Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 972 | 116539-59-4 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.88 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
CL (Clearance) | 8.57 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 3, 2004 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 4058.24 | 9.95 | 2001 | 220845 | 23856 | 56045365 |
Dysphoria | 3494.55 | 9.95 | 1129 | 221717 | 3713 | 56065508 |
Affect lability | 2803.44 | 9.95 | 1165 | 221681 | 8960 | 56060261 |
Irritability | 2259.03 | 9.95 | 1426 | 221420 | 28162 | 56041059 |
Suicidal ideation | 1986.87 | 9.95 | 1721 | 221125 | 56021 | 56013200 |
Agitation | 1742.03 | 9.95 | 1577 | 221269 | 54459 | 56014762 |
Hyperhidrosis | 1321.96 | 9.95 | 1742 | 221104 | 92346 | 55976875 |
Paraesthesia | 1318.09 | 9.95 | 2065 | 220781 | 128449 | 55940772 |
Sensory disturbance | 1318 | 9.95 | 743 | 222103 | 11800 | 56057421 |
Anxiety | 1296.62 | 9.95 | 2553 | 220293 | 190619 | 55878602 |
Vertigo | 1228.42 | 9.95 | 1287 | 221559 | 53285 | 56015936 |
Insomnia | 1108.40 | 9.95 | 2384 | 220462 | 189476 | 55879745 |
Nightmare | 830.44 | 9.95 | 620 | 222226 | 16206 | 56053015 |
Dizziness | 753.02 | 9.95 | 3212 | 219634 | 372928 | 55696293 |
Mood swings | 736.17 | 9.95 | 576 | 222270 | 16171 | 56053050 |
Tinnitus | 632.26 | 9.95 | 684 | 222162 | 29358 | 56039863 |
Serotonin syndrome | 608.69 | 9.95 | 632 | 222214 | 25858 | 56043363 |
Pemphigus | 604.22 | 9.95 | 3 | 222843 | 157209 | 55912012 |
Tremor | 569.96 | 9.95 | 1389 | 221457 | 119700 | 55949521 |
Hypomania | 538.31 | 9.95 | 299 | 222547 | 4603 | 56064618 |
Lethargy | 536.51 | 9.95 | 827 | 222019 | 50614 | 56018607 |
Depression | 516.96 | 9.95 | 1728 | 221118 | 178389 | 55890832 |
Glossodynia | 445.03 | 9.95 | 44 | 222802 | 152414 | 55916807 |
Confusional state | 439.67 | 9.95 | 1809 | 221037 | 206346 | 55862875 |
Hand deformity | 397.31 | 9.95 | 37 | 222809 | 134455 | 55934766 |
Systemic lupus erythematosus | 378.07 | 9.95 | 121 | 222725 | 179957 | 55889264 |
Alopecia | 353.99 | 9.95 | 384 | 222462 | 293074 | 55776147 |
Headache | 342.33 | 9.95 | 3545 | 219301 | 555499 | 55513722 |
Withdrawal syndrome | 338.05 | 9.95 | 391 | 222455 | 18071 | 56051150 |
Contraindicated product administered | 326.15 | 9.95 | 165 | 222681 | 186121 | 55883100 |
Pericarditis | 318.95 | 9.95 | 31 | 222815 | 108892 | 55960329 |
Synovitis | 316.89 | 9.95 | 121 | 222725 | 161184 | 55908037 |
Suicide attempt | 299.51 | 9.95 | 689 | 222157 | 57147 | 56012074 |
Wound | 298.96 | 9.95 | 89 | 222757 | 138715 | 55930506 |
Nausea | 285.15 | 9.95 | 4419 | 218427 | 759759 | 55309462 |
Maternal exposure during pregnancy | 282.67 | 9.95 | 203 | 222643 | 189350 | 55879871 |
Arthropathy | 257.28 | 9.95 | 248 | 222598 | 200027 | 55869194 |
Drug intolerance | 251.54 | 9.95 | 413 | 222433 | 264405 | 55804816 |
Duodenal ulcer perforation | 249.85 | 9.95 | 4 | 222842 | 68338 | 56000883 |
Abdominal discomfort | 244.67 | 9.95 | 453 | 222393 | 276821 | 55792400 |
Treatment failure | 240.55 | 9.95 | 193 | 222653 | 170199 | 55899022 |
Anti-cyclic citrullinated peptide antibody positive | 233.77 | 9.95 | 52 | 222794 | 98548 | 55970673 |
Infusion related reaction | 231.73 | 9.95 | 292 | 222554 | 208639 | 55860582 |
Discomfort | 230.01 | 9.95 | 138 | 222708 | 141623 | 55927598 |
Febrile neutropenia | 223.04 | 9.95 | 70 | 222776 | 105475 | 55963746 |
Neutropenia | 220.95 | 9.95 | 181 | 222665 | 157986 | 55911235 |
Rheumatoid arthritis | 220.89 | 9.95 | 776 | 222070 | 381828 | 55687393 |
Crying | 214.09 | 9.95 | 338 | 222508 | 21102 | 56048119 |
Completed suicide | 211.16 | 9.95 | 1068 | 221778 | 132765 | 55936456 |
Stubbornness | 211.05 | 9.95 | 70 | 222776 | 255 | 56068966 |
Feeling abnormal | 209.98 | 9.95 | 1065 | 221781 | 132537 | 55936684 |
Joint swelling | 208.04 | 9.95 | 531 | 222315 | 289269 | 55779952 |
Disturbance in attention | 207.76 | 9.95 | 422 | 222424 | 32118 | 56037103 |
Pyrexia | 203.25 | 9.95 | 910 | 221936 | 417863 | 55651358 |
Hypersensitivity | 195.67 | 9.95 | 455 | 222391 | 255953 | 55813268 |
Swelling | 193.16 | 9.95 | 413 | 222433 | 239358 | 55829863 |
Rash | 190.18 | 9.95 | 1159 | 221687 | 491888 | 55577333 |
Anaemia | 182.97 | 9.95 | 502 | 222344 | 267009 | 55802212 |
Sleep disorder | 175.25 | 9.95 | 628 | 222218 | 67035 | 56002186 |
Mood altered | 171.50 | 9.95 | 237 | 222609 | 13118 | 56056103 |
Folliculitis | 165.33 | 9.95 | 14 | 222832 | 54965 | 56014256 |
Thrombocytopenia | 159.87 | 9.95 | 182 | 222664 | 136042 | 55933179 |
Somnolence | 156.78 | 9.95 | 1146 | 221700 | 162267 | 55906954 |
Therapeutic product effect decreased | 153.64 | 9.95 | 272 | 222574 | 169180 | 55900041 |
Sleep disorder due to general medical condition, insomnia type | 152.59 | 9.95 | 4 | 222842 | 43334 | 56025887 |
Lower respiratory tract infection | 152.20 | 9.95 | 138 | 222708 | 114656 | 55954565 |
Muscle injury | 145.88 | 9.95 | 18 | 222828 | 52482 | 56016739 |
Thinking abnormal | 143.85 | 9.95 | 187 | 222659 | 9754 | 56059467 |
Helicobacter infection | 143.72 | 9.95 | 55 | 222791 | 73213 | 55996008 |
Memory impairment | 143.71 | 9.95 | 701 | 222145 | 85856 | 55983365 |
Rheumatoid factor positive | 142.00 | 9.95 | 48 | 222798 | 69012 | 56000209 |
Pancytopenia | 141.56 | 9.95 | 88 | 222758 | 88627 | 55980594 |
General physical health deterioration | 140.90 | 9.95 | 288 | 222558 | 169722 | 55899499 |
Panic attack | 130.30 | 9.95 | 265 | 222581 | 20182 | 56049039 |
Anger | 129.16 | 9.95 | 193 | 222653 | 11479 | 56057742 |
Off label use | 127.58 | 9.95 | 1499 | 221347 | 554681 | 55514540 |
Electric shock | 126.30 | 9.95 | 69 | 222777 | 1026 | 56068195 |
Blister | 123.95 | 9.95 | 149 | 222697 | 108738 | 55960483 |
C-reactive protein abnormal | 123.90 | 9.95 | 5 | 222841 | 36804 | 56032417 |
Fibromyalgia | 123.89 | 9.95 | 516 | 222330 | 59087 | 56010134 |
Product use issue | 123.48 | 9.95 | 354 | 222492 | 185687 | 55883534 |
Migraine | 121.93 | 9.95 | 671 | 222175 | 86126 | 55983095 |
Acute kidney injury | 119.69 | 9.95 | 518 | 222328 | 240245 | 55828976 |
Depressed mood | 114.99 | 9.95 | 361 | 222485 | 35998 | 56033223 |
Fatigue | 114.13 | 9.95 | 3996 | 218850 | 784556 | 55284665 |
Infection | 112.66 | 9.95 | 410 | 222436 | 199796 | 55869425 |
Impaired healing | 110.86 | 9.95 | 108 | 222738 | 86733 | 55982488 |
Coordination abnormal | 108.49 | 9.95 | 186 | 222660 | 12435 | 56056786 |
Malignant neoplasm progression | 108.02 | 9.95 | 80 | 222766 | 73507 | 55995714 |
Drug ineffective | 105.21 | 9.95 | 2805 | 220041 | 916184 | 55153037 |
Disease progression | 102.53 | 9.95 | 161 | 222685 | 105012 | 55964209 |
Stomatitis | 102.33 | 9.95 | 202 | 222644 | 120608 | 55948613 |
Inappropriate antidiuretic hormone secretion | 98.20 | 9.95 | 187 | 222659 | 13569 | 56055652 |
Affective disorder | 98.11 | 9.95 | 116 | 222730 | 5487 | 56063734 |
Abnormal behaviour | 95.65 | 9.95 | 233 | 222613 | 20039 | 56049182 |
Dyspnoea | 95.19 | 9.95 | 1713 | 221133 | 590864 | 55478357 |
Platelet count decreased | 93.48 | 9.95 | 174 | 222672 | 106209 | 55963012 |
Drug interaction | 93.29 | 9.95 | 1253 | 221593 | 208502 | 55860719 |
Tardive dyskinesia | 92.03 | 9.95 | 135 | 222711 | 7896 | 56061325 |
Fall | 90.58 | 9.95 | 1949 | 220897 | 355561 | 55713660 |
Hallucination | 90.28 | 9.95 | 410 | 222436 | 48739 | 56020482 |
Gastrointestinal tube insertion | 89.50 | 9.95 | 54 | 222792 | 978 | 56068243 |
Septic shock | 88.18 | 9.95 | 67 | 222779 | 60768 | 56008453 |
Peripheral swelling | 87.47 | 9.95 | 557 | 222289 | 234169 | 55835052 |
Cardiac failure | 85.53 | 9.95 | 120 | 222726 | 81973 | 55987248 |
Gastric bypass | 82.81 | 9.95 | 60 | 222786 | 1494 | 56067727 |
Intentional product misuse | 79.70 | 9.95 | 409 | 222437 | 51095 | 56018126 |
Pneumonia aspiration | 78.97 | 9.95 | 295 | 222551 | 32116 | 56037105 |
Ill-defined disorder | 78.83 | 9.95 | 93 | 222753 | 68450 | 56000771 |
Drug reaction with eosinophilia and systemic symptoms | 78.10 | 9.95 | 13 | 222833 | 30291 | 56038930 |
Restless legs syndrome | 78.06 | 9.95 | 193 | 222653 | 16754 | 56052467 |
Post-traumatic stress disorder | 76.25 | 9.95 | 92 | 222754 | 4446 | 56064775 |
Aggression | 75.65 | 9.95 | 225 | 222621 | 21781 | 56047440 |
Product substitution issue | 74.50 | 9.95 | 173 | 222673 | 14426 | 56054795 |
Abnormal dreams | 73.66 | 9.95 | 135 | 222711 | 9514 | 56059707 |
White blood cell count abnormal | 73.65 | 9.95 | 103 | 222743 | 5764 | 56063457 |
Multiple sclerosis relapse | 73.30 | 9.95 | 362 | 222484 | 44541 | 56024680 |
Loss of consciousness | 72.39 | 9.95 | 706 | 222140 | 108643 | 55960578 |
Coma | 71.93 | 9.95 | 443 | 222403 | 59212 | 56010009 |
Premature delivery | 68.88 | 9.95 | 12 | 222834 | 27048 | 56042173 |
Gastrointestinal disorder | 68.62 | 9.95 | 223 | 222623 | 112479 | 55956742 |
Irritable bowel syndrome | 68.43 | 9.95 | 103 | 222743 | 68355 | 56000866 |
Neutrophil count decreased | 67.07 | 9.95 | 59 | 222787 | 49763 | 56019458 |
Blood creatinine increased | 66.25 | 9.95 | 136 | 222710 | 80055 | 55989166 |
Nasal turbinate hypertrophy | 66.24 | 9.95 | 39 | 222807 | 674 | 56068547 |
Sepsis | 65.73 | 9.95 | 307 | 222539 | 139533 | 55929688 |
Somatic symptom disorder | 65.06 | 9.95 | 59 | 222787 | 2036 | 56067185 |
Renal impairment | 64.90 | 9.95 | 139 | 222707 | 80574 | 55988647 |
Intentional self-injury | 64.70 | 9.95 | 232 | 222614 | 24760 | 56044461 |
Erythema | 64.42 | 9.95 | 358 | 222488 | 155581 | 55913640 |
Leukopenia | 63.22 | 9.95 | 115 | 222731 | 70825 | 55998396 |
Pneumonia | 62.95 | 9.95 | 1184 | 221662 | 405914 | 55663307 |
Amnesia | 62.29 | 9.95 | 354 | 222492 | 45968 | 56023253 |
Personality disorder | 62.25 | 9.95 | 89 | 222757 | 5084 | 56064137 |
Mucosal inflammation | 62.23 | 9.95 | 47 | 222799 | 42763 | 56026458 |
Influenza like illness | 62.03 | 9.95 | 434 | 222412 | 60554 | 56008667 |
Interstitial lung disease | 61.87 | 9.95 | 81 | 222765 | 56982 | 56012239 |
Mania | 61.54 | 9.95 | 139 | 222707 | 11381 | 56057840 |
Sleep apnoea syndrome | 60.84 | 9.95 | 234 | 222612 | 25827 | 56043394 |
Reversible cerebral vasoconstriction syndrome | 60.57 | 9.95 | 60 | 222786 | 2317 | 56066904 |
Haemoglobin decreased | 59.26 | 9.95 | 301 | 222545 | 133836 | 55935385 |
Ascites | 57.48 | 9.95 | 39 | 222807 | 37505 | 56031716 |
Vision blurred | 57.10 | 9.95 | 540 | 222306 | 82403 | 55986818 |
Pleural effusion | 56.40 | 9.95 | 163 | 222683 | 85317 | 55983904 |
Red blood cell sedimentation rate abnormal | 55.46 | 9.95 | 5 | 222841 | 18668 | 56050553 |
Alanine aminotransferase increased | 55.42 | 9.95 | 591 | 222255 | 93071 | 55976150 |
Sopor | 54.83 | 9.95 | 195 | 222651 | 20727 | 56048494 |
Hallucination, visual | 54.82 | 9.95 | 173 | 222673 | 17295 | 56051926 |
Pulmonary fibrosis | 54.07 | 9.95 | 25 | 222821 | 29733 | 56039488 |
Hip arthroplasty | 52.89 | 9.95 | 45 | 222801 | 38578 | 56030643 |
Bone marrow failure | 52.59 | 9.95 | 23 | 222823 | 28263 | 56040958 |
White blood cell count decreased | 51.61 | 9.95 | 290 | 222556 | 125700 | 55943521 |
Colitis microscopic | 51.28 | 9.95 | 103 | 222743 | 7772 | 56061449 |
Dyskinesia | 50.62 | 9.95 | 239 | 222607 | 28869 | 56040352 |
Intervertebral discitis | 50.62 | 9.95 | 59 | 222787 | 2748 | 56066473 |
Pulmonary malformation | 50.43 | 9.95 | 23 | 222823 | 226 | 56068995 |
Cytomegalovirus infection | 50.35 | 9.95 | 8 | 222838 | 19288 | 56049933 |
Therapy interrupted | 50.24 | 9.95 | 218 | 222628 | 25407 | 56043814 |
Seizure | 50.14 | 9.95 | 734 | 222112 | 124385 | 55944836 |
Lymphocytic oesophagitis | 50.01 | 9.95 | 13 | 222833 | 13 | 56069208 |
Mental disorder | 49.53 | 9.95 | 205 | 222641 | 23399 | 56045822 |
Urinary retention | 49.18 | 9.95 | 231 | 222615 | 27843 | 56041378 |
Renal failure | 48.78 | 9.95 | 248 | 222598 | 110252 | 55958969 |
Hyperkalaemia | 48.48 | 9.95 | 79 | 222767 | 50786 | 56018435 |
Muscle twitching | 48.37 | 9.95 | 158 | 222688 | 16084 | 56053137 |
Neutropenic sepsis | 48.13 | 9.95 | 3 | 222843 | 15182 | 56054039 |
Hot flush | 47.80 | 9.95 | 333 | 222513 | 46393 | 56022828 |
Surgery | 47.51 | 9.95 | 254 | 222592 | 32232 | 56036989 |
Restlessness | 47.49 | 9.95 | 220 | 222626 | 26366 | 56042855 |
Bronchial neoplasm | 47.19 | 9.95 | 27 | 222819 | 441 | 56068780 |
Atrial fibrillation | 47.17 | 9.95 | 246 | 222600 | 108651 | 55960570 |
Coma blister | 46.84 | 9.95 | 19 | 222827 | 136 | 56069085 |
Multiple sclerosis | 46.70 | 9.95 | 226 | 222620 | 27576 | 56041645 |
Hyperaesthesia | 45.73 | 9.95 | 104 | 222742 | 8553 | 56060668 |
Neck deformity | 45.73 | 9.95 | 48 | 222798 | 1987 | 56067234 |
Extremity contracture | 45.69 | 9.95 | 39 | 222807 | 1240 | 56067981 |
Device expulsion | 44.81 | 9.95 | 33 | 222813 | 30416 | 56038805 |
Product dose omission issue | 44.50 | 9.95 | 1093 | 221753 | 203660 | 55865561 |
Hypocalcaemia | 43.86 | 9.95 | 30 | 222816 | 28730 | 56040491 |
Lung cyst | 43.69 | 9.95 | 22 | 222824 | 274 | 56068947 |
Mobility decreased | 43.22 | 9.95 | 223 | 222623 | 98768 | 55970453 |
Multiple organ dysfunction syndrome | 43.15 | 9.95 | 90 | 222756 | 52680 | 56016541 |
Bronchial haemorrhage | 42.84 | 9.95 | 27 | 222819 | 530 | 56068691 |
Liver injury | 42.75 | 9.95 | 62 | 222784 | 41786 | 56027435 |
Nervousness | 42.53 | 9.95 | 227 | 222619 | 28788 | 56040433 |
Blood pressure increased | 42.11 | 9.95 | 808 | 222038 | 144368 | 55924853 |
Hyperreflexia | 42.04 | 9.95 | 75 | 222771 | 5175 | 56064046 |
Condition aggravated | 41.97 | 9.95 | 1042 | 221804 | 343856 | 55725365 |
Rheumatoid nodule | 41.50 | 9.95 | 5 | 222841 | 14852 | 56054369 |
Rubber sensitivity | 41.49 | 9.95 | 45 | 222801 | 1935 | 56067286 |
Live birth | 41.39 | 9.95 | 13 | 222833 | 19592 | 56049629 |
Neck mass | 41.39 | 9.95 | 59 | 222787 | 3361 | 56065860 |
Balance disorder | 41.21 | 9.95 | 474 | 222372 | 76046 | 55993175 |
Paranoia | 40.94 | 9.95 | 114 | 222732 | 10630 | 56058591 |
Vomiting | 40.82 | 9.95 | 2385 | 220461 | 495843 | 55573378 |
Dry mouth | 40.75 | 9.95 | 411 | 222435 | 63794 | 56005427 |
Neoplasm progression | 40.63 | 9.95 | 40 | 222806 | 31976 | 56037245 |
