drostanolone propionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids not used as glucocorticosteroids	965	521-12-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: medrotestron metholone dromostanolone propionate emdisterone medrotestron propionate medrotestrone propanoate medrotestrone propionate prometholone permastril drostanolone propionate	synthetic anabolic androgenic steroid used to lower plasma cholesterol & as antineoplastic agent in advanced breast neoplasms; major descriptor (66-86); on-line search ANDROSTANOLS (80-86); ANDROSTANES (68-86); INDEX MEDICUS search DROMOSTANOLONE (66-86); RN given refers to (2alpha,5alpha,17beta)-isomer Molecular weight: 360.54 Formula: C23H36O3 CLOGP: 5.55 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 43.37 ALOGS: -5.76 ROTB: 3 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

medrotestron
metholone
dromostanolone propionate
emdisterone
medrotestron propionate
medrotestrone propanoate
medrotestrone propionate
prometholone
permastril
drostanolone propionate

synthetic anabolic androgenic steroid used to lower plasma cholesterol & as antineoplastic agent in advanced breast neoplasms; major descriptor (66-86); on-line search ANDROSTANOLS (80-86); ANDROSTANES (68-86); INDEX MEDICUS search DROMOSTANOLONE (66-86); RN given refers to (2alpha,5alpha,17beta)-isomer

Molecular weight: 360.54
Formula: C23H36O3
CLOGP: 5.55
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 43.37
ALOGS: -5.76
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:35610	antineoplastic agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Malignant neoplasm of breast	indication	254837009	DOID:1612

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN	AGONIST				DRUGBANK	CHEMBL

External reference:

ID	Source
D01534	KEGG_DRUG
CHEBI:31523	CHEBI
CHEBI:34838	CHEBI
CHEMBL1201048	ChEMBL_ID
C007561	MESH_SUPPLEMENTAL_RECORD_UI
C100263	MESH_SUPPLEMENTAL_RECORD_UI
6947	IUPHAR_LIGAND_ID
DB14655	DRUGBANK_ID
DB00858	DRUGBANK_ID
23678	RXNORM
002664	NDDF
004822	NDDF
417263004	SNOMEDCT_US
420633004	SNOMEDCT_US
420908004	SNOMEDCT_US
C0058758	UMLSCUI
C0058753	UMLSCUI
224004	PUBCHEM_CID
6011	PUBCHEM_CID
X20UZ57G4O	UNII

Pharmaceutical products:

None