floctafenine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group) 1178 23779-99-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • idarac
  • floctafenine
  • diralgan
  • floctafenin
  • novodolan
  • Molecular weight: 406.36
  • Formula: C20H17F3N2O4
  • CLOGP: 4.24
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 91.68
  • ALOGS: -4.07
  • ROTB: 8

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BG04 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Other analgesics and antipyretics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute pain indication 274663001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.75 acidic
pKa2 7.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.96 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 6.27 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C0016245 UMLSCUI
D01267 KEGG_DRUG
4444 RXNORM
003480 NDDF
K9D19L5WTV UNII
36783-34-3 SECONDARY_CAS_RN
2936 INN_ID
DB08976 DRUGBANK_ID
CHEBI:31612 CHEBI
CHEMBL2105075 ChEMBL_ID
3360 PUBCHEM_CID
C051733 MESH_SUPPLEMENTAL_RECORD_UI
C084600 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None