dyclonine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	974	586-60-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dyclonine dyclonine hydrochloride dyclocaine dyclonin dyclonine HCl	minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure Molecular weight: 289.42 Formula: C18H27NO2 CLOGP: 4.83 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 29.54 ALOGS: -3.80 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dyclonine
dyclonine hydrochloride
dyclocaine
dyclonin
dyclonine HCl

minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure

Molecular weight: 289.42
Formula: C18H27NO2
CLOGP: 4.83
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 29.54
ALOGS: -3.80
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart rate abnormal	139.13	29.00	33	2267	3959	50598865
Blood magnesium decreased	109.73	29.00	34	2266	11126	50591698
Muscle twitching	95.02	29.00	33	2267	15398	50587426
Infection	94.00	29.00	71	2229	172883	50429941
Lymphadenitis	92.71	29.00	22	2278	2638	50600186
Productive cough	86.85	29.00	44	2256	52650	50550174
Clostridium difficile infection	78.97	29.00	33	2267	25406	50577418
Soft tissue disorder	77.93	29.00	21	2279	4193	50598631
Pneumonia viral	59.55	29.00	19	2281	6815	50596009
Thrombosis	54.40	29.00	33	2267	55800	50547024
Broncholithiasis	47.95	29.00	8	2292	154	50602670
Lichen nitidus	45.95	29.00	7	2293	73	50602751
Lymph node calcification	44.87	29.00	8	2292	230	50602594
Soft tissue swelling	44.25	29.00	10	2290	966	50601858
Completed suicide	44.10	29.00	41	2259	131848	50470976
Febrile neutropenia	44.01	29.00	36	2264	97631	50505193
Liver function test abnormal	42.63	29.00	26	2274	44313	50558511
Fibromyalgia	42.29	29.00	26	2274	44952	50557872
Lymphadenopathy	41.07	29.00	23	2277	33476	50569348
Platelet count decreased	40.97	29.00	35	2265	100691	50502133
White blood cell count decreased	40.39	29.00	37	2263	116685	50486139
Herpes zoster	38.13	29.00	29	2271	70757	50532067
Blood cholesterol increased	37.42	29.00	26	2274	55189	50547635
Toxicity to various agents	37.34	29.00	47	2253	212452	50390372
Leukopenia	37.11	29.00	28	2272	67500	50535324
Bronchial wall thickening	34.22	29.00	8	2292	897	50601927
Therapeutic product effect incomplete	33.58	29.00	30	2270	91485	50511339
Arthritis	32.96	29.00	29	2271	86692	50516132
Tenderness	31.97	29.00	16	2284	18549	50584275
Oral pain	30.16	29.00	17	2283	25016	50577808

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Choroiditis	67.80	30.91	13	773	975	29572766
Completed suicide	67.41	30.91	37	749	90209	29483532
Endophthalmitis	64.56	30.91	15	771	2833	29570908
Visual acuity reduced	47.51	30.91	17	769	14859	29558882
Intraocular pressure increased	42.77	30.91	12	774	4777	29568964
Eye pain	39.86	30.91	14	772	11581	29562160
Toxicity to various agents	37.05	30.91	33	753	173628	29400113

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart rate abnormal	131.04	24.87	33	2936	5002	64490761
Muscle twitching	106.43	24.87	38	2931	18960	64476803
Blood magnesium decreased	101.89	24.87	34	2935	13871	64481892
Completed suicide	88.76	24.87	77	2892	224337	64271426
Lymphadenitis	84.70	24.87	22	2947	3763	64492000
Clostridium difficile infection	79.62	24.87	37	2932	36126	64459637
Productive cough	70.13	24.87	43	2926	73160	64422603
Infection	66.14	24.87	60	2909	184820	64310943
Toxicity to various agents	59.44	24.87	78	2891	363435	64132328
Choroiditis	53.83	24.87	12	2957	1075	64494688
Thrombosis	46.87	24.87	33	2936	70609	64425154
Lichen nitidus	45.61	24.87	7	2962	76	64495687
Pneumonia viral	45.11	24.87	16	2953	7806	64487957
Soft tissue swelling	42.91	24.87	10	2959	1092	64494671
Endophthalmitis	42.81	24.87	14	2955	5351	64490412
Soft tissue necrosis	41.89	24.87	9	2960	679	64495084
Broncholithiasis	41.33	24.87	7	2962	146	64495617
Lymphadenopathy	38.58	24.87	25	2944	46661	64449102
Soft tissue disorder	36.36	24.87	11	2958	3265	64492498
Lymph node calcification	36.19	24.87	7	2962	312	64495451
Tenderness	33.86	24.87	17	2952	19585	64476178
White blood cell count decreased	30.64	24.87	37	2932	157800	64337963
Platelet count decreased	27.29	24.87	36	2933	167675	64328088
Therapeutic product effect incomplete	26.45	24.87	28	2941	103454	64392309
Intraocular pressure increased	26.36	24.87	11	2958	8291	64487472
Visual acuity reduced	26.09	24.87	16	2953	27125	64468638
Arthralgia	25.48	24.87	60	2909	442200	64053563

