duloxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 972 116539-59-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • yentreve
  • cymbalta
  • duloxetine
  • (S)-Duloxetine
  • duloxetine hydrochloride
  • duloxetine HCl
A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.
  • Molecular weight: 297.42
  • Formula: C18H19NOS
  • CLOGP: 4.26
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.88 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 8.57 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 3, 2004 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 4079.64 10.00 2008 236838 25186 63224990
Dysphoria 3522.88 10.00 1129 237717 3837 63246339
Affect lability 2782.04 10.00 1174 237672 9977 63240199
Irritability 2255.42 10.00 1434 237412 30260 63219916
Suicidal ideation 2034.84 10.00 1765 237081 60656 63189520
Agitation 1774.72 10.00 1603 237243 58154 63192022
Sensory disturbance 1314.97 10.00 751 238095 12921 63237255
Hyperhidrosis 1288.74 10.00 1798 237048 106038 63144138
Vertigo 1216.80 10.00 1306 237540 58581 63191595
Paraesthesia 1186.48 10.00 2121 236725 154845 63095331
Insomnia 1077.79 10.00 2450 236396 212802 63037374
Anxiety 1038.45 10.00 2430 236416 215111 63035065
Nightmare 818.41 10.00 635 238211 18559 63231617
Mood swings 750.53 10.00 591 238255 17657 63232519
Dizziness 694.02 10.00 3324 235522 426601 62823575
Pemphigus 672.85 10.00 3 238843 183723 63066453
Serotonin syndrome 643.81 10.00 660 238186 28022 63222154
Tremor 603.76 10.00 1453 237393 130786 63119390
Tinnitus 583.54 10.00 695 238151 34933 63215243
Lethargy 529.08 10.00 837 238009 55170 63195006
Glossodynia 507.04 10.00 45 238801 178831 63071345
Hypomania 481.50 10.00 299 238547 6031 63244145
Hand deformity 454.94 10.00 39 238807 159418 63090758
Confusional state 437.75 10.00 1905 236941 234475 63015701
Systemic lupus erythematosus 403.57 10.00 141 238705 208777 63041399
Alopecia 400.15 10.00 408 238438 337128 62913048
Contraindicated product administered 379.29 10.00 172 238674 217476 63032700
Pericarditis 365.09 10.00 36 238810 131543 63118633
Withdrawal syndrome 364.07 10.00 412 238434 19585 63230591
Synovitis 356.12 10.00 129 238717 186789 63063387
Wound 342.45 10.00 95 238751 163168 63087008
Headache 340.39 10.00 3756 235090 629485 62620691
Suicide attempt 328.20 10.00 715 238131 60203 63189973
Duodenal ulcer perforation 306.67 10.00 4 238842 87205 63162971
Maternal exposure during pregnancy 286.50 10.00 244 238602 219818 63030358
Arthropathy 285.84 10.00 277 238569 234515 63015661
Nausea 278.54 10.00 4631 234215 849840 62400336
Drug intolerance 277.20 10.00 459 238387 308202 62941974
Abdominal discomfort 276.45 10.00 490 238356 320395 62929781
Anti-cyclic citrullinated peptide antibody positive 274.79 10.00 52 238794 116160 63134016
Treatment failure 266.11 10.00 215 238631 198828 63051348
Depression 261.81 10.00 1442 237404 195050 63055126
Infusion related reaction 257.85 10.00 327 238519 245194 63004982
Discomfort 248.19 10.00 162 238684 167212 63082964
Completed suicide 246.72 10.00 1144 237702 144529 63105647
Feeling abnormal 242.28 10.00 1153 237693 147239 63102937
Stubbornness 241.26 10.00 79 238767 292 63249884
Febrile neutropenia 240.84 10.00 73 238773 118376 63131800
Swelling 223.39 10.00 436 238410 274942 62975234
Joint swelling 223.18 10.00 571 238275 327095 62923081
Neutropenia 221.72 10.00 199 238647 174806 63075370
Pyrexia 211.34 10.00 981 237865 469497 62780679
Disturbance in attention 211.09 10.00 453 238393 37736 63212440
Crying 209.56 10.00 341 238505 23002 63227174
Folliculitis 203.78 10.00 16 238830 70301 63179875
Rash 200.34 10.00 1263 237583 559608 62690568
Hypersensitivity 198.53 10.00 511 238335 292174 62958002
Helicobacter infection 190.76 10.00 56 238790 92729 63157447
Anaemia 187.93 10.00 527 238319 292903 62957273
Somnolence 182.40 10.00 1224 237622 177461 63072715
Mood altered 181.98 10.00 250 238596 14493 63235683
Muscle injury 180.88 10.00 18 238828 65327 63184849
Rheumatoid factor positive 177.12 10.00 49 238797 84357 63165819
Therapeutic product effect decreased 173.52 10.00 287 238559 192900 63057276
Sleep disorder due to general medical condition, insomnia type 173.16 10.00 5 238841 52212 63197964
Thinking abnormal 168.26 10.00 204 238642 10439 63239737
General physical health deterioration 167.50 10.00 314 238532 201088 63049088
Lower respiratory tract infection 166.88 10.00 151 238695 132156 63118020
Thrombocytopenia 166.32 10.00 194 238652 150963 63099213
Blister 159.19 10.00 152 238694 129662 63120514
Sleep disorder 158.78 10.00 668 238178 80898 63169278
C-reactive protein abnormal 150.74 10.00 5 238841 46091 63204085
Electric shock 147.33 10.00 80 238766 1240 63248936
Panic attack 143.59 10.00 282 238564 22049 63228127
Pancytopenia 143.38 10.00 94 238752 96839 63153337
Off label use 141.16 10.00 1743 237103 672719 62577457
Product use issue 135.29 10.00 404 238442 220116 63030060
Impaired healing 134.17 10.00 113 238733 102429 63147747
Anger 129.95 10.00 195 238651 12261 63237915
Depressed mood 128.97 10.00 388 238458 39803 63210373
Coordination abnormal 128.81 10.00 205 238641 13568 63236608
Memory impairment 128.03 10.00 749 238097 103509 63146667
Infection 121.23 10.00 448 238398 228725 63021451
Disease progression 118.15 10.00 174 238672 122584 63127592
Stomatitis 116.42 10.00 215 238631 138510 63111666
Abnormal behaviour 115.91 10.00 252 238594 21174 63229002
Fatigue 115.33 10.00 4249 234597 883779 62366397
Affective disorder 114.19 10.00 128 238718 6018 63244158
Acute kidney injury 110.03 10.00 563 238283 262852 62987324
Migraine 109.01 10.00 714 238132 102632 63147544
Fall 108.57 10.00 2075 236771 390259 62859917
Drug interaction 107.95 10.00 1327 237519 227804 63022372
Inappropriate antidiuretic hormone secretion 105.21 10.00 200 238646 15262 63234914
Malignant neoplasm progression 103.19 10.00 94 238752 82027 63168149
Tardive dyskinesia 103.17 10.00 143 238703 8359 63241817
Post-traumatic stress disorder 100.38 10.00 111 238735 5140 63245036
Multiple sclerosis 99.63 10.00 257 238589 24115 63226061
Platelet count decreased 97.40 10.00 180 238666 115942 63134234
Peripheral swelling 96.62 10.00 595 238251 265347 62984829
Drug ineffective 94.92 10.00 3105 235741 1041660 62208516
Ill-defined disorder 94.18 10.00 101 238745 81654 63168522
Hallucination 93.78 10.00 432 238414 54385 63195791
Multiple sclerosis relapse 89.66 10.00 391 238455 48087 63202089
Pneumonia aspiration 88.69 10.00 309 238537 34231 63215945
Gastrointestinal tube insertion 87.65 10.00 54 238792 1073 63249103
Coma 87.31 10.00 475 238371 63889 63186287
Somatic symptom disorder 86.08 10.00 75 238771 2585 63247591
Septic shock 85.23 10.00 75 238771 66554 63183622
Irritable bowel syndrome 85.10 10.00 111 238735 82301 63167875
Loss of consciousness 84.52 10.00 745 238101 117376 63132800
Dyspnoea 84.24 10.00 1872 236974 659441 62590735
Cardiac failure 84.16 10.00 128 238718 89014 63161162
Gastric bypass 83.77 10.00 63 238783 1754 63248422
Intentional product misuse 82.25 10.00 449 238397 60468 63189708
Product substitution issue 80.74 10.00 183 238663 15813 63234363
Aggression 79.33 10.00 231 238615 23267 63226909
Pulmonary fibrosis 78.27 10.00 26 238820 39783 63210393
Restless legs syndrome 77.39 10.00 197 238649 18334 63231842
Opsoclonus myoclonus 72.99 10.00 26 238820 131 63250045
White blood cell count abnormal 72.78 10.00 103 238743 6139 63244037
Abnormal dreams 72.75 10.00 137 238709 10379 63239797
Premature delivery 72.72 10.00 13 238833 30268 63219908
Reversible cerebral vasoconstriction syndrome 72.36 10.00 68 238778 2590 63247586
Gastrointestinal disorder 71.69 10.00 253 238593 130986 63119190
Nasal turbinate hypertrophy 70.90 10.00 41 238805 722 63249454
Myelosuppression 69.78 10.00 5 238841 23698 63226478
Personality disorder 69.40 10.00 97 238749 5714 63244462
Neutrophil count decreased 69.17 10.00 66 238780 56340 63193836
Hip arthroplasty 68.04 10.00 48 238798 47598 63202578
Influenza like illness 67.62 10.00 457 238389 66367 63183809
Erythema 67.60 10.00 386 238460 175365 63074811
Liver injury 67.25 10.00 77 238769 60443 63189733
Renal impairment 66.35 10.00 146 238700 88209 63161967
Lymphocytic oesophagitis 66.25 10.00 17 238829 17 63250159
Pneumonia 64.80 10.00 1270 237576 455497 62794679
Intervertebral discitis 64.77 10.00 70 238776 3158 63247018
Intentional self-injury 64.39 10.00 228 238618 25459 63224717
Vision blurred 64.31 10.00 577 238269 91347 63158829
Mania 64.11 10.00 143 238703 12224 63237952
Sleep apnoea syndrome 63.34 10.00 247 238599 28886 63221290
Leukopenia 62.00 10.00 123 238723 77167 63173009
Mobility decreased 61.96 10.00 240 238606 120919 63129257
Fibromyalgia 61.06 10.00 514 238332 79906 63170270
Pulmonary malformation 59.94 10.00 27 238819 272 63249904
Mucosal inflammation 59.80 10.00 53 238793 46875 63203301
Sepsis 59.58 10.00 335 238511 152788 63097388
Hyperreflexia 59.21 10.00 91 238755 5843 63244333
Alanine aminotransferase increased 59.17 10.00 624 238222 103146 63147030
Mental disorder 59.02 10.00 223 238623 25696 63224480
Hallucination, visual 58.81 10.00 183 238663 19115 63231061
Pleural effusion 58.37 10.00 169 238677 93041 63157135
Haemoglobin decreased 57.85 10.00 316 238530 145169 63105007
Colitis microscopic 57.70 10.00 116 238730 9223 63240953
Sopor 57.52 10.00 199 238647 21965 63228211
Blood creatinine increased 57.43 10.00 156 238690 87688 63162488
Live birth 57.39 10.00 13 238833 25617 63224559
Ascites 56.89 10.00 42 238804 40686 63209490
Seizure 56.39 10.00 754 238092 131880 63118296
White blood cell count decreased 55.94 10.00 301 238545 138803 63111373
Red blood cell sedimentation rate abnormal 55.93 10.00 5 238841 19777 63230399
Drug reaction with eosinophilia and systemic symptoms 55.42 10.00 29 238817 33807 63216369
Paranoia 54.98 10.00 130 238716 11549 63238627
Blood cholesterol increased 54.95 10.00 176 238670 93856 63156320
Hot flush 54.86 10.00 355 238491 50804 63199372
Product dose omission issue 54.68 10.00 1209 237637 233104 63017072
Blood pressure increased 53.89 10.00 883 237963 161179 63088997
Dyskinesia 53.84 10.00 251 238595 31751 63218425
Surgery 53.48 10.00 272 238574 35640 63214536
Cytomegalovirus infection 52.53 10.00 8 238838 20944 63229232
Bronchial neoplasm 52.21 10.00 29 238817 471 63249705
Amnesia 51.45 10.00 372 238474 55213 63194963
Temperature intolerance 51.44 10.00 108 238738 8856 63241320
Neutropenic sepsis 49.77 10.00 3 238843 16435 63233741
Urinary retention 49.76 10.00 236 238610 30065 63220111
Interstitial lung disease 49.24 10.00 99 238747 61809 63188367
Renal failure 48.74 10.00 252 238594 117400 63132776
Hyperaesthesia 48.28 10.00 108 238738 9250 63240926
Hyperkalaemia 48.16 10.00 81 238765 54122 63196054
Bronchial haemorrhage 47.66 10.00 29 238817 563 63249613
Lung cyst 47.38 10.00 24 238822 320 63249856
Restlessness 47.36 10.00 228 238618 29225 63220951
Extremity contracture 47.26 10.00 39 238807 1246 63248930
Coma blister 47.19 10.00 19 238827 141 63250035
Rheumatoid nodule 46.76 10.00 5 238841 17150 63233026
Bone marrow failure 46.66 10.00 26 238820 29264 63220912
Hypocalcaemia 46.54 10.00 31 238815 31682 63218494
Oesophageal spasm 46.36 10.00 58 238788 3065 63247111
Neck deformity 46.11 10.00 48 238798 2073 63248103
Intentional product use issue 44.39 10.00 290 238556 127602 63122574
Multiple organ dysfunction syndrome 44.08 10.00 92 238754 56660 63193516
Psoriasis 43.67 10.00 510 238336 86447 63163729
Condition aggravated 43.53 10.00 1166 237680 401051 62849125
Balance disorder 43.23 10.00 497 238349 83925 63166251
Drug tolerance decreased 43.06 10.00 7 238839 17466 63232710
Macular degeneration 42.81 10.00 19 238827 24357 63225819
Rubber sensitivity 42.37 10.00 48 238798 2283 63247893
Atrial fibrillation 42.27 10.00 261 238585 116375 63133801
Nervousness 42.25 10.00 229 238617 30750 63219426
Muscle twitching 42.14 10.00 166 238680 19502 63230674
Therapy interrupted 41.65 10.00 236 238610 32219 63217957
Device expulsion 41.50 10.00 42 238804 34880 63215296
Neck mass 41.34 10.00 59 238787 3544 63246632
Endometrial ablation 41.31 10.00 32 238814 932 63249244
Neurologic neglect syndrome 41.14 10.00 51 238795 2670 63247506
Neoplasm progression 40.84 10.00 46 238800 36382 63213794
Oedema peripheral 40.82 10.00 486 238360 189025 63061151
Gastrointestinal haemorrhage 40.72 10.00 162 238684 81014 63169162
Respiratory tract malformation 40.52 10.00 18 238828 175 63250001
Pruritus 40.37 10.00 1043 237803 360410 62889766
Carotid artery thrombosis 40.06 10.00 51 238795 2743 63247433
Vomiting 40.05 10.00 2527 236319 557090 62693086
Pre-existing condition improved 39.06 10.00 92 238754 8152 63242024
Therapy cessation 38.78 10.00 221 238625 30236 63219940
Lip dry 38.57 10.00 6 238840 15464 63234712
Dissociation 38.30 10.00 51 238795 2868 63247308
Aspartate aminotransferase increased 37.86 10.00 512 238334 89765 63160411
Type 2 diabetes mellitus 37.69 10.00 119 238727 63749 63186427
Disorientation 37.65 10.00 266 238580 39186 63210990
Hypersomnia 37.57 10.00 151 238695 17904 63232272
Concussion 37.29 10.00 97 238749 9147 63241029
Tachyphrenia 37.11 10.00 35 238811 1339 63248837
Rapid eye movements sleep abnormal 37.09 10.00 16 238830 144 63250032
Skin haemorrhage 36.77 10.00 102 238744 9992 63240184
Hostility 36.52 10.00 40 238806 1832 63248344
Major depression 36.39 10.00 88 238758 7930 63242246
Knee arthroplasty 36.38 10.00 95 238751 54111 63196065
Therapy non-responder 35.88 10.00 155 238691 75746 63174430
Metabolic surgery 35.60 10.00 33 238813 1235 63248941
Complex regional pain syndrome 35.35 10.00 44 238802 2313 63247863
Rebound nasal congestion 34.96 10.00 10 238836 20 63250156
Blood calcium decreased 34.76 10.00 29 238817 26422 63223754
Inflammation 34.76 10.00 175 238671 82098 63168078
Death 34.55 10.00 1109 237737 373272 62876904
Palmar-plantar erythrodysaesthesia syndrome 34.45 10.00 22 238824 22993 63227183
Cardiac failure congestive 34.45 10.00 205 238641 92228 63157948
Adverse event 34.41 10.00 134 238712 67425 63182751
Lactic acidosis 34.21 10.00 57 238789 38230 63211946
Morbid thoughts 34.18 10.00 24 238822 599 63249577
Pulmonary oedema 33.98 10.00 100 238746 54773 63195403
Libido increased 33.94 10.00 33 238813 1312 63248864
Akathisia 33.89 10.00 93 238753 9053 63241123
Speech disorder 33.70 10.00 265 238581 40364 63209812
Bruxism 33.69 10.00 53 238793 3472 63246704
Bipolar disorder 33.63 10.00 85 238761 7875 63242301
Formication 33.61 10.00 59 238787 4232 63245944
Neuralgia 33.58 10.00 189 238657 25737 63224439
Product use in unapproved indication 33.49 10.00 473 238373 178607 63071569
Anovulatory cycle 33.14 10.00 15 238831 153 63250023
Impaired driving ability 32.75 10.00 60 238786 4451 63245725
Sacroiliitis 32.57 10.00 50 238796 3207 63246969
Head injury 31.79 10.00 194 238652 27202 63222974
Post cholecystectomy syndrome 31.53 10.00 20 238826 419 63249757
Drug abuse 31.53 10.00 414 238432 72104 63178072
Hypomagnesaemia 31.45 10.00 37 238809 28700 63221476
Dysphagia 31.43 10.00 488 238358 88097 63162079
Stiff person syndrome 31.27 10.00 18 238828 314 63249862
Tearfulness 31.25 10.00 56 238790 4083 63246093
Dry mouth 31.18 10.00 438 238408 77425 63172751
Decompression sickness 31.15 10.00 12 238834 78 63250098
Libido decreased 31.02 10.00 44 238802 2628 63247548
Rash maculo-papular 30.87 10.00 45 238801 31851 63218325
C-reactive protein increased 30.75 10.00 219 238627 94488 63155688
Adjustment disorder 30.68 10.00 48 238798 3130 63247046
Hypoventilation 30.51 10.00 60 238786 4694 63245482
Hypnopompic hallucination 30.47 10.00 11 238835 58 63250118
Delusion 30.40 10.00 107 238739 11910 63238266
Anorgasmia 30.25 10.00 22 238824 581 63249595
Respiratory failure 30.01 10.00 242 238604 101616 63148560
Product tampering 29.92 10.00 19 238827 399 63249777
Transplant rejection 29.75 10.00 3 238843 10777 63239399
Gastrooesophageal reflux disease 29.54 10.00 515 238331 95124 63155052
Skin necrosis 29.44 10.00 8 238838 13942 63236234
Demyelination 29.35 10.00 74 238772 6846 63243330
Melaena 29.23 10.00 43 238803 30322 63219854
Psychotic disorder 29.16 10.00 181 238665 25531 63224645
Psychotic disorder due to a general medical condition 28.80 10.00 16 238830 260 63249916
Thunderclap headache 28.60 10.00 15 238831 216 63249960
Intentional overdose 28.44 10.00 414 238432 73738 63176438
Bone density abnormal 28.29 10.00 48 238798 3350 63246826
Oedema 28.27 10.00 233 238613 97389 63152787
Sensitivity to weather change 28.23 10.00 75 238771 7162 63243014
Middle insomnia 28.14 10.00 108 238738 12535 63237641
Phagophobia 27.98 10.00 10 238836 51 63250125
Telangiectasia congenital 27.96 10.00 8 238838 16 63250160
Emotional disorder 27.92 10.00 112 238734 13267 63236909
Agranulocytosis 27.89 10.00 32 238814 25102 63225074
Psychomotor hyperactivity 27.89 10.00 96 238750 10567 63239609
Gastric banding 27.87 10.00 11 238835 77 63250099
Epistaxis 27.79 10.00 160 238686 72565 63177611
Lung disorder 27.71 10.00 130 238716 62131 63188045
Hypotension 27.71 10.00 797 238049 271807 62978369
Bronchial disorder 27.70 10.00 29 238817 1261 63248915
Acute myeloid leukaemia 27.63 10.00 15 238831 17132 63233044
Pregnancy 27.54 10.00 61 238785 36775 63213401
Pulmonary eosinophilia 27.49 10.00 17 238829 340 63249836
Blood immunoglobulin A increased 27.34 10.00 23 238823 755 63249421
Therapeutic response changed 27.05 10.00 26 238820 1019 63249157
Loss of libido 26.62 10.00 29 238817 1320 63248856
Depressive symptom 26.61 10.00 52 238794 4050 63246126
Oesophageal pain 26.58 10.00 49 238797 3652 63246524
Thrombotic microangiopathy 26.55 10.00 4 238842 10557 63239619
Metastases to bone 26.46 10.00 24 238822 20995 63229181
Apathy 26.43 10.00 83 238763 8711 63241465
Arthralgia 26.42 10.00 1817 237029 567893 62682283
Ankle fracture 26.42 10.00 135 238711 17720 63232456
Ejection fraction decreased 26.37 10.00 27 238819 22305 63227871
Muscular weakness 26.23 10.00 624 238222 121729 63128447
Bradycardia 25.93 10.00 165 238681 73062 63177114
Gastrostomy 25.93 10.00 21 238825 653 63249523
Red blood cell sedimentation rate increased 25.91 10.00 82 238764 43900 63206276
Autonomic dysreflexia 25.88 10.00 16 238830 320 63249856
Decreased interest 25.83 10.00 45 238801 3209 63246967
Mydriasis 25.69 10.00 101 238745 11855 63238321
Tenosynovitis 25.43 10.00 10 238836 13785 63236391
Joint noise 25.30 10.00 53 238793 4339 63245837
Proteinuria 25.15 10.00 21 238825 19124 63231052
Bone erosion 25.09 10.00 18 238828 17699 63232477
Spinal operation 24.80 10.00 78 238768 8193 63241983
Exposure during pregnancy 24.62 10.00 424 238422 155123 63095053
Drug resistance 24.59 10.00 30 238816 22903 63227273
Cognitive disorder 24.41 10.00 319 238527 55496 63194680
Aspartate aminotransferase 24.36 10.00 17 238829 420 63249756
Adulterated product 24.34 10.00 14 238832 244 63249932
Peripheral venous disease 24.28 10.00 14 238832 15463 63234713
Toxicity to various agents 24.25 10.00 1150 237696 246100 63004076
Tension 24.03 10.00 43 238803 3132 63247044
Genital pain 23.87 10.00 17 238829 434 63249742
Galactorrhoea 23.77 10.00 50 238796 4105 63246071
Gait disturbance 23.63 10.00 877 237969 182301 63067875
Homicidal ideation 23.59 10.00 31 238815 1721 63248455
Tubulointerstitial nephritis 23.57 10.00 24 238822 19879 63230297
Weight increased 23.49 10.00 1203 237643 259589 62990587
Hallucination, auditory 23.37 10.00 103 238743 12721 63237455
Flat affect 23.26 10.00 28 238818 1422 63248754
Aplastic anaemia 23.21 10.00 4 238842 9565 63240611
Antinuclear antibody negative 22.88 10.00 13 238833 221 63249955
Depression suicidal 22.62 10.00 31 238815 1792 63248384
Glomerular filtration rate increased 22.60 10.00 22 238824 876 63249300
Haematotoxicity 22.57 10.00 4 238842 9372 63240804
Creatinine renal clearance decreased 22.54 10.00 17 238829 16291 63233885
Lupus-like syndrome 22.38 10.00 15 238831 15280 63234896
Drug screen positive 22.33 10.00 45 238801 3584 63246592
Metastases to liver 22.25 10.00 34 238812 23605 63226571
Deep vein thrombosis 22.06 10.00 205 238641 83595 63166581
Coombs positive haemolytic anaemia 22.02 10.00 15 238831 356 63249820
Acute respiratory distress syndrome 22.00 10.00 34 238812 23500 63226676
Poisoning 21.98 10.00 106 238740 13594 63236582
Haemoptysis 21.94 10.00 47 238799 28679 63221497
Hypercalcaemia 21.92 10.00 46 238800 28276 63221900
Poor sucking reflex 21.88 10.00 14 238832 298 63249878
Hepatotoxicity 21.86 10.00 69 238777 36972 63213204
Toxic epidermal necrolysis 21.47 10.00 39 238807 25295 63224881
Disseminated intravascular coagulation 21.42 10.00 24 238822 19027 63231149
Granulomatous liver disease 21.36 10.00 20 238826 758 63249418
Contusion 21.25 10.00 417 238429 149627 63100549
Alcoholism 21.20 10.00 30 238816 1788 63248388
Exposure via breast milk 21.17 10.00 32 238814 2025 63248151
Blood alkaline phosphatase increased 21.12 10.00 251 238595 42716 63207460
Dehydration 21.00 10.00 494 238352 172860 63077316
Cerebral infarction 20.95 10.00 36 238810 23857 63226319
Sinus disorder 20.83 10.00 161 238685 24392 63225784
Pulmonary toxicity 20.76 10.00 5 238841 9450 63240726
Muscle spasms 20.72 10.00 750 238096 155400 63094776
Pulmonary congestion 20.63 10.00 21 238825 17397 63232779
Facet joint syndrome 20.48 10.00 10 238836 12128 63238048
Conversion disorder 20.41 10.00 29 238817 1735 63248441
Basal cell carcinoma 20.40 10.00 47 238799 27944 63222232
Clonus 20.10 10.00 50 238796 4586 63245590
Myelodysplastic syndrome 20.08 10.00 20 238826 16734 63233442
Shock 19.99 10.00 36 238810 23427 63226749
Spinal disorder 19.96 10.00 82 238764 9820 63240356
Arteriosclerosis coronary artery 19.86 10.00 73 238773 8300 63241876
Overdose 19.76 10.00 570 238276 114508 63135668
Cytokine release syndrome 19.68 10.00 15 238831 14299 63235877
Sedation complication 19.63 10.00 14 238832 13808 63236368
Poor quality sleep 19.36 10.00 135 238711 19800 63230376
Coronary artery disease 19.33 10.00 60 238786 32317 63217859
Intervertebral disc protrusion 19.31 10.00 154 238692 23555 63226621
Bradyphrenia 19.28 10.00 64 238782 6916 63243260
Asphyxia 19.19 10.00 59 238787 6122 63244054
Hepatic enzyme increased 19.19 10.00 597 238249 201731 63048445
Hyperacusis 19.14 10.00 31 238815 2082 63248094
Granulocyte count increased 19.13 10.00 20 238826 868 63249308
Tic 19.09 10.00 26 238820 1494 63248682
Lactation disorder 19.05 10.00 14 238832 376 63249800
Urinary incontinence 18.93 10.00 194 238652 31820 63218356
Myoclonus 18.81 10.00 113 238733 15755 63234421
Cystitis 18.77 10.00 301 238545 54690 63195486
Dysphemia 18.69 10.00 35 238811 2640 63247536
Premature labour 18.65 10.00 12 238834 12492 63237684
Carcinoid tumour pulmonary 18.62 10.00 15 238831 463 63249713
Injury 18.50 10.00 181 238665 73066 63177110
Breast cancer stage II 18.45 10.00 5 238841 8731 63241445
Circulatory collapse 18.38 10.00 34 238812 21904 63228272
Dyspnoea exertional 18.35 10.00 142 238704 60160 63190016
Feelings of worthlessness 18.29 10.00 13 238833 331 63249845
Bacteraemia 18.28 10.00 23 238823 17325 63232851
Pneumocystis jirovecii pneumonia 18.27 10.00 22 238824 16892 63233284
Feeling of despair 18.11 10.00 32 238814 2307 63247869
Pustular psoriasis 18.10 10.00 48 238798 4578 63245598
Nasopharyngitis 18.08 10.00 777 238069 253480 62996696
Hypoalbuminaemia 18.06 10.00 11 238835 11794 63238382
Dactylitis 18.03 10.00 34 238812 2578 63247598
Ophthalmic vein thrombosis 18.01 10.00 11 238835 215 63249961
Drug eruption 17.97 10.00 52 238794 28642 63221534
Right ventricular failure 17.89 10.00 23 238823 17165 63233011
Panic disorder 17.84 10.00 34 238812 2599 63247577
CYP3A4 polymorphism 17.81 10.00 8 238838 80 63250096
Progressive multifocal leukoencephalopathy 17.76 10.00 96 238750 12875 63237301
Sinus congestion 17.76 10.00 123 238723 18000 63232176
Eosinophilia 17.58 10.00 37 238809 22719 63227457
Respiratory distress 17.51 10.00 67 238779 33884 63216292
Liver function test increased 17.41 10.00 64 238782 32747 63217429
Impulse-control disorder 17.39 10.00 18 238828 772 63249404
Bipolar I disorder 17.39 10.00 28 238818 1871 63248305
Haemodialysis 17.31 10.00 6 238840 8941 63241235
Cholestasis 17.25 10.00 55 238791 29379 63220797
Sleep talking 17.24 10.00 20 238826 976 63249200
Dopamine transporter scintigraphy abnormal 17.22 10.00 8 238838 87 63250089
Rhonchi 17.13 10.00 33 238813 2543 63247633
Toxic skin eruption 17.09 10.00 14 238832 12871 63237305
Priapism 17.07 10.00 9 238837 131 63250045
Panic reaction 17.04 10.00 44 238802 4130 63246046
Claustrophobia 16.89 10.00 20 238826 998 63249178
Vitamin B12 increased 16.83 10.00 21 238825 1107 63249069
Hyponatraemic encephalopathy 16.75 10.00 11 238835 245 63249931
Hypokalaemia 16.73 10.00 282 238564 103522 63146654
Cardiogenic shock 16.67 10.00 26 238820 17906 63232270
Pulseless electrical activity 16.47 10.00 4 238842 7517 63242659
Metastases to central nervous system 16.46 10.00 15 238831 13090 63237086
Scoliosis 16.44 10.00 66 238780 7822 63242354
Aspergillus infection 16.42 10.00 5 238841 8088 63242088
Tuberculosis 16.39 10.00 11 238835 11200 63238976
Adjustment disorder with depressed mood 16.34 10.00 9 238837 10195 63239981
Feeling drunk 16.23 10.00 43 238803 4099 63246077
Autonomic nervous system imbalance 16.23 10.00 34 238812 2784 63247392
Transfusion 16.22 10.00 20 238826 15197 63234979
Oliguria 16.13 10.00 7 238839 9094 63241082
Diplopia 16.10 10.00 148 238698 23580 63226596
Fear 16.04 10.00 108 238738 15658 63234518
Second primary malignancy 15.98 10.00 5 238841 7948 63242228
Aphasia 15.88 10.00 192 238654 32808 63217368
Oesophageal food impaction 15.87 10.00 10 238836 207 63249969
Obsessive thoughts 15.86 10.00 15 238831 576 63249600
Hypoxia 15.85 10.00 146 238700 59646 63190530
Ischaemic stroke 15.80 10.00 27 238819 17930 63232246
Rectal haemorrhage 15.61 10.00 114 238732 48916 63201260
Post-traumatic neck syndrome 15.58 10.00 28 238818 2046 63248130
Metastases to lung 15.53 10.00 15 238831 12735 63237441
Intrusive thoughts 15.42 10.00 10 238836 218 63249958
Pneumonitis 15.40 10.00 74 238772 35148 63215028
Bronchiectasis 15.40 10.00 23 238823 16119 63234057
Hypoaesthesia 15.40 10.00 778 238068 167615 63082561
Decreased appetite 15.29 10.00 780 238066 250272 62999904
Mean cell haemoglobin concentration increased 15.26 10.00 14 238832 517 63249659
Rheumatoid factor increased 15.24 10.00 26 238820 1823 63248353
Self-injurious ideation 15.22 10.00 32 238814 2627 63247549
Meralgia paraesthetica 15.17 10.00 13 238833 438 63249738
Blood lactate dehydrogenase increased 15.14 10.00 41 238805 23075 63227101
Gambling disorder 15.10 10.00 21 238825 1231 63248945
Cataplexy 15.05 10.00 21 238825 1235 63248941
Naevus flammeus 15.02 10.00 8 238838 119 63250057
Total cholesterol/HDL ratio abnormal 15.00 10.00 7 238839 77 63250099
Hepatic steatosis 15 10.00 170 238676 28599 63221577
Scar 14.99 10.00 96 238750 13686 63236490
Drug hypersensitivity 14.93 10.00 1360 237486 309327 62940849
Food aversion 14.83 10.00 17 238829 819 63249357
Wound infection 14.77 10.00 37 238809 21373 63228803
Liver disorder 14.71 10.00 130 238716 53557 63196619
Hypervolaemia 14.69 10.00 56 238790 28357 63221819
Eating disorder 14.67 10.00 122 238724 18894 63231282
Impatience 14.66 10.00 12 238834 379 63249797
Respiratory tract congestion 14.62 10.00 116 238730 17716 63232460
Somnambulism 14.58 10.00 50 238796 5493 63244683
Vasculitis 14.58 10.00 29 238817 18180 63231996
Myofascial pain syndrome 14.57 10.00 29 238817 2289 63247887
Heart rate decreased 14.47 10.00 106 238740 45454 63204722
Mental impairment 14.44 10.00 97 238749 14054 63236122
Anaphylactic reaction 14.41 10.00 169 238677 65931 63184245
Cushingoid 14.30 10.00 7 238839 8478 63241698
Tumour lysis syndrome 14.29 10.00 8 238838 8982 63241194
Rales 14.27 10.00 16 238830 12681 63237495
Device related infection 14.21 10.00 43 238803 23349 63226827
Accidental exposure to product 14.18 10.00 54 238792 27351 63222825
Hypnagogic hallucination 14.13 10.00 9 238837 190 63249986
Hypoglycaemia 14.11 10.00 151 238695 59914 63190262
Vitamin B12 deficiency 14.09 10.00 48 238798 5255 63244921
Spondyloarthropathy 14.02 10.00 17 238829 870 63249306
Hyperglycaemia 13.98 10.00 96 238750 41771 63208405
Enterococcal infection 13.97 10.00 6 238840 7842 63242334
Deformity 13.94 10.00 14 238832 11670 63238506
Pseudomonas infection 13.88 10.00 13 238833 11200 63238976
Lung diffusion test decreased 13.77 10.00 15 238831 683 63249493
Clitoral engorgement 13.76 10.00 3 238843 0 63250176
Phobia of driving 13.76 10.00 3 238843 0 63250176
Tachyphylaxis 13.69 10.00 10 238836 266 63249910
Heat exhaustion 13.68 10.00 8 238838 144 63250032
Maternal exposure during breast feeding 13.65 10.00 41 238805 4200 63245976
Motor dysfunction 13.64 10.00 78 238768 10683 63239493
Drug-induced liver injury 13.55 10.00 92 238754 40130 63210046
Hepatobiliary scan abnormal 13.45 10.00 6 238840 59 63250117
Rotator cuff syndrome 13.45 10.00 92 238754 13410 63236766
Gun shot wound 13.44 10.00 8 238838 149 63250027
Metastases to lymph nodes 13.35 10.00 7 238839 8151 63242025
Intentional dose omission 13.33 10.00 63 238783 8012 63242164
Leukopenia neonatal 13.32 10.00 5 238841 30 63250146
Holmes-Adie pupil 13.32 10.00 5 238841 30 63250146
Soft tissue injury 13.31 10.00 23 238823 1629 63248547
Trigeminal neuralgia 13.25 10.00 36 238810 3483 63246693
Hepatitis C antibody positive 13.21 10.00 7 238839 103 63250073
Dysarthria 13.18 10.00 230 238616 42481 63207695
Immobilisation prolonged 13.15 10.00 7 238839 104 63250072
Generalised anxiety disorder 13.10 10.00 26 238820 2048 63248128
Progressive multiple sclerosis 13.09 10.00 19 238827 1159 63249017
Sleep-related eating disorder 12.95 10.00 16 238830 835 63249341
Palpitations 12.91 10.00 533 238313 112237 63137939
Caesarean section 12.90 10.00 28 238818 17004 63233172
Pathogen resistance 12.89 10.00 4 238842 6394 63243782
Drug metabolising enzyme decreased 12.85 10.00 4 238842 12 63250164
Sensory loss 12.84 10.00 74 238772 10164 63240012
Radiation fibrosis 12.79 10.00 5 238841 34 63250142
Torsade de pointes 12.76 10.00 19 238827 13332 63236844
Sternal fracture 12.75 10.00 27 238819 2227 63247949
Intervertebral disc operation 12.71 10.00 16 238830 851 63249325
Breast cancer stage I 12.69 10.00 5 238841 6884 63243292
Gastric ulcer 12.68 10.00 47 238799 23990 63226186
Pulmonary arterial hypertension 12.67 10.00 43 238803 22534 63227642
Acute myocardial infarction 12.63 10.00 70 238776 32054 63218122
Anaphylactic shock 12.60 10.00 46 238800 23587 63226589
Drug ineffective for unapproved indication 12.60 10.00 189 238657 33874 63216302
Abdominal pain 12.57 10.00 942 237904 292514 62957662
Musculoskeletal stiffness 12.53 10.00 567 238279 184051 63066125
Foot deformity 12.48 10.00 58 238788 27795 63222381
Food craving 12.47 10.00 22 238824 1584 63248592
Ear pain 12.47 10.00 82 238764 36036 63214140
Device difficult to use 12.43 10.00 18 238828 12778 63237398
Autoimmune disorder 12.39 10.00 29 238817 17148 63233028
Cytomegalovirus viraemia 12.38 10.00 3 238843 5646 63244530
Urinary hesitation 12.38 10.00 27 238819 2273 63247903
Breast cancer female 12.29 10.00 20 238826 13539 63236637
Polyarthritis 12.29 10.00 12 238834 10134 63240042
Menopausal symptoms 12.25 10.00 28 238818 2433 63247743
Eye pain 12.19 10.00 187 238659 33667 63216509
Foetal death 12.16 10.00 14 238832 10966 63239210
Suspected suicide 12.16 10.00 53 238793 6515 63243661
Nephrotic syndrome 12.14 10.00 3 238843 5573 63244603
Adverse drug reaction 12.06 10.00 219 238627 79495 63170681
Snoring 12.03 10.00 39 238807 4163 63246013
Atelectasis 12.00 10.00 41 238805 21442 63228734
Pulmonary haemorrhage 11.99 10.00 6 238840 7175 63243001
Spasmodic dysphonia 11.98 10.00 6 238840 78 63250098
Sinus pain 11.97 10.00 34 238812 3376 63246800
Pulmonary hypertension 11.97 10.00 86 238760 37037 63213139
Bone density decreased 11.93 10.00 23 238823 14589 63235587
Polyneuropathy 11.88 10.00 23 238823 14566 63235610
Haematuria 11.76 10.00 63 238783 29094 63221082
Vitamin D deficiency 11.73 10.00 91 238755 13801 63236375
Sluggishness 11.72 10.00 45 238801 5224 63244952
Proctitis 11.71 10.00 3 238843 5438 63244738
Chronic idiopathic pain syndrome 11.69 10.00 3 238843 3 63250173
Intestinal intraepithelial lymphocytes increased 11.69 10.00 3 238843 3 63250173
Increased appetite 11.69 10.00 69 238777 9561 63240615
Sciatic nerve injury 11.65 10.00 12 238834 512 63249664
Shock haemorrhagic 11.64 10.00 12 238834 9883 63240293
Epstein-Barr virus infection 11.64 10.00 8 238838 8042 63242134
Neuropathy peripheral 11.62 10.00 531 238315 113136 63137040
Respiratory tract infection 11.56 10.00 100 238746 41383 63208793
Metabolic acidosis 11.54 10.00 111 238735 44958 63205218
Supraventricular tachyarrhythmia 11.53 10.00 6 238840 85 63250091
Knee operation 11.50 10.00 49 238797 5964 63244212
Polyglandular autoimmune syndrome type II 11.49 10.00 5 238841 46 63250130
Serum serotonin increased 11.49 10.00 8 238838 197 63249979
Economic problem 11.48 10.00 24 238822 1962 63248214
Uraemic encephalopathy 11.45 10.00 9 238837 268 63249908
Impulsive behaviour 11.42 10.00 21 238825 1562 63248614
Labelled drug-food interaction issue 11.42 10.00 4 238842 19 63250157
Abortion induced 11.41 10.00 13 238833 10229 63239947
Cardiotoxicity 11.40 10.00 9 238837 8429 63241747
Dystonia 11.38 10.00 90 238756 13729 63236447
Escherichia infection 11.38 10.00 19 238827 12735 63237441
Suspected suicide attempt 11.37 10.00 7 238839 139 63250037
Alcohol abuse 11.33 10.00 25 238821 2121 63248055
Retching 11.32 10.00 94 238752 14551 63235625
Purple glove syndrome 11.21 10.00 8 238838 205 63249971
Persistent genital arousal disorder 11.19 10.00 9 238837 277 63249899
Posterior reversible encephalopathy syndrome 11.18 10.00 31 238815 17314 63232862
Phonophobia 11.16 10.00 10 238836 358 63249818
Genital ulceration 11.09 10.00 13 238833 642 63249534
Skin plaque 11.08 10.00 9 238837 8311 63241865
Pyometra 11.05 10.00 6 238840 93 63250083
Alveolar bone resorption 11.05 10.00 5 238841 51 63250125
Ventricular hypoplasia 11.02 10.00 7 238839 147 63250029
Osteonecrosis of jaw 11.02 10.00 82 238764 35041 63215135
Neck pain 10.99 10.00 340 238506 68978 63181198
Suicidal behaviour 10.96 10.00 28 238818 2611 63247565
Reaction to azo-dyes 10.94 10.00 4 238842 22 63250154
Trigger finger 10.94 10.00 39 238807 4369 63245807
Drug screen negative 10.92 10.00 9 238837 287 63249889
Feeling jittery 10.88 10.00 87 238759 13316 63236860
Accommodation disorder 10.86 10.00 10 238836 371 63249805
Herpes simplex reactivation 10.84 10.00 12 238834 556 63249620
Multiple-drug resistance 10.84 10.00 3 238843 5167 63245009
Suspected product quality issue 10.82 10.00 8 238838 217 63249959
Hemiplegia 10.80 10.00 66 238780 9257 63240919
Pulse abnormal 10.79 10.00 26 238820 2338 63247838
Antiphospholipid syndrome 10.78 10.00 22 238824 1768 63248408
Status epilepticus 10.76 10.00 26 238820 15207 63234969
Drug withdrawal syndrome neonatal 10.72 10.00 24 238822 2057 63248119
Forced expiratory volume decreased 10.70 10.00 42 238804 4926 63245250
Electric shock sensation 10.70 10.00 14 238832 774 63249402
Acute pulmonary oedema 10.65 10.00 9 238837 8149 63242027
Ligament injury 10.62 10.00 17 238829 1130 63249046
Lung neoplasm malignant 10.61 10.00 38 238808 19595 63230581
Occipital neuralgia 10.59 10.00 11 238835 474 63249702
Unintended pregnancy 10.56 10.00 5 238841 6174 63244002
Klebsiella infection 10.53 10.00 10 238836 8556 63241620
Clumsiness 10.52 10.00 24 238822 2083 63248093
Rheumatoid arthritis 10.51 10.00 817 238029 253002 62997174
Hepatitis A antibody positive 10.48 10.00 5 238841 58 63250118
Adiposis dolorosa 10.48 10.00 9 238837 304 63249872
Congenital tricuspid valve atresia 10.46 10.00 6 238840 104 63250072
Foot amputation 10.46 10.00 9 238837 305 63249871
Antidepressant drug level increased 10.41 10.00 9 238837 307 63249869
Borderline personality disorder 10.38 10.00 14 238832 797 63249379
Hydronephrosis 10.36 10.00 15 238831 10647 63239529
Central nervous system lesion 10.32 10.00 72 238774 10563 63239613
Violence-related symptom 10.28 10.00 10 238836 398 63249778
Fractured coccyx 10.23 10.00 16 238830 1043 63249133
Cough 10.22 10.00 955 237891 291788 62958388
Colitis 10.22 10.00 125 238721 48403 63201773
Haemorrhage intracranial 10.21 10.00 22 238824 13397 63236779
Cardiac murmur 10.15 10.00 25 238821 14527 63235649
Burning mouth syndrome 10.11 10.00 11 238835 500 63249676
Dysgraphia 10.09 10.00 31 238815 3215 63246961
Haemolytic anaemia 10.08 10.00 14 238832 10111 63240065
Tongue movement disturbance 10.05 10.00 9 238837 322 63249854
Sickle cell anaemia with crisis 10.05 10.00 5 238841 5998 63244178
Anuria 10.04 10.00 20 238826 12531 63237645

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 1270.43 11.19 691 75471 19143 34861626
Dysphoria 1218.65 11.19 368 75794 1934 34878835
