Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 972 | 116539-59-4 |
Dose | Unit | Route |
---|---|---|
60 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.88 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
CL (Clearance) | 8.57 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 3, 2004 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 4079.64 | 10.00 | 2008 | 236838 | 25186 | 63224990 |
Dysphoria | 3522.88 | 10.00 | 1129 | 237717 | 3837 | 63246339 |
Affect lability | 2782.04 | 10.00 | 1174 | 237672 | 9977 | 63240199 |
Irritability | 2255.42 | 10.00 | 1434 | 237412 | 30260 | 63219916 |
Suicidal ideation | 2034.84 | 10.00 | 1765 | 237081 | 60656 | 63189520 |
Agitation | 1774.72 | 10.00 | 1603 | 237243 | 58154 | 63192022 |
Sensory disturbance | 1314.97 | 10.00 | 751 | 238095 | 12921 | 63237255 |
Hyperhidrosis | 1288.74 | 10.00 | 1798 | 237048 | 106038 | 63144138 |
Vertigo | 1216.80 | 10.00 | 1306 | 237540 | 58581 | 63191595 |
Paraesthesia | 1186.48 | 10.00 | 2121 | 236725 | 154845 | 63095331 |
Insomnia | 1077.79 | 10.00 | 2450 | 236396 | 212802 | 63037374 |
Anxiety | 1038.45 | 10.00 | 2430 | 236416 | 215111 | 63035065 |
Nightmare | 818.41 | 10.00 | 635 | 238211 | 18559 | 63231617 |
Mood swings | 750.53 | 10.00 | 591 | 238255 | 17657 | 63232519 |
Dizziness | 694.02 | 10.00 | 3324 | 235522 | 426601 | 62823575 |
Pemphigus | 672.85 | 10.00 | 3 | 238843 | 183723 | 63066453 |
Serotonin syndrome | 643.81 | 10.00 | 660 | 238186 | 28022 | 63222154 |
Tremor | 603.76 | 10.00 | 1453 | 237393 | 130786 | 63119390 |
Tinnitus | 583.54 | 10.00 | 695 | 238151 | 34933 | 63215243 |
Lethargy | 529.08 | 10.00 | 837 | 238009 | 55170 | 63195006 |
Glossodynia | 507.04 | 10.00 | 45 | 238801 | 178831 | 63071345 |
Hypomania | 481.50 | 10.00 | 299 | 238547 | 6031 | 63244145 |
Hand deformity | 454.94 | 10.00 | 39 | 238807 | 159418 | 63090758 |
Confusional state | 437.75 | 10.00 | 1905 | 236941 | 234475 | 63015701 |
Systemic lupus erythematosus | 403.57 | 10.00 | 141 | 238705 | 208777 | 63041399 |
Alopecia | 400.15 | 10.00 | 408 | 238438 | 337128 | 62913048 |
Contraindicated product administered | 379.29 | 10.00 | 172 | 238674 | 217476 | 63032700 |
Pericarditis | 365.09 | 10.00 | 36 | 238810 | 131543 | 63118633 |
Withdrawal syndrome | 364.07 | 10.00 | 412 | 238434 | 19585 | 63230591 |
Synovitis | 356.12 | 10.00 | 129 | 238717 | 186789 | 63063387 |
Wound | 342.45 | 10.00 | 95 | 238751 | 163168 | 63087008 |
Headache | 340.39 | 10.00 | 3756 | 235090 | 629485 | 62620691 |
Suicide attempt | 328.20 | 10.00 | 715 | 238131 | 60203 | 63189973 |
Duodenal ulcer perforation | 306.67 | 10.00 | 4 | 238842 | 87205 | 63162971 |
Maternal exposure during pregnancy | 286.50 | 10.00 | 244 | 238602 | 219818 | 63030358 |
Arthropathy | 285.84 | 10.00 | 277 | 238569 | 234515 | 63015661 |
Nausea | 278.54 | 10.00 | 4631 | 234215 | 849840 | 62400336 |
Drug intolerance | 277.20 | 10.00 | 459 | 238387 | 308202 | 62941974 |
Abdominal discomfort | 276.45 | 10.00 | 490 | 238356 | 320395 | 62929781 |
Anti-cyclic citrullinated peptide antibody positive | 274.79 | 10.00 | 52 | 238794 | 116160 | 63134016 |
Treatment failure | 266.11 | 10.00 | 215 | 238631 | 198828 | 63051348 |
Depression | 261.81 | 10.00 | 1442 | 237404 | 195050 | 63055126 |
Infusion related reaction | 257.85 | 10.00 | 327 | 238519 | 245194 | 63004982 |
Discomfort | 248.19 | 10.00 | 162 | 238684 | 167212 | 63082964 |
Completed suicide | 246.72 | 10.00 | 1144 | 237702 | 144529 | 63105647 |
Feeling abnormal | 242.28 | 10.00 | 1153 | 237693 | 147239 | 63102937 |
Stubbornness | 241.26 | 10.00 | 79 | 238767 | 292 | 63249884 |
Febrile neutropenia | 240.84 | 10.00 | 73 | 238773 | 118376 | 63131800 |
Swelling | 223.39 | 10.00 | 436 | 238410 | 274942 | 62975234 |
Joint swelling | 223.18 | 10.00 | 571 | 238275 | 327095 | 62923081 |
Neutropenia | 221.72 | 10.00 | 199 | 238647 | 174806 | 63075370 |
Pyrexia | 211.34 | 10.00 | 981 | 237865 | 469497 | 62780679 |
Disturbance in attention | 211.09 | 10.00 | 453 | 238393 | 37736 | 63212440 |
Crying | 209.56 | 10.00 | 341 | 238505 | 23002 | 63227174 |
Folliculitis | 203.78 | 10.00 | 16 | 238830 | 70301 | 63179875 |
Rash | 200.34 | 10.00 | 1263 | 237583 | 559608 | 62690568 |
Hypersensitivity | 198.53 | 10.00 | 511 | 238335 | 292174 | 62958002 |
Helicobacter infection | 190.76 | 10.00 | 56 | 238790 | 92729 | 63157447 |
Anaemia | 187.93 | 10.00 | 527 | 238319 | 292903 | 62957273 |
Somnolence | 182.40 | 10.00 | 1224 | 237622 | 177461 | 63072715 |
Mood altered | 181.98 | 10.00 | 250 | 238596 | 14493 | 63235683 |
Muscle injury | 180.88 | 10.00 | 18 | 238828 | 65327 | 63184849 |
Rheumatoid factor positive | 177.12 | 10.00 | 49 | 238797 | 84357 | 63165819 |
Therapeutic product effect decreased | 173.52 | 10.00 | 287 | 238559 | 192900 | 63057276 |
Sleep disorder due to general medical condition, insomnia type | 173.16 | 10.00 | 5 | 238841 | 52212 | 63197964 |
Thinking abnormal | 168.26 | 10.00 | 204 | 238642 | 10439 | 63239737 |
General physical health deterioration | 167.50 | 10.00 | 314 | 238532 | 201088 | 63049088 |
Lower respiratory tract infection | 166.88 | 10.00 | 151 | 238695 | 132156 | 63118020 |
Thrombocytopenia | 166.32 | 10.00 | 194 | 238652 | 150963 | 63099213 |
Blister | 159.19 | 10.00 | 152 | 238694 | 129662 | 63120514 |
Sleep disorder | 158.78 | 10.00 | 668 | 238178 | 80898 | 63169278 |
C-reactive protein abnormal | 150.74 | 10.00 | 5 | 238841 | 46091 | 63204085 |
Electric shock | 147.33 | 10.00 | 80 | 238766 | 1240 | 63248936 |
Panic attack | 143.59 | 10.00 | 282 | 238564 | 22049 | 63228127 |
Pancytopenia | 143.38 | 10.00 | 94 | 238752 | 96839 | 63153337 |
Off label use | 141.16 | 10.00 | 1743 | 237103 | 672719 | 62577457 |
Product use issue | 135.29 | 10.00 | 404 | 238442 | 220116 | 63030060 |
Impaired healing | 134.17 | 10.00 | 113 | 238733 | 102429 | 63147747 |
Anger | 129.95 | 10.00 | 195 | 238651 | 12261 | 63237915 |
Depressed mood | 128.97 | 10.00 | 388 | 238458 | 39803 | 63210373 |
Coordination abnormal | 128.81 | 10.00 | 205 | 238641 | 13568 | 63236608 |
Memory impairment | 128.03 | 10.00 | 749 | 238097 | 103509 | 63146667 |
Infection | 121.23 | 10.00 | 448 | 238398 | 228725 | 63021451 |
Disease progression | 118.15 | 10.00 | 174 | 238672 | 122584 | 63127592 |
Stomatitis | 116.42 | 10.00 | 215 | 238631 | 138510 | 63111666 |
Abnormal behaviour | 115.91 | 10.00 | 252 | 238594 | 21174 | 63229002 |
Fatigue | 115.33 | 10.00 | 4249 | 234597 | 883779 | 62366397 |
Affective disorder | 114.19 | 10.00 | 128 | 238718 | 6018 | 63244158 |
Acute kidney injury | 110.03 | 10.00 | 563 | 238283 | 262852 | 62987324 |
Migraine | 109.01 | 10.00 | 714 | 238132 | 102632 | 63147544 |
Fall | 108.57 | 10.00 | 2075 | 236771 | 390259 | 62859917 |
Drug interaction | 107.95 | 10.00 | 1327 | 237519 | 227804 | 63022372 |
Inappropriate antidiuretic hormone secretion | 105.21 | 10.00 | 200 | 238646 | 15262 | 63234914 |
Malignant neoplasm progression | 103.19 | 10.00 | 94 | 238752 | 82027 | 63168149 |
Tardive dyskinesia | 103.17 | 10.00 | 143 | 238703 | 8359 | 63241817 |
Post-traumatic stress disorder | 100.38 | 10.00 | 111 | 238735 | 5140 | 63245036 |
Multiple sclerosis | 99.63 | 10.00 | 257 | 238589 | 24115 | 63226061 |
Platelet count decreased | 97.40 | 10.00 | 180 | 238666 | 115942 | 63134234 |
Peripheral swelling | 96.62 | 10.00 | 595 | 238251 | 265347 | 62984829 |
Drug ineffective | 94.92 | 10.00 | 3105 | 235741 | 1041660 | 62208516 |
Ill-defined disorder | 94.18 | 10.00 | 101 | 238745 | 81654 | 63168522 |
Hallucination | 93.78 | 10.00 | 432 | 238414 | 54385 | 63195791 |
Multiple sclerosis relapse | 89.66 | 10.00 | 391 | 238455 | 48087 | 63202089 |
Pneumonia aspiration | 88.69 | 10.00 | 309 | 238537 | 34231 | 63215945 |
Gastrointestinal tube insertion | 87.65 | 10.00 | 54 | 238792 | 1073 | 63249103 |
Coma | 87.31 | 10.00 | 475 | 238371 | 63889 | 63186287 |
Somatic symptom disorder | 86.08 | 10.00 | 75 | 238771 | 2585 | 63247591 |
Septic shock | 85.23 | 10.00 | 75 | 238771 | 66554 | 63183622 |
Irritable bowel syndrome | 85.10 | 10.00 | 111 | 238735 | 82301 | 63167875 |
Loss of consciousness | 84.52 | 10.00 | 745 | 238101 | 117376 | 63132800 |
Dyspnoea | 84.24 | 10.00 | 1872 | 236974 | 659441 | 62590735 |
Cardiac failure | 84.16 | 10.00 | 128 | 238718 | 89014 | 63161162 |
Gastric bypass | 83.77 | 10.00 | 63 | 238783 | 1754 | 63248422 |
Intentional product misuse | 82.25 | 10.00 | 449 | 238397 | 60468 | 63189708 |
Product substitution issue | 80.74 | 10.00 | 183 | 238663 | 15813 | 63234363 |
Aggression | 79.33 | 10.00 | 231 | 238615 | 23267 | 63226909 |
Pulmonary fibrosis | 78.27 | 10.00 | 26 | 238820 | 39783 | 63210393 |
Restless legs syndrome | 77.39 | 10.00 | 197 | 238649 | 18334 | 63231842 |
Opsoclonus myoclonus | 72.99 | 10.00 | 26 | 238820 | 131 | 63250045 |
White blood cell count abnormal | 72.78 | 10.00 | 103 | 238743 | 6139 | 63244037 |
Abnormal dreams | 72.75 | 10.00 | 137 | 238709 | 10379 | 63239797 |
Premature delivery | 72.72 | 10.00 | 13 | 238833 | 30268 | 63219908 |
Reversible cerebral vasoconstriction syndrome | 72.36 | 10.00 | 68 | 238778 | 2590 | 63247586 |
Gastrointestinal disorder | 71.69 | 10.00 | 253 | 238593 | 130986 | 63119190 |
Nasal turbinate hypertrophy | 70.90 | 10.00 | 41 | 238805 | 722 | 63249454 |
Myelosuppression | 69.78 | 10.00 | 5 | 238841 | 23698 | 63226478 |
Personality disorder | 69.40 | 10.00 | 97 | 238749 | 5714 | 63244462 |
Neutrophil count decreased | 69.17 | 10.00 | 66 | 238780 | 56340 | 63193836 |
Hip arthroplasty | 68.04 | 10.00 | 48 | 238798 | 47598 | 63202578 |
Influenza like illness | 67.62 | 10.00 | 457 | 238389 | 66367 | 63183809 |
Erythema | 67.60 | 10.00 | 386 | 238460 | 175365 | 63074811 |
Liver injury | 67.25 | 10.00 | 77 | 238769 | 60443 | 63189733 |
Renal impairment | 66.35 | 10.00 | 146 | 238700 | 88209 | 63161967 |
Lymphocytic oesophagitis | 66.25 | 10.00 | 17 | 238829 | 17 | 63250159 |
Pneumonia | 64.80 | 10.00 | 1270 | 237576 | 455497 | 62794679 |
Intervertebral discitis | 64.77 | 10.00 | 70 | 238776 | 3158 | 63247018 |
Intentional self-injury | 64.39 | 10.00 | 228 | 238618 | 25459 | 63224717 |
Vision blurred | 64.31 | 10.00 | 577 | 238269 | 91347 | 63158829 |
Mania | 64.11 | 10.00 | 143 | 238703 | 12224 | 63237952 |
Sleep apnoea syndrome | 63.34 | 10.00 | 247 | 238599 | 28886 | 63221290 |
Leukopenia | 62.00 | 10.00 | 123 | 238723 | 77167 | 63173009 |
Mobility decreased | 61.96 | 10.00 | 240 | 238606 | 120919 | 63129257 |
Fibromyalgia | 61.06 | 10.00 | 514 | 238332 | 79906 | 63170270 |
Pulmonary malformation | 59.94 | 10.00 | 27 | 238819 | 272 | 63249904 |
Mucosal inflammation | 59.80 | 10.00 | 53 | 238793 | 46875 | 63203301 |
Sepsis | 59.58 | 10.00 | 335 | 238511 | 152788 | 63097388 |
Hyperreflexia | 59.21 | 10.00 | 91 | 238755 | 5843 | 63244333 |
Alanine aminotransferase increased | 59.17 | 10.00 | 624 | 238222 | 103146 | 63147030 |
Mental disorder | 59.02 | 10.00 | 223 | 238623 | 25696 | 63224480 |
Hallucination, visual | 58.81 | 10.00 | 183 | 238663 | 19115 | 63231061 |
Pleural effusion | 58.37 | 10.00 | 169 | 238677 | 93041 | 63157135 |
Haemoglobin decreased | 57.85 | 10.00 | 316 | 238530 | 145169 | 63105007 |
Colitis microscopic | 57.70 | 10.00 | 116 | 238730 | 9223 | 63240953 |
Sopor | 57.52 | 10.00 | 199 | 238647 | 21965 | 63228211 |
Blood creatinine increased | 57.43 | 10.00 | 156 | 238690 | 87688 | 63162488 |
Live birth | 57.39 | 10.00 | 13 | 238833 | 25617 | 63224559 |
Ascites | 56.89 | 10.00 | 42 | 238804 | 40686 | 63209490 |
Seizure | 56.39 | 10.00 | 754 | 238092 | 131880 | 63118296 |
White blood cell count decreased | 55.94 | 10.00 | 301 | 238545 | 138803 | 63111373 |
Red blood cell sedimentation rate abnormal | 55.93 | 10.00 | 5 | 238841 | 19777 | 63230399 |
Drug reaction with eosinophilia and systemic symptoms | 55.42 | 10.00 | 29 | 238817 | 33807 | 63216369 |
Paranoia | 54.98 | 10.00 | 130 | 238716 | 11549 | 63238627 |
Blood cholesterol increased | 54.95 | 10.00 | 176 | 238670 | 93856 | 63156320 |
Hot flush | 54.86 | 10.00 | 355 | 238491 | 50804 | 63199372 |
Product dose omission issue | 54.68 | 10.00 | 1209 | 237637 | 233104 | 63017072 |
Blood pressure increased | 53.89 | 10.00 | 883 | 237963 | 161179 | 63088997 |
Dyskinesia | 53.84 | 10.00 | 251 | 238595 | 31751 | 63218425 |
Surgery | 53.48 | 10.00 | 272 | 238574 | 35640 | 63214536 |
Cytomegalovirus infection | 52.53 | 10.00 | 8 | 238838 | 20944 | 63229232 |
Bronchial neoplasm | 52.21 | 10.00 | 29 | 238817 | 471 | 63249705 |
Amnesia | 51.45 | 10.00 | 372 | 238474 | 55213 | 63194963 |
Temperature intolerance | 51.44 | 10.00 | 108 | 238738 | 8856 | 63241320 |
Neutropenic sepsis | 49.77 | 10.00 | 3 | 238843 | 16435 | 63233741 |
Urinary retention | 49.76 | 10.00 | 236 | 238610 | 30065 | 63220111 |
Interstitial lung disease | 49.24 | 10.00 | 99 | 238747 | 61809 | 63188367 |
Renal failure | 48.74 | 10.00 | 252 | 238594 | 117400 | 63132776 |
Hyperaesthesia | 48.28 | 10.00 | 108 | 238738 | 9250 | 63240926 |
Hyperkalaemia | 48.16 | 10.00 | 81 | 238765 | 54122 | 63196054 |
Bronchial haemorrhage | 47.66 | 10.00 | 29 | 238817 | 563 | 63249613 |
Lung cyst | 47.38 | 10.00 | 24 | 238822 | 320 | 63249856 |
Restlessness | 47.36 | 10.00 | 228 | 238618 | 29225 | 63220951 |
Extremity contracture | 47.26 | 10.00 | 39 | 238807 | 1246 | 63248930 |
Coma blister | 47.19 | 10.00 | 19 | 238827 | 141 | 63250035 |
Rheumatoid nodule | 46.76 | 10.00 | 5 | 238841 | 17150 | 63233026 |
Bone marrow failure | 46.66 | 10.00 | 26 | 238820 | 29264 | 63220912 |
Hypocalcaemia | 46.54 | 10.00 | 31 | 238815 | 31682 | 63218494 |
Oesophageal spasm | 46.36 | 10.00 | 58 | 238788 | 3065 | 63247111 |
Neck deformity | 46.11 | 10.00 | 48 | 238798 | 2073 | 63248103 |
Intentional product use issue | 44.39 | 10.00 | 290 | 238556 | 127602 | 63122574 |
Multiple organ dysfunction syndrome | 44.08 | 10.00 | 92 | 238754 | 56660 | 63193516 |
Psoriasis | 43.67 | 10.00 | 510 | 238336 | 86447 | 63163729 |
Condition aggravated | 43.53 | 10.00 | 1166 | 237680 | 401051 | 62849125 |
Balance disorder | 43.23 | 10.00 | 497 | 238349 | 83925 | 63166251 |
Drug tolerance decreased | 43.06 | 10.00 | 7 | 238839 | 17466 | 63232710 |
Macular degeneration | 42.81 | 10.00 | 19 | 238827 | 24357 | 63225819 |
Rubber sensitivity | 42.37 | 10.00 | 48 | 238798 | 2283 | 63247893 |
Atrial fibrillation | 42.27 | 10.00 | 261 | 238585 | 116375 | 63133801 |
Nervousness | 42.25 | 10.00 | 229 | 238617 | 30750 | 63219426 |
Muscle twitching | 42.14 | 10.00 | 166 | 238680 | 19502 | 63230674 |
Therapy interrupted | 41.65 | 10.00 | 236 | 238610 | 32219 | 63217957 |
Device expulsion | 41.50 | 10.00 | 42 | 238804 | 34880 | 63215296 |
Neck mass | 41.34 | 10.00 | 59 | 238787 | 3544 | 63246632 |
Endometrial ablation | 41.31 | 10.00 | 32 | 238814 | 932 | 63249244 |
Neurologic neglect syndrome | 41.14 | 10.00 | 51 | 238795 | 2670 | 63247506 |
Neoplasm progression | 40.84 | 10.00 | 46 | 238800 | 36382 | 63213794 |
Oedema peripheral | 40.82 | 10.00 | 486 | 238360 | 189025 | 63061151 |
Gastrointestinal haemorrhage | 40.72 | 10.00 | 162 | 238684 | 81014 | 63169162 |
Respiratory tract malformation | 40.52 | 10.00 | 18 | 238828 | 175 | 63250001 |
Pruritus | 40.37 | 10.00 | 1043 | 237803 | 360410 | 62889766 |
Carotid artery thrombosis | 40.06 | 10.00 | 51 | 238795 | 2743 | 63247433 |
Vomiting | 40.05 | 10.00 | 2527 | 236319 | 557090 | 62693086 |
Pre-existing condition improved | 39.06 | 10.00 | 92 | 238754 | 8152 | 63242024 |
Therapy cessation | 38.78 | 10.00 | 221 | 238625 | 30236 | 63219940 |
Lip dry | 38.57 | 10.00 | 6 | 238840 | 15464 | 63234712 |
Dissociation | 38.30 | 10.00 | 51 | 238795 | 2868 | 63247308 |
Aspartate aminotransferase increased | 37.86 | 10.00 | 512 | 238334 | 89765 | 63160411 |
Type 2 diabetes mellitus | 37.69 | 10.00 | 119 | 238727 | 63749 | 63186427 |
Disorientation | 37.65 | 10.00 | 266 | 238580 | 39186 | 63210990 |
Hypersomnia | 37.57 | 10.00 | 151 | 238695 | 17904 | 63232272 |
Concussion | 37.29 | 10.00 | 97 | 238749 | 9147 | 63241029 |
Tachyphrenia | 37.11 | 10.00 | 35 | 238811 | 1339 | 63248837 |
Rapid eye movements sleep abnormal | 37.09 | 10.00 | 16 | 238830 | 144 | 63250032 |
Skin haemorrhage | 36.77 | 10.00 | 102 | 238744 | 9992 | 63240184 |
Hostility | 36.52 | 10.00 | 40 | 238806 | 1832 | 63248344 |
Major depression | 36.39 | 10.00 | 88 | 238758 | 7930 | 63242246 |
Knee arthroplasty | 36.38 | 10.00 | 95 | 238751 | 54111 | 63196065 |
Therapy non-responder | 35.88 | 10.00 | 155 | 238691 | 75746 | 63174430 |
Metabolic surgery | 35.60 | 10.00 | 33 | 238813 | 1235 | 63248941 |
Complex regional pain syndrome | 35.35 | 10.00 | 44 | 238802 | 2313 | 63247863 |
Rebound nasal congestion | 34.96 | 10.00 | 10 | 238836 | 20 | 63250156 |
Blood calcium decreased | 34.76 | 10.00 | 29 | 238817 | 26422 | 63223754 |
Inflammation | 34.76 | 10.00 | 175 | 238671 | 82098 | 63168078 |
Death | 34.55 | 10.00 | 1109 | 237737 | 373272 | 62876904 |
Palmar-plantar erythrodysaesthesia syndrome | 34.45 | 10.00 | 22 | 238824 | 22993 | 63227183 |
Cardiac failure congestive | 34.45 | 10.00 | 205 | 238641 | 92228 | 63157948 |
Adverse event | 34.41 | 10.00 | 134 | 238712 | 67425 | 63182751 |
Lactic acidosis | 34.21 | 10.00 | 57 | 238789 | 38230 | 63211946 |
Morbid thoughts | 34.18 | 10.00 | 24 | 238822 | 599 | 63249577 |
Pulmonary oedema | 33.98 | 10.00 | 100 | 238746 | 54773 | 63195403 |
Libido increased | 33.94 | 10.00 | 33 | 238813 | 1312 | 63248864 |
Akathisia | 33.89 | 10.00 | 93 | 238753 | 9053 | 63241123 |
Speech disorder | 33.70 | 10.00 | 265 | 238581 | 40364 | 63209812 |
Bruxism | 33.69 | 10.00 | 53 | 238793 | 3472 | 63246704 |
Bipolar disorder | 33.63 | 10.00 | 85 | 238761 | 7875 | 63242301 |
Formication | 33.61 | 10.00 | 59 | 238787 | 4232 | 63245944 |
Neuralgia | 33.58 | 10.00 | 189 | 238657 | 25737 | 63224439 |
Product use in unapproved indication | 33.49 | 10.00 | 473 | 238373 | 178607 | 63071569 |
Anovulatory cycle | 33.14 | 10.00 | 15 | 238831 | 153 | 63250023 |
Impaired driving ability | 32.75 | 10.00 | 60 | 238786 | 4451 | 63245725 |
Sacroiliitis | 32.57 | 10.00 | 50 | 238796 | 3207 | 63246969 |
Head injury | 31.79 | 10.00 | 194 | 238652 | 27202 | 63222974 |
Post cholecystectomy syndrome | 31.53 | 10.00 | 20 | 238826 | 419 | 63249757 |
Drug abuse | 31.53 | 10.00 | 414 | 238432 | 72104 | 63178072 |
Hypomagnesaemia | 31.45 | 10.00 | 37 | 238809 | 28700 | 63221476 |
Dysphagia | 31.43 | 10.00 | 488 | 238358 | 88097 | 63162079 |
Stiff person syndrome | 31.27 | 10.00 | 18 | 238828 | 314 | 63249862 |
Tearfulness | 31.25 | 10.00 | 56 | 238790 | 4083 | 63246093 |
Dry mouth | 31.18 | 10.00 | 438 | 238408 | 77425 | 63172751 |
Decompression sickness | 31.15 | 10.00 | 12 | 238834 | 78 | 63250098 |
Libido decreased | 31.02 | 10.00 | 44 | 238802 | 2628 | 63247548 |
Rash maculo-papular | 30.87 | 10.00 | 45 | 238801 | 31851 | 63218325 |
C-reactive protein increased | 30.75 | 10.00 | 219 | 238627 | 94488 | 63155688 |
Adjustment disorder | 30.68 | 10.00 | 48 | 238798 | 3130 | 63247046 |
Hypoventilation | 30.51 | 10.00 | 60 | 238786 | 4694 | 63245482 |
Hypnopompic hallucination | 30.47 | 10.00 | 11 | 238835 | 58 | 63250118 |
Delusion | 30.40 | 10.00 | 107 | 238739 | 11910 | 63238266 |
Anorgasmia | 30.25 | 10.00 | 22 | 238824 | 581 | 63249595 |
Respiratory failure | 30.01 | 10.00 | 242 | 238604 | 101616 | 63148560 |
Product tampering | 29.92 | 10.00 | 19 | 238827 | 399 | 63249777 |
Transplant rejection | 29.75 | 10.00 | 3 | 238843 | 10777 | 63239399 |
Gastrooesophageal reflux disease | 29.54 | 10.00 | 515 | 238331 | 95124 | 63155052 |
Skin necrosis | 29.44 | 10.00 | 8 | 238838 | 13942 | 63236234 |
Demyelination | 29.35 | 10.00 | 74 | 238772 | 6846 | 63243330 |
Melaena | 29.23 | 10.00 | 43 | 238803 | 30322 | 63219854 |
Psychotic disorder | 29.16 | 10.00 | 181 | 238665 | 25531 | 63224645 |
Psychotic disorder due to a general medical condition | 28.80 | 10.00 | 16 | 238830 | 260 | 63249916 |
Thunderclap headache | 28.60 | 10.00 | 15 | 238831 | 216 | 63249960 |
Intentional overdose | 28.44 | 10.00 | 414 | 238432 | 73738 | 63176438 |
Bone density abnormal | 28.29 | 10.00 | 48 | 238798 | 3350 | 63246826 |
Oedema | 28.27 | 10.00 | 233 | 238613 | 97389 | 63152787 |
Sensitivity to weather change | 28.23 | 10.00 | 75 | 238771 | 7162 | 63243014 |
Middle insomnia | 28.14 | 10.00 | 108 | 238738 | 12535 | 63237641 |
Phagophobia | 27.98 | 10.00 | 10 | 238836 | 51 | 63250125 |
Telangiectasia congenital | 27.96 | 10.00 | 8 | 238838 | 16 | 63250160 |
Emotional disorder | 27.92 | 10.00 | 112 | 238734 | 13267 | 63236909 |
Psychomotor hyperactivity | 27.89 | 10.00 | 96 | 238750 | 10567 | 63239609 |
Agranulocytosis | 27.89 | 10.00 | 32 | 238814 | 25102 | 63225074 |
Gastric banding | 27.87 | 10.00 | 11 | 238835 | 77 | 63250099 |
Epistaxis | 27.79 | 10.00 | 160 | 238686 | 72565 | 63177611 |
Lung disorder | 27.71 | 10.00 | 130 | 238716 | 62131 | 63188045 |
Hypotension | 27.71 | 10.00 | 797 | 238049 | 271807 | 62978369 |
Bronchial disorder | 27.70 | 10.00 | 29 | 238817 | 1261 | 63248915 |
Acute myeloid leukaemia | 27.63 | 10.00 | 15 | 238831 | 17132 | 63233044 |
Pregnancy | 27.54 | 10.00 | 61 | 238785 | 36775 | 63213401 |
Pulmonary eosinophilia | 27.49 | 10.00 | 17 | 238829 | 340 | 63249836 |
Blood immunoglobulin A increased | 27.34 | 10.00 | 23 | 238823 | 755 | 63249421 |
Therapeutic response changed | 27.05 | 10.00 | 26 | 238820 | 1019 | 63249157 |
Loss of libido | 26.62 | 10.00 | 29 | 238817 | 1320 | 63248856 |
Depressive symptom | 26.61 | 10.00 | 52 | 238794 | 4050 | 63246126 |
Oesophageal pain | 26.58 | 10.00 | 49 | 238797 | 3652 | 63246524 |
Thrombotic microangiopathy | 26.55 | 10.00 | 4 | 238842 | 10557 | 63239619 |
Metastases to bone | 26.46 | 10.00 | 24 | 238822 | 20995 | 63229181 |
Apathy | 26.43 | 10.00 | 83 | 238763 | 8711 | 63241465 |
Arthralgia | 26.42 | 10.00 | 1817 | 237029 | 567893 | 62682283 |
Ankle fracture | 26.42 | 10.00 | 135 | 238711 | 17720 | 63232456 |
Ejection fraction decreased | 26.37 | 10.00 | 27 | 238819 | 22305 | 63227871 |
Muscular weakness | 26.23 | 10.00 | 624 | 238222 | 121729 | 63128447 |
Bradycardia | 25.93 | 10.00 | 165 | 238681 | 73062 | 63177114 |
Gastrostomy | 25.93 | 10.00 | 21 | 238825 | 653 | 63249523 |
Red blood cell sedimentation rate increased | 25.91 | 10.00 | 82 | 238764 | 43900 | 63206276 |
Autonomic dysreflexia | 25.88 | 10.00 | 16 | 238830 | 320 | 63249856 |
Decreased interest | 25.83 | 10.00 | 45 | 238801 | 3209 | 63246967 |
Mydriasis | 25.69 | 10.00 | 101 | 238745 | 11855 | 63238321 |
Tenosynovitis | 25.43 | 10.00 | 10 | 238836 | 13785 | 63236391 |
Joint noise | 25.30 | 10.00 | 53 | 238793 | 4339 | 63245837 |
Proteinuria | 25.15 | 10.00 | 21 | 238825 | 19124 | 63231052 |
Bone erosion | 25.09 | 10.00 | 18 | 238828 | 17699 | 63232477 |
Spinal operation | 24.80 | 10.00 | 78 | 238768 | 8193 | 63241983 |
Exposure during pregnancy | 24.62 | 10.00 | 424 | 238422 | 155123 | 63095053 |
Drug resistance | 24.59 | 10.00 | 30 | 238816 | 22903 | 63227273 |
Cognitive disorder | 24.41 | 10.00 | 319 | 238527 | 55496 | 63194680 |
Aspartate aminotransferase | 24.36 | 10.00 | 17 | 238829 | 420 | 63249756 |
Adulterated product | 24.34 | 10.00 | 14 | 238832 | 244 | 63249932 |
Peripheral venous disease | 24.28 | 10.00 | 14 | 238832 | 15463 | 63234713 |
Toxicity to various agents | 24.25 | 10.00 | 1150 | 237696 | 246100 | 63004076 |
Tension | 24.03 | 10.00 | 43 | 238803 | 3132 | 63247044 |
Genital pain | 23.87 | 10.00 | 17 | 238829 | 434 | 63249742 |
Galactorrhoea | 23.77 | 10.00 | 50 | 238796 | 4105 | 63246071 |
Gait disturbance | 23.63 | 10.00 | 877 | 237969 | 182301 | 63067875 |
Homicidal ideation | 23.59 | 10.00 | 31 | 238815 | 1721 | 63248455 |
Tubulointerstitial nephritis | 23.57 | 10.00 | 24 | 238822 | 19879 | 63230297 |
Weight increased | 23.49 | 10.00 | 1203 | 237643 | 259589 | 62990587 |
Hallucination, auditory | 23.37 | 10.00 | 103 | 238743 | 12721 | 63237455 |
Flat affect | 23.26 | 10.00 | 28 | 238818 | 1422 | 63248754 |
Aplastic anaemia | 23.21 | 10.00 | 4 | 238842 | 9565 | 63240611 |
Antinuclear antibody negative | 22.88 | 10.00 | 13 | 238833 | 221 | 63249955 |
Depression suicidal | 22.62 | 10.00 | 31 | 238815 | 1792 | 63248384 |
Glomerular filtration rate increased | 22.60 | 10.00 | 22 | 238824 | 876 | 63249300 |
Haematotoxicity | 22.57 | 10.00 | 4 | 238842 | 9372 | 63240804 |
Creatinine renal clearance decreased | 22.54 | 10.00 | 17 | 238829 | 16291 | 63233885 |
Lupus-like syndrome | 22.38 | 10.00 | 15 | 238831 | 15280 | 63234896 |
Drug screen positive | 22.33 | 10.00 | 45 | 238801 | 3584 | 63246592 |
Metastases to liver | 22.25 | 10.00 | 34 | 238812 | 23605 | 63226571 |
Deep vein thrombosis | 22.06 | 10.00 | 205 | 238641 | 83595 | 63166581 |
Coombs positive haemolytic anaemia | 22.02 | 10.00 | 15 | 238831 | 356 | 63249820 |
Acute respiratory distress syndrome | 22.00 | 10.00 | 34 | 238812 | 23500 | 63226676 |
Poisoning | 21.98 | 10.00 | 106 | 238740 | 13594 | 63236582 |
Haemoptysis | 21.94 | 10.00 | 47 | 238799 | 28679 | 63221497 |
Hypercalcaemia | 21.92 | 10.00 | 46 | 238800 | 28276 | 63221900 |
Poor sucking reflex | 21.88 | 10.00 | 14 | 238832 | 298 | 63249878 |
Hepatotoxicity | 21.86 | 10.00 | 69 | 238777 | 36972 | 63213204 |
Toxic epidermal necrolysis | 21.47 | 10.00 | 39 | 238807 | 25295 | 63224881 |
Disseminated intravascular coagulation | 21.42 | 10.00 | 24 | 238822 | 19027 | 63231149 |
Granulomatous liver disease | 21.36 | 10.00 | 20 | 238826 | 758 | 63249418 |
Contusion | 21.25 | 10.00 | 417 | 238429 | 149627 | 63100549 |
Alcoholism | 21.20 | 10.00 | 30 | 238816 | 1788 | 63248388 |
Exposure via breast milk | 21.17 | 10.00 | 32 | 238814 | 2025 | 63248151 |
Blood alkaline phosphatase increased | 21.12 | 10.00 | 251 | 238595 | 42716 | 63207460 |
Dehydration | 21.00 | 10.00 | 494 | 238352 | 172860 | 63077316 |
Cerebral infarction | 20.95 | 10.00 | 36 | 238810 | 23857 | 63226319 |
Sinus disorder | 20.83 | 10.00 | 161 | 238685 | 24392 | 63225784 |
Pulmonary toxicity | 20.76 | 10.00 | 5 | 238841 | 9450 | 63240726 |
Muscle spasms | 20.72 | 10.00 | 750 | 238096 | 155400 | 63094776 |
Pulmonary congestion | 20.63 | 10.00 | 21 | 238825 | 17397 | 63232779 |
Facet joint syndrome | 20.48 | 10.00 | 10 | 238836 | 12128 | 63238048 |
Conversion disorder | 20.41 | 10.00 | 29 | 238817 | 1735 | 63248441 |
Basal cell carcinoma | 20.40 | 10.00 | 47 | 238799 | 27944 | 63222232 |
Clonus | 20.10 | 10.00 | 50 | 238796 | 4586 | 63245590 |
Myelodysplastic syndrome | 20.08 | 10.00 | 20 | 238826 | 16734 | 63233442 |
Shock | 19.99 | 10.00 | 36 | 238810 | 23427 | 63226749 |
Spinal disorder | 19.96 | 10.00 | 82 | 238764 | 9820 | 63240356 |
Arteriosclerosis coronary artery | 19.86 | 10.00 | 73 | 238773 | 8300 | 63241876 |
Overdose | 19.76 | 10.00 | 570 | 238276 | 114508 | 63135668 |
Cytokine release syndrome | 19.68 | 10.00 | 15 | 238831 | 14299 | 63235877 |
Sedation complication | 19.63 | 10.00 | 14 | 238832 | 13808 | 63236368 |
Poor quality sleep | 19.36 | 10.00 | 135 | 238711 | 19800 | 63230376 |
Coronary artery disease | 19.33 | 10.00 | 60 | 238786 | 32317 | 63217859 |
Intervertebral disc protrusion | 19.31 | 10.00 | 154 | 238692 | 23555 | 63226621 |
Bradyphrenia | 19.28 | 10.00 | 64 | 238782 | 6916 | 63243260 |
Asphyxia | 19.19 | 10.00 | 59 | 238787 | 6122 | 63244054 |
Hepatic enzyme increased | 19.19 | 10.00 | 597 | 238249 | 201731 | 63048445 |
Hyperacusis | 19.14 | 10.00 | 31 | 238815 | 2082 | 63248094 |
Granulocyte count increased | 19.13 | 10.00 | 20 | 238826 | 868 | 63249308 |
Tic | 19.09 | 10.00 | 26 | 238820 | 1494 | 63248682 |
Lactation disorder | 19.05 | 10.00 | 14 | 238832 | 376 | 63249800 |
Urinary incontinence | 18.93 | 10.00 | 194 | 238652 | 31820 | 63218356 |
Myoclonus | 18.81 | 10.00 | 113 | 238733 | 15755 | 63234421 |
Cystitis | 18.77 | 10.00 | 301 | 238545 | 54690 | 63195486 |
Dysphemia | 18.69 | 10.00 | 35 | 238811 | 2640 | 63247536 |
Premature labour | 18.65 | 10.00 | 12 | 238834 | 12492 | 63237684 |
Carcinoid tumour pulmonary | 18.62 | 10.00 | 15 | 238831 | 463 | 63249713 |
Injury | 18.50 | 10.00 | 181 | 238665 | 73066 | 63177110 |
Breast cancer stage II | 18.45 | 10.00 | 5 | 238841 | 8731 | 63241445 |
Circulatory collapse | 18.38 | 10.00 | 34 | 238812 | 21904 | 63228272 |
Dyspnoea exertional | 18.35 | 10.00 | 142 | 238704 | 60160 | 63190016 |
Feelings of worthlessness | 18.29 | 10.00 | 13 | 238833 | 331 | 63249845 |
Bacteraemia | 18.28 | 10.00 | 23 | 238823 | 17325 | 63232851 |
Pneumocystis jirovecii pneumonia | 18.27 | 10.00 | 22 | 238824 | 16892 | 63233284 |
Feeling of despair | 18.11 | 10.00 | 32 | 238814 | 2307 | 63247869 |
Pustular psoriasis | 18.10 | 10.00 | 48 | 238798 | 4578 | 63245598 |
Nasopharyngitis | 18.08 | 10.00 | 777 | 238069 | 253480 | 62996696 |
Hypoalbuminaemia | 18.06 | 10.00 | 11 | 238835 | 11794 | 63238382 |
Dactylitis | 18.03 | 10.00 | 34 | 238812 | 2578 | 63247598 |
Ophthalmic vein thrombosis | 18.01 | 10.00 | 11 | 238835 | 215 | 63249961 |
Drug eruption | 17.97 | 10.00 | 52 | 238794 | 28642 | 63221534 |
Right ventricular failure | 17.89 | 10.00 | 23 | 238823 | 17165 | 63233011 |
Panic disorder | 17.84 | 10.00 | 34 | 238812 | 2599 | 63247577 |
CYP3A4 polymorphism | 17.81 | 10.00 | 8 | 238838 | 80 | 63250096 |
Progressive multifocal leukoencephalopathy | 17.76 | 10.00 | 96 | 238750 | 12875 | 63237301 |
Sinus congestion | 17.76 | 10.00 | 123 | 238723 | 18000 | 63232176 |
Eosinophilia | 17.58 | 10.00 | 37 | 238809 | 22719 | 63227457 |
Respiratory distress | 17.51 | 10.00 | 67 | 238779 | 33884 | 63216292 |
Liver function test increased | 17.41 | 10.00 | 64 | 238782 | 32747 | 63217429 |
Impulse-control disorder | 17.39 | 10.00 | 18 | 238828 | 772 | 63249404 |
Bipolar I disorder | 17.39 | 10.00 | 28 | 238818 | 1871 | 63248305 |
Haemodialysis | 17.31 | 10.00 | 6 | 238840 | 8941 | 63241235 |
Cholestasis | 17.25 | 10.00 | 55 | 238791 | 29379 | 63220797 |
Sleep talking | 17.24 | 10.00 | 20 | 238826 | 976 | 63249200 |
Dopamine transporter scintigraphy abnormal | 17.22 | 10.00 | 8 | 238838 | 87 | 63250089 |
Rhonchi | 17.13 | 10.00 | 33 | 238813 | 2543 | 63247633 |
Toxic skin eruption | 17.09 | 10.00 | 14 | 238832 | 12871 | 63237305 |
Priapism | 17.07 | 10.00 | 9 | 238837 | 131 | 63250045 |
Panic reaction | 17.04 | 10.00 | 44 | 238802 | 4130 | 63246046 |
