dyclonine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	974	586-60-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dyclonine dyclonine hydrochloride dyclocaine dyclonin dyclonine HCl	minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure Molecular weight: 289.42 Formula: C18H27NO2 CLOGP: 4.83 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 29.54 ALOGS: -3.80 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dyclonine
dyclonine hydrochloride
dyclocaine
dyclonin
dyclonine HCl

minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure

Molecular weight: 289.42
Formula: C18H27NO2
CLOGP: 4.83
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 29.54
ALOGS: -3.80
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart rate abnormal	136.77	23.88	34	2876	4913	63481199
Blood magnesium decreased	107.84	23.88	35	2875	13163	63472949
Productive cough	104.38	23.88	53	2857	63155	63422957
Lymphadenitis	92.97	23.88	23	2887	3252	63482860
Muscle twitching	90.51	23.88	34	2876	19634	63466478
Broncholithiasis	85.39	23.88	14	2896	239	63485873
Infection	83.66	23.88	75	2835	229098	63257014
Lymph node calcification	81.59	23.88	14	2896	318	63485794
Soft tissue disorder	81.40	23.88	22	2888	4400	63481712
Clostridium difficile infection	76.71	23.88	34	2876	29888	63456224
Pneumonia viral	60.61	23.88	20	2890	7902	63478210
Bronchial wall thickening	60.54	23.88	14	2896	1485	63484627
Thrombosis	52.04	23.88	34	2876	64721	63421391
Soft tissue swelling	46.96	23.88	11	2899	1233	63484879
Lichen nitidus	44.76	23.88	7	2903	87	63486025
Liver function test abnormal	42.91	23.88	27	2883	48154	63437958
Lymphadenopathy	40.52	23.88	24	2886	38434	63447678
Completed suicide	40.29	23.88	41	2869	145632	63340480
White blood cell count decreased	40.03	23.88	40	2870	139064	63347048
Febrile neutropenia	39.61	23.88	37	2873	118412	63367700
Platelet count decreased	38.30	23.88	36	2874	116086	63370026
Therapeutic product effect incomplete	37.90	23.88	37	2873	125019	63361093
Leukopenia	37.75	23.88	30	2880	77260	63408852
Herpes zoster	36.05	23.88	30	2880	82432	63403680
Sexual abuse	32.24	23.88	6	2904	218	63485894
Tenderness	31.66	23.88	17	2893	22561	63463551
Toxicity to various agents	31.41	23.88	47	2863	247203	63238909
Arthritis	30.89	23.88	32	2878	115889	63370223
Blood cholesterol increased	30.70	23.88	29	2881	94003	63392109
Oral pain	30.63	23.88	18	2892	28376	63457736
Fibromyalgia	30.55	23.88	27	2883	80393	63405719
Soft tissue necrosis	26.48	23.88	6	2904	581	63485531
Obstructive airways disorder	24.66	23.88	14	2896	20685	63465427

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Choroiditis	83.72	32.26	16	898	1199	34954818
Endophthalmitis	77.30	32.26	18	896	3490	34952527
Completed suicide	64.95	32.26	37	877	98131	34857886
Visual acuity reduced	57.79	32.26	20	894	16129	34939888
Condition aggravated	57.34	32.26	44	870	192152	34763865
Intraocular pressure increased	55.30	32.26	15	899	5368	34950649
Eye pain	49.42	32.26	17	897	13445	34942572
Toxicity to various agents	37.21	32.26	35	879	200327	34755690

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart rate abnormal	129.78	23.99	34	3634	6023	79734697
Muscle twitching	100.14	23.99	39	3629	24725	79715995
Blood magnesium decreased	99.99	23.99	35	3633	16477	79724243
Productive cough	87.52	23.99	53	3615	88278	79652442
Lymphadenitis	84.85	23.99	23	3645	4632	79736088
Completed suicide	82.63	23.99	77	3591	245690	79495030
Broncholithiasis	78.85	23.99	13	3655	229	79740491
Clostridium difficile infection	76.73	23.99	38	3630	42647	79698073
Lymph node calcification	71.85	23.99	13	3655	402	79740318
Choroiditis	67.06	23.99	15	3653	1366	79739354
Infection	61.30	23.99	65	3603	241647	79499073
Toxicity to various agents	53.28	23.99	80	3588	421460	79319260
Endophthalmitis	52.21	23.99	17	3651	6411	79734309
Bronchial wall thickening	47.89	23.99	13	3655	2628	79738092
Pneumonia viral	46.32	23.99	17	3651	9141	79731579
Soft tissue swelling	44.87	23.99	11	3657	1490	79739230
Lichen nitidus	44.52	23.99	7	3661	90	79740630
Thrombosis	43.89	23.99	34	3634	84066	79656654
Soft tissue disorder	39.87	23.99	12	3656	3503	79737217
Soft tissue necrosis	39.34	23.99	9	3659	906	79739814
Lymphadenopathy	37.95	23.99	26	3642	53221	79687499
Intraocular pressure increased	35.43	23.99	14	3654	9191	79731529
Tenderness	33.64	23.99	18	3650	23624	79717096
Visual acuity reduced	32.56	23.99	19	3649	29450	79711270
Therapeutic product effect incomplete	30.47	23.99	35	3633	141610	79599110
White blood cell count decreased	30.00	23.99	40	3628	188248	79552472
Eye pain	28.32	23.99	19	3649	37559	79703161
Skin atrophy	26.66	23.99	10	3658	5708	79735012
Psoriasis	26.08	23.99	26	3642	89561	79651159
Platelet count decreased	24.56	23.99	37	3631	194627	79546093

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01BX02	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Other local anesthetics
ATC	R02AD04	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Anesthetics, local
CHEBI has role	CHEBI:48425	topical anesthetic
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Itching of skin	indication	418363000
Suppression of the Gag Reflex	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Mouth Irritation	indication
Conduction disorder of the heart	contraindication	44808001
Bleeding hemorrhoids	contraindication	51551000
Decreased respiratory function	contraindication	80954004
Disorder of mucous membrane	contraindication	95351003
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.79	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel protein type 10 subunit alpha	Ion channel	Q9Y5Y9	SCNAA_HUMAN	BLOCKER				DRUGBANK	CHEMBL
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.74		CHEMBL

External reference:

ID	Source
4019739	VUID
N0000147831	NUI
D00735	KEGG_DRUG
536-43-6	SECONDARY_CAS_RN
4018913	VANDF
4019739	VANDF
C0058831	UMLSCUI
CHEBI:4724	CHEBI
N8R	PDB_CHEM_ID
CHEMBL1201217	ChEMBL_ID
DB00645	DRUGBANK_ID
CHEMBL1200478	ChEMBL_ID
C100063	MESH_SUPPLEMENTAL_RECORD_UI
3180	PUBCHEM_CID
7173	IUPHAR_LIGAND_ID
640	INN_ID
078A24Q30O	UNII
23744	RXNORM
4647	MMSL
72161	MMSL
001336	NDDF
005055	NDDF
23564005	SNOMEDCT_US
370307004	SNOMEDCT_US
57164003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DycloPro	HUMAN PRESCRIPTION DRUG LABEL	1	0362-3971	SOLUTION	5 mg	TOPICAL	ANDA	18 sections
Benzethonium chloride and Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0210	LIQUID	0.23 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride and Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0210	LIQUID	0.23 mg	TOPICAL	OTC monograph not final	15 sections
Ambix First Aid	HUMAN OTC DRUG LABEL	2	10038-250	CREAM	0.01 g	TOPICAL	OTC monograph not final	11 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11673-629	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11673-629	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0128	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0128	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium Chloride and Dyclonine Hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0779	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	30142-150	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	30142-150	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	36800-382	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	36800-382	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	37808-512	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	37808-512	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	41250-132	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	41250-132	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	41520-089	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	41520-089	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	46122-525	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	46122-525	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	50804-755	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	50804-755	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	55910-144	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	55910-144	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	56104-040	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	56104-040	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Premier Solutions Liquid Bandage	HUMAN OTC DRUG LABEL	2	56104-246	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Premier Solutions Liquid Bandage	HUMAN OTC DRUG LABEL	2	56104-246	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	59779-385	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections