Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 972 | 116539-59-4 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.88 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
CL (Clearance) | 8.57 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 3, 2004 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 4011.27 | 9.73 | 1997 | 208443 | 23084 | 50371600 |
Dysphoria | 3455.79 | 9.73 | 1129 | 209311 | 3645 | 50391039 |
Affect lability | 2815.82 | 9.73 | 1146 | 209294 | 7852 | 50386832 |
Irritability | 2227.33 | 9.73 | 1418 | 209022 | 27008 | 50367676 |
Suicidal ideation | 1887.66 | 9.73 | 1677 | 208763 | 53708 | 50340976 |
Agitation | 1692.30 | 9.73 | 1552 | 208888 | 51832 | 50342852 |
Paraesthesia | 1342.51 | 9.73 | 2046 | 208394 | 118197 | 50276487 |
Sensory disturbance | 1308.29 | 9.73 | 737 | 209703 | 11092 | 50383592 |
Hyperhidrosis | 1246.07 | 9.73 | 1691 | 208749 | 87735 | 50306949 |
Vertigo | 1204.24 | 9.73 | 1272 | 209168 | 50560 | 50344124 |
Insomnia | 1135.32 | 9.73 | 2346 | 208094 | 172519 | 50222165 |
Anxiety | 1024.11 | 9.73 | 2271 | 208169 | 175335 | 50219349 |
Nightmare | 808.13 | 9.73 | 611 | 209829 | 15475 | 50379209 |
Dizziness | 743.39 | 9.73 | 3126 | 207314 | 343243 | 50051441 |
Mood swings | 729.36 | 9.73 | 573 | 209867 | 15381 | 50379303 |
Tinnitus | 615.27 | 9.73 | 669 | 209771 | 27463 | 50367221 |
Hypomania | 548.18 | 9.73 | 299 | 210141 | 4206 | 50390478 |
Tremor | 528.65 | 9.73 | 1347 | 209093 | 113556 | 50281128 |
Lethargy | 526.53 | 9.73 | 824 | 209616 | 48608 | 50346076 |
Serotonin syndrome | 502.94 | 9.73 | 566 | 209874 | 24147 | 50370537 |
Pemphigus | 481.95 | 9.73 | 3 | 210437 | 120163 | 50274521 |
Confusional state | 461.56 | 9.73 | 1758 | 208682 | 184170 | 50210514 |
Glossodynia | 331.85 | 9.73 | 44 | 210396 | 115525 | 50279159 |
Headache | 321.53 | 9.73 | 3365 | 207075 | 503170 | 49891514 |
Withdrawal syndrome | 308.02 | 9.73 | 373 | 210067 | 17217 | 50377467 |
Hand deformity | 292.86 | 9.73 | 36 | 210404 | 100163 | 50294521 |
Alopecia | 286.52 | 9.73 | 359 | 210081 | 244688 | 50149996 |
Systemic lupus erythematosus | 284.91 | 9.73 | 114 | 210326 | 140508 | 50254176 |
Suicide attempt | 275.50 | 9.73 | 642 | 209798 | 51090 | 50343594 |
Maternal exposure during pregnancy | 270.18 | 9.73 | 165 | 210275 | 159613 | 50235071 |
Nausea | 262.18 | 9.73 | 4247 | 206193 | 701151 | 49693533 |
Contraindicated product administered | 255.82 | 9.73 | 151 | 210289 | 148807 | 50245877 |
Synovitis | 237.21 | 9.73 | 109 | 210331 | 123756 | 50270928 |
Pericarditis | 230.60 | 9.73 | 28 | 210412 | 78661 | 50316023 |
Neutropenia | 229.69 | 9.73 | 168 | 210272 | 147797 | 50246887 |
Febrile neutropenia | 216.89 | 9.73 | 68 | 210372 | 97599 | 50297085 |
Wound | 212.23 | 9.73 | 87 | 210353 | 105707 | 50288977 |
Drug intolerance | 210.21 | 9.73 | 368 | 210072 | 218736 | 50175948 |
Depression | 209.85 | 9.73 | 1290 | 209150 | 164133 | 50230551 |
Crying | 205.78 | 9.73 | 332 | 210108 | 20084 | 50374600 |
Sleep disorder | 204.96 | 9.73 | 613 | 209827 | 56670 | 50338014 |
Pyrexia | 203.57 | 9.73 | 852 | 209588 | 379351 | 50015333 |
Disturbance in attention | 199.93 | 9.73 | 417 | 210023 | 30769 | 50363915 |
Anaemia | 194.96 | 9.73 | 480 | 209960 | 251976 | 50142708 |
Completed suicide | 189.52 | 9.73 | 1063 | 209377 | 130826 | 50263858 |
Treatment failure | 186.83 | 9.73 | 178 | 210262 | 137459 | 50257225 |
Abdominal discomfort | 184.72 | 9.73 | 433 | 210007 | 231208 | 50163476 |
Infusion related reaction | 184.19 | 9.73 | 262 | 210178 | 169295 | 50225389 |
Feeling abnormal | 181.33 | 9.73 | 1013 | 209427 | 124479 | 50270205 |
Arthropathy | 180.59 | 9.73 | 235 | 210205 | 157671 | 50237013 |
Stubbornness | 176.66 | 9.73 | 60 | 210380 | 225 | 50394459 |
Rash | 171.64 | 9.73 | 1091 | 209349 | 436380 | 49958304 |
Duodenal ulcer perforation | 170.32 | 9.73 | 4 | 210436 | 45607 | 50349077 |
Discomfort | 163.09 | 9.73 | 127 | 210313 | 108253 | 50286431 |
Thrombocytopenia | 162.01 | 9.73 | 175 | 210265 | 127498 | 50267186 |
Joint swelling | 159.22 | 9.73 | 507 | 209933 | 244779 | 50149905 |
Hypersensitivity | 155.38 | 9.73 | 423 | 210017 | 214738 | 50179946 |
Anti-cyclic citrullinated peptide antibody positive | 151.67 | 9.73 | 52 | 210388 | 70535 | 50324149 |
Mood altered | 151.56 | 9.73 | 224 | 210216 | 12549 | 50382135 |
Swelling | 143.46 | 9.73 | 397 | 210043 | 200475 | 50194209 |
Pancytopenia | 143.03 | 9.73 | 86 | 210354 | 83944 | 50310740 |
Memory impairment | 136.17 | 9.73 | 672 | 209768 | 78688 | 50315996 |
Somnolence | 133.58 | 9.73 | 1101 | 209339 | 153884 | 50240800 |
Acute kidney injury | 132.02 | 9.73 | 495 | 209945 | 227563 | 50167121 |
Thinking abnormal | 127.03 | 9.73 | 177 | 210263 | 9390 | 50385294 |
Fibromyalgia | 126.17 | 9.73 | 443 | 209997 | 44535 | 50350149 |
Anger | 123.46 | 9.73 | 191 | 210249 | 11142 | 50383542 |
Electric shock | 121.66 | 9.73 | 67 | 210373 | 961 | 50393723 |
Lower respiratory tract infection | 120.18 | 9.73 | 131 | 210309 | 95070 | 50299614 |
Migraine | 119.71 | 9.73 | 624 | 209816 | 74656 | 50320028 |
Panic attack | 117.43 | 9.73 | 253 | 210187 | 19089 | 50375595 |
Folliculitis | 117.29 | 9.73 | 13 | 210427 | 39212 | 50355472 |
Fatigue | 113.24 | 9.73 | 3789 | 206651 | 703812 | 49690872 |
Sleep disorder due to general medical condition, insomnia type | 112.86 | 9.73 | 4 | 210436 | 31443 | 50363241 |
Off label use | 111.25 | 9.73 | 1351 | 209089 | 473075 | 49921609 |
General physical health deterioration | 111.23 | 9.73 | 269 | 210171 | 142165 | 50252519 |
Dyspnoea | 109.37 | 9.73 | 1612 | 208828 | 545996 | 49848688 |
Malignant neoplasm progression | 108.72 | 9.73 | 75 | 210365 | 68049 | 50326635 |
Depressed mood | 105.89 | 9.73 | 347 | 210093 | 33676 | 50361008 |
Therapeutic product effect decreased | 103.06 | 9.73 | 261 | 210179 | 135789 | 50258895 |
Drug ineffective | 100.64 | 9.73 | 2619 | 207821 | 816714 | 49577970 |
Platelet count decreased | 100.31 | 9.73 | 165 | 210275 | 100561 | 50294123 |
Disease progression | 98.32 | 9.73 | 154 | 210286 | 95712 | 50298972 |
Muscle injury | 97.69 | 9.73 | 18 | 210422 | 37093 | 50357591 |
C-reactive protein abnormal | 94.97 | 9.73 | 5 | 210435 | 27804 | 50366880 |
Infection | 94.52 | 9.73 | 384 | 210056 | 172570 | 50222114 |
Blister | 90.69 | 9.73 | 134 | 210306 | 85284 | 50309400 |
Septic shock | 89.84 | 9.73 | 64 | 210376 | 57111 | 50337573 |
Rheumatoid factor positive | 89.17 | 9.73 | 48 | 210392 | 49811 | 50344873 |
Gastrointestinal tube insertion | 88.17 | 9.73 | 54 | 210386 | 955 | 50393729 |
Pneumonia | 86.90 | 9.73 | 1082 | 209358 | 377319 | 50017365 |
Product use issue | 86.05 | 9.73 | 325 | 210115 | 149150 | 50245534 |
Affective disorder | 86.05 | 9.73 | 107 | 210333 | 5074 | 50389610 |
Cardiac failure | 84.99 | 9.73 | 115 | 210325 | 75925 | 50318759 |
Coordination abnormal | 84.39 | 9.73 | 163 | 210277 | 11371 | 50383313 |
Gastric bypass | 83.97 | 9.73 | 60 | 210380 | 1388 | 50393296 |
Intentional product misuse | 83.18 | 9.73 | 400 | 210040 | 46334 | 50348350 |
Stomatitis | 82.62 | 9.73 | 187 | 210253 | 101157 | 50293527 |
Helicobacter infection | 81.61 | 9.73 | 53 | 210387 | 49649 | 50345035 |
Inappropriate antidiuretic hormone secretion | 77.60 | 9.73 | 170 | 210270 | 12973 | 50381711 |
Restless legs syndrome | 76.74 | 9.73 | 190 | 210250 | 15707 | 50378977 |
Drug reaction with eosinophilia and systemic symptoms | 76.53 | 9.73 | 13 | 210427 | 28411 | 50366273 |
Abnormal behaviour | 75.67 | 9.73 | 216 | 210224 | 19442 | 50375242 |
Impaired healing | 75.53 | 9.73 | 108 | 210332 | 69678 | 50325006 |
Sepsis | 75.22 | 9.73 | 291 | 210149 | 132634 | 50262050 |
Peripheral swelling | 74.75 | 9.73 | 525 | 209915 | 205411 | 50189273 |
Fall | 72.81 | 9.73 | 1865 | 208575 | 333067 | 50061617 |
Aggression | 72.69 | 9.73 | 223 | 210217 | 20893 | 50373791 |
Pneumonia aspiration | 72.45 | 9.73 | 288 | 210152 | 30716 | 50363968 |
Tardive dyskinesia | 71.48 | 9.73 | 117 | 210323 | 7162 | 50387522 |
Erythema | 70.93 | 9.73 | 340 | 210100 | 146074 | 50248610 |
Neutrophil count decreased | 70.39 | 9.73 | 53 | 210387 | 45973 | 50348711 |
Post-traumatic stress disorder | 70.08 | 9.73 | 88 | 210352 | 4215 | 50390469 |
Mucosal inflammation | 69.82 | 9.73 | 40 | 210400 | 40102 | 50354582 |
Hallucination | 68.87 | 9.73 | 379 | 210061 | 46278 | 50348406 |
Blood creatinine increased | 68.39 | 9.73 | 133 | 210307 | 76027 | 50318657 |
White blood cell count abnormal | 68.31 | 9.73 | 98 | 210342 | 5342 | 50389342 |
Product substitution issue | 67.84 | 9.73 | 168 | 210272 | 13889 | 50380795 |
Renal impairment | 67.19 | 9.73 | 133 | 210307 | 75528 | 50319156 |
Abnormal dreams | 66.76 | 9.73 | 131 | 210309 | 9246 | 50385438 |
Haemoglobin decreased | 66.04 | 9.73 | 288 | 210152 | 126928 | 50267756 |
Somatic symptom disorder | 64.38 | 9.73 | 58 | 210382 | 1886 | 50392798 |
Coma | 64.23 | 9.73 | 431 | 210009 | 56448 | 50338236 |
Amnesia | 64.20 | 9.73 | 346 | 210094 | 41914 | 50352770 |
Multiple sclerosis | 63.75 | 9.73 | 209 | 210231 | 20284 | 50374400 |
Ascites | 63.43 | 9.73 | 35 | 210405 | 35826 | 50358858 |
Leukopenia | 63.21 | 9.73 | 115 | 210325 | 67413 | 50327271 |
Multiple sclerosis relapse | 62.74 | 9.73 | 348 | 210092 | 42616 | 50352068 |
Pleural effusion | 62.63 | 9.73 | 155 | 210285 | 81299 | 50313385 |
Premature delivery | 61.17 | 9.73 | 12 | 210428 | 23651 | 50371033 |
Loss of consciousness | 60.88 | 9.73 | 683 | 209757 | 103670 | 50291014 |
Drug interaction | 59.87 | 9.73 | 1164 | 209276 | 198457 | 50196227 |
Mania | 59.75 | 9.73 | 137 | 210303 | 10779 | 50383905 |
Nasal turbinate hypertrophy | 58.91 | 9.73 | 36 | 210404 | 634 | 50394050 |
Interstitial lung disease | 58.83 | 9.73 | 81 | 210359 | 53095 | 50341589 |
Bone marrow failure | 58.21 | 9.73 | 21 | 210419 | 27603 | 50367081 |
Alanine aminotransferase increased | 56.96 | 9.73 | 590 | 209850 | 87769 | 50306915 |
Ill-defined disorder | 55.83 | 9.73 | 88 | 210352 | 54566 | 50340118 |
Gastrointestinal disorder | 55.22 | 9.73 | 204 | 210236 | 94252 | 50300432 |
Sopor | 54.19 | 9.73 | 194 | 210246 | 19685 | 50374999 |
White blood cell count decreased | 53.68 | 9.73 | 276 | 210164 | 116446 | 50278238 |
Intentional self-injury | 53.45 | 9.73 | 214 | 210226 | 22898 | 50371786 |
Hallucination, visual | 53.28 | 9.73 | 171 | 210269 | 16411 | 50378273 |
Renal failure | 53.17 | 9.73 | 245 | 210195 | 106388 | 50288296 |
Therapy interrupted | 52.68 | 9.73 | 194 | 210246 | 19958 | 50374726 |
Dry mouth | 51.52 | 9.73 | 405 | 210035 | 55773 | 50338911 |
Atrial fibrillation | 51.19 | 9.73 | 233 | 210207 | 101512 | 50293172 |
Sleep apnoea syndrome | 50.47 | 9.73 | 215 | 210225 | 23653 | 50371031 |
Prescribed overdose | 50.08 | 9.73 | 154 | 210286 | 14446 | 50380238 |
Red blood cell sedimentation rate abnormal | 49.92 | 9.73 | 5 | 210435 | 16338 | 50378346 |
Cytomegalovirus infection | 48.83 | 9.73 | 8 | 210432 | 17954 | 50376730 |
Multiple organ dysfunction syndrome | 47.76 | 9.73 | 85 | 210355 | 50252 | 50344432 |
Hyperkalaemia | 47.64 | 9.73 | 79 | 210361 | 48010 | 50346674 |
Intervertebral discitis | 47.59 | 9.73 | 57 | 210383 | 2599 | 50392085 |
Seizure | 46.36 | 9.73 | 718 | 209722 | 117156 | 50277528 |
Coma blister | 45.93 | 9.73 | 19 | 210421 | 136 | 50394548 |
Device expulsion | 45.62 | 9.73 | 32 | 210408 | 28790 | 50365894 |
Neck deformity | 44.90 | 9.73 | 48 | 210392 | 1930 | 50392754 |
Extremity contracture | 44.85 | 9.73 | 39 | 210401 | 1209 | 50393475 |
Hypocalcaemia | 44.84 | 9.73 | 28 | 210412 | 26788 | 50367896 |
Hypotension | 44.76 | 9.73 | 699 | 209741 | 234770 | 50159914 |
Death | 44.26 | 9.73 | 1023 | 209417 | 324356 | 50070328 |
Pulmonary malformation | 43.77 | 9.73 | 20 | 210420 | 187 | 50394497 |
Gastrointestinal haemorrhage | 43.75 | 9.73 | 157 | 210283 | 73164 | 50321520 |
Vision blurred | 43.28 | 9.73 | 509 | 209931 | 78138 | 50316546 |
Cardiac failure congestive | 43.18 | 9.73 | 192 | 210248 | 84190 | 50310494 |
Pulmonary fibrosis | 43.00 | 9.73 | 24 | 210416 | 24413 | 50370271 |
Dyskinesia | 42.92 | 9.73 | 229 | 210211 | 27632 | 50367052 |
Bronchial neoplasm | 42.57 | 9.73 | 25 | 210415 | 408 | 50394276 |
Influenza like illness | 42.55 | 9.73 | 395 | 210045 | 57064 | 50337620 |
Muscle twitching | 42.41 | 9.73 | 151 | 210289 | 15280 | 50379404 |
Restlessness | 42.31 | 9.73 | 212 | 210228 | 24961 | 50369723 |
Irritable bowel syndrome | 41.84 | 9.73 | 95 | 210345 | 51346 | 50343338 |
Personality disorder | 41.78 | 9.73 | 69 | 210371 | 4255 | 50390429 |
Colitis microscopic | 41.55 | 9.73 | 87 | 210353 | 6433 | 50388251 |
Pulmonary oedema | 40.93 | 9.73 | 89 | 210351 | 48849 | 50345835 |
Aspartate aminotransferase increased | 40.38 | 9.73 | 499 | 209941 | 77499 | 50317185 |
Surgery | 39.75 | 9.73 | 238 | 210202 | 29967 | 50364717 |
Nervousness | 39.72 | 9.73 | 223 | 210217 | 27428 | 50367256 |
Opsoclonus myoclonus | 38.86 | 9.73 | 16 | 210424 | 113 | 50394571 |
Lactic acidosis | 38.74 | 9.73 | 49 | 210391 | 33306 | 50361378 |
Rheumatoid nodule | 38.63 | 9.73 | 4 | 210436 | 12731 | 50381953 |
Neck mass | 38.52 | 9.73 | 58 | 210382 | 3303 | 50391381 |
Bronchial haemorrhage | 38.36 | 9.73 | 25 | 210415 | 495 | 50394189 |
Product use in unapproved indication | 38.28 | 9.73 | 303 | 210137 | 115516 | 50279168 |
Urinary retention | 38.14 | 9.73 | 212 | 210228 | 25978 | 50368706 |
Neoplasm progression | 38.03 | 9.73 | 39 | 210401 | 29118 | 50365566 |
Weight increased | 37.47 | 9.73 | 1102 | 209338 | 200789 | 50193895 |