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01BX02	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Other local anesthetics
ATC	R02AD04	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Anesthetics, local
CHEBI has role	CHEBI:48425	topical anesthetic
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Itching of skin	indication	418363000
Suppression of the Gag Reflex	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Mouth Irritation	indication
Conduction disorder of the heart	contraindication	44808001
Bleeding hemorrhoids	contraindication	51551000
Decreased respiratory function	contraindication	80954004
Disorder of mucous membrane	contraindication	95351003
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.79	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel protein type 10 subunit alpha	Ion channel	Q9Y5Y9	SCNAA_HUMAN	BLOCKER				DRUGBANK	CHEMBL
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.74		CHEMBL

External reference:

ID	Source
4019739	VUID
N0000147831	NUI
D00735	KEGG_DRUG
536-43-6	SECONDARY_CAS_RN
4018913	VANDF
4019739	VANDF
C0058831	UMLSCUI
CHEBI:4724	CHEBI
N8R	PDB_CHEM_ID
CHEMBL1201217	ChEMBL_ID
DB00645	DRUGBANK_ID
CHEMBL1200478	ChEMBL_ID
C100063	MESH_SUPPLEMENTAL_RECORD_UI
3180	PUBCHEM_CID
7173	IUPHAR_LIGAND_ID
640	INN_ID
078A24Q30O	UNII
23744	RXNORM
4647	MMSL
72161	MMSL
001336	NDDF
005055	NDDF
23564005	SNOMEDCT_US
370307004	SNOMEDCT_US
57164003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DycloPro	HUMAN PRESCRIPTION DRUG LABEL	1	0362-3971	SOLUTION	5 mg	TOPICAL	ANDA	18 sections
Benzethonium chloride and Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0210	LIQUID	0.23 mg	TOPICAL	OTC monograph not final	15 sections
Ambix First Aid	HUMAN OTC DRUG LABEL	2	10038-250	CREAM	0.01 g	TOPICAL	OTC monograph not final	11 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11673-629	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0128	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium Chloride and Dyclonine Hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0779	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	30142-150	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	36800-382	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	37808-512	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	41250-132	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	41520-089	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	46122-525	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	50804-755	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	55910-144	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	56104-040	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Premier Solutions Liquid Bandage	HUMAN OTC DRUG LABEL	2	56104-246	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	59779-385	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Skin Shield	HUMAN OTC DRUG LABEL	2	63736-293	LIQUID	0.10 mL	TOPICAL	OTC monograph not final	14 sections
Sucrets Sore Throat Wild Cherry	HUMAN OTC DRUG LABEL	1	63736-560	LOZENGE	2 mg	ORAL	OTC MONOGRAPH NOT FINAL	12 sections
Sucrets	HUMAN OTC DRUG LABEL	3	63736-567	LOZENGE	2 mg	ORAL	OTC monograph not final	13 sections
Sucrets CompleteVapor Cherry	HUMAN OTC DRUG LABEL	2	63736-920	LOZENGE	3 mg	ORAL	OTC monograph not final	14 sections
SUCRETS VAPOR CHERRY	HUMAN OTC DRUG LABEL	2	63736-921	LOZENGE	2 mg	ORAL	OTC MONOGRAPH NOT FINAL	10 sections
CepacolSore Throat	HUMAN OTC DRUG LABEL	2	63824-781	LIQUID	0.10 g	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	63868-045	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	63940-012	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	63941-546	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	68016-615	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	14 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	69256-037	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium Chloride and Dyclonine Hydrochloride	HUMAN OTC DRUG LABEL	2	69842-084	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Leader Liquid Bandage	HUMAN OTC DRUG LABEL	2	70000-0599	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections