Scroll

econazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	983	27220-47-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: econazole econazole nitrate ecostatin micofugal	An imidazole derivative that is commonly used as a topical antifungal agent. Molecular weight: 381.68 Formula: C18H15Cl3N2O CLOGP: 5.10 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 27.05 ALOGS: -5.41 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

econazole
econazole nitrate
ecostatin
micofugal

An imidazole derivative that is commonly used as a topical antifungal agent.

Molecular weight: 381.68
Formula: C18H15Cl3N2O
CLOGP: 5.10
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 27.05
ALOGS: -5.41
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	V

ADMET properties:

Show entries

Search:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.00 mg/mL	Bocci G, Oprea TI, Benet LZ

Showing 1 to 2 of 2 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 1982	FDA

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute generalised exanthematous pustulosis	122.82	24.95	35	2211	11064	63475712
Acute motor-sensory axonal neuropathy	101.76	24.95	16	2230	273	63486503
Rash maculo-papular	83.16	24.95	34	2212	31862	63454914
International normalised ratio increased	61.91	24.95	31	2215	46394	63440382
Eosinophilia	51.68	24.95	22	2224	22734	63464042
Hypothalamic pituitary adrenal axis suppression	49.11	24.95	8	2238	172	63486604
Purpura senile	46.06	24.95	9	2237	554	63486222
Tarsal tunnel syndrome	45.89	24.95	9	2237	565	63486211
Drug interaction	45.84	24.95	48	2198	229083	63257693
Granulomatous liver disease	43.16	24.95	9	2237	769	63486007

Showing 1 to 10 of 21 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Procedural haemorrhage	49.72	26.77	12	997	2445	34953477
Pulmonary haemorrhage	32.74	26.77	12	997	10292	34945630
Rash maculo-papular	29.50	26.77	15	994	28436	34927486
Toxic skin eruption	28.00	26.77	11	998	11374	34944548

Showing 1 to 4 of 4 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute generalised exanthematous pustulosis	135.30	22.79	42	2871	17212	79724263
Rash maculo-papular	105.81	22.79	48	2865	56030	79685445
Acute motor-sensory axonal neuropathy	94.92	22.79	16	2897	413	79741062
International normalised ratio increased	65.70	22.79	40	2873	84681	79656794
Eosinophilia	55.80	22.79	29	2884	45316	79696159
Purpura senile	46.31	22.79	9	2904	521	79740954
Tarsal tunnel syndrome	46.21	22.79	9	2904	527	79740948
Hypothalamic pituitary adrenal axis suppression	43.89	22.79	8	2905	327	79741148
Procedural haemorrhage	39.14	22.79	12	2901	4694	79736781
Drug reaction with eosinophilia and systemic symptoms	38.97	22.79	26	2887	64218	79677257

Showing 1 to 10 of 25 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	D01AC03	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives
ATC	G01AF05	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
ATC	G01AF55	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
MeSH PA	D058888	14-alpha Demethylase Inhibitors
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
MeSH PA	D065607	Cytochrome P-450 Enzyme Inhibitors
MeSH PA	D004791	Enzyme Inhibitors

Showing 1 to 10 of 13 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Candidiasis of skin	indication	49883006
Pityriasis versicolor	indication	56454009	DOID:9060
Tinea corporis	indication	84849002
Tinea cruris	indication	399029005
Paronychia	off-label use	71906005	DOID:13117

Showing 1 to 6 of 6 entries

Previous1Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.49	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Cannabinoid receptor 1	GPCR	P21554	CNR1_HUMAN	Ki	4.54	DRUG MATRIX
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN	Ki	5.64	DRUG MATRIX
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN	Ki	5.34	DRUG MATRIX
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	Ki	5.37	DRUG MATRIX
Adenosine receptor A2a	GPCR	P29274	AA2AR_HUMAN	Ki	5.09	DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN	Ki	5.79	DRUG MATRIX
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN	Ki	5.05	DRUG MATRIX
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN	IC50	7.30	DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	Ki	6.65	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	Ki	5.62	DRUG MATRIX

Showing 1 to 10 of 67 entries

Previous1 2 3 4 5 6 7Next

External reference:

Show entries

Search:

ID	Source
002923	NDDF
002924	NDDF
142434	RXNORM
18952006	SNOMEDCT_US
24169-02-6	SECONDARY_CAS_RN
2446	IUPHAR_LIGAND_ID
3189	INN_ID
3198	PUBCHEM_CID
373471002	SNOMEDCT_US
4018560	VANDF

Showing 1 to 10 of 25 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
071023 ECONAZOLE NITRATE 1% / NIACINAMIDE 4%	HUMAN PRESCRIPTION DRUG LABEL	2	72934-2218	CREAM	1 g	TOPICAL	unapproved drug other	4 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-892	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	33261-956	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-466	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1303	CREAM	10 mg	TOPICAL	ANDA	20 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	52565-022	CREAM	10 mg	TOPICAL	ANDA	18 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5042	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8645	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8645	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8645	CREAM	10 mg	TOPICAL	ANDA	19 sections

Showing 1 to 10 of 27 entries

Previous1 2 3Next