Pruritus | 37.31 | 9.73 | 896 | 209544 | 282672 | 50112012 |
Paranoia | 37.23 | 9.73 | 111 | 210329 | 10237 | 50384447 |
Hyperreflexia | 37.04 | 9.73 | 72 | 210368 | 5046 | 50389638 |
Hot flush | 37.02 | 9.73 | 312 | 210128 | 43857 | 50350827 |
Respiratory failure | 36.80 | 9.73 | 225 | 210215 | 90956 | 50303728 |
Hyperaesthesia | 36.65 | 9.73 | 95 | 210345 | 8078 | 50386606 |
Oedema peripheral | 36.39 | 9.73 | 451 | 209989 | 157510 | 50237174 |
Temperature intolerance | 36.27 | 9.73 | 90 | 210350 | 7449 | 50387235 |
Hip arthroplasty | 36.08 | 9.73 | 44 | 210396 | 30385 | 50364299 |
Rubber sensitivity | 36.05 | 9.73 | 41 | 210399 | 1768 | 50392916 |
Concussion | 35.58 | 9.73 | 90 | 210350 | 7538 | 50387146 |
Condition aggravated | 35.49 | 9.73 | 952 | 209488 | 296106 | 50098578 |
Mental disorder | 35.42 | 9.73 | 183 | 210257 | 21808 | 50372876 |
Rapid eye movements sleep abnormal | 35.39 | 9.73 | 15 | 210425 | 115 | 50394569 |
Tachyphrenia | 35.17 | 9.73 | 34 | 210406 | 1211 | 50393473 |
Balance disorder | 35.00 | 9.73 | 448 | 209992 | 70142 | 50324542 |
Metabolic surgery | 34.96 | 9.73 | 31 | 210409 | 987 | 50393697 |
Hypersomnia | 34.77 | 9.73 | 141 | 210299 | 15173 | 50379511 |
Gastrooesophageal reflux disease | 34.15 | 9.73 | 476 | 209964 | 75952 | 50318732 |
Live birth | 33.69 | 9.73 | 13 | 210427 | 16395 | 50378289 |
Palmar-plantar erythrodysaesthesia syndrome | 33.58 | 9.73 | 21 | 210419 | 20077 | 50374607 |
Pre-existing condition improved | 33.38 | 9.73 | 84 | 210356 | 7013 | 50387671 |
Blood pressure increased | 33.26 | 9.73 | 756 | 209684 | 132376 | 50262308 |
Hostility | 33.18 | 9.73 | 39 | 210401 | 1743 | 50392941 |
C-reactive protein increased | 32.96 | 9.73 | 153 | 210287 | 66321 | 50328363 |
Impaired driving ability | 32.75 | 9.73 | 59 | 210381 | 3902 | 50390782 |
Morbid thoughts | 32.68 | 9.73 | 23 | 210417 | 519 | 50394165 |
Product dose omission issue | 32.63 | 9.73 | 998 | 209442 | 182840 | 50211844 |
Therapy cessation | 32.36 | 9.73 | 202 | 210238 | 25809 | 50368875 |
Dehydration | 32.27 | 9.73 | 443 | 209997 | 152006 | 50242678 |
Akathisia | 32.23 | 9.73 | 91 | 210349 | 8138 | 50386546 |
Psoriasis | 31.75 | 9.73 | 432 | 210008 | 68568 | 50326116 |
Libido decreased | 31.60 | 9.73 | 44 | 210396 | 2332 | 50392352 |
Disorientation | 31.54 | 9.73 | 254 | 210186 | 35230 | 50359454 |
Sacroiliitis | 31.46 | 9.73 | 46 | 210394 | 2551 | 50392133 |
Vomiting | 31.32 | 9.73 | 2271 | 208169 | 458487 | 49936197 |
Hypomagnesaemia | 31.32 | 9.73 | 30 | 210410 | 23126 | 50371558 |
Epistaxis | 31.24 | 9.73 | 148 | 210292 | 63806 | 50330878 |
Lung cyst | 31.20 | 9.73 | 15 | 210425 | 159 | 50394525 |
Pulmonary eosinophilia | 31.19 | 9.73 | 16 | 210424 | 197 | 50394487 |
Endometrial ablation | 31.08 | 9.73 | 27 | 210413 | 836 | 50393848 |
Reversible cerebral vasoconstriction syndrome | 30.85 | 9.73 | 41 | 210399 | 2078 | 50392606 |
Melaena | 30.64 | 9.73 | 40 | 210400 | 26824 | 50367860 |
Rebound nasal congestion | 30.57 | 9.73 | 9 | 210431 | 18 | 50394666 |
Drug resistance | 30.16 | 9.73 | 21 | 210419 | 18968 | 50375716 |
Stiff person syndrome | 29.97 | 9.73 | 16 | 210424 | 215 | 50394469 |
Anorgasmia | 29.91 | 9.73 | 22 | 210418 | 533 | 50394151 |
Bradycardia | 29.79 | 9.73 | 152 | 210288 | 64274 | 50330410 |
Psychotic disorder due to a general medical condition | 29.77 | 9.73 | 16 | 210424 | 218 | 50394466 |
Bipolar disorder | 29.74 | 9.73 | 78 | 210362 | 6679 | 50388005 |
Libido increased | 29.70 | 9.73 | 31 | 210409 | 1212 | 50393472 |
Delusion | 29.54 | 9.73 | 104 | 210336 | 10465 | 50384219 |
Transplant rejection | 29.19 | 9.73 | 3 | 210437 | 9606 | 50385078 |
Thunderclap headache | 28.99 | 9.73 | 14 | 210426 | 150 | 50394534 |
Bruxism | 28.69 | 9.73 | 48 | 210392 | 2992 | 50391692 |
Formication | 28.50 | 9.73 | 53 | 210387 | 3593 | 50391091 |
Dissociation | 28.37 | 9.73 | 41 | 210399 | 2250 | 50392434 |
Cough | 28.33 | 9.73 | 775 | 209665 | 240489 | 50154195 |
Oesophageal spasm | 28.30 | 9.73 | 41 | 210399 | 2255 | 50392429 |
Cognitive disorder | 28.12 | 9.73 | 294 | 210146 | 43829 | 50350855 |
Tearfulness | 28.07 | 9.73 | 53 | 210387 | 3634 | 50391050 |
Speech disorder | 27.65 | 9.73 | 247 | 210193 | 35301 | 50359383 |
Gastric banding | 27.55 | 9.73 | 11 | 210429 | 71 | 50394613 |
Nasopharyngitis | 27.48 | 9.73 | 602 | 209838 | 192325 | 50202359 |
Haemoptysis | 27.24 | 9.73 | 40 | 210400 | 25533 | 50369151 |
Telangiectasia congenital | 27.17 | 9.73 | 8 | 210432 | 16 | 50394668 |
Metastases to bone | 27.15 | 9.73 | 21 | 210419 | 17974 | 50376710 |
Rash maculo-papular | 27.10 | 9.73 | 43 | 210397 | 26598 | 50368086 |
Macular degeneration | 26.99 | 9.73 | 13 | 210427 | 14375 | 50380309 |
Blood calcium decreased | 26.66 | 9.73 | 28 | 210412 | 20678 | 50374006 |
Complex regional pain syndrome | 26.65 | 9.73 | 37 | 210403 | 1956 | 50392728 |
Loss of libido | 26.57 | 9.73 | 29 | 210411 | 1194 | 50393490 |
Gastrostomy | 26.45 | 9.73 | 20 | 210420 | 506 | 50394178 |
Psychotic disorder | 26.27 | 9.73 | 168 | 210272 | 21644 | 50373040 |
Acute myeloid leukaemia | 26.24 | 9.73 | 15 | 210425 | 15059 | 50379625 |
Pneumonitis | 26.08 | 9.73 | 52 | 210388 | 29458 | 50365226 |
Bone density abnormal | 26.01 | 9.73 | 46 | 210394 | 2999 | 50391685 |
Psychomotor hyperactivity | 25.54 | 9.73 | 91 | 210349 | 9210 | 50385474 |
Proteinuria | 25.52 | 9.73 | 19 | 210421 | 16578 | 50378106 |
Agranulocytosis | 25.37 | 9.73 | 31 | 210409 | 21390 | 50373294 |
Head injury | 25.32 | 9.73 | 179 | 210261 | 23841 | 50370843 |
Metastases to liver | 24.98 | 9.73 | 28 | 210412 | 20076 | 50374608 |
Anovulatory cycle | 24.81 | 9.73 | 12 | 210428 | 129 | 50394555 |
Sleep terror | 24.79 | 9.73 | 22 | 210418 | 701 | 50393983 |
Mobility decreased | 24.66 | 9.73 | 213 | 210227 | 79735 | 50314949 |
Autonomic dysreflexia | 24.63 | 9.73 | 16 | 210424 | 315 | 50394369 |
Pregnancy | 24.56 | 9.73 | 54 | 210386 | 29523 | 50365161 |
Emotional disorder | 24.55 | 9.73 | 106 | 210334 | 11730 | 50382954 |
Acute respiratory distress syndrome | 24.50 | 9.73 | 31 | 210409 | 21068 | 50373616 |
Thrombotic microangiopathy | 23.71 | 9.73 | 4 | 210436 | 8787 | 50385897 |
Deep vein thrombosis | 23.65 | 9.73 | 193 | 210247 | 73111 | 50321573 |
Drug hypersensitivity | 23.42 | 9.73 | 1272 | 209168 | 249738 | 50144946 |
Skin necrosis | 23.34 | 9.73 | 8 | 210432 | 10859 | 50383825 |
Coronary artery disease | 23.28 | 9.73 | 56 | 210384 | 29670 | 50365014 |
Torsade de pointes | 23.28 | 9.73 | 10 | 210430 | 11825 | 50382859 |
Neuralgia | 23.09 | 9.73 | 163 | 210277 | 21700 | 50372984 |
Major depression | 23.04 | 9.73 | 72 | 210368 | 6812 | 50387872 |
Cerebral infarction | 22.81 | 9.73 | 34 | 210406 | 21570 | 50373114 |
Ejection fraction decreased | 22.79 | 9.73 | 26 | 210414 | 18494 | 50376190 |
Anaphylactic reaction | 22.54 | 9.73 | 132 | 210308 | 53923 | 50340761 |
Respiratory tract malformation | 22.51 | 9.73 | 10 | 210430 | 87 | 50394597 |
Arthralgia | 22.42 | 9.73 | 1547 | 208893 | 437155 | 49957529 |
Disseminated intravascular coagulation | 22.25 | 9.73 | 23 | 210417 | 17112 | 50377572 |
Depressive symptom | 21.93 | 9.73 | 44 | 210396 | 3156 | 50391528 |
Hypokalaemia | 21.87 | 9.73 | 247 | 210193 | 87745 | 50306939 |
Flat affect | 21.75 | 9.73 | 27 | 210413 | 1278 | 50393406 |
Decreased interest | 21.70 | 9.73 | 42 | 210398 | 2934 | 50391750 |
Circulatory collapse | 21.58 | 9.73 | 31 | 210409 | 19969 | 50374715 |
Foetal death | 21.46 | 9.73 | 4 | 210436 | 8176 | 50386508 |
Hallucination, auditory | 21.43 | 9.73 | 95 | 210345 | 10633 | 50384051 |
Bronchial disorder | 21.27 | 9.73 | 25 | 210415 | 1117 | 50393567 |
Hypoglycaemia | 21.21 | 9.73 | 133 | 210307 | 53448 | 50341236 |
Myelodysplastic syndrome | 21.18 | 9.73 | 19 | 210421 | 15113 | 50379571 |
Mydriasis | 21.14 | 9.73 | 94 | 210346 | 10533 | 50384151 |
Liver function test increased | 21.05 | 9.73 | 47 | 210393 | 25559 | 50369125 |
Right ventricular failure | 21.02 | 9.73 | 21 | 210419 | 15872 | 50378812 |
Ankle fracture | 20.76 | 9.73 | 124 | 210316 | 15598 | 50379086 |
Hypoxia | 20.70 | 9.73 | 126 | 210314 | 50997 | 50343687 |
Middle insomnia | 20.69 | 9.73 | 89 | 210351 | 9832 | 50384852 |
Tenosynovitis | 20.67 | 9.73 | 9 | 210431 | 10556 | 50384128 |
Inflammation | 20.65 | 9.73 | 145 | 210295 | 56767 | 50337917 |
Therapy non-responder | 20.53 | 9.73 | 126 | 210314 | 50896 | 50343788 |
Hypoaesthesia | 20.51 | 9.73 | 683 | 209757 | 126574 | 50268110 |
Respiratory distress | 20.44 | 9.73 | 62 | 210378 | 30427 | 50364257 |
Granulomatous liver disease | 20.44 | 9.73 | 20 | 210420 | 723 | 50393961 |
Haematotoxicity | 20.41 | 9.73 | 4 | 210436 | 7891 | 50386793 |
Pulmonary congestion | 20.33 | 9.73 | 20 | 210420 | 15227 | 50379457 |
Therapeutic response changed | 20.31 | 9.73 | 21 | 210419 | 812 | 50393872 |
Asphyxia | 20.27 | 9.73 | 59 | 210381 | 5368 | 50389316 |
Gait disturbance | 20.23 | 9.73 | 789 | 209651 | 149216 | 50245468 |
Tension | 20.16 | 9.73 | 39 | 210401 | 2723 | 50391961 |
Antinuclear antibody negative | 20.01 | 9.73 | 12 | 210428 | 204 | 50394480 |
Basal cell carcinoma | 19.92 | 9.73 | 42 | 210398 | 23314 | 50371370 |
Aplastic anaemia | 19.71 | 9.73 | 4 | 210436 | 7699 | 50386985 |
Red blood cell sedimentation rate increased | 19.59 | 9.73 | 60 | 210380 | 29356 | 50365328 |
Galactorrhoea | 19.58 | 9.73 | 46 | 210394 | 3677 | 50391007 |
Coombs positive haemolytic anaemia | 19.55 | 9.73 | 14 | 210426 | 325 | 50394359 |
Drug tolerance decreased | 19.24 | 9.73 | 7 | 210433 | 9153 | 50385531 |
Premature labour | 19.16 | 9.73 | 12 | 210428 | 11464 | 50383220 |
Tubulointerstitial nephritis | 19.10 | 9.73 | 21 | 210419 | 15190 | 50379494 |
Hypercalcaemia | 19.09 | 9.73 | 43 | 210397 | 23309 | 50371375 |
Homicidal ideation | 18.98 | 9.73 | 29 | 210411 | 1673 | 50393011 |
Drug screen positive | 18.95 | 9.73 | 43 | 210397 | 3359 | 50391325 |
Conversion disorder | 18.95 | 9.73 | 28 | 210412 | 1568 | 50393116 |
Phagophobia | 18.85 | 9.73 | 7 | 210433 | 36 | 50394648 |
Exposure via breast milk | 18.79 | 9.73 | 28 | 210412 | 1580 | 50393104 |
Hypnopompic hallucination | 18.69 | 9.73 | 7 | 210433 | 37 | 50394647 |
Heart rate decreased | 18.69 | 9.73 | 83 | 210357 | 36414 | 50358270 |
Pneumocystis jirovecii pneumonia | 18.69 | 9.73 | 20 | 210420 | 14643 | 50380041 |
Panic disorder | 18.66 | 9.73 | 34 | 210406 | 2269 | 50392415 |
Alcoholism | 18.63 | 9.73 | 28 | 210412 | 1592 | 50393092 |
Aspergillus infection | 18.63 | 9.73 | 3 | 210437 | 6818 | 50387866 |
Dysphemia | 18.63 | 9.73 | 34 | 210406 | 2272 | 50392412 |
Shock | 18.58 | 9.73 | 36 | 210404 | 20614 | 50374070 |
Bipolar I disorder | 18.55 | 9.73 | 27 | 210413 | 1491 | 50393193 |
Toxic epidermal necrolysis | 18.54 | 9.73 | 37 | 210403 | 20955 | 50373729 |
Hyperglycaemia | 18.52 | 9.73 | 83 | 210357 | 36322 | 50358362 |
Angioedema | 18.51 | 9.73 | 87 | 210353 | 37589 | 50357095 |
Tic | 18.42 | 9.73 | 24 | 210416 | 1193 | 50393491 |
Skin haemorrhage | 18.42 | 9.73 | 67 | 210373 | 6851 | 50387833 |
Depression suicidal | 18.40 | 9.73 | 27 | 210413 | 1502 | 50393182 |
Myoclonus | 18.39 | 9.73 | 113 | 210327 | 14357 | 50380327 |
Impulse-control disorder | 18.37 | 9.73 | 18 | 210422 | 652 | 50394032 |
Hypoalbuminaemia | 18.36 | 9.73 | 9 | 210431 | 9851 | 50384833 |
Demyelination | 18.33 | 9.73 | 61 | 210379 | 5965 | 50388719 |
Haemodialysis | 18.23 | 9.73 | 6 | 210434 | 8356 | 50386328 |
Clonus | 18.18 | 9.73 | 48 | 210392 | 4127 | 50390557 |
Eosinophilia | 18.14 | 9.73 | 31 | 210409 | 18621 | 50376063 |
Knee arthroplasty | 18.07 | 9.73 | 82 | 210358 | 35764 | 50358920 |
Bacteraemia | 18.04 | 9.73 | 20 | 210420 | 14413 | 50380271 |
Cardiogenic shock | 18.02 | 9.73 | 23 | 210417 | 15576 | 50379108 |
Intentional dose omission | 18.00 | 9.73 | 54 | 210386 | 4996 | 50389688 |
Metastases to lung | 17.75 | 9.73 | 12 | 210428 | 11008 | 50383676 |
Feelings of worthlessness | 17.75 | 9.73 | 13 | 210427 | 313 | 50394371 |
Tuberculosis | 17.60 | 9.73 | 10 | 210430 | 10073 | 50384611 |
Pustular psoriasis | 17.57 | 9.73 | 46 | 210394 | 3935 | 50390749 |
Apathy | 17.54 | 9.73 | 70 | 210370 | 7478 | 50387206 |
Blood cholesterol increased | 17.52 | 9.73 | 146 | 210294 | 55069 | 50339615 |
Cholestasis | 17.50 | 9.73 | 51 | 210389 | 25350 | 50369334 |
Drug eruption | 17.30 | 9.73 | 46 | 210394 | 23560 | 50371124 |
Metabolic acidosis | 17.16 | 9.73 | 93 | 210347 | 38732 | 50355952 |
Toxic skin eruption | 17.14 | 9.73 | 13 | 210427 | 11238 | 50383446 |
Arteriosclerosis coronary artery | 17.09 | 9.73 | 70 | 210370 | 7566 | 50387118 |
CYP3A4 polymorphism | 17.04 | 9.73 | 8 | 210432 | 80 | 50394604 |
Dyspnoea exertional | 16.93 | 9.73 | 134 | 210306 | 51099 | 50343585 |
Self-injurious ideation | 16.92 | 9.73 | 32 | 210408 | 2197 | 50392487 |
Second primary malignancy | 16.86 | 9.73 | 4 | 210436 | 6910 | 50387774 |
Dysphagia | 16.86 | 9.73 | 432 | 210008 | 77086 | 50317598 |
Muscle spasms | 16.83 | 9.73 | 660 | 209780 | 124893 | 50269791 |
Polyarthritis | 16.74 | 9.73 | 6 | 210434 | 7921 | 50386763 |
Hyponatraemic encephalopathy | 16.65 | 9.73 | 11 | 210429 | 223 | 50394461 |
Diplopia | 16.64 | 9.73 | 137 | 210303 | 19123 | 50375561 |
Myocardial infarction | 16.64 | 9.73 | 265 | 210175 | 88762 | 50305922 |
Osteonecrosis of jaw | 16.64 | 9.73 | 74 | 210366 | 32452 | 50362232 |
Sleep talking | 16.63 | 9.73 | 20 | 210420 | 916 | 50393768 |
Pulseless electrical activity | 16.60 | 9.73 | 4 | 210436 | 6837 | 50387847 |
