gepefrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 1290 18840-47-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gepefrine
  • d-alpha-Methyl-m-tyramine
isomer of PARA-HYDROXYAMPHETAMINE which is also called alpha-methyl-tyramine
  • Molecular weight: 151.21
  • Formula: C9H13NO
  • CLOGP: 1.07
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 46.25
  • ALOGS: -1.64
  • ROTB: 2

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 95 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 48
kinase-selectivity-class AKT2,AKT3,AXL,BRAF,CAMK2B,DDR1,EPHB4,GRK2,MAP2K6,PRKCD,SIK2,STK33,TEK 13
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA15 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C01CA Adrenergic and dopaminergic agents 25 drugs
amezinium metilsulfatearbutaminecafedrinedimetofrinedobutaminedopaminedopexaminedroxidopaephedrineepinephrineetilefrinefenoldopam show all 25 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.17 acidic
pKa2 9.57 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07150 KEGG_DRUG
C0082689 UMLSCUI
CHEBI:10302 CHEBI
CHEMBL3989731 ChEMBL_ID
DB13703 DRUGBANK_ID
219105 PUBCHEM_CID
4270 INN_ID
C045355 MESH_SUPPLEMENTAL_RECORD_UI
V51RRX51VH UNII
41157 RXNORM
007016 NDDF

Pharmaceutical products:

None