Substance-P receptor

Description:

Description
  • Accession: Q5DUB1
  • Swissprot: NK1R_MERUN
  • Organism: Meriones unguiculatus
  • Gene: TACR1
  • Target class: GPCR

Drug Relations:

aprepitant
Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV). Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Bioactivity details MOA