C-reactive protein increased | 40.43 | 9.95 | 167 | 222679 | 78517 | 55990704 |
Gastrointestinal haemorrhage | 40.42 | 9.95 | 159 | 222687 | 75792 | 55993429 |
Pruritus | 40.32 | 9.95 | 950 | 221896 | 315673 | 55753548 |
Aspartate aminotransferase increased | 39.82 | 9.95 | 501 | 222345 | 82101 | 55987120 |
Product use in unapproved indication | 39.69 | 9.95 | 361 | 222485 | 140461 | 55928760 |
Temperature intolerance | 39.63 | 9.95 | 94 | 222752 | 7946 | 56061275 |
Oesophageal spasm | 39.44 | 9.95 | 52 | 222794 | 2750 | 56066471 |
Macular degeneration | 39.10 | 9.95 | 13 | 222833 | 18895 | 56050326 |
Oedema peripheral | 38.49 | 9.95 | 463 | 222383 | 170791 | 55898430 |
Lactic acidosis | 38.49 | 9.95 | 50 | 222796 | 35296 | 56033925 |
Hypersomnia | 38.37 | 9.95 | 147 | 222699 | 16194 | 56053027 |
Cardiac failure congestive | 38.07 | 9.95 | 198 | 222648 | 87522 | 55981699 |
Therapy cessation | 37.73 | 9.95 | 210 | 222636 | 27054 | 56042167 |
Endometrial ablation | 37.34 | 9.95 | 30 | 222816 | 875 | 56068346 |
Concussion | 37.02 | 9.95 | 93 | 222753 | 8153 | 56061068 |
Metabolic surgery | 36.24 | 9.95 | 33 | 222813 | 1145 | 56068076 |
Opsoclonus myoclonus | 36.11 | 9.95 | 16 | 222830 | 146 | 56069075 |
Pre-existing condition improved | 35.93 | 9.95 | 86 | 222760 | 7312 | 56061909 |
Rapid eye movements sleep abnormal | 35.77 | 9.95 | 15 | 222831 | 118 | 56069103 |
Disorientation | 35.74 | 9.95 | 258 | 222588 | 36355 | 56032866 |
Tachyphrenia | 35.70 | 9.95 | 34 | 222812 | 1250 | 56067971 |
Pulmonary oedema | 35.60 | 9.95 | 95 | 222751 | 51048 | 56018173 |
Major depression | 35.59 | 9.95 | 87 | 222759 | 7497 | 56061724 |
Hostility | 35.57 | 9.95 | 40 | 222806 | 1791 | 56067430 |
Respiratory tract malformation | 35.55 | 9.95 | 16 | 222830 | 152 | 56069069 |
Hypotension | 35.49 | 9.95 | 739 | 222107 | 249769 | 55819452 |
Gastrooesophageal reflux disease | 34.76 | 9.95 | 492 | 222354 | 82765 | 55986456 |
Impaired driving ability | 34.72 | 9.95 | 60 | 222786 | 4036 | 56065185 |
Death | 34.69 | 9.95 | 1058 | 221788 | 340368 | 55728853 |
Rebound nasal congestion | 34.45 | 9.95 | 10 | 222836 | 20 | 56069201 |
Neurologic neglect syndrome | 34.41 | 9.95 | 43 | 222803 | 2155 | 56067066 |
Respiratory failure | 34.12 | 9.95 | 228 | 222618 | 94834 | 55974387 |
Neuralgia | 33.79 | 9.95 | 184 | 222662 | 23511 | 56045710 |
Carotid artery thrombosis | 33.70 | 9.95 | 43 | 222803 | 2201 | 56067020 |
Palmar-plantar erythrodysaesthesia syndrome | 33.44 | 9.95 | 21 | 222825 | 21044 | 56048177 |
Libido increased | 33.21 | 9.95 | 33 | 222813 | 1279 | 56067942 |
Bruxism | 33.11 | 9.95 | 51 | 222795 | 3115 | 56066106 |
Blood cholesterol increased | 33.11 | 9.95 | 161 | 222685 | 72418 | 55996803 |
Libido decreased | 32.83 | 9.95 | 44 | 222802 | 2364 | 56066857 |
Bipolar disorder | 32.48 | 9.95 | 84 | 222762 | 7496 | 56061725 |
Morbid thoughts | 32.44 | 9.95 | 23 | 222823 | 553 | 56068668 |
Anovulatory cycle | 32.40 | 9.95 | 15 | 222831 | 153 | 56069068 |
Sacroiliitis | 32.35 | 9.95 | 47 | 222799 | 2725 | 56066496 |
Akathisia | 32.18 | 9.95 | 91 | 222755 | 8561 | 56060660 |
Blood calcium decreased | 32.17 | 9.95 | 28 | 222818 | 23741 | 56045480 |
Drug tolerance decreased | 31.91 | 9.95 | 7 | 222839 | 13404 | 56055817 |
Dissociation | 31.88 | 9.95 | 45 | 222801 | 2540 | 56066681 |
Speech disorder | 31.45 | 9.95 | 255 | 222591 | 37238 | 56031983 |
Hypomagnesaemia | 30.89 | 9.95 | 32 | 222814 | 24983 | 56044238 |
Thunderclap headache | 30.87 | 9.95 | 15 | 222831 | 172 | 56069049 |
Melaena | 30.82 | 9.95 | 40 | 222806 | 28250 | 56040971 |
Anorgasmia | 30.53 | 9.95 | 22 | 222824 | 543 | 56068678 |
Tearfulness | 30.39 | 9.95 | 54 | 222792 | 3714 | 56065507 |
Depressive symptom | 30.19 | 9.95 | 52 | 222794 | 3489 | 56065732 |
Psychotic disorder due to a general medical condition | 29.94 | 9.95 | 16 | 222830 | 227 | 56068994 |
Delusion | 29.79 | 9.95 | 105 | 222741 | 11110 | 56058111 |
Acute myeloid leukaemia | 29.70 | 9.95 | 15 | 222831 | 16957 | 56052264 |
Red blood cell sedimentation rate increased | 29.49 | 9.95 | 63 | 222783 | 36560 | 56032661 |
Head injury | 29.49 | 9.95 | 185 | 222661 | 24881 | 56044340 |
Rash maculo-papular | 29.36 | 9.95 | 43 | 222803 | 28864 | 56040357 |
Complex regional pain syndrome | 29.26 | 9.95 | 39 | 222807 | 2084 | 56067137 |
Therapy non-responder | 29.22 | 9.95 | 134 | 222712 | 61221 | 56008000 |
Weight increased | 29.02 | 9.95 | 1148 | 221698 | 228555 | 55840666 |
Epistaxis | 28.68 | 9.95 | 152 | 222694 | 66871 | 56002350 |
Transplant rejection | 28.61 | 9.95 | 3 | 222843 | 9931 | 56059290 |
Bradycardia | 28.38 | 9.95 | 154 | 222692 | 67350 | 56001871 |
Formication | 28.37 | 9.95 | 54 | 222792 | 3916 | 56065305 |
Pulmonary eosinophilia | 28.31 | 9.95 | 16 | 222830 | 255 | 56068966 |
Hypoventilation | 28.07 | 9.95 | 57 | 222789 | 4335 | 56064886 |
Drug resistance | 28.04 | 9.95 | 24 | 222822 | 20518 | 56048703 |
Bone density abnormal | 27.97 | 9.95 | 48 | 222798 | 3211 | 56066010 |
Skin haemorrhage | 27.95 | 9.95 | 85 | 222761 | 8328 | 56060893 |
Psychotic disorder | 27.79 | 9.95 | 174 | 222672 | 23384 | 56045837 |
Gastric banding | 27.70 | 9.95 | 11 | 222835 | 74 | 56069147 |
Metastases to bone | 27.61 | 9.95 | 22 | 222824 | 19486 | 56049735 |
Telangiectasia congenital | 27.56 | 9.95 | 8 | 222838 | 16 | 56069205 |
Emotional disorder | 27.56 | 9.95 | 109 | 222737 | 12186 | 56057035 |
Loss of libido | 27.50 | 9.95 | 29 | 222817 | 1207 | 56068014 |
Stiff person syndrome | 27.01 | 9.95 | 17 | 222829 | 333 | 56068888 |
Arthralgia | 26.99 | 9.95 | 1669 | 221177 | 500000 | 55569221 |
Inflammation | 26.66 | 9.95 | 162 | 222684 | 68909 | 56000312 |
Knee arthroplasty | 26.63 | 9.95 | 88 | 222758 | 44171 | 56025050 |
Pregnancy | 26.45 | 9.95 | 57 | 222789 | 32976 | 56036245 |
Skin necrosis | 26.45 | 9.95 | 8 | 222838 | 12353 | 56056868 |
Psychomotor hyperactivity | 26.13 | 9.95 | 92 | 222754 | 9728 | 56059493 |
Middle insomnia | 26.12 | 9.95 | 99 | 222747 | 10851 | 56058370 |
Gait disturbance | 25.98 | 9.95 | 838 | 222008 | 162483 | 55906738 |
Proteinuria | 25.91 | 9.95 | 19 | 222827 | 17551 | 56051670 |
Agranulocytosis | 25.77 | 9.95 | 31 | 222815 | 22628 | 56046593 |
Intentional product use issue | 25.42 | 9.95 | 262 | 222584 | 99471 | 55969750 |
Dehydration | 25.38 | 9.95 | 459 | 222387 | 158366 | 55910855 |
Autonomic dysreflexia | 25.26 | 9.95 | 16 | 222830 | 317 | 56068904 |
Ankle fracture | 25.18 | 9.95 | 130 | 222716 | 16273 | 56052948 |
Gastrostomy | 25.08 | 9.95 | 20 | 222826 | 577 | 56068644 |
Bronchial disorder | 24.98 | 9.95 | 27 | 222819 | 1156 | 56068065 |
Cognitive disorder | 24.96 | 9.95 | 301 | 222545 | 48832 | 56020389 |
Sleep terror | 24.88 | 9.95 | 22 | 222824 | 734 | 56068487 |
Sensitivity to weather change | 24.79 | 9.95 | 70 | 222776 | 6579 | 56062642 |
Pulmonary arterial hypertension | 24.48 | 9.95 | 42 | 222804 | 26461 | 56042760 |
Dysphagia | 24.40 | 9.95 | 458 | 222388 | 81489 | 55987732 |
Nasopharyngitis | 24.34 | 9.95 | 677 | 222169 | 220282 | 55848939 |
Thrombotic microangiopathy | 24.33 | 9.95 | 4 | 222842 | 9407 | 56059814 |
Metastases to liver | 24.06 | 9.95 | 30 | 222816 | 21556 | 56047665 |
Adverse event | 24.02 | 9.95 | 125 | 222721 | 55251 | 56013970 |
Oesophageal pain | 23.97 | 9.95 | 45 | 222801 | 3230 | 56065991 |
Acute respiratory distress syndrome | 23.89 | 9.95 | 31 | 222815 | 21895 | 56047326 |
Therapeutic response changed | 23.83 | 9.95 | 23 | 222823 | 860 | 56068361 |
Ejection fraction decreased | 23.81 | 9.95 | 26 | 222820 | 19815 | 56049406 |
Decreased interest | 23.73 | 9.95 | 43 | 222803 | 3003 | 56066218 |
Flat affect | 23.52 | 9.95 | 28 | 222818 | 1334 | 56067887 |
Tenosynovitis | 23.37 | 9.95 | 10 | 222836 | 12451 | 56056770 |
Intentional overdose | 22.86 | 9.95 | 388 | 222458 | 67729 | 56001492 |
Prescribed overdose | 22.86 | 9.95 | 159 | 222687 | 22137 | 56047084 |
Haemoptysis | 22.82 | 9.95 | 44 | 222802 | 26516 | 56042705 |
Drug abuse | 22.65 | 9.95 | 385 | 222461 | 67225 | 56001996 |
Aplastic anaemia | 22.63 | 9.95 | 4 | 222842 | 8924 | 56060297 |
Type 2 diabetes mellitus | 22.52 | 9.95 | 102 | 222744 | 46760 | 56022461 |
Tension | 22.43 | 9.95 | 41 | 222805 | 2883 | 56066338 |
Cerebral infarction | 22.35 | 9.95 | 34 | 222812 | 22471 | 56046750 |
Spinal operation | 22.30 | 9.95 | 72 | 222774 | 7284 | 56061937 |
Deep vein thrombosis | 22.26 | 9.95 | 196 | 222650 | 76781 | 55992440 |
Depression suicidal | 22.16 | 9.95 | 30 | 222816 | 1628 | 56067593 |
Plasma cell myeloma | 22.13 | 9.95 | 102 | 222744 | 46544 | 56022677 |
Phagophobia | 21.95 | 9.95 | 8 | 222838 | 41 | 56069180 |
Galactorrhoea | 21.93 | 9.95 | 48 | 222798 | 3847 | 56065374 |
Mydriasis | 21.56 | 9.95 | 94 | 222752 | 10977 | 56058244 |
Exposure via breast milk | 21.55 | 9.95 | 31 | 222815 | 1781 | 56067440 |
Demyelination | 21.49 | 9.95 | 64 | 222782 | 6198 | 56063023 |
Foetal death | 21.44 | 9.95 | 4 | 222842 | 8583 | 56060638 |
Lip dry | 21.40 | 9.95 | 6 | 222840 | 9734 | 56059487 |
Myelodysplastic syndrome | 21.40 | 9.95 | 20 | 222826 | 16386 | 56052835 |
Muscular weakness | 21.30 | 9.95 | 553 | 222293 | 103899 | 55965322 |
Granulomatous liver disease | 21.26 | 9.95 | 20 | 222826 | 724 | 56068497 |
Circulatory collapse | 21.07 | 9.95 | 31 | 222815 | 20772 | 56048449 |
Bone erosion | 21.05 | 9.95 | 17 | 222829 | 14957 | 56054264 |
Hallucination, auditory | 21.05 | 9.95 | 96 | 222750 | 11428 | 56057793 |
Lung disorder | 21.02 | 9.95 | 122 | 222724 | 52475 | 56016746 |
Disseminated intravascular coagulation | 20.84 | 9.95 | 24 | 222822 | 17861 | 56051360 |
Coronary artery disease | 20.84 | 9.95 | 58 | 222788 | 30738 | 56038483 |
Diplopia | 20.73 | 9.95 | 145 | 222701 | 20224 | 56048997 |
Haematotoxicity | 20.73 | 9.95 | 4 | 222842 | 8379 | 56060842 |
Antinuclear antibody negative | 20.55 | 9.95 | 12 | 222834 | 204 | 56069017 |
Clonus | 20.21 | 9.95 | 49 | 222797 | 4200 | 56065021 |
Homicidal ideation | 19.99 | 9.95 | 29 | 222817 | 1679 | 56067542 |
Coombs positive haemolytic anaemia | 19.99 | 9.95 | 14 | 222832 | 330 | 56068891 |
Creatinine renal clearance decreased | 19.88 | 9.95 | 17 | 222829 | 14542 | 56054679 |
Apathy | 19.87 | 9.95 | 73 | 222773 | 7881 | 56061340 |
Drug screen positive | 19.86 | 9.95 | 43 | 222803 | 3421 | 56065800 |
Tubulointerstitial nephritis | 19.82 | 9.95 | 22 | 222824 | 16643 | 56052578 |
Basal cell carcinoma | 19.80 | 9.95 | 44 | 222802 | 25177 | 56044044 |
Liver function test increased | 19.78 | 9.95 | 52 | 222794 | 28081 | 56041140 |
Asphyxia | 19.71 | 9.95 | 59 | 222787 | 5730 | 56063491 |
Aspergillus infection | 19.69 | 9.95 | 3 | 222843 | 7462 | 56061759 |
Adjustment disorder | 19.66 | 9.95 | 34 | 222812 | 2289 | 56066932 |
Exposure during pregnancy | 19.64 | 9.95 | 401 | 222445 | 135941 | 55933280 |
Drug hypersensitivity | 19.60 | 9.95 | 1302 | 221544 | 273903 | 55795318 |
Dysphemia | 19.51 | 9.95 | 35 | 222811 | 2425 | 56066796 |
Pneumonitis | 19.51 | 9.95 | 62 | 222784 | 31502 | 56037719 |
Pulmonary congestion | 19.47 | 9.95 | 21 | 222825 | 16094 | 56053127 |
Conversion disorder | 19.44 | 9.95 | 28 | 222818 | 1610 | 56067611 |
Sedation complication | 19.42 | 9.95 | 11 | 222835 | 11661 | 56057560 |
Hypercalcaemia | 19.40 | 9.95 | 45 | 222801 | 25366 | 56043855 |
Drug eruption | 19.37 | 9.95 | 46 | 222800 | 25717 | 56043504 |
Bacteraemia | 19.29 | 9.95 | 20 | 222826 | 15611 | 56053610 |
Hypokalaemia | 19.09 | 9.95 | 261 | 222585 | 94176 | 55975045 |
Hypnopompic hallucination | 19.03 | 9.95 | 7 | 222839 | 37 | 56069184 |
Arteriosclerosis coronary artery | 18.97 | 9.95 | 71 | 222775 | 7734 | 56061487 |
Oedema | 18.96 | 9.95 | 220 | 222626 | 81700 | 55987521 |
Hypoaesthesia | 18.76 | 9.95 | 711 | 222135 | 140780 | 55928441 |
Hyperacusis | 18.70 | 9.95 | 30 | 222816 | 1898 | 56067323 |
Shock | 18.67 | 9.95 | 36 | 222810 | 21692 | 56047529 |
Premature labour | 18.65 | 9.95 | 12 | 222834 | 11870 | 56057351 |
Muscle spasms | 18.62 | 9.95 | 692 | 222154 | 136679 | 55932542 |
Tic | 18.53 | 9.95 | 24 | 222822 | 1247 | 56067974 |
Anaphylactic reaction | 18.51 | 9.95 | 147 | 222699 | 58848 | 56010373 |
Myoclonus | 18.38 | 9.95 | 113 | 222733 | 15090 | 56054131 |
Pneumocystis jirovecii pneumonia | 18.37 | 9.95 | 21 | 222825 | 15680 | 56053541 |
Respiratory distress | 18.34 | 9.95 | 64 | 222782 | 31603 | 56037618 |
Feelings of worthlessness | 18.18 | 9.95 | 13 | 222833 | 317 | 56068904 |
Panic reaction | 18.04 | 9.95 | 44 | 222802 | 3786 | 56065435 |
Right ventricular failure | 18.01 | 9.95 | 23 | 222823 | 16356 | 56052865 |
Impulse-control disorder | 17.96 | 9.95 | 18 | 222828 | 705 | 56068516 |
Panic disorder | 17.95 | 9.95 | 34 | 222812 | 2457 | 56066764 |
Poor quality sleep | 17.84 | 9.95 | 126 | 222720 | 17629 | 56051592 |
Breast cancer metastatic | 17.77 | 9.95 | 21 | 222825 | 15448 | 56053773 |
Toxic epidermal necrolysis | 17.68 | 9.95 | 38 | 222808 | 22004 | 56047217 |
Torsade de pointes | 17.64 | 9.95 | 14 | 222832 | 12426 | 56056795 |
Hypoalbuminaemia | 17.62 | 9.95 | 10 | 222836 | 10589 | 56058632 |
Lupus-like syndrome | 17.60 | 9.95 | 14 | 222832 | 12413 | 56056808 |
Haemodialysis | 17.60 | 9.95 | 6 | 222840 | 8585 | 56060636 |
Decompression sickness | 17.51 | 9.95 | 7 | 222839 | 48 | 56069173 |
Tuberculosis | 17.50 | 9.95 | 11 | 222835 | 11018 | 56058203 |
Ophthalmic vein thrombosis | 17.50 | 9.95 | 11 | 222835 | 215 | 56069006 |
Eosinophilia | 17.48 | 9.95 | 33 | 222813 | 20044 | 56049177 |
CYP3A4 polymorphism | 17.42 | 9.95 | 8 | 222838 | 80 | 56069141 |
Bipolar I disorder | 17.36 | 9.95 | 27 | 222819 | 1663 | 56067558 |
Second primary malignancy | 17.34 | 9.95 | 4 | 222842 | 7398 | 56061823 |
Poisoning | 17.27 | 9.95 | 98 | 222748 | 12715 | 56056506 |
Sleep talking | 17.24 | 9.95 | 20 | 222826 | 927 | 56068294 |
Cough | 17.23 | 9.95 | 847 | 221999 | 259114 | 55810107 |
Lactation disorder | 17.13 | 9.95 | 13 | 222833 | 348 | 56068873 |
Heart rate decreased | 17.12 | 9.95 | 92 | 222754 | 40335 | 56028886 |
Hypoglycaemia | 17.09 | 9.95 | 140 | 222706 | 55675 | 56013546 |
Overdose | 17.08 | 9.95 | 544 | 222302 | 105286 | 55963935 |
Pulmonary toxicity | 17.05 | 9.95 | 5 | 222841 | 7878 | 56061343 |
Hypoxia | 17.05 | 9.95 | 134 | 222712 | 53763 | 56015458 |
Autonomic nervous system imbalance | 16.99 | 9.95 | 34 | 222812 | 2559 | 56066662 |
Toxic skin eruption | 16.91 | 9.95 | 13 | 222833 | 11726 | 56057495 |
Hyponatraemic encephalopathy | 16.89 | 9.95 | 11 | 222835 | 229 | 56068992 |
Cardiogenic shock | 16.86 | 9.95 | 24 | 222822 | 16301 | 56052920 |
Metastases to lung | 16.85 | 9.95 | 13 | 222833 | 11705 | 56057516 |
Self-injurious ideation | 16.84 | 9.95 | 32 | 222814 | 2318 | 56066903 |
Urinary incontinence | 16.71 | 9.95 | 185 | 222661 | 29400 | 56039821 |
Pustular psoriasis | 16.56 | 9.95 | 47 | 222799 | 4431 | 56064790 |
Cholestasis | 16.54 | 9.95 | 53 | 222793 | 26860 | 56042361 |
Toxicity to various agents | 16.45 | 9.95 | 1065 | 221781 | 223499 | 55845722 |
Polyarthritis | 16.38 | 9.95 | 7 | 222839 | 8721 | 56060500 |
Pulseless electrical activity | 16.05 | 9.95 | 4 | 222842 | 7020 | 56062201 |
Sinus congestion | 16.04 | 9.95 | 112 | 222734 | 15612 | 56053609 |
Decreased appetite | 15.99 | 9.95 | 707 | 222139 | 218524 | 55850697 |
Bradyphrenia | 15.91 | 9.95 | 60 | 222786 | 6560 | 56062661 |
Intervertebral disc protrusion | 15.80 | 9.95 | 143 | 222703 | 21551 | 56047670 |
Sinus disorder | 15.79 | 9.95 | 138 | 222708 | 20596 | 56048625 |
Alcoholism | 15.73 | 9.95 | 30 | 222816 | 2179 | 56067042 |
Device related infection | 15.72 | 9.95 | 40 | 222806 | 21840 | 56047381 |
Cystitis | 15.62 | 9.95 | 277 | 222569 | 48761 | 56020460 |
Metastases to central nervous system | 15.59 | 9.95 | 15 | 222831 | 12121 | 56057100 |
Mean cell haemoglobin concentration increased | 15.51 | 9.95 | 14 | 222832 | 480 | 56068741 |
Post-traumatic neck syndrome | 15.51 | 9.95 | 28 | 222818 | 1950 | 56067271 |
Dyspnoea exertional | 15.48 | 9.95 | 140 | 222706 | 54549 | 56014672 |
Oliguria | 15.47 | 9.95 | 7 | 222839 | 8433 | 56060788 |
Hepatotoxicity | 15.45 | 9.95 | 67 | 222779 | 31086 | 56038135 |
Hepatic steatosis | 15.30 | 9.95 | 165 | 222681 | 26049 | 56043172 |
Ischaemic stroke | 15.27 | 9.95 | 27 | 222819 | 16815 | 56052406 |
Feeling drunk | 15.21 | 9.95 | 41 | 222805 | 3751 | 56065470 |
Scoliosis | 15.17 | 9.95 | 61 | 222785 | 6872 | 56062349 |
Rhonchi | 15.13 | 9.95 | 31 | 222815 | 2373 | 56066848 |
Metabolic acidosis | 15.03 | 9.95 | 96 | 222750 | 40358 | 56028863 |
Congenital tricuspid valve atresia | 15.03 | 9.95 | 6 | 222840 | 41 | 56069180 |
Blood alkaline phosphatase increased | 15.01 | 9.95 | 227 | 222619 | 38718 | 56030503 |
Hypervolaemia | 14.97 | 9.95 | 54 | 222792 | 26404 | 56042817 |
Trigeminal neuralgia | 14.85 | 9.95 | 38 | 222808 | 3369 | 56065852 |
Transfusion | 14.85 | 9.95 | 19 | 222827 | 13501 | 56055720 |
Accidental exposure to product | 14.83 | 9.95 | 49 | 222797 | 24598 | 56044623 |
Drug-induced liver injury | 14.83 | 9.95 | 78 | 222768 | 34384 | 56034837 |
Gambling disorder | 14.82 | 9.95 | 21 | 222825 | 1190 | 56068031 |
Scar | 14.77 | 9.95 | 92 | 222754 | 12341 | 56056880 |
Eating disorder | 14.70 | 9.95 | 117 | 222729 | 16988 | 56052233 |
Hyperglycaemia | 14.66 | 9.95 | 90 | 222756 | 38191 | 56031030 |
Impatience | 14.65 | 9.95 | 12 | 222834 | 360 | 56068861 |
Naevus flammeus | 14.64 | 9.95 | 8 | 222838 | 119 | 56069102 |
Fear | 14.52 | 9.95 | 105 | 222741 | 14803 | 56054418 |
Contusion | 14.51 | 9.95 | 392 | 222454 | 128038 | 55941183 |
Intentional dose omission | 14.37 | 9.95 | 55 | 222791 | 6055 | 56063166 |
Genital pain | 14.37 | 9.95 | 12 | 222834 | 370 | 56068851 |
Maternal exposure during breast feeding | 14.19 | 9.95 | 39 | 222807 | 3608 | 56065613 |
Gastric ulcer | 14.17 | 9.95 | 44 | 222802 | 22519 | 56046702 |
Intrusive thoughts | 14.13 | 9.95 | 9 | 222837 | 180 | 56069041 |
Red blood cell count decreased | 14.07 | 9.95 | 86 | 222760 | 36531 | 56032690 |
Pulmonary hypertension | 14.03 | 9.95 | 84 | 222762 | 35860 | 56033361 |
Oesophageal food impaction | 13.96 | 9.95 | 9 | 222837 | 184 | 56069037 |
Spondyloarthropathy | 13.93 | 9.95 | 17 | 222829 | 831 | 56068390 |
Breast cancer female | 13.90 | 9.95 | 17 | 222829 | 12321 | 56056900 |
Tumour lysis syndrome | 13.87 | 9.95 | 7 | 222839 | 7916 | 56061305 |
Metastases to lymph nodes | 13.85 | 9.95 | 6 | 222840 | 7417 | 56061804 |
Feeling of despair | 13.83 | 9.95 | 28 | 222818 | 2125 | 56067096 |
Lung diffusion test decreased | 13.73 | 9.95 | 15 | 222831 | 650 | 56068571 |
Urinary hesitation | 13.65 | 9.95 | 27 | 222819 | 2015 | 56067206 |
Phobia of driving | 13.61 | 9.95 | 3 | 222843 | 0 | 56069221 |
Clitoral engorgement | 13.61 | 9.95 | 3 | 222843 | 0 | 56069221 |
Psoriasis | 13.55 | 9.95 | 471 | 222375 | 92221 | 55977000 |
Caesarean section | 13.53 | 9.95 | 27 | 222819 | 16064 | 56053157 |
Osteonecrosis of jaw | 13.53 | 9.95 | 77 | 222769 | 33281 | 56035940 |
Pseudomonas infection | 13.46 | 9.95 | 12 | 222834 | 10059 | 56059162 |
Hepatobiliary scan abnormal | 13.42 | 9.95 | 6 | 222840 | 56 | 56069165 |
Stillbirth | 13.34 | 9.95 | 4 | 222842 | 6210 | 56063011 |
Cytokine release syndrome | 13.33 | 9.95 | 14 | 222832 | 10861 | 56058360 |
Cataplexy | 13.31 | 9.95 | 21 | 222825 | 1310 | 56067911 |
Rotator cuff syndrome | 13.28 | 9.95 | 88 | 222758 | 12055 | 56057166 |
Tachyphylaxis | 13.23 | 9.95 | 10 | 222836 | 266 | 56068955 |
Immobilisation prolonged | 13.18 | 9.95 | 7 | 222839 | 98 | 56069123 |
Neuropathy peripheral | 13.15 | 9.95 | 515 | 222331 | 102378 | 55966843 |
Progressive multifocal leukoencephalopathy | 13.11 | 9.95 | 87 | 222759 | 11926 | 56057295 |
Enterococcal infection | 13.11 | 9.95 | 6 | 222840 | 7178 | 56062043 |
Holmes-Adie pupil | 13.07 | 9.95 | 5 | 222841 | 30 | 56069191 |
Leukopenia neonatal | 13.07 | 9.95 | 5 | 222841 | 30 | 56069191 |
Hepatitis C antibody positive | 13.06 | 9.95 | 7 | 222839 | 100 | 56069121 |
Respiratory tract congestion | 13.05 | 9.95 | 106 | 222740 | 15485 | 56053736 |
Cardiotoxicity | 13.03 | 9.95 | 7 | 222839 | 7643 | 56061578 |
Soft tissue injury | 13.01 | 9.95 | 23 | 222823 | 1576 | 56067645 |
Dystonia | 12.98 | 9.95 | 89 | 222757 | 12332 | 56056889 |
Somnambulism | 12.95 | 9.95 | 47 | 222799 | 5045 | 56064176 |
Road traffic accident | 12.86 | 9.95 | 168 | 222678 | 27759 | 56041462 |
Deformity | 12.80 | 9.95 | 13 | 222833 | 10242 | 56058979 |
Heat exhaustion | 12.70 | 9.95 | 7 | 222839 | 106 | 56069115 |
Angioedema | 12.68 | 9.95 | 104 | 222742 | 41349 | 56027872 |
Abdominal pain | 12.68 | 9.95 | 868 | 221978 | 257937 | 55811284 |
Skin plaque | 12.65 | 9.95 | 6 | 222840 | 7032 | 56062189 |
Drug metabolising enzyme decreased | 12.65 | 9.95 | 4 | 222842 | 12 | 56069209 |
Pathogen resistance | 12.63 | 9.95 | 4 | 222842 | 5996 | 56063225 |
Blood pressure diastolic decreased | 12.63 | 9.95 | 37 | 222809 | 19286 | 56049935 |
Diffuse large B-cell lymphoma | 12.58 | 9.95 | 6 | 222840 | 7010 | 56062211 |
Sciatic nerve injury | 12.56 | 9.95 | 12 | 222834 | 443 | 56068778 |
Radiation fibrosis | 12.54 | 9.95 | 5 | 222841 | 34 | 56069187 |
Blood lactate dehydrogenase increased | 12.51 | 9.95 | 41 | 222805 | 20634 | 56048587 |
Gun shot wound | 12.47 | 9.95 | 7 | 222839 | 110 | 56069111 |
Acute myocardial infarction | 12.41 | 9.95 | 70 | 222776 | 30323 | 56038898 |
Haemolytic anaemia | 12.40 | 9.95 | 12 | 222834 | 9673 | 56059548 |
Peripheral venous disease | 12.32 | 9.95 | 13 | 222833 | 10066 | 56059155 |
Cushingoid | 12.23 | 9.95 | 7 | 222839 | 7377 | 56061844 |
Status epilepticus | 12.23 | 9.95 | 26 | 222820 | 15115 | 56054106 |
Haematuria | 12.22 | 9.95 | 60 | 222786 | 26927 | 56042294 |
Phonophobia | 12.21 | 9.95 | 10 | 222836 | 300 | 56068921 |
Cerebral haemorrhage | 12.16 | 9.95 | 65 | 222781 | 28541 | 56040680 |
Rales | 12.15 | 9.95 | 15 | 222831 | 10825 | 56058396 |
Nephrotic syndrome | 12.15 | 9.95 | 3 | 222843 | 5297 | 56063924 |
Sternal fracture | 12.05 | 9.95 | 26 | 222820 | 2064 | 56067157 |
Mental impairment | 12.04 | 9.95 | 89 | 222757 | 12633 | 56056588 |
Anaphylactic shock | 11.89 | 9.95 | 45 | 222801 | 21695 | 56047526 |
Pulmonary haemorrhage | 11.86 | 9.95 | 6 | 222840 | 6777 | 56062444 |
Feeling jittery | 11.82 | 9.95 | 85 | 222761 | 11961 | 56057260 |
Respiratory tract infection | 11.73 | 9.95 | 89 | 222757 | 35982 | 56033239 |
Spasmodic dysphonia | 11.69 | 9.95 | 6 | 222840 | 78 | 56069143 |
Breast cancer stage I | 11.69 | 9.95 | 5 | 222841 | 6225 | 56062996 |
Electric shock sensation | 11.67 | 9.95 | 12 | 222834 | 485 | 56068736 |
Herpes simplex reactivation | 11.61 | 9.95 | 12 | 222834 | 488 | 56068733 |
Visual impairment | 11.60 | 9.95 | 380 | 222466 | 73822 | 55995399 |
Eye pain | 11.58 | 9.95 | 179 | 222667 | 30668 | 56038553 |
Parosmia | 11.57 | 9.95 | 43 | 222803 | 4668 | 56064553 |
Chronic idiopathic pain syndrome | 11.54 | 9.95 | 3 | 222843 | 3 | 56069218 |
Cytomegalovirus viraemia | 11.54 | 9.95 | 3 | 222843 | 5117 | 56064104 |
Uraemic encephalopathy | 11.51 | 9.95 | 9 | 222837 | 252 | 56068969 |
Sleep-related eating disorder | 11.44 | 9.95 | 15 | 222831 | 789 | 56068432 |
Impulsive behaviour | 11.39 | 9.95 | 21 | 222825 | 1486 | 56067735 |
Polyglandular autoimmune syndrome type II | 11.34 | 9.95 | 5 | 222841 | 45 | 56069176 |
Retching | 11.33 | 9.95 | 92 | 222754 | 13438 | 56055783 |
Escherichia infection | 11.30 | 9.95 | 18 | 222828 | 11681 | 56057540 |
Food craving | 11.28 | 9.95 | 21 | 222825 | 1498 | 56067723 |
Economic problem | 11.27 | 9.95 | 24 | 222822 | 1887 | 56067334 |
Motor dysfunction | 11.25 | 9.95 | 70 | 222776 | 9387 | 56059834 |
Supraventricular tachyarrhythmia | 11.24 | 9.95 | 6 | 222840 | 85 | 56069136 |
Rapid eye movement sleep behaviour disorder | 11.22 | 9.95 | 8 | 222838 | 194 | 56069027 |
Labelled drug-food interaction issue | 11.22 | 9.95 | 4 | 222842 | 19 | 56069202 |
Carcinoid tumour pulmonary | 11.21 | 9.95 | 11 | 222835 | 420 | 56068801 |
Abortion induced | 11.18 | 9.95 | 13 | 222833 | 9632 | 56059589 |
Ligament injury | 11.16 | 9.95 | 17 | 222829 | 1028 | 56068193 |
Antidepressant drug level increased | 11.16 | 9.95 | 9 | 222837 | 264 | 56068957 |
Liver disorder | 11.12 | 9.95 | 117 | 222729 | 44253 | 56024968 |
Epstein-Barr virus infection | 11.09 | 9.95 | 8 | 222838 | 7455 | 56061766 |
Blood pressure diastolic abnormal | 11.06 | 9.95 | 18 | 222828 | 11580 | 56057641 |
Fear of injection | 11.04 | 9.95 | 6 | 222840 | 6509 | 56062712 |
Sexual dysfunction | 11.04 | 9.95 | 34 | 222812 | 3354 | 56065867 |
Generalised anxiety disorder | 10.99 | 9.95 | 24 | 222822 | 1920 | 56067301 |
Foot amputation | 10.99 | 9.95 | 9 | 222837 | 270 | 56068951 |
Sluggishness | 10.96 | 9.95 | 42 | 222804 | 4626 | 56064595 |
Rectal haemorrhage | 10.95 | 9.95 | 108 | 222738 | 41359 | 56027862 |
Vasculitis | 10.94 | 9.95 | 27 | 222819 | 14896 | 56054325 |
Alveolar bone resorption | 10.89 | 9.95 | 5 | 222841 | 50 | 56069171 |
Polyneuropathy | 10.88 | 9.95 | 22 | 222824 | 13028 | 56056193 |
Suspected product quality issue | 10.88 | 9.95 | 8 | 222838 | 204 | 56069017 |
Aphasia | 10.85 | 9.95 | 175 | 222671 | 30240 | 56038981 |
Purple glove syndrome | 10.84 | 9.95 | 8 | 222838 | 205 | 56069016 |
Posterior reversible encephalopathy syndrome | 10.84 | 9.95 | 30 | 222816 | 15930 | 56053291 |
Ventricular hypoplasia | 10.70 | 9.95 | 7 | 222839 | 147 | 56069074 |
Alcohol abuse | 10.66 | 9.95 | 24 | 222822 | 1960 | 56067261 |
Shock haemorrhagic | 10.66 | 9.95 | 12 | 222834 | 9021 | 56060200 |
Pyometra | 10.65 | 9.95 | 6 | 222840 | 95 | 56069126 |
Hepatitis A antibody positive | 10.63 | 9.95 | 5 | 222841 | 53 | 56069168 |
Accommodation disorder | 10.63 | 9.95 | 10 | 222836 | 362 | 56068859 |
Neuropsychiatric symptoms | 10.62 | 9.95 | 13 | 222833 | 638 | 56068583 |
Myocardial infarction | 10.61 | 9.95 | 283 | 222563 | 92587 | 55976634 |
Infective pulmonary exacerbation of cystic fibrosis | 10.57 | 9.95 | 10 | 222836 | 8147 | 56061074 |
Disturbance in sexual arousal | 10.54 | 9.95 | 6 | 222840 | 97 | 56069124 |
Trigger finger | 10.49 | 9.95 | 37 | 222809 | 3916 | 56065305 |
Drug withdrawal syndrome neonatal | 10.41 | 9.95 | 24 | 222822 | 1992 | 56067229 |
Stress | 10.35 | 9.95 | 306 | 222540 | 58604 | 56010617 |
Pericardial effusion | 10.35 | 9.95 | 64 | 222782 | 27111 | 56042110 |
Tongue movement disturbance | 10.29 | 9.95 | 9 | 222837 | 296 | 56068925 |
Hyperventilation | 10.28 | 9.95 | 47 | 222799 | 5601 | 56063620 |
Central nervous system lesion | 10.26 | 9.95 | 71 | 222775 | 9867 | 56059354 |
Bone density decreased | 10.23 | 9.95 | 22 | 222824 | 12738 | 56056483 |
Enuresis | 10.22 | 9.95 | 26 | 222820 | 2297 | 56066924 |
Haemorrhage intracranial | 10.22 | 9.95 | 22 | 222824 | 12733 | 56056488 |
Acute pulmonary oedema | 10.22 | 9.95 | 9 | 222837 | 7588 | 56061633 |
Breast cancer stage II | 10.21 | 9.95 | 5 | 222841 | 5753 | 56063468 |
Poor sucking reflex | 10.20 | 9.95 | 8 | 222838 | 225 | 56068996 |
Intervertebral disc operation | 10.17 | 9.95 | 14 | 222832 | 772 | 56068449 |
Self esteem decreased | 10.14 | 9.95 | 12 | 222834 | 568 | 56068653 |
Adiposis dolorosa | 10.09 | 9.95 | 9 | 222837 | 304 | 56068917 |
Violence-related symptom | 10.01 | 9.95 | 10 | 222836 | 390 | 56068831 |
Unintentional medical device removal | 10.01 | 9.95 | 5 | 222841 | 5689 | 56063532 |
Oesophageal obstruction | 10.01 | 9.95 | 11 | 222835 | 480 | 56068741 |
Serum serotonin increased | 9.99 | 9.95 | 7 | 222839 | 165 | 56069056 |
Device difficult to use | 9.99 | 9.95 | 17 | 222829 | 10744 | 56058477 |
Increased appetite | 9.98 | 9.95 | 64 | 222782 | 8671 | 56060550 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 1278.75 | 11.26 | 688 | 70525 | 18062 | 31608069 |
Dysphoria | 1228.67 | 11.26 | 368 | 70845 | 1804 | 31624327 |
Affect lability | 1153.11 | 11.26 | 392 | 70821 | 3073 | 31623058 |
Suicidal ideation | 766.86 | 11.26 | 643 | 70570 | 35763 | 31590368 |
Irritability | 665.13 | 11.26 | 489 | 70724 | 22400 | 31603731 |
Sensory disturbance | 564.26 | 11.26 | 270 | 70943 | 5477 | 31620654 |
Paraesthesia | 489.37 | 11.26 | 616 | 70597 | 55455 | 31570676 |
Vertigo | 486.31 | 11.26 | 408 | 70805 | 22677 | 31603454 |
Agitation | 472.55 | 11.26 | 595 | 70618 | 53574 | 31572557 |
Anxiety | 457.59 | 11.26 | 770 | 70443 | 90263 | 31535868 |
Insomnia | 443.63 | 11.26 | 777 | 70436 | 94059 | 31532072 |
Hyperhidrosis | 431.30 | 11.26 | 637 | 70576 | 66756 | 31559375 |
Nightmare | 383.62 | 11.26 | 273 | 70940 | 11864 | 31614267 |
Dizziness | 264.49 | 11.26 | 1013 | 70200 | 198134 | 31427997 |
Serotonin syndrome | 255.40 | 11.26 | 260 | 70953 | 18513 | 31607618 |
Tinnitus | 250.32 | 11.26 | 241 | 70972 | 16034 | 31610097 |
Completed suicide | 243.93 | 11.26 | 595 | 70618 | 90919 | 31535212 |
Hypomania | 234.65 | 11.26 | 110 | 71103 | 2125 | 31624006 |
Tremor | 233.25 | 11.26 | 524 | 70689 | 75896 | 31550235 |
Confusional state | 227.42 | 11.26 | 737 | 70476 | 132597 | 31493534 |
Lethargy | 221.08 | 11.26 | 347 | 70866 | 38294 | 31587837 |
Mood swings | 214.07 | 11.26 | 158 | 71055 | 7266 | 31618865 |
Headache | 180.49 | 11.26 | 853 | 70360 | 182799 | 31443332 |
Depression | 178.81 | 11.26 | 528 | 70685 | 90287 | 31535844 |
Nausea | 154.53 | 11.26 | 1200 | 70013 | 306747 | 31319384 |
Suicide attempt | 140.92 | 11.26 | 279 | 70934 | 36969 | 31589162 |
Febrile neutropenia | 140.81 | 11.26 | 49 | 71164 | 121800 | 31504331 |
Sleep disorder | 137.51 | 11.26 | 227 | 70986 | 26121 | 31600010 |
Pyrexia | 126.53 | 11.26 | 313 | 70900 | 303527 | 31322604 |
Fatigue | 106.59 | 11.26 | 1185 | 70028 | 334021 | 31292110 |
Thrombocytopenia | 104.51 | 11.26 | 100 | 71113 | 142647 | 31483484 |
Anger | 104.26 | 11.26 | 127 | 71086 | 11026 | 31615105 |
Acute kidney injury | 100.08 | 11.26 | 310 | 70903 | 279404 | 31346727 |
Withdrawal syndrome | 97.69 | 11.26 | 126 | 71087 | 11591 | 31614540 |
Anaemia | 88.68 | 11.26 | 220 | 70993 | 213302 | 31412829 |
Gastrointestinal tube insertion | 88.04 | 11.26 | 46 | 71167 | 1131 | 31625000 |
Somnolence | 78.57 | 11.26 | 435 | 70778 | 99010 | 31527121 |
Pancytopenia | 73.95 | 11.26 | 53 | 71160 | 87263 | 31538868 |
Fall | 71.80 | 11.26 | 685 | 70528 | 185404 | 31440727 |
Feeling abnormal | 71.23 | 11.26 | 285 | 70928 | 56717 | 31569414 |
Intentional self-injury | 71.18 | 11.26 | 116 | 71097 | 13199 | 31612932 |
Neutropenia | 69.51 | 11.26 | 131 | 71082 | 140233 | 31485898 |
Disturbance in attention | 65.09 | 11.26 | 151 | 71062 | 22299 | 31603832 |
Memory impairment | 63.18 | 11.26 | 209 | 71004 | 37921 | 31588210 |
Sepsis | 62.64 | 11.26 | 157 | 71056 | 151772 | 31474359 |
Sedation | 62.20 | 11.26 | 134 | 71079 | 18831 | 31607300 |
Multiple organ dysfunction syndrome | 59.60 | 11.26 | 40 | 71173 | 68163 | 31557968 |
Dyspnoea | 55.66 | 11.26 | 499 | 70714 | 342980 | 31283151 |
Disease progression | 52.60 | 11.26 | 76 | 71137 | 90388 | 31535743 |
Hepatic enzyme increased | 51.81 | 11.26 | 188 | 71025 | 35720 | 31590411 |
Intentional overdose | 50.93 | 11.26 | 206 | 71007 | 41183 | 31584948 |
Pleural effusion | 50.78 | 11.26 | 56 | 71157 | 74864 | 31551267 |
Antidepressant drug level above therapeutic | 50.25 | 11.26 | 19 | 71194 | 208 | 31625923 |
Haemoglobin decreased | 49.95 | 11.26 | 112 | 71101 | 112563 | 31513568 |
Sexual dysfunction | 49.46 | 11.26 | 64 | 71149 | 5904 | 31620227 |
Loss of consciousness | 47.47 | 11.26 | 317 | 70896 | 77038 | 31549093 |
Urinary retention | 46.50 | 11.26 | 174 | 71039 | 33551 | 31592580 |
Malignant neoplasm progression | 46.28 | 11.26 | 66 | 71147 | 78932 | 31547199 |
Analgesic drug level above therapeutic | 45.24 | 11.26 | 19 | 71194 | 279 | 31625852 |
Blood creatinine increased | 45.06 | 11.26 | 82 | 71131 | 88996 | 31537135 |
Platelet count decreased | 44.81 | 11.26 | 115 | 71098 | 110320 | 31515811 |
Respiratory disorder neonatal | 43.50 | 11.26 | 32 | 71181 | 1463 | 31624668 |
Toxicity to various agents | 42.95 | 11.26 | 608 | 70605 | 180879 | 31445252 |
Ascites | 41.63 | 11.26 | 20 | 71193 | 40993 | 31585138 |
Myoclonus | 41.54 | 11.26 | 95 | 71118 | 13895 | 31612236 |
Migraine | 38.52 | 11.26 | 93 | 71120 | 14087 | 31612044 |
Cardiac failure | 38.44 | 11.26 | 85 | 71128 | 85868 | 31540263 |
Therapy interrupted | 38.40 | 11.26 | 78 | 71135 | 10518 | 31615613 |
General physical health deterioration | 38.13 | 11.26 | 129 | 71084 | 113306 | 31512825 |
Renal failure | 37.66 | 11.26 | 146 | 71067 | 123184 | 31502947 |
Balance disorder | 37.42 | 11.26 | 175 | 71038 | 37247 | 31588884 |
Gastric bypass | 37.14 | 11.26 | 16 | 71197 | 251 | 31625880 |
Pneumonia | 36.27 | 11.26 | 533 | 70680 | 334779 | 31291352 |
Mucosal inflammation | 36.16 | 11.26 | 16 | 71197 | 34411 | 31591720 |
Haemorrhage | 35.95 | 11.26 | 32 | 71181 | 47302 | 31578829 |
Road traffic accident | 35.80 | 11.26 | 99 | 71114 | 16282 | 31609849 |
Respiratory failure | 35.03 | 11.26 | 114 | 71099 | 101335 | 31524796 |
Cytomegalovirus infection | 34.03 | 11.26 | 7 | 71206 | 24700 | 31601431 |
Urinary hesitation | 33.76 | 11.26 | 34 | 71179 | 2387 | 31623744 |
Hallucination, auditory | 33.74 | 11.26 | 73 | 71140 | 10287 | 31615844 |
Drug resistance | 33.67 | 11.26 | 6 | 71207 | 23447 | 31602684 |
Pain | 33.34 | 11.26 | 597 | 70616 | 186162 | 31439969 |
Product use in unapproved indication | 33.17 | 11.26 | 113 | 71100 | 99058 | 31527073 |
Abnormal dreams | 32.79 | 11.26 | 58 | 71155 | 7050 | 31619081 |
Aggression | 32.72 | 11.26 | 168 | 71045 | 37123 | 31589008 |
Reversible airways obstruction | 32.61 | 11.26 | 16 | 71197 | 343 | 31625788 |
C-reactive protein increased | 32.26 | 11.26 | 37 | 71176 | 48613 | 31577518 |
Major depression | 31.24 | 11.26 | 43 | 71170 | 4210 | 31621921 |
Feeling jittery | 30.51 | 11.26 | 40 | 71173 | 3737 | 31622394 |
Overdose | 30.27 | 11.26 | 307 | 70906 | 84357 | 31541774 |
Metabolic acidosis | 29.76 | 11.26 | 27 | 71186 | 39550 | 31586581 |
Hallucination | 29.55 | 11.26 | 192 | 71021 | 46218 | 31579913 |
Mania | 29.13 | 11.26 | 64 | 71149 | 9113 | 31617018 |
Neuropathy peripheral | 28.84 | 11.26 | 278 | 70935 | 75371 | 31550760 |
Hypokalaemia | 28.27 | 11.26 | 48 | 71165 | 53526 | 31572605 |
Renal impairment | 27.79 | 11.26 | 100 | 71113 | 86249 | 31539882 |
Affective disorder | 27.79 | 11.26 | 38 | 71175 | 3698 | 31622433 |
Yawning | 27.39 | 11.26 | 16 | 71197 | 492 | 31625639 |
Surgery | 27.39 | 11.26 | 76 | 71137 | 12523 | 31613608 |
Disorientation | 27.31 | 11.26 | 139 | 71074 | 30605 | 31595526 |
Self esteem decreased | 27.13 | 11.26 | 16 | 71197 | 501 | 31625630 |
Growth hormone deficiency | 26.96 | 11.26 | 13 | 71200 | 268 | 31625863 |
Amnesia | 26.83 | 11.26 | 114 | 71099 | 23288 | 31602843 |
Septic shock | 26.73 | 11.26 | 69 | 71144 | 66089 | 31560042 |
Dehydration | 26.44 | 11.26 | 158 | 71055 | 118953 | 31507178 |
Cough | 26.29 | 11.26 | 186 | 71027 | 134628 | 31491503 |
Leukopenia | 26.00 | 11.26 | 57 | 71156 | 57771 | 31568360 |
Disseminated intravascular coagulation | 25.95 | 11.26 | 7 | 71206 | 20530 | 31605601 |
Bradyphrenia | 25.78 | 11.26 | 40 | 71173 | 4364 | 31621767 |
Agranulocytosis | 25.46 | 11.26 | 8 | 71205 | 21239 | 31604892 |
White blood cell count decreased | 25.06 | 11.26 | 106 | 71107 | 87292 | 31538839 |
Bone marrow failure | 25.03 | 11.26 | 16 | 71197 | 27992 | 31598139 |
Off label use | 24.76 | 11.26 | 593 | 70620 | 346681 | 31279450 |
Electric shock sensation | 24.71 | 11.26 | 9 | 71204 | 88 | 31626043 |
Atrial fibrillation | 24.69 | 11.26 | 152 | 71061 | 113631 | 31512500 |
Fibromyalgia | 24.51 | 11.26 | 31 | 71182 | 2795 | 31623336 |
Initial insomnia | 23.80 | 11.26 | 31 | 71182 | 2878 | 31623253 |
Drug hypersensitivity | 23.02 | 11.26 | 257 | 70956 | 72342 | 31553789 |
Abnormal behaviour | 22.78 | 11.26 | 110 | 71103 | 23718 | 31602413 |
International normalised ratio increased | 22.52 | 11.26 | 42 | 71171 | 45181 | 31580950 |
Acute myeloid leukaemia | 22.42 | 11.26 | 7 | 71206 | 18665 | 31607466 |
Neuralgia | 22.35 | 11.26 | 68 | 71145 | 11798 | 31614333 |
Post concussion syndrome | 22.15 | 11.26 | 9 | 71204 | 121 | 31626010 |
Psychotic disorder | 22.10 | 11.26 | 104 | 71109 | 22189 | 31603942 |
Convulsive threshold lowered | 22.06 | 11.26 | 14 | 71199 | 501 | 31625630 |
Hypertensive emergency | 22.06 | 11.26 | 18 | 71195 | 960 | 31625171 |
Homicidal ideation | 21.81 | 11.26 | 28 | 71185 | 2563 | 31623568 |
Hepatitis E antibody positive | 21.60 | 11.26 | 11 | 71202 | 256 | 31625875 |
Depressed mood | 21.23 | 11.26 | 87 | 71126 | 17488 | 31608643 |
Dystonia | 20.59 | 11.26 | 60 | 71153 | 10165 | 31615966 |
Hepatitis E virus test positive | 20.57 | 11.26 | 11 | 71202 | 284 | 31625847 |
Interstitial lung disease | 20.50 | 11.26 | 70 | 71143 | 61333 | 31564798 |
Agitation neonatal | 20.46 | 11.26 | 18 | 71195 | 1065 | 31625066 |
Colitis ulcerative | 20.44 | 11.26 | 8 | 71205 | 18521 | 31607610 |
Hypocalcaemia | 20.41 | 11.26 | 12 | 71201 | 21966 | 31604165 |
Delirium | 20.35 | 11.26 | 161 | 71052 | 41260 | 31584871 |
Gastrointestinal adenocarcinoma | 20.34 | 11.26 | 7 | 71206 | 57 | 31626074 |
Liver function test abnormal | 20.23 | 11.26 | 125 | 71088 | 29567 | 31596564 |
Erectile dysfunction | 20.00 | 11.26 | 91 | 71122 | 19144 | 31606987 |
Pneumocystis jirovecii pneumonia | 19.94 | 11.26 | 8 | 71205 | 18243 | 31607888 |
Muscle spasticity | 19.85 | 11.26 | 41 | 71172 | 5594 | 31620537 |
Acute stress disorder | 19.77 | 11.26 | 9 | 71204 | 162 | 31625969 |
Cardiogenic shock | 19.75 | 11.26 | 13 | 71200 | 22395 | 31603736 |
Haemoptysis | 19.74 | 11.26 | 26 | 71187 | 32163 | 31593968 |
Somnambulism | 19.70 | 11.26 | 28 | 71185 | 2824 | 31623307 |
Complex regional pain syndrome | 19.61 | 11.26 | 13 | 71200 | 502 | 31625629 |
Undifferentiated connective tissue disease | 19.60 | 11.26 | 6 | 71207 | 32 | 31626099 |
Pneumonitis | 19.58 | 11.26 | 24 | 71189 | 30628 | 31595503 |
Prostate cancer | 19.55 | 11.26 | 34 | 71179 | 37567 | 31588564 |
Infusion related reaction | 19.50 | 11.26 | 50 | 71163 | 48005 | 31578126 |
Cardiac failure congestive | 19.40 | 11.26 | 102 | 71111 | 79285 | 31546846 |
Clonus | 19.31 | 11.26 | 26 | 71187 | 2493 | 31623638 |
Oedema peripheral | 19.29 | 11.26 | 156 | 71057 | 109683 | 31516448 |
Toxic epidermal necrolysis | 19.09 | 11.26 | 10 | 71203 | 19514 | 31606617 |
Myocardial infarction | 19.08 | 11.26 | 163 | 71050 | 113291 | 31512840 |
Neutrophil count decreased | 19.03 | 11.26 | 48 | 71165 | 46346 | 31579785 |
Multiple sclerosis relapse | 19.02 | 11.26 | 65 | 71148 | 11982 | 31614149 |
Rash maculo-papular | 18.80 | 11.26 | 18 | 71195 | 25701 | 31600430 |
Rash | 18.79 | 11.26 | 329 | 70884 | 201157 | 31424974 |
Erythema | 18.71 | 11.26 | 105 | 71108 | 80300 | 31545831 |
Respiratory distress | 18.69 | 11.26 | 29 | 71184 | 33524 | 31592607 |
Lacunar stroke | 18.69 | 11.26 | 9 | 71204 | 185 | 31625946 |
Productive cough | 18.68 | 11.26 | 29 | 71184 | 33511 | 31592620 |
Drug reaction with eosinophilia and systemic symptoms | 18.66 | 11.26 | 24 | 71189 | 29994 | 31596137 |
Pericardial effusion | 18.46 | 11.26 | 14 | 71199 | 22409 | 31603722 |
Hypersomnia | 18.45 | 11.26 | 61 | 71152 | 11058 | 31615073 |
Wrong drug | 18.40 | 11.26 | 7 | 71206 | 78 | 31626053 |
Dysmetropsia | 18.17 | 11.26 | 4 | 71209 | 3 | 31626128 |
Neutropenic sepsis | 18.14 | 11.26 | 3 | 71210 | 12376 | 31613755 |
Apathy | 18.13 | 11.26 | 43 | 71170 | 6439 | 31619692 |
Lymphopenia | 17.89 | 11.26 | 5 | 71208 | 14324 | 31611807 |
Sleep sex | 17.64 | 11.26 | 4 | 71209 | 4 | 31626127 |
Gait disturbance | 17.63 | 11.26 | 258 | 70955 | 77237 | 31548894 |
Acute myocardial infarction | 17.61 | 11.26 | 57 | 71156 | 50766 | 31575365 |
Sleep-related eating disorder | 17.55 | 11.26 | 10 | 71203 | 293 | 31625838 |
Compulsive shopping | 17.43 | 11.26 | 11 | 71202 | 390 | 31625741 |
Haematochezia | 17.28 | 11.26 | 41 | 71172 | 40423 | 31585708 |
Steatohepatitis | 17.25 | 11.26 | 10 | 71203 | 303 | 31625828 |
Cytokine release syndrome | 17.06 | 11.26 | 8 | 71205 | 16634 | 31609497 |
Drug interaction | 17.05 | 11.26 | 600 | 70613 | 207943 | 31418188 |
Feeling guilty | 17.02 | 11.26 | 10 | 71203 | 311 | 31625820 |
Gastrointestinal haemorrhage | 17.01 | 11.26 | 112 | 71101 | 82437 | 31543694 |
Therapy cessation | 16.99 | 11.26 | 73 | 71140 | 14982 | 31611149 |
Treatment failure | 16.89 | 11.26 | 42 | 71171 | 40750 | 31585381 |
Tardive dyskinesia | 16.78 | 11.26 | 38 | 71175 | 5521 | 31620610 |
Thinking abnormal | 16.71 | 11.26 | 38 | 71175 | 5535 | 31620596 |
Pulmonary embolism | 16.71 | 11.26 | 111 | 71102 | 81535 | 31544596 |
Haematuria | 16.71 | 11.26 | 51 | 71162 | 46263 | 31579868 |
Neonatal tachypnoea | 16.59 | 11.26 | 8 | 71205 | 165 | 31625966 |
Forced expiratory flow decreased | 16.54 | 11.26 | 8 | 71205 | 166 | 31625965 |
Coronary artery disease | 16.45 | 11.26 | 51 | 71162 | 46036 | 31580095 |
Tumour lysis syndrome | 16.39 | 11.26 | 7 | 71206 | 15378 | 31610753 |
Seizure | 16.39 | 11.26 | 315 | 70898 | 99453 | 31526678 |
Paedophilia | 16.37 | 11.26 | 4 | 71209 | 7 | 31626124 |
Blood lactate dehydrogenase increased | 16.36 | 11.26 | 13 | 71200 | 20326 | 31605805 |
Mental disorder | 16.33 | 11.26 | 68 | 71145 | 13766 | 31612365 |
Restlessness | 16.33 | 11.26 | 99 | 71114 | 23262 | 31602869 |
Intentional product misuse | 16.23 | 11.26 | 143 | 71070 | 37808 | 31588323 |
Product used for unknown indication | 16.13 | 11.26 | 14 | 71199 | 813 | 31625318 |
Nephropathy toxic | 16.09 | 11.26 | 3 | 71210 | 11350 | 31614781 |
Angioedema | 16.06 | 11.26 | 32 | 71181 | 33586 | 31592545 |
Stomatitis | 16.03 | 11.26 | 41 | 71172 | 39397 | 31586734 |
Prescribed overdose | 15.76 | 11.26 | 51 | 71162 | 9141 | 31616990 |
Adenocarcinoma of appendix | 15.74 | 11.26 | 7 | 71206 | 119 | 31626012 |
Cholestasis | 15.63 | 11.26 | 20 | 71193 | 25055 | 31601076 |
Pulmonary fibrosis | 15.61 | 11.26 | 9 | 71204 | 16651 | 31609480 |
Orgasm abnormal | 15.38 | 11.26 | 7 | 71206 | 126 | 31626005 |
Neonatal hyponatraemia | 15.30 | 11.26 | 6 | 71207 | 73 | 31626058 |
Libido decreased | 15.30 | 11.26 | 32 | 71181 | 4404 | 31621727 |
Psychomotor hyperactivity | 15.29 | 11.26 | 49 | 71164 | 8738 | 31617393 |
Delirium tremens | 15.25 | 11.26 | 12 | 71201 | 607 | 31625524 |
Hyperlipasaemia | 15.14 | 11.26 | 11 | 71202 | 493 | 31625638 |
Palmar-plantar erythrodysaesthesia syndrome | 15.03 | 11.26 | 8 | 71205 | 15475 | 31610656 |
Ventricular hypoplasia | 15.01 | 11.26 | 6 | 71207 | 77 | 31626054 |
Nephrolithiasis | 14.96 | 11.26 | 109 | 71104 | 27230 | 31598901 |
Cerebral infarction | 14.91 | 11.26 | 22 | 71191 | 25955 | 31600176 |
Drug screen positive | 14.73 | 11.26 | 29 | 71184 | 3823 | 31622308 |
Tubulointerstitial nephritis | 14.66 | 11.26 | 12 | 71201 | 18484 | 31607647 |
Urethral discharge | 14.64 | 11.26 | 4 | 71209 | 13 | 31626118 |
Hypotension | 14.64 | 11.26 | 349 | 70864 | 204269 | 31421862 |
Angina pectoris | 14.34 | 11.26 | 28 | 71185 | 29613 | 31596518 |
Rhabdomyolysis | 14.27 | 11.26 | 84 | 71129 | 63497 | 31562634 |
Inappropriate antidiuretic hormone secretion | 14.25 | 11.26 | 57 | 71156 | 11330 | 31614801 |
Dyskinesia | 14.22 | 11.26 | 88 | 71125 | 20822 | 31605309 |
Bipolar disorder | 14.19 | 11.26 | 28 | 71185 | 3696 | 31622435 |
Restless legs syndrome | 14.19 | 11.26 | 44 | 71169 | 7712 | 31618419 |
Speech sound disorder | 14.10 | 11.26 | 7 | 71206 | 154 | 31625977 |
Abdominal pain | 14.02 | 11.26 | 237 | 70976 | 145715 | 31480416 |
Drug screen false positive | 13.92 | 11.26 | 12 | 71201 | 691 | 31625440 |
Hypoxia | 13.82 | 11.26 | 62 | 71151 | 50251 | 31575880 |
Bladder cancer | 13.73 | 11.26 | 8 | 71205 | 14717 | 31611414 |
Epistaxis | 13.68 | 11.26 | 68 | 71145 | 53639 | 31572492 |
Influenza like illness | 13.68 | 11.26 | 101 | 71112 | 25336 | 31600795 |
Tethered cord syndrome | 13.62 | 11.26 | 4 | 71209 | 18 | 31626113 |
Chills | 13.62 | 11.26 | 104 | 71109 | 74046 | 31552085 |
Blood urea increased | 13.53 | 11.26 | 28 | 71185 | 28984 | 31597147 |
Muscle twitching | 13.52 | 11.26 | 45 | 71168 | 8185 | 31617946 |
Retrograde ejaculation | 13.52 | 11.26 | 9 | 71204 | 350 | 31625781 |
Stiff person syndrome | 13.49 | 11.26 | 6 | 71207 | 102 | 31626029 |
Drug tolerance | 13.48 | 11.26 | 22 | 71191 | 2505 | 31623626 |
Narcissistic personality disorder | 13.45 | 11.26 | 4 | 71209 | 19 | 31626112 |
Axillary pain | 13.40 | 11.26 | 9 | 71204 | 355 | 31625776 |
Psychopathic personality | 13.23 | 11.26 | 3 | 71210 | 3 | 31626128 |
Melaena | 13.23 | 11.26 | 34 | 71179 | 32620 | 31593511 |
Loss of employment | 13.20 | 11.26 | 10 | 71203 | 478 | 31625653 |
Ileus | 13.10 | 11.26 | 9 | 71204 | 15160 | 31610971 |
Ureteric haemorrhage | 13.08 | 11.26 | 6 | 71207 | 110 | 31626021 |
Suicidal behaviour | 12.88 | 11.26 | 16 | 71197 | 1416 | 31624715 |
Ventricular fibrillation | 12.86 | 11.26 | 14 | 71199 | 18834 | 31607297 |
Intentional product use issue | 12.85 | 11.26 | 62 | 71151 | 49285 | 31576846 |
Homicide | 12.83 | 11.26 | 13 | 71200 | 919 | 31625212 |
Depression suicidal | 12.68 | 11.26 | 17 | 71196 | 1623 | 31624508 |
Hyperglycaemia | 12.57 | 11.26 | 41 | 71172 | 36435 | 31589696 |
Paranoia | 12.55 | 11.26 | 52 | 71161 | 10503 | 31615628 |
Pseudomonas infection | 12.45 | 11.26 | 5 | 71208 | 11396 | 31614735 |
Chest injury | 12.45 | 11.26 | 16 | 71197 | 1466 | 31624665 |
Graft versus host disease | 12.40 | 11.26 | 4 | 71209 | 10443 | 31615688 |
Lymphadenopathy | 12.36 | 11.26 | 25 | 71188 | 26096 | 31600035 |
Dissociation | 12.35 | 11.26 | 15 | 71198 | 1297 | 31624834 |
Facial spasm | 12.35 | 11.26 | 7 | 71206 | 203 | 31625928 |
Brief psychotic disorder with marked stressors | 12.29 | 11.26 | 7 | 71206 | 205 | 31625926 |
Alcoholism | 12.29 | 11.26 | 25 | 71188 | 3374 | 31622757 |
Mood altered | 12.29 | 11.26 | 44 | 71169 | 8302 | 31617829 |
Hyperreflexia | 12.25 | 11.26 | 23 | 71190 | 2926 | 31623205 |
Deep vein thrombosis | 12.21 | 11.26 | 83 | 71130 | 60653 | 31565478 |
Autonomic dysreflexia | 12.19 | 11.26 | 5 | 71208 | 69 | 31626062 |
Helplessness | 12.12 | 11.26 | 5 | 71208 | 70 | 31626061 |
Inflammation | 12.08 | 11.26 | 24 | 71189 | 25217 | 31600914 |
Peritonitis | 12.07 | 11.26 | 10 | 71203 | 15317 | 31610814 |
Snoring | 12.07 | 11.26 | 23 | 71190 | 2960 | 31623171 |
Selective eating disorder | 12.05 | 11.26 | 17 | 71196 | 1703 | 31624428 |
Central nervous system stimulation | 12.02 | 11.26 | 3 | 71210 | 6 | 31626125 |
Plasma cell myeloma | 12.00 | 11.26 | 76 | 71137 | 56455 | 31569676 |
Dry mouth | 11.97 | 11.26 | 95 | 71118 | 24363 | 31601768 |
Aplastic anaemia | 11.89 | 11.26 | 3 | 71210 | 9200 | 31616931 |
Drug eruption | 11.87 | 11.26 | 14 | 71199 | 18173 | 31607958 |
Abdominal compartment syndrome | 11.86 | 11.26 | 12 | 71201 | 847 | 31625284 |
Concussion | 11.82 | 11.26 | 19 | 71194 | 2136 | 31623995 |
Blue toe syndrome | 11.81 | 11.26 | 6 | 71207 | 139 | 31625992 |
Neoplasm progression | 11.80 | 11.26 | 17 | 71196 | 20255 | 31605876 |
Hypoalbuminaemia | 11.78 | 11.26 | 5 | 71208 | 11023 | 31615108 |
Pre-existing condition improved | 11.75 | 11.26 | 20 | 71193 | 2357 | 31623774 |
Reflexes abnormal | 11.64 | 11.26 | 8 | 71205 | 328 | 31625803 |
Lymphoma | 11.62 | 11.26 | 5 | 71208 | 10938 | 31615193 |
Depersonalisation/derealisation disorder | 11.59 | 11.26 | 10 | 71203 | 576 | 31625555 |
Panic disorder | 11.55 | 11.26 | 14 | 71199 | 1208 | 31624923 |
Disease recurrence | 11.51 | 11.26 | 15 | 71198 | 18646 | 31607485 |
Slow speech | 11.51 | 11.26 | 13 | 71200 | 1041 | 31625090 |
Cyanosis | 11.49 | 11.26 | 6 | 71207 | 11729 | 31614402 |
Bradycardia | 11.47 | 11.26 | 100 | 71113 | 69227 | 31556904 |
Asthma | 11.41 | 11.26 | 53 | 71160 | 42558 | 31583573 |
Lung disorder | 11.35 | 11.26 | 36 | 71177 | 32276 | 31593855 |
Myelodysplastic syndrome | 11.35 | 11.26 | 16 | 71197 | 19235 | 31606896 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 980.77 | 9.71 | 790 | 204808 | 31925 | 70690921 |
Suicidal ideation | 815.34 | 9.71 | 1007 | 204591 | 68589 | 70654257 |
Serotonin syndrome | 795.35 | 9.71 | 783 | 204815 | 41331 | 70681515 |
Completed suicide | 511.09 | 9.71 | 1633 | 203965 | 225502 | 70497344 |
Depression | 494.41 | 9.71 | 1481 | 204117 | 197493 | 70525353 |
Hyperhidrosis | 490.98 | 9.71 | 1140 | 204458 | 130446 | 70592400 |
Dysphoria | 478.06 | 9.71 | 242 | 205356 | 4256 | 70718590 |
Anxiety | 471.23 | 9.71 | 1557 | 204041 | 218773 | 70504073 |
Affect lability | 400.97 | 9.71 | 289 | 205309 | 9857 | 70712989 |
Irritability | 373.69 | 9.71 | 506 | 205092 | 37719 | 70685127 |
Tremor | 328.18 | 9.71 | 1095 | 204503 | 154529 | 70568317 |
Nightmare | 326.71 | 9.71 | 361 | 205237 | 21795 | 70701051 |
Febrile neutropenia | 299.33 | 9.71 | 109 | 205489 | 204209 | 70518637 |
Agitation | 285.62 | 9.71 | 750 | 204848 | 92625 | 70630221 |
Insomnia | 263.45 | 9.71 | 1289 | 204309 | 216517 | 70506329 |
Suicide attempt | 249.67 | 9.71 | 645 | 204953 | 78865 | 70643981 |
Dizziness | 244.68 | 9.71 | 2231 | 203367 | 461910 | 70260936 |
Feeling abnormal | 231.05 | 9.71 | 920 | 204678 | 141399 | 70581447 |
Somnolence | 228.66 | 9.71 | 1230 | 204368 | 214376 | 70508470 |
Thrombocytopenia | 228.17 | 9.71 | 214 | 205384 | 238896 | 70483950 |
Stubbornness | 227.02 | 9.71 | 70 | 205528 | 282 | 70722564 |
Pemphigus | 220.44 | 9.71 | 4 | 205594 | 83032 | 70639814 |
Withdrawal syndrome | 214.09 | 9.71 | 310 | 205288 | 24594 | 70698252 |
Paraesthesia | 209.71 | 9.71 | 907 | 204691 | 144630 | 70578216 |
Neutropenia | 206.91 | 9.71 | 265 | 205333 | 256891 | 70465955 |
Pyrexia | 205.05 | 9.71 | 984 | 204614 | 605968 | 70116878 |
Vertigo | 204.77 | 9.71 | 516 | 205082 | 62127 | 70660719 |
Sensory disturbance | 199.83 | 9.71 | 223 | 205375 | 13609 | 70709237 |
Mood swings | 193.98 | 9.71 | 252 | 205346 | 18034 | 70704812 |
Fall | 187.92 | 9.71 | 2040 | 203558 | 442056 | 70280790 |
Anaemia | 180.04 | 9.71 | 585 | 205013 | 402838 | 70320008 |
Acute kidney injury | 174.16 | 9.71 | 746 | 204852 | 473878 | 70248968 |
Pancytopenia | 173.53 | 9.71 | 112 | 205486 | 150995 | 70571851 |
Headache | 163.95 | 9.71 | 2474 | 203124 | 577931 | 70144915 |
Mood altered | 162.36 | 9.71 | 219 | 205379 | 16256 | 70706590 |
Pericarditis | 156.85 | 9.71 | 28 | 205570 | 84677 | 70638169 |
Nausea | 151.28 | 9.71 | 3377 | 202221 | 848711 | 69874135 |
Fibromyalgia | 147.80 | 9.71 | 386 | 205212 | 47488 | 70675358 |
Crying | 147.15 | 9.71 | 239 | 205359 | 20960 | 70701886 |
Intentional self-injury | 146.10 | 9.71 | 299 | 205299 | 31351 | 70691495 |
Migraine | 145.67 | 9.71 | 501 | 205097 | 71737 | 70651109 |
Hand deformity | 144.93 | 9.71 | 36 | 205562 | 86446 | 70636400 |
Glossodynia | 143.02 | 9.71 | 37 | 205561 | 86450 | 70636396 |
Synovitis | 140.08 | 9.71 | 102 | 205496 | 129126 | 70593720 |
Anger | 131.70 | 9.71 | 196 | 205402 | 15936 | 70706910 |
Tinnitus | 130.98 | 9.71 | 310 | 205288 | 35866 | 70686980 |
Memory impairment | 130.80 | 9.71 | 574 | 205024 | 92067 | 70630779 |
Thinking abnormal | 129.26 | 9.71 | 167 | 205431 | 11884 | 70710962 |
Disturbance in attention | 126.48 | 9.71 | 340 | 205258 | 42554 | 70680292 |
Duodenal ulcer perforation | 126.26 | 9.71 | 5 | 205593 | 51107 | 70671739 |
Confusional state | 123.56 | 9.71 | 1314 | 204284 | 283084 | 70439762 |
Inappropriate antidiuretic hormone secretion | 117.16 | 9.71 | 228 | 205370 | 23048 | 70699798 |
Contraindicated product administered | 114.21 | 9.71 | 133 | 205465 | 134479 | 70588367 |
Affective disorder | 112.21 | 9.71 | 123 | 205475 | 7356 | 70715490 |
Malignant neoplasm progression | 111.34 | 9.71 | 113 | 205485 | 121626 | 70601220 |
Loss of consciousness | 110.68 | 9.71 | 802 | 204796 | 154914 | 70567932 |
Platelet count decreased | 109.02 | 9.71 | 220 | 205378 | 178002 | 70544844 |
Depressed mood | 107.45 | 9.71 | 325 | 205273 | 43495 | 70679351 |
Sepsis | 107.29 | 9.71 | 357 | 205241 | 244188 | 70478658 |
Cardiac failure | 105.25 | 9.71 | 158 | 205440 | 143383 | 70579463 |
Drug interaction | 100.17 | 9.71 | 1607 | 203991 | 379834 | 70343012 |
Electric shock | 97.79 | 9.71 | 54 | 205544 | 1141 | 70721705 |
Product substitution issue | 97.67 | 9.71 | 185 | 205413 | 18328 | 70704518 |
Disease progression | 95.30 | 9.71 | 194 | 205404 | 156478 | 70566368 |
Systemic lupus erythematosus | 95.00 | 9.71 | 93 | 205505 | 101809 | 70621037 |
Therapy interrupted | 94.67 | 9.71 | 217 | 205381 | 24585 | 70698261 |
Abnormal behaviour | 93.29 | 9.71 | 266 | 205332 | 34443 | 70688403 |
General physical health deterioration | 93.27 | 9.71 | 360 | 205238 | 235671 | 70487175 |
Toxicity to various agents | 92.93 | 9.71 | 1590 | 204008 | 380582 | 70342264 |
Multiple sclerosis relapse | 92.58 | 9.71 | 305 | 205293 | 42712 | 70680134 |
Pain | 92.11 | 9.71 | 2429 | 203169 | 626387 | 70096459 |
Hypomania | 91.34 | 9.71 | 100 | 205498 | 5972 | 70716874 |
Coordination abnormal | 90.33 | 9.71 | 165 | 205433 | 15901 | 70706945 |
Septic shock | 88.83 | 9.71 | 117 | 205481 | 112141 | 70610705 |
C-reactive protein abnormal | 88.30 | 9.71 | 6 | 205592 | 38573 | 70684273 |
Folliculitis | 88.30 | 9.71 | 10 | 205588 | 42560 | 70680286 |
Anti-cyclic citrullinated peptide antibody positive | 84.75 | 9.71 | 49 | 205549 | 70136 | 70652710 |
Blood creatinine increased | 84.50 | 9.71 | 180 | 205418 | 142821 | 70580025 |
Tardive dyskinesia | 84.46 | 9.71 | 123 | 205475 | 9806 | 70713040 |
Multiple organ dysfunction syndrome | 83.93 | 9.71 | 115 | 205483 | 108400 | 70614446 |
Sleep disorder due to general medical condition, insomnia type | 83.45 | 9.71 | 5 | 205593 | 35727 | 70687119 |
Urinary retention | 81.53 | 9.71 | 335 | 205263 | 52185 | 70670661 |
Off label use | 81.12 | 9.71 | 1593 | 204005 | 741467 | 69981379 |
Ascites | 80.37 | 9.71 | 48 | 205550 | 67499 | 70655347 |
Renal failure | 80.18 | 9.71 | 280 | 205318 | 188790 | 70534056 |
Infusion related reaction | 80.16 | 9.71 | 298 | 205300 | 197236 | 70525610 |
Drug reaction with eosinophilia and systemic symptoms | 79.85 | 9.71 | 34 | 205564 | 57979 | 70664867 |
Restless legs syndrome | 79.10 | 9.71 | 169 | 205429 | 18259 | 70704587 |
Wound | 78.01 | 9.71 | 103 | 205495 | 98629 | 70624217 |
Treatment failure | 77.44 | 9.71 | 191 | 205407 | 143951 | 70578895 |
Somatic symptom disorder | 76.06 | 9.71 | 56 | 205542 | 1974 | 70720872 |
Hallucination | 74.63 | 9.71 | 426 | 205172 | 75834 | 70647012 |
Mucosal inflammation | 74.23 | 9.71 | 53 | 205545 | 67797 | 70655049 |
Post-traumatic stress disorder | 74.10 | 9.71 | 77 | 205521 | 4330 | 70718516 |
Reversible cerebral vasoconstriction syndrome | 72.39 | 9.71 | 61 | 205537 | 2624 | 70720222 |
Intentional overdose | 72.23 | 9.71 | 511 | 205087 | 97924 | 70624922 |
Renal impairment | 71.02 | 9.71 | 199 | 205399 | 143738 | 70579108 |
Panic attack | 70.99 | 9.71 | 181 | 205417 | 21938 | 70700908 |
Personality disorder | 70.96 | 9.71 | 84 | 205514 | 5464 | 70717382 |
Balance disorder | 70.33 | 9.71 | 475 | 205123 | 89653 | 70633193 |
Surgery | 70.32 | 9.71 | 219 | 205379 | 29770 | 70693076 |
Cytomegalovirus infection | 69.69 | 9.71 | 15 | 205583 | 39743 | 70683103 |
Drug hypersensitivity | 69.65 | 9.71 | 1108 | 204490 | 261351 | 70461495 |
Alopecia | 69.56 | 9.71 | 317 | 205281 | 198173 | 70524673 |
Therapy cessation | 69.12 | 9.71 | 235 | 205363 | 33441 | 70689405 |
Pleural effusion | 67.56 | 9.71 | 181 | 205417 | 132683 | 70590163 |
Amnesia | 66.75 | 9.71 | 314 | 205284 | 51841 | 70671005 |
Muscle injury | 66.50 | 9.71 | 15 | 205583 | 38479 | 70684367 |
Discomfort | 66.30 | 9.71 | 128 | 205470 | 105308 | 70617538 |
Hypersensitivity | 65.94 | 9.71 | 393 | 205205 | 229419 | 70493427 |
Nasal turbinate hypertrophy | 65.30 | 9.71 | 33 | 205565 | 578 | 70722268 |
Mania | 65.25 | 9.71 | 150 | 205448 | 17024 | 70705822 |
Sopor | 63.13 | 9.71 | 217 | 205381 | 31050 | 70691796 |
Arthropathy | 63.09 | 9.71 | 223 | 205375 | 149834 | 70573012 |
Leukopenia | 63.05 | 9.71 | 134 | 205464 | 106426 | 70616420 |
Coma | 62.90 | 9.71 | 469 | 205129 | 91375 | 70631471 |
Bone marrow failure | 62.40 | 9.71 | 32 | 205566 | 48978 | 70673868 |
Neutrophil count decreased | 62.18 | 9.71 | 91 | 205507 | 83465 | 70639381 |
Fatigue | 62.13 | 9.71 | 2951 | 202647 | 821368 | 69901478 |
Rash | 62.01 | 9.71 | 1074 | 204524 | 509488 | 70213358 |
Mental disorder | 61.45 | 9.71 | 201 | 205397 | 28039 | 70694807 |
Lower respiratory tract infection | 61.12 | 9.71 | 147 | 205451 | 111766 | 70611080 |
Maternal exposure during pregnancy | 61.04 | 9.71 | 154 | 205444 | 115191 | 70607655 |
Pneumonia aspiration | 60.31 | 9.71 | 347 | 205251 | 61942 | 70660904 |
Rubber sensitivity | 60.02 | 9.71 | 43 | 205555 | 1452 | 70721394 |
Haemoglobin decreased | 59.83 | 9.71 | 349 | 205249 | 204810 | 70518036 |
Abnormal dreams | 59.74 | 9.71 | 109 | 205489 | 10494 | 70712352 |
Atrial fibrillation | 59.59 | 9.71 | 303 | 205295 | 184045 | 70538801 |
Neutropenic sepsis | 59.45 | 9.71 | 3 | 205595 | 24827 | 70698019 |
Weight increased | 58.72 | 9.71 | 1008 | 204590 | 241323 | 70481523 |
Oesophageal spasm | 58.66 | 9.71 | 58 | 205540 | 3073 | 70719773 |
Coma blister | 58.53 | 9.71 | 23 | 205575 | 213 | 70722633 |
Dry mouth | 58.40 | 9.71 | 377 | 205221 | 70080 | 70652766 |
Neck deformity | 58.05 | 9.71 | 45 | 205553 | 1716 | 70721130 |
Multiple sclerosis | 57.77 | 9.71 | 183 | 205415 | 25102 | 70697744 |
Colitis microscopic | 57.76 | 9.71 | 98 | 205500 | 8907 | 70713939 |
Hypocalcaemia | 57.54 | 9.71 | 29 | 205569 | 44830 | 70678016 |
Gastric bypass | 57.39 | 9.71 | 38 | 205560 | 1126 | 70721720 |
Gastrointestinal tube insertion | 57.26 | 9.71 | 42 | 205556 | 1472 | 70721374 |
Drug intolerance | 57.08 | 9.71 | 401 | 205197 | 225286 | 70497560 |
Interstitial lung disease | 55.99 | 9.71 | 139 | 205459 | 104546 | 70618300 |
Hyperreflexia | 55.91 | 9.71 | 87 | 205511 | 7355 | 70715491 |
Influenza like illness | 55.65 | 9.71 | 352 | 205246 | 64979 | 70657867 |
Lethargy | 55.40 | 9.71 | 391 | 205207 | 74859 | 70647987 |
Dyspnoea | 55.15 | 9.71 | 1757 | 203841 | 768303 | 69954543 |
Bronchial neoplasm | 54.68 | 9.71 | 27 | 205571 | 449 | 70722397 |
Hallucination, visual | 54.41 | 9.71 | 198 | 205400 | 29139 | 70693707 |
Disorientation | 54.34 | 9.71 | 320 | 205278 | 57603 | 70665243 |
Blister | 54.14 | 9.71 | 133 | 205465 | 100393 | 70622453 |
Vision blurred | 54.11 | 9.71 | 465 | 205133 | 94519 | 70628327 |
Stomatitis | 54.00 | 9.71 | 191 | 205407 | 128320 | 70594526 |
Product dose omission issue | 53.56 | 9.71 | 907 | 204691 | 216561 | 70506285 |
Joint swelling | 52.00 | 9.71 | 476 | 205122 | 252735 | 70470111 |
Dyskinesia | 51.62 | 9.71 | 246 | 205352 | 40828 | 70682018 |
Sleep disorder | 51.40 | 9.71 | 363 | 205235 | 69509 | 70653337 |
Lymphocytic oesophagitis | 51.35 | 9.71 | 13 | 205585 | 19 | 70722827 |
Extremity contracture | 49.53 | 9.71 | 40 | 205558 | 1620 | 70721226 |
Clonus | 49.51 | 9.71 | 75 | 205523 | 6193 | 70716653 |
Pneumonia | 49.49 | 9.71 | 1333 | 204265 | 594899 | 70127947 |
Libido increased | 49.44 | 9.71 | 42 | 205556 | 1827 | 70721019 |
Bronchopulmonary aspergillosis | 48.86 | 9.71 | 3 | 205595 | 20999 | 70701847 |
Erythema | 48.80 | 9.71 | 358 | 205240 | 199205 | 70523641 |
Drug resistance | 48.52 | 9.71 | 25 | 205573 | 38165 | 70684681 |
Hot flush | 48.51 | 9.71 | 277 | 205321 | 49307 | 70673539 |
Oedema peripheral | 48.49 | 9.71 | 425 | 205173 | 227666 | 70495180 |
Swelling | 48.16 | 9.71 | 334 | 205264 | 188205 | 70534641 |
Blood pressure increased | 48.15 | 9.71 | 791 | 204807 | 187726 | 70535120 |
Major depression | 48.13 | 9.71 | 88 | 205510 | 8486 | 70714360 |
Endometrial ablation | 47.78 | 9.71 | 30 | 205568 | 810 | 70722036 |
Hyperaesthesia | 47.71 | 9.71 | 101 | 205497 | 10841 | 70712005 |
Respiratory failure | 47.62 | 9.71 | 290 | 205308 | 168445 | 70554401 |
Helicobacter infection | 47.17 | 9.71 | 55 | 205543 | 55601 | 70667245 |
Stiff person syndrome | 46.29 | 9.71 | 22 | 205576 | 335 | 70722511 |
Hyperkalaemia | 45.06 | 9.71 | 158 | 205440 | 106433 | 70616413 |
Muscle twitching | 44.84 | 9.71 | 143 | 205455 | 19684 | 70703162 |
Rheumatoid factor positive | 44.15 | 9.71 | 45 | 205553 | 48355 | 70674491 |
Cardiac failure congestive | 43.56 | 9.71 | 223 | 205375 | 135234 | 70587612 |
White blood cell count decreased | 43.16 | 9.71 | 302 | 205296 | 169839 | 70553007 |
Product use in unapproved indication | 43.03 | 9.71 | 389 | 205209 | 207089 | 70515757 |
Intentional product misuse | 42.91 | 9.71 | 385 | 205213 | 79210 | 70643636 |
Acute myeloid leukaemia | 42.79 | 9.71 | 18 | 205580 | 30922 | 70691924 |
Neurologic neglect syndrome | 42.57 | 9.71 | 43 | 205555 | 2338 | 70720508 |
Restlessness | 42.30 | 9.71 | 237 | 205361 | 41891 | 70680955 |
Coronary artery disease | 42.25 | 9.71 | 73 | 205525 | 62663 | 70660183 |
Temperature intolerance | 42.14 | 9.71 | 84 | 205514 | 8639 | 70714207 |
Intervertebral discitis | 42.05 | 9.71 | 56 | 205542 | 4105 | 70718741 |
Pulmonary malformation | 42.03 | 9.71 | 17 | 205581 | 171 | 70722675 |
Carotid artery thrombosis | 41.94 | 9.71 | 44 | 205554 | 2502 | 70720344 |
Lung cyst | 41.46 | 9.71 | 19 | 205579 | 265 | 70722581 |
Red blood cell sedimentation rate abnormal | 41.41 | 9.71 | 4 | 205594 | 19299 | 70703547 |
Neuralgia | 40.93 | 9.71 | 178 | 205420 | 28425 | 70694421 |
C-reactive protein increased | 40.82 | 9.71 | 173 | 205425 | 110344 | 70612502 |
Pneumocystis jirovecii pneumonia | 40.81 | 9.71 | 18 | 205580 | 30064 | 70692782 |
Sleep apnoea syndrome | 40.44 | 9.71 | 195 | 205403 | 32518 | 70690328 |
Bradyphrenia | 40.16 | 9.71 | 89 | 205509 | 9857 | 70712989 |
Self esteem decreased | 40.15 | 9.71 | 28 | 205570 | 905 | 70721941 |
Overdose | 39.98 | 9.71 | 703 | 204895 | 169042 | 70553804 |
Pulmonary fibrosis | 39.95 | 9.71 | 25 | 205573 | 34285 | 70688561 |
Gastrointestinal haemorrhage | 39.91 | 9.71 | 234 | 205364 | 137174 | 70585672 |
Autonomic dysreflexia | 39.79 | 9.71 | 21 | 205577 | 404 | 70722442 |
Infection | 39.15 | 9.71 | 406 | 205192 | 210379 | 70512467 |
Bone density abnormal | 38.87 | 9.71 | 45 | 205553 | 2858 | 70719988 |
Akathisia | 38.83 | 9.71 | 100 | 205498 | 12193 | 70710653 |
Sedation | 38.69 | 9.71 | 250 | 205348 | 46481 | 70676365 |
Rash maculo-papular | 38.64 | 9.71 | 54 | 205544 | 50491 | 70672355 |
Myoclonus | 38.47 | 9.71 | 165 | 205433 | 26190 | 70696656 |
Hypersomnia | 38.39 | 9.71 | 140 | 205458 | 20624 | 70702222 |
Morbid thoughts | 38.05 | 9.71 | 25 | 205573 | 731 | 70722115 |
Abdominal discomfort | 38.04 | 9.71 | 418 | 205180 | 214240 | 70508606 |
Impaired healing | 38.04 | 9.71 | 101 | 205497 | 74273 | 70648573 |
Concussion | 37.63 | 9.71 | 79 | 205519 | 8430 | 70714416 |
Head injury | 37.61 | 9.71 | 197 | 205401 | 33944 | 70688902 |
Rheumatoid arthritis | 37.58 | 9.71 | 607 | 204991 | 291198 | 70431648 |
Aspergillus infection | 37.56 | 9.71 | 4 | 205594 | 17864 | 70704982 |
Neck mass | 37.28 | 9.71 | 53 | 205545 | 4133 | 70718713 |
Irritable bowel syndrome | 37.22 | 9.71 | 56 | 205542 | 50794 | 70672052 |
Rebound nasal congestion | 37.21 | 9.71 | 10 | 205588 | 21 | 70722825 |
Hostility | 37.20 | 9.71 | 39 | 205559 | 2216 | 70720630 |
Rheumatic fever | 37.00 | 9.71 | 4 | 205594 | 17656 | 70705190 |
Rapid eye movements sleep abnormal | 36.79 | 9.71 | 17 | 205581 | 242 | 70722604 |
Anovulatory cycle | 36.37 | 9.71 | 14 | 205584 | 122 | 70722724 |
Cystitis | 36.37 | 9.71 | 247 | 205351 | 46694 | 70676152 |
Cardiogenic shock | 36.37 | 9.71 | 31 | 205567 | 36276 | 70686570 |
Agranulocytosis | 36.15 | 9.71 | 38 | 205560 | 40260 | 70682586 |
Hallucination, auditory | 35.95 | 9.71 | 126 | 205472 | 18202 | 70704644 |
Alanine aminotransferase increased | 35.88 | 9.71 | 614 | 204984 | 146866 | 70575980 |
Haemoptysis | 35.45 | 9.71 | 59 | 205539 | 51393 | 70671453 |
Ankle fracture | 35.00 | 9.71 | 111 | 205487 | 15233 | 70707613 |
Analgesic drug level above therapeutic | 34.94 | 9.71 | 20 | 205578 | 454 | 70722392 |
Libido decreased | 34.90 | 9.71 | 56 | 205542 | 4860 | 70717986 |
Muscle spasms | 34.86 | 9.71 | 634 | 204964 | 153412 | 70569434 |
Hypomagnesaemia | 34.85 | 9.71 | 40 | 205558 | 40724 | 70682122 |
Sleep-related eating disorder | 34.61 | 9.71 | 23 | 205575 | 686 | 70722160 |
Sacroiliitis | 34.54 | 9.71 | 45 | 205553 | 3228 | 70719618 |
Disseminated intravascular coagulation | 34.50 | 9.71 | 28 | 205570 | 33570 | 70689276 |
Gastrooesophageal reflux disease | 34.48 | 9.71 | 409 | 205189 | 90430 | 70632416 |
Skin haemorrhage | 34.44 | 9.71 | 85 | 205513 | 10095 | 70712751 |
Prescribed overdose | 34.30 | 9.71 | 163 | 205435 | 27018 | 70695828 |
Bipolar disorder | 34.07 | 9.71 | 71 | 205527 | 7537 | 70715309 |
Melaena | 34.06 | 9.71 | 70 | 205528 | 56285 | 70666561 |
Hypoaesthesia | 33.84 | 9.71 | 630 | 204968 | 153109 | 70569737 |
Dissociation | 33.45 | 9.71 | 45 | 205553 | 3331 | 70719515 |
Impaired driving ability | 32.68 | 9.71 | 54 | 205544 | 4803 | 70718043 |
Opsoclonus myoclonus | 32.56 | 9.71 | 15 | 205583 | 212 | 70722634 |
Cognitive disorder | 32.42 | 9.71 | 294 | 205304 | 60662 | 70662184 |
Epistaxis | 32.40 | 9.71 | 170 | 205428 | 102457 | 70620389 |
Psychotic disorder due to a general medical condition | 31.98 | 9.71 | 16 | 205582 | 274 | 70722572 |
Bacteraemia | 31.91 | 9.71 | 23 | 205575 | 29286 | 70693560 |
Nervousness | 31.86 | 9.71 | 176 | 205422 | 30944 | 70691902 |
Premature delivery | 31.78 | 9.71 | 11 | 205587 | 21293 | 70701553 |
Dehydration | 31.62 | 9.71 | 463 | 205135 | 225679 | 70497167 |
Palmar-plantar erythrodysaesthesia syndrome | 31.32 | 9.71 | 25 | 205573 | 30222 | 70692624 |
Lactic acidosis | 31.25 | 9.71 | 91 | 205507 | 64933 | 70657913 |
Thunderclap headache | 31.06 | 9.71 | 15 | 205583 | 237 | 70722609 |
Tubulointerstitial nephritis | 31.03 | 9.71 | 30 | 205568 | 33046 | 70689800 |
Cerebral infarction | 30.87 | 9.71 | 48 | 205550 | 42961 | 70679885 |
Gait disturbance | 30.78 | 9.71 | 728 | 204870 | 184378 | 70538468 |
Oesophageal pain | 30.75 | 9.71 | 46 | 205552 | 3756 | 70719090 |
Sensitivity to weather change | 30.74 | 9.71 | 67 | 205531 | 7338 | 70715508 |
Therapeutic product effect decreased | 30.58 | 9.71 | 266 | 205332 | 142752 | 70580094 |
Bronchial haemorrhage | 30.54 | 9.71 | 27 | 205571 | 1240 | 70721606 |
Metabolic surgery | 30.50 | 9.71 | 25 | 205573 | 1034 | 70721812 |
Drug eruption | 30.38 | 9.71 | 42 | 205556 | 39454 | 70683392 |
Metabolic acidosis | 30.23 | 9.71 | 112 | 205486 | 74234 | 70648612 |
Depressive symptom | 30.13 | 9.71 | 54 | 205544 | 5127 | 70717719 |
Rheumatoid nodule | 30.12 | 9.71 | 4 | 205594 | 15063 | 70707783 |
Neoplasm progression | 30.12 | 9.71 | 53 | 205545 | 45175 | 70677671 |
Aspartate aminotransferase increased | 29.93 | 9.71 | 526 | 205072 | 126452 | 70596394 |
Antidepressant drug level above therapeutic | 29.78 | 9.71 | 20 | 205578 | 607 | 70722239 |
Aggression | 29.62 | 9.71 | 241 | 205357 | 48205 | 70674641 |
Prostate cancer | 29.55 | 9.71 | 28 | 205570 | 31135 | 70691711 |
Toxic epidermal necrolysis | 29.50 | 9.71 | 43 | 205555 | 39514 | 70683332 |
Respiratory tract congestion | 29.30 | 9.71 | 115 | 205483 | 17538 | 70705308 |
Emotional disorder | 28.65 | 9.71 | 94 | 205504 | 13132 | 70709714 |
Cytokine release syndrome | 28.52 | 9.71 | 21 | 205577 | 26446 | 70696400 |
Spinal operation | 28.50 | 9.71 | 63 | 205535 | 6965 | 70715881 |
Speech disorder | 28.47 | 9.71 | 247 | 205351 | 50333 | 70672513 |
Haematuria | 28.39 | 9.71 | 92 | 205506 | 63481 | 70659365 |
Psychotic disorder | 28.39 | 9.71 | 197 | 205401 | 37504 | 70685342 |
Respiratory distress | 28.11 | 9.71 | 74 | 205524 | 54576 | 70668270 |
Aplastic anaemia | 27.92 | 9.71 | 7 | 205591 | 16709 | 70706137 |
Sinus congestion | 27.89 | 9.71 | 112 | 205486 | 17261 | 70705585 |
Poor quality sleep | 27.87 | 9.71 | 125 | 205473 | 20224 | 70702622 |
Muscle spasticity | 27.77 | 9.71 | 122 | 205476 | 19567 | 70703279 |
Graft versus host disease | 27.73 | 9.71 | 5 | 205593 | 15018 | 70707828 |
Sinus disorder | 27.14 | 9.71 | 118 | 205480 | 18841 | 70704005 |
Tumour lysis syndrome | 27.11 | 9.71 | 14 | 205584 | 21346 | 70701500 |
Hypotension | 26.85 | 9.71 | 931 | 204667 | 403450 | 70319396 |
Psychomotor hyperactivity | 26.81 | 9.71 | 102 | 205496 | 15331 | 70707515 |
Enterococcal infection | 26.60 | 9.71 | 5 | 205593 | 14577 | 70708269 |
Road traffic accident | 26.57 | 9.71 | 182 | 205416 | 34500 | 70688346 |
Pneumonitis | 26.53 | 9.71 | 76 | 205522 | 54521 | 70668325 |
Formication | 26.39 | 9.71 | 48 | 205550 | 4609 | 70718237 |
Blood lactate dehydrogenase increased | 26.38 | 9.71 | 38 | 205560 | 35089 | 70687757 |
Pseudomonas infection | 26.35 | 9.71 | 11 | 205587 | 18983 | 70703863 |
Apathy | 26.13 | 9.71 | 85 | 205513 | 11823 | 70711023 |
Galactorrhoea | 26.09 | 9.71 | 40 | 205558 | 3338 | 70719508 |
Ill-defined disorder | 26.02 | 9.71 | 77 | 205521 | 54664 | 70668182 |
Psoriasis | 25.85 | 9.71 | 415 | 205183 | 98018 | 70624828 |
Paranoia | 25.82 | 9.71 | 109 | 205489 | 17179 | 70705667 |
Bladder cancer | 25.55 | 9.71 | 9 | 205589 | 17233 | 70705613 |
Respiratory tract malformation | 25.51 | 9.71 | 10 | 205588 | 92 | 70722754 |
Angioedema | 25.38 | 9.71 | 103 | 205495 | 66507 | 70656339 |
Cholestasis | 25.25 | 9.71 | 64 | 205534 | 47808 | 70675038 |
Hypokalaemia | 25.04 | 9.71 | 251 | 205347 | 130937 | 70591909 |
Plasma cell myeloma | 24.97 | 9.71 | 118 | 205480 | 73083 | 70649763 |
Dystonia | 24.74 | 9.71 | 118 | 205480 | 19588 | 70703258 |
Myelodysplastic syndrome | 24.63 | 9.71 | 30 | 205568 | 29755 | 70693091 |
Acute myocardial infarction | 24.56 | 9.71 | 118 | 205480 | 72769 | 70650077 |
Eosinophilia | 24.43 | 9.71 | 50 | 205548 | 40269 | 70682577 |
Haematotoxicity | 24.29 | 9.71 | 5 | 205593 | 13669 | 70709177 |
Phagophobia | 24.23 | 9.71 | 8 | 205590 | 42 | 70722804 |
Demyelination | 24.04 | 9.71 | 60 | 205538 | 7176 | 70715670 |
Lactation disorder | 23.96 | 9.71 | 12 | 205586 | 206 | 70722640 |
Bradycardia | 23.96 | 9.71 | 238 | 205360 | 124377 | 70598469 |
Anorgasmia | 23.94 | 9.71 | 22 | 205576 | 1063 | 70721783 |
Blood calcium decreased | 23.91 | 9.71 | 29 | 205569 | 28817 | 70694029 |
Post-traumatic neck syndrome | 23.80 | 9.71 | 29 | 205569 | 1944 | 70720902 |
Maternal exposure during breast feeding | 23.59 | 9.71 | 31 | 205567 | 2243 | 70720603 |
Hypoalbuminaemia | 23.58 | 9.71 | 13 | 205585 | 19109 | 70703737 |
Electric shock sensation | 23.52 | 9.71 | 17 | 205581 | 582 | 70722264 |
Depression suicidal | 23.45 | 9.71 | 35 | 205563 | 2852 | 70719994 |
Myocardial infarction | 23.44 | 9.71 | 353 | 205245 | 171292 | 70551554 |
Pathogen resistance | 23.29 | 9.71 | 5 | 205593 | 13274 | 70709572 |
Cataplexy | 23.15 | 9.71 | 21 | 205577 | 998 | 70721848 |
Pulseless electrical activity | 23.13 | 9.71 | 5 | 205593 | 13210 | 70709636 |
Toxic skin eruption | 23.05 | 9.71 | 15 | 205583 | 20147 | 70702699 |
Device related infection | 23.02 | 9.71 | 36 | 205562 | 32149 | 70690697 |
Pain in extremity | 22.97 | 9.71 | 1167 | 204431 | 326915 | 70395931 |
Middle insomnia | 22.88 | 9.71 | 91 | 205507 | 13962 | 70708884 |
Product prescribing error | 22.86 | 9.71 | 192 | 205406 | 38760 | 70684086 |
Hyperglycaemia | 22.80 | 9.71 | 103 | 205495 | 64569 | 70658277 |
Delusion | 22.80 | 9.71 | 113 | 205485 | 19052 | 70703794 |
Peripheral swelling | 22.77 | 9.71 | 517 | 205081 | 236046 | 70486800 |
Speech sound disorder | 22.67 | 9.71 | 8 | 205590 | 53 | 70722793 |
Acute respiratory distress syndrome | 22.66 | 9.71 | 54 | 205544 | 41200 | 70681646 |
Metastases to bone | 22.54 | 9.71 | 19 | 205579 | 22357 | 70700489 |
Eating disorder | 22.47 | 9.71 | 110 | 205488 | 18455 | 70704391 |
Feeling jittery | 22.34 | 9.71 | 79 | 205519 | 11464 | 70711382 |
Creatinine renal clearance decreased | 22.24 | 9.71 | 11 | 205587 | 17189 | 70705657 |
Thrombotic microangiopathy | 22.20 | 9.71 | 12 | 205586 | 17836 | 70705010 |
Drug screen positive | 22.18 | 9.71 | 51 | 205547 | 5789 | 70717057 |
Feeling guilty | 22.06 | 9.71 | 19 | 205579 | 842 | 70722004 |
Bruxism | 21.86 | 9.71 | 39 | 205559 | 3690 | 70719156 |
Therapy non-responder | 21.78 | 9.71 | 132 | 205466 | 76783 | 70646063 |
Hypnopompic hallucination | 21.71 | 9.71 | 8 | 205590 | 61 | 70722785 |
Alcoholism | 21.71 | 9.71 | 43 | 205555 | 4402 | 70718444 |
Skin necrosis | 21.70 | 9.71 | 10 | 205588 | 16281 | 70706565 |
Acute pulmonary oedema | 21.67 | 9.71 | 6 | 205592 | 13406 | 70709440 |
Metastases to liver | 21.47 | 9.71 | 26 | 205572 | 25852 | 70696994 |
Gastrointestinal disorder | 21.26 | 9.71 | 199 | 205399 | 105228 | 70617618 |
Poisoning | 21.23 | 9.71 | 125 | 205473 | 22497 | 70700349 |
Tenosynovitis | 21.23 | 9.71 | 7 | 205591 | 13969 | 70708877 |
Somnambulism | 21.16 | 9.71 | 47 | 205551 | 5213 | 70717633 |
Epstein-Barr virus infection | 21.14 | 9.71 | 6 | 205592 | 13192 | 70709654 |
Anaphylactic reaction | 21.06 | 9.71 | 129 | 205469 | 74845 | 70648001 |
Gambling disorder | 21.01 | 9.71 | 27 | 205571 | 1911 | 70720935 |
Lung disorder | 20.88 | 9.71 | 117 | 205481 | 69367 | 70653479 |
Proteinuria | 20.87 | 9.71 | 33 | 205565 | 29341 | 70693505 |
Second primary malignancy | 20.79 | 9.71 | 6 | 205592 | 13045 | 70709801 |
Sexual dysfunction | 20.74 | 9.71 | 54 | 205544 | 6627 | 70716219 |
International normalised ratio increased | 20.60 | 9.71 | 143 | 205455 | 80583 | 70642263 |
Deep vein thrombosis | 20.55 | 9.71 | 214 | 205384 | 110828 | 70612018 |
Ejection fraction decreased | 20.52 | 9.71 | 36 | 205562 | 30726 | 70692120 |
Pulmonary eosinophilia | 20.46 | 9.71 | 16 | 205582 | 618 | 70722228 |
Pustular psoriasis | 20.36 | 9.71 | 43 | 205555 | 4607 | 70718239 |
Hypoventilation | 20.23 | 9.71 | 53 | 205545 | 6529 | 70716317 |
Hypoxia | 20.22 | 9.71 | 173 | 205425 | 93171 | 70629675 |
Product use issue | 20.04 | 9.71 | 384 | 205214 | 179553 | 70543293 |
Muscular weakness | 20.00 | 9.71 | 534 | 205064 | 137802 | 70585044 |
Adjustment disorder | 19.88 | 9.71 | 34 | 205564 | 3110 | 70719736 |
Hypertonia | 19.64 | 9.71 | 52 | 205546 | 6446 | 70716400 |
Diplopia | 19.41 | 9.71 | 144 | 205454 | 28003 | 70694843 |
Phobia of driving | 19.39 | 9.71 | 4 | 205594 | 0 | 70722846 |
Decompression sickness | 19.15 | 9.71 | 7 | 205591 | 52 | 70722794 |
Growth hormone deficiency | 19.09 | 9.71 | 13 | 205585 | 404 | 70722442 |
Live birth | 19.08 | 9.71 | 8 | 205590 | 13771 | 70709075 |
Peritonitis | 18.96 | 9.71 | 29 | 205569 | 26130 | 70696716 |
Hepatitis E antibody positive | 18.93 | 9.71 | 11 | 205587 | 257 | 70722589 |
Pulmonary arterial hypertension | 18.86 | 9.71 | 42 | 205556 | 32813 | 70690033 |
Snoring | 18.81 | 9.71 | 43 | 205555 | 4861 | 70717985 |
Initial insomnia | 18.58 | 9.71 | 50 | 205548 | 6259 | 70716587 |
Tension | 18.55 | 9.71 | 38 | 205560 | 3986 | 70718860 |
Pulmonary oedema | 18.50 | 9.71 | 151 | 205447 | 82127 | 70640719 |
Scar | 18.49 | 9.71 | 85 | 205513 | 13896 | 70708950 |
Hepatic steatosis | 18.45 | 9.71 | 164 | 205434 | 33649 | 70689197 |
Urinary incontinence | 18.36 | 9.71 | 179 | 205419 | 37663 | 70685183 |
Bronchial disorder | 18.36 | 9.71 | 28 | 205570 | 2326 | 70720520 |
Increased appetite | 18.32 | 9.71 | 70 | 205528 | 10543 | 70712303 |
Delirium | 18.26 | 9.71 | 311 | 205287 | 74303 | 70648543 |
Sleep terror | 18.26 | 9.71 | 20 | 205578 | 1195 | 70721651 |
Pre-existing condition improved | 18.25 | 9.71 | 43 | 205555 | 4959 | 70717887 |
Arteriosclerosis coronary artery | 18.16 | 9.71 | 94 | 205504 | 16121 | 70706725 |
Tearfulness | 18.15 | 9.71 | 43 | 205555 | 4977 | 70717869 |
Neuropathy peripheral | 18.11 | 9.71 | 489 | 205109 | 126407 | 70596439 |
Flat affect | 18.09 | 9.71 | 25 | 205573 | 1898 | 70720948 |
Hepatitis E virus test positive | 18.09 | 9.71 | 11 | 205587 | 280 | 70722566 |
Prescribed underdose | 18.06 | 9.71 | 115 | 205483 | 21270 | 70701576 |
Hepatotoxicity | 18.05 | 9.71 | 66 | 205532 | 43920 | 70678926 |
Palpitations | 17.91 | 9.71 | 434 | 205164 | 110319 | 70612527 |
Motor dysfunction | 17.69 | 9.71 | 80 | 205518 | 12990 | 70709856 |
Hepatocellular carcinoma | 17.59 | 9.71 | 4 | 205594 | 10204 | 70712642 |
Feeling drunk | 17.54 | 9.71 | 39 | 205559 | 4328 | 70718518 |
Hyperuricaemia | 17.54 | 9.71 | 5 | 205593 | 10961 | 70711885 |
Cytomegalovirus viraemia | 17.49 | 9.71 | 6 | 205592 | 11679 | 70711167 |
Pneumothorax | 17.47 | 9.71 | 30 | 205568 | 25816 | 70697030 |
Compulsive shopping | 17.43 | 9.71 | 16 | 205582 | 772 | 70722074 |
Haemorrhage | 17.42 | 9.71 | 157 | 205441 | 83658 | 70639188 |
Therapeutic product effect incomplete | 17.40 | 9.71 | 463 | 205135 | 119419 | 70603427 |
Hyponatraemic encephalopathy | 17.39 | 9.71 | 11 | 205587 | 301 | 70722545 |
Exposure via breast milk | 17.36 | 9.71 | 17 | 205581 | 890 | 70721956 |
CYP3A4 polymorphism | 17.34 | 9.71 | 7 | 205591 | 70 | 70722776 |
Haemolytic anaemia | 17.24 | 9.71 | 14 | 205584 | 16780 | 70706066 |
Haemodialysis | 17.18 | 9.71 | 15 | 205583 | 17351 | 70705495 |
Sleep talking | 17.17 | 9.71 | 18 | 205580 | 1023 | 70721823 |
Dyspnoea exertional | 17.15 | 9.71 | 145 | 205453 | 78285 | 70644561 |
Soft tissue injury | 17.13 | 9.71 | 23 | 205575 | 1699 | 70721147 |
Intentional product use issue | 17.12 | 9.71 | 245 | 205353 | 119897 | 70602949 |
Neck pain | 17.11 | 9.71 | 280 | 205318 | 66377 | 70656469 |
Mydriasis | 16.97 | 9.71 | 92 | 205506 | 16061 | 70706785 |
Feelings of worthlessness | 16.95 | 9.71 | 13 | 205585 | 488 | 70722358 |
Therapeutic response changed | 16.77 | 9.71 | 18 | 205580 | 1051 | 70721795 |
Colitis ulcerative | 16.64 | 9.71 | 47 | 205551 | 33876 | 70688970 |
Acute stress disorder | 16.52 | 9.71 | 12 | 205586 | 414 | 70722432 |
Diffuse large B-cell lymphoma | 16.47 | 9.71 | 9 | 205589 | 13293 | 70709553 |
Decreased interest | 16.46 | 9.71 | 33 | 205565 | 3408 | 70719438 |
Shoulder operation | 16.41 | 9.71 | 27 | 205571 | 2393 | 70720453 |
Hyperbilirubinaemia | 16.37 | 9.71 | 25 | 205573 | 22543 | 70700303 |
Granulomatous liver disease | 16.33 | 9.71 | 19 | 205579 | 1213 | 70721633 |
Basal cell carcinoma | 16.30 | 9.71 | 47 | 205551 | 33651 | 70689195 |
Rhonchi | 16.24 | 9.71 | 34 | 205564 | 3621 | 70719225 |
Carcinoid tumour pulmonary | 16.20 | 9.71 | 11 | 205587 | 340 | 70722506 |
Status epilepticus | 16.09 | 9.71 | 29 | 205569 | 24497 | 70698349 |
Homicidal ideation | 16.05 | 9.71 | 32 | 205566 | 3291 | 70719555 |
Visual impairment | 15.99 | 9.71 | 324 | 205274 | 79926 | 70642920 |
Urinary hesitation | 15.96 | 9.71 | 34 | 205564 | 3665 | 70719181 |
Haemophagocytic lymphohistiocytosis | 15.96 | 9.71 | 20 | 205578 | 19592 | 70703254 |
Pulmonary haemorrhage | 15.87 | 9.71 | 10 | 205588 | 13663 | 70709183 |
Feeling hot | 15.84 | 9.71 | 213 | 205385 | 48457 | 70674389 |
Rapid eye movement sleep behaviour disorder | 15.82 | 9.71 | 11 | 205587 | 354 | 70722492 |
Hyponatraemia | 15.77 | 9.71 | 590 | 205008 | 159497 | 70563349 |
Sinus tachycardia | 15.77 | 9.71 | 159 | 205439 | 33754 | 70689092 |
Tuberculosis | 15.72 | 9.71 | 12 | 205586 | 14836 | 70708010 |
Intestinal perforation | 15.70 | 9.71 | 14 | 205584 | 16030 | 70706816 |
Scoliosis | 15.68 | 9.71 | 48 | 205550 | 6463 | 70716383 |
Ischaemic stroke | 15.64 | 9.71 | 42 | 205556 | 30778 | 70692068 |
Urinary tract infection | 15.62 | 9.71 | 876 | 204722 | 247893 | 70474953 |
Renal tubular necrosis | 15.56 | 9.71 | 27 | 205571 | 23144 | 70699702 |
Drug screen false positive | 15.52 | 9.71 | 17 | 205581 | 1016 | 70721830 |
Diarrhoea | 15.49 | 9.71 | 2012 | 203586 | 781329 | 69941517 |
Eye pain | 15.43 | 9.71 | 159 | 205439 | 33943 | 70688903 |
Metastases to lung | 15.41 | 9.71 | 15 | 205583 | 16469 | 70706377 |
Angina unstable | 15.40 | 9.71 | 14 | 205584 | 15879 | 70706967 |
Circulatory collapse | 15.38 | 9.71 | 52 | 205546 | 35422 | 70687424 |
Poverty of speech | 15.29 | 9.71 | 13 | 205585 | 566 | 70722280 |
Convulsive threshold lowered | 15.28 | 9.71 | 16 | 205582 | 908 | 70721938 |
Bone erosion | 15.14 | 9.71 | 13 | 205585 | 15160 | 70707686 |
Spondyloarthropathy | 15.12 | 9.71 | 16 | 205582 | 919 | 70721927 |
Clostridium difficile colitis | 15.11 | 9.71 | 39 | 205559 | 28957 | 70693889 |
Hysterectomy | 15.07 | 9.71 | 43 | 205555 | 5569 | 70717277 |
Immobilisation prolonged | 14.94 | 9.71 | 7 | 205591 | 103 | 70722743 |
Dissociative disorder | 14.86 | 9.71 | 12 | 205586 | 486 | 70722360 |
Intervertebral disc protrusion | 14.82 | 9.71 | 110 | 205488 | 21393 | 70701453 |
Inflammation | 14.80 | 9.71 | 151 | 205447 | 78514 | 70644332 |
Dysphagia | 14.75 | 9.71 | 430 | 205168 | 112404 | 70610442 |
Ophthalmic vein thrombosis | 14.74 | 9.71 | 9 | 205589 | 231 | 70722615 |
Myocardial ischaemia | 14.67 | 9.71 | 30 | 205568 | 24170 | 70698676 |
Open reduction of fracture | 14.67 | 9.71 | 9 | 205589 | 233 | 70722613 |
Burning sensation | 14.67 | 9.71 | 225 | 205373 | 52645 | 70670201 |
Renal injury | 14.63 | 9.71 | 15 | 205583 | 16079 | 70706767 |
Hyperventilation | 14.61 | 9.71 | 50 | 205548 | 7136 | 70715710 |
Acute hepatic failure | 14.59 | 9.71 | 37 | 205561 | 27635 | 70695211 |
Drug abuse | 14.57 | 9.71 | 543 | 205055 | 146713 | 70576133 |
Red blood cell sedimentation rate increased | 14.56 | 9.71 | 60 | 205538 | 38582 | 70684264 |
Klebsiella infection | 14.56 | 9.71 | 12 | 205586 | 14280 | 70708566 |
Rectocele repair | 14.54 | 9.71 | 3 | 205595 | 0 | 70722846 |
Clitoral engorgement | 14.54 | 9.71 | 3 | 205595 | 0 | 70722846 |
Lymphoma | 14.53 | 9.71 | 14 | 205584 | 15448 | 70707398 |
Anaphylactic shock | 14.52 | 9.71 | 47 | 205551 | 32443 | 70690403 |
Shock | 14.48 | 9.71 | 64 | 205534 | 40361 | 70682485 |
Illness anxiety disorder | 14.47 | 9.71 | 9 | 205589 | 239 | 70722607 |
Lacunar stroke | 14.45 | 9.71 | 10 | 205588 | 319 | 70722527 |
Pericardial effusion | 14.45 | 9.71 | 67 | 205531 | 41709 | 70681137 |
Hypoglycaemia | 14.31 | 9.71 | 190 | 205408 | 94174 | 70628672 |
Atelectasis | 14.30 | 9.71 | 40 | 205558 | 28922 | 70693924 |
Suspected suicide | 14.22 | 9.71 | 57 | 205541 | 8777 | 70714069 |
Joint noise | 14.19 | 9.71 | 31 | 205567 | 3400 | 70719446 |
Oedema | 14.14 | 9.71 | 213 | 205385 | 103368 | 70619478 |
Haemolysis | 14.03 | 9.71 | 8 | 205590 | 11543 | 70711303 |
Respiratory arrest | 14.01 | 9.71 | 227 | 205371 | 53706 | 70669140 |
Blood urea increased | 13.96 | 9.71 | 77 | 205521 | 45832 | 70677014 |
Atrioventricular block complete | 13.94 | 9.71 | 14 | 205584 | 15149 | 70707697 |
Nephropathy toxic | 13.93 | 9.71 | 20 | 205578 | 18494 | 70704352 |
Drug metabolising enzyme decreased | 13.88 | 9.71 | 4 | 205594 | 12 | 70722834 |
Hypercalcaemia | 13.84 | 9.71 | 52 | 205546 | 34333 | 70688513 |
Obsessive-compulsive personality disorder | 13.83 | 9.71 | 7 | 205591 | 123 | 70722723 |
Oesophagitis | 13.80 | 9.71 | 28 | 205570 | 22624 | 70700222 |
Hospitalisation | 13.79 | 9.71 | 325 | 205273 | 82243 | 70640603 |
Polyarthritis | 13.72 | 9.71 | 7 | 205591 | 10749 | 70712097 |
Oliguria | 13.72 | 9.71 | 14 | 205584 | 15037 | 70707809 |
Radiation fibrosis | 13.70 | 9.71 | 5 | 205593 | 37 | 70722809 |
Aphasia | 13.56 | 9.71 | 188 | 205410 | 43061 | 70679785 |
Hypervolaemia | 13.54 | 9.71 | 64 | 205534 | 39642 | 70683204 |
Anal incontinence | 13.51 | 9.71 | 88 | 205510 | 16402 | 70706444 |
Undifferentiated connective tissue disease | 13.47 | 9.71 | 5 | 205593 | 39 | 70722807 |
Nephrotic syndrome | 13.46 | 9.71 | 7 | 205591 | 10633 | 70712213 |
Parosmia | 13.45 | 9.71 | 38 | 205560 | 4893 | 70717953 |
Pneumonia fungal | 13.43 | 9.71 | 6 | 205592 | 9947 | 70712899 |
Rib fracture | 13.33 | 9.71 | 122 | 205476 | 25234 | 70697612 |
Illusion | 13.32 | 9.71 | 20 | 205578 | 1639 | 70721207 |
Mean cell haemoglobin concentration increased | 13.23 | 9.71 | 14 | 205584 | 804 | 70722042 |
Pyometra | 13.20 | 9.71 | 6 | 205592 | 82 | 70722764 |
Gastric haemorrhage | 13.15 | 9.71 | 13 | 205585 | 14172 | 70708674 |
Panic disorder | 13.15 | 9.71 | 27 | 205571 | 2837 | 70720009 |
Movement disorder | 13.15 | 9.71 | 117 | 205481 | 24012 | 70698834 |
Impulse-control disorder | 13.13 | 9.71 | 20 | 205578 | 1659 | 70721187 |
Skin lesion | 13.11 | 9.71 | 62 | 205536 | 38398 | 70684448 |
Sternal fracture | 13.03 | 9.71 | 24 | 205574 | 2327 | 70720519 |
Tongue movement disturbance | 13.00 | 9.71 | 10 | 205588 | 377 | 70722469 |
Heart rate decreased | 12.96 | 9.71 | 116 | 205482 | 61899 | 70660947 |
Gambling | 12.96 | 9.71 | 9 | 205589 | 289 | 70722557 |
Coagulopathy | 12.92 | 9.71 | 51 | 205547 | 33198 | 70689648 |
Economic problem | 12.85 | 9.71 | 23 | 205575 | 2181 | 70720665 |
Chronic kidney disease | 12.85 | 9.71 | 114 | 205484 | 60943 | 70661903 |
Social avoidant behaviour | 12.82 | 9.71 | 36 | 205562 | 4620 | 70718226 |
Musculoskeletal discomfort | 12.74 | 9.71 | 92 | 205506 | 17740 | 70705106 |
Panic reaction | 12.73 | 9.71 | 34 | 205564 | 4237 | 70718609 |
Trismus | 12.70 | 9.71 | 38 | 205560 | 5053 | 70717793 |
Sciatic nerve injury | 12.67 | 9.71 | 11 | 205587 | 493 | 70722353 |
Dysstasia | 12.66 | 9.71 | 120 | 205478 | 25059 | 70697787 |
Sensory loss | 12.65 | 9.71 | 66 | 205532 | 11353 | 70711493 |
Metastases to central nervous system | 12.58 | 9.71 | 15 | 205583 | 15019 | 70707827 |
Posterior reversible encephalopathy syndrome | 12.58 | 9.71 | 33 | 205565 | 24369 | 70698477 |
Accidental death | 12.56 | 9.71 | 32 | 205566 | 3876 | 70718970 |
Haemoglobin urine present | 12.56 | 9.71 | 14 | 205584 | 853 | 70721993 |
Adiposis dolorosa | 12.56 | 9.71 | 9 | 205589 | 304 | 70722542 |
Red blood cell count decreased | 12.53 | 9.71 | 94 | 205504 | 52067 | 70670779 |
Liver disorder | 12.50 | 9.71 | 116 | 205482 | 61452 | 70661394 |
Bone density decreased | 12.50 | 9.71 | 9 | 205589 | 11465 | 70711381 |
Bipolar I disorder | 12.48 | 9.71 | 21 | 205577 | 1896 | 70720950 |
Floating patella | 12.47 | 9.71 | 3 | 205595 | 3 | 70722843 |
Psychopathic personality | 12.47 | 9.71 | 3 | 205595 | 3 | 70722843 |
Loose tooth | 12.45 | 9.71 | 27 | 205571 | 2947 | 70719899 |
Multiple-drug resistance | 12.44 | 9.71 | 3 | 205595 | 7352 | 70715494 |
Rales | 12.41 | 9.71 | 19 | 205579 | 17116 | 70705730 |
Pulmonary toxicity | 12.39 | 9.71 | 8 | 205590 | 10790 | 70712056 |
Right ventricular failure | 12.36 | 9.71 | 29 | 205569 | 22245 | 70700601 |
Asphyxia | 12.32 | 9.71 | 61 | 205537 | 10281 | 70712565 |
Respiratory depression | 12.31 | 9.71 | 118 | 205480 | 24713 | 70698133 |
Febrile bone marrow aplasia | 12.30 | 9.71 | 10 | 205588 | 11981 | 70710865 |
Application site perspiration | 12.28 | 9.71 | 4 | 205594 | 20 | 70722826 |
Intervertebral disc operation | 12.27 | 9.71 | 14 | 205584 | 875 | 70721971 |
Hip arthroplasty | 12.23 | 9.71 | 41 | 205557 | 27999 | 70694847 |
Gastric ulcer | 12.21 | 9.71 | 49 | 205549 | 31741 | 70691105 |
Tachyphrenia | 12.21 | 9.71 | 21 | 205577 | 1930 | 70720916 |
Complex regional pain syndrome | 12.09 | 9.71 | 20 | 205578 | 1780 | 70721066 |
Retrograde ejaculation | 12.08 | 9.71 | 8 | 205590 | 237 | 70722609 |
Lymphoedema | 11.99 | 9.71 | 64 | 205534 | 11105 | 70711741 |
Escherichia infection | 11.94 | 9.71 | 18 | 205580 | 16313 | 70706533 |
Embolism | 11.93 | 9.71 | 12 | 205586 | 12976 | 70709870 |
Supraventricular tachyarrhythmia | 11.93 | 9.71 | 6 | 205592 | 104 | 70722742 |
Acute graft versus host disease in skin | 11.90 | 9.71 | 3 | 205595 | 7134 | 70715712 |
Dysphemia | 11.85 | 9.71 | 28 | 205570 | 3235 | 70719611 |
Metastases to lymph nodes | 11.80 | 9.71 | 6 | 205592 | 9232 | 70713614 |
Post concussion syndrome | 11.74 | 9.71 | 11 | 205587 | 545 | 70722301 |
Transfusion | 11.72 | 9.71 | 23 | 205575 | 18813 | 70704033 |
Ocular vascular disorder | 11.71 | 9.71 | 10 | 205588 | 438 | 70722408 |
Abulia | 11.70 | 9.71 | 14 | 205584 | 921 | 70721925 |
Exposure via ingestion | 11.62 | 9.71 | 36 | 205562 | 4879 | 70717967 |
Forced expiratory volume decreased | 11.62 | 9.71 | 47 | 205551 | 7267 | 70715579 |
Ligament injury | 11.60 | 9.71 | 15 | 205583 | 1068 | 70721778 |
Pulmonary hypertension | 11.59 | 9.71 | 83 | 205515 | 46453 | 70676393 |
Dysarthria | 11.57 | 9.71 | 249 | 205349 | 62064 | 70660782 |
Lip dry | 11.57 | 9.71 | 7 | 205591 | 9778 | 70713068 |
Skin plaque | 11.57 | 9.71 | 7 | 205591 | 9776 | 70713070 |
Impulsive behaviour | 11.52 | 9.71 | 25 | 205573 | 2729 | 70720117 |
Trigger finger | 11.45 | 9.71 | 30 | 205568 | 3697 | 70719149 |
Infective pulmonary exacerbation of cystic fibrosis | 11.44 | 9.71 | 11 | 205587 | 12147 | 70710699 |
Progressive multifocal leukoencephalopathy | 11.43 | 9.71 | 95 | 205503 | 19119 | 70703727 |
Cushingoid | 11.41 | 9.71 | 5 | 205593 | 8383 | 70714463 |
Colitis | 11.39 | 9.71 | 124 | 205474 | 63690 | 70659156 |
Purple glove syndrome | 11.38 | 9.71 | 8 | 205590 | 262 | 70722584 |
Facial spasm | 11.37 | 9.71 | 12 | 205586 | 687 | 70722159 |
Somatic delusion | 11.36 | 9.71 | 12 | 205586 | 688 | 70722158 |
Intentional dose omission | 11.35 | 9.71 | 45 | 205553 | 6896 | 70715950 |
Lung infiltration | 11.33 | 9.71 | 29 | 205569 | 21595 | 70701251 |
Rectal haemorrhage | 11.32 | 9.71 | 129 | 205469 | 65702 | 70657144 |
Forced expiratory flow decreased | 11.30 | 9.71 | 8 | 205590 | 265 | 70722581 |
Holmes-Adie pupil | 11.27 | 9.71 | 4 | 205594 | 27 | 70722819 |
Blood bilirubin increased | 11.26 | 9.71 | 115 | 205483 | 59786 | 70663060 |
Regurgitation | 11.23 | 9.71 | 22 | 205576 | 2234 | 70720612 |
Vasculitis | 11.23 | 9.71 | 25 | 205573 | 19533 | 70703313 |
Large intestine perforation | 11.22 | 9.71 | 13 | 205585 | 13182 | 70709664 |
Drug level decreased | 11.22 | 9.71 | 12 | 205586 | 12612 | 70710234 |
Axillary pain | 11.19 | 9.71 | 20 | 205578 | 1895 | 70720951 |
Cardiac failure acute | 11.19 | 9.71 | 21 | 205577 | 17466 | 70705380 |
Withdrawal hypertension | 11.15 | 9.71 | 9 | 205589 | 364 | 70722482 |
Serum serotonin increased | 11.12 | 9.71 | 8 | 205590 | 272 | 70722574 |
Rhabdomyolysis | 11.07 | 9.71 | 203 | 205395 | 95557 | 70627289 |
Blood pressure diastolic decreased | 11.03 | 9.71 | 38 | 205560 | 25742 | 70697104 |
Blood bilirubin | 11.03 | 9.71 | 4 | 205594 | 29 | 70722817 |
Ventricular hypokinesia | 11.00 | 9.71 | 5 | 205593 | 8207 | 70714639 |
Tethered cord syndrome | 10.95 | 9.71 | 3 | 205595 | 7 | 70722839 |
Acute respiratory failure | 10.94 | 9.71 | 101 | 205497 | 53564 | 70669282 |
Pregnancy | 10.91 | 9.71 | 34 | 205564 | 23747 | 70699099 |
Eye allergy | 10.89 | 9.71 | 11 | 205587 | 598 | 70722248 |
Genital pain | 10.87 | 9.71 | 10 | 205588 | 484 | 70722362 |
Poor sucking reflex | 10.83 | 9.71 | 5 | 205593 | 71 | 70722775 |
Device expulsion | 10.78 | 9.71 | 31 | 205567 | 22215 | 70700631 |
Alveolar bone resorption | 10.77 | 9.71 | 5 | 205593 | 72 | 70722774 |
Cholecystectomy | 10.75 | 9.71 | 51 | 205547 | 8446 | 70714400 |
Cerebral haemorrhage | 10.72 | 9.71 | 102 | 205496 | 53762 | 70669084 |
Paralogism | 10.69 | 9.71 | 4 | 205594 | 32 | 70722814 |
Loss of control of legs | 10.67 | 9.71 | 19 | 205579 | 1795 | 70721051 |
Joint stiffness | 10.66 | 9.71 | 152 | 205446 | 35024 | 70687822 |
Arthroscopy | 10.58 | 9.71 | 10 | 205588 | 501 | 70722345 |
Torsade de pointes | 10.53 | 9.71 | 23 | 205575 | 18093 | 70704753 |
Hyperthyroidism | 10.49 | 9.71 | 27 | 205571 | 20064 | 70702782 |
Leukoencephalopathy | 10.48 | 9.71 | 4 | 205594 | 7290 | 70715556 |
Cachexia | 10.48 | 9.71 | 8 | 205590 | 9892 | 70712954 |
Throat irritation | 10.48 | 9.71 | 152 | 205446 | 35152 | 70687694 |
Delusion of grandeur | 10.41 | 9.71 | 13 | 205585 | 894 | 70721952 |
Cycloplegia | 10.41 | 9.71 | 3 | 205595 | 9 | 70722837 |
Blood prolactin increased | 10.31 | 9.71 | 29 | 205569 | 3725 | 70719121 |
Atrioventricular block | 10.26 | 9.71 | 13 | 205585 | 12675 | 70710171 |
Therapeutic response unexpected | 10.24 | 9.71 | 89 | 205509 | 18142 | 70704704 |
Cholangitis | 10.24 | 9.71 | 11 | 205587 | 11538 | 70711308 |
Hypogammaglobulinaemia | 10.21 | 9.71 | 11 | 205587 | 11527 | 70711319 |
Lupus-like syndrome | 10.17 | 9.71 | 11 | 205587 | 11504 | 70711342 |
Knee operation | 10.16 | 9.71 | 35 | 205563 | 5012 | 70717834 |
Liver function test increased | 10.16 | 9.71 | 57 | 205541 | 33790 | 70689056 |
Persistent genital arousal disorder | 10.14 | 9.71 | 8 | 205590 | 313 | 70722533 |
Communication disorder | 10.12 | 9.71 | 29 | 205569 | 3765 | 70719081 |
Nephrolithiasis | 10.08 | 9.71 | 193 | 205405 | 47130 | 70675716 |
Cephalo-pelvic disproportion | 10.07 | 9.71 | 6 | 205592 | 147 | 70722699 |
Haematochezia | 10.07 | 9.71 | 150 | 205448 | 72931 | 70649915 |
Allodynia | 10.07 | 9.71 | 16 | 205582 | 1377 | 70721469 |
Bacterial infection | 10.07 | 9.71 | 41 | 205557 | 26451 | 70696395 |
Hepatic cancer | 10.03 | 9.71 | 8 | 205590 | 9675 | 70713171 |
Physical assault | 10.00 | 9.71 | 17 | 205581 | 1547 | 70721299 |
Blood pressure systolic decreased | 10.00 | 9.71 | 8 | 205590 | 9663 | 70713183 |
Muscle rigidity | 9.94 | 9.71 | 90 | 205508 | 18560 | 70704286 |
Tachyphylaxis | 9.93 | 9.71 | 8 | 205590 | 323 | 70722523 |
Hepatic encephalopathy | 9.88 | 9.71 | 32 | 205566 | 22086 | 70700760 |
Tachypnoea | 9.86 | 9.71 | 46 | 205552 | 28592 | 70694254 |
Hepatic cytolysis | 9.86 | 9.71 | 26 | 205572 | 19166 | 70703680 |
Labelled drug-food interaction issue | 9.82 | 9.71 | 4 | 205594 | 41 | 70722805 |
Dermatitis acneiform | 9.76 | 9.71 | 7 | 205591 | 8938 | 70713908 |
Activated partial thromboplastin time prolonged | 9.76 | 9.71 | 15 | 205583 | 13490 | 70709356 |
Ceruloplasmin increased | 9.75 | 9.71 | 3 | 205595 | 12 | 70722834 |
Thyroid adenoma | 9.72 | 9.71 | 6 | 205592 | 157 | 70722689 |
Deformity | 9.72 | 9.71 | 6 | 205592 | 8291 | 70714555 |
Shock haemorrhagic | 9.71 | 9.71 | 24 | 205574 | 18082 | 70704764 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Telangiectasia congenital | 30.47 | 28.20 | 9 | 373 | 18 | 89392 |
Liver disorder | 29.80 | 28.20 | 8 | 374 | 9 | 89401 |
Source | Code | Description |
---|---|---|
ATC | N06AX21 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D000068760 | Serotonin and Noradrenaline Reuptake Inhibitors |
FDA EPC | N0000175749 | Serotonin and Norepinephrine Reuptake Inhibitor |
CHEBI has role | CHEBI:35469 | antidepressants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Female stress incontinence | indication | 60241006 | DOID:724 |
Fibromyalgia | indication | 203082005 | DOID:631 |
Major depressive disorder | indication | 370143000 | |
Diabetic peripheral neuropathy | indication | 424736006 | |
Chronic Musculoskeletal Pain | indication | ||
Osteoarthritis | off-label use | 396275006 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Jaundice | contraindication | 18165001 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Orthostatic hypotension | contraindication | 28651003 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Alcoholic liver damage | contraindication | 41309000 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Chronic hepatitis | contraindication | 76783007 | DOID:2237 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Inflammatory disease of liver | contraindication | 128241005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Serotonin syndrome | contraindication | 371089000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastrointestinal hypomotility | contraindication | 421807004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.7 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 20MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
EQ 30MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
EQ 60MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 9.62 | CHEMBL | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 8.22 | CHEMBL | CHEMBL | |||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.30 | PDSP | |||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 6.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.68 | PDSP | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6 | IUPHAR | ||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 6.40 | IUPHAR | ||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.65 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 5.64 | PDSP | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.40 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.52 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.62 | CHEMBL | |||||
5-hydroxytryptamine receptor 1F | GPCR | Ki | 5.35 | PDSP | |||||
5-hydroxytryptamine receptor 1E | GPCR | Ki | 5.43 | PDSP | |||||
Serine hydroxymethyltransferase, mitochondrial | Enzyme | IC50 | 5.16 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 10.09 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 6.43 | CHEMBL | |||||
Transporter | Transporter | Ki | 8.52 | CHEMBL |
ID | Source |
---|---|
D01179 | KEGG_DRUG |
136434-34-9 | SECONDARY_CAS_RN |
4021477 | VANDF |
C0245561 | UMLSCUI |
CHEBI:31526 | CHEBI |
29E | PDB_CHEM_ID |
CHEMBL1175 | ChEMBL_ID |
CHEMBL1200328 | ChEMBL_ID |
DB00476 | DRUGBANK_ID |
D000068736 | MESH_DESCRIPTOR_UI |
60835 | PUBCHEM_CID |
202 | IUPHAR_LIGAND_ID |
7012 | INN_ID |
O5TNM5N07U | UNII |
476250 | RXNORM |
18760 | MMSL |
208014 | MMSL |
33554 | MMSL |
59319 | MMSL |
d05355 | MMSL |
008705 | NDDF |
008707 | NDDF |
407032004 | SNOMEDCT_US |
407033009 | SNOMEDCT_US |
426892003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3235 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3240 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3270 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | NDA | 36 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2890 | CAPSULE, DELAYED RELEASE PELLETS | 20 mg | ORAL | ANDA | 29 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2891 | CAPSULE, DELAYED RELEASE PELLETS | 30 mg | ORAL | ANDA | 29 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2892 | CAPSULE, DELAYED RELEASE PELLETS | 60 mg | ORAL | ANDA | 29 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8203 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8203 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8204 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8204 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8290 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8290 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6452 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6453 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6454 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7043 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7043 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7044 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7044 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7045 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7045 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-111 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-111 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-111 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |