All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

glipizide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihyperglycaemics	1301	29094-61-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glypidizine glidiazinamide K 4024 K-4024 K4024 glipizide dipazide glibenese glipizid glucotrol glucozide glupizide glydiazinamide melizide napizide sucrazide	An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. Molecular weight: 445.54 Formula: C21H27N5O4S CLOGP: 2.60 LIPINSKI: 0 HAC: 9 HDO: 3 TPSA: 130.15 ALOGS: -4.43 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	4.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.96 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	95 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.16 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.56 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.30 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 8, 1984	FDA	PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	683.95	12.09	482	35613	83274	63369653
Hypoglycaemia	417.90	12.09	314	35781	59751	63393176
Cardiac failure congestive	326.25	12.09	328	35767	92105	63360822
Blood glucose decreased	288.85	12.09	168	35927	20784	63432143
Coronary artery disease	198.21	12.09	157	35938	32220	63420707
Myocardial infarction	197.50	12.09	263	35832	99630	63353297
Diabetes mellitus inadequate control	151.61	12.09	99	35996	15027	63437900
Product residue present	129.23	12.09	57	36038	3922	63449005
Cerebrovascular accident	122.48	12.09	220	35875	107804	63345123
Contraindicated product administered	109.78	12.09	3	36092	217645	63235282
Glycosylated haemoglobin increased	109.46	12.09	75	36020	12323	63440604
Blood glucose fluctuation	85.90	12.09	45	36050	4531	63448396
Pancreatitis	84.58	12.09	121	35974	48934	63403993
Drug intolerance	79.61	12.09	38	36057	308623	63144304
Infusion related reaction	79.00	12.09	21	36074	245500	63207427
Synovitis	72.76	12.09	10	36085	186908	63266019
Off label use	72.58	12.09	174	35921	674288	62778639
Rheumatoid arthritis	72.24	12.09	27	36068	253792	63199135
Systemic lupus erythematosus	70.85	12.09	16	36079	208902	63244025
Exposure during pregnancy	69.17	12.09	5	36090	155542	63297385
Glossodynia	68.62	12.09	10	36085	178866	63274061
Lactic acidosis	68.30	12.09	96	35999	38191	63414736
Product complaint	67.60	12.09	57	36038	12752	63440175
Drug ineffective	63.52	12.09	343	35752	1044422	62408505
Treatment failure	62.19	12.09	18	36077	199025	63253902
Hyperglycaemia	61.75	12.09	96	35999	41771	63411156
Pericarditis	59.16	12.09	4	36091	131575	63321352
Hypoglycaemic coma	59.07	12.09	29	36066	2546	63450381
Renal failure	56.55	12.09	171	35924	117481	63335446
Arthropathy	53.12	12.09	34	36061	234758	63218169
Blood glucose abnormal	52.01	12.09	40	36055	7852	63445075
Joint swelling	52.00	12.09	66	36029	327600	63125327
Lower respiratory tract infection	51.66	12.09	7	36088	132300	63320627
Mental status changes	50.50	12.09	85	36010	39514	63413413
Diabetes mellitus	50.08	12.09	103	35992	55707	63397220
Product use issue	49.80	12.09	32	36063	220488	63232439
Euglycaemic diabetic ketoacidosis	49.39	12.09	29	36066	3645	63449282
General physical health deterioration	48.60	12.09	27	36068	201375	63251552
Wound	45.37	12.09	18	36077	163245	63289682
Discomfort	44.04	12.09	20	36075	167354	63285573
Ischaemic cardiomyopathy	42.66	12.09	23	36072	2454	63450473
Diabetic ketoacidosis	42.01	12.09	55	36040	20450	63432477
Dehydration	41.67	12.09	202	35893	173152	63279775
Product dose omission issue	41.42	12.09	251	35844	234062	63218865
Musculoskeletal stiffness	40.04	12.09	28	36067	184590	63268337
C-reactive protein increased	39.48	12.09	4	36091	94703	63358224
Acute kidney injury	39.10	12.09	270	35825	263145	63189782
Helicobacter infection	38.47	12.09	4	36091	92781	63360146
Chest pain	37.94	12.09	231	35864	215728	63237199
Pyrexia	35.78	12.09	142	35953	470336	62982591
Acute myocardial infarction	34.55	12.09	64	36031	32060	63420867
Cutaneous T-cell dyscrasia	34.47	12.09	8	36087	62	63452865
Alopecia	33.90	12.09	90	36005	337446	63115481
Asthenia	33.89	12.09	350	35745	383254	63069673
Oedema peripheral	33.46	12.09	203	35892	189308	63263619
Thrombosis	32.88	12.09	96	35999	64659	63388268
Swelling	32.81	12.09	67	36028	275311	63177616
Myocardial ischaemia	31.96	12.09	38	36057	12821	63440106
Urinary tract infection	30.66	12.09	256	35839	264428	63188499
Nodular rash	30.24	12.09	9	36086	196	63452731
Hepatic enzyme increased	29.79	12.09	43	36052	202285	63250642
Transient ischaemic attack	29.63	12.09	66	36029	37687	63415240
Cardiac disorder	28.39	12.09	78	36017	50738	63402189
Diabetic neuropathy	28.13	12.09	21	36074	3943	63448984
Gout	27.81	12.09	36	36059	13235	63439692
Chronic kidney disease	27.71	12.09	72	36023	45326	63407601
Product appearance confusion	26.77	12.09	6	36089	39	63452888
Weight decreased	26.56	12.09	257	35838	276541	63176386
Chronic obstructive pulmonary disease	26.32	12.09	87	36008	62599	63390328
Arthralgia	24.87	12.09	206	35889	569504	62883423
Stool analysis abnormal	24.86	12.09	6	36089	56	63452871
Therapeutic product effect decreased	24.74	12.09	45	36050	193142	63259785
Product use in unapproved indication	24.50	12.09	40	36055	179040	63273887
Condition aggravated	24.27	12.09	132	35963	402085	63050842
Ventricular hypertrophy	23.93	12.09	18	36077	3418	63449509
Renal injury	23.63	12.09	28	36067	9411	63443516
Hypoacusis	23.36	12.09	46	36049	24105	63428822
Pancreatitis acute	23.03	12.09	49	36046	27117	63425810
Pernicious anaemia	23.00	12.09	10	36085	664	63452263
Drug abuse	21.83	12.09	7	36088	72511	63380416
Coronary artery occlusion	21.68	12.09	25	36070	8166	63444761
Cardiovascular disorder	21.63	12.09	30	36065	11782	63441145
Diarrhoea	21.49	12.09	545	35550	714821	62738106
Nausea	21.46	12.09	636	35459	853835	62599092
Irritable bowel syndrome	21.43	12.09	10	36085	82402	63370525
Knee arthroplasty	20.84	12.09	3	36092	54203	63398724
Acute coronary syndrome	20.49	12.09	27	36068	10099	63442828
Suicide attempt	19.97	12.09	5	36090	60913	63392014
Dizziness	19.17	12.09	347	35748	429578	63023349
Death	19.16	12.09	309	35786	374072	63078855
Treatment noncompliance	18.62	12.09	55	36040	37270	63415657
Injection site nodule	18.07	12.09	16	36079	3819	63449108
Liver injury	17.94	12.09	6	36089	60514	63392413
Ventricular dysfunction	17.91	12.09	14	36081	2814	63450113
Dilatation atrial	17.47	12.09	12	36083	1979	63450948
Haemorrhage intracranial	17.36	12.09	29	36066	13390	63439537
Product quality issue	17.09	12.09	52	36043	35813	63417114
Plasma cell myeloma	17.05	12.09	52	36043	35853	63417074
Hyperinsulinaemia	16.88	12.09	5	36090	107	63452820
Rhabdomyolysis	16.70	12.09	59	36036	43892	63409035
Cellulitis	16.54	12.09	91	36004	81867	63371060
Abdominal discomfort	16.35	12.09	111	35984	320774	63132153
Hyperlipidaemia	16.25	12.09	35	36060	19536	63433391
Angina unstable	16.06	12.09	20	36075	7075	63445852
Adenocarcinoma pancreas	15.80	12.09	9	36086	1069	63451858
Blood potassium increased	15.49	12.09	33	36062	18276	63434651
Hip arthroplasty	15.44	12.09	4	36091	47642	63405285
Emotional distress	15.33	12.09	47	36048	32502	63420425
Haemodialysis	15.31	12.09	22	36073	8925	63444002
Pancreatitis haemorrhagic	15.28	12.09	7	36088	526	63452401
Abortion spontaneous	15.23	12.09	4	36091	47191	63405736
Hypersensitivity	15.03	12.09	101	35994	292584	63160343
Acute respiratory failure	14.60	12.09	48	36047	34437	63418490
Intentional product use issue	14.47	12.09	32	36063	127860	63325067
Hypervolaemia	14.30	12.09	42	36053	28371	63424556
Fear	14.02	12.09	29	36066	15737	63437190
Leukopenia	13.94	12.09	14	36081	77276	63375651
Peripheral vascular disorder	13.64	12.09	17	36078	6018	63446909
Blood triglycerides increased	13.58	12.09	25	36070	12463	63440464
Arteriosclerosis coronary artery	13.47	12.09	20	36075	8353	63444574
Coronary artery stenosis	13.44	12.09	15	36080	4729	63448198
Pancreatic carcinoma	13.41	12.09	19	36076	7609	63445318
Infection	13.37	12.09	76	36019	229097	63223830
International normalised ratio increased	13.29	12.09	57	36038	46368	63406559
Glucose urine present	13.18	12.09	7	36088	725	63452202
Unevaluable event	13.14	12.09	61	36034	51325	63401602
Gastrointestinal haemorrhage	13.09	12.09	85	36010	81091	63371836
Angioedema	13.05	12.09	58	36037	47907	63405020
Loss of personal independence in daily activities	13.04	12.09	22	36073	97268	63355659
Blood pressure fluctuation	13.03	12.09	5	36090	46312	63406615
Cardiomegaly	12.94	12.09	30	36065	17584	63435343
Completed suicide	12.86	12.09	133	35962	145540	63307387
Therapeutic product effect incomplete	12.79	12.09	33	36062	125023	63327904
Psoriasis	12.79	12.09	89	36006	86868	63366059
Essential hypertension	12.72	12.09	15	36080	5018	63447909
Blister	12.71	12.09	35	36060	129779	63323148
Flatulence	12.68	12.09	46	36049	34656	63418271
Hypoglycaemic seizure	12.68	12.09	6	36089	486	63452441
Fluid retention	12.53	12.09	67	36028	59619	63393308
Fall	12.35	12.09	301	35794	392033	63060894
Pregnancy	12.12	12.09	3	36092	36833	63416094

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	674.42	12.16	520	37152	54120	34865139
Blood glucose increased	528.47	12.16	492	37180	66226	34853033
Cardiac failure congestive	305.54	12.16	411	37261	82859	34836400
Myocardial infarction	270.79	12.16	475	37197	120610	34798649
Coronary artery disease	193.29	12.16	249	37423	48056	34871203
Blood glucose decreased	182.87	12.16	135	37537	13102	34906157
Completed suicide	141.71	12.16	321	37351	97847	34821412
Off label use	119.88	12.16	167	37505	419357	34499902
Glycosylated haemoglobin increased	92.02	12.16	85	37587	11275	34907984
Cerebrovascular accident	91.28	12.16	248	37424	84563	34834696
Drug abuse	83.65	12.16	6	37666	99090	34820169
Pancreatitis	64.94	12.16	135	37537	38756	34880503
Product complaint	61.65	12.16	51	37621	5839	34913420
Blood glucose abnormal	59.11	12.16	50	37622	5902	34913357
Diabetes mellitus inadequate control	54.71	12.16	70	37602	13394	34905865
General physical health deterioration	50.01	12.16	39	37633	128230	34791029
Product residue present	49.55	12.16	33	37639	2713	34916546
Product use in unapproved indication	49.37	12.16	33	37639	117466	34801793
Myocardial ischaemia	47.73	12.16	75	37597	17333	34901926
Injury	47.14	12.16	82	37590	20605	34898654
Mental status changes	45.64	12.16	116	37556	37967	34881292
Febrile neutropenia	43.52	12.16	50	37622	136799	34782460
Cardiovascular disorder	40.41	12.16	52	37620	10004	34909255
Cardiac disorder	40.38	12.16	120	37552	43006	34876253
Ischaemic cardiomyopathy	39.05	12.16	41	37631	6348	34912911
C-reactive protein increased	38.69	12.16	6	37666	54092	34865167
Diabetic neuropathy	37.12	12.16	33	37639	4164	34915095
Myasthenic syndrome	34.57	12.16	15	37657	516	34918743
Blood glucose fluctuation	32.24	12.16	30	37642	4014	34915245
Interstitial lung disease	32.21	12.16	15	37657	65267	34853992
Neutropenia	31.56	12.16	77	37595	156701	34762558
Spur cell anaemia	29.85	12.16	8	37664	58	34919201
Emotional distress	27.25	12.16	54	37618	14972	34904287
Autoimmune myocarditis	27.01	12.16	10	37662	225	34919034
Pyrexia	26.77	12.16	230	37442	332783	34586476
Hypophagia	26.55	12.16	71	37601	23951	34895308
Drug ineffective	26.37	12.16	341	37331	456410	34462849
Diabetic ketoacidosis	25.98	12.16	59	37613	17973	34901286
Pancreatitis acute	25.10	12.16	77	37595	28064	34891195
Arteriosclerosis	24.14	12.16	45	37627	11923	34907336
Asthenia	23.94	12.16	384	37288	244867	34674392
Acute myocardial infarction	23.26	12.16	117	37555	53602	34865657
Transient ischaemic attack	23.20	12.16	74	37598	27539	34891720
Angina unstable	22.50	12.16	43	37629	11610	34907649
Diabetes mellitus	21.66	12.16	104	37568	46769	34872490
Product dose omission issue	20.93	12.16	209	37463	119502	34799757
Unresponsive to stimuli	20.59	12.16	71	37601	27498	34891761
Anhedonia	19.85	12.16	32	37640	7553	34911706
Type 2 diabetes mellitus	19.37	12.16	49	37623	15983	34903276
Arteriosclerosis coronary artery	19.28	12.16	42	37630	12443	34906816
Intentional product use issue	18.84	12.16	22	37650	59794	34859465
Renal injury	18.83	12.16	39	37633	11156	34908103
Drug resistance	18.26	12.16	3	37669	25924	34893335
Interstitial granulomatous dermatitis	18.22	12.16	7	37665	175	34919084
Cardiomyopathy	17.89	12.16	49	37623	16759	34902500
Bladder cancer	17.87	12.16	48	37624	16230	34903029
Gastrointestinal mucosal necrosis	17.86	12.16	7	37665	185	34919074
Leukopenia	17.84	12.16	25	37647	62831	34856428
Acute kidney injury	16.90	12.16	439	37233	304549	34614710
Agranulocytosis	16.24	12.16	3	37669	23818	34895441
Autoimmune myositis	16.17	12.16	6	37666	136	34919123
Glycosylated haemoglobin decreased	16.05	12.16	8	37664	379	34918880
Treatment failure	16.01	12.16	16	37656	46681	34872578
Diverticulum	15.81	12.16	28	37644	7131	34912128
Condition aggravated	15.73	12.16	132	37540	192064	34727195
Product quality issue	15.55	12.16	47	37625	16988	34902271
Altered state of consciousness	15.36	12.16	3	37669	22890	34896369
Renal failure	15.27	12.16	211	37461	130346	34788913
Product use issue	15.25	12.16	28	37644	63188	34856071
Pancreatic carcinoma	14.96	12.16	31	37641	8870	34910389
Poor quality product administered	14.92	12.16	14	37658	1893	34917366
Glycosylated haemoglobin abnormal	14.72	12.16	6	37666	176	34919083
Drug intolerance	14.72	12.16	26	37646	59544	34859715
Mucosal inflammation	14.71	12.16	12	37660	38610	34880649
Alanine aminotransferase increased	14.49	12.16	42	37630	80773	34838486
Chest pain	14.47	12.16	204	37468	126558	34792701
Peripheral vascular disorder	14.22	12.16	22	37650	5014	34914245
COVID-19	14.13	12.16	40	37632	77510	34841749
Weight decreased	13.92	12.16	267	37405	176034	34743225
Suicide attempt	13.87	12.16	13	37659	39103	34880156
Neutrophil count decreased	13.84	12.16	21	37651	51083	34868176
Blood pressure fluctuation	13.75	12.16	5	37667	25244	34894015
Hyperglycaemia	13.72	12.16	81	37591	39399	34879860
Electrocardiogram ST-T change	13.16	12.16	8	37664	561	34918698
Lower respiratory tract infection	13.12	12.16	9	37663	31628	34887631
Hyphaema	12.93	12.16	8	37664	579	34918680
Cytomegalovirus infection	12.89	12.16	6	37666	26129	34893130
Coronary artery occlusion	12.72	12.16	33	37639	10929	34908330
International normalised ratio increased	12.71	12.16	91	37581	47236	34872023
Vision blurred	12.71	12.16	89	37583	45874	34873385
Fear	12.64	12.16	32	37640	10444	34908815
Expiratory reserve volume decreased	12.63	12.16	4	37668	55	34919204
Infusion related reaction	12.36	12.16	24	37648	53033	34866226

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	1081.43	11.54	752	56338	100842	79586456
Blood glucose increased	824.40	11.54	672	56418	114303	79572995
Cardiac failure congestive	525.36	11.54	576	56514	141826	79545472
Myocardial infarction	476.97	11.54	622	56468	183507	79503791
Blood glucose decreased	360.36	11.54	228	56862	26006	79661292
Coronary artery disease	340.28	11.54	319	56771	65155	79622143
Cerebrovascular accident	205.06	11.54	385	56705	154907	79532391
Completed suicide	174.47	11.54	476	56614	245291	79442007
Off label use	157.46	11.54	255	56835	906960	78780338
Glycosylated haemoglobin increased	149.21	11.54	118	56972	19142	79668156
Product residue present	126.19	11.54	58	57032	3478	79683820
Diabetes mellitus inadequate control	112.32	11.54	111	56979	24153	79663145
Pancreatitis	97.94	11.54	176	56914	68399	79618899
Drug ineffective	92.82	11.54	429	56661	1080484	78606814
Mental status changes	92.01	11.54	169	56921	66790	79620508
Drug intolerance	91.93	11.54	37	57053	264082	79423216
Contraindicated product administered	86.43	11.54	7	57083	157531	79529767
Product complaint	85.02	11.54	73	57017	13276	79674022
Rheumatoid arthritis	83.37	11.54	23	57067	208447	79478851
Drug abuse	82.02	11.54	10	57080	162681	79524617
Ischaemic cardiomyopathy	81.72	11.54	57	57033	7638	79679660
General physical health deterioration	80.05	11.54	49	57041	275189	79412109
Blood glucose abnormal	73.92	11.54	61	57029	10505	79676793
Infusion related reaction	72.70	11.54	37	57053	230200	79457098
Synovitis	71.88	11.54	11	57079	150723	79536575
Myocardial ischaemia	70.24	11.54	89	57001	25430	79661868
Acute myocardial infarction	68.89	11.54	163	56927	76873	79610425
Cardiac disorder	68.69	11.54	148	56942	65609	79621689
Lactic acidosis	68.57	11.54	154	56936	70205	79617093
Blood glucose fluctuation	67.49	11.54	48	57042	6634	79680664
Acute kidney injury	63.29	11.54	608	56482	518796	79168502
C-reactive protein increased	62.48	11.54	9	57081	129018	79558280
Euglycaemic diabetic ketoacidosis	61.93	11.54	46	57044	6798	79680500
Hand deformity	61.81	11.54	3	57087	103916	79583382
Cardiovascular disorder	59.61	11.54	69	57021	17956	79669342
Hyperglycaemia	58.79	11.54	145	56945	70190	79617108
Treatment failure	57.50	11.54	25	57065	170461	79516837
Lower respiratory tract infection	56.06	11.54	12	57078	129208	79558090
Diabetic ketoacidosis	55.80	11.54	93	56997	34029	79653269
Renal failure	54.55	11.54	286	56804	200682	79486616
Product use in unapproved indication	53.70	11.54	60	57030	250299	79436999
Diabetic neuropathy	52.30	11.54	40	57050	6176	79681122
Hypoglycaemic coma	52.29	11.54	36	57054	4724	79682574
Transient ischaemic attack	50.96	11.54	115	56975	52580	79634718
Diabetes mellitus	50.74	11.54	147	56943	78243	79609055
Product dose omission issue	50.73	11.54	327	56763	247210	79440088
Asthenia	49.59	11.54	572	56518	511117	79176181
Pericarditis	48.80	11.54	8	57082	104228	79583070
Pyrexia	48.67	11.54	286	56804	678423	79008875
Arthropathy	46.82	11.54	35	57055	177076	79510222
Product use issue	44.21	11.54	51	57039	209771	79477527
Death	43.69	11.54	607	56483	565907	79121391
Angina unstable	42.90	11.54	56	57034	16471	79670827
Chest pain	42.86	11.54	347	56743	281957	79405341
Systemic lupus erythematosus	42.07	11.54	17	57073	121132	79566166
Musculoskeletal stiffness	40.84	11.54	39	57051	174969	79512329
Hypophagia	40.56	11.54	96	56994	45271	79642027
Joint swelling	38.71	11.54	94	56996	288552	79398746
Chronic obstructive pulmonary disease	38.00	11.54	141	56949	85278	79602020
Dehydration	37.62	11.54	305	56785	247882	79439416
Glossodynia	36.71	11.54	14	57076	103323	79583975
Rhabdomyolysis	35.34	11.54	157	56933	102974	79584324
Pancreatitis acute	34.02	11.54	95	56995	49509	79637789
Coronary artery occlusion	33.85	11.54	48	57042	15267	79672031
Myasthenic syndrome	33.82	11.54	15	57075	827	79686471
Helicobacter infection	33.42	11.54	5	57085	69699	79617599
Treatment noncompliance	32.85	11.54	97	56993	52171	79635127
Product quality issue	32.73	11.54	74	57016	33866	79653432
Cutaneous T-cell dyscrasia	32.63	11.54	8	57082	62	79687236
Arteriosclerosis coronary artery	32.45	11.54	51	57039	17765	79669533
Emotional distress	31.92	11.54	81	57009	39888	79647410
Bladder cancer	31.63	11.54	53	57037	19473	79667825
Renal injury	31.59	11.54	49	57041	16878	79670420
Condition aggravated	31.34	11.54	220	56870	500904	79186394
Arthralgia	31.09	11.54	261	56829	571542	79115756
International normalised ratio increased	30.57	11.54	131	56959	84590	79602708
Febrile neutropenia	30.36	11.54	76	57014	230923	79456375
Arteriosclerosis	30.23	11.54	50	57040	18177	79669121
Hypoacusis	29.37	11.54	66	57024	30084	79657214
Alopecia	28.96	11.54	78	57012	231277	79456021
Spur cell anaemia	28.29	11.54	8	57082	113	79687185
Unresponsive to stimuli	28.16	11.54	96	56994	55692	79631606
Intentional product use issue	27.89	11.54	41	57049	152071	79535227
Drug reaction with eosinophilia and systemic symptoms	27.79	11.54	6	57084	64238	79623060
Peripheral vascular disorder	26.99	11.54	31	57059	7999	79679299
Therapeutic product effect decreased	26.46	11.54	48	57042	163815	79523483
Neutropenia	26.43	11.54	111	56979	287599	79399699
Interstitial lung disease	26.37	11.54	25	57065	112575	79574723
Gamma-glutamyltransferase increased	26.03	11.54	4	57086	54676	79632622
Discomfort	25.95	11.54	31	57059	125586	79561712
Blood pressure fluctuation	25.74	11.54	8	57082	67137	79620161
Infection	25.60	11.54	88	57002	241624	79445674
Gastrointestinal haemorrhage	25.40	11.54	187	56903	147532	79539766
Autoimmune myocarditis	25.37	11.54	10	57080	409	79686889
Oedema peripheral	25.25	11.54	284	56806	252004	79435294
Chronic kidney disease	25.20	11.54	104	56986	66050	79621248
Acute coronary syndrome	24.91	11.54	50	57040	21083	79666215
Wound	24.72	11.54	28	57062	116151	79571147
Irritable bowel syndrome	24.62	11.54	7	57083	62234	79625064
Nodular rash	24.24	11.54	9	57081	312	79686986
Thrombosis	23.70	11.54	121	56969	83979	79603319
Anhedonia	23.55	11.54	40	57050	14858	79672440
Mitral valve incompetence	22.93	11.54	58	57032	28507	79658791
Atrial fibrillation	22.71	11.54	229	56861	197657	79489641
Stool analysis abnormal	22.63	11.54	7	57083	137	79687161
Suicide attempt	22.41	11.54	16	57074	82916	79604382
Occult blood positive	22.18	11.54	26	57064	6857	79680441
Inflammation	21.74	11.54	21	57069	93732	79593566
Angioedema	21.15	11.54	109	56981	75926	79611372
Cellulitis	21.05	11.54	142	56948	108918	79578380
Hyperlipidaemia	20.96	11.54	53	57037	26040	79661258
Injury	20.80	11.54	110	56980	77386	79609912
Cardiomyopathy	20.62	11.54	56	57034	28718	79658580
Drug resistance	20.30	11.54	3	57087	42210	79645088
Fear	20.16	11.54	47	57043	21939	79665359
Agranulocytosis	19.90	11.54	4	57086	45026	79642272
Therapeutic product effect incomplete	19.87	11.54	45	57045	141600	79545698
Gout	19.60	11.54	50	57040	24699	79662599
Gastrointestinal mucosal necrosis	19.41	11.54	7	57083	223	79687075
Dizziness	19.22	11.54	503	56587	525938	79161360
Hyperkalaemia	19.20	11.54	144	56946	114254	79573044
Glycosylated haemoglobin abnormal	19.18	11.54	7	57083	231	79687067
Haemodialysis	19.09	11.54	41	57049	18127	79669171
Interstitial granulomatous dermatitis	19.07	11.54	7	57083	235	79687063
Pernicious anaemia	18.87	11.54	9	57081	587	79686711
Blood creatinine increased	18.54	11.54	181	56909	154876	79532422
Cognitive disorder	18.23	11.54	14	57076	69912	79617386
Plasma cell myeloma	18.18	11.54	81	57009	53178	79634120
Essential hypertension	18.08	11.54	22	57068	6031	79681267
Leukopenia	18.04	11.54	35	57055	116478	79570820
Fibromyalgia	17.93	11.54	12	57078	64328	79622970
Dialysis	17.52	11.54	40	57050	18422	79668876
Poor quality product administered	17.47	11.54	17	57073	3628	79683670
Type 2 diabetes mellitus	17.38	11.54	84	57006	57038	79630260
Dilatation atrial	17.24	11.54	17	57073	3687	79683611
Ventricular hypertrophy	17.22	11.54	23	57067	6915	79680383
Cholestasis	17.00	11.54	8	57082	52101	79635197
Urinary tract infection	16.79	11.54	283	56807	274229	79413069
Weight decreased	16.50	11.54	351	56739	354847	79332451
Cytomegalovirus infection	16.49	11.54	5	57085	42639	79644659
Toe amputation	16.46	11.54	17	57073	3894	79683404
Hyperinsulinaemia	16.35	11.54	6	57084	201	79687097
Blood potassium increased	16.22	11.54	52	57038	29223	79658075
Diabetic retinopathy	15.86	11.54	15	57075	3091	79684207
Altered state of consciousness	15.45	11.54	6	57084	43816	79643482
Gastrointestinal disorder	15.43	11.54	41	57049	122164	79565134
Epilepsy	15.43	11.54	5	57085	40855	79646443
Hyphaema	15.34	11.54	9	57081	895	79686403
Coronary artery stenosis	15.27	11.54	30	57060	12454	79674844
Liver injury	15.19	11.54	11	57079	56603	79630695
Blood loss anaemia	15.18	11.54	34	57056	15464	79671834
Cardiac arrest	15.12	11.54	189	56901	171907	79515391
Hypersensitivity	14.99	11.54	118	56972	262121	79425177
Unevaluable event	14.98	11.54	79	57011	55506	79631792
Vision blurred	14.88	11.54	128	56962	105770	79581528
Product appearance confusion	14.82	11.54	4	57086	47	79687251
Impaired healing	14.76	11.54	25	57065	87630	79599668
Product solubility abnormal	14.74	11.54	9	57081	963	79686335
Myopathy	14.71	11.54	40	57050	20523	79666775
Hepatic enzyme increased	14.65	11.54	74	57016	182536	79504762
Hypervolaemia	14.62	11.54	65	57025	42625	79644673
Oedema	14.49	11.54	140	56950	119440	79567858
Carotid artery stenosis	14.49	11.54	24	57066	8734	79678564
Lung disorder	14.48	11.54	22	57068	80535	79606763
Aortic stenosis	14.41	11.54	22	57068	7473	79679825
Multiple injuries	14.37	11.54	15	57075	3480	79683818
Psoriatic arthropathy	14.31	11.54	21	57069	77978	79609320
Full blood count decreased	14.28	11.54	47	57043	26772	79660526
Hip arthroplasty	14.18	11.54	4	57086	35752	79651546
Autoimmune myositis	14.14	11.54	6	57084	297	79687001
Glucose urine present	14.12	11.54	11	57079	1745	79685553
High density lipoprotein decreased	14.04	11.54	17	57073	4638	79682660
Product physical issue	13.80	11.54	16	57074	4169	79683129
Nasopharyngitis	13.70	11.54	116	56974	253765	79433533
Alanine aminotransferase increased	13.55	11.54	65	57025	162505	79524793
Circulatory collapse	13.55	11.54	5	57085	37663	79649635
Hypoglycaemic seizure	13.45	11.54	8	57082	816	79686482
Fall	13.44	11.54	450	56640	487179	79200119
Hepatocellular injury	13.10	11.54	9	57081	47584	79639714
Tricuspid valve incompetence	12.78	11.54	37	57053	19675	79667623
Electrocardiogram ST-T change	12.76	11.54	10	57080	1599	79685699
Human anaplasmosis	12.76	11.54	4	57086	82	79687216
Osteoporosis	12.68	11.54	12	57078	54100	79633198
Sinusitis	12.60	11.54	85	57005	195416	79491882
Anaphylactic shock	12.58	11.54	5	57085	35991	79651307
Expiratory reserve volume decreased	12.45	11.54	4	57086	89	79687209
Right ventricular failure	12.35	11.54	41	57049	23456	79663842
Fluid retention	12.35	11.54	89	57001	69720	79617578
Haemorrhage intracranial	12.29	11.54	44	57046	26149	79661149
Neutrophil count decreased	12.26	11.54	31	57059	93928	79593370
Angina pectoris	12.25	11.54	71	57019	51661	79635637
Neurotoxicity	12.24	11.54	4	57086	32514	79654784
Eczema	12.22	11.54	7	57083	40811	79646487
Knee arthroplasty	12.14	11.54	8	57082	43240	79644058
Incorrect route of product administration	11.96	11.54	5	57085	34924	79652374
Laryngeal pain	11.83	11.54	18	57072	6096	79681202
Electrocardiogram QT prolonged	11.66	11.54	30	57060	90356	79596942

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10BB07	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Sulfonylureas
FDA CS	M0020795	Sulfonylurea Compounds
CHEBI has role	CHEBI:35526	antidiabetic
CHEBI has role	CHEBI:77194	ATP:pantothenate 4-phosphotransferase inhibitor
CHEBI has role	CHEBI:90415	insulin secretagogues
MeSH PA	D007004	Hypoglycemic Agents
FDA EPC	N0000175608	Sulfonylurea

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352
Alcoholism	contraindication	7200002
Asthenia	contraindication	13791008
Myocardial infarction	contraindication	22298006	DOID:5844
Acute vomiting	contraindication	23971007
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Dehydration	contraindication	34095006
Infectious disease	contraindication	40733004
Hepatic porphyria	contraindication	55056006	DOID:3133
Ketoacidosis	contraindication	56051008
Metabolic acidosis	contraindication	59455009
Hemolytic anemia	contraindication	61261009	DOID:583
Glucose-6-phosphate dehydrogenase deficiency anemia	contraindication	62403005
Hypopituitarism	contraindication	74728003	DOID:9406
Cardiogenic shock	contraindication	89138009
Kidney disease	contraindication	90708001	DOID:557
Lactic acidosis	contraindication	91273001	DOID:3650
Cobalamin deficiency	contraindication	190634004
Decompensated cardiac failure	contraindication	195111005
Disease of liver	contraindication	235856003	DOID:409
Hypoglycemic disorder	contraindication	237630007
Sepsis syndrome	contraindication	238150007
Primary adrenocortical insufficiency	contraindication	373662000
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Fever	contraindication	386661006
Surgical procedure	contraindication	387713003
Severe diarrhea	contraindication	409587002
Traumatic injury	contraindication	417746004
Fever greater than 100.4 Fahrenheit	contraindication	426000000
Prolonged-Severe Nausea and Vomiting	contraindication
Radiography with IV Iodinated Contrast Agent	contraindication
Severe Hypoxemia	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.31	acidic
pKa2	11.71	acidic
pKa3	12.9	acidic
pKa4	3.19	Basic
pKa5	0.2	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sulfonylurea receptor 1, Kir6.2	Ion channel	Q09428 Q14654	ABCC8_HUMAN KCJ11_HUMAN	BLOCKER	Kd	9.10		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
4018508	VUID
N0000146830	NUI
D00335	KEGG_DRUG
4018508	VANDF
C0017642	UMLSCUI
CHEBI:5384	CHEBI
CHEMBL1073	ChEMBL_ID
D005913	MESH_DESCRIPTOR_UI
DB01067	DRUGBANK_ID
6821	IUPHAR_LIGAND_ID
3090	INN_ID
X7WDT95N5C	UNII
3478	PUBCHEM_CID
151822	RXNORM
4783	MMSL
574	MMSL
595	MMSL
d00246	MMSL
000913	NDDF
26124005	SNOMEDCT_US
387143009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Glucotrol XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-0170	TABLET, EXTENDED RELEASE	2.50 mg	ORAL	NDA	27 sections
Glucotrol XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-0170	TABLET, EXTENDED RELEASE	2.50 mg	ORAL	NDA	27 sections
Glucotrol XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-0174	TABLET, EXTENDED RELEASE	5 mg	ORAL	NDA	27 sections
Glucotrol XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-0174	TABLET, EXTENDED RELEASE	5 mg	ORAL	NDA	27 sections
Glucotrol XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-0178	TABLET, EXTENDED RELEASE	10 mg	ORAL	NDA	27 sections
Glucotrol XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-0178	TABLET, EXTENDED RELEASE	10 mg	ORAL	NDA	27 sections
Glipizide and Metformin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7455	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	27 sections
Glipizide and Metformin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7456	TABLET, FILM COATED	2.50 mg	ORAL	ANDA	27 sections
Glipizide and Metformin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7457	TABLET, FILM COATED	5 mg	ORAL	ANDA	27 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1105	TABLET	5 mg	ORAL	ANDA	25 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1105	TABLET	5 mg	ORAL	ANDA	25 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1110	TABLET	10 mg	ORAL	ANDA	25 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1110	TABLET	10 mg	ORAL	ANDA	25 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0460	TABLET	5 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0460	TABLET	5 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0461	TABLET	10 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0461	TABLET	10 mg	ORAL	ANDA	13 sections
GlipizideER	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0844	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	26 sections
GlipizideER	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0845	TABLET, FILM COATED, EXTENDED RELEASE	10 mg	ORAL	ANDA	26 sections
GlipizideER	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0900	TABLET, FILM COATED, EXTENDED RELEASE	2.50 mg	ORAL	ANDA	26 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7968	TABLET	5 mg	ORAL	ANDA	20 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7969	TABLET	10 mg	ORAL	ANDA	20 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8407	TABLET	5 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8407	TABLET	5 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8407	TABLET	5 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8408	TABLET	10 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8408	TABLET	10 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8408	TABLET	10 mg	ORAL	ANDA	13 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6637	TABLET	5 mg	ORAL	ANDA	20 sections
Glipizide	HUMAN PRESCRIPTION DRUG LABEL	1	10370-745	TABLET, FILM COATED, EXTENDED RELEASE	5 mg	ORAL	ANDA	25 sections