Drug abuse | 16.58 | 9.73 | 345 | 210095 | 59501 | 50335183 |
Panic reaction | 16.53 | 9.73 | 42 | 210398 | 3527 | 50391157 |
Hyperacusis | 16.38 | 9.73 | 28 | 210412 | 1776 | 50392908 |
Abdominal pain | 16.36 | 9.73 | 809 | 209631 | 235419 | 50159265 |
Hypervolaemia | 16.29 | 9.73 | 53 | 210387 | 25446 | 50369238 |
Spinal operation | 16.14 | 9.73 | 60 | 210380 | 6200 | 50388484 |
Accidental exposure to product | 16.10 | 9.73 | 46 | 210394 | 23011 | 50371673 |
Cataplexy | 16.10 | 9.73 | 21 | 210419 | 1045 | 50393639 |
Oliguria | 16.07 | 9.73 | 7 | 210433 | 8209 | 50386475 |
Fear of injection | 15.97 | 9.73 | 3 | 210437 | 6100 | 50388584 |
Road traffic accident | 15.86 | 9.73 | 163 | 210277 | 24189 | 50370495 |
Poor quality sleep | 15.80 | 9.73 | 121 | 210319 | 16525 | 50378159 |
Poisoning | 15.76 | 9.73 | 97 | 210343 | 12332 | 50382352 |
Mean cell haemoglobin concentration increased | 15.57 | 9.73 | 14 | 210426 | 454 | 50394230 |
Device related infection | 15.51 | 9.73 | 40 | 210400 | 20695 | 50373989 |
Intervertebral disc protrusion | 15.50 | 9.73 | 141 | 210299 | 20252 | 50374432 |
Metastases to lymph nodes | 15.39 | 9.73 | 5 | 210435 | 7019 | 50387665 |
Pulmonary haemorrhage | 15.36 | 9.73 | 4 | 210436 | 6488 | 50388196 |
Haemorrhage | 15.33 | 9.73 | 145 | 210295 | 53296 | 50341388 |
Lactation disorder | 15.27 | 9.73 | 12 | 210428 | 322 | 50394362 |
Gastric ulcer | 15.25 | 9.73 | 42 | 210398 | 21263 | 50373421 |
Decreased appetite | 15.12 | 9.73 | 682 | 209758 | 200241 | 50194443 |
Neurologic neglect syndrome | 15.08 | 9.73 | 24 | 210416 | 1434 | 50393250 |
Ischaemic stroke | 15.06 | 9.73 | 27 | 210413 | 15921 | 50378763 |
Sensitivity to weather change | 15.04 | 9.73 | 57 | 210383 | 5944 | 50388740 |
Transfusion | 14.94 | 9.73 | 19 | 210421 | 12886 | 50381798 |
Congenital tricuspid valve atresia | 14.87 | 9.73 | 6 | 210434 | 40 | 50394644 |
Bone erosion | 14.83 | 9.73 | 16 | 210424 | 11671 | 50383013 |
Metastases to central nervous system | 14.81 | 9.73 | 15 | 210425 | 11267 | 50383417 |
Maternal exposure during breast feeding | 14.77 | 9.73 | 38 | 210402 | 3216 | 50391468 |
Acute myocardial infarction | 14.73 | 9.73 | 67 | 210373 | 29206 | 50365478 |
Impatience | 14.65 | 9.73 | 12 | 210428 | 342 | 50394342 |
Carotid artery thrombosis | 14.59 | 9.73 | 24 | 210416 | 1475 | 50393209 |
Spondyloarthropathy | 14.55 | 9.73 | 17 | 210423 | 755 | 50393929 |
Red blood cell count decreased | 14.44 | 9.73 | 82 | 210358 | 33753 | 50360931 |
Urinary incontinence | 14.39 | 9.73 | 180 | 210260 | 28028 | 50366656 |
Caesarean section | 14.30 | 9.73 | 27 | 210413 | 15612 | 50379072 |
Creatinine renal clearance decreased | 14.27 | 9.73 | 17 | 210423 | 11864 | 50382820 |
Naevus flammeus | 14.27 | 9.73 | 8 | 210432 | 119 | 50394565 |
Bradyphrenia | 14.25 | 9.73 | 57 | 210383 | 6095 | 50388589 |
Gambling disorder | 14.25 | 9.73 | 21 | 210419 | 1173 | 50393511 |
Lung diffusion test decreased | 14.22 | 9.73 | 15 | 210425 | 594 | 50394090 |
Feeling of despair | 14.13 | 9.73 | 28 | 210412 | 1990 | 50392694 |
Oesophageal pain | 14.06 | 9.73 | 34 | 210406 | 2768 | 50391916 |
Intrusive thoughts | 14.04 | 9.73 | 9 | 210431 | 173 | 50394511 |
Oesophageal food impaction | 14.04 | 9.73 | 9 | 210431 | 173 | 50394511 |
Overdose | 14.02 | 9.73 | 527 | 209913 | 99200 | 50295484 |
Post-traumatic neck syndrome | 13.98 | 9.73 | 27 | 210413 | 1883 | 50392801 |
Lung disorder | 13.97 | 9.73 | 119 | 210321 | 44680 | 50350004 |
Hepatic steatosis | 13.93 | 9.73 | 159 | 210281 | 24225 | 50370459 |
Pulmonary arterial hypertension | 13.85 | 9.73 | 41 | 210399 | 20278 | 50374406 |
Haemolytic anaemia | 13.82 | 9.73 | 11 | 210429 | 9281 | 50385403 |
Intentional overdose | 13.79 | 9.73 | 349 | 210091 | 62155 | 50332529 |
Trigeminal neuralgia | 13.75 | 9.73 | 36 | 210404 | 3079 | 50391605 |
Scoliosis | 13.72 | 9.73 | 59 | 210381 | 6517 | 50388167 |
Uraemic encephalopathy | 13.69 | 9.73 | 9 | 210431 | 181 | 50394503 |
Scar | 13.60 | 9.73 | 90 | 210350 | 11728 | 50382956 |
Exposure during pregnancy | 13.60 | 9.73 | 391 | 210049 | 120624 | 50274060 |
Immunisation reaction | 13.58 | 9.73 | 5 | 210435 | 25 | 50394659 |
Tumour lysis syndrome | 13.48 | 9.73 | 7 | 210433 | 7414 | 50387270 |
Stillbirth | 13.46 | 9.73 | 4 | 210436 | 5948 | 50388736 |
Clitoral engorgement | 13.46 | 9.73 | 3 | 210437 | 0 | 50394684 |
Phobia of driving | 13.46 | 9.73 | 3 | 210437 | 0 | 50394684 |
Herpes simplex reactivation | 13.45 | 9.73 | 12 | 210428 | 385 | 50394299 |
Rales | 13.41 | 9.73 | 13 | 210427 | 9965 | 50384719 |
Gun shot wound | 13.38 | 9.73 | 7 | 210433 | 90 | 50394594 |
Enterococcal infection | 13.30 | 9.73 | 6 | 210434 | 6892 | 50387792 |
Haematuria | 13.26 | 9.73 | 58 | 210382 | 25555 | 50369129 |
Pulmonary hypertension | 13.20 | 9.73 | 83 | 210357 | 33334 | 50361350 |
Tachyphylaxis | 13.19 | 9.73 | 10 | 210430 | 254 | 50394430 |
Hepatobiliary scan abnormal | 13.14 | 9.73 | 6 | 210434 | 56 | 50394628 |
Autonomic nervous system imbalance | 13.12 | 9.73 | 30 | 210410 | 2355 | 50392329 |
Hepatitis C antibody positive | 13.05 | 9.73 | 7 | 210433 | 95 | 50394589 |
Pseudomonas infection | 13.01 | 9.73 | 12 | 210428 | 9418 | 50385266 |
Feeling drunk | 12.96 | 9.73 | 39 | 210401 | 3614 | 50391070 |
Polyneuropathy | 12.90 | 9.73 | 19 | 210421 | 12112 | 50382572 |
Immobilisation prolonged | 12.86 | 9.73 | 7 | 210433 | 98 | 50394586 |
Urinary hesitation | 12.84 | 9.73 | 27 | 210413 | 2002 | 50392682 |
Leukopenia neonatal | 12.83 | 9.73 | 5 | 210435 | 30 | 50394654 |
Holmes-Adie pupil | 12.83 | 9.73 | 5 | 210435 | 30 | 50394654 |
Ophthalmic vein thrombosis | 12.79 | 9.73 | 8 | 210432 | 147 | 50394537 |
Rhonchi | 12.67 | 9.73 | 29 | 210411 | 2278 | 50392406 |
Muscular weakness | 12.62 | 9.73 | 499 | 209941 | 94514 | 50300170 |
Pathogen resistance | 12.55 | 9.73 | 4 | 210436 | 5685 | 50388999 |
Diffuse large B-cell lymphoma | 12.46 | 9.73 | 4 | 210436 | 5658 | 50389026 |
Drug metabolising enzyme decreased | 12.45 | 9.73 | 4 | 210436 | 12 | 50394672 |
Cerebral haemorrhage | 12.40 | 9.73 | 64 | 210376 | 26988 | 50367696 |
Respiratory tract infection | 12.40 | 9.73 | 80 | 210360 | 31937 | 50362747 |
Femur fracture | 12.37 | 9.73 | 98 | 210342 | 37366 | 50357318 |
Fear | 12.31 | 9.73 | 103 | 210337 | 14446 | 50380238 |
Radiation fibrosis | 12.31 | 9.73 | 5 | 210435 | 34 | 50394650 |
Sedation complication | 12.28 | 9.73 | 11 | 210429 | 8755 | 50385929 |
Blood lactate dehydrogenase increased | 12.26 | 9.73 | 41 | 210399 | 19521 | 50375163 |
Soft tissue injury | 12.14 | 9.73 | 22 | 210418 | 1462 | 50393222 |
Intentional product use issue | 12.12 | 9.73 | 236 | 210204 | 76682 | 50318002 |
Oedema | 12.10 | 9.73 | 212 | 210228 | 69969 | 50324715 |
Lupus-like syndrome | 12.03 | 9.73 | 13 | 210427 | 9478 | 50385206 |
Adverse event | 12.02 | 9.73 | 120 | 210320 | 43643 | 50351041 |
Blood alkaline phosphatase increased | 11.97 | 9.73 | 221 | 210219 | 37305 | 50357379 |
Progressive multifocal leukoencephalopathy | 11.85 | 9.73 | 85 | 210355 | 11372 | 50383312 |
Phonophobia | 11.80 | 9.73 | 10 | 210430 | 299 | 50394385 |
Adjustment disorder | 11.79 | 9.73 | 26 | 210414 | 1993 | 50392691 |
Escherichia infection | 11.76 | 9.73 | 17 | 210423 | 10924 | 50383760 |
Liver injury | 11.76 | 9.73 | 58 | 210382 | 24748 | 50369936 |
Cataract | 11.66 | 9.73 | 133 | 210307 | 47167 | 50347517 |
Electric shock sensation | 11.63 | 9.73 | 9 | 210431 | 236 | 50394448 |
Abortion induced | 11.62 | 9.73 | 13 | 210427 | 9331 | 50385353 |
Chest discomfort | 11.61 | 9.73 | 295 | 210145 | 92427 | 50302257 |
Hepatotoxicity | 11.61 | 9.73 | 66 | 210374 | 27160 | 50367524 |
Pulmonary embolism | 11.58 | 9.73 | 328 | 210112 | 101376 | 50293308 |
Rotator cuff syndrome | 11.57 | 9.73 | 85 | 210355 | 11459 | 50383225 |
Eyelid myoclonus | 11.51 | 9.73 | 5 | 210435 | 41 | 50394643 |
Contusion | 11.48 | 9.73 | 367 | 210073 | 111816 | 50282868 |
Skin plaque | 11.45 | 9.73 | 6 | 210434 | 6322 | 50388362 |
Spasmodic dysphonia | 11.41 | 9.73 | 6 | 210434 | 78 | 50394606 |
Chronic idiopathic pain syndrome | 11.39 | 9.73 | 3 | 210437 | 3 | 50394681 |
Visual impairment | 11.39 | 9.73 | 368 | 210072 | 67907 | 50326777 |
Labelled drug-food interaction issue | 11.39 | 9.73 | 4 | 210436 | 17 | 50394667 |
Food craving | 11.35 | 9.73 | 21 | 210419 | 1418 | 50393266 |
Neuropsychiatric symptoms | 11.33 | 9.73 | 13 | 210427 | 566 | 50394118 |
Rapid eye movement sleep behaviour disorder | 11.31 | 9.73 | 8 | 210432 | 182 | 50394502 |
Disturbance in sexual arousal | 11.28 | 9.73 | 6 | 210434 | 80 | 50394604 |
Injection site haemorrhage | 11.26 | 9.73 | 48 | 210392 | 21298 | 50373386 |
Clostridium difficile colitis | 11.25 | 9.73 | 37 | 210403 | 17705 | 50376979 |
Vasculitis | 11.24 | 9.73 | 26 | 210414 | 13965 | 50380719 |
Nephrotic syndrome | 11.17 | 9.73 | 3 | 210437 | 4767 | 50389917 |
Oxygen saturation decreased | 11.16 | 9.73 | 226 | 210214 | 73022 | 50321662 |
Impulsive behaviour | 11.15 | 9.73 | 21 | 210419 | 1437 | 50393247 |
Sluggishness | 11.13 | 9.73 | 42 | 210398 | 4371 | 50390313 |
Polyglandular autoimmune syndrome type II | 11.11 | 9.73 | 5 | 210435 | 45 | 50394639 |
Feeling jittery | 11.09 | 9.73 | 82 | 210358 | 11078 | 50383606 |
Cushingoid | 11.02 | 9.73 | 7 | 210433 | 6638 | 50388046 |
Supraventricular tachyarrhythmia | 11.02 | 9.73 | 6 | 210434 | 84 | 50394600 |
Device difficult to use | 10.99 | 9.73 | 15 | 210425 | 9871 | 50384813 |
Infective pulmonary exacerbation of cystic fibrosis | 10.99 | 9.73 | 10 | 210430 | 7899 | 50386785 |
Cytomegalovirus viraemia | 10.96 | 9.73 | 3 | 210437 | 4706 | 50389978 |
Sciatic nerve injury | 10.95 | 9.73 | 11 | 210429 | 411 | 50394273 |
Skin ulcer | 10.93 | 9.73 | 94 | 210346 | 35224 | 50359460 |
Carcinoid tumour pulmonary | 10.92 | 9.73 | 11 | 210429 | 412 | 50394272 |
Bronchospasm | 10.85 | 9.73 | 29 | 210411 | 14825 | 50379859 |
Anaphylactic shock | 10.83 | 9.73 | 45 | 210395 | 20110 | 50374574 |
Sternal fracture | 10.82 | 9.73 | 25 | 210415 | 1977 | 50392707 |
Epstein-Barr virus infection | 10.77 | 9.73 | 8 | 210432 | 6989 | 50387695 |
Haemorrhage intracranial | 10.77 | 9.73 | 22 | 210418 | 12352 | 50382332 |
Suspected product quality issue | 10.77 | 9.73 | 8 | 210432 | 197 | 50394487 |
Cytokine release syndrome | 10.75 | 9.73 | 12 | 210428 | 8622 | 50386062 |
Pain in jaw | 10.71 | 9.73 | 105 | 210335 | 38323 | 50356361 |
Status epilepticus | 10.70 | 9.73 | 25 | 210415 | 13381 | 50381303 |
Foot amputation | 10.68 | 9.73 | 9 | 210431 | 267 | 50394417 |
Chronic obstructive pulmonary disease | 10.68 | 9.73 | 157 | 210283 | 53278 | 50341406 |
Pyometra | 10.66 | 9.73 | 6 | 210434 | 90 | 50394594 |
Hepatitis A antibody positive | 10.65 | 9.73 | 5 | 210435 | 50 | 50394634 |
Alveolar bone resorption | 10.65 | 9.73 | 5 | 210435 | 50 | 50394634 |
Blood pressure diastolic decreased | 10.64 | 9.73 | 35 | 210405 | 16746 | 50377938 |
Sexual dysfunction | 10.62 | 9.73 | 34 | 210406 | 3258 | 50391426 |
Blood pressure diastolic abnormal | 10.61 | 9.73 | 14 | 210426 | 9347 | 50385337 |
Ligament injury | 10.58 | 9.73 | 17 | 210423 | 1024 | 50393660 |
Mental impairment | 10.58 | 9.73 | 86 | 210354 | 11958 | 50382726 |
Purple glove syndrome | 10.49 | 9.73 | 8 | 210432 | 205 | 50394479 |
Psoriatic arthropathy | 10.49 | 9.73 | 263 | 210177 | 46769 | 50347915 |
Intestinal cyst | 10.49 | 9.73 | 6 | 210434 | 93 | 50394591 |
Rectal haemorrhage | 10.48 | 9.73 | 106 | 210334 | 38452 | 50356232 |
Pulmonary toxicity | 10.47 | 9.73 | 5 | 210435 | 5557 | 50389127 |
Productive cough | 10.47 | 9.73 | 155 | 210285 | 52539 | 50342145 |
Hypoventilation | 10.46 | 9.73 | 38 | 210402 | 3883 | 50390801 |
Haemolysis | 10.45 | 9.73 | 6 | 210434 | 6010 | 50388674 |
Ventricular hypoplasia | 10.38 | 9.73 | 7 | 210433 | 147 | 50394537 |
Accommodation disorder | 10.37 | 9.73 | 10 | 210430 | 355 | 50394329 |
Trigger finger | 10.35 | 9.73 | 37 | 210403 | 3751 | 50390933 |
Acute pulmonary oedema | 10.32 | 9.73 | 9 | 210431 | 7258 | 50387426 |
Atelectasis | 10.32 | 9.73 | 40 | 210400 | 18230 | 50376454 |
Eye pain | 10.31 | 9.73 | 171 | 210269 | 28278 | 50366406 |
Posterior reversible encephalopathy syndrome | 10.26 | 9.73 | 30 | 210410 | 14898 | 50379786 |
Central nervous system stimulation | 10.26 | 9.73 | 4 | 210436 | 24 | 50394660 |
Parosmia | 10.19 | 9.73 | 41 | 210399 | 4395 | 50390289 |
Hypophosphataemia | 10.15 | 9.73 | 12 | 210428 | 8402 | 50386282 |
Klebsiella infection | 10.11 | 9.73 | 9 | 210431 | 7185 | 50387499 |
Duodenal ulcer | 10.10 | 9.73 | 8 | 210432 | 6767 | 50387917 |
Dissociative disorder | 10.10 | 9.73 | 8 | 210432 | 217 | 50394467 |
Unintentional medical device removal | 10.06 | 9.73 | 5 | 210435 | 5430 | 50389254 |
Unintended pregnancy | 10.02 | 9.73 | 4 | 210436 | 4942 | 50389742 |
Suspected suicide attempt | 10.00 | 9.73 | 6 | 210434 | 102 | 50394582 |
Lymphadenopathy | 9.99 | 9.73 | 90 | 210350 | 33409 | 50361275 |
Haematocrit decreased | 9.99 | 9.73 | 95 | 210345 | 34881 | 50359803 |
Drug-induced liver injury | 9.98 | 9.73 | 72 | 210368 | 28023 | 50366661 |
Shock haemorrhagic | 9.96 | 9.73 | 12 | 210428 | 8332 | 50386352 |
Angina unstable | 9.90 | 9.73 | 8 | 210432 | 6698 | 50387986 |
Lung infiltration | 9.89 | 9.73 | 26 | 210414 | 13367 | 50381317 |
Lung neoplasm | 9.89 | 9.73 | 5 | 210435 | 5377 | 50389307 |
Pericardial effusion | 9.88 | 9.73 | 64 | 210376 | 25525 | 50369159 |
Self esteem decreased | 9.85 | 9.73 | 12 | 210428 | 557 | 50394127 |
Enuresis | 9.81 | 9.73 | 25 | 210415 | 2104 | 50392580 |
