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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
glafenine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group)
1297
3820-67-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
glafenine
alcidon
dolomate
glafenin
glaphenin
glaphenine
glicafan
glifanan
glifanar
glycerylaminophenaquine
privadol
glafenine hydrochloride
glafenine HCl
An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.
Molecular weight: 372.81
Formula: C19H17ClN2O4
CLOGP: 4.04
LIPINSKI: 0
HAC: 6
HDO: 3
TPSA: 91.68
ALOGS: -4.04
ROTB: 7
Drug dosage:
Dose
Unit
Route
0.80
g
O
ADMET properties:
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Property
Value
Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Hosey CM, Chan R, Benet LZ
S (Water solubility)
0.02 mg/mL
Bocci G, Oprea TI, Benet LZ
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N02BG03
NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Other analgesics and antipyretics
CHEBI has role
CHEBI:35222
inhibitor
CHEBI has role
CHEBI:35475
non-steroidal anti-inflammatory agent
MeSH PA
D000700
Analgesics
MeSH PA
D018712
Analgesics, Non-Narcotic
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D018373
Peripheral Nervous System Agents
MeSH PA
D018689
Sensory System Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.75
acidic
pKa2
6.97
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Bile salt export pump
Transporter
O95342
ABCBB_HUMAN
IC50
4.65
CHEMBL
Bile salt export pump
Transporter
ABCBB_RAT
IC50
4.49
CHEMBL
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External reference:
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ID
Source
006856
NDDF
1890
INN_ID
3474
PUBCHEM_CID
46HL4I09AH
UNII
65513-72-6
SECONDARY_CAS_RN
C0017592
UMLSCUI
CHEBI:31653
CHEBI
CHEMBL146095
ChEMBL_ID
D005897
MESH_DESCRIPTOR_UI
D01351
KEGG_DRUG
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Pharmaceutical products:
None
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glafenine