Affect lability 1145.29 11.19 393 75769 3290 34877479
Suicidal ideation 772.19 11.19 666 75496 39722 34841047
Irritability 649.80 11.19 491 75671 24199 34856570
Sensory disturbance 553.58 11.19 270 75892 5907 34874862
Agitation 470.59 11.19 602 75560 56797 34823972
Vertigo 467.37 11.19 411 75751 25125 34855644
Paraesthesia 452.27 11.19 625 75537 63547 34817222
Insomnia 435.92 11.19 798 75364 103109 34777660
Hyperhidrosis 427.42 11.19 664 75498 75028 34805741
Nightmare 407.10 11.19 299 75863 14092 34866677
Anxiety 367.91 11.19 724 75438 98704 34782065
Serotonin syndrome 278.19 11.19 276 75886 19657 34861112
Completed suicide 267.78 11.19 632 75530 97536 34783233
Dizziness 242.19 11.19 1029 75133 217492 34663277
Hypomania 241.43 11.19 113 76049 2246 34878523
Tremor 233.13 11.19 539 75623 82048 34798721
Confusional state 226.08 11.19 759 75403 143401 34737368
Mood swings 216.29 11.19 161 76001 7740 34873029
Lethargy 215.60 11.19 349 75813 40773 34839996
Tinnitus 213.86 11.19 241 75921 19877 34860892
Headache 174.86 11.19 881 75281 199754 34681015
Nausea 161.25 11.19 1277 74885 338631 34542138
Febrile neutropenia 147.23 11.19 57 76105 136792 34743977
Suicide attempt 145.75 11.19 286 75876 38830 34841939
Pyrexia 130.35 11.19 338 75824 332675 34548094
Sleep disorder 120.85 11.19 234 75928 31454 34849315
Fatigue 115.83 11.19 1274 74888 369379 34511390
Anger 107.35 11.19 131 76031 11753 34869016
Thrombocytopenia 106.50 11.19 110 76052 156137 34724632
Acute kidney injury 105.67 11.19 328 75834 304660 34576109
Withdrawal syndrome 102.44 11.19 131 76031 12324 34868445
Depression 94.85 11.19 441 75721 96657 34784112
Sedation 92.46 11.19 165 75997 20841 34859928
Anaemia 91.76 11.19 236 75926 233099 34647670
Gastrointestinal tube insertion 87.15 11.19 46 76116 1193 34879576
Somnolence 77.04 11.19 459 75703 110657 34770112
Pancytopenia 74.32 11.19 59 76103 95098 34785671
Disturbance in attention 72.70 11.19 169 75993 25776 34854993
Feeling abnormal 69.07 11.19 297 75865 62938 34817831
Fall 68.96 11.19 710 75452 202175 34678594
Multiple organ dysfunction syndrome 68.39 11.19 41 76121 76525 34804244
Intentional self-injury 68.23 11.19 114 76048 13657 34867112
Sepsis 64.23 11.19 170 75992 166391 34714378
Memory impairment 60.67 11.19 220 75942 43098 34837671
Neutropenia 59.69 11.19 161 76001 156617 34724152
Dyspnoea 58.26 11.19 533 75629 376249 34504520
Disease progression 55.28 11.19 94 76068 107983 34772786
Intentional overdose 53.08 11.19 212 75950 43462 34837307
Antidepressant drug level above therapeutic 52.93 11.19 20 76142 226 34880543
Haemoglobin decreased 52.26 11.19 116 76046 120656 34760113
Affective disorder 51.10 11.19 55 76107 4305 34876464
Pleural effusion 50.48 11.19 62 76100 81484 34799285
Hallucination, auditory 50.38 11.19 92 76070 11825 34868944
Toxicity to various agents 50.11 11.19 661 75501 199701 34681068
Analgesic drug level above therapeutic 48.26 11.19 20 76142 293 34880476
Sexual dysfunction 48.25 11.19 64 76098 6239 34874530
Hepatic enzyme increased 47.72 11.19 190 75972 38890 34841879
Malignant neoplasm progression 47.43 11.19 74 76088 87972 34792797
Ascites 47.43 11.19 21 76141 46550 34834219
Loss of consciousness 47.08 11.19 325 75837 82342 34798427
Blood creatinine increased 46.40 11.19 85 76077 94891 34785878
Reversible airways obstruction 45.68 11.19 22 76140 467 34880302
Overdose 44.98 11.19 346 75816 90713 34790056
Urinary retention 44.77 11.19 177 75985 36111 34844658
Myoclonus 42.43 11.19 97 76065 14628 34866141
Respiratory disorder neonatal 41.91 11.19 32 76130 1598 34879171
Product used for unknown indication 41.05 11.19 26 76136 957 34879812
Renal failure 40.54 11.19 147 76015 130410 34750359
Pneumonia 40.51 11.19 552 75610 362075 34518694
Delusion of grandeur 39.49 11.19 27 76135 1133 34879636
General physical health deterioration 39.44 11.19 145 76017 128124 34752645
Haemorrhage 37.45 11.19 34 76128 51336 34829433
Respiratory failure 37.28 11.19 117 76045 108455 34772314
C-reactive protein increased 36.89 11.19 38 76124 54060 34826709
Road traffic accident 36.71 11.19 102 76060 17348 34863421
Balance disorder 36.27 11.19 180 75982 40474 34840295
Gastric bypass 35.97 11.19 16 76146 281 34880488
Psychotic disorder 35.77 11.19 126 76036 24326 34856443
Cardiac failure 35.22 11.19 93 76069 91155 34789614
Platelet count decreased 34.44 11.19 139 76023 119578 34761191
Aggression 34.39 11.19 172 75990 38792 34841977
Migraine 33.69 11.19 99 76063 17379 34863390
Cytomegalovirus infection 33.26 11.19 8 76154 26127 34854642
Growth hormone deficiency 32.94 11.19 15 76147 279 34880490
Metabolic acidosis 32.94 11.19 28 76134 43652 34837117
Feeling jittery 32.75 11.19 42 76120 3961 34876808
Bradyphrenia 32.62 11.19 46 76116 4752 34876017
Rhinalgia 32.31 11.19 23 76139 1030 34879739
Self esteem decreased 32.31 11.19 18 76144 521 34880248
Product use in unapproved indication 31.59 11.19 140 76022 117359 34763410
Abnormal dreams 31.40 11.19 58 76104 7520 34873249
Renal impairment 30.95 11.19 104 76058 94409 34786360
Urinary hesitation 30.50 11.19 34 76128 2768 34878001
Therapy interrupted 29.74 11.19 81 76081 13616 34867153
Drug resistance 29.19 11.19 10 76152 25917 34854852
Disorientation 28.93 11.19 146 76016 33042 34847727
Mania 28.91 11.19 64 76098 9447 34871322
Hypokalaemia 28.51 11.19 52 76110 58162 34822607
Pain 28.17 11.19 613 75549 204062 34676707
Surgery 28.07 11.19 81 76081 14076 34866693
Hallucination 27.86 11.19 200 75962 51298 34829471
Neuropathy peripheral 27.53 11.19 290 75872 82973 34797796
Agranulocytosis 27.14 11.19 9 76153 23812 34856957
Disseminated intravascular coagulation 27.13 11.19 7 76155 21809 34858960
Yawning 26.88 11.19 16 76146 526 34880243
Gait disturbance 26.51 11.19 293 75869 84847 34795922
Off label use 26.26 11.19 705 75457 418819 34461950
Bone marrow failure 25.64 11.19 16 76146 29237 34851532
White blood cell count decreased 25.48 11.19 114 76048 95331 34785438
Cytokine release syndrome 25.45 11.19 9 76153 22868 34857901
Post concussion syndrome 25.14 11.19 10 76152 131 34880638
Dehydration 25.00 11.19 173 75989 129796 34750973
Septic shock 24.93 11.19 77 76085 71757 34809012
Electric shock sensation 24.87 11.19 10 76152 135 34880634
Nephrolithiasis 24.75 11.19 131 76031 30202 34850567
Fibromyalgia 24.54 11.19 32 76130 3068 34877701
Initial insomnia 24.34 11.19 32 76130 3092 34877677
Major depression 24.20 11.19 39 76123 4533 34876236
Seizure 23.33 11.19 339 75823 104518 34776251
Amnesia 23.25 11.19 117 76045 26446 34854323
Hypocalcaemia 23.12 11.19 12 76150 24277 34856492
Depressed mood 22.84 11.19 93 76069 19224 34861545
Abnormal behaviour 22.58 11.19 111 76051 24858 34855911
Atrial fibrillation 22.52 11.19 165 75997 122228 34758541
Haematochezia 22.40 11.19 42 76120 46492 34834277
Cough 22.39 11.19 214 75948 149926 34730843
Drug hypersensitivity 22.33 11.19 271 75891 80258 34800511
Hepatitis E antibody positive 21.92 11.19 11 76151 256 34880513
Convulsive threshold lowered 21.90 11.19 14 76148 524 34880245
Homicidal ideation 21.72 11.19 28 76134 2654 34878115
Hypertensive emergency 21.57 11.19 18 76144 1022 34879747
Pneumocystis jirovecii pneumonia 21.51 11.19 8 76154 19702 34861067
Dystonia 21.45 11.19 62 76100 10783 34869986
Oedema peripheral 21.34 11.19 163 75999 119649 34761120
Haemoptysis 21.25 11.19 27 76135 34979 34845790
Interstitial lung disease 21.25 11.19 72 76090 65210 34815559
Complex regional pain syndrome 21.22 11.19 14 76148 553 34880216
International normalised ratio increased 20.82 11.19 45 76117 47282 34833487
Agitation neonatal 20.75 11.19 18 76144 1078 34879691
Hepatitis E virus test positive 20.74 11.19 11 76151 288 34880481
Thinking abnormal 20.61 11.19 43 76119 6094 34874675
Rash maculo-papular 20.53 11.19 19 76143 28432 34852337
Rash 20.38 11.19 352 75810 222400 34658369
Multiple sclerosis relapse 20.36 11.19 69 76093 13064 34867705
Erectile dysfunction 20.30 11.19 94 76068 20543 34860226
Erythema 20.27 11.19 112 76050 88668 34792101
Somnambulism 20.22 11.19 29 76133 3043 34877726
Toxic epidermal necrolysis 20.16 11.19 11 76151 21635 34859134
Respiratory distress 20.14 11.19 29 76133 35636 34845133
Neutropenic sepsis 20.09 11.19 3 76159 13764 34867005
Myocardial infarction 20.06 11.19 168 75994 120917 34759852
Delirium 19.97 11.19 164 75998 43827 34836942
Hypersomnia 19.96 11.19 66 76096 12341 34868428
Gastrointestinal adenocarcinoma 19.84 11.19 7 76155 64 34880705
Undifferentiated connective tissue disease 19.78 11.19 6 76156 32 34880737
Prostate cancer 19.78 11.19 35 76127 39614 34841155
Neutrophil count decreased 19.77 11.19 52 76110 51052 34829717
Acute stress disorder 19.74 11.19 9 76153 168 34880601
Neuralgia 19.68 11.19 75 76087 15038 34865731
Pneumonitis 19.67 11.19 27 76135 33851 34846918
Pericardial effusion 19.60 11.19 15 76147 24647 34856122
Blood lactate dehydrogenase increased 19.56 11.19 13 76149 22977 34857792
Drug reaction with eosinophilia and systemic symptoms 19.48 11.19 26 76136 32986 34847783
Muscle spasticity 19.47 11.19 41 76121 5847 34874922
Mental disorder 19.41 11.19 75 76087 15134 34865635
Liver function test abnormal 19.37 11.19 125 76037 30949 34849820
Drug interaction 19.33 11.19 636 75526 225310 34655459
Lymphopenia 18.91 11.19 6 76156 16329 34864440
Restless legs syndrome 18.74 11.19 50 76112 8304 34872465
Angioedema 18.64 11.19 33 76129 37341 34843428
Wrong drug 18.61 11.19 7 76155 78 34880691
Pulmonary embolism 18.49 11.19 117 76045 89629 34791140
Tumour lysis syndrome 18.49 11.19 7 76155 17052 34863717
Productive cough 18.31 11.19 34 76128 37779 34842990
Dysmetropsia 18.29 11.19 4 76158 3 34880766
Clonus 18.16 11.19 26 76136 2724 34878045
Sleep-related eating disorder 18.15 11.19 10 76152 283 34880486
Intentional product use issue 18.11 11.19 68 76094 59748 34821021
Inappropriate antidiuretic hormone secretion 18.04 11.19 65 76097 12688 34868081
Lacunar stroke 17.99 11.19 9 76153 208 34880561
Bezoar 17.97 11.19 17 76145 1140 34879629
Drug screen false positive 17.89 11.19 14 76148 725 34880044
Haematuria 17.85 11.19 53 76109 50013 34830756
Dissociation 17.84 11.19 20 76142 1638 34879131
Nephropathy toxic 17.79 11.19 3 76159 12585 34868184
Sleep sex 17.76 11.19 4 76158 4 34880765
Tubulointerstitial nephritis 17.74 11.19 12 76150 21012 34859757
Bipolar disorder 17.67 11.19 30 76132 3639 34877130
Compulsive shopping 17.66 11.19 11 76151 393 34880376
Lymphocyte count abnormal 17.47 11.19 17 76145 1181 34879588
Restlessness 17.45 11.19 105 76057 25377 34855392
Acute myeloid leukaemia 17.43 11.19 9 76153 18261 34862508
Feeling guilty 17.24 11.19 10 76152 313 34880456
Steatohepatitis 16.99 11.19 10 76152 322 34880447
Infusion related reaction 16.94 11.19 59 76103 52998 34827771
Gastrointestinal haemorrhage 16.89 11.19 118 76044 88359 34792410
Neonatal tachypnoea 16.82 11.19 8 76154 165 34880604
Mucosal inflammation 16.76 11.19 37 76125 38585 34842184
Cardiogenic shock 16.71 11.19 20 76142 26598 34854171
Stomatitis 16.65 11.19 43 76119 42471 34838298
Coronary artery disease 16.60 11.19 52 76110 48253 34832516
Forced expiratory flow decreased 16.56 11.19 8 76154 171 34880598
Tardive dyskinesia 16.52 11.19 38 76124 5752 34875017
Paedophilia 16.49 11.19 4 76158 7 34880762
Psychomotor hyperactivity 16.21 11.19 52 76110 9570 34871199
Multiple sclerosis 16.16 11.19 41 76121 6604 34874165
Dissociative disorder 16.16 11.19 11 76151 458 34880311
Cholestasis 16.13 11.19 21 76141 26927 34853842
Rhabdomyolysis 16.11 11.19 85 76077 68078 34812691
Apathy 16.06 11.19 42 76120 6890 34873879
Hallucination, visual 16.02 11.19 79 76083 17712 34863057
Cardiac failure congestive 15.92 11.19 111 76051 83159 34797610
Panic attack 15.91 11.19 51 76111 9381 34871388
Loss of control of legs 15.86 11.19 13 76149 720 34880049
Paranoia 15.80 11.19 60 76102 12008 34868761
Ventricular fibrillation 15.78 11.19 16 76146 22938 34857831
Schizophrenia 15.67 11.19 48 76114 8618 34872151
Intentional product misuse 15.60 11.19 160 76002 45451 34835318
Adenocarcinoma of appendix 15.58 11.19 7 76155 126 34880643
Delirium tremens 15.39 11.19 12 76150 618 34880151
Hyperlipasaemia 15.39 11.19 11 76151 496 34880273
Alcoholism 15.29 11.19 25 76137 2940 34877829
Orgasm abnormal 15.29 11.19 7 76155 132 34880637
Abdominal pain 15.13 11.19 258 75904 163360 34717409
Chest injury 15.12 11.19 18 76144 1573 34879196
Ventricular hypoplasia 15.05 11.19 6 76156 79 34880690
Palmar-plantar erythrodysaesthesia syndrome 14.97 11.19 9 76153 16786 34863983
Drug screen positive 14.88 11.19 29 76133 3914 34876855
Neonatal hyponatraemia 14.85 11.19 6 76156 82 34880687
Cerebral infarction 14.84 11.19 23 76139 27432 34853337
Urethral discharge 14.77 11.19 4 76158 13 34880756
Narcissistic personality disorder 14.77 11.19 4 76158 13 34880756
Libido decreased 14.72 11.19 32 76130 4664 34876105
Hypoxia 14.58 11.19 66 76096 55029 34825740
Dyskinesia 14.49 11.19 91 76071 22322 34858447
Ileus 14.49 11.19 9 76153 16490 34864279
Acute myocardial infarction 14.43 11.19 64 76098 53655 34827114
Snoring 14.35 11.19 26 76136 3320 34877449
Therapy cessation 14.32 11.19 74 76088 16899 34863870
Speech sound disorder 14.31 11.19 7 76155 154 34880615
Treatment failure 14.19 11.19 53 76109 46644 34834125
Influenza like illness 14.18 11.19 106 76056 27528 34853241
Norepinephrine increased 14.12 11.19 4 76158 16 34880753
Blood urea increased 14.09 11.19 28 76134 30336 34850433
Stiff person syndrome 14.00 11.19 6 76156 96 34880673
Lymphoma 13.78 11.19 5 76157 12502 34868267
Extrapyramidal disorder 13.66 11.19 60 76102 12820 34867949
Tethered cord syndrome 13.57 11.19 4 76158 19 34880750
Epistaxis 13.56 11.19 73 76089 58178 34822591
Deep vein thrombosis 13.47 11.19 85 76077 65163 34815606
Hypotension 13.41 11.19 374 75788 221275 34659494
Renal aplasia 13.34 11.19 12 76150 754 34880015
Psychopathic personality 13.32 11.19 3 76159 3 34880766
Ureteric haemorrhage 13.26 11.19 6 76156 110 34880659
Axillary pain 13.24 11.19 9 76153 374 34880395
Prescribed overdose 13.18 11.19 52 76110 10595 34870174
Respiratory depression 13.14 11.19 70 76092 16175 34864594
Orthostatic hypotension 13.06 11.19 99 76063 25820 34854949
Loss of employment 13.00 11.19 10 76152 505 34880264
Homicide 12.97 11.19 13 76149 936 34879833
Colitis 12.72 11.19 41 76121 37709 34843060
Suicidal behaviour 12.71 11.19 16 76146 1481 34879288
Death 12.68 11.19 724 75438 397325 34483444
Cyanosis 12.61 11.19 6 76156 12758 34868011
Lymphadenopathy 12.57 11.19 27 76135 28436 34852333
Aplastic anaemia 12.31 11.19 3 76159 9713 34871056
Chills 12.29 11.19 115 76047 80928 34799841
Retrograde ejaculation 12.24 11.19 9 76153 424 34880345
Pre-existing condition improved 12.23 11.19 21 76141 2571 34878198
Melaena 12.22 11.19 38 76124 35342 34845427
Lung disorder 12.17 11.19 37 76125 34659 34846110
Helplessness 12.14 11.19 5 76157 72 34880697
Infection 12.13 11.19 133 76029 90782 34789987
Hypomagnesaemia 12.11 11.19 18 76144 21833 34858936
Slow speech 12.09 11.19 14 76148 1188 34879581
Graft versus host disease 12.03 11.19 4 76158 10565 34870204
Selective eating disorder 12.02 11.19 17 76145 1761 34879008
Mitral valve incompetence 11.99 11.19 9 76153 14934 34865835
Facial spasm 11.99 11.19 7 76155 222 34880547
Brief psychotic disorder with marked stressors 11.93 11.19 7 76155 224 34880545
Acute hepatic failure 11.92 11.19 8 76154 14066 34866703
Leukopenia 11.91 11.19 84 76078 62772 34817997
Autonomic dysreflexia 11.90 11.19 5 76157 76 34880693
Hyperglycaemia 11.87 11.19 45 76117 39435 34841334
Device related infection 11.87 11.19 12 76150 17225 34863544
Drug tolerance 11.87 11.19 22 76140 2860 34877909
Product administration interrupted 11.75 11.19 17 76145 1798 34878971
Depersonalisation/derealisation disorder 11.74 11.19 10 76152 584 34880185
Morbid thoughts 11.74 11.19 7 76155 231 34880538
Peritonitis 11.72 11.19 11 76151 16354 34864415
Abulia 11.65 11.19 10 76152 590 34880179
Reflexes abnormal 11.65 11.19 8 76154 338 34880431
Dementia 11.64 11.19 60 76102 13688 34867081
Blue toe syndrome 11.64 11.19 6 76156 148 34880621
Panic disorder 11.61 11.19 14 76148 1240 34879529
Hyperreflexia 11.40 11.19 23 76139 3183 34877586
Lung infiltration 11.39 11.19 7 76155 12898 34867871
Pulmonary fibrosis 11.36 11.19 14 76148 18382 34862387
Mood altered 11.31 11.19 44 76118 8908 34871861
Hepatic cytolysis 11.29 11.19 9 76153 14487 34866282
Hyperbilirubinaemia 11.29 11.19 12 76150 16831 34863938

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug withdrawal syndrome 980.01 9.93 798 222573 33920 79487097
Suicidal ideation 861.96 9.93 1066 222305 75274 79445743
Serotonin syndrome 838.52 9.93 818 222553 44209 79476808
Completed suicide 569.92 9.93 1746 221625 244021 79276996
Hyperhidrosis 489.93 9.93 1216 222155 150276 79370741
Dysphoria 474.18 9.93 242 223129 4492 79516525
Affect lability 402.98 9.93 298 223073 10961 79510056
Irritability 361.16 9.93 508 222863 40636 79480381
Tremor 352.41 9.93 1163 222208 168920 79352097
Anxiety 346.06 9.93 1496 221875 247016 79274001
Nightmare 345.95 9.93 394 222977 25467 79495550
Febrile neutropenia 325.48 9.93 120 223251 230879 79290138
Agitation 301.94 9.93 781 222590 98934 79422083
Suicide attempt 269.25 9.93 667 222704 82265 79438752
Depression 262.08 9.93 1252 222119 215538 79305479
Stubbornness 259.32 9.93 79 223292 316 79520701
Pemphigus 258.13 9.93 4 223367 99578 79421439
Feeling abnormal 256.65 9.93 1003 222368 158196 79362821
Insomnia 256.34 9.93 1359 222012 243811 79277206
Somnolence 242.55 9.93 1314 222057 237667 79283350
Thrombocytopenia 238.08 9.93 235 223136 265024 79255993
Withdrawal syndrome 237.78 9.93 333 223038 26521 79494496
Dizziness 216.35 9.93 2339 221032 524102 78996915
Pyrexia 215.93 9.93 1073 222298 677636 78843381
Mood swings 210.46 9.93 269 223102 19611 79501406
Sensory disturbance 200.45 9.93 229 223142 14848 79506169
Fall 200.02 9.93 2166 221205 485463 79035554
Neutropenia 198.37 9.93 312 223059 287398 79233619
Vertigo 195.76 9.93 528 222843 68554 79452463
Anaemia 191.61 9.93 624 222747 444391 79076626
Pericarditis 187.18 9.93 33 223338 104203 79416814
Pancytopenia 178.15 9.93 123 223248 165622 79355395
Glossodynia 176.49 9.93 37 223334 103300 79417717
Hand deformity 175.86 9.93 38 223333 103881 79417136
Acute kidney injury 173.22 9.93 807 222564 518597 79002420
Paraesthesia 172.41 9.93 960 222411 175363 79345654
Headache 171.54 9.93 2675 220696 651097 78869920
Mood altered 169.57 9.93 229 223142 17618 79503399
Duodenal ulcer perforation 162.47 9.93 5 223366 66206 79454811
Thinking abnormal 150.34 9.93 185 223186 12976 79508041
Nausea 149.35 9.93 3618 219753 953578 78567439
Synovitis 147.72 9.93 123 223248 150611 79370406
Affective disorder 145.25 9.93 146 223225 8173 79512844
Disturbance in attention 142.63 9.93 387 222984 50414 79470603
Intentional self-injury 141.13 9.93 293 223078 32126 79488891
Crying 141.12 9.93 241 223130 22802 79498215
Contraindicated product administered 139.61 9.93 141 223230 157397 79363620
Confusional state 135.96 9.93 1425 221946 316572 79204445
Anger 134.68 9.93 201 223170 16961 79504056
Migraine 133.46 9.93 542 222829 86951 79434066
Inappropriate antidiuretic hormone secretion 127.90 9.93 249 223122 26064 79494953
Loss of consciousness 120.07 9.93 844 222527 167099 79353918
Memory impairment 119.77 9.93 624 222747 111110 79409907
Depressed mood 118.22 9.93 351 223020 48129 79472888
Drug interaction 116.00 9.93 1718 221653 413465 79107552
General physical health deterioration 113.47 9.93 393 222978 274845 79246172
Electric shock 113.34 9.93 62 223309 1332 79519685
Folliculitis 112.46 9.93 12 223359 55368 79465649
Toxicity to various agents 111.46 9.93 1728 221643 419812 79101205
C-reactive protein abnormal 110.82 9.93 6 223365 48361 79472656
Malignant neoplasm progression 108.11 9.93 133 223238 135857 79385160
Abnormal behaviour 107.84 9.93 283 223088 36138 79484879
Anti-cyclic citrullinated peptide antibody positive 107.59 9.93 49 223322 83094 79437923
Disease progression 107.19 9.93 222 223149 184140 79336877
Tinnitus 107.17 9.93 320 223051 44013 79477004
Multiple sclerosis relapse 106.98 9.93 330 223041 46203 79474814
Sepsis 106.87 9.93 391 222980 269037 79251980
Product substitution issue 105.00 9.93 197 223174 20059 79500958
Coordination abnormal 104.61 9.93 180 223191 17132 79503885
Platelet count decreased 104.47 9.93 245 223126 194419 79326598
Somatic symptom disorder 104.17 9.93 73 223298 2464 79518553
Multiple sclerosis 103.64 9.93 207 223164 22075 79498942
Systemic lupus erythematosus 103.31 9.93 112 223259 121037 79399980
Cardiac failure 101.87 9.93 173 223198 154669 79366348
Wound 98.41 9.93 108 223263 116071 79404946
Sleep disorder due to general medical condition, insomnia type 97.96 9.93 6 223365 43550 79477467
Multiple organ dysfunction syndrome 95.16 9.93 118 223253 120128 79400889
Myelosuppression 92.32 9.93 5 223366 40291 79480726
Tardive dyskinesia 91.96 9.93 130 223241 10441 79510576
Fibromyalgia 91.38 9.93 390 222981 63950 79457067
Off label use 91.12 9.93 1895 221476 905320 78615697
Post-traumatic stress disorder 89.54 9.93 88 223283 4793 79516224
Infusion related reaction 88.11 9.93 339 223032 229898 79291119
Muscle injury 87.99 9.93 15 223356 48546 79472471
Treatment failure 87.19 9.93 220 223151 170266 79350751
Ascites 86.72 9.93 52 223319 75510 79445507
Septic shock 85.65 9.93 132 223239 122669 79398348
Panic attack 85.21 9.93 201 223170 24015 79497002
Renal failure 84.80 9.93 284 223087 200684 79320333
Reversible cerebral vasoconstriction syndrome 83.55 9.93 69 223302 2988 79518029
Restless legs syndrome 82.12 9.93 177 223194 19915 79501102
Hypomania 81.30 9.93 103 223268 7441 79513576
Pain 81.28 9.93 2561 220810 701241 78819776
Alopecia 80.80 9.93 353 223018 231002 79290015
Intentional overdose 80.73 9.93 541 222830 105419 79415598
Urinary retention 80.22 9.93 343 223028 56287 79464730
Coma 79.17 9.93 518 222853 100131 79420886
Blood creatinine increased 78.58 9.93 201 223170 154856 79366161
Renal impairment 78.08 9.93 207 223164 157576 79363441
Surgery 77.77 9.93 235 223136 32531 79488486
Personality disorder 77.75 9.93 91 223280 6055 79514962
Therapy interrupted 76.49 9.93 227 223144 31114 79489903
Discomfort 74.06 9.93 150 223221 125467 79395550
Blister 73.62 9.93 139 223232 119337 79401680
Hallucination 73.45 9.93 451 222920 85294 79435723
Mental disorder 72.89 9.93 223 223148 31079 79489938
Hyperreflexia 72.76 9.93 103 223268 8282 79512735
Drug intolerance 72.43 9.93 438 222933 263681 79257336
Pleural effusion 72.31 9.93 190 223181 145072 79375945
Fatigue 71.99 9.93 3236 220135 926491 78594526
Cytomegalovirus infection 71.31 9.93 16 223355 42628 79478389
Rash 70.71 9.93 1167 222204 577191 78943826
Helicobacter infection 70.61 9.93 55 223316 69649 79451368
Balance disorder 69.55 9.93 495 222876 98362 79422655
Hypersensitivity 68.74 9.93 441 222930 261798 79259219
Lymphocytic oesophagitis 68.49 9.93 17 223354 23 79520994
Nasal turbinate hypertrophy 67.13 9.93 35 223336 680 79520337
Pneumonia aspiration 66.97 9.93 367 223004 66600 79454417
Opsoclonus myoclonus 66.90 9.93 25 223346 207 79520810
Therapy cessation 66.50 9.93 244 223127 37318 79483699
Hallucination, visual 66.05 9.93 222 223149 32507 79488510
Mania 65.82 9.93 153 223218 18107 79502910
Arthropathy 65.05 9.93 265 223106 176846 79344171
Sopor 64.94 9.93 222 223149 32788 79488229
Oesophageal spasm 64.69 9.93 63 223308 3393 79517624
Neutrophil count decreased 64.56 9.93 102 223269 93857 79427160
Rheumatic fever 63.94 9.93 4 223367 28521 79492496
Product dose omission issue 63.88 9.93 1011 222360 246526 79274491
Colitis microscopic 63.80 9.93 111 223260 10657 79510360
Drug reaction with eosinophilia and systemic symptoms 63.43 9.93 52 223319 64192 79456825
Neutropenic sepsis 63.13 9.93 3 223368 27061 79493956
Stomatitis 62.85 9.93 206 223165 146551 79374466
Psoriasis 62.68 9.93 448 222923 89139 79431878
Rheumatoid factor positive 62.17 9.93 46 223325 59793 79461224
Hypocalcaemia 62.17 9.93 31 223340 49893 79471124
Haemoglobin decreased 61.60 9.93 367 223004 221752 79299265
Influenza like illness 61.31 9.93 377 222994 71330 79449687
Swelling 60.66 9.93 357 223014 216354 79304663
Vision blurred 60.42 9.93 505 222866 105393 79415624
Blood pressure increased 60.22 9.93 878 222493 210482 79310535
Bronchial neoplasm 59.85 9.93 29 223342 479 79520538
Rubber sensitivity 59.70 9.93 45 223326 1704 79519313
Joint swelling 59.64 9.93 519 222852 288127 79232890
Gastric bypass 59.48 9.93 40 223331 1261 79519756
Abnormal dreams 59.16 9.93 111 223260 11301 79509716
