 127227 78279 110383770
Peripheral nerve injury 35.67 9.22 20 127230 1128 110460921
Premature delivery 35.45 9.22 96 127154 30536 110431513
Post procedural complication 35.43 9.22 88 127162 26570 110435479
Treatment failure 34.94 9.22 182 127068 277052 110184997
Vitritis 34.91 9.22 27 127223 2626 110459423
Weight increased 34.72 9.22 312 126938 419332 110042717
Prescribed overdose 34.44 9.22 30 127220 87551 110374498
Paraplegia 34.39 9.22 39 127211 6161 110455888
Retinal vasculitis 34.05 9.22 24 127226 2025 110460024
Hepatitis 34.04 9.22 32 127218 90022 110372027
Nasopharyngitis 34.04 9.22 290 126960 394071 110067978
Night sweats 33.93 9.22 64 127186 133919 110328130
Fear of eating 33.70 9.22 15 127235 513 110461536
Onychomadesis 33.53 9.22 6 127244 45657 110416392
Wound infection 33.37 9.22 37 127213 96428 110365621
Coeliac disease 33.22 9.22 5 127245 43182 110418867
Drug hypersensitivity 33.19 9.22 348 126902 453742 110008307
Product preparation error 33.16 9.22 51 127199 10828 110451221
SARS-CoV-2 test negative 32.98 9.22 24 127226 2129 110459920
Adulterated product 32.87 9.22 19 127231 1136 110460913
Colitis 32.85 9.22 216 127034 102107 110359942
Infusion site haemorrhage 32.70 9.22 33 127217 4565 110457484
Loss of personal independence in daily activities 32.69 9.22 78 127172 149942 110312107
Multiple drug therapy 32.43 9.22 43 127207 7971 110454078
Product use issue 32.20 9.22 218 127032 311477 110150572
Diarrhoea 32.16 9.22 1033 126217 1138472 109323577
Balance disorder 32.09 9.22 237 127013 116323 110345726
Meningitis chemical 31.87 9.22 13 127237 357 110461692
Vasoplegia syndrome 31.51 9.22 35 127215 5404 110456645
Brain oedema 30.67 9.22 92 127158 31006 110431043
Circulatory collapse 30.66 9.22 114 127136 42879 110419170
Intentional product use issue 30.54 9.22 164 127086 247742 110214307
Respiratory tract infection bacterial 30.52 9.22 24 127226 2392 110459657
Vascular malformation 30.35 9.22 16 127234 798 110461251
Prescribed underdose 29.92 9.22 19 127231 65155 110396894
Psoriasis 29.55 9.22 74 127176 139919 110322130
Spinal epidural haemorrhage 29.54 9.22 12 127238 326 110461723
Hypoaesthesia oral 29.09 9.22 62 127188 16940 110445109
Hip arthroplasty 28.91 9.22 14 127236 55799 110406250
Visual acuity reduced 28.78 9.22 92 127158 32081 110429968
Sleep disorder 28.78 9.22 124 127126 198520 110263529
Wrong product administered 28.77 9.22 48 127202 10912 110451137
Paranasal cyst 28.77 9.22 16 127234 888 110461161
Postoperative delirium 28.59 9.22 16 127234 899 110461150
Seasonal allergy 28.24 9.22 67 127183 19655 110442394
Spinal epidural haematoma 28.19 9.22 20 127230 1705 110460344
Nystagmus 28.15 9.22 49 127201 11528 110450521
Tryptase increased 28.14 9.22 16 127234 927 110461122
Drug-induced liver injury 28.14 9.22 60 127190 120007 110342042
Oculocardiac reflex 27.96 9.22 9 127241 122 110461927
Incorrect drug administration rate 27.79 9.22 33 127217 5475 110456574
Anal sphincter atony 27.74 9.22 13 127237 502 110461547
Foreign body sensation in eyes 27.59 9.22 26 127224 3308 110458741
Injection related reaction 27.43 9.22 19 127231 1559 110460490
Blood phosphorus increased 27.28 9.22 59 127191 16281 110445768
Ventricular extrasystoles 27.25 9.22 72 127178 22569 110439480
COVID-19 27.04 9.22 414 126836 244646 110217403
Neuralgia 26.96 9.22 119 127131 48359 110413690
Hepatic cirrhosis 26.79 9.22 23 127227 67603 110394446
Leukopenia 26.72 9.22 85 127165 148706 110313343
Eye irritation 26.67 9.22 92 127158 33360 110428689
Lupus-like syndrome 26.62 9.22 7 127243 40785 110421264
