drotaverine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
spasmolytics with a papaverine-like action 969 14009-24-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dihydroisoperparine
  • drotaverin hydrochloride
  • drotaverine hydrochloride
  • drotaverine HCl
  • drotaverine
  • drotaverin
  • isodihydroperparine
Hungarian drug; RN given refers to parent cpd; structure
  • Molecular weight: 397.52
  • Formula: C24H31NO4
  • CLOGP: 5.23
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 1
  • TPSA: 48.95
  • ALOGS: -5.30
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.90 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 58 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AD02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Papaverine and derivatives
MeSH PA D000700 Analgesics
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel WOMBAT-PK
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Enzyme WOMBAT-PK

External reference:

IDSource
D07088 KEGG_DRUG
985-12-6 SECONDARY_CAS_RN
C0058762 UMLSCUI
CHEBI:135630 CHEBI
CHEMBL551978 ChEMBL_ID
DB06751 DRUGBANK_ID
C005317 MESH_SUPPLEMENTAL_RECORD_UI
1712095 PUBCHEM_CID
2239 INN_ID
98QS4N58TW UNII
23684 RXNORM
007309 NDDF
007310 NDDF
719933003 SNOMEDCT_US

Pharmaceutical products:

None