All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

econazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	983	27220-47-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: econazole econazole nitrate ecostatin micofugal	An imidazole derivative that is commonly used as a topical antifungal agent. Molecular weight: 381.68 Formula: C18H15Cl3N2O CLOGP: 5.10 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 27.05 ALOGS: -5.41 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	V

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 23, 1982	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute motor-sensory axonal neuropathy	100.76	25.10	16	1897	272	50602939
Rash maculo-papular	83.43	25.10	33	1880	26608	50576603
Acute generalised exanthematous pustulosis	70.34	25.10	22	1891	8916	50594295
Hypothalamic pituitary adrenal axis suppression	49.88	25.10	8	1905	145	50603066
International normalised ratio increased	47.78	25.10	26	1887	43126	50560085
Purpura senile	46.03	25.10	9	1904	520	50602691
Tarsal tunnel syndrome	45.86	25.10	9	1904	530	50602681
Granulomatous liver disease	42.98	25.10	9	1904	734	50602477
Oedema mouth	42.41	25.10	11	1902	2279	50600932
Drug interaction	41.48	25.10	44	1869	199577	50403634
Eosinophilia	41.10	25.10	18	1895	18634	50584577
Resorption bone increased	40.21	25.10	9	1904	1002	50602209
Lip oedema	38.79	25.10	11	1902	3182	50600029
Vestibular disorder	38.18	25.10	9	1904	1260	50601951
Dermatitis exfoliative generalised	34.53	25.10	10	1903	3116	50600095
Folate deficiency	34.32	25.10	9	1904	1946	50601265
Drug reaction with eosinophilia and systemic symptoms	33.88	25.10	18	1895	28406	50574805
Rash scarlatiniform	30.21	25.10	5	1908	111	50603100
Vertigo positional	27.58	25.10	8	1905	2503	50600708
Osmotic demyelination syndrome	27.50	25.10	6	1907	594	50602617

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Procedural haemorrhage	50.57	29.95	12	844	2271	29571400
Pulmonary haemorrhage	33.96	29.95	12	844	9258	29564413

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rash maculo-papular	102.38	23.74	45	2404	46981	64449302
Acute motor-sensory axonal neuropathy	94.95	23.74	16	2433	396	64495887
Acute generalised exanthematous pustulosis	83.57	23.74	28	2421	14030	64482253
International normalised ratio increased	54.13	23.74	35	2414	79132	64417151
Tarsal tunnel syndrome	46.40	23.74	9	2440	496	64495787
Purpura senile	46.29	23.74	9	2440	502	64495781
Hypothalamic pituitary adrenal axis suppression	44.62	23.74	8	2441	286	64495997
Drug reaction with eosinophilia and systemic symptoms	42.11	23.74	26	2423	54191	64442092
Toxic skin eruption	40.43	23.74	18	2431	19266	64477017
Procedural haemorrhage	39.89	23.74	12	2437	4240	64492043
Resorption bone increased	38.88	23.74	9	2440	1159	64495124
Eosinophilia	36.72	23.74	21	2428	38055	64458228
Oedema mouth	35.31	23.74	10	2439	2863	64493420
Drug interaction	33.96	23.74	54	2395	362029	64134254
Granulomatous liver disease	33.26	23.74	8	2441	1214	64495069
Vestibular disorder	32.85	23.74	9	2440	2284	64493999
Folate deficiency	31.19	23.74	9	2440	2754	64493529
Lip oedema	29.49	23.74	10	2439	5179	64491104
Dermatitis exfoliative generalised	28.20	23.74	10	2439	5906	64490377
Pulmonary haemorrhage	26.72	23.74	12	2437	13097	64483186
Rash scarlatiniform	26.64	23.74	5	2444	231	64496052
Rash pruritic	26.58	23.74	20	2429	57384	64438899
Vertigo positional	26.38	23.74	8	2441	2903	64493380

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D01AC03	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives
ATC	G01AF05	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
ATC	G01AF55	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
MeSH PA	D058888	14-alpha Demethylase Inhibitors
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
MeSH PA	D065607	Cytochrome P-450 Enzyme Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D065606	Metabolic Side Effects of Drugs and Substances
MeSH PA	D065088	Steroid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Candidiasis of skin	indication	49883006
Pityriasis versicolor	indication	56454009	DOID:9060
Tinea corporis	indication	84849002
Tinea cruris	indication	399029005
Paronychia	off-label use	71906005	DOID:13117

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.49	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cannabinoid receptor 1	GPCR	P21554	CNR1_HUMAN		Ki	4.54		DRUG MATRIX
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	5.64		DRUG MATRIX
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	5.34		DRUG MATRIX
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	5.37		DRUG MATRIX
Adenosine receptor A2a	GPCR	P29274	AA2AR_HUMAN		Ki	5.09		DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.79		DRUG MATRIX
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	5.05		DRUG MATRIX
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	7.30		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.65		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.62		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.03		DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	5.94		DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.36		DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.20		DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.30		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.57		DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.79		DRUG MATRIX
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	5.81		DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.20		DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	5.94		DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	6.42		DRUG MATRIX
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	6.53		DRUG MATRIX
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN		Ki	5.34		DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	6.18		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.40		DRUG MATRIX
Adenosine receptor A1	GPCR	P30542	AA1R_HUMAN		Ki	5.01		DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.74		DRUG MATRIX
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	5.49		DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	5.36		DRUG MATRIX
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN		Ki	5.46		DRUG MATRIX
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN		Ki	6.29		DRUG MATRIX
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	4.86		DRUG MATRIX
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	6.70		DRUG MATRIX
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	6.52		DRUG MATRIX
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN		IC50	4.49		DRUG MATRIX
Substance-P receptor	GPCR	P25103	NK1R_HUMAN		Ki	5.19		DRUG MATRIX
Steroid 17-alpha-hydroxylase/17,20 lyase	Enzyme	P05093	CP17A_HUMAN		Ki	6.49		CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	7.40		DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	4.92		DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2	Kinase	P04626	ERBB2_HUMAN		IC50	4.86		DRUG MATRIX
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	7.54		DRUG MATRIX
Lanosterol 14-alpha demethylase	Enzyme	Q16850	CP51A_HUMAN		IC50	7.30		CHEMBL
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN		IC50	5.16		DRUG MATRIX
Indoleamine 2,3-dioxygenase 1	Enzyme	P14902	I23O1_HUMAN		IC50	5.09		CHEMBL
Substance-K receptor	GPCR	P21452	NK2R_HUMAN		Ki	5.70		DRUG MATRIX
Melanocortin receptor 5	GPCR	P33032	MC5R_HUMAN		Ki	4.43		DRUG MATRIX
Melanocortin receptor 3	GPCR	P41968	MC3R_HUMAN		Ki	4.50		DRUG MATRIX
Neuropeptide Y receptor type 2	GPCR	P49146	NPY2R_HUMAN		Ki	4.96		DRUG MATRIX
Malate dehydrogenase cytoplasmic	Enzyme	P40925	MDHC_HUMAN		IC50	4.60		CHEMBL
Calcium release-activated calcium channel protein 1	Ion channel	Q96D31	CRCM1_HUMAN		IC50	4.77		CHEMBL
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	5.13		DRUG MATRIX
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	Enzyme	Q9UNU6	CP8B1_HUMAN		IC50	6.51		CHEMBL
Lanosterol 14-alpha demethylase	Enzyme		CP51_CANAL	INHIBITOR				CHEMBL	CHEMBL
Beta-lactamase	Enzyme		AMPC_ECOLI		IC50	4.60		CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		Ki	5.17		DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	5.00		DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	5.50		DRUG MATRIX
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	5.88		DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	4.67		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		IC50	4.79		CHEMBL
Acetylcholinesterase	Enzyme		ACES_ELEEL		IC50	4.65		CHEMBL
Cholinesterase	Enzyme		CHLE_HORSE		IC50	4.76		CHEMBL
Lanosterol 14-alpha demethylase	Enzyme		CP51_MYCTU		Kd	6.70		CHEMBL
Indoleamine 2,3-dioxygenase 2	Enzyme		I23O2_MOUSE		IC50	5.12		CHEMBL
Mycocyclosin synthase	Enzyme		CP121_MYCTU		Kd	7.14		CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme		I23O1_MOUSE		IC50	4.95		CHEMBL

External reference:

ID	Source
4019740	VUID
N0000147832	NUI
D00881	KEGG_DRUG
24169-02-6	SECONDARY_CAS_RN
4018560	VANDF
4019740	VANDF
C0013547	UMLSCUI
CHEBI:4754	CHEBI
ECN	PDB_CHEM_ID
CHEMBL808	ChEMBL_ID
DB01127	DRUGBANK_ID
CHEMBL1201049	ChEMBL_ID
D004464	MESH_DESCRIPTOR_UI
3198	PUBCHEM_CID
2446	IUPHAR_LIGAND_ID
3189	INN_ID
6Z1Y2V4A7M	UNII
142434	RXNORM
45569	MMSL
4650	MMSL
002923	NDDF
002924	NDDF
18952006	SNOMEDCT_US
373471002	SNOMEDCT_US
73827006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-892	CREAM	10 mg	TOPICAL	ANDA	17 sections
ECOZA	HUMAN PRESCRIPTION DRUG LABEL	1	23710-100	AEROSOL, FOAM	10 mg	TOPICAL	NDA	30 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	33261-956	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	45802-466	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1303	CREAM	10 mg	TOPICAL	ANDA	20 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	52565-022	CREAM	10 mg	TOPICAL	ANDA	18 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5042	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8645	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8645	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8646	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8646	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8647	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8647	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	63739-085	CREAM	10 mg	TOPICAL	ANDA	13 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	68788-7406	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	68788-7406	CREAM	10 mg	TOPICAL	ANDA	19 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	68788-8170	CREAM	10 mg	TOPICAL	ANDA	17 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	68788-8174	CREAM	10 mg	TOPICAL	ANDA	20 sections
Econazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	70512-029	CREAM	10 mg	TOPICAL	ANDA	12 sections
PM EXTERNAL	HUMAN OTC DRUG LABEL	4	72689-0038	SOLUTION	10 mg	TOPICAL	unapproved drug other	7 sections
ECONAZOLE NITRATE 1% / NIACINAMIDE 4%	HUMAN PRESCRIPTION DRUG LABEL	2	72934-2073	CREAM	1 g	TOPICAL	unapproved drug other	4 sections
071023 ECONAZOLE NITRATE 1% / NIACINAMIDE 4%	HUMAN PRESCRIPTION DRUG LABEL	2	72934-2218	CREAM	1 g	TOPICAL	unapproved drug other	4 sections