Drug results: 57
| nalidixic acid | A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE. |
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| colistimethate sodium | ||
| mesna | A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE. |
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| oxolinic acid | Synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS. |
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| piromidic acid | Antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections. |
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| pipemidic acid | Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections. |
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| adenosine | A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. |
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| trovafloxacin | a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity |
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| primidone | A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. |
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| rimantadine | An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. |
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| cinoxacin | Synthetic antimicrobial related to OXOLINIC ACID and NALIDIXIC ACID and used in URINARY TRACT INFECTIONS. |
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| enoxacin | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID. |
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| clotrimazole | An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. |
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| marbofloxacin | Fluoroquinolone carboxylic acid derivative |
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| norfloxacin | A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE. |
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| miloxacin |
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| temafloxacin |
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| balofloxacin | showed potent bactericidal activity & inhibited the supercoiling activity of DNA gyrase of S. aureus, E. coli, & P aeruginosa; structure given in first source |
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| levofloxacin | The L-isomer of Ofloxacin. |
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| lomefloxacin | A synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. |
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| lascufloxacin | Lascufloxacin has strong antibacterial activity against the primary causative bacteria of community-acquired respiratory infections and also exhibits good activity against streptococci and anaerobic bacteria in the oral cavity, which have attracted attention recently as the causative bacterial of community-acquired pneumonia. Meanwhile, its penetration to the tissue of the lungs, ear, nose and throatis is good, and even at small doses, it maintains an effective drug concentration in infected tissue and demonstrates a high level of therapeutic effectiveness. |
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| garenoxacin | a des-fluoro(6) quinolone with antibacterial activity |
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| difloxacin |
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| clinafloxacin |
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| rufloxacin |
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| tosufloxacin | quinolone anti-infective agent; structure given in first source |
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| pefloxacin | A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria. |
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| pazufloxacin |
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| ozenoxacin | Ozenoxacin is a quinolone antimicrobial drug. The mechanism of action involves the inhibition of bacterial DNA replication enzymes, DNA gyrase A and topoisomerase IV. Ozenoxacin has been shown to be bactericidal against S. aureus and S. pyogenes organisms. Ozenoxacin is used as topical treatment for impetigo and other infectious dermatological conditions. |
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| delafloxacin | Delafloxacin belongs to the fluoroquinolone class of antibacterial drugs and is anionic in nature. The antibacterial activity of delafloxacin is due to the inhibition of both bacterial topoisomerase IV and DNA gyrase (topoisomerase II) enzymes which are required for bacterial DNA replication, transcription, repair, and recombination. Delafloxacin exhibits a concentration-dependent bactericidal activity against gram-positive and gram-negative bacteria in vitro. |
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| fleroxacin | A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE. |
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| ciprofloxacin | A broad-spectrum antimicrobial carboxyfluoroquinoline. |
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| grepafloxacin |
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| gemifloxacin | A naphthyridine and fluoroquinolone derivative antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used for the treatment of community-acquired pneumonia and acute bacterial infections associated with chronic bronchitis. |
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| besifloxacin | Besifloxacin is an 8-chloro fluoroquinolone with a N-1 cyclopropyl group. The compound has activity against Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme required for replication, transcription and repair of bacterial DNA. Topoisomerase IV is an essential enzyme required for partitioning of the chromosomal DNA during bacterial cell division. |
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| rosoxacin |
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| moxifloxacin | A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent. |
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| orbifloxacin |
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| danofloxacin |
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| gatifloxacin | A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS. |
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| ofloxacin | A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. |
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| sitafloxacin | Sitafloxacin hydrate is a fluoroquinolone antibiotic. It is indicated for the treatment of various infections such as respiratory infection, urologic infection, gynecologic infection, otorhinological infections, and dental infection. |
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| pradofloxacin | Veterinary fluoroquinolone; |
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| nemonoxacin | has antibacterial activity |
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| enrofloxacin | A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice |
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| prulifloxacin |
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| nadifloxacin | (R)-isomer does not induce chromosomal aberrations, unlike (S)-isomer; structure given in first source |
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| finafloxacin | Finafloxacin belongs to the fluoroquinolone class of antibacterials which involves the inhibition of bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination. |
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| zabofloxacin | Zabofloxacin is a fluoroquinolone antibiotic with enhanced in-vitro activity against Streptococcus pneumoniae, including strains resistant to other antibiotics. The spectrum of activity of Zabofloxacin includes those bacterial strains that are responsible for most community-acquired respiratory infections. |
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| alatrofloxacin | prodrug of trovafloxacin |
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| sparfloxacin |
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| pretomanid | Pretomanid Tablet is a nitroimidazooxazine antimycobacterial drug. Pretomanid kills actively replicating M. tuberculosis by inhibiting mycolic acid biosynthesis, thereby blocking cell wall production. Under anaerobic conditions, against non-replicating bacteria, pretomanid acts as a respiratory poison following nitric oxide release |
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| adenosine phosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
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| zinc oxide | A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock. |
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| potassium chloride | A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA. | |
| doconexent | a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement |
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| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
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