Myocardial ischaemia | 9.81 | 9.73 | 21 | 210419 | 11592 | 50383092 |
Large intestine perforation | 9.80 | 9.73 | 10 | 210430 | 7484 | 50387200 |
Anuria | 9.78 | 9.73 | 20 | 210420 | 11224 | 50383460 |
Chronic kidney disease | 9.74 | 9.73 | 112 | 210328 | 39659 | 50355025 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 1282.70 | 11.16 | 684 | 66993 | 17300 | 29489550 |
Dysphoria | 1235.67 | 11.16 | 368 | 67309 | 1724 | 29505126 |
Affect lability | 1153.15 | 11.16 | 392 | 67285 | 3010 | 29503840 |
Suicidal ideation | 766.64 | 11.16 | 635 | 67042 | 34081 | 29472769 |
Irritability | 671.48 | 11.16 | 489 | 67188 | 21663 | 29485187 |
Sensory disturbance | 564.59 | 11.16 | 269 | 67408 | 5300 | 29501550 |
Vertigo | 499.26 | 11.16 | 408 | 67269 | 21453 | 29485397 |
Paraesthesia | 490.68 | 11.16 | 610 | 67067 | 53235 | 29453615 |
Agitation | 475.15 | 11.16 | 586 | 67091 | 50718 | 29456132 |
Insomnia | 453.59 | 11.16 | 764 | 66913 | 87997 | 29418853 |
Hyperhidrosis | 407.32 | 11.16 | 612 | 67065 | 63928 | 29442922 |
Anxiety | 382.98 | 11.16 | 694 | 66983 | 84671 | 29422179 |
Nightmare | 354.77 | 11.16 | 256 | 67421 | 11161 | 29495689 |
Dizziness | 264.30 | 11.16 | 992 | 66685 | 188692 | 29318158 |
Tinnitus | 255.06 | 11.16 | 241 | 67436 | 15373 | 29491477 |
Hypomania | 235.58 | 11.16 | 110 | 67567 | 2065 | 29504785 |
Completed suicide | 234.85 | 11.16 | 588 | 67089 | 89658 | 29417192 |
Confusional state | 225.88 | 11.16 | 724 | 66953 | 127153 | 29379697 |
Tremor | 225.74 | 11.16 | 511 | 67166 | 73027 | 29433823 |
Lethargy | 220.78 | 11.16 | 345 | 67332 | 37235 | 29469615 |
Serotonin syndrome | 217.50 | 11.16 | 233 | 67444 | 17279 | 29489571 |
Mood swings | 214.81 | 11.16 | 158 | 67519 | 7093 | 29499757 |
Headache | 180.70 | 11.16 | 832 | 66845 | 173175 | 29333675 |
Nausea | 148.37 | 11.16 | 1149 | 66528 | 288106 | 29218744 |
Sleep disorder | 140.55 | 11.16 | 222 | 67455 | 24164 | 29482686 |
Suicide attempt | 132.36 | 11.16 | 261 | 67416 | 33849 | 29473001 |
Febrile neutropenia | 128.66 | 11.16 | 48 | 67629 | 112192 | 29394658 |
Pyrexia | 125.82 | 11.16 | 297 | 67380 | 287325 | 29219525 |
Fatigue | 105.97 | 11.16 | 1148 | 66529 | 315673 | 29191177 |
Anger | 104.82 | 11.16 | 127 | 67550 | 10763 | 29496087 |
Thrombocytopenia | 101.96 | 11.16 | 95 | 67582 | 134728 | 29372122 |
Withdrawal syndrome | 95.86 | 11.16 | 122 | 67555 | 10870 | 29495980 |
Acute kidney injury | 94.18 | 11.16 | 303 | 67374 | 264964 | 29241886 |
Gastrointestinal tube insertion | 89.05 | 11.16 | 46 | 67631 | 1083 | 29505767 |
Anaemia | 88.90 | 11.16 | 206 | 67471 | 200745 | 29306105 |
Depression | 82.14 | 11.16 | 399 | 67278 | 84748 | 29422102 |
Neutropenia | 76.83 | 11.16 | 114 | 67563 | 131597 | 29375253 |
Somnolence | 75.88 | 11.16 | 419 | 67258 | 93536 | 29413314 |
Intentional self-injury | 72.55 | 11.16 | 114 | 67563 | 12347 | 29494503 |
Pancytopenia | 69.70 | 11.16 | 53 | 67624 | 83115 | 29423735 |
Feeling abnormal | 68.28 | 11.16 | 276 | 67401 | 54169 | 29452681 |
Fall | 65.08 | 11.16 | 655 | 67022 | 176523 | 29330327 |
Memory impairment | 61.90 | 11.16 | 204 | 67473 | 36266 | 29470584 |
Disturbance in attention | 60.25 | 11.16 | 144 | 67533 | 21280 | 29485570 |
Dyspnoea | 58.20 | 11.16 | 474 | 67203 | 326258 | 29180592 |
Sepsis | 57.75 | 11.16 | 153 | 67524 | 142529 | 29364321 |
Disease progression | 56.97 | 11.16 | 62 | 67615 | 81854 | 29424996 |
Multiple organ dysfunction syndrome | 54.45 | 11.16 | 39 | 67638 | 63077 | 29443773 |
Hepatic enzyme increased | 52.90 | 11.16 | 184 | 67493 | 33615 | 29473235 |
Platelet count decreased | 51.45 | 11.16 | 101 | 67576 | 104571 | 29402279 |
Pleural effusion | 50.47 | 11.16 | 54 | 67623 | 71854 | 29434996 |
Sexual dysfunction | 49.85 | 11.16 | 64 | 67613 | 5750 | 29501100 |
Mucosal inflammation | 48.99 | 11.16 | 7 | 67670 | 31588 | 29475262 |
Haemoglobin decreased | 47.91 | 11.16 | 111 | 67566 | 108264 | 29398586 |
Loss of consciousness | 47.44 | 11.16 | 311 | 67366 | 73745 | 29433105 |
Malignant neoplasm progression | 46.97 | 11.16 | 60 | 67617 | 73799 | 29433051 |
Sedation | 45.75 | 11.16 | 114 | 67563 | 17291 | 29489559 |
Intentional overdose | 45.68 | 11.16 | 192 | 67485 | 38336 | 29468514 |
Respiratory disorder neonatal | 44.35 | 11.16 | 32 | 67645 | 1393 | 29505457 |
Renal failure | 42.97 | 11.16 | 134 | 67543 | 118465 | 29388385 |
Blood creatinine increased | 42.78 | 11.16 | 81 | 67596 | 85021 | 29421829 |
Leukopenia | 42.73 | 11.16 | 38 | 67639 | 55165 | 29451685 |
Myoclonus | 41.30 | 11.16 | 93 | 67584 | 13216 | 29493634 |
Migraine | 40.99 | 11.16 | 89 | 67588 | 12341 | 29494509 |
Respiratory failure | 39.39 | 11.16 | 104 | 67573 | 97027 | 29409823 |
Antidepressant drug level above therapeutic | 39.26 | 11.16 | 15 | 67662 | 166 | 29506684 |
Product use in unapproved indication | 39.18 | 11.16 | 88 | 67589 | 86787 | 29420063 |
Toxicity to various agents | 37.32 | 11.16 | 581 | 67096 | 173080 | 29333770 |
Therapy interrupted | 37.24 | 11.16 | 68 | 67609 | 8318 | 29498532 |
Urinary retention | 37.06 | 11.16 | 158 | 67519 | 31740 | 29475110 |
Gastric bypass | 36.92 | 11.16 | 16 | 67661 | 250 | 29506600 |
Cardiac failure | 36.83 | 11.16 | 79 | 67598 | 79208 | 29427642 |
General physical health deterioration | 36.69 | 11.16 | 117 | 67560 | 102740 | 29404110 |
Ascites | 36.63 | 11.16 | 19 | 67658 | 36600 | 29470250 |
Road traffic accident | 34.84 | 11.16 | 96 | 67581 | 15465 | 29491385 |
Pneumonia | 34.72 | 11.16 | 520 | 67157 | 319652 | 29187198 |
Analgesic drug level above therapeutic | 34.12 | 11.16 | 15 | 67662 | 243 | 29506607 |
Urinary hesitation | 33.92 | 11.16 | 33 | 67644 | 2180 | 29504670 |
Haemorrhage | 33.73 | 11.16 | 32 | 67645 | 45040 | 29461810 |
Balance disorder | 33.05 | 11.16 | 167 | 67510 | 36003 | 29470847 |
Drug resistance | 32.86 | 11.16 | 5 | 67672 | 21535 | 29485315 |
Cytomegalovirus infection | 31.95 | 11.16 | 7 | 67670 | 23208 | 29483642 |
Abnormal dreams | 31.85 | 11.16 | 57 | 67620 | 6863 | 29499987 |
Aggression | 31.70 | 11.16 | 163 | 67514 | 35378 | 29471472 |
Septic shock | 31.03 | 11.16 | 60 | 67617 | 62500 | 29444350 |
Mania | 30.85 | 11.16 | 64 | 67613 | 8599 | 29498251 |
C-reactive protein increased | 30.21 | 11.16 | 34 | 67643 | 44229 | 29462621 |
Pain | 29.70 | 11.16 | 554 | 67123 | 170878 | 29335972 |
Metabolic acidosis | 29.05 | 11.16 | 26 | 67651 | 37636 | 29469214 |
Disorientation | 28.90 | 11.16 | 139 | 67538 | 29376 | 29477474 |
Hallucination | 28.14 | 11.16 | 187 | 67490 | 44525 | 29462325 |
Overdose | 27.74 | 11.16 | 292 | 67385 | 79527 | 29427323 |
Amnesia | 27.73 | 11.16 | 114 | 67563 | 22529 | 29484321 |
Surgery | 27.71 | 11.16 | 74 | 67603 | 11705 | 29495145 |
Yawning | 27.65 | 11.16 | 16 | 67661 | 474 | 29506376 |
Dehydration | 27.58 | 11.16 | 152 | 67525 | 114596 | 29392254 |
Self esteem decreased | 26.86 | 11.16 | 16 | 67661 | 501 | 29506349 |
Hypokalaemia | 26.82 | 11.16 | 46 | 67631 | 50157 | 29456693 |
Cough | 26.20 | 11.16 | 176 | 67501 | 126551 | 29380299 |
Disseminated intravascular coagulation | 25.60 | 11.16 | 7 | 67670 | 19973 | 29486877 |
Bone marrow failure | 24.95 | 11.16 | 16 | 67661 | 27433 | 29479417 |
Atrial fibrillation | 24.81 | 11.16 | 141 | 67536 | 105505 | 29401345 |
Renal impairment | 24.68 | 11.16 | 99 | 67578 | 81234 | 29425616 |
Initial insomnia | 24.51 | 11.16 | 31 | 67646 | 2744 | 29504106 |
Agranulocytosis | 24.47 | 11.16 | 8 | 67669 | 20332 | 29486518 |
Toxic epidermal necrolysis | 23.94 | 11.16 | 6 | 67671 | 18147 | 29488703 |
White blood cell count decreased | 23.73 | 11.16 | 104 | 67573 | 83258 | 29423592 |
Feeling jittery | 23.63 | 11.16 | 35 | 67642 | 3598 | 29503252 |
Hallucination, auditory | 23.31 | 11.16 | 61 | 67616 | 9532 | 29497318 |
Abnormal behaviour | 22.70 | 11.16 | 109 | 67568 | 23018 | 29483832 |
International normalised ratio increased | 22.49 | 11.16 | 42 | 67635 | 44330 | 29462520 |
Post concussion syndrome | 22.47 | 11.16 | 9 | 67668 | 114 | 29506736 |
Drug hypersensitivity | 22.25 | 11.16 | 247 | 67430 | 68159 | 29438691 |
Convulsive threshold lowered | 22.13 | 11.16 | 14 | 67663 | 489 | 29506361 |
Homicidal ideation | 21.98 | 11.16 | 28 | 67649 | 2496 | 29504354 |
Infusion related reaction | 21.84 | 11.16 | 42 | 67635 | 43844 | 29463006 |
Erectile dysfunction | 21.53 | 11.16 | 90 | 67587 | 17919 | 29488931 |
Muscle spasticity | 20.93 | 11.16 | 39 | 67638 | 4844 | 29502006 |
Acute stress disorder | 20.92 | 11.16 | 9 | 67668 | 138 | 29506712 |
Dystonia | 20.70 | 11.16 | 59 | 67618 | 9690 | 29497160 |
Agitation neonatal | 20.56 | 11.16 | 18 | 67659 | 1038 | 29505812 |
Respiratory distress | 20.48 | 11.16 | 26 | 67651 | 32080 | 29474770 |
Interstitial lung disease | 20.32 | 11.16 | 66 | 67611 | 57652 | 29449198 |
Hypotension | 20.19 | 11.16 | 318 | 67359 | 194036 | 29312814 |
Clonus | 20.11 | 11.16 | 26 | 67651 | 2352 | 29504498 |
Growth hormone deficiency | 19.97 | 11.16 | 10 | 67667 | 220 | 29506630 |
Complex regional pain syndrome | 19.95 | 11.16 | 13 | 67664 | 478 | 29506372 |
Bradyphrenia | 19.77 | 11.16 | 35 | 67642 | 4179 | 29502671 |
Somnambulism | 19.72 | 11.16 | 28 | 67649 | 2770 | 29504080 |
Haematuria | 19.65 | 11.16 | 45 | 67632 | 44094 | 29462756 |
Myocardial infarction | 19.53 | 11.16 | 160 | 67517 | 110136 | 29396714 |
Neuralgia | 19.50 | 11.16 | 62 | 67615 | 10812 | 29496038 |
Electric shock sensation | 19.49 | 11.16 | 6 | 67671 | 32 | 29506818 |
Major depression | 19.49 | 11.16 | 33 | 67644 | 3802 | 29503048 |
Pneumocystis jirovecii pneumonia | 19.49 | 11.16 | 7 | 67670 | 16772 | 29490078 |
Intentional product misuse | 19.46 | 11.16 | 141 | 67536 | 34520 | 29472330 |
Delirium | 19.18 | 11.16 | 155 | 67522 | 39242 | 29467608 |
Acute myeloid leukaemia | 18.99 | 11.16 | 7 | 67670 | 16506 | 29490344 |
Off label use | 18.94 | 11.16 | 534 | 67143 | 300266 | 29206584 |
Hypocalcaemia | 18.84 | 11.16 | 12 | 67665 | 20653 | 29486197 |
Pneumonitis | 18.64 | 11.16 | 22 | 67655 | 28022 | 29478828 |
Cardiac failure congestive | 18.63 | 11.16 | 101 | 67576 | 76480 | 29430370 |
Multiple sclerosis relapse | 18.58 | 11.16 | 63 | 67614 | 11356 | 29495494 |
Wrong drug | 18.28 | 11.16 | 7 | 67670 | 78 | 29506772 |
Haemoptysis | 18.21 | 11.16 | 26 | 67651 | 30524 | 29476326 |
Dysmetropsia | 18.10 | 11.16 | 4 | 67673 | 3 | 29506847 |
Sleep-related eating disorder | 17.92 | 11.16 | 10 | 67667 | 276 | 29506574 |
Therapy cessation | 17.86 | 11.16 | 73 | 67604 | 14389 | 29492461 |
Neuropathy peripheral | 17.72 | 11.16 | 244 | 67433 | 70783 | 29436067 |
Liver function test abnormal | 17.62 | 11.16 | 120 | 67557 | 28798 | 29478052 |
Sleep sex | 17.57 | 11.16 | 4 | 67673 | 4 | 29506846 |
Oedema peripheral | 17.53 | 11.16 | 152 | 67525 | 103405 | 29403445 |
Compulsive shopping | 17.42 | 11.16 | 11 | 67666 | 383 | 29506467 |
Neutrophil count decreased | 17.37 | 11.16 | 47 | 67630 | 43520 | 29463330 |
Affective disorder | 17.37 | 11.16 | 28 | 67649 | 3098 | 29503752 |
Acute myocardial infarction | 17.32 | 11.16 | 55 | 67622 | 48383 | 29458467 |
Rash maculo-papular | 17.30 | 11.16 | 18 | 67659 | 24271 | 29482579 |
Steatohepatitis | 17.29 | 11.16 | 10 | 67667 | 296 | 29506554 |
Productive cough | 17.28 | 11.16 | 28 | 67649 | 31231 | 29475619 |
Angioedema | 17.26 | 11.16 | 29 | 67648 | 31886 | 29474964 |
Hypersomnia | 17.21 | 11.16 | 59 | 67618 | 10695 | 29496155 |
Pericardial effusion | 17.14 | 11.16 | 14 | 67663 | 21194 | 29485656 |
Prescribed overdose | 16.95 | 11.16 | 51 | 67626 | 8632 | 29498218 |
Feeling guilty | 16.88 | 11.16 | 10 | 67667 | 310 | 29506540 |
Lymphopenia | 16.86 | 11.16 | 5 | 67672 | 13528 | 29493322 |
Gastrointestinal haemorrhage | 16.65 | 11.16 | 110 | 67567 | 79423 | 29427427 |
Erythema | 16.63 | 11.16 | 103 | 67574 | 75503 | 29431347 |
Fibromyalgia | 16.63 | 11.16 | 25 | 67652 | 2604 | 29504246 |
Tardive dyskinesia | 16.60 | 11.16 | 37 | 67640 | 5221 | 29501629 |
Delirium tremens | 16.60 | 11.16 | 12 | 67665 | 524 | 29506326 |
Forced expiratory flow decreased | 16.58 | 11.16 | 8 | 67669 | 162 | 29506688 |
Restless legs syndrome | 16.55 | 11.16 | 44 | 67633 | 6940 | 29499910 |
Psychotic disorder | 16.54 | 11.16 | 91 | 67586 | 20263 | 29486587 |
Drug reaction with eosinophilia and systemic symptoms | 16.51 | 11.16 | 24 | 67653 | 27968 | 29478882 |
Neonatal tachypnoea | 16.45 | 11.16 | 8 | 67669 | 165 | 29506685 |
Rash | 16.38 | 11.16 | 321 | 67356 | 189498 | 29317352 |
Gait disturbance | 16.32 | 11.16 | 247 | 67430 | 73102 | 29433748 |
Paedophilia | 16.30 | 11.16 | 4 | 67673 | 7 | 29506843 |
Dry mouth | 16.13 | 11.16 | 95 | 67582 | 21689 | 29485161 |
Drug tolerance | 15.85 | 11.16 | 22 | 67655 | 2131 | 29504719 |
Apathy | 15.77 | 11.16 | 40 | 67637 | 6131 | 29500719 |
Depressed mood | 15.76 | 11.16 | 77 | 67600 | 16371 | 29490479 |
Bradycardia | 15.72 | 11.16 | 87 | 67590 | 65542 | 29441308 |
Depression suicidal | 15.45 | 11.16 | 17 | 67660 | 1298 | 29505552 |
Seizure | 15.42 | 11.16 | 299 | 67378 | 92824 | 29414026 |
Neoplasm progression | 15.40 | 11.16 | 12 | 67665 | 18600 | 29488250 |
Ventricular hypoplasia | 15.34 | 11.16 | 6 | 67671 | 71 | 29506779 |
Nephropathy toxic | 15.30 | 11.16 | 3 | 67674 | 10753 | 29496097 |
Hyperlipasaemia | 15.30 | 11.16 | 11 | 67666 | 476 | 29506374 |
Orgasm abnormal | 15.25 | 11.16 | 7 | 67670 | 126 | 29506724 |
Coronary artery disease | 15.23 | 11.16 | 51 | 67626 | 44139 | 29462711 |
Neonatal hyponatraemia | 15.19 | 11.16 | 6 | 67671 | 73 | 29506777 |
Blood lactate dehydrogenase increased | 15.13 | 11.16 | 13 | 67664 | 19196 | 29487654 |
Cardiogenic shock | 15.10 | 11.16 | 13 | 67664 | 19177 | 29487673 |
Mental disorder | 15.04 | 11.16 | 64 | 67613 | 12841 | 29494009 |
Epistaxis | 15.01 | 11.16 | 64 | 67613 | 51640 | 29455210 |
Alcoholism | 15.01 | 11.16 | 24 | 67653 | 2637 | 29504213 |
Bipolar disorder | 14.98 | 11.16 | 27 | 67650 | 3268 | 29503582 |
Cerebral infarction | 14.70 | 11.16 | 21 | 67656 | 24654 | 29482196 |
Drug screen positive | 14.62 | 11.16 | 29 | 67648 | 3772 | 29503078 |
Urethral discharge | 14.57 | 11.16 | 4 | 67673 | 13 | 29506837 |
Narcissistic personality disorder | 14.57 | 11.16 | 4 | 67673 | 13 | 29506837 |
Thinking abnormal | 14.50 | 11.16 | 35 | 67642 | 5201 | 29501649 |
Pulmonary embolism | 14.48 | 11.16 | 109 | 67568 | 76425 | 29430425 |
Libido decreased | 14.43 | 11.16 | 31 | 67646 | 4267 | 29502583 |
Stiff person syndrome | 14.37 | 11.16 | 6 | 67671 | 85 | 29506765 |
Cytokine release syndrome | 14.36 | 11.16 | 6 | 67671 | 13113 | 29493737 |
Pulmonary fibrosis | 14.27 | 11.16 | 9 | 67668 | 15573 | 29491277 |
Palmar-plantar erythrodysaesthesia syndrome | 14.26 | 11.16 | 8 | 67669 | 14751 | 29492099 |
Chills | 14.23 | 11.16 | 100 | 67577 | 71200 | 29435650 |
Tumour lysis syndrome | 14.19 | 11.16 | 7 | 67670 | 13877 | 29492973 |
Axillary pain | 14.18 | 11.16 | 9 | 67668 | 316 | 29506534 |
Retrograde ejaculation | 14.16 | 11.16 | 9 | 67668 | 317 | 29506533 |
Stomatitis | 14.09 | 11.16 | 41 | 67636 | 37072 | 29469778 |
Anaphylactic reaction | 14.06 | 11.16 | 26 | 67651 | 27547 | 29479303 |
Speech sound disorder | 13.98 | 11.16 | 7 | 67670 | 154 | 29506696 |
Cholestasis | 13.95 | 11.16 | 20 | 67657 | 23442 | 29483408 |
Paranoia | 13.94 | 11.16 | 52 | 67625 | 9825 | 29497025 |
Haematochezia | 13.93 | 11.16 | 41 | 67636 | 36942 | 29469908 |
Dyskinesia | 13.90 | 11.16 | 86 | 67591 | 19975 | 29486875 |
Treatment failure | 13.88 | 11.16 | 41 | 67636 | 36898 | 29469952 |
Tubulointerstitial nephritis | 13.82 | 11.16 | 12 | 67665 | 17631 | 29489219 |
Rhabdomyolysis | 13.81 | 11.16 | 82 | 67595 | 60726 | 29446124 |
Restlessness | 13.55 | 11.16 | 92 | 67585 | 22053 | 29484797 |
Angina pectoris | 13.55 | 11.16 | 27 | 67650 | 27823 | 29479027 |
Tethered cord syndrome | 13.55 | 11.16 | 4 | 67673 | 18 | 29506832 |
Hypoxia | 13.54 | 11.16 | 59 | 67618 | 47320 | 29459530 |
Influenza like illness | 13.42 | 11.16 | 99 | 67578 | 24371 | 29482479 |
Lymphadenopathy | 13.33 | 11.16 | 23 | 67654 | 25026 | 29481824 |
Suicidal behaviour | 13.26 | 11.16 | 16 | 67661 | 1349 | 29505501 |
Undifferentiated connective tissue disease | 13.21 | 11.16 | 4 | 67673 | 20 | 29506830 |
Psychopathic personality | 13.17 | 11.16 | 3 | 67674 | 3 | 29506847 |
Facial spasm | 13.10 | 11.16 | 7 | 67670 | 177 | 29506673 |
Loss of employment | 13.06 | 11.16 | 10 | 67667 | 477 | 29506373 |
Blood urea increased | 13.05 | 11.16 | 28 | 67649 | 28084 | 29478766 |
Ureteric haemorrhage | 12.97 | 11.16 | 6 | 67671 | 110 | 29506740 |
Melaena | 12.91 | 11.16 | 33 | 67644 | 31143 | 29475707 |
Muscle twitching | 12.81 | 11.16 | 44 | 67633 | 7982 | 29498868 |
Homicide | 12.68 | 11.16 | 13 | 67664 | 915 | 29505935 |
Brief psychotic disorder with marked stressors | 12.65 | 11.16 | 7 | 67670 | 190 | 29506660 |
Chest injury | 12.64 | 11.16 | 16 | 67661 | 1417 | 29505433 |
Concussion | 12.30 | 11.16 | 19 | 67658 | 2027 | 29504823 |
Ileus | 12.28 | 11.16 | 9 | 67668 | 14393 | 29492457 |
Acute respiratory distress syndrome | 12.26 | 11.16 | 21 | 67656 | 22914 | 29483936 |
Disease recurrence | 12.25 | 11.16 | 11 | 67666 | 15903 | 29490947 |
Selective eating disorder | 12.25 | 11.16 | 17 | 67660 | 1646 | 29505204 |
Psychomotor hyperactivity | 12.23 | 11.16 | 44 | 67633 | 8169 | 29498681 |
Hyperglycaemia | 12.21 | 11.16 | 39 | 67638 | 34248 | 29472602 |
Autonomic dysreflexia | 12.10 | 11.16 | 5 | 67672 | 69 | 29506781 |
Drug screen false positive | 12.07 | 11.16 | 11 | 67666 | 669 | 29506181 |
Helplessness | 12.03 | 11.16 | 5 | 67672 | 70 | 29506780 |
Central nervous system stimulation | 11.97 | 11.16 | 3 | 67674 | 6 | 29506844 |
Lung disorder | 11.92 | 11.16 | 33 | 67644 | 30329 | 29476521 |
Abdominal compartment syndrome | 11.91 | 11.16 | 12 | 67665 | 827 | 29506023 |
Pseudomonas infection | 11.82 | 11.16 | 5 | 67672 | 10847 | 29496003 |
Product prescribing error | 11.80 | 11.16 | 76 | 67601 | 17900 | 29488950 |
Myelodysplastic syndrome | 11.78 | 11.16 | 14 | 67663 | 17780 | 29489070 |
Posterior reversible encephalopathy syndrome | 11.77 | 11.16 | 3 | 67674 | 8973 | 29497877 |
Peritonitis | 11.71 | 11.16 | 10 | 67667 | 14814 | 29492036 |
Hyperreflexia | 11.71 | 11.16 | 22 | 67655 | 2750 | 29504100 |
Blue toe syndrome | 11.70 | 11.16 | 6 | 67671 | 139 | 29506711 |
Deep vein thrombosis | 11.70 | 11.16 | 80 | 67597 | 57319 | 29449531 |
Mood altered | 11.69 | 11.16 | 43 | 67634 | 8068 | 29498782 |
Panic disorder | 11.65 | 11.16 | 14 | 67663 | 1176 | 29505674 |
Snoring | 11.64 | 11.16 | 22 | 67655 | 2762 | 29504088 |
Hepatitis E antibody positive | 11.62 | 11.16 | 6 | 67671 | 141 | 29506709 |
Lymphoma | 11.59 | 11.16 | 4 | 67673 | 9824 | 29497026 |
Gout | 11.52 | 11.16 | 13 | 67664 | 16898 | 29489952 |
Reflexes abnormal | 11.51 | 11.16 | 8 | 67669 | 328 | 29506522 |
Abdominal pain | 11.33 | 11.16 | 230 | 67447 | 135127 | 29371723 |
Graft versus host disease | 11.21 | 11.16 | 4 | 67673 | 9624 | 29497226 |
Multiple sclerosis | 11.20 | 11.16 | 33 | 67644 | 5521 | 29501329 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 974.97 | 9.84 | 782 | 191569 | 30509 | 64275872 |
Suicidal ideation | 762.82 | 9.84 | 966 | 191385 | 65576 | 64240805 |
Serotonin syndrome | 672.96 | 9.84 | 702 | 191649 | 38580 | 64267801 |
Completed suicide | 486.39 | 9.84 | 1623 | 190728 | 222791 | 64083590 |
Dysphoria | 477.23 | 9.84 | 242 | 192109 | 4146 | 64302235 |
Hyperhidrosis | 439.10 | 9.84 | 1076 | 191275 | 123844 | 64182537 |
Affect lability | 380.57 | 9.84 | 270 | 192081 | 8720 | 64297661 |
Irritability | 367.42 | 9.84 | 499 | 191852 | 36247 | 64270134 |
Anxiety | 333.57 | 9.84 | 1341 | 191010 | 201308 | 64105073 |
Tremor | 302.25 | 9.84 | 1051 | 191300 | 147179 | 64159202 |
Nightmare | 293.05 | 9.84 | 337 | 192014 | 20656 | 64285725 |
Insomnia | 283.39 | 9.84 | 1255 | 191096 | 196581 | 64109800 |
Febrile neutropenia | 277.81 | 9.84 | 106 | 192245 | 187551 | 64118830 |
Agitation | 267.73 | 9.84 | 720 | 191631 | 87647 | 64218734 |
Dizziness | 241.93 | 9.84 | 2144 | 190207 | 428019 | 63878362 |
Depression | 222.31 | 9.84 | 1108 | 191243 | 182183 | 64124198 |
Thrombocytopenia | 221 | 9.84 | 205 | 192146 | 223596 | 64082785 |
Paraesthesia | 220.97 | 9.84 | 890 | 191461 | 133632 | 64172749 |
Suicide attempt | 220.56 | 9.84 | 584 | 191767 | 70423 | 64235958 |
Neutropenia | 217.75 | 9.84 | 236 | 192115 | 239388 | 64066993 |
Somnolence | 212.62 | 9.84 | 1181 | 191170 | 202464 | 64103917 |
Feeling abnormal | 203.76 | 9.84 | 864 | 191487 | 132738 | 64173643 |
Pyrexia | 203.56 | 9.84 | 916 | 191435 | 557728 | 63748653 |
Vertigo | 201.51 | 9.84 | 503 | 191848 | 58508 | 64247873 |
Withdrawal syndrome | 197.86 | 9.84 | 294 | 192057 | 23198 | 64283183 |
Mood swings | 192.73 | 9.84 | 249 | 192102 | 17219 | 64289162 |
Stubbornness | 191.11 | 9.84 | 60 | 192291 | 251 | 64306130 |
Sensory disturbance | 191.06 | 9.84 | 216 | 192135 | 12992 | 64293389 |
Anaemia | 182.34 | 9.84 | 553 | 191798 | 378127 | 63928254 |
Acute kidney injury | 175.52 | 9.84 | 717 | 191634 | 448523 | 63857858 |
Fall | 168.74 | 9.84 | 1942 | 190409 | 414884 | 63891497 |
Pancytopenia | 168.35 | 9.84 | 110 | 192241 | 143199 | 64163182 |
Pemphigus | 161.86 | 9.84 | 4 | 192347 | 60697 | 64245684 |
Fibromyalgia | 148.59 | 9.84 | 329 | 192022 | 35402 | 64270979 |
Headache | 148.49 | 9.84 | 2308 | 190043 | 527159 | 63779222 |
Crying | 144.80 | 9.84 | 234 | 192117 | 19856 | 64286525 |
Mood altered | 144.75 | 9.84 | 207 | 192144 | 15772 | 64290609 |
Migraine | 141.37 | 9.84 | 460 | 191891 | 62217 | 64244164 |
Nausea | 138.81 | 9.84 | 3189 | 189162 | 782611 | 63523770 |
Intentional self-injury | 134.07 | 9.84 | 279 | 192072 | 28765 | 64277616 |
Memory impairment | 129.69 | 9.84 | 553 | 191798 | 85129 | 64221252 |
Anger | 128.27 | 9.84 | 194 | 192157 | 15547 | 64290834 |
Disturbance in attention | 122.64 | 9.84 | 333 | 192018 | 40741 | 64265640 |
Confusional state | 122.24 | 9.84 | 1253 | 191098 | 259891 | 64046490 |
Tinnitus | 120.78 | 9.84 | 295 | 192056 | 33838 | 64272543 |
Platelet count decreased | 116.15 | 9.84 | 201 | 192150 | 167510 | 64138871 |
Thinking abnormal | 115.57 | 9.84 | 157 | 192194 | 11399 | 64294982 |
Pericarditis | 111.28 | 9.84 | 25 | 192326 | 62491 | 64243890 |
Malignant neoplasm progression | 110.60 | 9.84 | 104 | 192247 | 112767 | 64193614 |
Sepsis | 106.72 | 9.84 | 342 | 192009 | 229999 | 64076382 |
Loss of consciousness | 102.15 | 9.84 | 775 | 191576 | 147590 | 64158791 |
Therapy interrupted | 100.22 | 9.84 | 199 | 192152 | 19837 | 64286544 |
Cardiac failure | 99.78 | 9.84 | 150 | 192201 | 132223 | 64174158 |
Depressed mood | 97.93 | 9.84 | 307 | 192044 | 40705 | 64265676 |
Synovitis | 95.10 | 9.84 | 93 | 192258 | 98997 | 64207384 |
Glossodynia | 94.90 | 9.84 | 37 | 192314 | 64659 | 64241722 |
Hypomania | 94.89 | 9.84 | 100 | 192251 | 5554 | 64300827 |
Electric shock | 93.71 | 9.84 | 52 | 192299 | 1077 | 64305304 |
Product substitution issue | 93.71 | 9.84 | 181 | 192170 | 17680 | 64288701 |
Hand deformity | 93.57 | 9.84 | 35 | 192316 | 62736 | 64243645 |
Septic shock | 93.29 | 9.84 | 106 | 192245 | 105331 | 64201050 |
Inappropriate antidiuretic hormone secretion | 92.40 | 9.84 | 205 | 192146 | 22084 | 64284297 |
Disease progression | 91.67 | 9.84 | 177 | 192174 | 141503 | 64164878 |
Affective disorder | 90.75 | 9.84 | 105 | 192246 | 6475 | 64299906 |
Mucosal inflammation | 89.82 | 9.84 | 37 | 192314 | 62547 | 64243834 |
Renal failure | 87.50 | 9.84 | 265 | 192086 | 181423 | 64124958 |
Multiple sclerosis relapse | 85.72 | 9.84 | 294 | 192057 | 40841 | 64265540 |
Contraindicated product administered | 84.38 | 9.84 | 119 | 192232 | 107710 | 64198671 |
Duodenal ulcer perforation | 83.15 | 9.84 | 5 | 192346 | 34620 | 64271761 |
Drug hypersensitivity | 82.93 | 9.84 | 1078 | 191273 | 236737 | 64069644 |
Multiple organ dysfunction syndrome | 82.30 | 9.84 | 109 | 192242 | 101304 | 64205077 |
Restless legs syndrome | 82.03 | 9.84 | 167 | 192184 | 16949 | 64289432 |
Blood creatinine increased | 81.59 | 9.84 | 177 | 192174 | 135605 | 64170776 |
Pain | 80.29 | 9.84 | 2189 | 190162 | 551322 | 63755059 |
Ascites | 79.23 | 9.84 | 43 | 192308 | 61958 | 64244423 |
Abnormal behaviour | 78.73 | 9.84 | 250 | 192101 | 33372 | 64273009 |
Dry mouth | 78.68 | 9.84 | 373 | 191978 | 60045 | 64246336 |
Somatic symptom disorder | 76.52 | 9.84 | 55 | 192296 | 1813 | 64304568 |
General physical health deterioration | 76.08 | 9.84 | 332 | 192019 | 204093 | 64102288 |
Leukopenia | 76.02 | 9.84 | 115 | 192236 | 101127 | 64205254 |
Drug reaction with eosinophilia and systemic symptoms | 74.71 | 9.84 | 34 | 192317 | 54183 | 64252198 |
Weight increased | 73.91 | 9.84 | 966 | 191385 | 212382 | 64093999 |
Multiple sclerosis | 72.73 | 9.84 | 169 | 192182 | 18772 | 64287609 |
Toxicity to various agents | 72.62 | 9.84 | 1503 | 190848 | 362010 | 63944371 |
Tardive dyskinesia | 70.40 | 9.84 | 110 | 192241 | 9068 | 64297313 |
Amnesia | 70.30 | 9.84 | 308 | 192043 | 47961 | 64258420 |
Pleural effusion | 69.58 | 9.84 | 173 | 192178 | 126386 | 64179995 |
Renal impairment | 68.58 | 9.84 | 192 | 192159 | 134825 | 64171556 |
Post-traumatic stress disorder | 68.14 | 9.84 | 73 | 192278 | 4132 | 64302249 |
Therapy cessation | 67.51 | 9.84 | 232 | 192119 | 32257 | 64274124 |
C-reactive protein abnormal | 67.38 | 9.84 | 5 | 192346 | 29042 | 64277339 |
Coordination abnormal | 67.02 | 9.84 | 142 | 192209 | 14822 | 64291559 |
Bone marrow failure | 66.19 | 9.84 | 30 | 192321 | 47922 | 64258459 |
Cytomegalovirus infection | 65.95 | 9.84 | 15 | 192336 | 37184 | 64269197 |
Mania | 65.50 | 9.84 | 148 | 192203 | 16138 | 64290243 |
Surgery | 65.34 | 9.84 | 209 | 192142 | 28004 | 64278377 |
Sopor | 65.34 | 9.84 | 216 | 192135 | 29445 | 64276936 |
Drug interaction | 65.23 | 9.84 | 1475 | 190876 | 360608 | 63945773 |
Off label use | 64.73 | 9.84 | 1417 | 190934 | 631389 | 63674992 |
Balance disorder | 63.21 | 9.84 | 448 | 191903 | 83478 | 64222903 |
Infusion related reaction | 63.08 | 9.84 | 264 | 192087 | 164203 | 64142178 |
Dyspnoea | 62.87 | 9.84 | 1648 | 190703 | 717026 | 63589355 |
Panic attack | 62.66 | 9.84 | 170 | 192181 | 20783 | 64285598 |
Urinary retention | 62.07 | 9.84 | 301 | 192050 | 48900 | 64257481 |
Pneumonia | 61.61 | 9.84 | 1238 | 191113 | 558338 | 63748043 |
Sleep disorder | 61.32 | 9.84 | 345 | 192006 | 59364 | 64247017 |
Haemoglobin decreased | 60.91 | 9.84 | 337 | 192014 | 194726 | 64111655 |
Neutrophil count decreased | 60.58 | 9.84 | 85 | 192266 | 77111 | 64229270 |
Maternal exposure during pregnancy | 60.10 | 9.84 | 122 | 192229 | 95762 | 64210619 |
Gastric bypass | 59.99 | 9.84 | 38 | 192313 | 1012 | 64305369 |
Atrial fibrillation | 59.97 | 9.84 | 284 | 192067 | 170805 | 64135576 |
Sleep disorder due to general medical condition, insomnia type | 59.60 | 9.84 | 5 | 192346 | 26265 | 64280116 |
Systemic lupus erythematosus | 59.38 | 9.84 | 87 | 192264 | 77525 | 64228856 |
Pneumonia aspiration | 58.59 | 9.84 | 339 | 192012 | 58932 | 64247449 |
Neck deformity | 58.04 | 9.84 | 45 | 192306 | 1667 | 64304714 |
Coma blister | 57.90 | 9.84 | 23 | 192328 | 213 | 64306168 |
Folliculitis | 57.78 | 9.84 | 10 | 192341 | 30067 | 64276314 |
Nasal turbinate hypertrophy | 57.57 | 9.84 | 30 | 192321 | 545 | 64305836 |
Hallucination | 57.43 | 9.84 | 393 | 191958 | 72395 | 64233986 |
Gastrointestinal tube insertion | 57.19 | 9.84 | 42 | 192309 | 1432 | 64304949 |
Abnormal dreams | 56.86 | 9.84 | 107 | 192244 | 10249 | 64296132 |
Coma | 56.56 | 9.84 | 451 | 191900 | 87164 | 64219217 |
Intentional overdose | 55.90 | 9.84 | 459 | 191892 | 89485 | 64216896 |
Fatigue | 54.96 | 9.84 | 2743 | 189608 | 745987 | 63560394 |
Lethargy | 54.95 | 9.84 | 388 | 191963 | 72206 | 64234175 |
Hypocalcaemia | 54.76 | 9.84 | 28 | 192323 | 41725 | 64264656 |
Rubber sensitivity | 54.06 | 9.84 | 39 | 192312 | 1293 | 64305088 |
Prescribed overdose | 53.99 | 9.84 | 158 | 192193 | 20173 | 64286208 |
Disorientation | 53.04 | 9.84 | 316 | 192035 | 55512 | 64250869 |
Treatment failure | 52.97 | 9.84 | 175 | 192176 | 116641 | 64189740 |
Interstitial lung disease | 52.62 | 9.84 | 135 | 192216 | 97597 | 64208784 |
Hyperreflexia | 52.52 | 9.84 | 84 | 192267 | 7064 | 64299317 |
Stiff person syndrome | 52.21 | 9.84 | 22 | 192329 | 240 | 64306141 |
Rash | 51.77 | 9.84 | 1010 | 191341 | 457539 | 63848842 |
Alopecia | 50.77 | 9.84 | 288 | 192063 | 165402 | 64140979 |
Respiratory failure | 50.56 | 9.84 | 278 | 192073 | 160905 | 64145476 |
Hypersensitivity | 50.20 | 9.84 | 361 | 191990 | 196091 | 64110290 |
Bronchial neoplasm | 49.83 | 9.84 | 25 | 192326 | 418 | 64305963 |
Erythema | 49.64 | 9.84 | 340 | 192011 | 186730 | 64119651 |
Product dose omission issue | 49.47 | 9.84 | 836 | 191515 | 193911 | 64112470 |
Extremity contracture | 49.28 | 9.84 | 40 | 192311 | 1585 | 64304796 |
Mental disorder | 49.09 | 9.84 | 182 | 192169 | 26263 | 64280118 |
Hallucination, visual | 48.73 | 9.84 | 188 | 192163 | 27646 | 64278735 |
Drug resistance | 48.38 | 9.84 | 22 | 192329 | 35080 | 64271301 |
Clonus | 48.33 | 9.84 | 74 | 192277 | 5993 | 64300388 |
Psoriasis | 47.87 | 9.84 | 372 | 191979 | 71331 | 64235050 |
Product use in unapproved indication | 47.86 | 9.84 | 319 | 192032 | 176299 | 64130082 |
Intentional product misuse | 47.68 | 9.84 | 374 | 191977 | 71921 | 64234460 |
Colitis microscopic | 47.45 | 9.84 | 82 | 192269 | 7350 | 64299031 |
Personality disorder | 47.10 | 9.84 | 64 | 192287 | 4647 | 64301734 |
Dyskinesia | 46.16 | 9.84 | 236 | 192115 | 39152 | 64267229 |
Libido increased | 45.90 | 9.84 | 40 | 192311 | 1750 | 64304631 |
Bronchopulmonary aspergillosis | 45.10 | 9.84 | 3 | 192348 | 19082 | 64287299 |
Cardiac failure congestive | 45.02 | 9.84 | 218 | 192133 | 130362 | 64176019 |
Wound | 44.85 | 9.84 | 101 | 192250 | 76376 | 64230005 |
Oesophageal spasm | 44.78 | 9.84 | 46 | 192305 | 2479 | 64303902 |
Anti-cyclic citrullinated peptide antibody positive | 44.73 | 9.84 | 49 | 192302 | 49513 | 64256868 |
Lower respiratory tract infection | 44.10 | 9.84 | 140 | 192211 | 94474 | 64211907 |
Blood pressure increased | 43.91 | 9.84 | 741 | 191610 | 171811 | 64134570 |
Coronary artery disease | 43.12 | 9.84 | 71 | 192280 | 60362 | 64246019 |
Hyperaesthesia | 42.52 | 9.84 | 93 | 192258 | 9921 | 64296460 |
White blood cell count decreased | 42.30 | 9.84 | 286 | 192065 | 157551 | 64148830 |
Vision blurred | 41.98 | 9.84 | 433 | 191918 | 89883 | 64216498 |
Stomatitis | 41.97 | 9.84 | 176 | 192175 | 109429 | 64196952 |
Oedema peripheral | 41.77 | 9.84 | 413 | 191938 | 209904 | 64096477 |
Drug intolerance | 41.72 | 9.84 | 359 | 191992 | 187633 | 64118748 |
Muscle twitching | 41.53 | 9.84 | 138 | 192213 | 18860 | 64287521 |
Hyperkalaemia | 41.50 | 9.84 | 158 | 192193 | 100971 | 64205410 |
Intervertebral discitis | 41.01 | 9.84 | 54 | 192297 | 3803 | 64302578 |
Hot flush | 40.95 | 9.84 | 257 | 192094 | 45978 | 64260403 |
Endometrial ablation | 40.87 | 9.84 | 27 | 192324 | 774 | 64305607 |
Gastrointestinal haemorrhage | 40.51 | 9.84 | 230 | 192121 | 132082 | 64174299 |
Blister | 40.46 | 9.84 | 116 | 192235 | 80851 | 64225530 |
Reversible cerebral vasoconstriction syndrome | 40.34 | 9.84 | 42 | 192309 | 2300 | 64304081 |
Pneumocystis jirovecii pneumonia | 40.20 | 9.84 | 16 | 192335 | 27618 | 64278763 |
Temperature intolerance | 40.09 | 9.84 | 81 | 192270 | 8174 | 64298207 |
Self esteem decreased | 39.87 | 9.84 | 28 | 192323 | 889 | 64305492 |
Autonomic dysreflexia | 39.79 | 9.84 | 21 | 192330 | 392 | 64305989 |
Myoclonus | 39.44 | 9.84 | 164 | 192187 | 24954 | 64281427 |
Akathisia | 39.15 | 9.84 | 98 | 192253 | 11412 | 64294969 |
Alanine aminotransferase increased | 39.08 | 9.84 | 607 | 191744 | 138424 | 64167957 |
Muscle injury | 38.96 | 9.84 | 15 | 192336 | 26422 | 64279959 |
Influenza like illness | 38.93 | 9.84 | 316 | 192035 | 61386 | 64244995 |
Morbid thoughts | 38.33 | 9.84 | 25 | 192326 | 701 | 64305680 |
Discomfort | 38.16 | 9.84 | 119 | 192232 | 80759 | 64225622 |
Arthropathy | 37.73 | 9.84 | 209 | 192142 | 120758 | 64185623 |
Haemoptysis | 37.50 | 9.84 | 55 | 192296 | 48993 | 64257388 |
Restlessness | 37.03 | 9.84 | 224 | 192127 | 39561 | 64266820 |
Acute myeloid leukaemia | 36.64 | 9.84 | 18 | 192333 | 27445 | 64278936 |
Overdose | 36.58 | 9.84 | 674 | 191677 | 158892 | 64147489 |
Bone density abnormal | 36.52 | 9.84 | 43 | 192308 | 2702 | 64303679 |
Rapid eye movements sleep abnormal | 36.45 | 9.84 | 17 | 192334 | 240 | 64306141 |
Concussion | 36.33 | 9.84 | 76 | 192275 | 7862 | 64298519 |
Neck mass | 36.05 | 9.84 | 52 | 192299 | 3992 | 64302389 |
Cognitive disorder | 35.78 | 9.84 | 284 | 192067 | 54803 | 64251578 |
Gastrooesophageal reflux disease | 35.55 | 9.84 | 392 | 191959 | 82751 | 64223630 |
Dehydration | 35.38 | 9.84 | 445 | 191906 | 216318 | 64090063 |
Hostility | 35.21 | 9.84 | 38 | 192313 | 2169 | 64304212 |
Head injury | 35.20 | 9.84 | 192 | 192159 | 32650 | 64273731 |
Hypersomnia | 35.19 | 9.84 | 134 | 192217 | 19583 | 64286798 |
Angioedema | 35.15 | 9.84 | 83 | 192268 | 61738 | 64244643 |
Disseminated intravascular coagulation | 35.10 | 9.84 | 27 | 192324 | 32321 | 64274060 |
Sacroiliitis | 34.90 | 9.84 | 44 | 192307 | 2968 | 64303413 |
Aspergillus infection | 34.84 | 9.84 | 4 | 192347 | 16375 | 64290006 |
Pulmonary malformation | 34.84 | 9.84 | 14 | 192337 | 134 | 64306247 |
Bipolar disorder | 34.83 | 9.84 | 68 | 192283 | 6693 | 64299688 |
Rash maculo-papular | 34.73 | 9.84 | 54 | 192297 | 46972 | 64259409 |
Red blood cell sedimentation rate abnormal | 34.64 | 9.84 | 4 | 192347 | 16302 | 64290079 |
Opsoclonus myoclonus | 34.41 | 9.84 | 15 | 192336 | 179 | 64306202 |
Epistaxis | 34.30 | 9.84 | 163 | 192188 | 97968 | 64208413 |
Agranulocytosis | 34.27 | 9.84 | 38 | 192313 | 38191 | 64268190 |
Hypoaesthesia | 34.16 | 9.84 | 594 | 191757 | 138514 | 64167867 |
Sedation | 33.97 | 9.84 | 226 | 192125 | 41236 | 64265145 |
Hypotension | 33.86 | 9.84 | 871 | 191480 | 380103 | 63926278 |
Lactic acidosis | 33.69 | 9.84 | 84 | 192267 | 61326 | 64245055 |
Pulmonary fibrosis | 33.63 | 9.84 | 24 | 192327 | 29854 | 64276527 |
Libido decreased | 33.49 | 9.84 | 55 | 192296 | 4729 | 64301652 |
Rebound nasal congestion | 33.21 | 9.84 | 9 | 192342 | 19 | 64306362 |
C-reactive protein increased | 32.97 | 9.84 | 158 | 192193 | 94751 | 64211630 |
Bradyphrenia | 32.95 | 9.84 | 81 | 192270 | 9325 | 64297056 |
Melaena | 32.81 | 9.84 | 69 | 192282 | 53479 | 64252902 |
Muscle spasms | 32.79 | 9.84 | 597 | 191754 | 140426 | 64165955 |
Major depression | 32.52 | 9.84 | 72 | 192279 | 7744 | 64298637 |
Joint swelling | 32.29 | 9.84 | 450 | 191901 | 214932 | 64091449 |
Toxic epidermal necrolysis | 32.17 | 9.84 | 38 | 192313 | 37128 | 64269253 |
Aspartate aminotransferase increased | 32.15 | 9.84 | 519 | 191832 | 119269 | 64187112 |
Psychotic disorder due to a general medical condition | 32.03 | 9.84 | 16 | 192335 | 265 | 64306116 |
Impaired driving ability | 31.90 | 9.84 | 53 | 192298 | 4601 | 64301780 |
Nervousness | 31.82 | 9.84 | 173 | 192178 | 29383 | 64276998 |
Sleep apnoea syndrome | 31.70 | 9.84 | 174 | 192177 | 29658 | 64276723 |
Pneumonitis | 31.62 | 9.84 | 64 | 192287 | 50301 | 64256080 |
Cardiogenic shock | 31.60 | 9.84 | 30 | 192321 | 32397 | 64273984 |
Hypomagnesaemia | 31.52 | 9.84 | 39 | 192312 | 37337 | 64269044 |
Haematuria | 31.43 | 9.84 | 85 | 192266 | 60386 | 64245995 |
Ankle fracture | 31.40 | 9.84 | 106 | 192245 | 14604 | 64291777 |
Metabolic acidosis | 31.00 | 9.84 | 108 | 192243 | 70850 | 64235531 |
Respiratory distress | 30.77 | 9.84 | 69 | 192282 | 52262 | 64254119 |
Infection | 30.75 | 9.84 | 378 | 191973 | 184502 | 64121879 |
Road traffic accident | 30.47 | 9.84 | 176 | 192175 | 30569 | 64275812 |
Cerebral infarction | 30.43 | 9.84 | 47 | 192304 | 40997 | 64265384 |
Acute respiratory distress syndrome | 30.41 | 9.84 | 43 | 192308 | 38892 | 64267489 |
Neoplasm progression | 30.28 | 9.84 | 47 | 192304 | 40917 | 64265464 |
Palmar-plantar erythrodysaesthesia syndrome | 30.08 | 9.84 | 25 | 192326 | 28794 | 64277587 |
Sleep-related eating disorder | 30.06 | 9.84 | 21 | 192330 | 661 | 64305720 |
Aggression | 29.83 | 9.84 | 238 | 192113 | 45994 | 64260387 |
Tubulointerstitial nephritis | 29.65 | 9.84 | 29 | 192322 | 30880 | 64275501 |
Myocardial infarction | 29.51 | 9.84 | 334 | 192017 | 165487 | 64140894 |
Neuralgia | 29.37 | 9.84 | 155 | 192196 | 26029 | 64280352 |
Thunderclap headache | 29.15 | 9.84 | 14 | 192337 | 212 | 64306169 |
Metabolic surgery | 29.12 | 9.84 | 23 | 192328 | 876 | 64305505 |
Swelling | 28.79 | 9.84 | 322 | 192029 | 159896 | 64146485 |
Bacteraemia | 28.52 | 9.84 | 23 | 192328 | 26888 | 64279493 |
Hallucination, auditory | 28.50 | 9.84 | 113 | 192238 | 16826 | 64289555 |
Anovulatory cycle | 28.06 | 9.84 | 11 | 192340 | 98 | 64306283 |
Poor quality sleep | 27.64 | 9.84 | 121 | 192230 | 18830 | 64287551 |
Bradycardia | 27.46 | 9.84 | 223 | 192128 | 117996 | 64188385 |
Dissociation | 27.26 | 9.84 | 39 | 192312 | 2972 | 64303409 |
Rheumatoid nodule | 27.14 | 9.84 | 3 | 192348 | 12648 | 64293733 |
Anaphylactic reaction | 27.07 | 9.84 | 109 | 192242 | 68555 | 64237826 |
Speech disorder | 26.83 | 9.84 | 241 | 192110 | 48200 | 64258181 |
Bronchial haemorrhage | 26.79 | 9.84 | 25 | 192326 | 1197 | 64305184 |
Lung cyst | 26.68 | 9.84 | 12 | 192339 | 155 | 64306226 |
Premature delivery | 26.65 | 9.84 | 11 | 192340 | 18578 | 64287803 |
Paranoia | 26.65 | 9.84 | 108 | 192243 | 16244 | 64290137 |
Formication | 26.42 | 9.84 | 47 | 192304 | 4310 | 64302071 |
Cataplexy | 26.36 | 9.84 | 21 | 192330 | 810 | 64305571 |
Alcoholism | 26.27 | 9.84 | 41 | 192310 | 3376 | 64303005 |
Drug eruption | 26.20 | 9.84 | 42 | 192309 | 36094 | 64270287 |
Emotional disorder | 26.16 | 9.84 | 90 | 192261 | 12517 | 64293864 |
Hypokalaemia | 26.05 | 9.84 | 235 | 192116 | 121668 | 64184713 |
Anorgasmia | 25.95 | 9.84 | 22 | 192329 | 927 | 64305454 |
Enterococcal infection | 25.79 | 9.84 | 5 | 192346 | 13861 | 64292520 |
Graft versus host disease | 25.65 | 9.84 | 5 | 192346 | 13808 | 64292573 |
Analgesic drug level above therapeutic | 25.53 | 9.84 | 16 | 192335 | 418 | 64305963 |
Acute myocardial infarction | 25.43 | 9.84 | 114 | 192237 | 69604 | 64236777 |
Gait disturbance | 25.43 | 9.84 | 683 | 191668 | 171472 | 64134909 |
Haemorrhage | 25.34 | 9.84 | 136 | 192215 | 79215 | 64227166 |
Galactorrhoea | 25.27 | 9.84 | 39 | 192312 | 3180 | 64303201 |
Myelodysplastic syndrome | 25.18 | 9.84 | 27 | 192324 | 27552 | 64278829 |
Hyperglycaemia | 25.17 | 9.84 | 95 | 192256 | 60873 | 64245508 |
Eosinophilia | 25.10 | 9.84 | 47 | 192304 | 38029 | 64268352 |
Pseudomonas infection | 24.97 | 9.84 | 11 | 192340 | 17872 | 64288509 |
Blood lactate dehydrogenase increased | 24.41 | 9.84 | 38 | 192313 | 33040 | 64273341 |
Maternal exposure during breast feeding | 24.24 | 9.84 | 30 | 192321 | 1986 | 64304395 |
Cholestasis | 24.13 | 9.84 | 62 | 192289 | 44810 | 64261571 |
Depressive symptom | 24.12 | 9.84 | 46 | 192305 | 4450 | 64301931 |
Tumour lysis syndrome | 24.09 | 9.84 | 14 | 192337 | 19426 | 64286955 |
Delusion | 24.01 | 9.84 | 112 | 192239 | 17902 | 64288479 |
Psychomotor hyperactivity | 23.99 | 9.84 | 96 | 192255 | 14355 | 64292026 |
Psychotic disorder | 23.97 | 9.84 | 181 | 192170 | 34397 | 64271984 |
Therapeutic product effect incomplete | 23.32 | 9.84 | 436 | 191915 | 103046 | 64203335 |
Haematotoxicity | 23.26 | 9.84 | 5 | 192346 | 12891 | 64293490 |
Cytokine release syndrome | 23.09 | 9.84 | 17 | 192334 | 20812 | 64285569 |
Skin haemorrhage | 23.06 | 9.84 | 67 | 192284 | 8518 | 64297863 |
Demyelination | 23.04 | 9.84 | 58 | 192293 | 6776 | 64299605 |
Cystitis | 22.96 | 9.84 | 211 | 192140 | 42464 | 64263917 |
Hypoalbuminaemia | 22.95 | 9.84 | 12 | 192339 | 17662 | 64288719 |
Abdominal discomfort | 22.88 | 9.84 | 394 | 191957 | 181928 | 64124453 |
Pulseless electrical activity | 22.85 | 9.84 | 5 | 192346 | 12734 | 64293647 |
Speech sound disorder | 22.45 | 9.84 | 8 | 192343 | 53 | 64306328 |
International normalised ratio increased | 22.44 | 9.84 | 141 | 192210 | 79026 | 64227355 |
Post-traumatic neck syndrome | 22.38 | 9.84 | 28 | 192323 | 1874 | 64304507 |
Toxic skin eruption | 22.36 | 9.84 | 15 | 192336 | 19269 | 64287112 |
Pathogen resistance | 22.35 | 9.84 | 5 | 192346 | 12538 | 64293843 |
Feeling guilty | 22.34 | 9.84 | 19 | 192332 | 804 | 64305577 |
Depression suicidal | 22.32 | 9.84 | 32 | 192319 | 2443 | 64303938 |
Apathy | 22.28 | 9.84 | 79 | 192272 | 11153 | 64295228 |
Lactation disorder | 22.14 | 9.84 | 11 | 192340 | 180 | 64306201 |
Aplastic anaemia | 22.06 | 9.84 | 7 | 192344 | 13913 | 64292468 |
Antidepressant drug level above therapeutic | 22.03 | 9.84 | 16 | 192335 | 536 | 64305845 |
Drug screen positive | 21.86 | 9.84 | 51 | 192300 | 5678 | 64300703 |
Prescribed underdose | 21.85 | 9.84 | 109 | 192242 | 17906 | 64288475 |
Device related infection | 21.83 | 9.84 | 36 | 192315 | 30590 | 64275791 |
Spinal operation | 21.68 | 9.84 | 53 | 192298 | 6080 | 64300301 |
Sensitivity to weather change | 21.62 | 9.84 | 56 | 192295 | 6658 | 64299723 |
Hypoxia | 21.53 | 9.84 | 164 | 192187 | 87985 | 64218396 |
Hypnopompic hallucination | 21.49 | 9.84 | 8 | 192343 | 61 | 64306320 |
Pustular psoriasis | 21.46 | 9.84 | 42 | 192309 | 4141 | 64302240 |
Rheumatoid factor positive | 21.42 | 9.84 | 45 | 192306 | 34893 | 64271488 |
Irritable bowel syndrome | 21.38 | 9.84 | 50 | 192301 | 37319 | 64269062 |
Pulmonary eosinophilia | 21.28 | 9.84 | 16 | 192335 | 566 | 64305815 |
Proteinuria | 21.27 | 9.84 | 31 | 192320 | 27692 | 64278689 |
Metastases to liver | 21.24 | 9.84 | 24 | 192327 | 23917 | 64282464 |
Acute pulmonary oedema | 21.10 | 9.84 | 6 | 192345 | 12803 | 64293578 |
Metastases to bone | 21.00 | 9.84 | 18 | 192333 | 20417 | 64285964 |
Phagophobia | 20.97 | 9.84 | 7 | 192344 | 37 | 64306344 |
Gambling disorder | 20.89 | 9.84 | 27 | 192324 | 1867 | 64304514 |
Sexual dysfunction | 20.87 | 9.84 | 54 | 192297 | 6417 | 64299964 |
Product prescribing error | 20.84 | 9.84 | 178 | 192173 | 35091 | 64271290 |
Pulmonary oedema | 20.84 | 9.84 | 143 | 192208 | 78531 | 64227850 |
Impaired healing | 20.81 | 9.84 | 101 | 192250 | 60372 | 64246009 |
Thrombotic microangiopathy | 20.63 | 9.84 | 12 | 192339 | 16643 | 64289738 |
Epstein-Barr virus infection | 20.29 | 9.84 | 6 | 192345 | 12482 | 64293899 |
Poisoning | 20.24 | 9.84 | 123 | 192228 | 21756 | 64284625 |
Pain in extremity | 20.19 | 9.84 | 1101 | 191250 | 301984 | 64004397 |
Pulmonary haemorrhage | 20.06 | 9.84 | 7 | 192344 | 13102 | 64293279 |
Second primary malignancy | 19.91 | 9.84 | 6 | 192345 | 12331 | 64294050 |
Helicobacter infection | 19.87 | 9.84 | 54 | 192297 | 38308 | 64268073 |
Deep vein thrombosis | 19.85 | 9.84 | 209 | 192142 | 104973 | 64201408 |
Feeling jittery | 19.58 | 9.84 | 73 | 192278 | 10562 | 64295819 |
Tearfulness | 19.39 | 9.84 | 43 | 192308 | 4630 | 64301751 |
Neurologic neglect syndrome | 19.33 | 9.84 | 24 | 192327 | 1594 | 64304787 |
Ejection fraction decreased | 19.31 | 9.84 | 35 | 192316 | 28672 | 64277709 |
Initial insomnia | 19.30 | 9.84 | 49 | 192302 | 5755 | 64300626 |
Diarrhoea | 19.28 | 9.84 | 1875 | 190476 | 720829 | 63585552 |
Phobia of driving | 19.27 | 9.84 | 4 | 192347 | 0 | 64306381 |
Blood calcium decreased | 19.20 | 9.84 | 29 | 192322 | 25525 | 64280856 |
Peritonitis | 19.18 | 9.84 | 28 | 192323 | 24995 | 64281386 |
Ischaemic stroke | 19 | 9.84 | 36 | 192315 | 28999 | 64277382 |
Psoriatic arthropathy | 18.93 | 9.84 | 205 | 192146 | 43076 | 64263305 |
Muscle spasticity | 18.92 | 9.84 | 99 | 192252 | 16570 | 64289811 |
Carotid artery thrombosis | 18.88 | 9.84 | 25 | 192326 | 1770 | 64304611 |
Somnambulism | 18.79 | 9.84 | 45 | 192306 | 5096 | 64301285 |
Delirium | 18.63 | 9.84 | 300 | 192051 | 68894 | 64237487 |
Hypertonia | 18.59 | 9.84 | 51 | 192300 | 6274 | 64300107 |
Respiratory tract congestion | 18.34 | 9.84 | 96 | 192255 | 16069 | 64290312 |
Oesophageal pain | 18.27 | 9.84 | 34 | 192317 | 3229 | 64303152 |
Snoring | 18.22 | 9.84 | 42 | 192309 | 4640 | 64301741 |
Skin necrosis | 18.21 | 9.84 | 10 | 192341 | 14319 | 64292062 |
Arteriosclerosis coronary artery | 18.16 | 9.84 | 93 | 192258 | 15436 | 64290945 |
Increased appetite | 18.14 | 9.84 | 69 | 192282 | 10077 | 64296304 |
Bruxism | 18.13 | 9.84 | 36 | 192315 | 3588 | 64302793 |
Hepatic steatosis | 18.06 | 9.84 | 156 | 192195 | 30851 | 64275530 |
Sleep terror | 18.04 | 9.84 | 20 | 192331 | 1177 | 64305204 |
Haemolytic anaemia | 17.93 | 9.84 | 13 | 192338 | 16040 | 64290341 |
Middle insomnia | 17.86 | 9.84 | 81 | 192270 | 12796 | 64293585 |
Tension | 17.85 | 9.84 | 37 | 192314 | 3803 | 64302578 |
Scar | 17.64 | 9.84 | 83 | 192268 | 13315 | 64293066 |
Haemodialysis | 17.60 | 9.84 | 15 | 192336 | 17062 | 64289319 |
Neck pain | 17.41 | 9.84 | 269 | 192082 | 61264 | 64245117 |
Hyponatraemic encephalopathy | 17.36 | 9.84 | 11 | 192340 | 293 | 64306088 |
Nephropathy toxic | 17.31 | 9.84 | 16 | 192335 | 17498 | 64288883 |
Compulsive shopping | 17.23 | 9.84 | 16 | 192335 | 761 | 64305620 |
CYP3A4 polymorphism | 17.15 | 9.84 | 7 | 192344 | 70 | 64306311 |
Bronchial disorder | 17.13 | 9.84 | 26 | 192325 | 2089 | 64304292 |
Sleep talking | 17.12 | 9.84 | 18 | 192333 | 997 | 64305384 |
Spondyloarthropathy | 17.08 | 9.84 | 16 | 192335 | 770 | 64305611 |
Creatinine renal clearance decreased | 17.01 | 9.84 | 11 | 192340 | 14410 | 64291971 |
Feelings of worthlessness | 16.97 | 9.84 | 13 | 192338 | 473 | 64305908 |
Tenosynovitis | 16.97 | 9.84 | 7 | 192344 | 11826 | 64294555 |
Shoulder operation | 16.92 | 9.84 | 26 | 192325 | 2112 | 64304269 |
Pneumothorax | 16.91 | 9.84 | 29 | 192322 | 24269 | 64282112 |
Angina pectoris | 16.87 | 9.84 | 73 | 192278 | 45008 | 64261373 |
Diplopia | 16.84 | 9.84 | 137 | 192214 | 26628 | 64279753 |
Acute stress disorder | 16.82 | 9.84 | 12 | 192339 | 391 | 64305990 |
Flat affect | 16.73 | 9.84 | 24 | 192327 | 1833 | 64304548 |
Dyspnoea exertional | 16.70 | 9.84 | 140 | 192211 | 73590 | 64232791 |
Pre-existing condition improved | 16.67 | 9.84 | 41 | 192310 | 4721 | 64301660 |
Angina unstable | 16.67 | 9.84 | 13 | 192338 | 15454 | 64290927 |
Visual impairment | 16.65 | 9.84 | 312 | 192039 | 73765 | 64232616 |
Urinary incontinence | 16.64 | 9.84 | 173 | 192178 | 35978 | 64270403 |
Soft tissue injury | 16.62 | 9.84 | 22 | 192329 | 1557 | 64304824 |
Carcinoid tumour pulmonary | 16.45 | 9.84 | 11 | 192340 | 322 | 64306059 |
Hyperuricaemia | 16.37 | 9.84 | 5 | 192346 | 10186 | 64296195 |
Electric shock sensation | 16.36 | 9.84 | 11 | 192340 | 325 | 64306056 |
Peripheral swelling | 16.27 | 9.84 | 487 | 191864 | 208666 | 64097715 |
Sinus disorder | 16.24 | 9.84 | 96 | 192255 | 16812 | 64289569 |
Rapid eye movement sleep behaviour disorder | 16.21 | 9.84 | 11 | 192340 | 330 | 64306051 |
Cytomegalovirus viraemia | 16.20 | 9.84 | 6 | 192345 | 10822 | 64295559 |
Intentional dose omission | 16.05 | 9.84 | 45 | 192306 | 5607 | 64300774 |
Granulomatous liver disease | 16.02 | 9.84 | 19 | 192332 | 1203 | 64305178 |
Hypoglycaemia | 16.01 | 9.84 | 181 | 192170 | 89711 | 64216670 |
Rheumatic fever | 15.98 | 9.84 | 4 | 192347 | 9290 | 64297091 |
Clostridium difficile colitis | 15.92 | 9.84 | 36 | 192315 | 27187 | 64279194 |
Therapy non-responder | 15.90 | 9.84 | 123 | 192228 | 65776 | 64240605 |
Homicidal ideation | 15.87 | 9.84 | 32 | 192319 | 3225 | 64303156 |
Gastrointestinal disorder | 15.83 | 9.84 | 181 | 192170 | 89528 | 64216853 |
Feeling drunk | 15.80 | 9.84 | 37 | 192314 | 4130 | 64302251 |
Sinus congestion | 15.70 | 9.84 | 89 | 192262 | 15350 | 64291031 |
Basal cell carcinoma | 15.53 | 9.84 | 44 | 192307 | 30794 | 64275587 |
Ill-defined disorder | 15.49 | 9.84 | 73 | 192278 | 43979 | 64262402 |
Mydriasis | 15.40 | 9.84 | 88 | 192263 | 15224 | 64291157 |
Urinary hesitation | 15.36 | 9.84 | 33 | 192318 | 3477 | 64302904 |
Urinary tract infection | 15.35 | 9.84 | 841 | 191510 | 230755 | 64075626 |
Intervertebral disc protrusion | 15.32 | 9.84 | 108 | 192243 | 20083 | 64286298 |
Convulsive threshold lowered | 15.26 | 9.84 | 16 | 192335 | 883 | 64305498 |
Joint stiffness | 15.20 | 9.84 | 148 | 192203 | 30256 | 64276125 |
Decreased interest | 15.18 | 9.84 | 32 | 192319 | 3328 | 64303053 |
Intestinal perforation | 15.12 | 9.84 | 14 | 192337 | 15299 | 64291082 |
Haemolysis | 15.09 | 9.84 | 7 | 192344 | 11032 | 64295349 |
Diffuse large B-cell lymphoma | 15.07 | 9.84 | 6 | 192345 | 10355 | 64296026 |
Myocardial ischaemia | 15.06 | 9.84 | 29 | 192322 | 23222 | 64283159 |
Hyperbilirubinaemia | 15.04 | 9.84 | 25 | 192326 | 21180 | 64285201 |
Metastases to lung | 15.02 | 9.84 | 14 | 192337 | 15250 | 64291131 |
Poverty of speech | 14.97 | 9.84 | 13 | 192338 | 566 | 64305815 |
Scoliosis | 14.95 | 9.84 | 46 | 192305 | 6036 | 64300345 |
Hysterectomy | 14.95 | 9.84 | 41 | 192310 | 5044 | 64301337 |
Open reduction of fracture | 14.85 | 9.84 | 9 | 192342 | 221 | 64306160 |
Renal tubular necrosis | 14.83 | 9.84 | 27 | 192324 | 22083 | 64284298 |
Hepatotoxicity | 14.78 | 9.84 | 65 | 192286 | 39897 | 64266484 |
Oliguria | 14.78 | 9.84 | 13 | 192338 | 14563 | 64291818 |
Immobilisation prolonged | 14.75 | 9.84 | 7 | 192344 | 103 | 64306278 |
Rhonchi | 14.52 | 9.84 | 32 | 192319 | 3431 | 64302950 |
Klebsiella infection | 14.52 | 9.84 | 11 | 192340 | 13270 | 64293111 |
Blood urea increased | 14.47 | 9.84 | 75 | 192276 | 44078 | 64262303 |
Rectocele repair | 14.45 | 9.84 | 3 | 192348 | 0 | 64306381 |
Clitoral engorgement | 14.45 | 9.84 | 3 | 192348 | 0 | 64306381 |
Eye pain | 14.39 | 9.84 | 151 | 192200 | 31474 | 64274907 |
Dystonia | 14.36 | 9.84 | 101 | 192250 | 18764 | 64287617 |
Hyperventilation | 14.34 | 9.84 | 49 | 192302 | 6791 | 64299590 |
Lung disorder | 14.32 | 9.84 | 114 | 192237 | 60586 | 64245795 |
Circulatory collapse | 14.29 | 9.84 | 52 | 192299 | 33680 | 64272701 |
Illness anxiety disorder | 14.23 | 9.84 | 9 | 192342 | 239 | 64306142 |
Therapeutic product effect decreased | 14.23 | 9.84 | 250 | 192101 | 115101 | 64191280 |
Renal injury | 14.20 | 9.84 | 15 | 192336 | 15414 | 64290967 |
Dissociative disorder | 14.13 | 9.84 | 11 | 192340 | 410 | 64305971 |
Musculoskeletal discomfort | 14.11 | 9.84 | 90 | 192261 | 16187 | 64290194 |
Acute hepatic failure | 14.10 | 9.84 | 36 | 192315 | 26076 | 64280305 |
Therapeutic response changed | 14.07 | 9.84 | 16 | 192335 | 968 | 64305413 |
Tuberculosis | 14.00 | 9.84 | 11 | 192340 | 13027 | 64293354 |
Hospitalisation | 14.00 | 9.84 | 308 | 192043 | 74899 | 64231482 |
Live birth | 13.98 | 9.84 | 8 | 192343 | 11196 | 64295185 |
Asphyxia | 13.89 | 9.84 | 61 | 192290 | 9505 | 64296876 |
Joint noise | 13.84 | 9.84 | 30 | 192321 | 3181 | 64303200 |
Drug metabolising enzyme decreased | 13.76 | 9.84 | 4 | 192347 | 12 | 64306369 |
Torsade de pointes | 13.74 | 9.84 | 19 | 192332 | 17344 | 64289037 |
Hypervolaemia | 13.72 | 9.84 | 63 | 192288 | 38222 | 64268159 |
Hepatocellular carcinoma | 13.72 | 9.84 | 4 | 192347 | 8399 | 64297982 |
Right ventricular failure | 13.72 | 9.84 | 27 | 192324 | 21444 | 64284937 |
Drug screen false positive | 13.71 | 9.84 | 16 | 192335 | 996 | 64305385 |
Atelectasis | 13.66 | 9.84 | 39 | 192312 | 27227 | 64279154 |
Heart rate decreased | 13.66 | 9.84 | 102 | 192249 | 54965 | 64251416 |
Obsessive-compulsive personality disorder | 13.64 | 9.84 | 7 | 192344 | 123 | 64306258 |
Growth hormone deficiency | 13.62 | 9.84 | 10 | 192341 | 341 | 64306040 |
Radiation fibrosis | 13.56 | 9.84 | 5 | 192346 | 37 | 64306344 |
Impulse-control disorder | 13.55 | 9.84 | 20 | 192331 | 1568 | 64304813 |
Polyarthritis | 13.53 | 9.84 | 6 | 192345 | 9709 | 64296672 |
Pyometra | 13.52 | 9.84 | 6 | 192345 | 75 | 64306306 |
Lymphoma | 13.46 | 9.84 | 13 | 192338 | 13928 | 64292453 |
Bladder cancer | 13.46 | 9.84 | 8 | 192343 | 10966 | 64295415 |
Mean cell haemoglobin concentration increased | 13.35 | 9.84 | 14 | 192337 | 773 | 64305608 |
Respiratory tract malformation | 13.33 | 9.84 | 5 | 192346 | 39 | 64306342 |
Panic disorder | 13.33 | 9.84 | 27 | 192324 | 2730 | 64303651 |
Atrioventricular block complete | 13.29 | 9.84 | 14 | 192337 | 14404 | 64291977 |
Exposure via breast milk | 13.25 | 9.84 | 14 | 192337 | 780 | 64305601 |
Parosmia | 13.23 | 9.84 | 37 | 192314 | 4603 | 64301778 |
Immunisation reaction | 13.22 | 9.84 | 5 | 192346 | 40 | 64306341 |
Haemophagocytic lymphohistiocytosis | 13.21 | 9.84 | 20 | 192331 | 17589 | 64288792 |
Status epilepticus | 13.20 | 9.84 | 28 | 192323 | 21635 | 64284746 |
Oesophagitis | 13.14 | 9.84 | 28 | 192323 | 21602 | 64284779 |
Pneumonia fungal | 13.14 | 9.84 | 5 | 192346 | 8872 | 64297509 |
Eyelid myoclonus | 13.12 | 9.84 | 5 | 192346 | 41 | 64306340 |
Shock | 13.08 | 9.84 | 64 | 192287 | 38176 | 64268205 |
Coagulopathy | 13.00 | 9.84 | 50 | 192301 | 31870 | 64274511 |
Accidental death | 12.97 | 9.84 | 32 | 192319 | 3693 | 64302688 |
Ophthalmic vein thrombosis | 12.90 | 9.84 | 8 | 192343 | 205 | 64306176 |
Respiratory arrest | 12.90 | 9.84 | 226 | 192125 | 52759 | 64253622 |
Burning sensation | 12.88 | 9.84 | 214 | 192137 | 49450 | 64256931 |
Hyponatraemia | 12.83 | 9.84 | 553 | 191798 | 147786 | 64158595 |
Metastases to lymph nodes | 12.76 | 9.84 | 5 | 192346 | 8712 | 64297669 |
Febrile bone marrow aplasia | 12.72 | 9.84 | 9 | 192342 | 11246 | 64295135 |
Anaphylactic shock | 12.68 | 9.84 | 47 | 192304 | 30281 | 64276100 |
Pericardial effusion | 12.68 | 9.84 | 67 | 192284 | 39187 | 64267194 |
Gastric ulcer | 12.55 | 9.84 | 47 | 192304 | 30187 | 64276194 |
Retrograde ejaculation | 12.53 | 9.84 | 8 | 192343 | 216 | 64306165 |
Gastric haemorrhage | 12.53 | 9.84 | 13 | 192338 | 13468 | 64292913 |
Skin lesion | 12.51 | 9.84 | 61 | 192290 | 36421 | 64269960 |
Muscular weakness | 12.46 | 9.84 | 481 | 191870 | 126857 | 64179524 |
Movement disorder | 12.46 | 9.84 | 110 | 192241 | 21890 | 64284491 |
Suspected suicide | 12.43 | 9.84 | 55 | 192296 | 8599 | 64297782 |
Psychopathic personality | 12.38 | 9.84 | 3 | 192348 | 3 | 64306378 |
Floating patella | 12.38 | 9.84 | 3 | 192348 | 3 | 64306378 |
Tachyphrenia | 12.37 | 9.84 | 21 | 192330 | 1855 | 64304526 |
Panic reaction | 12.37 | 9.84 | 33 | 192318 | 3994 | 64302387 |
Labelled drug-food interaction issue | 12.33 | 9.84 | 4 | 192347 | 19 | 64306362 |
Hypercalcaemia | 12.30 | 9.84 | 50 | 192301 | 31366 | 64275015 |
Illusion | 12.30 | 9.84 | 19 | 192332 | 1551 | 64304830 |
Haemoglobin urine present | 12.29 | 9.84 | 14 | 192337 | 849 | 64305532 |
Metastases to central nervous system | 12.28 | 9.84 | 14 | 192337 | 13898 | 64292483 |
Axillary pain | 12.24 | 9.84 | 20 | 192331 | 1712 | 64304669 |
Adjustment disorder | 12.23 | 9.84 | 26 | 192325 | 2719 | 64303662 |
Chronic kidney disease | 12.22 | 9.84 | 112 | 192239 | 57807 | 64248574 |
Loose tooth | 12.17 | 9.84 | 27 | 192324 | 2907 | 64303474 |
Acute respiratory failure | 12.14 | 9.84 | 93 | 192258 | 49841 | 64256540 |
Posterior reversible encephalopathy syndrome | 12.11 | 9.84 | 32 | 192319 | 22914 | 64283467 |
Sinus tachycardia | 12.08 | 9.84 | 148 | 192203 | 32040 | 64274341 |
Sternal fracture | 12.07 | 9.84 | 23 | 192328 | 2224 | 64304157 |
Transfusion | 12.05 | 9.84 | 22 | 192329 | 17972 | 64288409 |
Forced expiratory flow decreased | 12.03 | 9.84 | 8 | 192343 | 232 | 64306149 |
Palpitations | 12.02 | 9.84 | 402 | 191949 | 104086 | 64202295 |
Anal incontinence | 11.95 | 9.84 | 82 | 192269 | 15114 | 64291267 |
Night sweats | 11.95 | 9.84 | 162 | 192189 | 35884 | 64270497 |
Feeling hot | 11.93 | 9.84 | 197 | 192154 | 45466 | 64260915 |
Abulia | 11.92 | 9.84 | 14 | 192337 | 877 | 64305504 |
Bipolar I disorder | 11.91 | 9.84 | 20 | 192331 | 1751 | 64304630 |
Trigger finger | 11.86 | 9.84 | 30 | 192321 | 3515 | 64302866 |
Blood bilirubin increased | 11.84 | 9.84 | 112 | 192239 | 57441 | 64248940 |
Ocular vascular disorder | 11.82 | 9.84 | 10 | 192341 | 420 | 64305961 |
Red blood cell count decreased | 11.82 | 9.84 | 90 | 192261 | 48296 | 64258085 |
Supraventricular tachyarrhythmia | 11.82 | 9.84 | 6 | 192345 | 103 | 64306278 |
Pancreatitis acute | 11.80 | 9.84 | 77 | 192274 | 42778 | 64263603 |
Cholangitis | 11.74 | 9.84 | 9 | 192342 | 10793 | 64295588 |
Prostate cancer | 11.72 | 9.84 | 26 | 192325 | 19769 | 64286612 |
Social avoidant behaviour | 11.70 | 9.84 | 35 | 192316 | 4522 | 64301859 |
Nephrotic syndrome | 11.70 | 9.84 | 7 | 192344 | 9560 | 64296821 |
Acute graft versus host disease in skin | 11.69 | 9.84 | 3 | 192348 | 6852 | 64299529 |
Post concussion syndrome | 11.63 | 9.84 | 11 | 192340 | 536 | 64305845 |
Impulsive behaviour | 11.61 | 9.84 | 25 | 192326 | 2638 | 64303743 |
Escherichia infection | 11.60 | 9.84 | 17 | 192334 | 15151 | 64291230 |
Drug abuse | 11.57 | 9.84 | 494 | 191857 | 131880 | 64174501 |
Facial spasm | 11.48 | 9.84 | 12 | 192339 | 660 | 64305721 |
Infective pulmonary exacerbation of cystic fibrosis | 11.39 | 9.84 | 11 | 192340 | 11785 | 64294596 |
Ligament injury | 11.33 | 9.84 | 15 | 192336 | 1062 | 64305319 |
Progressive multifocal leukoencephalopathy | 11.29 | 9.84 | 93 | 192258 | 18139 | 64288242 |
Economic problem | 11.27 | 9.84 | 22 | 192329 | 2165 | 64304216 |
Sciatic nerve injury | 11.22 | 9.84 | 10 | 192341 | 451 | 64305930 |
Somatic delusion | 11.22 | 9.84 | 12 | 192339 | 678 | 64305703 |
Complex regional pain syndrome | 11.21 | 9.84 | 19 | 192332 | 1677 | 64304704 |
Purple glove syndrome | 11.17 | 9.84 | 8 | 192343 | 262 | 64306119 |
Holmes-Adie pupil | 11.16 | 9.84 | 4 | 192347 | 27 | 64306354 |
Embolism | 11.14 | 9.84 | 12 | 192339 | 12223 | 64294158 |
Lung infiltration | 11.13 | 9.84 | 29 | 192322 | 20860 | 64285521 |
Haemodynamic instability | 11.13 | 9.84 | 17 | 192334 | 14895 | 64291486 |
Cerebral haemorrhage | 11.12 | 9.84 | 98 | 192253 | 50992 | 64255389 |
Liver function test increased | 11.08 | 9.84 | 51 | 192300 | 30919 | 64275462 |
Dysphemia | 11.08 | 9.84 | 27 | 192324 | 3092 | 64303289 |
Trismus | 11.07 | 9.84 | 36 | 192315 | 4865 | 64301516 |
Exposure via ingestion | 11.06 | 9.84 | 36 | 192315 | 4866 | 64301515 |
Rib fracture | 11.04 | 9.84 | 115 | 192236 | 23923 | 64282458 |
Bone erosion | 10.98 | 9.84 | 11 | 192340 | 11584 | 64294797 |
Serum serotonin increased | 10.96 | 9.84 | 8 | 192343 | 270 | 64306111 |
Adiposis dolorosa | 10.94 | 9.84 | 8 | 192343 | 271 | 64306110 |
Rhabdomyolysis | 10.93 | 9.84 | 200 | 192151 | 91526 | 64214855 |
Cardiac failure acute | 10.93 | 9.84 | 20 | 192331 | 16324 | 64290057 |
Blood bilirubin | 10.92 | 9.84 | 4 | 192347 | 29 | 64306352 |
Lymphadenopathy | 10.86 | 9.84 | 88 | 192263 | 46598 | 64259783 |
Tethered cord syndrome | 10.86 | 9.84 | 3 | 192348 | 7 | 64306374 |
Drug level decreased | 10.80 | 9.84 | 11 | 192340 | 11492 | 64294889 |
Multiple-drug resistance | 10.79 | 9.84 | 3 | 192348 | 6499 | 64299882 |
Large intestine perforation | 10.79 | 9.84 | 13 | 192338 | 12591 | 64293790 |
Device expulsion | 10.76 | 9.84 | 30 | 192321 | 21106 | 64285275 |
Rales | 10.76 | 9.84 | 18 | 192333 | 15211 | 64291170 |
Cholecystectomy | 10.75 | 9.84 | 50 | 192301 | 7982 | 64298399 |
Tachyphylaxis | 10.74 | 9.84 | 8 | 192343 | 279 | 64306102 |
Impaired work ability | 10.73 | 9.84 | 80 | 192271 | 15139 | 64291242 |
Pulmonary alveolar haemorrhage | 10.73 | 9.84 | 8 | 192343 | 9730 | 64296651 |
Allodynia | 10.72 | 9.84 | 16 | 192335 | 1267 | 64305114 |
Gambling | 10.69 | 9.84 | 8 | 192343 | 281 | 64306100 |
Hypogammaglobulinaemia | 10.67 | 9.84 | 9 | 192342 | 10290 | 64296091 |
Stress | 10.66 | 9.84 | 246 | 192105 | 60288 | 64246093 |
Product use issue | 10.65 | 9.84 | 358 | 191993 | 151357 | 64155024 |
Dysstasia | 10.64 | 9.84 | 111 | 192240 | 23104 | 64283277 |
Alveolar bone resorption | 10.63 | 9.84 | 5 | 192346 | 72 | 64306309 |
Delirium tremens | 10.61 | 9.84 | 11 | 192340 | 599 | 64305782 |
Regurgitation | 10.61 | 9.84 | 21 | 192330 | 2088 | 64304293 |
Dysphagia | 10.58 | 9.84 | 404 | 191947 | 106408 | 64199973 |
Relapsing multiple sclerosis | 10.57 | 9.84 | 5 | 192346 | 73 | 64306308 |
Intervertebral disc operation | 10.55 | 9.84 | 12 | 192339 | 726 | 64305655 |
Vasculitis | 10.52 | 9.84 | 24 | 192327 | 18071 | 64288310 |
Arthroscopy | 10.51 | 9.84 | 10 | 192341 | 491 | 64305890 |
Ventricular hypokinesia | 10.50 | 9.84 | 5 | 192346 | 7764 | 64298617 |
Hepatic cytolysis | 10.50 | 9.84 | 16 | 192335 | 14033 | 64292348 |
Central nervous system stimulation | 10.47 | 9.84 | 4 | 192347 | 33 | 64306348 |
Rectal haemorrhage | 10.41 | 9.84 | 126 | 192225 | 61691 | 64244690 |
Osteonecrosis | 10.39 | 9.84 | 46 | 192305 | 28183 | 64278198 |
Cycloplegia | 10.32 | 9.84 | 3 | 192348 | 9 | 64306372 |
Skin plaque | 10.30 | 9.84 | 7 | 192344 | 8933 | 64297448 |
Osteonecrosis of jaw | 10.24 | 9.84 | 73 | 192278 | 39752 | 64266629 |
Productive cough | 10.23 | 9.84 | 155 | 192196 | 73048 | 64233333 |
Bacterial infection | 10.22 | 9.84 | 39 | 192312 | 24911 | 64281470 |
Intestinal cyst | 10.21 | 9.84 | 6 | 192345 | 139 | 64306242 |
Leukoencephalopathy | 10.19 | 9.84 | 4 | 192347 | 6963 | 64299418 |
Cushingoid | 10.12 | 9.84 | 5 | 192346 | 7598 | 64298783 |
Hepatitis E antibody positive | 10.10 | 9.84 | 6 | 192345 | 142 | 64306239 |
Narcissistic personality disorder | 10.09 | 9.84 | 3 | 192348 | 10 | 64306371 |
Hepatic enzyme increased | 10.06 | 9.84 | 479 | 191872 | 129464 | 64176917 |
Blood pressure systolic decreased | 10.04 | 9.84 | 7 | 192344 | 8813 | 64297568 |
Communication disorder | 10.03 | 9.84 | 29 | 192322 | 3677 | 64302704 |
Eating disorder | 10.03 | 9.84 | 85 | 192266 | 16720 | 64289661 |
Bone density decreased | 9.94 | 9.84 | 9 | 192342 | 9943 | 64296438 |
Inflammation | 9.92 | 9.84 | 136 | 192215 | 65164 | 64241217 |
Cephalo-pelvic disproportion | 9.92 | 9.84 | 6 | 192345 | 147 | 64306234 |
Breakthrough pain | 9.89 | 9.84 | 15 | 192336 | 1205 | 64305176 |
Knee operation | 9.87 | 9.84 | 33 | 192318 | 4524 | 64301857 |
None
Source | Code | Description |
---|---|---|
ATC | N06AX21 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D000068760 | Serotonin and Noradrenaline Reuptake Inhibitors |
FDA EPC | N0000175749 | Serotonin and Norepinephrine Reuptake Inhibitor |
CHEBI has role | CHEBI:35469 | antidepressants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Female stress incontinence | indication | 60241006 | DOID:724 |
Fibromyalgia | indication | 203082005 | DOID:631 |
Major depressive disorder | indication | 370143000 | |
Diabetic peripheral neuropathy | indication | 424736006 | |
Chronic Musculoskeletal Pain | indication | ||
Osteoarthritis | off-label use | 396275006 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Jaundice | contraindication | 18165001 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Orthostatic hypotension | contraindication | 28651003 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Alcoholic liver damage | contraindication | 41309000 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Chronic hepatitis | contraindication | 76783007 | DOID:2237 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Inflammatory disease of liver | contraindication | 128241005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Serotonin syndrome | contraindication | 371089000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastrointestinal hypomotility | contraindication | 421807004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.7 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 20MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
EQ 30MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
EQ 60MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 9.62 | CHEMBL | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 8.22 | CHEMBL | CHEMBL | |||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.30 | PDSP | |||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 6.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.68 | PDSP | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6 | IUPHAR | ||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 6.40 | IUPHAR | ||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.65 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 5.64 | PDSP | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.40 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.52 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.62 | CHEMBL | |||||
5-hydroxytryptamine receptor 1F | GPCR | Ki | 5.35 | PDSP | |||||
5-hydroxytryptamine receptor 1E | GPCR | Ki | 5.43 | PDSP | |||||
Serine hydroxymethyltransferase, mitochondrial | Enzyme | IC50 | 5.16 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 10.09 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 6.43 | CHEMBL | |||||
Transporter | Transporter | Ki | 8.52 | CHEMBL |
ID | Source |
---|---|
D01179 | KEGG_DRUG |
136434-34-9 | SECONDARY_CAS_RN |
4021477 | VANDF |
C0245561 | UMLSCUI |
CHEBI:31526 | CHEBI |
29E | PDB_CHEM_ID |
CHEMBL1175 | ChEMBL_ID |
CHEMBL1200328 | ChEMBL_ID |
DB00476 | DRUGBANK_ID |
D000068736 | MESH_DESCRIPTOR_UI |
60835 | PUBCHEM_CID |
202 | IUPHAR_LIGAND_ID |
7012 | INN_ID |
O5TNM5N07U | UNII |
476250 | RXNORM |
18760 | MMSL |
208014 | MMSL |
33554 | MMSL |
59319 | MMSL |
d05355 | MMSL |
008705 | NDDF |
008707 | NDDF |
407032004 | SNOMEDCT_US |
407033009 | SNOMEDCT_US |
426892003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3235 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3240 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3270 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | NDA | 36 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2890 | CAPSULE, DELAYED RELEASE PELLETS | 20 mg | ORAL | ANDA | 29 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2891 | CAPSULE, DELAYED RELEASE PELLETS | 30 mg | ORAL | ANDA | 29 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2892 | CAPSULE, DELAYED RELEASE PELLETS | 60 mg | ORAL | ANDA | 29 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8203 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8204 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8290 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6452 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6453 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6454 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7043 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7044 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7045 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-111 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-111 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-145 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | NDA | 34 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-146 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | NDA | 34 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-657 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 34 sections |
Duloxetine | Human Prescription Drug Label | 1 | 25000-608 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 35 sections |
Duloxetine | Human Prescription Drug Label | 1 | 25000-609 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 35 sections |
Duloxetine | Human Prescription Drug Label | 1 | 25000-610 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 35 sections |
Duloxetine | Human Prescription Drug Label | 1 | 27241-097 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
Duloxetine | Human Prescription Drug Label | 1 | 27241-098 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine | Human Prescription Drug Label | 1 | 27241-099 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |