Stem definition | Drug id | CAS RN |
---|---|---|
analgesics, glafenine derivatives (subgroup of fenamic acid group) | 1297 | 3820-67-5 |
Dose | Unit | Route |
---|---|---|
0.80 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
None
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | N02BG03 | NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Other analgesics and antipyretics |
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35222 | inhibitor |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.75 | acidic |
pKa2 | 6.97 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bile salt export pump | Transporter | IC50 | 4.65 | CHEMBL | |||||
Bile salt export pump | Transporter | IC50 | 4.49 | CHEMBL |
ID | Source |
---|---|
D01351 | KEGG_DRUG |
C0017592 | UMLSCUI |
CHEBI:31653 | CHEBI |
CHEMBL146095 | ChEMBL_ID |
DB08963 | DRUGBANK_ID |
D005897 | MESH_DESCRIPTOR_UI |
3474 | PUBCHEM_CID |
1890 | INN_ID |
65513-72-6 | SECONDARY_CAS_RN |
46HL4I09AH | UNII |
006856 | NDDF |
None