Bone marrow failure 58.88 9.93 35 223336 51072 79469945
Coma blister 58.83 9.93 23 223348 218 79520799
Intervertebral discitis 58.62 9.93 70 223301 4758 79516259
Lower respiratory tract infection 58.41 9.93 177 223194 129043 79391974
Neck deformity 57.73 9.93 45 223326 1792 79519225
Maternal exposure during pregnancy 56.86 9.93 194 223177 136344 79384673
Atrial fibrillation 55.91 9.93 325 223046 197561 79323456
Gastrointestinal tube insertion 55.77 9.93 42 223329 1588 79519429
Drug hypersensitivity 55.69 9.93 1160 222211 297756 79223261
Oedema peripheral 55.56 9.93 446 222925 251842 79269175
Amnesia 55.47 9.93 334 223037 62723 79458294
Erythema 55.24 9.93 382 222989 222908 79298109
Hot flush 55.04 9.93 301 223070 54576 79466441
Disorientation 54.90 9.93 332 223039 62444 79458573
Mucosal inflammation 54.87 9.93 79 223292 75501 79445516
Pneumonia 54.65 9.93 1420 221951 658826 78862191
Lethargy 54.27 9.93 402 222969 80890 79440127
Pulmonary malformation 52.55 9.93 21 223350 212 79520805
Temperature intolerance 52.32 9.93 96 223275 9609 79511408
Impaired healing 52.24 9.93 104 223267 87551 79433466
Dyskinesia 52.12 9.93 256 223115 44517 79476500
Endometrial ablation 52.07 9.93 32 223339 861 79520156
Hallucination, auditory 51.56 9.93 151 223220 20542 79500475
Extremity contracture 51.36 9.93 41 223330 1691 79519326
Overdose 51.21 9.93 762 222609 183444 79337573
Sedation 50.94 9.93 283 223088 51612 79469405
Bradyphrenia 50.87 9.93 100 223271 10540 79510477
Bronchopulmonary aspergillosis 50.35 9.93 3 223368 22291 79498726
Pulmonary fibrosis 49.72 9.93 31 223340 44081 79476936
Weight increased 49.57 9.93 1070 222301 276316 79244701
Stiff person syndrome 49.18 9.93 22 223349 300 79520717
Interstitial lung disease 48.94 9.93 157 223214 112443 79408574
Neurologic neglect syndrome 48.89 9.93 50 223321 2857 79518160
Dyspnoea 48.88 9.93 1935 221436 855090 78665927
Carotid artery thrombosis 48.63 9.93 51 223320 3002 79518015
White blood cell count decreased 48.62 9.93 318 223053 187970 79333047
Respiratory failure 48.53 9.93 302 223069 180609 79340408
Infection 48.42 9.93 438 222933 241274 79279743
Libido increased 48.20 9.93 42 223329 1959 79519058
Clonus 47.89 9.93 76 223295 6764 79514253
Hyperaesthesia 46.92 9.93 105 223266 12117 79508900
Dissociation 46.69 9.93 57 223314 3964 79517053
Sleep apnoea syndrome 46.41 9.93 214 223157 36264 79484753
Leukopenia 46.20 9.93 169 223202 116344 79404673
Abdominal discomfort 46.11 9.93 464 222907 250263 79270754
Lung cyst 45.45 9.93 21 223350 310 79520707
Intentional product misuse 44.17 9.93 434 222937 94731 79426286
Red blood cell sedimentation rate abnormal 43.98 9.93 4 223367 20959 79500058
Self esteem decreased 43.88 9.93 30 223341 972 79520045
Cytokine release syndrome 43.85 9.93 23 223348 35975 79485042
Rash maculo-papular 43.34 9.93 56 223315 56022 79464995
Restlessness 43.30 9.93 250 223121 46242 79474775
Morbid thoughts 42.38 9.93 27 223344 775 79520242
Irritable bowel syndrome 42.35 9.93 68 223303 62173 79458844
Pneumocystis jirovecii pneumonia 42.30 9.93 19 223352 32489 79488528
Hyperkalaemia 42.10 9.93 171 223200 114227 79406790
Gastrointestinal haemorrhage 41.50 9.93 243 223128 147476 79373541
Sleep disorder 41.37 9.93 394 222977 85283 79435734
Dry mouth 41.14 9.93 402 222969 87617 79433400
Drug resistance 40.65 9.93 35 223336 42178 79478839
Skin haemorrhage 40.59 9.93 98 223273 11883 79509134
Coronary artery disease 40.47 9.93 76 223295 65398 79455619
Hypomagnesaemia 40.39 9.93 43 223328 46868 79474149
Agranulocytosis 40.21 9.93 40 223331 44990 79476027
Therapeutic product effect decreased 40.18 9.93 281 223090 163582 79357435
Major depression 40.06 9.93 82 223289 8898 79512119
Myoclonus 39.52 9.93 168 223203 27492 79493525
Psychotic disorder 39.46 9.93 224 223147 41178 79479839
Autonomic dysreflexia 39.42 9.93 21 223350 427 79520590
Paranoia 39.38 9.93 132 223239 19300 79501717
Rapid eye movements sleep abnormal 39.25 9.93 18 223353 261 79520756
Akathisia 39.21 9.93 103 223268 13156 79507861
Cystitis 38.81 9.93 267 223104 52465 79468552
Acute myeloid leukaemia 38.72 9.93 19 223352 30866 79490151
Cardiac failure congestive 38.56 9.93 237 223134 142165 79378852
Bone density abnormal 38.20 9.93 45 223326 3015 79518002
Analgesic drug level above therapeutic 37.70 9.93 21 223350 468 79520549
Hypersomnia 37.58 9.93 146 223225 22940 79498077
Rebound nasal congestion 37.55 9.93 10 223361 21 79520996
Hostility 37.53 9.93 39 223332 2271 79518746
Head injury 37.49 9.93 205 223166 37164 79483853
Muscle twitching 37.41 9.93 153 223218 24611 79496406
Muscle spasms 37.19 9.93 692 222679 174038 79346979
Anovulatory cycle 36.84 9.93 14 223357 122 79520895
Disseminated intravascular coagulation 36.65 9.93 28 223343 35814 79485203
Neck mass 36.60 9.93 53 223318 4351 79516666
Tubulointerstitial nephritis 36.46 9.93 32 223339 38203 79482814
Haemoptysis 36.41 9.93 63 223308 55936 79465081
Alanine aminotransferase increased 36.41 9.93 649 222722 161921 79359096
Concussion 35.77 9.93 81 223290 9422 79511595
Neuralgia 35.44 9.93 186 223185 33198 79487819
Sacroiliitis 35.40 9.93 48 223323 3706 79517311
Sensitivity to weather change 35.33 9.93 73 223298 7974 79513043
Sleep-related eating disorder 35.18 9.93 23 223348 691 79520326
Bipolar disorder 35.12 9.93 71 223300 7636 79513381
Ankle fracture 35.04 9.93 116 223255 16853 79504164
Gait disturbance 35.01 9.93 794 222577 206712 79314305
Toxic epidermal necrolysis 34.99 9.93 44 223327 44537 79476480
Product use in unapproved indication 34.64 9.93 493 222878 249866 79271151
Aspergillus infection 34.53 9.93 6 223365 19155 79501862
Bronchial haemorrhage 34.43 9.93 29 223342 1291 79519726
Delusion of grandeur 34.38 9.93 30 223341 1402 79519615
Cardiogenic shock 34.35 9.93 40 223331 41874 79479143
Decompression sickness 34.10 9.93 12 223359 82 79520935
Palmar-plantar erythrodysaesthesia syndrome 33.74 9.93 26 223345 33108 79487909
Ill-defined disorder 33.66 9.93 85 223286 65790 79455227
Post cholecystectomy syndrome 33.44 9.93 18 223353 374 79520643
Oesophageal pain 33.40 9.93 50 223321 4229 79516788
Premature delivery 33.33 9.93 12 223359 23455 79497562
Sinus disorder 33.31 9.93 138 223233 22326 79498691
Joint noise 33.28 9.93 48 223323 3926 79517091
Melaena 33.14 9.93 76 223295 60814 79460203
Libido decreased 33.04 9.93 56 223315 5265 79515752
Spinal operation 32.65 9.93 70 223301 7847 79513170
Epistaxis 32.64 9.93 181 223190 111334 79409683
Rheumatoid nodule 32.45 9.93 5 223366 17433 79503584
Psychotic disorder due to a general medical condition 32.45 9.93 16 223355 275 79520742
Hypoaesthesia 32.38 9.93 693 222678 178659 79342358
Aggression 31.76 9.93 248 223123 50710 79470307
Adjustment disorder 31.60 9.93 47 223324 3953 79517064
Respiratory tract congestion 31.51 9.93 125 223246 19829 79501188
Blood lactate dehydrogenase increased 31.44 9.93 38 223333 39132 79481885
Antidepressant drug level above therapeutic 31.42 9.93 21 223350 655 79520362
Nervousness 31.33 9.93 180 223191 33235 79487782
Cerebral infarction 30.98 9.93 50 223321 45626 79475391
Respiratory tract malformation 30.95 9.93 12 223359 111 79520906
Sinus congestion 30.91 9.93 124 223247 19772 79501245
Demyelination 30.88 9.93 69 223302 7954 79513063
C-reactive protein increased 30.78 9.93 223 223148 128804 79392213
Apathy 30.72 9.93 93 223278 12884 79508133
Phagophobia 30.71 9.93 10 223361 52 79520965
Bacteraemia 30.66 9.93 28 223343 32796 79488221
Lactic acidosis 30.64 9.93 98 223273 70261 79450756
Muscle spasticity 30.35 9.93 130 223241 21345 79499672
Prostate cancer 30.34 9.93 29 223342 33239 79487778
Intentional product use issue 30.28 9.93 276 223095 151836 79369181
Speech disorder 30.18 9.93 258 223113 54187 79466830
Formication 30.05 9.93 52 223319 4971 79516046
Haematuria 29.89 9.93 96 223275 68740 79452277
Impaired driving ability 29.74 9.93 54 223317 5361 79515656
Tumour lysis syndrome 29.60 9.93 15 223356 23924 79497093
Live birth 29.46 9.93 8 223363 18736 79502281
Psychomotor hyperactivity 29.44 9.93 109 223262 16740 79504277
Poor quality sleep 29.42 9.93 134 223237 22588 79498429
Aplastic anaemia 29.37 9.93 7 223364 17898 79503119
Product tampering 29.28 9.93 17 223354 411 79520606
Hypnopompic hallucination 29.24 9.93 11 223360 93 79520924
Metabolic surgery 29.00 9.93 25 223346 1149 79519868
Neoplasm progression 28.54 9.93 64 223307 51618 79469399
Respiratory distress 28.49 9.93 77 223294 58262 79462755
Alcoholism 28.35 9.93 43 223328 3680 79517337
Dehydration 28.22 9.93 507 222864 247680 79273337
Peripheral swelling 28.13 9.93 559 222812 269058 79251959
Enterococcal infection 28.01 9.93 5 223366 15655 79505362
Haematotoxicity 27.66 9.93 5 223366 15514 79505503
Emotional disorder 27.64 9.93 96 223275 14291 79506726
Galactorrhoea 27.60 9.93 42 223329 3604 79517413
Cholestasis 27.59 9.93 66 223305 52043 79468974
Metabolic acidosis 27.53 9.93 128 223243 82401 79438616
Lung disorder 26.84 9.93 125 223246 80432 79440585
Gastrooesophageal reflux disease 26.56 9.93 425 222946 103821 79417196
Adulterated product 26.49 9.93 14 223357 280 79520737
Blood immunoglobulin A increased 26.47 9.93 22 223349 961 79520056
Poor sucking reflex 26.45 9.93 11 223360 124 79520893
Graft versus host disease 26.44 9.93 5 223366 15021 79505996
Aspartate aminotransferase increased 26.42 9.93 540 222831 138101 79382916
Toxic skin eruption 26.06 9.93 15 223356 22278 79498739
Thrombotic microangiopathy 25.91 9.93 12 223359 20157 79500860
Lactation disorder 25.88 9.93 13 223358 233 79520784
Carcinoid tumour pulmonary 25.60 9.93 15 223356 369 79520648
Lymphocyte count abnormal 25.55 9.93 26 223345 1477 79519540
Cognitive disorder 25.53 9.93 304 223067 69622 79451395
Blood calcium decreased 25.40 9.93 31 223340 31788 79489229
Cataplexy 25.36 9.93 21 223350 913 79520104
Therapy non-responder 25.31 9.93 153 223218 92152 79428865
Pain in extremity 25.28 9.93 1256 222115 363282 79157735
Suspected suicide 25.23 9.93 76 223295 10500 79510517
Neck pain 25.00 9.93 322 223049 75095 79445922
Creatinine renal clearance decreased 24.89 9.93 11 223360 18991 79502026
Thunderclap headache 24.86 9.93 15 223356 390 79520627
Pathogen resistance 24.76 9.93 5 223366 14337 79506680
Loss of control of legs 24.70 9.93 29 223342 1936 79519081
Product use issue 24.69 9.93 426 222945 209396 79311621
Gastrointestinal disorder 24.64 9.93 221 223150 121984 79399033
Drug eruption 24.60 9.93 54 223317 43881 79477136
Bladder cancer 24.50 9.93 12 223359 19514 79501503
Skin necrosis 24.44 9.93 10 223361 18077 79502940
Eosinophilia 24.36 9.93 57 223314 45288 79475729
Pulseless electrical activity 24.31 9.93 5 223366 14155 79506862
Drug screen positive 24.30 9.93 53 223318 6010 79515007
Growth hormone deficiency 24.00 9.93 15 223356 416 79520601
Dystonia 23.94 9.93 121 223250 21278 79499739
Snoring 23.86 9.93 50 223321 5516 79515501
Tenosynovitis 23.77 9.93 7 223364 15547 79505470
Myelodysplastic syndrome 23.68 9.93 30 223341 30271 79490746
Bradycardia 23.62 9.93 254 223117 135303 79385714
Genital pain 23.57 9.93 19 223352 795 79520222
Lip dry 23.45 9.93 7 223364 15411 79505606
Dissociative disorder 23.42 9.93 19 223352 802 79520215
Ejection fraction decreased 23.31 9.93 38 223333 34539 79486478
Middle insomnia 23.27 9.93 98 223273 15971 79505046
Post-traumatic neck syndrome 23.22 9.93 29 223342 2065 79518952
Bruxism 23.20 9.93 41 223330 3985 79517032
Product used for unknown indication 23.19 9.93 25 223346 1519 79519498
Muscular weakness 23.17 9.93 602 222769 160127 79360890
Pseudomonas infection 23.13 9.93 15 223356 20888 79500129
Hypokalaemia 23.09 9.93 275 223096 143765 79377252
Epstein-Barr virus infection 22.94 9.93 6 223365 14410 79506607
Speech sound disorder 22.94 9.93 8 223363 53 79520964
Musculoskeletal discomfort 22.79 9.93 113 223258 19722 79501295
Second primary malignancy 22.79 9.93 6 223365 14344 79506673
Hypotension 22.70 9.93 1005 222366 439312 79081705
Electric shock sensation 22.67 9.93 19 223352 840 79520177
Hypoalbuminaemia 22.60 9.93 16 223355 21281 79499736
Proteinuria 22.59 9.93 35 223336 32467 79488550
Acute myocardial infarction 22.56 9.93 125 223246 76911 79444106
Delusion 22.51 9.93 115 223256 20308 79500709
Acute pulmonary oedema 22.50 9.93 6 223365 14224 79506793
Feeling guilty 22.50 9.93 19 223352 849 79520168