Claustrophobia | 16.89 | 10.00 | 20 | 238826 | 998 | 63249178 |
Vitamin B12 increased | 16.83 | 10.00 | 21 | 238825 | 1107 | 63249069 |
Hyponatraemic encephalopathy | 16.75 | 10.00 | 11 | 238835 | 245 | 63249931 |
Hypokalaemia | 16.73 | 10.00 | 282 | 238564 | 103522 | 63146654 |
Cardiogenic shock | 16.67 | 10.00 | 26 | 238820 | 17906 | 63232270 |
Pulseless electrical activity | 16.47 | 10.00 | 4 | 238842 | 7517 | 63242659 |
Metastases to central nervous system | 16.46 | 10.00 | 15 | 238831 | 13090 | 63237086 |
Scoliosis | 16.44 | 10.00 | 66 | 238780 | 7822 | 63242354 |
Aspergillus infection | 16.42 | 10.00 | 5 | 238841 | 8088 | 63242088 |
Tuberculosis | 16.39 | 10.00 | 11 | 238835 | 11200 | 63238976 |
Adjustment disorder with depressed mood | 16.34 | 10.00 | 9 | 238837 | 10195 | 63239981 |
Feeling drunk | 16.23 | 10.00 | 43 | 238803 | 4099 | 63246077 |
Autonomic nervous system imbalance | 16.23 | 10.00 | 34 | 238812 | 2784 | 63247392 |
Transfusion | 16.22 | 10.00 | 20 | 238826 | 15197 | 63234979 |
Oliguria | 16.13 | 10.00 | 7 | 238839 | 9094 | 63241082 |
Diplopia | 16.10 | 10.00 | 148 | 238698 | 23580 | 63226596 |
Fear | 16.04 | 10.00 | 108 | 238738 | 15658 | 63234518 |
Second primary malignancy | 15.98 | 10.00 | 5 | 238841 | 7948 | 63242228 |
Aphasia | 15.88 | 10.00 | 192 | 238654 | 32808 | 63217368 |
Oesophageal food impaction | 15.87 | 10.00 | 10 | 238836 | 207 | 63249969 |
Obsessive thoughts | 15.86 | 10.00 | 15 | 238831 | 576 | 63249600 |
Hypoxia | 15.85 | 10.00 | 146 | 238700 | 59646 | 63190530 |
Ischaemic stroke | 15.80 | 10.00 | 27 | 238819 | 17930 | 63232246 |
Rectal haemorrhage | 15.61 | 10.00 | 114 | 238732 | 48916 | 63201260 |
Post-traumatic neck syndrome | 15.58 | 10.00 | 28 | 238818 | 2046 | 63248130 |
Metastases to lung | 15.53 | 10.00 | 15 | 238831 | 12735 | 63237441 |
Intrusive thoughts | 15.42 | 10.00 | 10 | 238836 | 218 | 63249958 |
Pneumonitis | 15.40 | 10.00 | 74 | 238772 | 35148 | 63215028 |
Bronchiectasis | 15.40 | 10.00 | 23 | 238823 | 16119 | 63234057 |
Hypoaesthesia | 15.40 | 10.00 | 778 | 238068 | 167615 | 63082561 |
Decreased appetite | 15.29 | 10.00 | 780 | 238066 | 250272 | 62999904 |
Mean cell haemoglobin concentration increased | 15.26 | 10.00 | 14 | 238832 | 517 | 63249659 |
Rheumatoid factor increased | 15.24 | 10.00 | 26 | 238820 | 1823 | 63248353 |
Self-injurious ideation | 15.22 | 10.00 | 32 | 238814 | 2627 | 63247549 |
Meralgia paraesthetica | 15.17 | 10.00 | 13 | 238833 | 438 | 63249738 |
Blood lactate dehydrogenase increased | 15.14 | 10.00 | 41 | 238805 | 23075 | 63227101 |
Gambling disorder | 15.10 | 10.00 | 21 | 238825 | 1231 | 63248945 |
Cataplexy | 15.05 | 10.00 | 21 | 238825 | 1235 | 63248941 |
Naevus flammeus | 15.02 | 10.00 | 8 | 238838 | 119 | 63250057 |
Total cholesterol/HDL ratio abnormal | 15.00 | 10.00 | 7 | 238839 | 77 | 63250099 |
Hepatic steatosis | 15 | 10.00 | 170 | 238676 | 28599 | 63221577 |
Scar | 14.99 | 10.00 | 96 | 238750 | 13686 | 63236490 |
Drug hypersensitivity | 14.93 | 10.00 | 1360 | 237486 | 309327 | 62940849 |
Food aversion | 14.83 | 10.00 | 17 | 238829 | 819 | 63249357 |
Wound infection | 14.77 | 10.00 | 37 | 238809 | 21373 | 63228803 |
Liver disorder | 14.71 | 10.00 | 130 | 238716 | 53557 | 63196619 |
Hypervolaemia | 14.69 | 10.00 | 56 | 238790 | 28357 | 63221819 |
Eating disorder | 14.67 | 10.00 | 122 | 238724 | 18894 | 63231282 |
Impatience | 14.66 | 10.00 | 12 | 238834 | 379 | 63249797 |
Respiratory tract congestion | 14.62 | 10.00 | 116 | 238730 | 17716 | 63232460 |
Somnambulism | 14.58 | 10.00 | 50 | 238796 | 5493 | 63244683 |
Vasculitis | 14.58 | 10.00 | 29 | 238817 | 18180 | 63231996 |
Myofascial pain syndrome | 14.57 | 10.00 | 29 | 238817 | 2289 | 63247887 |
Heart rate decreased | 14.47 | 10.00 | 106 | 238740 | 45454 | 63204722 |
Mental impairment | 14.44 | 10.00 | 97 | 238749 | 14054 | 63236122 |
Anaphylactic reaction | 14.41 | 10.00 | 169 | 238677 | 65931 | 63184245 |
Cushingoid | 14.30 | 10.00 | 7 | 238839 | 8478 | 63241698 |
Tumour lysis syndrome | 14.29 | 10.00 | 8 | 238838 | 8982 | 63241194 |
Rales | 14.27 | 10.00 | 16 | 238830 | 12681 | 63237495 |
Device related infection | 14.21 | 10.00 | 43 | 238803 | 23349 | 63226827 |
Accidental exposure to product | 14.18 | 10.00 | 54 | 238792 | 27351 | 63222825 |
Hypnagogic hallucination | 14.13 | 10.00 | 9 | 238837 | 190 | 63249986 |
Hypoglycaemia | 14.11 | 10.00 | 151 | 238695 | 59914 | 63190262 |
Vitamin B12 deficiency | 14.09 | 10.00 | 48 | 238798 | 5255 | 63244921 |
Spondyloarthropathy | 14.02 | 10.00 | 17 | 238829 | 870 | 63249306 |
Hyperglycaemia | 13.98 | 10.00 | 96 | 238750 | 41771 | 63208405 |
Enterococcal infection | 13.97 | 10.00 | 6 | 238840 | 7842 | 63242334 |
Deformity | 13.94 | 10.00 | 14 | 238832 | 11670 | 63238506 |
Pseudomonas infection | 13.88 | 10.00 | 13 | 238833 | 11200 | 63238976 |
Lung diffusion test decreased | 13.77 | 10.00 | 15 | 238831 | 683 | 63249493 |
Clitoral engorgement | 13.76 | 10.00 | 3 | 238843 | 0 | 63250176 |
Phobia of driving | 13.76 | 10.00 | 3 | 238843 | 0 | 63250176 |
Tachyphylaxis | 13.69 | 10.00 | 10 | 238836 | 266 | 63249910 |
Heat exhaustion | 13.68 | 10.00 | 8 | 238838 | 144 | 63250032 |
Maternal exposure during breast feeding | 13.65 | 10.00 | 41 | 238805 | 4200 | 63245976 |
Motor dysfunction | 13.64 | 10.00 | 78 | 238768 | 10683 | 63239493 |
Drug-induced liver injury | 13.55 | 10.00 | 92 | 238754 | 40130 | 63210046 |
Rotator cuff syndrome | 13.45 | 10.00 | 92 | 238754 | 13410 | 63236766 |
Hepatobiliary scan abnormal | 13.45 | 10.00 | 6 | 238840 | 59 | 63250117 |
Gun shot wound | 13.44 | 10.00 | 8 | 238838 | 149 | 63250027 |
Metastases to lymph nodes | 13.35 | 10.00 | 7 | 238839 | 8151 | 63242025 |
Intentional dose omission | 13.33 | 10.00 | 63 | 238783 | 8012 | 63242164 |
Leukopenia neonatal | 13.32 | 10.00 | 5 | 238841 | 30 | 63250146 |
Holmes-Adie pupil | 13.32 | 10.00 | 5 | 238841 | 30 | 63250146 |
Soft tissue injury | 13.31 | 10.00 | 23 | 238823 | 1629 | 63248547 |
Trigeminal neuralgia | 13.25 | 10.00 | 36 | 238810 | 3483 | 63246693 |
Hepatitis C antibody positive | 13.21 | 10.00 | 7 | 238839 | 103 | 63250073 |
Dysarthria | 13.18 | 10.00 | 230 | 238616 | 42481 | 63207695 |
Immobilisation prolonged | 13.15 | 10.00 | 7 | 238839 | 104 | 63250072 |
Generalised anxiety disorder | 13.10 | 10.00 | 26 | 238820 | 2048 | 63248128 |
Progressive multiple sclerosis | 13.09 | 10.00 | 19 | 238827 | 1159 | 63249017 |
Sleep-related eating disorder | 12.95 | 10.00 | 16 | 238830 | 835 | 63249341 |
Palpitations | 12.91 | 10.00 | 533 | 238313 | 112237 | 63137939 |
Caesarean section | 12.90 | 10.00 | 28 | 238818 | 17004 | 63233172 |
Pathogen resistance | 12.89 | 10.00 | 4 | 238842 | 6394 | 63243782 |
Drug metabolising enzyme decreased | 12.85 | 10.00 | 4 | 238842 | 12 | 63250164 |
Sensory loss | 12.84 | 10.00 | 74 | 238772 | 10164 | 63240012 |
Radiation fibrosis | 12.79 | 10.00 | 5 | 238841 | 34 | 63250142 |
Torsade de pointes | 12.76 | 10.00 | 19 | 238827 | 13332 | 63236844 |
Sternal fracture | 12.75 | 10.00 | 27 | 238819 | 2227 | 63247949 |
Intervertebral disc operation | 12.71 | 10.00 | 16 | 238830 | 851 | 63249325 |
Breast cancer stage I | 12.69 | 10.00 | 5 | 238841 | 6884 | 63243292 |
Gastric ulcer | 12.68 | 10.00 | 47 | 238799 | 23990 | 63226186 |
Pulmonary arterial hypertension | 12.67 | 10.00 | 43 | 238803 | 22534 | 63227642 |
Acute myocardial infarction | 12.63 | 10.00 | 70 | 238776 | 32054 | 63218122 |
Anaphylactic shock | 12.60 | 10.00 | 46 | 238800 | 23587 | 63226589 |
Drug ineffective for unapproved indication | 12.60 | 10.00 | 189 | 238657 | 33874 | 63216302 |
Abdominal pain | 12.57 | 10.00 | 942 | 237904 | 292514 | 62957662 |
Musculoskeletal stiffness | 12.53 | 10.00 | 567 | 238279 | 184051 | 63066125 |
Foot deformity | 12.48 | 10.00 | 58 | 238788 | 27795 | 63222381 |
Food craving | 12.47 | 10.00 | 22 | 238824 | 1584 | 63248592 |
Ear pain | 12.47 | 10.00 | 82 | 238764 | 36036 | 63214140 |
Device difficult to use | 12.43 | 10.00 | 18 | 238828 | 12778 | 63237398 |
Autoimmune disorder | 12.39 | 10.00 | 29 | 238817 | 17148 | 63233028 |
Urinary hesitation | 12.38 | 10.00 | 27 | 238819 | 2273 | 63247903 |
Cytomegalovirus viraemia | 12.38 | 10.00 | 3 | 238843 | 5646 | 63244530 |
Breast cancer female | 12.29 | 10.00 | 20 | 238826 | 13539 | 63236637 |
Polyarthritis | 12.29 | 10.00 | 12 | 238834 | 10134 | 63240042 |
Menopausal symptoms | 12.25 | 10.00 | 28 | 238818 | 2433 | 63247743 |
Eye pain | 12.19 | 10.00 | 187 | 238659 | 33667 | 63216509 |
Foetal death | 12.16 | 10.00 | 14 | 238832 | 10966 | 63239210 |
Suspected suicide | 12.16 | 10.00 | 53 | 238793 | 6515 | 63243661 |
Nephrotic syndrome | 12.14 | 10.00 | 3 | 238843 | 5573 | 63244603 |
Adverse drug reaction | 12.06 | 10.00 | 219 | 238627 | 79495 | 63170681 |
Snoring | 12.03 | 10.00 | 39 | 238807 | 4163 | 63246013 |
Atelectasis | 12.00 | 10.00 | 41 | 238805 | 21442 | 63228734 |
Pulmonary haemorrhage | 11.99 | 10.00 | 6 | 238840 | 7175 | 63243001 |
Spasmodic dysphonia | 11.98 | 10.00 | 6 | 238840 | 78 | 63250098 |
Sinus pain | 11.97 | 10.00 | 34 | 238812 | 3376 | 63246800 |
Pulmonary hypertension | 11.97 | 10.00 | 86 | 238760 | 37037 | 63213139 |
Bone density decreased | 11.93 | 10.00 | 23 | 238823 | 14589 | 63235587 |
Polyneuropathy | 11.88 | 10.00 | 23 | 238823 | 14566 | 63235610 |
Haematuria | 11.76 | 10.00 | 63 | 238783 | 29094 | 63221082 |
Vitamin D deficiency | 11.73 | 10.00 | 91 | 238755 | 13801 | 63236375 |
Sluggishness | 11.72 | 10.00 | 45 | 238801 | 5224 | 63244952 |
Proctitis | 11.71 | 10.00 | 3 | 238843 | 5438 | 63244738 |
Chronic idiopathic pain syndrome | 11.69 | 10.00 | 3 | 238843 | 3 | 63250173 |
Intestinal intraepithelial lymphocytes increased | 11.69 | 10.00 | 3 | 238843 | 3 | 63250173 |
Increased appetite | 11.69 | 10.00 | 69 | 238777 | 9561 | 63240615 |
Sciatic nerve injury | 11.65 | 10.00 | 12 | 238834 | 512 | 63249664 |
Shock haemorrhagic | 11.64 | 10.00 | 12 | 238834 | 9883 | 63240293 |
Epstein-Barr virus infection | 11.64 | 10.00 | 8 | 238838 | 8042 | 63242134 |
Neuropathy peripheral | 11.62 | 10.00 | 531 | 238315 | 113136 | 63137040 |
Respiratory tract infection | 11.56 | 10.00 | 100 | 238746 | 41383 | 63208793 |
Metabolic acidosis | 11.54 | 10.00 | 111 | 238735 | 44958 | 63205218 |
Supraventricular tachyarrhythmia | 11.53 | 10.00 | 6 | 238840 | 85 | 63250091 |
Knee operation | 11.50 | 10.00 | 49 | 238797 | 5964 | 63244212 |
Polyglandular autoimmune syndrome type II | 11.49 | 10.00 | 5 | 238841 | 46 | 63250130 |
Serum serotonin increased | 11.49 | 10.00 | 8 | 238838 | 197 | 63249979 |
Economic problem | 11.48 | 10.00 | 24 | 238822 | 1962 | 63248214 |
Uraemic encephalopathy | 11.45 | 10.00 | 9 | 238837 | 268 | 63249908 |
Labelled drug-food interaction issue | 11.42 | 10.00 | 4 | 238842 | 19 | 63250157 |
Impulsive behaviour | 11.42 | 10.00 | 21 | 238825 | 1562 | 63248614 |
Abortion induced | 11.41 | 10.00 | 13 | 238833 | 10229 | 63239947 |
Cardiotoxicity | 11.40 | 10.00 | 9 | 238837 | 8429 | 63241747 |
Dystonia | 11.38 | 10.00 | 90 | 238756 | 13729 | 63236447 |
Escherichia infection | 11.38 | 10.00 | 19 | 238827 | 12735 | 63237441 |
Suspected suicide attempt | 11.37 | 10.00 | 7 | 238839 | 139 | 63250037 |
Alcohol abuse | 11.33 | 10.00 | 25 | 238821 | 2121 | 63248055 |
Retching | 11.32 | 10.00 | 94 | 238752 | 14551 | 63235625 |
Purple glove syndrome | 11.21 | 10.00 | 8 | 238838 | 205 | 63249971 |
Persistent genital arousal disorder | 11.19 | 10.00 | 9 | 238837 | 277 | 63249899 |
Posterior reversible encephalopathy syndrome | 11.18 | 10.00 | 31 | 238815 | 17314 | 63232862 |
Phonophobia | 11.16 | 10.00 | 10 | 238836 | 358 | 63249818 |
Genital ulceration | 11.09 | 10.00 | 13 | 238833 | 642 | 63249534 |
Skin plaque | 11.08 | 10.00 | 9 | 238837 | 8311 | 63241865 |
Pyometra | 11.05 | 10.00 | 6 | 238840 | 93 | 63250083 |
Alveolar bone resorption | 11.05 | 10.00 | 5 | 238841 | 51 | 63250125 |
Ventricular hypoplasia | 11.02 | 10.00 | 7 | 238839 | 147 | 63250029 |
Osteonecrosis of jaw | 11.02 | 10.00 | 82 | 238764 | 35041 | 63215135 |
Neck pain | 10.99 | 10.00 | 340 | 238506 | 68978 | 63181198 |
Suicidal behaviour | 10.96 | 10.00 | 28 | 238818 | 2611 | 63247565 |
Reaction to azo-dyes | 10.94 | 10.00 | 4 | 238842 | 22 | 63250154 |
Trigger finger | 10.94 | 10.00 | 39 | 238807 | 4369 | 63245807 |
Drug screen negative | 10.92 | 10.00 | 9 | 238837 | 287 | 63249889 |
Feeling jittery | 10.88 | 10.00 | 87 | 238759 | 13316 | 63236860 |
Accommodation disorder | 10.86 | 10.00 | 10 | 238836 | 371 | 63249805 |
Herpes simplex reactivation | 10.84 | 10.00 | 12 | 238834 | 556 | 63249620 |
Multiple-drug resistance | 10.84 | 10.00 | 3 | 238843 | 5167 | 63245009 |
Suspected product quality issue | 10.82 | 10.00 | 8 | 238838 | 217 | 63249959 |
Hemiplegia | 10.80 | 10.00 | 66 | 238780 | 9257 | 63240919 |
Pulse abnormal | 10.79 | 10.00 | 26 | 238820 | 2338 | 63247838 |
Antiphospholipid syndrome | 10.78 | 10.00 | 22 | 238824 | 1768 | 63248408 |
Status epilepticus | 10.76 | 10.00 | 26 | 238820 | 15207 | 63234969 |
Drug withdrawal syndrome neonatal | 10.72 | 10.00 | 24 | 238822 | 2057 | 63248119 |
Electric shock sensation | 10.70 | 10.00 | 14 | 238832 | 774 | 63249402 |
Forced expiratory volume decreased | 10.70 | 10.00 | 42 | 238804 | 4926 | 63245250 |
Acute pulmonary oedema | 10.65 | 10.00 | 9 | 238837 | 8149 | 63242027 |
Ligament injury | 10.62 | 10.00 | 17 | 238829 | 1130 | 63249046 |
Lung neoplasm malignant | 10.61 | 10.00 | 38 | 238808 | 19595 | 63230581 |
Occipital neuralgia | 10.59 | 10.00 | 11 | 238835 | 474 | 63249702 |
Unintended pregnancy | 10.56 | 10.00 | 5 | 238841 | 6174 | 63244002 |
Klebsiella infection | 10.53 | 10.00 | 10 | 238836 | 8556 | 63241620 |
Clumsiness | 10.52 | 10.00 | 24 | 238822 | 2083 | 63248093 |
Rheumatoid arthritis | 10.51 | 10.00 | 817 | 238029 | 253002 | 62997174 |
Hepatitis A antibody positive | 10.48 | 10.00 | 5 | 238841 | 58 | 63250118 |
Adiposis dolorosa | 10.48 | 10.00 | 9 | 238837 | 304 | 63249872 |
Congenital tricuspid valve atresia | 10.46 | 10.00 | 6 | 238840 | 104 | 63250072 |
Foot amputation | 10.46 | 10.00 | 9 | 238837 | 305 | 63249871 |
Antidepressant drug level increased | 10.41 | 10.00 | 9 | 238837 | 307 | 63249869 |
Borderline personality disorder | 10.38 | 10.00 | 14 | 238832 | 797 | 63249379 |
Hydronephrosis | 10.36 | 10.00 | 15 | 238831 | 10647 | 63239529 |
Central nervous system lesion | 10.32 | 10.00 | 72 | 238774 | 10563 | 63239613 |
Violence-related symptom | 10.28 | 10.00 | 10 | 238836 | 398 | 63249778 |
Fractured coccyx | 10.23 | 10.00 | 16 | 238830 | 1043 | 63249133 |
Cough | 10.22 | 10.00 | 955 | 237891 | 291788 | 62958388 |
Colitis | 10.22 | 10.00 | 125 | 238721 | 48403 | 63201773 |
Haemorrhage intracranial | 10.21 | 10.00 | 22 | 238824 | 13397 | 63236779 |
Cardiac murmur | 10.15 | 10.00 | 25 | 238821 | 14527 | 63235649 |
Burning mouth syndrome | 10.11 | 10.00 | 11 | 238835 | 500 | 63249676 |
Dysgraphia | 10.09 | 10.00 | 31 | 238815 | 3215 | 63246961 |
Haemolytic anaemia | 10.08 | 10.00 | 14 | 238832 | 10111 | 63240065 |
Tongue movement disturbance | 10.05 | 10.00 | 9 | 238837 | 322 | 63249854 |
Sickle cell anaemia with crisis | 10.05 | 10.00 | 5 | 238841 | 5998 | 63244178 |
Anuria | 10.04 | 10.00 | 20 | 238826 | 12531 | 63237645 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 1270.43 | 11.19 | 691 | 75471 | 19143 | 34861626 |
Dysphoria | 1218.65 | 11.19 | 368 | 75794 | 1934 | 34878835 |
Affect lability | 1145.29 | 11.19 | 393 | 75769 | 3290 | 34877479 |
Suicidal ideation | 772.19 | 11.19 | 666 | 75496 | 39722 | 34841047 |
Irritability | 649.80 | 11.19 | 491 | 75671 | 24199 | 34856570 |
Sensory disturbance | 553.58 | 11.19 | 270 | 75892 | 5907 | 34874862 |
Agitation | 470.59 | 11.19 | 602 | 75560 | 56797 | 34823972 |
Vertigo | 467.37 | 11.19 | 411 | 75751 | 25125 | 34855644 |
Paraesthesia | 452.27 | 11.19 | 625 | 75537 | 63547 | 34817222 |
Insomnia | 435.92 | 11.19 | 798 | 75364 | 103109 | 34777660 |
Hyperhidrosis | 427.42 | 11.19 | 664 | 75498 | 75028 | 34805741 |
Nightmare | 407.10 | 11.19 | 299 | 75863 | 14092 | 34866677 |
Anxiety | 367.91 | 11.19 | 724 | 75438 | 98704 | 34782065 |
Serotonin syndrome | 278.19 | 11.19 | 276 | 75886 | 19657 | 34861112 |
Completed suicide | 267.78 | 11.19 | 632 | 75530 | 97536 | 34783233 |
Dizziness | 242.19 | 11.19 | 1029 | 75133 | 217492 | 34663277 |
Hypomania | 241.43 | 11.19 | 113 | 76049 | 2246 | 34878523 |
Tremor | 233.13 | 11.19 | 539 | 75623 | 82048 | 34798721 |
Confusional state | 226.08 | 11.19 | 759 | 75403 | 143401 | 34737368 |
Mood swings | 216.29 | 11.19 | 161 | 76001 | 7740 | 34873029 |
Lethargy | 215.60 | 11.19 | 349 | 75813 | 40773 | 34839996 |
Tinnitus | 213.86 | 11.19 | 241 | 75921 | 19877 | 34860892 |
Headache | 174.86 | 11.19 | 881 | 75281 | 199754 | 34681015 |
Nausea | 161.25 | 11.19 | 1277 | 74885 | 338631 | 34542138 |
Febrile neutropenia | 147.23 | 11.19 | 57 | 76105 | 136792 | 34743977 |
Suicide attempt | 145.75 | 11.19 | 286 | 75876 | 38830 | 34841939 |
Pyrexia | 130.35 | 11.19 | 338 | 75824 | 332675 | 34548094 |
Sleep disorder | 120.85 | 11.19 | 234 | 75928 | 31454 | 34849315 |
Fatigue | 115.83 | 11.19 | 1274 | 74888 | 369379 | 34511390 |
Anger | 107.35 | 11.19 | 131 | 76031 | 11753 | 34869016 |
Thrombocytopenia | 106.50 | 11.19 | 110 | 76052 | 156137 | 34724632 |
Acute kidney injury | 105.67 | 11.19 | 328 | 75834 | 304660 | 34576109 |
Withdrawal syndrome | 102.44 | 11.19 | 131 | 76031 | 12324 | 34868445 |
Depression | 94.85 | 11.19 | 441 | 75721 | 96657 | 34784112 |
Sedation | 92.46 | 11.19 | 165 | 75997 | 20841 | 34859928 |
Anaemia | 91.76 | 11.19 | 236 | 75926 | 233099 | 34647670 |
Gastrointestinal tube insertion | 87.15 | 11.19 | 46 | 76116 | 1193 | 34879576 |
Somnolence | 77.04 | 11.19 | 459 | 75703 | 110657 | 34770112 |
Pancytopenia | 74.32 | 11.19 | 59 | 76103 | 95098 | 34785671 |
Disturbance in attention | 72.70 | 11.19 | 169 | 75993 | 25776 | 34854993 |
Feeling abnormal | 69.07 | 11.19 | 297 | 75865 | 62938 | 34817831 |
Fall | 68.96 | 11.19 | 710 | 75452 | 202175 | 34678594 |
Multiple organ dysfunction syndrome | 68.39 | 11.19 | 41 | 76121 | 76525 | 34804244 |
Intentional self-injury | 68.23 | 11.19 | 114 | 76048 | 13657 | 34867112 |
Sepsis | 64.23 | 11.19 | 170 | 75992 | 166391 | 34714378 |
Memory impairment | 60.67 | 11.19 | 220 | 75942 | 43098 | 34837671 |
Neutropenia | 59.69 | 11.19 | 161 | 76001 | 156617 | 34724152 |
Dyspnoea | 58.26 | 11.19 | 533 | 75629 | 376249 | 34504520 |
Disease progression | 55.28 | 11.19 | 94 | 76068 | 107983 | 34772786 |
Intentional overdose | 53.08 | 11.19 | 212 | 75950 | 43462 | 34837307 |
Antidepressant drug level above therapeutic | 52.93 | 11.19 | 20 | 76142 | 226 | 34880543 |
Haemoglobin decreased | 52.26 | 11.19 | 116 | 76046 | 120656 | 34760113 |
Affective disorder | 51.10 | 11.19 | 55 | 76107 | 4305 | 34876464 |
Pleural effusion | 50.48 | 11.19 | 62 | 76100 | 81484 | 34799285 |
Hallucination, auditory | 50.38 | 11.19 | 92 | 76070 | 11825 | 34868944 |
Toxicity to various agents | 50.11 | 11.19 | 661 | 75501 | 199701 | 34681068 |
Analgesic drug level above therapeutic | 48.26 | 11.19 | 20 | 76142 | 293 | 34880476 |
Sexual dysfunction | 48.25 | 11.19 | 64 | 76098 | 6239 | 34874530 |
Hepatic enzyme increased | 47.72 | 11.19 | 190 | 75972 | 38890 | 34841879 |
Malignant neoplasm progression | 47.43 | 11.19 | 74 | 76088 | 87972 | 34792797 |
Ascites | 47.43 | 11.19 | 21 | 76141 | 46550 | 34834219 |
Loss of consciousness | 47.08 | 11.19 | 325 | 75837 | 82342 | 34798427 |
Blood creatinine increased | 46.40 | 11.19 | 85 | 76077 | 94891 | 34785878 |
Reversible airways obstruction | 45.68 | 11.19 | 22 | 76140 | 467 | 34880302 |
Overdose | 44.98 | 11.19 | 346 | 75816 | 90713 | 34790056 |
Urinary retention | 44.77 | 11.19 | 177 | 75985 | 36111 | 34844658 |
Myoclonus | 42.43 | 11.19 | 97 | 76065 | 14628 | 34866141 |
Respiratory disorder neonatal | 41.91 | 11.19 | 32 | 76130 | 1598 | 34879171 |
Product used for unknown indication | 41.05 | 11.19 | 26 | 76136 | 957 | 34879812 |
Renal failure | 40.54 | 11.19 | 147 | 76015 | 130410 | 34750359 |
Pneumonia | 40.51 | 11.19 | 552 | 75610 | 362075 | 34518694 |
Delusion of grandeur | 39.49 | 11.19 | 27 | 76135 | 1133 | 34879636 |
General physical health deterioration | 39.44 | 11.19 | 145 | 76017 | 128124 | 34752645 |
Haemorrhage | 37.45 | 11.19 | 34 | 76128 | 51336 | 34829433 |
Respiratory failure | 37.28 | 11.19 | 117 | 76045 | 108455 | 34772314 |
C-reactive protein increased | 36.89 | 11.19 | 38 | 76124 | 54060 | 34826709 |
Road traffic accident | 36.71 | 11.19 | 102 | 76060 | 17348 | 34863421 |
Balance disorder | 36.27 | 11.19 | 180 | 75982 | 40474 | 34840295 |
Gastric bypass | 35.97 | 11.19 | 16 | 76146 | 281 | 34880488 |
Psychotic disorder | 35.77 | 11.19 | 126 | 76036 | 24326 | 34856443 |
Cardiac failure | 35.22 | 11.19 | 93 | 76069 | 91155 | 34789614 |
Platelet count decreased | 34.44 | 11.19 | 139 | 76023 | 119578 | 34761191 |
Aggression | 34.39 | 11.19 | 172 | 75990 | 38792 | 34841977 |
Migraine | 33.69 | 11.19 | 99 | 76063 | 17379 | 34863390 |
Cytomegalovirus infection | 33.26 | 11.19 | 8 | 76154 | 26127 | 34854642 |
Growth hormone deficiency | 32.94 | 11.19 | 15 | 76147 | 279 | 34880490 |
Metabolic acidosis | 32.94 | 11.19 | 28 | 76134 | 43652 | 34837117 |
Feeling jittery | 32.75 | 11.19 | 42 | 76120 | 3961 | 34876808 |
Bradyphrenia | 32.62 | 11.19 | 46 | 76116 | 4752 | 34876017 |
Rhinalgia | 32.31 | 11.19 | 23 | 76139 | 1030 | 34879739 |
Self esteem decreased | 32.31 | 11.19 | 18 | 76144 | 521 | 34880248 |
Product use in unapproved indication | 31.59 | 11.19 | 140 | 76022 | 117359 | 34763410 |
Abnormal dreams | 31.40 | 11.19 | 58 | 76104 | 7520 | 34873249 |
Renal impairment | 30.95 | 11.19 | 104 | 76058 | 94409 | 34786360 |
Urinary hesitation | 30.50 | 11.19 | 34 | 76128 | 2768 | 34878001 |
Therapy interrupted | 29.74 | 11.19 | 81 | 76081 | 13616 | 34867153 |
Drug resistance | 29.19 | 11.19 | 10 | 76152 | 25917 | 34854852 |
Disorientation | 28.93 | 11.19 | 146 | 76016 | 33042 | 34847727 |
Mania | 28.91 | 11.19 | 64 | 76098 | 9447 | 34871322 |
Hypokalaemia | 28.51 | 11.19 | 52 | 76110 | 58162 | 34822607 |
Pain | 28.17 | 11.19 | 613 | 75549 | 204062 | 34676707 |
Surgery | 28.07 | 11.19 | 81 | 76081 | 14076 | 34866693 |
Hallucination | 27.86 | 11.19 | 200 | 75962 | 51298 | 34829471 |
Neuropathy peripheral | 27.53 | 11.19 | 290 | 75872 | 82973 | 34797796 |
Agranulocytosis | 27.14 | 11.19 | 9 | 76153 | 23812 | 34856957 |
Disseminated intravascular coagulation | 27.13 | 11.19 | 7 | 76155 | 21809 | 34858960 |
Yawning | 26.88 | 11.19 | 16 | 76146 | 526 | 34880243 |
Gait disturbance | 26.51 | 11.19 | 293 | 75869 | 84847 | 34795922 |
Off label use | 26.26 | 11.19 | 705 | 75457 | 418819 | 34461950 |
Bone marrow failure | 25.64 | 11.19 | 16 | 76146 | 29237 | 34851532 |
White blood cell count decreased | 25.48 | 11.19 | 114 | 76048 | 95331 | 34785438 |
Cytokine release syndrome | 25.45 | 11.19 | 9 | 76153 | 22868 | 34857901 |
Post concussion syndrome | 25.14 | 11.19 | 10 | 76152 | 131 | 34880638 |
Dehydration | 25.00 | 11.19 | 173 | 75989 | 129796 | 34750973 |
Septic shock | 24.93 | 11.19 | 77 | 76085 | 71757 | 34809012 |
Electric shock sensation | 24.87 | 11.19 | 10 | 76152 | 135 | 34880634 |
Nephrolithiasis | 24.75 | 11.19 | 131 | 76031 | 30202 | 34850567 |
Fibromyalgia | 24.54 | 11.19 | 32 | 76130 | 3068 | 34877701 |
Initial insomnia | 24.34 | 11.19 | 32 | 76130 | 3092 | 34877677 |
Major depression | 24.20 | 11.19 | 39 | 76123 | 4533 | 34876236 |
Seizure | 23.33 | 11.19 | 339 | 75823 | 104518 | 34776251 |
Amnesia | 23.25 | 11.19 | 117 | 76045 | 26446 | 34854323 |
Hypocalcaemia | 23.12 | 11.19 | 12 | 76150 | 24277 | 34856492 |
Depressed mood | 22.84 | 11.19 | 93 | 76069 | 19224 | 34861545 |
Abnormal behaviour | 22.58 | 11.19 | 111 | 76051 | 24858 | 34855911 |
Atrial fibrillation | 22.52 | 11.19 | 165 | 75997 | 122228 | 34758541 |
Haematochezia | 22.40 | 11.19 | 42 | 76120 | 46492 | 34834277 |
Cough | 22.39 | 11.19 | 214 | 75948 | 149926 | 34730843 |
Drug hypersensitivity | 22.33 | 11.19 | 271 | 75891 | 80258 | 34800511 |
Hepatitis E antibody positive | 21.92 | 11.19 | 11 | 76151 | 256 | 34880513 |
Convulsive threshold lowered | 21.90 | 11.19 | 14 | 76148 | 524 | 34880245 |
Homicidal ideation | 21.72 | 11.19 | 28 | 76134 | 2654 | 34878115 |
Hypertensive emergency | 21.57 | 11.19 | 18 | 76144 | 1022 | 34879747 |
Pneumocystis jirovecii pneumonia | 21.51 | 11.19 | 8 | 76154 | 19702 | 34861067 |
Dystonia | 21.45 | 11.19 | 62 | 76100 | 10783 | 34869986 |
Oedema peripheral | 21.34 | 11.19 | 163 | 75999 | 119649 | 34761120 |
Haemoptysis | 21.25 | 11.19 | 27 | 76135 | 34979 | 34845790 |
Interstitial lung disease | 21.25 | 11.19 | 72 | 76090 | 65210 | 34815559 |
Complex regional pain syndrome | 21.22 | 11.19 | 14 | 76148 | 553 | 34880216 |
International normalised ratio increased | 20.82 | 11.19 | 45 | 76117 | 47282 | 34833487 |
Agitation neonatal | 20.75 | 11.19 | 18 | 76144 | 1078 | 34879691 |
Hepatitis E virus test positive | 20.74 | 11.19 | 11 | 76151 | 288 | 34880481 |
Thinking abnormal | 20.61 | 11.19 | 43 | 76119 | 6094 | 34874675 |
Rash maculo-papular | 20.53 | 11.19 | 19 | 76143 | 28432 | 34852337 |
Rash | 20.38 | 11.19 | 352 | 75810 | 222400 | 34658369 |
Multiple sclerosis relapse | 20.36 | 11.19 | 69 | 76093 | 13064 | 34867705 |
Erectile dysfunction | 20.30 | 11.19 | 94 | 76068 | 20543 | 34860226 |
Erythema | 20.27 | 11.19 | 112 | 76050 | 88668 | 34792101 |
Somnambulism | 20.22 | 11.19 | 29 | 76133 | 3043 | 34877726 |
Toxic epidermal necrolysis | 20.16 | 11.19 | 11 | 76151 | 21635 | 34859134 |
Respiratory distress | 20.14 | 11.19 | 29 | 76133 | 35636 | 34845133 |
Neutropenic sepsis | 20.09 | 11.19 | 3 | 76159 | 13764 | 34867005 |
Myocardial infarction | 20.06 | 11.19 | 168 | 75994 | 120917 | 34759852 |
Delirium | 19.97 | 11.19 | 164 | 75998 | 43827 | 34836942 |
Hypersomnia | 19.96 | 11.19 | 66 | 76096 | 12341 | 34868428 |
Gastrointestinal adenocarcinoma | 19.84 | 11.19 | 7 | 76155 | 64 | 34880705 |
Undifferentiated connective tissue disease | 19.78 | 11.19 | 6 | 76156 | 32 | 34880737 |
Prostate cancer | 19.78 | 11.19 | 35 | 76127 | 39614 | 34841155 |
Neutrophil count decreased | 19.77 | 11.19 | 52 | 76110 | 51052 | 34829717 |
Acute stress disorder | 19.74 | 11.19 | 9 | 76153 | 168 | 34880601 |
Neuralgia | 19.68 | 11.19 | 75 | 76087 | 15038 | 34865731 |
Pneumonitis | 19.67 | 11.19 | 27 | 76135 | 33851 | 34846918 |
Pericardial effusion | 19.60 | 11.19 | 15 | 76147 | 24647 | 34856122 |
Blood lactate dehydrogenase increased | 19.56 | 11.19 | 13 | 76149 | 22977 | 34857792 |
Drug reaction with eosinophilia and systemic symptoms | 19.48 | 11.19 | 26 | 76136 | 32986 | 34847783 |
Muscle spasticity | 19.47 | 11.19 | 41 | 76121 | 5847 | 34874922 |
Mental disorder | 19.41 | 11.19 | 75 | 76087 | 15134 | 34865635 |
Liver function test abnormal | 19.37 | 11.19 | 125 | 76037 | 30949 | 34849820 |
Drug interaction | 19.33 | 11.19 | 636 | 75526 | 225310 | 34655459 |
Lymphopenia | 18.91 | 11.19 | 6 | 76156 | 16329 | 34864440 |
Restless legs syndrome | 18.74 | 11.19 | 50 | 76112 | 8304 | 34872465 |
Angioedema | 18.64 | 11.19 | 33 | 76129 | 37341 | 34843428 |
Wrong drug | 18.61 | 11.19 | 7 | 76155 | 78 | 34880691 |
Pulmonary embolism | 18.49 | 11.19 | 117 | 76045 | 89629 | 34791140 |
Tumour lysis syndrome | 18.49 | 11.19 | 7 | 76155 | 17052 | 34863717 |
Productive cough | 18.31 | 11.19 | 34 | 76128 | 37779 | 34842990 |
Dysmetropsia | 18.29 | 11.19 | 4 | 76158 | 3 | 34880766 |
Clonus | 18.16 | 11.19 | 26 | 76136 | 2724 | 34878045 |
Sleep-related eating disorder | 18.15 | 11.19 | 10 | 76152 | 283 | 34880486 |
Intentional product use issue | 18.11 | 11.19 | 68 | 76094 | 59748 | 34821021 |
Inappropriate antidiuretic hormone secretion | 18.04 | 11.19 | 65 | 76097 | 12688 | 34868081 |
Lacunar stroke | 17.99 | 11.19 | 9 | 76153 | 208 | 34880561 |
Bezoar | 17.97 | 11.19 | 17 | 76145 | 1140 | 34879629 |
Drug screen false positive | 17.89 | 11.19 | 14 | 76148 | 725 | 34880044 |
Haematuria | 17.85 | 11.19 | 53 | 76109 | 50013 | 34830756 |
Dissociation | 17.84 | 11.19 | 20 | 76142 | 1638 | 34879131 |
Nephropathy toxic | 17.79 | 11.19 | 3 | 76159 | 12585 | 34868184 |
Sleep sex | 17.76 | 11.19 | 4 | 76158 | 4 | 34880765 |
Tubulointerstitial nephritis | 17.74 | 11.19 | 12 | 76150 | 21012 | 34859757 |
Bipolar disorder | 17.67 | 11.19 | 30 | 76132 | 3639 | 34877130 |
Compulsive shopping | 17.66 | 11.19 | 11 | 76151 | 393 | 34880376 |
Lymphocyte count abnormal | 17.47 | 11.19 | 17 | 76145 | 1181 | 34879588 |
Restlessness | 17.45 | 11.19 | 105 | 76057 | 25377 | 34855392 |
Acute myeloid leukaemia | 17.43 | 11.19 | 9 | 76153 | 18261 | 34862508 |
Feeling guilty | 17.24 | 11.19 | 10 | 76152 | 313 | 34880456 |
Steatohepatitis | 16.99 | 11.19 | 10 | 76152 | 322 | 34880447 |
Infusion related reaction | 16.94 | 11.19 | 59 | 76103 | 52998 | 34827771 |
Gastrointestinal haemorrhage | 16.89 | 11.19 | 118 | 76044 | 88359 | 34792410 |
Neonatal tachypnoea | 16.82 | 11.19 | 8 | 76154 | 165 | 34880604 |
Mucosal inflammation | 16.76 | 11.19 | 37 | 76125 | 38585 | 34842184 |
Cardiogenic shock | 16.71 | 11.19 | 20 | 76142 | 26598 | 34854171 |
Stomatitis | 16.65 | 11.19 | 43 | 76119 | 42471 | 34838298 |
Coronary artery disease | 16.60 | 11.19 | 52 | 76110 | 48253 | 34832516 |
Forced expiratory flow decreased | 16.56 | 11.19 | 8 | 76154 | 171 | 34880598 |
Tardive dyskinesia | 16.52 | 11.19 | 38 | 76124 | 5752 | 34875017 |
Paedophilia | 16.49 | 11.19 | 4 | 76158 | 7 | 34880762 |
Psychomotor hyperactivity | 16.21 | 11.19 | 52 | 76110 | 9570 | 34871199 |
Multiple sclerosis | 16.16 | 11.19 | 41 | 76121 | 6604 | 34874165 |
Dissociative disorder | 16.16 | 11.19 | 11 | 76151 | 458 | 34880311 |
Cholestasis | 16.13 | 11.19 | 21 | 76141 | 26927 | 34853842 |
Rhabdomyolysis | 16.11 | 11.19 | 85 | 76077 | 68078 | 34812691 |
Apathy | 16.06 | 11.19 | 42 | 76120 | 6890 | 34873879 |
Hallucination, visual | 16.02 | 11.19 | 79 | 76083 | 17712 | 34863057 |
Cardiac failure congestive | 15.92 | 11.19 | 111 | 76051 | 83159 | 34797610 |
Panic attack | 15.91 | 11.19 | 51 | 76111 | 9381 | 34871388 |
Loss of control of legs | 15.86 | 11.19 | 13 | 76149 | 720 | 34880049 |
Paranoia | 15.80 | 11.19 | 60 | 76102 | 12008 | 34868761 |
Ventricular fibrillation | 15.78 | 11.19 | 16 | 76146 | 22938 | 34857831 |
Schizophrenia | 15.67 | 11.19 | 48 | 76114 | 8618 | 34872151 |
Intentional product misuse | 15.60 | 11.19 | 160 | 76002 | 45451 | 34835318 |
Adenocarcinoma of appendix | 15.58 | 11.19 | 7 | 76155 | 126 | 34880643 |
Delirium tremens | 15.39 | 11.19 | 12 | 76150 | 618 | 34880151 |
Hyperlipasaemia | 15.39 | 11.19 | 11 | 76151 | 496 | 34880273 |
Alcoholism | 15.29 | 11.19 | 25 | 76137 | 2940 | 34877829 |
Orgasm abnormal | 15.29 | 11.19 | 7 | 76155 | 132 | 34880637 |
Abdominal pain | 15.13 | 11.19 | 258 | 75904 | 163360 | 34717409 |
Chest injury | 15.12 | 11.19 | 18 | 76144 | 1573 | 34879196 |
Ventricular hypoplasia | 15.05 | 11.19 | 6 | 76156 | 79 | 34880690 |
Palmar-plantar erythrodysaesthesia syndrome | 14.97 | 11.19 | 9 | 76153 | 16786 | 34863983 |
Drug screen positive | 14.88 | 11.19 | 29 | 76133 | 3914 | 34876855 |
Neonatal hyponatraemia | 14.85 | 11.19 | 6 | 76156 | 82 | 34880687 |
Cerebral infarction | 14.84 | 11.19 | 23 | 76139 | 27432 | 34853337 |
Urethral discharge | 14.77 | 11.19 | 4 | 76158 | 13 | 34880756 |
Narcissistic personality disorder | 14.77 | 11.19 | 4 | 76158 | 13 | 34880756 |
Libido decreased | 14.72 | 11.19 | 32 | 76130 | 4664 | 34876105 |
Hypoxia | 14.58 | 11.19 | 66 | 76096 | 55029 | 34825740 |
Dyskinesia | 14.49 | 11.19 | 91 | 76071 | 22322 | 34858447 |
Ileus | 14.49 | 11.19 | 9 | 76153 | 16490 | 34864279 |
Acute myocardial infarction | 14.43 | 11.19 | 64 | 76098 | 53655 | 34827114 |
Snoring | 14.35 | 11.19 | 26 | 76136 | 3320 | 34877449 |
Therapy cessation | 14.32 | 11.19 | 74 | 76088 | 16899 | 34863870 |
Speech sound disorder | 14.31 | 11.19 | 7 | 76155 | 154 | 34880615 |
Treatment failure | 14.19 | 11.19 | 53 | 76109 | 46644 | 34834125 |
Influenza like illness | 14.18 | 11.19 | 106 | 76056 | 27528 | 34853241 |
Norepinephrine increased | 14.12 | 11.19 | 4 | 76158 | 16 | 34880753 |
Blood urea increased | 14.09 | 11.19 | 28 | 76134 | 30336 | 34850433 |
Stiff person syndrome | 14.00 | 11.19 | 6 | 76156 | 96 | 34880673 |
Lymphoma | 13.78 | 11.19 | 5 | 76157 | 12502 | 34868267 |
Extrapyramidal disorder | 13.66 | 11.19 | 60 | 76102 | 12820 | 34867949 |
Tethered cord syndrome | 13.57 | 11.19 | 4 | 76158 | 19 | 34880750 |
Epistaxis | 13.56 | 11.19 | 73 | 76089 | 58178 | 34822591 |
Deep vein thrombosis | 13.47 | 11.19 | 85 | 76077 | 65163 | 34815606 |
Hypotension | 13.41 | 11.19 | 374 | 75788 | 221275 | 34659494 |
Renal aplasia | 13.34 | 11.19 | 12 | 76150 | 754 | 34880015 |
Psychopathic personality | 13.32 | 11.19 | 3 | 76159 | 3 | 34880766 |
Ureteric haemorrhage | 13.26 | 11.19 | 6 | 76156 | 110 | 34880659 |
Axillary pain | 13.24 | 11.19 | 9 | 76153 | 374 | 34880395 |
Prescribed overdose | 13.18 | 11.19 | 52 | 76110 | 10595 | 34870174 |
Respiratory depression | 13.14 | 11.19 | 70 | 76092 | 16175 | 34864594 |
Orthostatic hypotension | 13.06 | 11.19 | 99 | 76063 | 25820 | 34854949 |
Loss of employment | 13.00 | 11.19 | 10 | 76152 | 505 | 34880264 |
Homicide | 12.97 | 11.19 | 13 | 76149 | 936 | 34879833 |
Colitis | 12.72 | 11.19 | 41 | 76121 | 37709 | 34843060 |
Suicidal behaviour | 12.71 | 11.19 | 16 | 76146 | 1481 | 34879288 |
Death | 12.68 | 11.19 | 724 | 75438 | 397325 | 34483444 |
Cyanosis | 12.61 | 11.19 | 6 | 76156 | 12758 | 34868011 |
Lymphadenopathy | 12.57 | 11.19 | 27 | 76135 | 28436 | 34852333 |
Aplastic anaemia | 12.31 | 11.19 | 3 | 76159 | 9713 | 34871056 |
Chills | 12.29 | 11.19 | 115 | 76047 | 80928 | 34799841 |
Retrograde ejaculation | 12.24 | 11.19 | 9 | 76153 | 424 | 34880345 |
Pre-existing condition improved | 12.23 | 11.19 | 21 | 76141 | 2571 | 34878198 |
Melaena | 12.22 | 11.19 | 38 | 76124 | 35342 | 34845427 |
Lung disorder | 12.17 | 11.19 | 37 | 76125 | 34659 | 34846110 |
Helplessness | 12.14 | 11.19 | 5 | 76157 | 72 | 34880697 |
Infection | 12.13 | 11.19 | 133 | 76029 | 90782 | 34789987 |
Hypomagnesaemia | 12.11 | 11.19 | 18 | 76144 | 21833 | 34858936 |
Slow speech | 12.09 | 11.19 | 14 | 76148 | 1188 | 34879581 |
Graft versus host disease | 12.03 | 11.19 | 4 | 76158 | 10565 | 34870204 |
Selective eating disorder | 12.02 | 11.19 | 17 | 76145 | 1761 | 34879008 |
Mitral valve incompetence | 11.99 | 11.19 | 9 | 76153 | 14934 | 34865835 |
Facial spasm | 11.99 | 11.19 | 7 | 76155 | 222 | 34880547 |
Brief psychotic disorder with marked stressors | 11.93 | 11.19 | 7 | 76155 | 224 | 34880545 |
Acute hepatic failure | 11.92 | 11.19 | 8 | 76154 | 14066 | 34866703 |
Leukopenia | 11.91 | 11.19 | 84 | 76078 | 62772 | 34817997 |
Autonomic dysreflexia | 11.90 | 11.19 | 5 | 76157 | 76 | 34880693 |
Hyperglycaemia | 11.87 | 11.19 | 45 | 76117 | 39435 | 34841334 |
Device related infection | 11.87 | 11.19 | 12 | 76150 | 17225 | 34863544 |
Drug tolerance | 11.87 | 11.19 | 22 | 76140 | 2860 | 34877909 |
Product administration interrupted | 11.75 | 11.19 | 17 | 76145 | 1798 | 34878971 |
Depersonalisation/derealisation disorder | 11.74 | 11.19 | 10 | 76152 | 584 | 34880185 |
Morbid thoughts | 11.74 | 11.19 | 7 | 76155 | 231 | 34880538 |
Peritonitis | 11.72 | 11.19 | 11 | 76151 | 16354 | 34864415 |
Abulia | 11.65 | 11.19 | 10 | 76152 | 590 | 34880179 |
Reflexes abnormal | 11.65 | 11.19 | 8 | 76154 | 338 | 34880431 |
Dementia | 11.64 | 11.19 | 60 | 76102 | 13688 | 34867081 |
Blue toe syndrome | 11.64 | 11.19 | 6 | 76156 | 148 | 34880621 |
Panic disorder | 11.61 | 11.19 | 14 | 76148 | 1240 | 34879529 |
Hyperreflexia | 11.40 | 11.19 | 23 | 76139 | 3183 | 34877586 |
Lung infiltration | 11.39 | 11.19 | 7 | 76155 | 12898 | 34867871 |
Pulmonary fibrosis | 11.36 | 11.19 | 14 | 76148 | 18382 | 34862387 |
Mood altered | 11.31 | 11.19 | 44 | 76118 | 8908 | 34871861 |
Hepatic cytolysis | 11.29 | 11.19 | 9 | 76153 | 14487 | 34866282 |
Hyperbilirubinaemia | 11.29 | 11.19 | 12 | 76150 | 16831 | 34863938 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug withdrawal syndrome | 980.01 | 9.93 | 798 | 222573 | 33920 | 79487097 |
Suicidal ideation | 861.96 | 9.93 | 1066 | 222305 | 75274 | 79445743 |
Serotonin syndrome | 838.52 | 9.93 | 818 | 222553 | 44209 | 79476808 |
Completed suicide | 569.92 | 9.93 | 1746 | 221625 | 244021 | 79276996 |
Hyperhidrosis | 489.93 | 9.93 | 1216 | 222155 | 150276 | 79370741 |
Dysphoria | 474.18 | 9.93 | 242 | 223129 | 4492 | 79516525 |
Affect lability | 402.98 | 9.93 | 298 | 223073 | 10961 | 79510056 |
Irritability | 361.16 | 9.93 | 508 | 222863 | 40636 | 79480381 |
Tremor | 352.41 | 9.93 | 1163 | 222208 | 168920 | 79352097 |
Anxiety | 346.06 | 9.93 | 1496 | 221875 | 247016 | 79274001 |
Nightmare | 345.95 | 9.93 | 394 | 222977 | 25467 | 79495550 |
Febrile neutropenia | 325.48 | 9.93 | 120 | 223251 | 230879 | 79290138 |
Agitation | 301.94 | 9.93 | 781 | 222590 | 98934 | 79422083 |
Suicide attempt | 269.25 | 9.93 | 667 | 222704 | 82265 | 79438752 |
Depression | 262.08 | 9.93 | 1252 | 222119 | 215538 | 79305479 |
Stubbornness | 259.32 | 9.93 | 79 | 223292 | 316 | 79520701 |
Pemphigus | 258.13 | 9.93 | 4 | 223367 | 99578 | 79421439 |
Feeling abnormal | 256.65 | 9.93 | 1003 | 222368 | 158196 | 79362821 |
Insomnia | 256.34 | 9.93 | 1359 | 222012 | 243811 | 79277206 |
Somnolence | 242.55 | 9.93 | 1314 | 222057 | 237667 | 79283350 |
Thrombocytopenia | 238.08 | 9.93 | 235 | 223136 | 265024 | 79255993 |
Withdrawal syndrome | 237.78 | 9.93 | 333 | 223038 | 26521 | 79494496 |
Dizziness | 216.35 | 9.93 | 2339 | 221032 | 524102 | 78996915 |
Pyrexia | 215.93 | 9.93 | 1073 | 222298 | 677636 | 78843381 |
Mood swings | 210.46 | 9.93 | 269 | 223102 | 19611 | 79501406 |
Sensory disturbance | 200.45 | 9.93 | 229 | 223142 | 14848 | 79506169 |
Fall | 200.02 | 9.93 | 2166 | 221205 | 485463 | 79035554 |
Neutropenia | 198.37 | 9.93 | 312 | 223059 | 287398 | 79233619 |
Vertigo | 195.76 | 9.93 | 528 | 222843 | 68554 | 79452463 |
Anaemia | 191.61 | 9.93 | 624 | 222747 | 444391 | 79076626 |
Pericarditis | 187.18 | 9.93 | 33 | 223338 | 104203 | 79416814 |
Pancytopenia | 178.15 | 9.93 | 123 | 223248 | 165622 | 79355395 |
Glossodynia | 176.49 | 9.93 | 37 | 223334 | 103300 | 79417717 |
Hand deformity | 175.86 | 9.93 | 38 | 223333 | 103881 | 79417136 |
Acute kidney injury | 173.22 | 9.93 | 807 | 222564 | 518597 | 79002420 |
Paraesthesia | 172.41 | 9.93 | 960 | 222411 | 175363 | 79345654 |
Headache | 171.54 | 9.93 | 2675 | 220696 | 651097 | 78869920 |
Mood altered | 169.57 | 9.93 | 229 | 223142 | 17618 | 79503399 |
Duodenal ulcer perforation | 162.47 | 9.93 | 5 | 223366 | 66206 | 79454811 |
Thinking abnormal | 150.34 | 9.93 | 185 | 223186 | 12976 | 79508041 |
Nausea | 149.35 | 9.93 | 3618 | 219753 | 953578 | 78567439 |
Synovitis | 147.72 | 9.93 | 123 | 223248 | 150611 | 79370406 |
Affective disorder | 145.25 | 9.93 | 146 | 223225 | 8173 | 79512844 |
Disturbance in attention | 142.63 | 9.93 | 387 | 222984 | 50414 | 79470603 |
Intentional self-injury | 141.13 | 9.93 | 293 | 223078 | 32126 | 79488891 |
Crying | 141.12 | 9.93 | 241 | 223130 | 22802 | 79498215 |
Contraindicated product administered | 139.61 | 9.93 | 141 | 223230 | 157397 | 79363620 |
Confusional state | 135.96 | 9.93 | 1425 | 221946 | 316572 | 79204445 |
Anger | 134.68 | 9.93 | 201 | 223170 | 16961 | 79504056 |
Migraine | 133.46 | 9.93 | 542 | 222829 | 86951 | 79434066 |
Inappropriate antidiuretic hormone secretion | 127.90 | 9.93 | 249 | 223122 | 26064 | 79494953 |
Loss of consciousness | 120.07 | 9.93 | 844 | 222527 | 167099 | 79353918 |
Memory impairment | 119.77 | 9.93 | 624 | 222747 | 111110 | 79409907 |
Depressed mood | 118.22 | 9.93 | 351 | 223020 | 48129 | 79472888 |
Drug interaction | 116.00 | 9.93 | 1718 | 221653 | 413465 | 79107552 |
General physical health deterioration | 113.47 | 9.93 | 393 | 222978 | 274845 | 79246172 |
Electric shock | 113.34 | 9.93 | 62 | 223309 | 1332 | 79519685 |
Folliculitis | 112.46 | 9.93 | 12 | 223359 | 55368 | 79465649 |
Toxicity to various agents | 111.46 | 9.93 | 1728 | 221643 | 419812 | 79101205 |
C-reactive protein abnormal | 110.82 | 9.93 | 6 | 223365 | 48361 | 79472656 |
Malignant neoplasm progression | 108.11 | 9.93 | 133 | 223238 | 135857 | 79385160 |
Abnormal behaviour | 107.84 | 9.93 | 283 | 223088 | 36138 | 79484879 |
Anti-cyclic citrullinated peptide antibody positive | 107.59 | 9.93 | 49 | 223322 | 83094 | 79437923 |
Disease progression | 107.19 | 9.93 | 222 | 223149 | 184140 | 79336877 |
Tinnitus | 107.17 | 9.93 | 320 | 223051 | 44013 | 79477004 |
Multiple sclerosis relapse | 106.98 | 9.93 | 330 | 223041 | 46203 | 79474814 |
Sepsis | 106.87 | 9.93 | 391 | 222980 | 269037 | 79251980 |
Product substitution issue | 105.00 | 9.93 | 197 | 223174 | 20059 | 79500958 |
Coordination abnormal | 104.61 | 9.93 | 180 | 223191 | 17132 | 79503885 |
Platelet count decreased | 104.47 | 9.93 | 245 | 223126 | 194419 | 79326598 |
Somatic symptom disorder | 104.17 | 9.93 | 73 | 223298 | 2464 | 79518553 |
Multiple sclerosis | 103.64 | 9.93 | 207 | 223164 | 22075 | 79498942 |
Systemic lupus erythematosus | 103.31 | 9.93 | 112 | 223259 | 121037 | 79399980 |
Cardiac failure | 101.87 | 9.93 | 173 | 223198 | 154669 | 79366348 |
Wound | 98.41 | 9.93 | 108 | 223263 | 116071 | 79404946 |
Sleep disorder due to general medical condition, insomnia type | 97.96 | 9.93 | 6 | 223365 | 43550 | 79477467 |
Multiple organ dysfunction syndrome | 95.16 | 9.93 | 118 | 223253 | 120128 | 79400889 |
Myelosuppression | 92.32 | 9.93 | 5 | 223366 | 40291 | 79480726 |
Tardive dyskinesia | 91.96 | 9.93 | 130 | 223241 | 10441 | 79510576 |
Fibromyalgia | 91.38 | 9.93 | 390 | 222981 | 63950 | 79457067 |
Off label use | 91.12 | 9.93 | 1895 | 221476 | 905320 | 78615697 |
Post-traumatic stress disorder | 89.54 | 9.93 | 88 | 223283 | 4793 | 79516224 |
Infusion related reaction | 88.11 | 9.93 | 339 | 223032 | 229898 | 79291119 |
Muscle injury | 87.99 | 9.93 | 15 | 223356 | 48546 | 79472471 |
Treatment failure | 87.19 | 9.93 | 220 | 223151 | 170266 | 79350751 |
Ascites | 86.72 | 9.93 | 52 | 223319 | 75510 | 79445507 |
Septic shock | 85.65 | 9.93 | 132 | 223239 | 122669 | 79398348 |
Panic attack | 85.21 | 9.93 | 201 | 223170 | 24015 | 79497002 |
Renal failure | 84.80 | 9.93 | 284 | 223087 | 200684 | 79320333 |
Reversible cerebral vasoconstriction syndrome | 83.55 | 9.93 | 69 | 223302 | 2988 | 79518029 |
Restless legs syndrome | 82.12 | 9.93 | 177 | 223194 | 19915 | 79501102 |
Hypomania | 81.30 | 9.93 | 103 | 223268 | 7441 | 79513576 |
Pain | 81.28 | 9.93 | 2561 | 220810 | 701241 | 78819776 |
Alopecia | 80.80 | 9.93 | 353 | 223018 | 231002 | 79290015 |
Intentional overdose | 80.73 | 9.93 | 541 | 222830 | 105419 | 79415598 |
Urinary retention | 80.22 | 9.93 | 343 | 223028 | 56287 | 79464730 |
Coma | 79.17 | 9.93 | 518 | 222853 | 100131 | 79420886 |
Blood creatinine increased | 78.58 | 9.93 | 201 | 223170 | 154856 | 79366161 |
Renal impairment | 78.08 | 9.93 | 207 | 223164 | 157576 | 79363441 |
Surgery | 77.77 | 9.93 | 235 | 223136 | 32531 | 79488486 |
Personality disorder | 77.75 | 9.93 | 91 | 223280 | 6055 | 79514962 |
Therapy interrupted | 76.49 | 9.93 | 227 | 223144 | 31114 | 79489903 |
Discomfort | 74.06 | 9.93 | 150 | 223221 | 125467 | 79395550 |
Blister | 73.62 | 9.93 | 139 | 223232 | 119337 | 79401680 |
Hallucination | 73.45 | 9.93 | 451 | 222920 | 85294 | 79435723 |
Mental disorder | 72.89 | 9.93 | 223 | 223148 | 31079 | 79489938 |
Hyperreflexia | 72.76 | 9.93 | 103 | 223268 | 8282 | 79512735 |
Drug intolerance | 72.43 | 9.93 | 438 | 222933 | 263681 | 79257336 |
Pleural effusion | 72.31 | 9.93 | 190 | 223181 | 145072 | 79375945 |
Fatigue | 71.99 | 9.93 | 3236 | 220135 | 926491 | 78594526 |
Cytomegalovirus infection | 71.31 | 9.93 | 16 | 223355 | 42628 | 79478389 |
Rash | 70.71 | 9.93 | 1167 | 222204 | 577191 | 78943826 |
Helicobacter infection | 70.61 | 9.93 | 55 | 223316 | 69649 | 79451368 |
Balance disorder | 69.55 | 9.93 | 495 | 222876 | 98362 | 79422655 |
Hypersensitivity | 68.74 | 9.93 | 441 | 222930 | 261798 | 79259219 |
Lymphocytic oesophagitis | 68.49 | 9.93 | 17 | 223354 | 23 | 79520994 |
Nasal turbinate hypertrophy | 67.13 | 9.93 | 35 | 223336 | 680 | 79520337 |
Pneumonia aspiration | 66.97 | 9.93 | 367 | 223004 | 66600 | 79454417 |
Opsoclonus myoclonus | 66.90 | 9.93 | 25 | 223346 | 207 | 79520810 |
Therapy cessation | 66.50 | 9.93 | 244 | 223127 | 37318 | 79483699 |
Hallucination, visual | 66.05 | 9.93 | 222 | 223149 | 32507 | 79488510 |
Mania | 65.82 | 9.93 | 153 | 223218 | 18107 | 79502910 |
Arthropathy | 65.05 | 9.93 | 265 | 223106 | 176846 | 79344171 |
Sopor | 64.94 | 9.93 | 222 | 223149 | 32788 | 79488229 |
Oesophageal spasm | 64.69 | 9.93 | 63 | 223308 | 3393 | 79517624 |
Neutrophil count decreased | 64.56 | 9.93 | 102 | 223269 | 93857 | 79427160 |
Rheumatic fever | 63.94 | 9.93 | 4 | 223367 | 28521 | 79492496 |
Product dose omission issue | 63.88 | 9.93 | 1011 | 222360 | 246526 | 79274491 |
Colitis microscopic | 63.80 | 9.93 | 111 | 223260 | 10657 | 79510360 |
Drug reaction with eosinophilia and systemic symptoms | 63.43 | 9.93 | 52 | 223319 | 64192 | 79456825 |
Neutropenic sepsis | 63.13 | 9.93 | 3 | 223368 | 27061 | 79493956 |
Stomatitis | 62.85 | 9.93 | 206 | 223165 | 146551 | 79374466 |
Psoriasis | 62.68 | 9.93 | 448 | 222923 | 89139 | 79431878 |
Rheumatoid factor positive | 62.17 | 9.93 | 46 | 223325 | 59793 | 79461224 |
Hypocalcaemia | 62.17 | 9.93 | 31 | 223340 | 49893 | 79471124 |
Haemoglobin decreased | 61.60 | 9.93 | 367 | 223004 | 221752 | 79299265 |
Influenza like illness | 61.31 | 9.93 | 377 | 222994 | 71330 | 79449687 |
Swelling | 60.66 | 9.93 | 357 | 223014 | 216354 | 79304663 |
Vision blurred | 60.42 | 9.93 | 505 | 222866 | 105393 | 79415624 |
Blood pressure increased | 60.22 | 9.93 | 878 | 222493 | 210482 | 79310535 |
Bronchial neoplasm | 59.85 | 9.93 | 29 | 223342 | 479 | 79520538 |
Rubber sensitivity | 59.70 | 9.93 | 45 | 223326 | 1704 | 79519313 |
Joint swelling | 59.64 | 9.93 | 519 | 222852 | 288127 | 79232890 |
Gastric bypass | 59.48 | 9.93 | 40 | 223331 | 1261 | 79519756 |
Abnormal dreams | 59.16 | 9.93 | 111 | 223260 | 11301 | 79509716 |
Bone marrow failure | 58.88 | 9.93 | 35 | 223336 | 51072 | 79469945 |
Coma blister | 58.83 | 9.93 | 23 | 223348 | 218 | 79520799 |
Intervertebral discitis | 58.62 | 9.93 | 70 | 223301 | 4758 | 79516259 |
Lower respiratory tract infection | 58.41 | 9.93 | 177 | 223194 | 129043 | 79391974 |
Neck deformity | 57.73 | 9.93 | 45 | 223326 | 1792 | 79519225 |
Maternal exposure during pregnancy | 56.86 | 9.93 | 194 | 223177 | 136344 | 79384673 |
Atrial fibrillation | 55.91 | 9.93 | 325 | 223046 | 197561 | 79323456 |
Gastrointestinal tube insertion | 55.77 | 9.93 | 42 | 223329 | 1588 | 79519429 |
Drug hypersensitivity | 55.69 | 9.93 | 1160 | 222211 | 297756 | 79223261 |
Oedema peripheral | 55.56 | 9.93 | 446 | 222925 | 251842 | 79269175 |
Amnesia | 55.47 | 9.93 | 334 | 223037 | 62723 | 79458294 |
Erythema | 55.24 | 9.93 | 382 | 222989 | 222908 | 79298109 |
Hot flush | 55.04 | 9.93 | 301 | 223070 | 54576 | 79466441 |
Disorientation | 54.90 | 9.93 | 332 | 223039 | 62444 | 79458573 |
Mucosal inflammation | 54.87 | 9.93 | 79 | 223292 | 75501 | 79445516 |
Pneumonia | 54.65 | 9.93 | 1420 | 221951 | 658826 | 78862191 |
Lethargy | 54.27 | 9.93 | 402 | 222969 | 80890 | 79440127 |
Pulmonary malformation | 52.55 | 9.93 | 21 | 223350 | 212 | 79520805 |
Temperature intolerance | 52.32 | 9.93 | 96 | 223275 | 9609 | 79511408 |
Impaired healing | 52.24 | 9.93 | 104 | 223267 | 87551 | 79433466 |
Dyskinesia | 52.12 | 9.93 | 256 | 223115 | 44517 | 79476500 |
Endometrial ablation | 52.07 | 9.93 | 32 | 223339 | 861 | 79520156 |
Hallucination, auditory | 51.56 | 9.93 | 151 | 223220 | 20542 | 79500475 |
Extremity contracture | 51.36 | 9.93 | 41 | 223330 | 1691 | 79519326 |
Overdose | 51.21 | 9.93 | 762 | 222609 | 183444 | 79337573 |
Sedation | 50.94 | 9.93 | 283 | 223088 | 51612 | 79469405 |
Bradyphrenia | 50.87 | 9.93 | 100 | 223271 | 10540 | 79510477 |
Bronchopulmonary aspergillosis | 50.35 | 9.93 | 3 | 223368 | 22291 | 79498726 |
Pulmonary fibrosis | 49.72 | 9.93 | 31 | 223340 | 44081 | 79476936 |
Weight increased | 49.57 | 9.93 | 1070 | 222301 | 276316 | 79244701 |
Stiff person syndrome | 49.18 | 9.93 | 22 | 223349 | 300 | 79520717 |
Interstitial lung disease | 48.94 | 9.93 | 157 | 223214 | 112443 | 79408574 |
Neurologic neglect syndrome | 48.89 | 9.93 | 50 | 223321 | 2857 | 79518160 |
Dyspnoea | 48.88 | 9.93 | 1935 | 221436 | 855090 | 78665927 |
Carotid artery thrombosis | 48.63 | 9.93 | 51 | 223320 | 3002 | 79518015 |
White blood cell count decreased | 48.62 | 9.93 | 318 | 223053 | 187970 | 79333047 |
Respiratory failure | 48.53 | 9.93 | 302 | 223069 | 180609 | 79340408 |
Infection | 48.42 | 9.93 | 438 | 222933 | 241274 | 79279743 |
Libido increased | 48.20 | 9.93 | 42 | 223329 | 1959 | 79519058 |
Clonus | 47.89 | 9.93 | 76 | 223295 | 6764 | 79514253 |
Hyperaesthesia | 46.92 | 9.93 | 105 | 223266 | 12117 | 79508900 |
Dissociation | 46.69 | 9.93 | 57 | 223314 | 3964 | 79517053 |
Sleep apnoea syndrome | 46.41 | 9.93 | 214 | 223157 | 36264 | 79484753 |
Leukopenia | 46.20 | 9.93 | 169 | 223202 | 116344 | 79404673 |
Abdominal discomfort | 46.11 | 9.93 | 464 | 222907 | 250263 | 79270754 |
Lung cyst | 45.45 | 9.93 | 21 | 223350 | 310 | 79520707 |
Intentional product misuse | 44.17 | 9.93 | 434 | 222937 | 94731 | 79426286 |
Red blood cell sedimentation rate abnormal | 43.98 | 9.93 | 4 | 223367 | 20959 | 79500058 |
Self esteem decreased | 43.88 | 9.93 | 30 | 223341 | 972 | 79520045 |
Cytokine release syndrome | 43.85 | 9.93 | 23 | 223348 | 35975 | 79485042 |
Rash maculo-papular | 43.34 | 9.93 | 56 | 223315 | 56022 | 79464995 |
Restlessness | 43.30 | 9.93 | 250 | 223121 | 46242 | 79474775 |
Morbid thoughts | 42.38 | 9.93 | 27 | 223344 | 775 | 79520242 |
Irritable bowel syndrome | 42.35 | 9.93 | 68 | 223303 | 62173 | 79458844 |
Pneumocystis jirovecii pneumonia | 42.30 | 9.93 | 19 | 223352 | 32489 | 79488528 |
Hyperkalaemia | 42.10 | 9.93 | 171 | 223200 | 114227 | 79406790 |
Gastrointestinal haemorrhage | 41.50 | 9.93 | 243 | 223128 | 147476 | 79373541 |
Sleep disorder | 41.37 | 9.93 | 394 | 222977 | 85283 | 79435734 |
Dry mouth | 41.14 | 9.93 | 402 | 222969 | 87617 | 79433400 |
Drug resistance | 40.65 | 9.93 | 35 | 223336 | 42178 | 79478839 |
Skin haemorrhage | 40.59 | 9.93 | 98 | 223273 | 11883 | 79509134 |
Coronary artery disease | 40.47 | 9.93 | 76 | 223295 | 65398 | 79455619 |
Hypomagnesaemia | 40.39 | 9.93 | 43 | 223328 | 46868 | 79474149 |
Agranulocytosis | 40.21 | 9.93 | 40 | 223331 | 44990 | 79476027 |
Therapeutic product effect decreased | 40.18 | 9.93 | 281 | 223090 | 163582 | 79357435 |
Major depression | 40.06 | 9.93 | 82 | 223289 | 8898 | 79512119 |
Myoclonus | 39.52 | 9.93 | 168 | 223203 | 27492 | 79493525 |
Psychotic disorder | 39.46 | 9.93 | 224 | 223147 | 41178 | 79479839 |
Autonomic dysreflexia | 39.42 | 9.93 | 21 | 223350 | 427 | 79520590 |
Paranoia | 39.38 | 9.93 | 132 | 223239 | 19300 | 79501717 |
Rapid eye movements sleep abnormal | 39.25 | 9.93 | 18 | 223353 | 261 | 79520756 |
Akathisia | 39.21 | 9.93 | 103 | 223268 | 13156 | 79507861 |
Cystitis | 38.81 | 9.93 | 267 | 223104 | 52465 | 79468552 |
Acute myeloid leukaemia | 38.72 | 9.93 | 19 | 223352 | 30866 | 79490151 |
Cardiac failure congestive | 38.56 | 9.93 | 237 | 223134 | 142165 | 79378852 |
Bone density abnormal | 38.20 | 9.93 | 45 | 223326 | 3015 | 79518002 |
Analgesic drug level above therapeutic | 37.70 | 9.93 | 21 | 223350 | 468 | 79520549 |
Hypersomnia | 37.58 | 9.93 | 146 | 223225 | 22940 | 79498077 |
Rebound nasal congestion | 37.55 | 9.93 | 10 | 223361 | 21 | 79520996 |
Hostility | 37.53 | 9.93 | 39 | 223332 | 2271 | 79518746 |
Head injury | 37.49 | 9.93 | 205 | 223166 | 37164 | 79483853 |
Muscle twitching | 37.41 | 9.93 | 153 | 223218 | 24611 | 79496406 |
Muscle spasms | 37.19 | 9.93 | 692 | 222679 | 174038 | 79346979 |
Anovulatory cycle | 36.84 | 9.93 | 14 | 223357 | 122 | 79520895 |
Disseminated intravascular coagulation | 36.65 | 9.93 | 28 | 223343 | 35814 | 79485203 |
Neck mass | 36.60 | 9.93 | 53 | 223318 | 4351 | 79516666 |
Tubulointerstitial nephritis | 36.46 | 9.93 | 32 | 223339 | 38203 | 79482814 |
Haemoptysis | 36.41 | 9.93 | 63 | 223308 | 55936 | 79465081 |
Alanine aminotransferase increased | 36.41 | 9.93 | 649 | 222722 | 161921 | 79359096 |
Concussion | 35.77 | 9.93 | 81 | 223290 | 9422 | 79511595 |
Neuralgia | 35.44 | 9.93 | 186 | 223185 | 33198 | 79487819 |
Sacroiliitis | 35.40 | 9.93 | 48 | 223323 | 3706 | 79517311 |
Sensitivity to weather change | 35.33 | 9.93 | 73 | 223298 | 7974 | 79513043 |
Sleep-related eating disorder | 35.18 | 9.93 | 23 | 223348 | 691 | 79520326 |
Bipolar disorder | 35.12 | 9.93 | 71 | 223300 | 7636 | 79513381 |
Ankle fracture | 35.04 | 9.93 | 116 | 223255 | 16853 | 79504164 |
Gait disturbance | 35.01 | 9.93 | 794 | 222577 | 206712 | 79314305 |
Toxic epidermal necrolysis | 34.99 | 9.93 | 44 | 223327 | 44537 | 79476480 |
Product use in unapproved indication | 34.64 | 9.93 | 493 | 222878 | 249866 | 79271151 |
Aspergillus infection | 34.53 | 9.93 | 6 | 223365 | 19155 | 79501862 |
Bronchial haemorrhage | 34.43 | 9.93 | 29 | 223342 | 1291 | 79519726 |
Delusion of grandeur | 34.38 | 9.93 | 30 | 223341 | 1402 | 79519615 |
Cardiogenic shock | 34.35 | 9.93 | 40 | 223331 | 41874 | 79479143 |
Decompression sickness | 34.10 | 9.93 | 12 | 223359 | 82 | 79520935 |
Palmar-plantar erythrodysaesthesia syndrome | 33.74 | 9.93 | 26 | 223345 | 33108 | 79487909 |
Ill-defined disorder | 33.66 | 9.93 | 85 | 223286 | 65790 | 79455227 |
Post cholecystectomy syndrome | 33.44 | 9.93 | 18 | 223353 | 374 | 79520643 |
Oesophageal pain | 33.40 | 9.93 | 50 | 223321 | 4229 | 79516788 |
Premature delivery | 33.33 | 9.93 | 12 | 223359 | 23455 | 79497562 |
Sinus disorder | 33.31 | 9.93 | 138 | 223233 | 22326 | 79498691 |
Joint noise | 33.28 | 9.93 | 48 | 223323 | 3926 | 79517091 |
Melaena | 33.14 | 9.93 | 76 | 223295 | 60814 | 79460203 |
Libido decreased | 33.04 | 9.93 | 56 | 223315 | 5265 | 79515752 |
Spinal operation | 32.65 | 9.93 | 70 | 223301 | 7847 | 79513170 |
Epistaxis | 32.64 | 9.93 | 181 | 223190 | 111334 | 79409683 |
Rheumatoid nodule | 32.45 | 9.93 | 5 | 223366 | 17433 | 79503584 |
Psychotic disorder due to a general medical condition | 32.45 | 9.93 | 16 | 223355 | 275 | 79520742 |
Hypoaesthesia | 32.38 | 9.93 | 693 | 222678 | 178659 | 79342358 |
Aggression | 31.76 | 9.93 | 248 | 223123 | 50710 | 79470307 |
Adjustment disorder | 31.60 | 9.93 | 47 | 223324 | 3953 | 79517064 |
Respiratory tract congestion | 31.51 | 9.93 | 125 | 223246 | 19829 | 79501188 |
Blood lactate dehydrogenase increased | 31.44 | 9.93 | 38 | 223333 | 39132 | 79481885 |
Antidepressant drug level above therapeutic | 31.42 | 9.93 | 21 | 223350 | 655 | 79520362 |
Nervousness | 31.33 | 9.93 | 180 | 223191 | 33235 | 79487782 |
Cerebral infarction | 30.98 | 9.93 | 50 | 223321 | 45626 | 79475391 |
Respiratory tract malformation | 30.95 | 9.93 | 12 | 223359 | 111 | 79520906 |
Sinus congestion | 30.91 | 9.93 | 124 | 223247 | 19772 | 79501245 |
Demyelination | 30.88 | 9.93 | 69 | 223302 | 7954 | 79513063 |
C-reactive protein increased | 30.78 | 9.93 | 223 | 223148 | 128804 | 79392213 |
Apathy | 30.72 | 9.93 | 93 | 223278 | 12884 | 79508133 |
Phagophobia | 30.71 | 9.93 | 10 | 223361 | 52 | 79520965 |
Bacteraemia | 30.66 | 9.93 | 28 | 223343 | 32796 | 79488221 |
Lactic acidosis | 30.64 | 9.93 | 98 | 223273 | 70261 | 79450756 |
Muscle spasticity | 30.35 | 9.93 | 130 | 223241 | 21345 | 79499672 |
Prostate cancer | 30.34 | 9.93 | 29 | 223342 | 33239 | 79487778 |
Intentional product use issue | 30.28 | 9.93 | 276 | 223095 | 151836 | 79369181 |
Speech disorder | 30.18 | 9.93 | 258 | 223113 | 54187 | 79466830 |
Formication | 30.05 | 9.93 | 52 | 223319 | 4971 | 79516046 |
Haematuria | 29.89 | 9.93 | 96 | 223275 | 68740 | 79452277 |
Impaired driving ability | 29.74 | 9.93 | 54 | 223317 | 5361 | 79515656 |
Tumour lysis syndrome | 29.60 | 9.93 | 15 | 223356 | 23924 | 79497093 |
Live birth | 29.46 | 9.93 | 8 | 223363 | 18736 | 79502281 |
Psychomotor hyperactivity | 29.44 | 9.93 | 109 | 223262 | 16740 | 79504277 |
Poor quality sleep | 29.42 | 9.93 | 134 | 223237 | 22588 | 79498429 |
Aplastic anaemia | 29.37 | 9.93 | 7 | 223364 | 17898 | 79503119 |
Product tampering | 29.28 | 9.93 | 17 | 223354 | 411 | 79520606 |
Hypnopompic hallucination | 29.24 | 9.93 | 11 | 223360 | 93 | 79520924 |
Metabolic surgery | 29.00 | 9.93 | 25 | 223346 | 1149 | 79519868 |
Neoplasm progression | 28.54 | 9.93 | 64 | 223307 | 51618 | 79469399 |
Respiratory distress | 28.49 | 9.93 | 77 | 223294 | 58262 | 79462755 |
Alcoholism | 28.35 | 9.93 | 43 | 223328 | 3680 | 79517337 |
Dehydration | 28.22 | 9.93 | 507 | 222864 | 247680 | 79273337 |
Peripheral swelling | 28.13 | 9.93 | 559 | 222812 | 269058 | 79251959 |
Enterococcal infection | 28.01 | 9.93 | 5 | 223366 | 15655 | 79505362 |
Haematotoxicity | 27.66 | 9.93 | 5 | 223366 | 15514 | 79505503 |
Emotional disorder | 27.64 | 9.93 | 96 | 223275 | 14291 | 79506726 |
Galactorrhoea | 27.60 | 9.93 | 42 | 223329 | 3604 | 79517413 |
Cholestasis | 27.59 | 9.93 | 66 | 223305 | 52043 | 79468974 |
Metabolic acidosis | 27.53 | 9.93 | 128 | 223243 | 82401 | 79438616 |
Lung disorder | 26.84 | 9.93 | 125 | 223246 | 80432 | 79440585 |
Gastrooesophageal reflux disease | 26.56 | 9.93 | 425 | 222946 | 103821 | 79417196 |
Adulterated product | 26.49 | 9.93 | 14 | 223357 | 280 | 79520737 |
Blood immunoglobulin A increased | 26.47 | 9.93 | 22 | 223349 | 961 | 79520056 |
Poor sucking reflex | 26.45 | 9.93 | 11 | 223360 | 124 | 79520893 |
Graft versus host disease | 26.44 | 9.93 | 5 | 223366 | 15021 | 79505996 |
Aspartate aminotransferase increased | 26.42 | 9.93 | 540 | 222831 | 138101 | 79382916 |
Toxic skin eruption | 26.06 | 9.93 | 15 | 223356 | 22278 | 79498739 |
Thrombotic microangiopathy | 25.91 | 9.93 | 12 | 223359 | 20157 | 79500860 |
Lactation disorder | 25.88 | 9.93 | 13 | 223358 | 233 | 79520784 |
Carcinoid tumour pulmonary | 25.60 | 9.93 | 15 | 223356 | 369 | 79520648 |
Lymphocyte count abnormal | 25.55 | 9.93 | 26 | 223345 | 1477 | 79519540 |
Cognitive disorder | 25.53 | 9.93 | 304 | 223067 | 69622 | 79451395 |
Blood calcium decreased | 25.40 | 9.93 | 31 | 223340 | 31788 | 79489229 |
Cataplexy | 25.36 | 9.93 | 21 | 223350 | 913 | 79520104 |
Therapy non-responder | 25.31 | 9.93 | 153 | 223218 | 92152 | 79428865 |
Pain in extremity | 25.28 | 9.93 | 1256 | 222115 | 363282 | 79157735 |
Suspected suicide | 25.23 | 9.93 | 76 | 223295 | 10500 | 79510517 |
Neck pain | 25.00 | 9.93 | 322 | 223049 | 75095 | 79445922 |
Creatinine renal clearance decreased | 24.89 | 9.93 | 11 | 223360 | 18991 | 79502026 |
Thunderclap headache | 24.86 | 9.93 | 15 | 223356 | 390 | 79520627 |
Pathogen resistance | 24.76 | 9.93 | 5 | 223366 | 14337 | 79506680 |
Loss of control of legs | 24.70 | 9.93 | 29 | 223342 | 1936 | 79519081 |
Product use issue | 24.69 | 9.93 | 426 | 222945 | 209396 | 79311621 |
Gastrointestinal disorder | 24.64 | 9.93 | 221 | 223150 | 121984 | 79399033 |
Drug eruption | 24.60 | 9.93 | 54 | 223317 | 43881 | 79477136 |
Bladder cancer | 24.50 | 9.93 | 12 | 223359 | 19514 | 79501503 |
Skin necrosis | 24.44 | 9.93 | 10 | 223361 | 18077 | 79502940 |
Eosinophilia | 24.36 | 9.93 | 57 | 223314 | 45288 | 79475729 |
Pulseless electrical activity | 24.31 | 9.93 | 5 | 223366 | 14155 | 79506862 |
Drug screen positive | 24.30 | 9.93 | 53 | 223318 | 6010 | 79515007 |
Growth hormone deficiency | 24.00 | 9.93 | 15 | 223356 | 416 | 79520601 |
Dystonia | 23.94 | 9.93 | 121 | 223250 | 21278 | 79499739 |
Snoring | 23.86 | 9.93 | 50 | 223321 | 5516 | 79515501 |
Tenosynovitis | 23.77 | 9.93 | 7 | 223364 | 15547 | 79505470 |
Myelodysplastic syndrome | 23.68 | 9.93 | 30 | 223341 | 30271 | 79490746 |
Bradycardia | 23.62 | 9.93 | 254 | 223117 | 135303 | 79385714 |
Genital pain | 23.57 | 9.93 | 19 | 223352 | 795 | 79520222 |
Lip dry | 23.45 | 9.93 | 7 | 223364 | 15411 | 79505606 |
Dissociative disorder | 23.42 | 9.93 | 19 | 223352 | 802 | 79520215 |
Ejection fraction decreased | 23.31 | 9.93 | 38 | 223333 | 34539 | 79486478 |
Middle insomnia | 23.27 | 9.93 | 98 | 223273 | 15971 | 79505046 |
Post-traumatic neck syndrome | 23.22 | 9.93 | 29 | 223342 | 2065 | 79518952 |
Bruxism | 23.20 | 9.93 | 41 | 223330 | 3985 | 79517032 |
Product used for unknown indication | 23.19 | 9.93 | 25 | 223346 | 1519 | 79519498 |
Muscular weakness | 23.17 | 9.93 | 602 | 222769 | 160127 | 79360890 |
Pseudomonas infection | 23.13 | 9.93 | 15 | 223356 | 20888 | 79500129 |
Hypokalaemia | 23.09 | 9.93 | 275 | 223096 | 143765 | 79377252 |
Epstein-Barr virus infection | 22.94 | 9.93 | 6 | 223365 | 14410 | 79506607 |
Speech sound disorder | 22.94 | 9.93 | 8 | 223363 | 53 | 79520964 |
Musculoskeletal discomfort | 22.79 | 9.93 | 113 | 223258 | 19722 | 79501295 |
Second primary malignancy | 22.79 | 9.93 | 6 | 223365 | 14344 | 79506673 |
Hypotension | 22.70 | 9.93 | 1005 | 222366 | 439312 | 79081705 |
Electric shock sensation | 22.67 | 9.93 | 19 | 223352 | 840 | 79520177 |
Hypoalbuminaemia | 22.60 | 9.93 | 16 | 223355 | 21281 | 79499736 |
Proteinuria | 22.59 | 9.93 | 35 | 223336 | 32467 | 79488550 |
Acute myocardial infarction | 22.56 | 9.93 | 125 | 223246 | 76911 | 79444106 |
Delusion | 22.51 | 9.93 | 115 | 223256 | 20308 | 79500709 |
Acute pulmonary oedema | 22.50 | 9.93 | 6 | 223365 | 14224 | 79506793 |
Feeling guilty | 22.50 | 9.93 | 19 | 223352 | 849 | 79520168 |
Eating disorder | 22.44 | 9.93 | 116 | 223255 | 20581 | 79500436 |
Acute respiratory distress syndrome | 22.40 | 9.93 | 57 | 223314 | 44010 | 79477007 |
Maternal exposure during breast feeding | 22.40 | 9.93 | 33 | 223338 | 2752 | 79518265 |
Pneumonitis | 22.37 | 9.93 | 91 | 223280 | 60769 | 79460248 |
Poisoning | 22.31 | 9.93 | 134 | 223237 | 25138 | 79495879 |
Hepatotoxicity | 22.03 | 9.93 | 72 | 223299 | 51280 | 79469737 |
Anorgasmia | 21.88 | 9.93 | 22 | 223349 | 1232 | 79519785 |
Somnambulism | 21.79 | 9.93 | 49 | 223322 | 5672 | 79515345 |
Hyperglycaemia | 21.78 | 9.93 | 112 | 223259 | 70223 | 79450794 |
Deep vein thrombosis | 21.70 | 9.93 | 225 | 223146 | 120694 | 79400323 |
Pre-existing condition improved | 21.59 | 9.93 | 48 | 223323 | 5515 | 79515502 |
Pustular psoriasis | 21.57 | 9.93 | 44 | 223327 | 4762 | 79516255 |
Feeling jittery | 21.55 | 9.93 | 82 | 223289 | 12759 | 79508258 |
Metastases to bone | 21.47 | 9.93 | 22 | 223349 | 24405 | 79496612 |
Hypoventilation | 21.24 | 9.93 | 56 | 223315 | 7168 | 79513849 |
Depressive symptom | 21.18 | 9.93 | 52 | 223319 | 6371 | 79514646 |
Device related infection | 21.02 | 9.93 | 40 | 223331 | 34254 | 79486763 |
Pulmonary eosinophilia | 20.83 | 9.93 | 17 | 223354 | 724 | 79520293 |
Gambling disorder | 20.79 | 9.93 | 27 | 223344 | 1999 | 79519018 |
Bronchial disorder | 20.75 | 9.93 | 30 | 223341 | 2459 | 79518558 |
Myocardial infarction | 20.65 | 9.93 | 377 | 222994 | 183752 | 79337265 |
Inflammation | 20.49 | 9.93 | 166 | 223205 | 93587 | 79427430 |
Abortion spontaneous | 20.30 | 9.93 | 147 | 223224 | 29360 | 79491657 |
Hypoxia | 20.25 | 9.93 | 188 | 223183 | 103055 | 79417962 |
Hypertonia | 20.20 | 9.93 | 55 | 223316 | 7177 | 79513840 |
Urinary incontinence | 20.18 | 9.93 | 189 | 223182 | 40720 | 79480297 |
Oedema | 20.06 | 9.93 | 226 | 223145 | 119354 | 79401663 |
Palpitations | 19.96 | 9.93 | 480 | 222891 | 126130 | 79394887 |
International normalised ratio increased | 19.93 | 9.93 | 147 | 223224 | 84574 | 79436443 |
Aspartate aminotransferase | 19.90 | 9.93 | 15 | 223356 | 568 | 79520449 |
Increased appetite | 19.70 | 9.93 | 76 | 223295 | 11902 | 79509115 |
Sexual dysfunction | 19.68 | 9.93 | 57 | 223314 | 7706 | 79513311 |
Dyspnoea exertional | 19.57 | 9.93 | 153 | 223218 | 86920 | 79434097 |
Phobia of driving | 19.52 | 9.93 | 4 | 223367 | 0 | 79521017 |
Depression suicidal | 19.46 | 9.93 | 37 | 223334 | 3805 | 79517212 |
Therapeutic response changed | 19.42 | 9.93 | 21 | 223350 | 1280 | 79519737 |
Tension | 19.39 | 9.93 | 40 | 223331 | 4364 | 79516653 |
Rhonchi | 19.38 | 9.93 | 38 | 223333 | 3998 | 79517019 |
Angioedema | 19.32 | 9.93 | 129 | 223242 | 75906 | 79445111 |
Hepatitis E antibody positive | 19.28 | 9.93 | 11 | 223360 | 257 | 79520760 |
Mydriasis | 19.21 | 9.93 | 99 | 223272 | 17544 | 79503473 |
Metastases to liver | 19.20 | 9.93 | 31 | 223340 | 28283 | 79492734 |
Cytomegalovirus viraemia | 19.18 | 9.93 | 6 | 223365 | 12815 | 79508202 |
Drug abuse | 19.18 | 9.93 | 594 | 222777 | 162097 | 79358920 |
Hip arthroplasty | 19.16 | 9.93 | 45 | 223326 | 35711 | 79485306 |
Motor dysfunction | 19.16 | 9.93 | 87 | 223284 | 14646 | 79506371 |
Ankylosing spondylitis | 18.91 | 9.93 | 76 | 223295 | 12129 | 79508888 |
Progressive multiple sclerosis | 18.80 | 9.93 | 20 | 223351 | 1197 | 79519820 |
Initial insomnia | 18.62 | 9.93 | 52 | 223319 | 6886 | 79514131 |
Drug screen false positive | 18.52 | 9.93 | 19 | 223352 | 1090 | 79519927 |
Shoulder operation | 18.48 | 9.93 | 30 | 223341 | 2722 | 79518295 |
Hyperbilirubinaemia | 18.42 | 9.93 | 25 | 223346 | 24493 | 79496524 |
Homicidal ideation | 18.39 | 9.93 | 34 | 223337 | 3423 | 79517594 |
Exposure via breast milk | 18.35 | 9.93 | 18 | 223353 | 978 | 79520039 |
Aphasia | 18.32 | 9.93 | 206 | 223165 | 46526 | 79474491 |
Nephrolithiasis | 18.29 | 9.93 | 229 | 223142 | 53062 | 79467955 |
Product prescribing error | 18.24 | 9.93 | 199 | 223172 | 44614 | 79476403 |
Hepatitis E virus test positive | 18.23 | 9.93 | 11 | 223360 | 286 | 79520731 |
Bone erosion | 18.18 | 9.93 | 14 | 223357 | 17833 | 79503184 |
Respiratory depression | 18.07 | 9.93 | 136 | 223235 | 27494 | 79493523 |
Pulmonary oedema | 18.05 | 9.93 | 159 | 223212 | 88095 | 79432922 |
Arteriosclerosis coronary artery | 18.05 | 9.93 | 98 | 223273 | 17718 | 79503299 |
Urinary tract infection | 18.03 | 9.93 | 941 | 222430 | 273571 | 79247446 |
Decreased interest | 17.98 | 9.93 | 35 | 223336 | 3662 | 79517355 |
Road traffic accident | 17.82 | 9.93 | 194 | 223177 | 43470 | 79477547 |
Scar | 17.76 | 9.93 | 87 | 223284 | 15109 | 79505908 |
Dysphagia | 17.75 | 9.93 | 458 | 222913 | 121678 | 79399339 |
Basal cell carcinoma | 17.75 | 9.93 | 50 | 223321 | 37325 | 79483692 |
Haemophagocytic lymphohistiocytosis | 17.72 | 9.93 | 21 | 223350 | 21816 | 79499201 |
Spinal disorder | 17.61 | 9.93 | 66 | 223305 | 10194 | 79510823 |
Flat affect | 17.60 | 9.93 | 25 | 223346 | 2016 | 79519001 |
CYP3A4 polymorphism | 17.58 | 9.93 | 7 | 223364 | 70 | 79520947 |
Haemodialysis | 17.57 | 9.93 | 15 | 223356 | 18153 | 79502864 |
Feeling drunk | 17.51 | 9.93 | 40 | 223331 | 4679 | 79516338 |
Vasculitis | 17.48 | 9.93 | 27 | 223344 | 25075 | 79495942 |
Compulsive shopping | 17.42 | 9.93 | 16 | 223355 | 800 | 79520217 |
Haemorrhage | 17.41 | 9.93 | 167 | 223204 | 90951 | 79430066 |
Pneumothorax | 17.39 | 9.93 | 33 | 223338 | 28290 | 79492727 |
Renal tubular necrosis | 17.37 | 9.93 | 27 | 223344 | 25012 | 79496005 |
Liver disorder | 17.34 | 9.93 | 125 | 223246 | 72292 | 79448725 |
Intestinal perforation | 17.33 | 9.93 | 14 | 223357 | 17412 | 79503605 |
Hyponatraemia | 17.32 | 9.93 | 635 | 222736 | 177213 | 79343804 |
Soft tissue injury | 17.14 | 9.93 | 23 | 223348 | 1758 | 79519259 |
Glomerular filtration rate increased | 17.13 | 9.93 | 19 | 223352 | 1192 | 79519825 |
Sensory loss | 17.11 | 9.93 | 77 | 223294 | 12914 | 79508103 |
Vitamin B12 increased | 17.10 | 9.93 | 19 | 223352 | 1194 | 79519823 |
Dactylitis | 17.10 | 9.93 | 29 | 223342 | 2728 | 79518289 |
Anaphylactic reaction | 17.08 | 9.93 | 151 | 223220 | 83592 | 79437425 |
Neuropathy peripheral | 16.94 | 9.93 | 517 | 222854 | 140788 | 79380229 |
Peritonitis | 16.93 | 9.93 | 33 | 223338 | 28003 | 79493014 |
Sleep talking | 16.91 | 9.93 | 18 | 223353 | 1078 | 79519939 |
Total cholesterol/HDL ratio abnormal | 16.91 | 9.93 | 7 | 223364 | 78 | 79520939 |
Open reduction of fracture | 16.89 | 9.93 | 10 | 223361 | 251 | 79520766 |
Hyponatraemic encephalopathy | 16.87 | 9.93 | 11 | 223360 | 329 | 79520688 |
Ischaemic stroke | 16.73 | 9.93 | 43 | 223328 | 33088 | 79487929 |
Prescribed overdose | 16.72 | 9.93 | 171 | 223200 | 37712 | 79483305 |
Anaphylactic shock | 16.48 | 9.93 | 49 | 223322 | 35947 | 79485070 |
Acute stress disorder | 16.45 | 9.93 | 12 | 223359 | 432 | 79520585 |
Klebsiella infection | 16.44 | 9.93 | 12 | 223359 | 15708 | 79505309 |
Hypercalcaemia | 16.40 | 9.93 | 54 | 223317 | 38376 | 79482641 |
Claustrophobia | 16.39 | 9.93 | 19 | 223352 | 1251 | 79519766 |
Metastases to lung | 16.37 | 9.93 | 16 | 223355 | 18147 | 79502870 |
Scoliosis | 16.29 | 9.93 | 52 | 223319 | 7412 | 79513605 |
Eye pain | 16.29 | 9.93 | 169 | 223202 | 37409 | 79483608 |
Feelings of worthlessness | 16.23 | 9.93 | 13 | 223358 | 539 | 79520478 |
Shock | 16.07 | 9.93 | 65 | 223306 | 43483 | 79477534 |
Illness | 16.02 | 9.93 | 200 | 223171 | 46311 | 79474706 |
Haemolysis | 15.88 | 9.93 | 8 | 223363 | 12804 | 79508213 |
Intervertebral disc protrusion | 15.86 | 9.93 | 117 | 223254 | 23504 | 79497513 |
Haematochezia | 15.76 | 9.93 | 163 | 223208 | 87482 | 79433535 |
Atrioventricular block complete | 15.72 | 9.93 | 14 | 223357 | 16596 | 79504421 |
Haemolytic anaemia | 15.71 | 9.93 | 16 | 223355 | 17804 | 79503213 |
Facet joint syndrome | 15.68 | 9.93 | 6 | 223365 | 11296 | 79509721 |
Granulomatous liver disease | 15.65 | 9.93 | 19 | 223352 | 1314 | 79519703 |
Hepatic steatosis | 15.55 | 9.93 | 168 | 223203 | 37570 | 79483447 |
Lacunar stroke | 15.55 | 9.93 | 11 | 223360 | 377 | 79520640 |
Status epilepticus | 15.53 | 9.93 | 29 | 223342 | 25012 | 79496005 |
Foetal exposure timing unspecified | 15.52 | 9.93 | 6 | 223365 | 55 | 79520962 |
Dysarthria | 15.50 | 9.93 | 271 | 223100 | 67351 | 79453666 |
Rales | 15.43 | 9.93 | 20 | 223351 | 19981 | 79501036 |
Convulsive threshold lowered | 15.41 | 9.93 | 16 | 223355 | 931 | 79520086 |
Poverty of speech | 15.39 | 9.93 | 13 | 223358 | 581 | 79520436 |
Feeling hot | 15.39 | 9.93 | 244 | 223127 | 59490 | 79461527 |
Rectal haemorrhage | 15.37 | 9.93 | 138 | 223233 | 76162 | 79444855 |
Mobility decreased | 15.36 | 9.93 | 245 | 223126 | 121930 | 79399087 |
Amenorrhoea | 15.36 | 9.93 | 52 | 223319 | 7640 | 79513377 |
Pericardial effusion | 15.25 | 9.93 | 72 | 223299 | 46165 | 79474852 |
Renal injury | 15.15 | 9.93 | 15 | 223356 | 16912 | 79504105 |
Oliguria | 15.13 | 9.93 | 14 | 223357 | 16295 | 79504722 |
Genital ulceration | 15.12 | 9.93 | 17 | 223354 | 1083 | 79519934 |
Lymphoma | 15.03 | 9.93 | 16 | 223355 | 17444 | 79503573 |
Ophthalmic vein thrombosis | 15.02 | 9.93 | 9 | 223362 | 231 | 79520786 |
Progressive multifocal leukoencephalopathy | 14.97 | 9.93 | 104 | 223267 | 20496 | 79500521 |
Hypervolaemia | 14.96 | 9.93 | 65 | 223306 | 42625 | 79478392 |
Tearfulness | 14.95 | 9.93 | 44 | 223327 | 6001 | 79515016 |
Burning sensation | 14.91 | 9.93 | 239 | 223132 | 58393 | 79462624 |
Liver injury | 14.91 | 9.93 | 95 | 223276 | 56519 | 79464498 |
Hysterectomy | 14.90 | 9.93 | 45 | 223326 | 6227 | 79514790 |
Rhinalgia | 14.81 | 9.93 | 25 | 223346 | 2342 | 79518675 |
Drug tolerance decreased | 14.79 | 9.93 | 9 | 223362 | 12969 | 79508048 |
Myofascial pain syndrome | 14.77 | 9.93 | 23 | 223348 | 2014 | 79519003 |
Uterine disorder | 14.74 | 9.93 | 24 | 223347 | 2183 | 79518834 |
Clostridium difficile colitis | 14.74 | 9.93 | 44 | 223327 | 32239 | 79488778 |
Atelectasis | 14.70 | 9.93 | 44 | 223327 | 32213 | 79488804 |
Hepatic cytolysis | 14.68 | 9.93 | 34 | 223337 | 27117 | 79493900 |
Complex regional pain syndrome | 14.68 | 9.93 | 23 | 223348 | 2025 | 79518992 |
Thrombocytosis | 14.66 | 9.93 | 3 | 223368 | 8523 | 79512494 |
Immobilisation prolonged | 14.65 | 9.93 | 7 | 223364 | 112 | 79520905 |
Clitoral engorgement | 14.64 | 9.93 | 3 | 223368 | 0 | 79521017 |
Dysstasia | 14.60 | 9.93 | 130 | 223241 | 27616 | 79493401 |
Blood bilirubin increased | 14.60 | 9.93 | 117 | 223254 | 66115 | 79454902 |
Throat irritation | 14.50 | 9.93 | 177 | 223194 | 40769 | 79480248 |
Accidental death | 14.43 | 9.93 | 35 | 223336 | 4256 | 79516761 |
Pulmonary haemorrhage | 14.42 | 9.93 | 12 | 223359 | 14705 | 79506312 |
Coagulopathy | 14.41 | 9.93 | 52 | 223319 | 35954 | 79485063 |
Angina unstable | 14.39 | 9.93 | 15 | 223356 | 16512 | 79504505 |
Peripheral venous disease | 14.36 | 9.93 | 14 | 223357 | 15895 | 79505122 |
Illness anxiety disorder | 14.33 | 9.93 | 9 | 223362 | 252 | 79520765 |
Drug ineffective for unapproved indication | 14.23 | 9.93 | 212 | 223159 | 51026 | 79469991 |
Bone density decreased | 14.20 | 9.93 | 10 | 223361 | 13337 | 79507680 |
Cardiac murmur | 14.19 | 9.93 | 14 | 223357 | 15810 | 79505207 |
Nephropathy toxic | 14.18 | 9.93 | 22 | 223349 | 20397 | 79500620 |
Sinus tachycardia | 14.15 | 9.93 | 162 | 223209 | 36746 | 79484271 |
Visual impairment | 14.13 | 9.93 | 348 | 223023 | 91783 | 79429234 |
Spondyloarthropathy | 14.11 | 9.93 | 16 | 223355 | 1029 | 79519988 |
Metastases to central nervous system | 14.10 | 9.93 | 15 | 223356 | 16360 | 79504657 |
Hypnagogic hallucination | 14.06 | 9.93 | 8 | 223363 | 186 | 79520831 |
Circulatory collapse | 14.04 | 9.93 | 56 | 223315 | 37612 | 79483405 |
Drug metabolising enzyme decreased | 14.01 | 9.93 | 4 | 223367 | 12 | 79521005 |
Anal incontinence | 13.97 | 9.93 | 93 | 223278 | 18075 | 79502942 |
Hepatocellular carcinoma | 13.90 | 9.93 | 4 | 223367 | 9017 | 79512000 |
Pneumonia fungal | 13.90 | 9.93 | 7 | 223364 | 11203 | 79509814 |
Radiation fibrosis | 13.87 | 9.93 | 5 | 223366 | 37 | 79520980 |
Gastric haemorrhage | 13.87 | 9.93 | 13 | 223358 | 15037 | 79505980 |
Therapeutic product effect incomplete | 13.85 | 9.93 | 506 | 222865 | 141139 | 79379878 |
Social avoidant behaviour | 13.83 | 9.93 | 37 | 223334 | 4777 | 79516240 |
Bronchiectasis | 13.82 | 9.93 | 26 | 223345 | 22360 | 79498657 |
Rheumatoid factor increased | 13.82 | 9.93 | 21 | 223350 | 1800 | 79519217 |
Nephrotic syndrome | 13.82 | 9.93 | 7 | 223364 | 11167 | 79509850 |
Obsessive-compulsive personality disorder | 13.81 | 9.93 | 7 | 223364 | 128 | 79520889 |
Acute hepatic failure | 13.78 | 9.93 | 41 | 223330 | 30072 | 79490945 |
Rapid eye movement sleep behaviour disorder | 13.75 | 9.93 | 11 | 223360 | 455 | 79520562 |
Colitis | 13.73 | 9.93 | 135 | 223236 | 73172 | 79447845 |
Rib fracture | 13.72 | 9.93 | 129 | 223242 | 27818 | 79493199 |
Hypokinesia | 13.72 | 9.93 | 96 | 223275 | 18964 | 79502053 |
Persistent genital arousal disorder | 13.72 | 9.93 | 9 | 223362 | 272 | 79520745 |
Hypoglycaemia | 13.70 | 9.93 | 201 | 223170 | 101393 | 79419624 |
Hyperuricaemia | 13.70 | 9.93 | 8 | 223363 | 11791 | 79509226 |
Respiratory arrest | 13.68 | 9.93 | 232 | 223139 | 57318 | 79463699 |
Pyometra | 13.67 | 9.93 | 6 | 223365 | 78 | 79520939 |
Metastases to lymph nodes | 13.65 | 9.93 | 6 | 223365 | 10391 | 79510626 |
Reversible airways obstruction | 13.64 | 9.93 | 23 | 223348 | 2153 | 79518864 |
Chronic kidney disease | 13.61 | 9.93 | 119 | 223252 | 66035 | 79454982 |
Sternal fracture | 13.60 | 9.93 | 25 | 223346 | 2505 | 79518512 |
Febrile bone marrow aplasia | 13.53 | 9.93 | 10 | 223361 | 13010 | 79508007 |
Intervertebral disc operation | 13.52 | 9.93 | 15 | 223356 | 941 | 79520076 |
Urinary hesitation | 13.50 | 9.93 | 34 | 223337 | 4232 | 79516785 |
Oesophagitis | 13.47 | 9.93 | 30 | 223341 | 24259 | 79496758 |
Multiple-drug resistance | 13.40 | 9.93 | 4 | 223367 | 8804 | 79512213 |
Extrapyramidal disorder | 13.38 | 9.93 | 109 | 223262 | 22570 | 79498447 |
Cushingoid | 13.37 | 9.93 | 5 | 223366 | 9547 | 79511470 |
Posterior reversible encephalopathy syndrome | 13.35 | 9.93 | 34 | 223337 | 26247 | 79494770 |
Back disorder | 13.33 | 9.93 | 66 | 223305 | 11512 | 79509505 |
Pulmonary toxicity | 13.32 | 9.93 | 10 | 223361 | 12904 | 79508113 |
Post concussion syndrome | 13.30 | 9.93 | 12 | 223359 | 586 | 79520431 |
Gambling | 13.18 | 9.93 | 9 | 223362 | 291 | 79520726 |
Reaction to azo-dyes | 13.13 | 9.93 | 4 | 223367 | 16 | 79521001 |
Illusion | 13.10 | 9.93 | 20 | 223351 | 1721 | 79519296 |
Tachyphrenia | 13.06 | 9.93 | 22 | 223349 | 2058 | 79518959 |
Colorectal cancer | 13.02 | 9.93 | 4 | 223367 | 8643 | 79512374 |
Tuberculosis | 13.00 | 9.93 | 14 | 223357 | 15184 | 79505833 |
Granulocyte count increased | 12.99 | 9.93 | 17 | 223354 | 1268 | 79519749 |
Myocardial ischaemia | 12.98 | 9.93 | 33 | 223338 | 25486 | 79495531 |
Embolism | 12.97 | 9.93 | 12 | 223359 | 13970 | 79507047 |
Panic disorder | 12.97 | 9.93 | 27 | 223344 | 2965 | 79518052 |
Transfusion | 12.97 | 9.93 | 25 | 223346 | 21305 | 79499712 |
Economic problem | 12.93 | 9.93 | 23 | 223348 | 2247 | 79518770 |
Escherichia infection | 12.91 | 9.93 | 19 | 223352 | 17998 | 79503019 |
Pulse abnormal | 12.91 | 9.93 | 29 | 223342 | 3355 | 79517662 |
Hyperventilation | 12.89 | 9.93 | 50 | 223321 | 7849 | 79513168 |
Diplopia | 12.88 | 9.93 | 147 | 223224 | 33319 | 79487698 |
Adiposis dolorosa | 12.84 | 9.93 | 9 | 223362 | 304 | 79520713 |
Impulse-control disorder | 12.82 | 9.93 | 20 | 223351 | 1754 | 79519263 |
Ventricular hypokinesia | 12.75 | 9.93 | 5 | 223366 | 9274 | 79511743 |
Lupus-like syndrome | 12.73 | 9.93 | 12 | 223359 | 13845 | 79507172 |
Seizure | 12.73 | 9.93 | 649 | 222722 | 188185 | 79332832 |
Drug level decreased | 12.62 | 9.93 | 13 | 223358 | 14389 | 79506628 |
Cardiac failure acute | 12.57 | 9.93 | 21 | 223350 | 18908 | 79502109 |
Floating patella | 12.57 | 9.93 | 3 | 223368 | 3 | 79521014 |
Psychopathic personality | 12.57 | 9.93 | 3 | 223368 | 3 | 79521014 |
Acute graft versus host disease in skin | 12.55 | 9.93 | 3 | 223368 | 7655 | 79513362 |
Movement disorder | 12.49 | 9.93 | 124 | 223247 | 27135 | 79493882 |
Mean cell haemoglobin concentration increased | 12.49 | 9.93 | 14 | 223357 | 889 | 79520128 |
Application site perspiration | 12.41 | 9.93 | 4 | 223367 | 20 | 79520997 |
Serum serotonin increased | 12.41 | 9.93 | 9 | 223362 | 321 | 79520696 |
Lymphoedema | 12.38 | 9.93 | 68 | 223303 | 12345 | 79508672 |
Forced expiratory volume decreased | 12.38 | 9.93 | 49 | 223322 | 7765 | 79513252 |
Facial spasm | 12.36 | 9.93 | 13 | 223358 | 768 | 79520249 |
Right ventricular failure | 12.25 | 9.93 | 30 | 223341 | 23467 | 79497550 |
Loose tooth | 12.21 | 9.93 | 27 | 223344 | 3090 | 79517927 |
Back pain | 12.21 | 9.93 | 1000 | 222371 | 303180 | 79217837 |
Vitamin D deficiency | 12.15 | 9.93 | 75 | 223296 | 14204 | 79506813 |
Lung infiltration | 12.14 | 9.93 | 29 | 223342 | 22883 | 79498134 |
Burning mouth syndrome | 12.11 | 9.93 | 11 | 223360 | 542 | 79520475 |
Tongue movement disturbance | 12.09 | 9.93 | 10 | 223361 | 434 | 79520583 |
Adverse event | 12.09 | 9.93 | 109 | 223262 | 60105 | 79460912 |
Diarrhoea | 12.03 | 9.93 | 2228 | 221143 | 878261 | 78642756 |
Sinus pain | 12.03 | 9.93 | 30 | 223341 | 3712 | 79517305 |
Pregnancy | 11.97 | 9.93 | 37 | 223334 | 26814 | 79494203 |
Infective pulmonary exacerbation of cystic fibrosis | 11.96 | 9.93 | 11 | 223360 | 12840 | 79508177 |
Delirium | 11.91 | 9.93 | 316 | 223055 | 84311 | 79436706 |
Hyperthyroidism | 11.86 | 9.93 | 28 | 223343 | 22181 | 79498836 |
Trismus | 11.85 | 9.93 | 38 | 223333 | 5429 | 79515588 |
Haemoglobin urine present | 11.85 | 9.93 | 14 | 223357 | 941 | 79520076 |
Sciatic nerve injury | 11.81 | 9.93 | 11 | 223360 | 560 | 79520457 |
Breast cancer stage II | 11.79 | 9.93 | 4 | 223367 | 8116 | 79512901 |
Diffuse large B-cell lymphoma | 11.79 | 9.93 | 10 | 223361 | 12139 | 79508878 |
Nasal polyps | 11.76 | 9.93 | 3 | 223368 | 7324 | 79513693 |
Tachypnoea | 11.74 | 9.93 | 48 | 223323 | 32015 | 79489002 |
Red blood cell sedimentation rate increased | 11.64 | 9.93 | 78 | 223293 | 45864 | 79475153 |
Supraventricular tachyarrhythmia | 11.63 | 9.93 | 6 | 223365 | 114 | 79520903 |
Foetal death | 11.62 | 9.93 | 4 | 223367 | 8040 | 79512977 |
Panic reaction | 11.58 | 9.93 | 34 | 223337 | 4631 | 79516386 |
Purple glove syndrome | 11.57 | 9.93 | 8 | 223363 | 264 | 79520753 |
Trigger finger | 11.57 | 9.93 | 32 | 223339 | 4213 | 79516804 |
Blood cholesterol increased | 11.51 | 9.93 | 165 | 223206 | 83555 | 79437462 |
Dental restoration failure | 11.51 | 9.93 | 14 | 223357 | 970 | 79520047 |
Skin plaque | 11.50 | 9.93 | 8 | 223363 | 10737 | 79510280 |
Ligament injury | 11.45 | 9.93 | 15 | 223356 | 1120 | 79519897 |
Somatic delusion | 11.45 | 9.93 | 12 | 223359 | 706 | 79520311 |
Holmes-Adie pupil | 11.41 | 9.93 | 4 | 223367 | 27 | 79520990 |
Heart rate decreased | 11.36 | 9.93 | 134 | 223237 | 70182 | 79450835 |
Leukoencephalopathy | 11.35 | 9.93 | 4 | 223367 | 7925 | 79513092 |
Menopausal symptoms | 11.32 | 9.93 | 20 | 223351 | 1943 | 79519074 |
Dermatitis acneiform | 11.29 | 9.93 | 7 | 223364 | 9986 | 79511031 |
Dysphemia | 11.27 | 9.93 | 28 | 223343 | 3456 | 79517561 |
Axillary pain | 11.26 | 9.93 | 21 | 223350 | 2128 | 79518889 |
Exposure via ingestion | 11.25 | 9.93 | 36 | 223335 | 5138 | 79515879 |
Influenza | 11.25 | 9.93 | 457 | 222914 | 129149 | 79391868 |
Impulsive behaviour | 11.23 | 9.93 | 25 | 223346 | 2875 | 79518142 |
Withdrawal hypertension | 11.20 | 9.93 | 9 | 223362 | 375 | 79520642 |
Incontinence | 11.19 | 9.93 | 73 | 223298 | 14091 | 79506926 |
Blood bilirubin | 11.16 | 9.93 | 4 | 223367 | 29 | 79520988 |
Product monitoring error | 11.14 | 9.93 | 52 | 223319 | 8854 | 79512163 |
Forced expiratory flow decreased | 11.14 | 9.93 | 8 | 223363 | 281 | 79520736 |
Skin lesion | 11.13 | 9.93 | 70 | 223301 | 41774 | 79479243 |
Abulia | 11.11 | 9.93 | 14 | 223357 | 1006 | 79520011 |
Pruritus | 11.08 | 9.93 | 953 | 222418 | 393695 | 79127322 |
Hospitalisation | 11.08 | 9.93 | 344 | 223027 | 93892 | 79427125 |
Hepatic cancer | 11.06 | 9.93 | 8 | 223363 | 10521 | 79510496 |
Hypogammaglobulinaemia | 11.00 | 9.93 | 12 | 223359 | 12939 | 79508078 |
Oesophageal food impaction | 10.97 | 9.93 | 9 | 223362 | 386 | 79520631 |
Shock haemorrhagic | 10.95 | 9.93 | 25 | 223346 | 20035 | 79500982 |
Apnoea | 10.94 | 9.93 | 63 | 223308 | 11641 | 79509376 |
Binge eating | 10.91 | 9.93 | 10 | 223361 | 499 | 79520518 |
Cachexia | 10.90 | 9.93 | 9 | 223362 | 11074 | 79509943 |
Alveolar bone resorption | 10.87 | 9.93 | 5 | 223366 | 73 | 79520944 |
Blood alkaline phosphatase increased | 10.84 | 9.93 | 244 | 223127 | 63420 | 79457597 |
Paralogism | 10.82 | 9.93 | 4 | 223367 | 32 | 79520985 |
Large intestine perforation | 10.79 | 9.93 | 15 | 223356 | 14552 | 79506465 |
Bacterial infection | 10.74 | 9.93 | 48 | 223323 | 31232 | 79489785 |
Hypophosphataemia | 10.72 | 9.93 | 25 | 223346 | 19888 | 79501129 |
Polyarthritis | 10.71 | 9.93 | 11 | 223360 | 12191 | 79508826 |
Blood prolactin increased | 10.70 | 9.93 | 30 | 223341 | 3981 | 79517036 |
Rhabdomyolysis | 10.69 | 9.93 | 214 | 223157 | 102917 | 79418100 |
Pulmonary arterial hypertension | 10.68 | 9.93 | 42 | 223329 | 28324 | 79492693 |
Ocular vascular disorder | 10.66 | 9.93 | 10 | 223361 | 514 | 79520503 |
Cytopenia | 10.65 | 9.93 | 26 | 223345 | 20357 | 79500660 |
Meralgia paraesthetica | 10.62 | 9.93 | 10 | 223361 | 516 | 79520501 |
Tendinous contracture | 10.52 | 9.93 | 6 | 223365 | 140 | 79520877 |
Retrograde ejaculation | 10.52 | 9.93 | 8 | 223363 | 307 | 79520710 |
Rectocele repair | 10.51 | 9.93 | 3 | 223368 | 9 | 79521008 |
Cycloplegia | 10.51 | 9.93 | 3 | 223368 | 9 | 79521008 |
Arthroscopy | 10.50 | 9.93 | 10 | 223361 | 524 | 79520493 |
Device leakage | 10.45 | 9.93 | 9 | 223362 | 10847 | 79510170 |
Hepatic function abnormal | 10.44 | 9.93 | 143 | 223228 | 72964 | 79448053 |
Mental impairment | 10.44 | 9.93 | 90 | 223281 | 18946 | 79502071 |
Pulmonary alveolar haemorrhage | 10.43 | 9.93 | 10 | 223361 | 11447 | 79509570 |
Communication disorder | 10.34 | 9.93 | 30 | 223341 | 4060 | 79516957 |
Systemic candida | 10.28 | 9.93 | 3 | 223368 | 6703 | 79514314 |
Narcissistic personality disorder | 10.27 | 9.93 | 3 | 223368 | 10 | 79521007 |
Therapeutic response unexpected | 10.26 | 9.93 | 93 | 223278 | 19853 | 79501164 |
Cephalo-pelvic disproportion | 10.23 | 9.93 | 6 | 223365 | 148 | 79520869 |
Injury | 10.22 | 9.93 | 154 | 223217 | 77342 | 79443675 |
Activated partial thromboplastin time prolonged | 10.20 | 9.93 | 15 | 223356 | 14213 | 79506804 |
Tachyphylaxis | 10.17 | 9.93 | 8 | 223363 | 323 | 79520694 |
Bipolar I disorder | 10.17 | 9.93 | 20 | 223351 | 2109 | 79518908 |
Hydronephrosis | 10.15 | 9.93 | 21 | 223350 | 17433 | 79503584 |
Hepatic failure | 10.14 | 9.93 | 116 | 223255 | 61096 | 79459921 |
Pulmonary hypertension | 10.11 | 9.93 | 86 | 223285 | 47994 | 79473023 |
Staphylococcal sepsis | 10.10 | 9.93 | 16 | 223355 | 14710 | 79506307 |
Physical assault | 10.06 | 9.93 | 17 | 223354 | 1594 | 79519423 |
Sciatic nerve neuropathy | 10.02 | 9.93 | 9 | 223362 | 437 | 79520580 |
Suspected suicide attempt | 10.02 | 9.93 | 8 | 223363 | 330 | 79520687 |
Gastric ulcer | 9.93 | 9.93 | 55 | 223316 | 33850 | 79487167 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Telangiectasia congenital | 30.47 | 28.20 | 9 | 373 | 18 | 89392 |
Liver disorder | 29.80 | 28.20 | 8 | 374 | 9 | 89401 |
Source | Code | Description |
---|---|---|
ATC | N06AX21 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018689 | Sensory System Agents |
MeSH PA | D000068760 | Serotonin and Noradrenaline Reuptake Inhibitors |
FDA EPC | N0000175749 | Serotonin and Norepinephrine Reuptake Inhibitor |
CHEBI has role | CHEBI:35469 | antidepressants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Female stress incontinence | indication | 60241006 | DOID:724 |
Fibromyalgia | indication | 203082005 | DOID:631 |
Major depressive disorder | indication | 370143000 | |
Diabetic peripheral neuropathy | indication | 424736006 | |
Chronic Musculoskeletal Pain | indication | ||
Osteoarthritis | off-label use | 396275006 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Jaundice | contraindication | 18165001 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Orthostatic hypotension | contraindication | 28651003 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Alcoholic liver damage | contraindication | 41309000 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Chronic hepatitis | contraindication | 76783007 | DOID:2237 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Inflammatory disease of liver | contraindication | 128241005 | |
Liver function tests abnormal | contraindication | 166603001 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Serotonin syndrome | contraindication | 371089000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastrointestinal hypomotility | contraindication | 421807004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.7 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 20MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
EQ 30MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
EQ 60MG BASE | CYMBALTA | LILLY | N021427 | Aug. 3, 2004 | RX | CAPSULE, DELAYED REL PELLETS | ORAL | April 20, 2023 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 9.62 | CHEMBL | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 8.22 | CHEMBL | CHEMBL | |||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.30 | PDSP | |||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 6.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.68 | PDSP | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 6 | IUPHAR | ||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 6.40 | IUPHAR | ||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.65 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 5.64 | PDSP | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.40 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.52 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.62 | CHEMBL | |||||
5-hydroxytryptamine receptor 1F | GPCR | Ki | 5.35 | PDSP | |||||
5-hydroxytryptamine receptor 1E | GPCR | Ki | 5.43 | PDSP | |||||
Serine hydroxymethyltransferase, mitochondrial | Enzyme | IC50 | 5.16 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 10.09 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 6.43 | CHEMBL | |||||
Transporter | Transporter | Ki | 8.52 | CHEMBL |
ID | Source |
---|---|
D01179 | KEGG_DRUG |
136434-34-9 | SECONDARY_CAS_RN |
4021477 | VANDF |
C0245561 | UMLSCUI |
CHEBI:31526 | CHEBI |
29E | PDB_CHEM_ID |
CHEMBL1175 | ChEMBL_ID |
CHEMBL1200328 | ChEMBL_ID |
DB00476 | DRUGBANK_ID |
D000068736 | MESH_DESCRIPTOR_UI |
60835 | PUBCHEM_CID |
202 | IUPHAR_LIGAND_ID |
7012 | INN_ID |
O5TNM5N07U | UNII |
476250 | RXNORM |
18760 | MMSL |
208014 | MMSL |
33554 | MMSL |
59319 | MMSL |
d05355 | MMSL |
008705 | NDDF |
008707 | NDDF |
407032004 | SNOMEDCT_US |
407033009 | SNOMEDCT_US |
426892003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3235 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3235 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3240 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3240 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3270 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | NDA | 36 sections |
Cymbalta | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3270 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | NDA | 36 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2890 | CAPSULE, DELAYED RELEASE PELLETS | 20 mg | ORAL | ANDA | 29 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2891 | CAPSULE, DELAYED RELEASE PELLETS | 30 mg | ORAL | ANDA | 29 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2892 | CAPSULE, DELAYED RELEASE PELLETS | 60 mg | ORAL | ANDA | 29 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8203 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8203 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8204 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8204 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8290 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8290 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6452 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6453 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6454 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 30 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7043 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7043 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7044 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7044 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7045 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7045 | CAPSULE, DELAYED RELEASE | 60 mg | ORAL | ANDA | 31 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-109 | CAPSULE, DELAYED RELEASE | 20 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |
Duloxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-110 | CAPSULE, DELAYED RELEASE | 30 mg | ORAL | ANDA | 30 sections |