eltanolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 997 | 128-20-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 2 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 22 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:38877 | intravenous anesthetics |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | IC50 | 7.30 | WOMBAT-PK | |||||
| GABA-A receptor; anion channel | Ion channel | IC50 | 7.36 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0033008 | UMLSCUI |
| CHEBI:1712 | CHEBI |
| P9N | PDB_CHEM_ID |
| CHEMBL210952 | ChEMBL_ID |
| DB12308 | DRUGBANK_ID |
| 31402 | PUBCHEM_CID |
| 11534 | IUPHAR_LIGAND_ID |
| 6781 | INN_ID |
| BXO86P3XXW | UNII |
| D011280 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None