Eating disorder 22.44 9.93 116 223255 20581 79500436
Acute respiratory distress syndrome 22.40 9.93 57 223314 44010 79477007
Maternal exposure during breast feeding 22.40 9.93 33 223338 2752 79518265
Pneumonitis 22.37 9.93 91 223280 60769 79460248
Poisoning 22.31 9.93 134 223237 25138 79495879
Hepatotoxicity 22.03 9.93 72 223299 51280 79469737
Anorgasmia 21.88 9.93 22 223349 1232 79519785
Somnambulism 21.79 9.93 49 223322 5672 79515345
Hyperglycaemia 21.78 9.93 112 223259 70223 79450794
Deep vein thrombosis 21.70 9.93 225 223146 120694 79400323
Pre-existing condition improved 21.59 9.93 48 223323 5515 79515502
Pustular psoriasis 21.57 9.93 44 223327 4762 79516255
Feeling jittery 21.55 9.93 82 223289 12759 79508258
Metastases to bone 21.47 9.93 22 223349 24405 79496612
Hypoventilation 21.24 9.93 56 223315 7168 79513849
Depressive symptom 21.18 9.93 52 223319 6371 79514646
Device related infection 21.02 9.93 40 223331 34254 79486763
Pulmonary eosinophilia 20.83 9.93 17 223354 724 79520293
Gambling disorder 20.79 9.93 27 223344 1999 79519018
Bronchial disorder 20.75 9.93 30 223341 2459 79518558
Myocardial infarction 20.65 9.93 377 222994 183752 79337265
Inflammation 20.49 9.93 166 223205 93587 79427430
Abortion spontaneous 20.30 9.93 147 223224 29360 79491657
Hypoxia 20.25 9.93 188 223183 103055 79417962
Hypertonia 20.20 9.93 55 223316 7177 79513840
Urinary incontinence 20.18 9.93 189 223182 40720 79480297
Oedema 20.06 9.93 226 223145 119354 79401663
Palpitations 19.96 9.93 480 222891 126130 79394887
International normalised ratio increased 19.93 9.93 147 223224 84574 79436443
Aspartate aminotransferase 19.90 9.93 15 223356 568 79520449
Increased appetite 19.70 9.93 76 223295 11902 79509115
Sexual dysfunction 19.68 9.93 57 223314 7706 79513311
Dyspnoea exertional 19.57 9.93 153 223218 86920 79434097
Phobia of driving 19.52 9.93 4 223367 0 79521017
Depression suicidal 19.46 9.93 37 223334 3805 79517212
Therapeutic response changed 19.42 9.93 21 223350 1280 79519737
Tension 19.39 9.93 40 223331 4364 79516653
Rhonchi 19.38 9.93 38 223333 3998 79517019
Angioedema 19.32 9.93 129 223242 75906 79445111
Hepatitis E antibody positive 19.28 9.93 11 223360 257 79520760
Mydriasis 19.21 9.93 99 223272 17544 79503473
Metastases to liver 19.20 9.93 31 223340 28283 79492734
Cytomegalovirus viraemia 19.18 9.93 6 223365 12815 79508202
Drug abuse 19.18 9.93 594 222777 162097 79358920
Hip arthroplasty 19.16 9.93 45 223326 35711 79485306
Motor dysfunction 19.16 9.93 87 223284 14646 79506371
Ankylosing spondylitis 18.91 9.93 76 223295 12129 79508888
Progressive multiple sclerosis 18.80 9.93 20 223351 1197 79519820
Initial insomnia 18.62 9.93 52 223319 6886 79514131
Drug screen false positive 18.52 9.93 19 223352 1090 79519927
Shoulder operation 18.48 9.93 30 223341 2722 79518295
Hyperbilirubinaemia 18.42 9.93 25 223346 24493 79496524
Homicidal ideation 18.39 9.93 34 223337 3423 79517594
Exposure via breast milk 18.35 9.93 18 223353 978 79520039
Aphasia 18.32 9.93 206 223165 46526 79474491
Nephrolithiasis 18.29 9.93 229 223142 53062 79467955
Product prescribing error 18.24 9.93 199 223172 44614 79476403
Hepatitis E virus test positive 18.23 9.93 11 223360 286 79520731
Bone erosion 18.18 9.93 14 223357 17833 79503184
Respiratory depression 18.07 9.93 136 223235 27494 79493523
Pulmonary oedema 18.05 9.93 159 223212 88095 79432922
Arteriosclerosis coronary artery 18.05 9.93 98 223273 17718 79503299
Urinary tract infection 18.03 9.93 941 222430 273571 79247446
Decreased interest 17.98 9.93 35 223336 3662 79517355
Road traffic accident 17.82 9.93 194 223177 43470 79477547
Scar 17.76 9.93 87 223284 15109 79505908
Dysphagia 17.75 9.93 458 222913 121678 79399339
Basal cell carcinoma 17.75 9.93 50 223321 37325 79483692
Haemophagocytic lymphohistiocytosis 17.72 9.93 21 223350 21816 79499201
Spinal disorder 17.61 9.93 66 223305 10194 79510823
Flat affect 17.60 9.93 25 223346 2016 79519001
CYP3A4 polymorphism 17.58 9.93 7 223364 70 79520947
Haemodialysis 17.57 9.93 15 223356 18153 79502864
Feeling drunk 17.51 9.93 40 223331 4679 79516338
Vasculitis 17.48 9.93 27 223344 25075 79495942
Compulsive shopping 17.42 9.93 16 223355 800 79520217
Haemorrhage 17.41 9.93 167 223204 90951 79430066
Pneumothorax 17.39 9.93 33 223338 28290 79492727
Renal tubular necrosis 17.37 9.93 27 223344 25012 79496005
Liver disorder 17.34 9.93 125 223246 72292 79448725
Intestinal perforation 17.33 9.93 14 223357 17412 79503605
Hyponatraemia 17.32 9.93 635 222736 177213 79343804
Soft tissue injury 17.14 9.93 23 223348 1758 79519259
Glomerular filtration rate increased 17.13 9.93 19 223352 1192 79519825
Sensory loss 17.11 9.93 77 223294 12914 79508103
Vitamin B12 increased 17.10 9.93 19 223352 1194 79519823
Dactylitis 17.10 9.93 29 223342 2728 79518289
Anaphylactic reaction 17.08 9.93 151 223220 83592 79437425
Neuropathy peripheral 16.94 9.93 517 222854 140788 79380229
Peritonitis 16.93 9.93 33 223338 28003 79493014
Sleep talking 16.91 9.93 18 223353 1078 79519939
Total cholesterol/HDL ratio abnormal 16.91 9.93 7 223364 78 79520939
Open reduction of fracture 16.89 9.93 10 223361 251 79520766
Hyponatraemic encephalopathy 16.87 9.93 11 223360 329 79520688
Ischaemic stroke 16.73 9.93 43 223328 33088 79487929
Prescribed overdose 16.72 9.93 171 223200 37712 79483305
Anaphylactic shock 16.48 9.93 49 223322 35947 79485070
Acute stress disorder 16.45 9.93 12 223359 432 79520585
Klebsiella infection 16.44 9.93 12 223359 15708 79505309
Hypercalcaemia 16.40 9.93 54 223317 38376 79482641
Claustrophobia 16.39 9.93 19 223352 1251 79519766
Metastases to lung 16.37 9.93 16 223355 18147 79502870
Scoliosis 16.29 9.93 52 223319 7412 79513605
Eye pain 16.29 9.93 169 223202 37409 79483608
Feelings of worthlessness 16.23 9.93 13 223358 539 79520478
Shock 16.07 9.93 65 223306 43483 79477534
Illness 16.02 9.93 200 223171 46311 79474706
Haemolysis 15.88 9.93 8 223363 12804 79508213
Intervertebral disc protrusion 15.86 9.93 117 223254 23504 79497513
Haematochezia 15.76 9.93 163 223208 87482 79433535
Atrioventricular block complete 15.72 9.93 14 223357 16596 79504421
Haemolytic anaemia 15.71 9.93 16 223355 17804 79503213
Facet joint syndrome 15.68 9.93 6 223365 11296 79509721
Granulomatous liver disease 15.65 9.93 19 223352 1314 79519703
Hepatic steatosis 15.55 9.93 168 223203 37570 79483447
Lacunar stroke 15.55 9.93 11 223360 377 79520640
Status epilepticus 15.53 9.93 29 223342 25012 79496005
Foetal exposure timing unspecified 15.52 9.93 6 223365 55 79520962
Dysarthria 15.50 9.93 271 223100 67351 79453666
Rales 15.43 9.93 20 223351 19981 79501036
Convulsive threshold lowered 15.41 9.93 16 223355 931 79520086
Poverty of speech 15.39 9.93 13 223358 581 79520436
Feeling hot 15.39 9.93 244 223127 59490 79461527
Rectal haemorrhage 15.37 9.93 138 223233 76162 79444855
Mobility decreased 15.36 9.93 245 223126 121930 79399087
Amenorrhoea 15.36 9.93 52 223319 7640 79513377
Pericardial effusion 15.25 9.93 72 223299 46165 79474852
Renal injury 15.15 9.93 15 223356 16912 79504105
Oliguria 15.13 9.93 14 223357 16295 79504722
Genital ulceration 15.12 9.93 17 223354 1083 79519934
Lymphoma 15.03 9.93 16 223355 17444 79503573
Ophthalmic vein thrombosis 15.02 9.93 9 223362 231 79520786
Progressive multifocal leukoencephalopathy 14.97 9.93 104 223267 20496 79500521
Hypervolaemia 14.96 9.93 65 223306 42625 79478392
Tearfulness 14.95 9.93 44 223327 6001 79515016
Burning sensation 14.91 9.93 239 223132 58393 79462624
Liver injury 14.91 9.93 95 223276 56519 79464498
Hysterectomy 14.90 9.93 45 223326 6227 79514790
Rhinalgia 14.81 9.93 25 223346 2342 79518675
Drug tolerance decreased 14.79 9.93 9 223362 12969 79508048
Myofascial pain syndrome 14.77 9.93 23 223348 2014 79519003
Uterine disorder 14.74 9.93 24 223347 2183 79518834
Clostridium difficile colitis 14.74 9.93 44 223327 32239 79488778
Atelectasis 14.70 9.93 44 223327 32213 79488804
Hepatic cytolysis 14.68 9.93 34 223337 27117 79493900
Complex regional pain syndrome 14.68 9.93 23 223348 2025 79518992
Thrombocytosis 14.66 9.93 3 223368 8523 79512494
Immobilisation prolonged 14.65 9.93 7 223364 112 79520905
Clitoral engorgement 14.64 9.93 3 223368 0 79521017
Dysstasia 14.60 9.93 130 223241 27616 79493401
Blood bilirubin increased 14.60 9.93 117 223254 66115 79454902
Throat irritation 14.50 9.93 177 223194 40769 79480248
Accidental death 14.43 9.93 35 223336 4256 79516761
Pulmonary haemorrhage 14.42 9.93 12 223359 14705 79506312
Coagulopathy 14.41 9.93 52 223319 35954 79485063
Angina unstable 14.39 9.93 15 223356 16512 79504505
Peripheral venous disease 14.36 9.93 14 223357 15895 79505122
Illness anxiety disorder 14.33 9.93 9 223362 252 79520765
Drug ineffective for unapproved indication 14.23 9.93 212 223159 51026 79469991
Bone density decreased 14.20 9.93 10 223361 13337 79507680
Cardiac murmur 14.19 9.93 14 223357 15810 79505207
Nephropathy toxic 14.18 9.93 22 223349 20397 79500620
Sinus tachycardia 14.15 9.93 162 223209 36746 79484271
Visual impairment 14.13 9.93 348 223023 91783 79429234
Spondyloarthropathy 14.11 9.93 16 223355 1029 79519988
Metastases to central nervous system 14.10 9.93 15 223356 16360 79504657
Hypnagogic hallucination 14.06 9.93 8 223363 186 79520831
Circulatory collapse 14.04 9.93 56 223315 37612 79483405
Drug metabolising enzyme decreased 14.01 9.93 4 223367 12 79521005
Anal incontinence 13.97 9.93 93 223278 18075 79502942
Hepatocellular carcinoma 13.90 9.93 4 223367 9017 79512000
Pneumonia fungal 13.90 9.93 7 223364 11203 79509814
Radiation fibrosis 13.87 9.93 5 223366 37 79520980
Gastric haemorrhage 13.87 9.93 13 223358 15037 79505980
Therapeutic product effect incomplete 13.85 9.93 506 222865 141139 79379878
Social avoidant behaviour 13.83 9.93 37 223334 4777 79516240
Bronchiectasis 13.82 9.93 26 223345 22360 79498657
Rheumatoid factor increased 13.82 9.93 21 223350 1800 79519217
Nephrotic syndrome 13.82 9.93 7 223364 11167 79509850
Obsessive-compulsive personality disorder 13.81 9.93 7 223364 128 79520889
Acute hepatic failure 13.78 9.93 41 223330 30072 79490945
Rapid eye movement sleep behaviour disorder 13.75 9.93 11 223360 455 79520562
Colitis 13.73 9.93 135 223236 73172 79447845
Rib fracture 13.72 9.93 129 223242 27818 79493199
Hypokinesia 13.72 9.93 96 223275 18964 79502053
Persistent genital arousal disorder 13.72 9.93 9 223362 272 79520745
Hypoglycaemia 13.70 9.93 201 223170 101393 79419624
Hyperuricaemia 13.70 9.93 8 223363 11791 79509226
Respiratory arrest 13.68 9.93 232 223139 57318 79463699
Pyometra 13.67 9.93 6 223365 78 79520939
Metastases to lymph nodes 13.65 9.93 6 223365 10391 79510626
Reversible airways obstruction 13.64 9.93 23 223348 2153 79518864
Chronic kidney disease 13.61 9.93 119 223252 66035 79454982
Sternal fracture 13.60 9.93 25 223346 2505 79518512
Febrile bone marrow aplasia 13.53 9.93 10 223361 13010 79508007
Intervertebral disc operation 13.52 9.93 15 223356 941 79520076
Urinary hesitation 13.50 9.93 34 223337 4232 79516785
Oesophagitis 13.47 9.93 30 223341 24259 79496758
Multiple-drug resistance 13.40 9.93 4 223367 8804 79512213
Extrapyramidal disorder 13.38 9.93 109 223262 22570 79498447
Cushingoid 13.37 9.93 5 223366 9547 79511470
Posterior reversible encephalopathy syndrome 13.35 9.93 34 223337 26247 79494770
Back disorder 13.33 9.93 66 223305 11512 79509505
Pulmonary toxicity 13.32 9.93 10 223361 12904 79508113
Post concussion syndrome 13.30 9.93 12 223359 586 79520431
Gambling 13.18 9.93 9 223362 291 79520726
Reaction to azo-dyes 13.13 9.93 4 223367 16 79521001
Illusion 13.10 9.93 20 223351 1721 79519296
Tachyphrenia 13.06 9.93 22 223349 2058 79518959
Colorectal cancer 13.02 9.93 4 223367 8643 79512374
Tuberculosis 13.00 9.93 14 223357 15184 79505833
Granulocyte count increased 12.99 9.93 17 223354 1268 79519749
Myocardial ischaemia 12.98 9.93 33 223338 25486 79495531
Embolism 12.97 9.93 12 223359 13970 79507047
Panic disorder 12.97 9.93 27 223344 2965 79518052
Transfusion 12.97 9.93 25 223346 21305 79499712
Economic problem 12.93 9.93 23 223348 2247 79518770
Escherichia infection 12.91 9.93 19 223352 17998 79503019
Pulse abnormal 12.91 9.93 29 223342 3355 79517662
Hyperventilation 12.89 9.93 50 223321 7849 79513168
Diplopia 12.88 9.93 147 223224 33319 79487698
Adiposis dolorosa 12.84 9.93 9 223362 304 79520713
Impulse-control disorder 12.82 9.93 20 223351 1754 79519263
Ventricular hypokinesia 12.75 9.93 5 223366 9274 79511743
Lupus-like syndrome 12.73 9.93 12 223359 13845 79507172
Seizure 12.73 9.93 649 222722 188185 79332832
Drug level decreased 12.62 9.93 13 223358 14389 79506628
Cardiac failure acute 12.57 9.93 21 223350 18908 79502109
Floating patella 12.57 9.93 3 223368 3 79521014
Psychopathic personality 12.57 9.93 3 223368 3 79521014
Acute graft versus host disease in skin 12.55 9.93 3 223368 7655 79513362
Movement disorder 12.49 9.93 124 223247 27135 79493882
Mean cell haemoglobin concentration increased 12.49 9.93 14 223357 889 79520128
Application site perspiration 12.41 9.93 4 223367 20 79520997
Serum serotonin increased 12.41 9.93 9 223362 321 79520696
Lymphoedema 12.38 9.93 68 223303 12345 79508672
Forced expiratory volume decreased 12.38 9.93 49 223322 7765 79513252
Facial spasm 12.36 9.93 13 223358 768 79520249
Right ventricular failure 12.25 9.93 30 223341 23467 79497550
Loose tooth 12.21 9.93 27 223344 3090 79517927
Back pain 12.21 9.93 1000 222371 303180 79217837
Vitamin D deficiency 12.15 9.93 75 223296 14204 79506813
Lung infiltration 12.14 9.93 29 223342 22883 79498134
Burning mouth syndrome 12.11 9.93 11 223360 542 79520475
Tongue movement disturbance 12.09 9.93 10 223361 434 79520583
Adverse event 12.09 9.93 109 223262 60105 79460912
Diarrhoea 12.03 9.93 2228 221143 878261 78642756
Sinus pain 12.03 9.93 30 223341 3712 79517305
Pregnancy 11.97 9.93 37 223334 26814 79494203
Infective pulmonary exacerbation of cystic fibrosis 11.96 9.93 11 223360 12840 79508177
Delirium 11.91 9.93 316 223055 84311 79436706
Hyperthyroidism 11.86 9.93 28 223343 22181 79498836
Trismus 11.85 9.93 38 223333 5429 79515588
Haemoglobin urine present 11.85 9.93 14 223357 941 79520076
Sciatic nerve injury 11.81 9.93 11 223360 560 79520457
Breast cancer stage II 11.79 9.93 4 223367 8116 79512901
Diffuse large B-cell lymphoma 11.79 9.93 10 223361 12139 79508878
Nasal polyps 11.76 9.93 3 223368 7324 79513693
Tachypnoea 11.74 9.93 48 223323 32015 79489002
Red blood cell sedimentation rate increased 11.64 9.93 78 223293 45864 79475153
Supraventricular tachyarrhythmia 11.63 9.93 6 223365 114 79520903
Foetal death 11.62 9.93 4 223367 8040 79512977
Panic reaction 11.58 9.93 34 223337 4631 79516386
Purple glove syndrome 11.57 9.93 8 223363 264 79520753
Trigger finger 11.57 9.93 32 223339 4213 79516804
Blood cholesterol increased 11.51 9.93 165 223206 83555 79437462
Dental restoration failure 11.51 9.93 14 223357 970 79520047
Skin plaque 11.50 9.93 8 223363 10737 79510280
Ligament injury 11.45 9.93 15 223356 1120 79519897
Somatic delusion 11.45 9.93 12 223359 706 79520311
Holmes-Adie pupil 11.41 9.93 4 223367 27 79520990
Heart rate decreased 11.36 9.93 134 223237 70182 79450835
Leukoencephalopathy 11.35 9.93 4 223367 7925 79513092
Menopausal symptoms 11.32 9.93 20 223351 1943 79519074
Dermatitis acneiform 11.29 9.93 7 223364 9986 79511031
Dysphemia 11.27 9.93 28 223343 3456 79517561
Axillary pain 11.26 9.93 21 223350 2128 79518889
Exposure via ingestion 11.25 9.93 36 223335 5138 79515879
Influenza 11.25 9.93 457 222914 129149 79391868
Impulsive behaviour 11.23 9.93 25 223346 2875 79518142
Withdrawal hypertension 11.20 9.93 9 223362 375 79520642
Incontinence 11.19 9.93 73 223298 14091 79506926
Blood bilirubin 11.16 9.93 4 223367 29 79520988
Product monitoring error 11.14 9.93 52 223319 8854 79512163
Forced expiratory flow decreased 11.14 9.93 8 223363 281 79520736
Skin lesion 11.13 9.93 70 223301 41774 79479243
Abulia 11.11 9.93 14 223357 1006 79520011
Pruritus 11.08 9.93 953 222418 393695 79127322
Hospitalisation 11.08 9.93 344 223027 93892 79427125
Hepatic cancer 11.06 9.93 8 223363 10521 79510496
Hypogammaglobulinaemia 11.00 9.93 12 223359 12939 79508078
Oesophageal food impaction 10.97 9.93 9 223362 386 79520631
Shock haemorrhagic 10.95 9.93 25 223346 20035 79500982
Apnoea 10.94 9.93 63 223308 11641 79509376
Binge eating 10.91 9.93 10 223361 499 79520518
Cachexia 10.90 9.93 9 223362 11074 79509943
Alveolar bone resorption 10.87 9.93 5 223366 73 79520944
Blood alkaline phosphatase increased 10.84 9.93 244 223127 63420 79457597
Paralogism 10.82 9.93 4 223367 32 79520985
Large intestine perforation 10.79 9.93 15 223356 14552 79506465
Bacterial infection 10.74 9.93 48 223323 31232 79489785
Hypophosphataemia 10.72 9.93 25 223346 19888 79501129
Polyarthritis 10.71 9.93 11 223360 12191 79508826
Blood prolactin increased 10.70 9.93 30 223341 3981 79517036
Rhabdomyolysis 10.69 9.93 214 223157 102917 79418100
Pulmonary arterial hypertension 10.68 9.93 42 223329 28324 79492693
Ocular vascular disorder 10.66 9.93 10 223361 514 79520503
Cytopenia 10.65 9.93 26 223345 20357 79500660
Meralgia paraesthetica 10.62 9.93 10 223361 516 79520501
Tendinous contracture 10.52 9.93 6 223365 140 79520877
Retrograde ejaculation 10.52 9.93 8 223363 307 79520710
Rectocele repair 10.51 9.93 3 223368 9 79521008
Cycloplegia 10.51 9.93 3 223368 9 79521008
Arthroscopy 10.50 9.93 10 223361 524 79520493
Device leakage 10.45 9.93 9 223362 10847 79510170
Hepatic function abnormal 10.44 9.93 143 223228 72964 79448053
Mental impairment 10.44 9.93 90 223281 18946 79502071
Pulmonary alveolar haemorrhage 10.43 9.93 10 223361 11447 79509570
Communication disorder 10.34 9.93 30 223341 4060 79516957
Systemic candida 10.28 9.93 3 223368 6703 79514314
Narcissistic personality disorder 10.27 9.93 3 223368 10 79521007
Therapeutic response unexpected 10.26 9.93 93 223278 19853 79501164
Cephalo-pelvic disproportion 10.23 9.93 6 223365 148 79520869
Injury 10.22 9.93 154 223217 77342 79443675
Activated partial thromboplastin time prolonged 10.20 9.93 15 223356 14213 79506804
Tachyphylaxis 10.17 9.93 8 223363 323 79520694
Bipolar I disorder 10.17 9.93 20 223351 2109 79518908
Hydronephrosis 10.15 9.93 21 223350 17433 79503584
Hepatic failure 10.14 9.93 116 223255 61096 79459921
Pulmonary hypertension 10.11 9.93 86 223285 47994 79473023
Staphylococcal sepsis 10.10 9.93 16 223355 14710 79506307
Physical assault 10.06 9.93 17 223354 1594 79519423
Sciatic nerve neuropathy 10.02 9.93 9 223362 437 79520580
Suspected suicide attempt 10.02 9.93 8 223363 330 79520687
Gastric ulcer 9.93 9.93 55 223316 33850 79487167

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Telangiectasia congenital 30.47 28.20 9 373 18 89392
Liver disorder 29.80 28.20 8 374 9 89401

Pharmacologic Action:

SourceCodeDescription
ATC N06AX21 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
MeSH PA D000068760 Serotonin and Noradrenaline Reuptake Inhibitors
FDA EPC N0000175749 Serotonin and Norepinephrine Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Female stress incontinence indication 60241006 DOID:724
Fibromyalgia indication 203082005 DOID:631
Major depressive disorder indication 370143000
Diabetic peripheral neuropathy indication 424736006
Chronic Musculoskeletal Pain indication
Osteoarthritis off-label use 396275006
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Jaundice contraindication 18165001
Cirrhosis of liver contraindication 19943007 DOID:5082
Orthostatic hypotension contraindication 28651003
Hypertensive disorder contraindication 38341003 DOID:10763
Alcoholic liver damage contraindication 41309000
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Chronic hepatitis contraindication 76783007 DOID:2237
Hyperglycemia contraindication 80394007 DOID:4195
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Inflammatory disease of liver contraindication 128241005
Liver function tests abnormal contraindication 166603001
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Serotonin syndrome contraindication 371089000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastrointestinal hypomotility contraindication 421807004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 20MG BASE CYMBALTA LILLY N021427 Aug. 3, 2004 RX CAPSULE, DELAYED REL PELLETS ORAL April 20, 2023 NEW PATIENT POPULATION
EQ 30MG BASE CYMBALTA LILLY N021427 Aug. 3, 2004 RX CAPSULE, DELAYED REL PELLETS ORAL April 20, 2023 NEW PATIENT POPULATION
EQ 60MG BASE CYMBALTA LILLY N021427 Aug. 3, 2004 RX CAPSULE, DELAYED REL PELLETS ORAL April 20, 2023 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 9.62 CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Ki 8.22 CHEMBL CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5.30 PDSP
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 6.30 IUPHAR
5-hydroxytryptamine receptor 2B GPCR Ki 5.68 PDSP
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 6 IUPHAR
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 7 GPCR Ki 5.65 PDSP
Histamine H1 receptor GPCR Ki 5.64 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 5.40 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.52 PDSP
Sodium-dependent dopamine transporter Transporter Ki 6.62 CHEMBL
5-hydroxytryptamine receptor 1F GPCR Ki 5.35 PDSP
5-hydroxytryptamine receptor 1E GPCR Ki 5.43 PDSP
Serine hydroxymethyltransferase, mitochondrial Enzyme IC50 5.16 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 10.09 CHEMBL
Sodium-dependent dopamine transporter Transporter IC50 6.43 CHEMBL
Transporter Transporter Ki 8.52 CHEMBL

External reference:

IDSource
D01179 KEGG_DRUG
136434-34-9 SECONDARY_CAS_RN
4021477 VANDF
C0245561 UMLSCUI
CHEBI:31526 CHEBI
29E PDB_CHEM_ID
CHEMBL1175 ChEMBL_ID
CHEMBL1200328 ChEMBL_ID
DB00476 DRUGBANK_ID
D000068736 MESH_DESCRIPTOR_UI
60835 PUBCHEM_CID
202 IUPHAR_LIGAND_ID
7012 INN_ID
O5TNM5N07U UNII
476250 RXNORM
18760 MMSL
208014 MMSL
33554 MMSL
59319 MMSL
d05355 MMSL
008705 NDDF
008707 NDDF
407032004 SNOMEDCT_US
407033009 SNOMEDCT_US
426892003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3235 CAPSULE, DELAYED RELEASE 20 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3235 CAPSULE, DELAYED RELEASE 20 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3240 CAPSULE, DELAYED RELEASE 30 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3240 CAPSULE, DELAYED RELEASE 30 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3270 CAPSULE, DELAYED RELEASE 60 mg ORAL NDA 36 sections
Cymbalta HUMAN PRESCRIPTION DRUG LABEL 1 0002-3270 CAPSULE, DELAYED RELEASE 60 mg ORAL NDA 36 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2890 CAPSULE, DELAYED RELEASE PELLETS 20 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2891 CAPSULE, DELAYED RELEASE PELLETS 30 mg ORAL ANDA 29 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2892 CAPSULE, DELAYED RELEASE PELLETS 60 mg ORAL ANDA 29 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8203 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8203 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8204 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8204 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8290 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8290 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Duloxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6452 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Duloxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6453 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 30 sections
Duloxetine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6454 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 30 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7043 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7043 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7044 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7044 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7045 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
Duloxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7045 CAPSULE, DELAYED RELEASE 60 mg ORAL ANDA 31 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-109 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-109 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-109 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-110 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 30 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-110 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 30 sections
Duloxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-110 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 30 sections