Thrombocytopenia 26.45 9.22 265 126985 348620 110113429
Stridor 26.38 9.22 36 127214 6859 110455190
Purtscher retinopathy 26.38 9.22 10 127240 225 110461824
Confusional state 26.36 9.22 380 126870 468300 109993749
Mydriasis 26.20 9.22 70 127180 22087 110439962
Tenderness 26.17 9.22 84 127166 29353 110432696
Tracheitis 25.94 9.22 19 127231 1702 110460347
Infusion site mass 25.88 9.22 19 127231 1709 110460340
Knee arthroplasty 25.84 9.22 22 127228 64926 110397123
Delayed recovery from anaesthesia 25.84 9.22 21 127229 2194 110459855
Paralysis 25.67 9.22 56 127194 15544 110446505
Otitis media 25.58 9.22 37 127213 7439 110454610
Appendicolith 25.57 9.22 53 127197 14202 110447847
Anxiety 25.38 9.22 547 126703 344531 110117518
Asthma 25.37 9.22 176 127074 250115 110211934
Foot deformity 25.35 9.22 12 127238 48468 110413581
Chorioretinopathy 25.19 9.22 21 127229 2274 110459775
Product label on wrong product 25.18 9.22 7 127243 55 110461994
Pneumocephalus 25.07 9.22 12 127238 486 110461563
Multiple organ dysfunction syndrome 25.04 9.22 276 126974 151434 110310615
Upper respiratory tract infection 25.03 9.22 246 127004 131082 110330967
Accident 24.88 9.22 45 127205 10907 110451142
Analgesic therapy 24.86 9.22 36 127214 7248 110454801
Drug therapy 24.83 9.22 36 127214 7255 110454794
Respiratory tract infection 24.72 9.22 154 127096 71463 110390586
Diabetes insipidus 24.68 9.22 34 127216 6536 110455513
Economic problem 24.65 9.22 27 127223 4104 110457945
Decreased appetite 24.64 9.22 392 126858 475454 109986595
Product dose omission issue 24.62 9.22 513 126737 321269 110140780
Hepatotoxicity 24.59 9.22 22 127228 63378 110398671
Sleep disorder therapy 24.16 9.22 36 127214 7435 110454614
Asthenia 24.11 9.22 606 126644 688393 109773656
Epidural haemorrhage 24.04 9.22 11 127239 402 110461647
Neuromuscular block prolonged 24.02 9.22 16 127234 1231 110460818
Negative pressure pulmonary oedema 23.98 9.22 13 127237 686 110461363
Myoclonus 23.95 9.22 88 127162 32910 110429139
Infection 23.91 9.22 284 126966 361916 110100133
Autoimmune disorder 23.90 9.22 24 127226 65459 110396590
Bursitis infective 23.86 9.22 17 127233 1459 110460590
Back pain 23.84 9.22 577 126673 370419 110091630
Hyperphosphataemia 23.83 9.22 56 127194 16325 110445724
Platelet aggregation inhibition 23.80 9.22 9 127241 201 110461848
Cardiotoxicity 23.79 9.22 57 127193 16824 110445225
Procedural complication 23.68 9.22 38 127212 8367 110453682
Infusion related reaction 23.60 9.22 303 126947 380859 110081190
Fatigue 23.29 9.22 1153 126097 1214805 109247244
Pancreatitis acute 23.28 9.22 21 127229 60253 110401796
Trigeminal palsy 23.24 9.22 7 127243 75 110461974
Neuromuscular blockade 23.22 9.22 13 127237 731 110461318
Chemical burn 23.16 9.22 13 127237 735 110461314
Upper airway obstruction 22.98 9.22 18 127232 1784 110460265
Medical device site cellulitis 22.97 9.22 9 127241 222 110461827
Mastoiditis 22.84 9.22 21 127229 2590 110459459
Onychomycosis 22.64 9.22 8 127242 38523 110423526
Cardiac tamponade 22.63 9.22 44 127206 11263 110450786
Myasthenia gravis 22.52 9.22 65 127185 21446 110440603
Body tinea 22.48 9.22 19 127231 2096 110459953
Memory impairment 22.24 9.22 134 127116 196810 110265239
Cytomegalovirus infection 22.21 9.22 18 127232 54426 110407623
Punctate keratitis 22.12 9.22 15 127235 1189 110460860
Tubulointerstitial nephritis 22.07 9.22 18 127232 54266 110407783
Restlessness 22.00 9.22 125 127125 56134 110405915
Infusion site urticaria 21.98 9.22 15 127235 1201 110460848
Epidural analgesia 21.75 9.22 8 127242 165 110461884
Foetal heart rate abnormal 21.63 9.22 12 127238 663 110461386
Procedure aborted 21.40 9.22 8 127242 173 110461876
Acute kidney injury 21.39 9.22 562 126688 634868 109827181
Parophthalmia 21.31 9.22 11 127239 525 110461524
Blood pressure decreased 21.16 9.22 214 127036 114877 110347172
Cholestasis 20.97 9.22 26 127224 64492 110397557
Sciatica 20.97 9.22 47 127203 92352 110369697
Staphylococcal infection 20.86 9.22 145 127105 69799 110392250
Disease progression 20.80 9.22 180 127070 243854 110218195
Blindness 20.79 9.22 90 127160 36269 110425780
Eye pain 20.71 9.22 113 127137 49986 110412063
Rectal haemorrhage 20.70 9.22 220 127030 119613 110342436
Brain stem syndrome 20.68 9.22 15 127235 1324 110460725
Febrile neutropenia 20.45 9.22 493 126757 316274 110145775
Spinal anaesthesia 20.34 9.22 7 127243 118 110461931
Hepatocellular injury 20.34 9.22 17 127233 50625 110411424
Renal cyst haemorrhage 20.29 9.22 12 127238 749 110461300
Exostosis 20.28 9.22 14 127236 45942 110416107
Hypertensive crisis 20.28 9.22 68 127182 24304 110437745
Shock 20.26 9.22 118 127132 53470 110408579
Pneumocystis jirovecii pneumonia 20.25 9.22 12 127238 42723 110419326
Medical device site abscess 20.24 9.22 8 127242 202 110461847
Back injury 20.18 9.22 15 127235 47384 110414665
Bundle branch block left 19.79 9.22 45 127205 12843 110449206
Nerve root injury 19.78 9.22 6 127244 66 110461983
Spinal cord compression 19.73 9.22 33 127217 7519 110454530
Product administration error 19.68 9.22 90 127160 37127 110424922
Taste disorder 19.57 9.22 28 127222 65359 110396690
Infusion site discharge 19.50 9.22 17 127233 1956 110460093
Airway peak pressure increased 19.40 9.22 11 127239 634 110461415
Mean arterial pressure decreased 19.30 9.22 10 127240 481 110461568
Macular ischaemia 19.17 9.22 8 127242 233 110461816
Therapy partial responder 19.13 9.22 89 127161 36972 110425077
Drug resistance 19.09 9.22 22 127228 56352 110405697
Multiple allergies 19.03 9.22 43 127207 12220 110449829
Interstitial lung disease 18.96 9.22 89 127161 139245 110322804
Epilepsy 18.87 9.22 56 127194 100153 110361896
Injection site reaction 18.86 9.22 47 127203 89023 110373026
Laryngospasm 18.82 9.22 25 127225 4643 110457406
Respiratory acidosis 18.75 9.22 46 127204 13780 110448269
Respiratory arrest 18.67 9.22 123 127127 58176 110403873
Inadequate analgesia 18.66 9.22 26 127224 5051 110456998
Product contamination microbial 18.61 9.22 13 127237 1081 110460968
Kidney congestion 18.60 9.22 10 127240 519 110461530
Intentional self-injury 18.47 9.22 10 127240 37419 110424630
Frequent bowel movements 18.43 9.22 143 127107 71247 110390802
Sinus bradycardia 18.43 9.22 75 127175 29408 110432641
Atonic urinary bladder 18.40 9.22 7 127243 159 110461890
C-reactive protein 18.34 9.22 6 127244 30325 110431724
Liver function test abnormal 18.29 9.22 32 127218 68918 110393131
Hypophosphataemia 18.11 9.22 81 127169 33101 110428948
Photophobia 18.09 9.22 68 127182 25703 110436346
Blood copper increased 18.01 9.22 5 127245 39 110462010
Eyelid ptosis 17.72 9.22 44 127206 13283 110448766
Neutropenia 17.62 9.22 314 126936 374306 110087743
Skin test positive 17.46 9.22 14 127236 1435 110460614
Vision blurred 17.45 9.22 226 127024 128796 110333253
Vascular compression 17.45 9.22 11 127239 770 110461279
Activated partial thromboplastin time prolonged 17.38 9.22 61 127189 22307 110439742
Thyroid atrophy 17.31 9.22 8 127242 299 110461750
Vascular anastomotic haemorrhage 17.17 9.22 8 127242 305 110461744
Bone marrow failure 17.09 9.22 25 127225 57823 110404226
Corneal opacity 17.05 9.22 13 127237 1238 110460811
Diplopia 16.99 9.22 94 127156 41800 110420249
Hyperaesthesia 16.89 9.22 46 127204 14681 110447368
Gastroenteritis viral 16.87 9.22 76 127174 31150 110430899
Intracranial hypotension 16.85 9.22 10 127240 628 110461421
Appendicitis 16.69 9.22 71 127179 28393 110433656
Metastases to liver 16.68 9.22 10 127240 35376 110426673
Chills 16.64 9.22 310 126940 190270 110271779
Depression 16.55 9.22 261 126989 317074 110144975
Quadriplegia 16.48 9.22 22 127228 4105 110457944
Dry mouth 16.37 9.22 149 127101 199799 110262250
Drug reaction with eosinophilia and systemic symptoms 16.10 9.22 45 127205 82050 110379999
Discomfort 15.88 9.22 164 127086 214543 110247506
Spinal meningeal cyst 15.87 9.22 6 127244 134 110461915
Atrioventricular block complete 15.81 9.22 55 127195 20027 110442022
Cyanosis 15.78 9.22 72 127178 29669 110432380
Respiratory tract infection viral 15.78 9.22 26 127224 5852 110456197
Abortion spontaneous 15.73 9.22 10 127240 34272 110427777
Cardio-respiratory arrest 15.71 9.22 203 127047 115633 110346416
Anterior chamber fibrin 15.63 9.22 7 127243 243 110461806
Nail bed tenderness 15.61 9.22 8 127242 376 110461673
Vocal cord dysfunction 15.49 9.22 11 127239 939 110461110
Pleural effusion 15.49 9.22 289 126961 177420 110284629
Heparin-induced thrombocytopenia 15.49 9.22 38 127212 11386 110450663
Skin infection 15.48 9.22 59 127191 22450 110439599
Vitreous disorder 15.48 9.22 8 127242 383 110461666
Lip haemorrhage 15.34 9.22 13 127237 1439 110460610
Anal skin tags 15.30 9.22 9 127241 556 110461493
Skin warm 15.18 9.22 33 127217 9137 110452912
Electrocardiogram ST-T segment depression 15.18 9.22 4 127246 25 110462024
Behaviour disorder 15.16 9.22 34 127216 9613 110452436
Injection site joint infection 15.13 9.22 5 127245 74 110461975
Anaphylactoid shock 15.12 9.22 11 127239 975 110461074
Ceruloplasmin increased 14.92 9.22 4 127246 27 110462022
Hypoxic-ischaemic encephalopathy 14.83 9.22 32 127218 8815 110453234
Swelling of eyelid 14.69 9.22 27 127223 6626 110455423
Product administered at inappropriate site 14.67 9.22 24 127226 5369 110456680
Seizure like phenomena 14.65 9.22 16 127234 2425 110459624
Apnoeic attack 14.64 9.22 10 127240 802 110461247
Infusion site discomfort 14.58 9.22 14 127236 1823 110460226
Thrombosis 14.56 9.22 190 127060 108472 110353577
Torsade de pointes 14.53 9.22 58 127192 22542 110439507
Anaesthetic complication pulmonary 14.47 9.22 6 127244 172 110461877
Lethargy 14.42 9.22 168 127082 93408 110368641
Colitis ulcerative 14.29 9.22 144 127106 77219 110384830
Physical disability 14.27 9.22 23 127227 5083 110456966
Neuroleptic malignant syndrome 14.22 9.22 11 127239 34048 110428001
Vitamin D increased 14.19 9.22 10 127240 843 110461206
Product distribution issue 14.14 9.22 21 127229 4325 110457724
Oesophageal injury 14.13 9.22 7 127243 306 110461743
Drug tolerance decreased 14.12 9.22 7 127243 27533 110434516
Reperfusion arrhythmia 14.11 9.22 7 127243 307 110461742
Respiratory distress 14.10 9.22 131 127119 68743 110393306
Rhabdomyolysis 14.08 9.22 81 127169 120320 110341729
Finger amputation 13.99 9.22 10 127240 863 110461186
Mouth swelling 13.97 9.22 28 127222 7326 110454723
Catecholamine crisis 13.93 9.22 5 127245 96 110461953
Diabetic foot infection 13.87 9.22 10 127240 874 110461175
Spinal cord injury 13.81 9.22 13 127237 1652 110460397
Application site alopecia 13.81 9.22 4 127246 37 110462012
Miosis 13.81 9.22 56 127194 21927 110440122
Vaginal abscess 13.74 9.22 8 127242 485 110461564
Insomnia 13.73 9.22 313 126937 360277 110101772
Airway complication of anaesthesia 13.72 9.22 9 127241 675 110461374
Scrotal oedema 13.70 9.22 13 127237 1668 110460381
Blood uric acid increased 13.64 9.22 55 127195 21474 110440575
Agitation 13.64 9.22 194 127056 112857 110349192
Implant site bruising 13.60 9.22 7 127243 332 110461717
Hypertensive emergency 13.59 9.22 18 127232 3333 110458716
Respiratory failure 13.54 9.22 334 126916 214998 110247051
Obstruction 13.54 9.22 24 127226 5728 110456321
Eyelid contusion 13.51 9.22 5 127245 105 110461944
Deafness permanent 13.41 9.22 10 127240 921 110461128
Vena cava injury 13.35 9.22 7 127243 345 110461704
Progressive multifocal leukoencephalopathy 13.32 9.22 6 127244 24950 110437099
Familial periodic paralysis 13.22 9.22 7 127243 352 110461697
Induration 13.20 9.22 15 127235 2374 110459675
Iron deficiency 13.18 9.22 49 127201 18427 110443622
Ventricular tachyarrhythmia 13.16 9.22 8 127242 525 110461524
Electrocardiogram ST segment depression 13.13 9.22 23 127227 5438 110456611
Drug level increased 13.11 9.22 97 127153 47622 110414427
Retinal detachment 13.06 9.22 35 127215 11065 110450984
Left ventricle outflow tract obstruction 13.02 9.22 8 127242 535 110461514
Application site pain 13.01 9.22 23 127227 5476 110456573
Eclampsia 12.99 9.22 7 127243 365 110461684
Lung opacity 12.97 9.22 36 127214 11616 110450433
Transferrin decreased 12.96 9.22 8 127242 540 110461509
Repetitive strain injury 12.94 9.22 6 127244 226 110461823
Abdominal wall haemorrhage 12.93 9.22 9 127241 744 110461305
Quadriparesis 12.88 9.22 21 127229 4686 110457363
Laryngitis 12.85 9.22 18 127232 42393 110419656
Dysphoria 12.85 9.22 25 127225 6403 110455646
Pancytopenia 12.83 9.22 167 127083 209446 110252603
Axillary nerve injury 12.72 9.22 4 127246 50 110461999
Cholestasis of pregnancy 12.70 9.22 11 127239 1254 110460795
Accidental exposure to product by child 12.70 9.22 17 127233 3181 110458868
Localised infection 12.69 9.22 89 127161 42959 110419090
Vascular stenosis 12.67 9.22 9 127241 769 110461280
Heliotrope rash 12.65 9.22 6 127244 238 110461811
Spinal cord ischaemia 12.65 9.22 6 127244 238 110461811
Retrograde amnesia 12.57 9.22 9 127241 778 110461271
Brain herniation 12.57 9.22 30 127220 8833 110453216
Anal ulcer 12.50 9.22 13 127237 1863 110460186
Intraocular pressure increased 12.50 9.22 34 127216 10842 110451207
Streptococcal infection 12.47 9.22 34 127216 10856 110451193
Phrenic nerve paralysis 12.45 9.22 8 127242 579 110461470
Infusion site streaking 12.41 9.22 8 127242 582 110461467
Prostate cancer 12.41 9.22 15 127235 37626 110424423
Pregnancy 12.40 9.22 25 127225 51042 110411007
Ejection fraction decreased 12.34 9.22 85 127165 40795 110421254
Bacteroides infection 12.34 9.22 16 127234 2903 110459146
Pseudomonas infection 12.32 9.22 64 127186 27789 110434260
Hyperlipidaemia 12.32 9.22 77 127173 35771 110426278
Superinfection 12.24 9.22 23 127227 5740 110456309
Enterobacter pneumonia 12.23 9.22 8 127242 597 110461452
Finger deformity 12.22 9.22 12 127238 33080 110428969
Vascular resistance systemic decreased 12.16 9.22 6 127244 260 110461789
Administration site pain 12.14 9.22 9 127241 822 110461227
Exophthalmos 12.10 9.22 14 127236 2259 110459790
Osteonecrosis of jaw 12.10 9.22 23 127227 47994 110414055
Cellulitis 12.06 9.22 208 127042 125808 110336241
Ventricular asystole 12.06 9.22 7 127243 422 110461627
Harlequin syndrome 12.05 9.22 6 127244 265 110461784
Schizophrenia 12.05 9.22 5 127245 21821 110440228
Agranulocytosis 12.00 9.22 34 127216 61726 110400323
Deafness neurosensory 12.00 9.22 31 127219 9588 110452461
Vitreous floaters 11.98 9.22 30 127220 9104 110452945
Body dysmorphic disorder 11.97 9.22 7 127243 428 110461621
Wrong route 11.95 9.22 3 127247 15 110462034
Uveitis 11.94 9.22 5 127245 21705 110440344
Oxidative stress 11.93 9.22 4 127246 62 110461987
Intellectual disability 11.92 9.22 13 127237 1966 110460083
Haematochezia 11.91 9.22 193 127057 115331 110346718
Allergy to immunoglobulin therapy 11.88 9.22 5 127245 149 110461900
Air embolism 11.82 9.22 8 127242 632 110461417
Spinal stroke 11.82 9.22 4 127246 64 110461985
Myokymia 11.82 9.22 5 127245 151 110461898
Irregular breathing 11.81 9.22 8 127242 633 110461416
Glossoptosis 11.77 9.22 6 127244 279 110461770
Infusion site rash 11.76 9.22 14 127236 2329 110459720
Lung neoplasm malignant 11.68 9.22 13 127237 33829 110428220
Pulmonary toxicity 11.67 9.22 3 127247 17743 110444306
Nail bed inflammation 11.65 9.22 13 127237 2017 110460032
Road traffic accident 11.64 9.22 74 127176 107324 110354725
Intelligence test abnormal 11.63 9.22 3 127247 17 110462032
Accelerated idioventricular rhythm 11.63 9.22 6 127244 286 110461763
Speech disorder 11.56 9.22 115 127135 61454 110400595
Femoral nerve injury 11.54 9.22 4 127246 69 110461980
Pustule 11.50 9.22 17 127233 3487 110458562
Kidney infection 11.44 9.22 59 127191 25540 110436509
Erythema of eyelid 11.44 9.22 18 127232 3897 110458152
Sensory loss 11.43 9.22 52 127198 21405 110440644
Arthritis infective 11.39 9.22 32 127218 10397 110451652
Blood 25-hydroxycholecalciferol decreased 11.38 9.22 7 127243 469 110461580
Allodynia 11.38 9.22 13 127237 2070 110459979
Aortic stenosis 11.37 9.22 37 127213 13022 110449027
Spinal cord oedema 11.36 9.22 7 127243 471 110461578
Total lung capacity decreased 11.10 9.22 25 127225 7089 110454960
Vasculitis 11.10 9.22 15 127235 35858 110426191
Encephalomalacia 11.09 9.22 11 127239 1491 110460558
Calcinosis 11.08 9.22 15 127235 2837 110459212
Scleral hyperaemia 10.99 9.22 6 127244 321 110461728
Swelling face 10.97 9.22 158 127092 92163 110369886
Monoplegia 10.94 9.22 20 127230 4889 110457160
Orbital infection 10.89 9.22 5 127245 184 110461865
Abnormal sensation in eye 10.87 9.22 13 127237 2173 110459876
Dermatitis atopic 10.82 9.22 58 127192 25483 110436566
Adverse drug reaction 10.80 9.22 74 127176 105485 110356564
Full blood count abnormal 10.79 9.22 31 127219 56021 110406028
Conjunctival oedema 10.76 9.22 11 127239 1545 110460504
Disease recurrence 10.72 9.22 35 127215 60749 110401300
Nasal mucosal disorder 10.71 9.22 12 127238 1871 110460178
Arthritis bacterial 10.66 9.22 32 127218 10788 110451261
Myotonic dystrophy 10.65 9.22 5 127245 194 110461855
Blindness transient 10.51 9.22 22 127228 5934 110456115
Acute pulmonary oedema 10.44 9.22 43 127207 16953 110445096
Sinusitis 10.42 9.22 429 126821 296259 110165790
Varicose vein 10.40 9.22 24 127226 6916 110455133
End-tidal CO2 decreased 10.39 9.22 4 127246 94 110461955
Sinus arrest 10.37 9.22 18 127232 4224 110457825
Arthritis fungal 10.37 9.22 5 127245 206 110461843
Laboratory test abnormal 10.35 9.22 22 127228 44057 110417992
Intentional product misuse to child 10.35 9.22 5 127245 207 110461842
Opisthotonus 10.34 9.22 8 127242 778 110461271
Device infusion issue 10.32 9.22 15 127235 3030 110459019
Nerve block 10.32 9.22 8 127242 781 110461268
Intraocular pressure fluctuation 10.31 9.22 4 127246 96 110461953
Keratitis 10.27 9.22 20 127230 5124 110456925
Hypoaesthesia 10.27 9.22 279 126971 313944 110148105
Iron binding capacity total decreased 10.26 9.22 7 127243 560 110461489
Accidental exposure to product 10.18 9.22 95 127155 49913 110412136
Bacterial infection 10.16 9.22 89 127161 45947 110416102
Pemphigoid 10.12 9.22 5 127245 19702 110442347
Gastrooesophageal reflux disease 10.07 9.22 146 127104 179830 110282219
Hypercapnia 10.06 9.22 32 127218 11127 110450922
Meningitis 10.05 9.22 33 127217 11669 110450380
Endocrine ophthalmopathy 10.03 9.22 10 127240 1363 110460686
Impaired quality of life 10.02 9.22 64 127186 29953 110432096
Foetal death 10.01 9.22 3 127247 16042 110446007
Peripheral nerve decompression 10.01 9.22 4 127246 104 110461945
Anaesthetic complication cardiac 9.98 9.22 4 127246 105 110461944
Ventricular hypokinesia 9.97 9.22 32 127218 11182 110450867
Angioedema 9.94 9.22 164 127086 98336 110363713
Open globe injury 9.94 9.22 5 127245 226 110461823
Cerebral congestion 9.92 9.22 5 127245 227 110461822
Infection susceptibility increased 9.90 9.22 18 127232 4380 110457669
Coccygectomy 9.89 9.22 3 127247 33 110462016
Sympathectomy 9.89 9.22 3 127247 33 110462016
Dystonia 9.87 9.22 57 127193 25748 110436301
Corneal abrasion 9.82 9.22 10 127240 1399 110460650
Injection site joint swelling 9.81 9.22 3 127247 34 110462015
Pupillary reflex impaired 9.77 9.22 17 127233 3998 110458051
Pneumonia mycoplasmal 9.74 9.22 11 127239 1730 110460319
Atelectasis 9.73 9.22 74 127176 36638 110425411
Postictal state 9.71 9.22 13 127237 2433 110459616
Tremor 9.71 9.22 303 126947 201929 110260120
Procedural anxiety 9.70 9.22 8 127242 853 110461196
Perineal cyst 9.68 9.22 5 127245 239 110461810
Tachypnoea 9.67 9.22 78 127172 39317 110422732
Renal transplant 9.62 9.22 15 127235 3223 110458826
Liver function test increased 9.60 9.22 61 127189 88487 110373562
Mean arterial pressure increased 9.57 9.22 4 127246 117 110461932
Panniculitis 9.57 9.22 3 127247 15579 110446470
Victim of chemical submission 9.56 9.22 8 127242 871 110461178
Ingrowing nail 9.54 9.22 15 127235 3247 110458802
Procedural haemorrhage 9.53 9.22 20 127230 5407 110456642
Testicular haemorrhage 9.51 9.22 5 127245 248 110461801
Incision site rash 9.43 9.22 3 127247 39 110462010
Hyperparathyroidism secondary 9.39 9.22 15 127235 3289 110458760
Drug eruption 9.39 9.22 31 127219 53628 110408421
Infusion site nodule 9.38 9.22 6 127244 431 110461618
Walking aid user 9.37 9.22 9 127241 25066 110436983
Spinal osteoarthritis 9.36 9.22 47 127203 20136 110441913
Pancreatitis 9.36 9.22 66 127184 93467 110368582
Spinal stenosis 9.28 9.22 45 127205 19011 110443038
Rectal prolapse 9.23 9.22 13 127237 2550 110459499
Renal failure 9.23 9.22 333 126917 226241 110235808

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AG04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
ATC A06AX01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Other drugs for constipation
FDA CS M0000728 Allergens
FDA CS M0009417 Glycerol
MeSH PA D003451 Cryoprotective Agents
MeSH PA D012997 Solvents
MeSH PA D020011 Protective Agents
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA PE N0000185001 Increased IgG Production
FDA EPC N0000185370 Non-Standardized Chemical Allergen
CHEBI has role CHEBI:25728 osmolyte
CHEBI has role CHEBI:27780 detergent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:46787 solvent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50503 laxative
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:84735 algal metabolite
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

A06AG Enemas 5 drugs
bisacodyldantrondocusate sodiumsodium phosphatesorbitol
A06AX Other drugs for constipation 7 drugs
elobixibatlinaclotidelubiprostoneplecanatideprucalopridetegaserodtenapanor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017411 VUID
N0000145799 NUI
D00028 KEGG_DRUG
4017411 VANDF
C0017861 UMLSCUI
CHEBI:17754 CHEBI
CRY PDB_CHEM_ID
CHEMBL692 ChEMBL_ID
753 PUBCHEM_CID
DB09462 DRUGBANK_ID
D005990 MESH_DESCRIPTOR_UI
5195 IUPHAR_LIGAND_ID
4910 RXNORM
108842 MMSL
399991 MMSL
4792 MMSL
52080 MMSL
602 MMSL
d00652 MMSL
001176 NDDF
001893 NDDF
002240 NDDF
002291 NDDF
002469 NDDF
004085 NDDF
404833002 SNOMEDCT_US
80582002 SNOMEDCT_US
444 INN_ID
PDC6A3C0OX UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REFRESH TEARS PF HUMAN OTC DRUG LABEL 2 0023-3110 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH TEARS PF HUMAN OTC DRUG LABEL 2 0023-3110 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH OPTIVE HUMAN OTC DRUG LABEL 2 0023-3240 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Optive HUMAN OTC DRUG LABEL 2 0023-3416 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Relieva PF Xtra HUMAN OTC DRUG LABEL 2 0023-3782 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Relieva PF Xtra HUMAN OTC DRUG LABEL 2 0023-3782 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Optive Mega-3 PF HUMAN OTC DRUG LABEL 3 0023-3988 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH Optive Mega-3 HUMAN OTC DRUG LABEL 3 0023-4230 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4307 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4307 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4491 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 12 sections
REFRESH OPTIVE Advanced HUMAN OTC DRUG LABEL 3 0023-4491 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 12 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-4515 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH OPTIVE Drops HUMAN OTC DRUG LABEL 2 0023-5459 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH Optive Mega-3 HUMAN OTC DRUG LABEL 3 0023-5773 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Relieva HUMAN OTC DRUG LABEL 2 0023-6630 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 2 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Relieva Preservative Free HUMAN OTC DRUG LABEL 2 0023-6634 SOLUTION/ DROPS 9 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Digital HUMAN OTC DRUG LABEL 3 0023-6952 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
Refresh Digital PF HUMAN OTC DRUG LABEL 3 0023-6954 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
REFRESH Optive Mega-3 HUMAN OTC DRUG LABEL 3 0023-7151 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
Endura HUMAN PRESCRIPTION DRUG LABEL 2 0023-9235 SOLUTION/ DROPS 1 g OPHTHALMIC Export only 1 sections
Refresh RELIEVA PF HUMAN OTC DRUG LABEL 2 0023-9537 SOLUTION/ DROPS 10 mg OPHTHALMIC OTC Monograph Drug 11 sections
GenTeal Tears (Moderate) HUMAN OTC DRUG LABEL 3 0065-0426 SOLUTION/ DROPS 2 mg OPHTHALMIC OTC Monograph Drug 13 sections
Good Sense HemorrhoidalMaximum Strength Pain Relief HUMAN OTC DRUG LABEL 4 0113-0944 CREAM 14.40 g TOPICAL OTC Monograph Drug 14 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0075 SUPPOSITORY 2 g RECTAL OTC Monograph Drug 15 sections
FLEET HUMAN OTC DRUG LABEL 1 0132-0090 SUPPOSITORY 2 g RECTAL Export only 15 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0185 LIQUID 5.40 g RECTAL OTC Monograph Drug 13 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0190 LIQUID 2.80 g RECTAL OTC Monograph Drug 12 sections
Pedia-Lax HUMAN OTC DRUG LABEL 1 0132-0195 LIQUID 2.80 g RECTAL OTC Monograph Drug 12 sections