dyclonine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 974 586-60-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dyclonine
  • dyclonine hydrochloride
  • dyclocaine
  • dyclonin
  • dyclonine HCl
minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure
  • Molecular weight: 289.42
  • Formula: C18H27NO2
  • CLOGP: 4.83
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -3.80
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heart rate abnormal 139.13 29.00 33 2267 3959 50598865
Blood magnesium decreased 109.73 29.00 34 2266 11126 50591698
Muscle twitching 95.02 29.00 33 2267 15398 50587426
Infection 94.00 29.00 71 2229 172883 50429941
Lymphadenitis 92.71 29.00 22 2278 2638 50600186
Productive cough 86.85 29.00 44 2256 52650 50550174
Clostridium difficile infection 78.97 29.00 33 2267 25406 50577418
Soft tissue disorder 77.93 29.00 21 2279 4193 50598631
Pneumonia viral 59.55 29.00 19 2281 6815 50596009
Thrombosis 54.40 29.00 33 2267 55800 50547024
Broncholithiasis 47.95 29.00 8 2292 154 50602670
Lichen nitidus 45.95 29.00 7 2293 73 50602751
Lymph node calcification 44.87 29.00 8 2292 230 50602594
Soft tissue swelling 44.25 29.00 10 2290 966 50601858
Completed suicide 44.10 29.00 41 2259 131848 50470976
Febrile neutropenia 44.01 29.00 36 2264 97631 50505193
Liver function test abnormal 42.63 29.00 26 2274 44313 50558511
Fibromyalgia 42.29 29.00 26 2274 44952 50557872
Lymphadenopathy 41.07 29.00 23 2277 33476 50569348
Platelet count decreased 40.97 29.00 35 2265 100691 50502133
White blood cell count decreased 40.39 29.00 37 2263 116685 50486139
Herpes zoster 38.13 29.00 29 2271 70757 50532067
Blood cholesterol increased 37.42 29.00 26 2274 55189 50547635
Toxicity to various agents 37.34 29.00 47 2253 212452 50390372
Leukopenia 37.11 29.00 28 2272 67500 50535324
Bronchial wall thickening 34.22 29.00 8 2292 897 50601927
Therapeutic product effect incomplete 33.58 29.00 30 2270 91485 50511339
Arthritis 32.96 29.00 29 2271 86692 50516132
Tenderness 31.97 29.00 16 2284 18549 50584275
Oral pain 30.16 29.00 17 2283 25016 50577808

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Choroiditis 67.80 30.91 13 773 975 29572766
Completed suicide 67.41 30.91 37 749 90209 29483532
Endophthalmitis 64.56 30.91 15 771 2833 29570908
Visual acuity reduced 47.51 30.91 17 769 14859 29558882
Intraocular pressure increased 42.77 30.91 12 774 4777 29568964
Eye pain 39.86 30.91 14 772 11581 29562160
Toxicity to various agents 37.05 30.91 33 753 173628 29400113

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heart rate abnormal 131.04 24.87 33 2936 5002 64490761
Muscle twitching 106.43 24.87 38 2931 18960 64476803
Blood magnesium decreased 101.89 24.87 34 2935 13871 64481892
Completed suicide 88.76 24.87 77 2892 224337 64271426
Lymphadenitis 84.70 24.87 22 2947 3763 64492000
Clostridium difficile infection 79.62 24.87 37 2932 36126 64459637
Productive cough 70.13 24.87 43 2926 73160 64422603
Infection 66.14 24.87 60 2909 184820 64310943
Toxicity to various agents 59.44 24.87 78 2891 363435 64132328
Choroiditis 53.83 24.87 12 2957 1075 64494688
Thrombosis 46.87 24.87 33 2936 70609 64425154
Lichen nitidus 45.61 24.87 7 2962 76 64495687
Pneumonia viral 45.11 24.87 16 2953 7806 64487957
Soft tissue swelling 42.91 24.87 10 2959 1092 64494671
Endophthalmitis 42.81 24.87 14 2955 5351 64490412
Soft tissue necrosis 41.89 24.87 9 2960 679 64495084
Broncholithiasis 41.33 24.87 7 2962 146 64495617
Lymphadenopathy 38.58 24.87 25 2944 46661 64449102
Soft tissue disorder 36.36 24.87 11 2958 3265 64492498
Lymph node calcification 36.19 24.87 7 2962 312 64495451
Tenderness 33.86 24.87 17 2952 19585 64476178
White blood cell count decreased 30.64 24.87 37 2932 157800 64337963
Platelet count decreased 27.29 24.87 36 2933 167675 64328088
Therapeutic product effect incomplete 26.45 24.87 28 2941 103454 64392309
Intraocular pressure increased 26.36 24.87 11 2958 8291 64487472
Visual acuity reduced 26.09 24.87 16 2953 27125 64468638
Arthralgia 25.48 24.87 60 2909 442200 64053563

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01BX02 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Other local anesthetics
ATC R02AD04 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Anesthetics, local
CHEBI has role CHEBI:48425 topical anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Local anesthesia indication 386761002
Itching of skin indication 418363000
Suppression of the Gag Reflex indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Mouth Irritation indication
Conduction disorder of the heart contraindication 44808001
Bleeding hemorrhoids contraindication 51551000
Decreased respiratory function contraindication 80954004
Disorder of mucous membrane contraindication 95351003
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Acetylcholinesterase Enzyme IC50 6.74 CHEMBL

External reference:

IDSource
4019739 VUID
N0000147831 NUI
D00735 KEGG_DRUG
536-43-6 SECONDARY_CAS_RN
4018913 VANDF
4019739 VANDF
C0058831 UMLSCUI
CHEBI:4724 CHEBI
N8R PDB_CHEM_ID
CHEMBL1201217 ChEMBL_ID
DB00645 DRUGBANK_ID
CHEMBL1200478 ChEMBL_ID
C100063 MESH_SUPPLEMENTAL_RECORD_UI
3180 PUBCHEM_CID
7173 IUPHAR_LIGAND_ID
640 INN_ID
078A24Q30O UNII
23744 RXNORM
4647 MMSL
72161 MMSL
001336 NDDF
005055 NDDF
23564005 SNOMEDCT_US
370307004 SNOMEDCT_US
57164003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DycloPro HUMAN PRESCRIPTION DRUG LABEL 1 0362-3971 SOLUTION 5 mg TOPICAL ANDA 18 sections
Benzethonium chloride and Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 0363-0210 LIQUID 0.23 mg TOPICAL OTC monograph not final 15 sections
Ambix First Aid HUMAN OTC DRUG LABEL 2 10038-250 CREAM 0.01 g TOPICAL OTC monograph not final 11 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11673-629 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11822-0128 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium Chloride and Dyclonine Hydrochloride HUMAN OTC DRUG LABEL 2 11822-0779 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 30142-150 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 36800-382 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 37808-512 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 41250-132 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 41520-089 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 46122-525 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 50804-755 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 55910-144 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 56104-040 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Premier Solutions Liquid Bandage HUMAN OTC DRUG LABEL 2 56104-246 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 59779-385 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Skin Shield HUMAN OTC DRUG LABEL 2 63736-293 LIQUID 0.10 mL TOPICAL OTC monograph not final 14 sections
Sucrets Sore Throat Wild Cherry HUMAN OTC DRUG LABEL 1 63736-560 LOZENGE 2 mg ORAL OTC MONOGRAPH NOT FINAL 12 sections
Sucrets HUMAN OTC DRUG LABEL 3 63736-567 LOZENGE 2 mg ORAL OTC monograph not final 13 sections
Sucrets CompleteVapor Cherry HUMAN OTC DRUG LABEL 2 63736-920 LOZENGE 3 mg ORAL OTC monograph not final 14 sections
SUCRETS VAPOR CHERRY HUMAN OTC DRUG LABEL 2 63736-921 LOZENGE 2 mg ORAL OTC MONOGRAPH NOT FINAL 10 sections
CepacolSore Throat HUMAN OTC DRUG LABEL 2 63824-781 LIQUID 0.10 g ORAL OTC MONOGRAPH NOT FINAL 14 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 63868-045 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 63940-012 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 63941-546 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 68016-615 LIQUID 0.75 mg TOPICAL OTC monograph not final 14 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 69256-037 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium Chloride and Dyclonine Hydrochloride HUMAN OTC DRUG LABEL 2 69842-084 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Leader Liquid Bandage HUMAN OTC DRUG LABEL 2 70000-0599 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections