Stem definition | Drug id | CAS RN |
---|---|---|
962 | 469-21-6 |
Dose | Unit | Route |
---|---|---|
25 | mg | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 24.70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
April 7, 1948 | FDA | SANOFI AVENTIS US |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2535.46 | 9.85 | 3616 | 316269 | 128273 | 50156966 |
Toxicity to various agents | 2113.18 | 9.85 | 4345 | 315540 | 208154 | 50077085 |
Infusion related reaction | 890.12 | 9.85 | 2721 | 317164 | 166836 | 50118403 |
Sinusitis | 670.48 | 9.85 | 2484 | 317401 | 168074 | 50117165 |
Muscle injury | 576.66 | 9.85 | 923 | 318962 | 36188 | 50249051 |
Folliculitis | 569.42 | 9.85 | 946 | 318939 | 38279 | 50246960 |
Exposure to toxic agent | 544.06 | 9.85 | 320 | 319565 | 3338 | 50281901 |
Acute hepatic failure | 505.79 | 9.85 | 558 | 319327 | 15119 | 50270120 |
Lower respiratory tract infection | 490.56 | 9.85 | 1519 | 318366 | 93682 | 50191557 |
Irritable bowel syndrome | 489.29 | 9.85 | 1035 | 318850 | 50406 | 50234833 |
Overdose | 424.09 | 9.85 | 1491 | 318394 | 98236 | 50187003 |
Blister | 380.46 | 9.85 | 1297 | 318588 | 84121 | 50201118 |
Sleep disorder due to general medical condition, insomnia type | 380.38 | 9.85 | 700 | 319185 | 30747 | 50254492 |
Ill-defined disorder | 379.55 | 9.85 | 972 | 318913 | 53682 | 50231557 |
Blood pressure fluctuation | 357.22 | 9.85 | 735 | 319150 | 35088 | 50250151 |
Intentional product misuse | 344.22 | 9.85 | 850 | 319035 | 45884 | 50239355 |
Metabolic acidosis | 338.13 | 9.85 | 754 | 319131 | 38071 | 50247168 |
Impaired healing | 318.96 | 9.85 | 1069 | 318816 | 68717 | 50216522 |
Duodenal ulcer perforation | 315.45 | 9.85 | 810 | 319075 | 44801 | 50240438 |
Anti-cyclic citrullinated peptide antibody positive | 315.32 | 9.85 | 1073 | 318812 | 69514 | 50215725 |
Joint swelling | 310.98 | 9.85 | 2628 | 317257 | 242658 | 50042581 |
Product dose omission issue | 309.42 | 9.85 | 426 | 319459 | 183412 | 50101827 |
Helicobacter infection | 308.62 | 9.85 | 848 | 319037 | 48854 | 50236385 |
Pericarditis | 294.45 | 9.85 | 1129 | 318756 | 77560 | 50207679 |
Hepatic enzyme increased | 280.39 | 9.85 | 1653 | 318232 | 135727 | 50149512 |
Injection site pain | 274.59 | 9.85 | 182 | 319703 | 110842 | 50174397 |
Rheumatoid arthritis | 265.55 | 9.85 | 2187 | 317698 | 200363 | 50084876 |
Nasopharyngitis | 258.77 | 9.85 | 2094 | 317791 | 190833 | 50094406 |
Therapeutic product effect decreased | 251.70 | 9.85 | 1596 | 318289 | 134454 | 50150785 |
Gastrointestinal disorder | 226.95 | 9.85 | 1188 | 318697 | 93268 | 50191971 |
Hepatotoxicity | 217.40 | 9.85 | 511 | 319374 | 26715 | 50258524 |
Stomatitis | 205.75 | 9.85 | 1218 | 318667 | 100126 | 50185113 |
Anion gap | 202.78 | 9.85 | 112 | 319773 | 1025 | 50284214 |
Diarrhoea | 198.64 | 9.85 | 2578 | 317307 | 585898 | 49699341 |
Intentional overdose | 195.07 | 9.85 | 848 | 319037 | 61656 | 50223583 |
Synovitis | 190.20 | 9.85 | 1388 | 318497 | 122477 | 50162762 |
Body temperature increased | 188.84 | 9.85 | 529 | 319356 | 30812 | 50254427 |
Intentional product use issue | 188.59 | 9.85 | 973 | 318912 | 75945 | 50209294 |
Hypersensitivity | 187.84 | 9.85 | 2133 | 317752 | 213028 | 50072211 |
Hand deformity | 183.08 | 9.85 | 1172 | 318713 | 99027 | 50186212 |
Swelling | 181.07 | 9.85 | 2004 | 317881 | 198868 | 50086371 |
Weight increased | 178.27 | 9.85 | 2006 | 317879 | 199885 | 50085354 |
Discomfort | 163.80 | 9.85 | 1210 | 318675 | 107170 | 50178069 |
Peripheral swelling | 157.52 | 9.85 | 1991 | 317894 | 203945 | 50081294 |
Wound | 155.84 | 9.85 | 1174 | 318711 | 104620 | 50180619 |
Medication error | 152.59 | 9.85 | 539 | 319346 | 35565 | 50249674 |
Injection site erythema | 152.52 | 9.85 | 149 | 319736 | 74787 | 50210452 |
Device expulsion | 149.23 | 9.85 | 8 | 319877 | 28814 | 50256425 |
Depressed level of consciousness | 147.20 | 9.85 | 685 | 319200 | 51268 | 50233971 |
Psoriasis | 142.99 | 9.85 | 135 | 319750 | 68865 | 50216374 |
Wrong technique in product usage process | 142.67 | 9.85 | 87 | 319798 | 55423 | 50229816 |
Coagulopathy | 135.92 | 9.85 | 330 | 319555 | 17614 | 50267625 |
Sedation complication | 134.68 | 9.85 | 217 | 319668 | 8549 | 50276690 |
Respiratory arrest | 134.63 | 9.85 | 457 | 319428 | 29552 | 50255687 |
Hepatic cytolysis | 133.35 | 9.85 | 207 | 319678 | 7896 | 50277343 |
Ear pain | 129.79 | 9.85 | 434 | 319451 | 27849 | 50257390 |
Heart rate decreased | 129.39 | 9.85 | 515 | 319370 | 35982 | 50249257 |
Injection site reaction | 122.32 | 9.85 | 83 | 319802 | 49949 | 50235290 |
Infection | 116.36 | 9.85 | 1634 | 318251 | 171320 | 50113919 |
Drug hypersensitivity | 115.62 | 9.85 | 1022 | 318863 | 249988 | 50035251 |
Creatinine renal clearance decreased | 115.14 | 9.85 | 241 | 319644 | 11640 | 50273599 |
Analgesic drug level increased | 112.71 | 9.85 | 91 | 319794 | 1640 | 50283599 |
Hepatic failure | 111.61 | 9.85 | 452 | 319433 | 31831 | 50253408 |
Blood pressure diastolic abnormal | 111.42 | 9.85 | 207 | 319678 | 9154 | 50276085 |
Cardio-respiratory arrest | 111.41 | 9.85 | 651 | 319234 | 53241 | 50231998 |
Rheumatoid factor positive | 110.78 | 9.85 | 614 | 319271 | 49245 | 50235994 |
Infusion site pain | 109.95 | 9.85 | 242 | 319643 | 12104 | 50273135 |
Muscle spasticity | 106.42 | 9.85 | 293 | 319592 | 16891 | 50268348 |
Pruritus | 104.70 | 9.85 | 2437 | 317448 | 281131 | 50004108 |
Anaemia | 104.67 | 9.85 | 1055 | 318830 | 251401 | 50033838 |
Confusional state | 103.22 | 9.85 | 1700 | 318185 | 184228 | 50101011 |
Infusion site swelling | 99.98 | 9.85 | 170 | 319715 | 7006 | 50278233 |
Injection site bruising | 96.77 | 9.85 | 56 | 319829 | 36712 | 50248527 |
Poisoning | 93.51 | 9.85 | 228 | 319657 | 12201 | 50273038 |
Injection site pruritus | 92.32 | 9.85 | 72 | 319813 | 40339 | 50244900 |
Cardiac failure congestive | 91.81 | 9.85 | 253 | 319632 | 84129 | 50201110 |
Blood calcium decreased | 91.71 | 9.85 | 314 | 319571 | 20392 | 50264847 |
Hepatic necrosis | 90.49 | 9.85 | 137 | 319748 | 5111 | 50280128 |
Blood pressure diastolic decreased | 90.25 | 9.85 | 272 | 319613 | 16509 | 50268730 |
Blood pressure systolic abnormal | 89.97 | 9.85 | 169 | 319716 | 7537 | 50277702 |
Acute lung injury | 88.11 | 9.85 | 72 | 319813 | 1321 | 50283918 |
Glossodynia | 87.65 | 9.85 | 1116 | 318769 | 114453 | 50170786 |
Disease progression | 86.34 | 9.85 | 313 | 319572 | 95553 | 50189686 |
Blood pressure increased | 85.98 | 9.85 | 1249 | 318636 | 131883 | 50153356 |
Neutropenia | 85.23 | 9.85 | 566 | 319319 | 147399 | 50137840 |
Drug ineffective | 83.91 | 9.85 | 4282 | 315603 | 815051 | 49470188 |
Hospitalisation | 83.78 | 9.85 | 191 | 319694 | 67746 | 50217493 |
Sopor | 83.19 | 9.85 | 13 | 319872 | 19866 | 50265373 |
Myocardial infarction | 81.95 | 9.85 | 288 | 319597 | 88739 | 50196500 |
Dizziness | 81.68 | 9.85 | 1621 | 318264 | 344748 | 49940491 |
Infusion site extravasation | 81.46 | 9.85 | 153 | 319732 | 6823 | 50278416 |
Product quality issue | 79.79 | 9.85 | 48 | 319837 | 30810 | 50254429 |
Respiratory depression | 79.61 | 9.85 | 210 | 319675 | 11800 | 50273439 |
Nausea | 78.90 | 9.85 | 3652 | 316233 | 701746 | 49583493 |
Suspected suicide | 78.76 | 9.85 | 130 | 319755 | 5227 | 50280012 |
Feeling abnormal | 78.47 | 9.85 | 468 | 319417 | 125024 | 50160215 |
Contraindicated product administered | 78.24 | 9.85 | 1350 | 318535 | 147608 | 50137631 |
Arthropathy | 77.93 | 9.85 | 1417 | 318468 | 156489 | 50128750 |
Drug resistance | 75.97 | 9.85 | 14 | 319871 | 18975 | 50266264 |
Osteonecrosis of jaw | 75.51 | 9.85 | 57 | 319828 | 32469 | 50252770 |
Decreased appetite | 75.42 | 9.85 | 859 | 319026 | 200064 | 50085175 |
Infusion site erythema | 75.39 | 9.85 | 169 | 319716 | 8558 | 50276681 |
Therapy cessation | 73.77 | 9.85 | 36 | 319849 | 25975 | 50259264 |
Exposure via ingestion | 72.38 | 9.85 | 89 | 319796 | 2714 | 50282525 |
Blood pressure systolic increased | 71.82 | 9.85 | 426 | 319459 | 35023 | 50250216 |
Neuropathy peripheral | 71.51 | 9.85 | 341 | 319544 | 96416 | 50188823 |
Muscle spasms | 71.43 | 9.85 | 482 | 319403 | 125071 | 50160168 |
Pemphigus | 71.23 | 9.85 | 1111 | 318774 | 119055 | 50166184 |
Oxygen saturation decreased | 71.06 | 9.85 | 742 | 319143 | 72506 | 50212733 |
Injection site swelling | 70.97 | 9.85 | 96 | 319789 | 41677 | 50243562 |
Throat irritation | 68.23 | 9.85 | 374 | 319511 | 29865 | 50255374 |
Cerebrovascular accident | 68.05 | 9.85 | 337 | 319548 | 94343 | 50190896 |
Therapeutic product effect incomplete | 67.36 | 9.85 | 323 | 319562 | 91192 | 50194047 |
Coma | 66.89 | 9.85 | 600 | 319285 | 56279 | 50228960 |
Orthostatic hypotension | 66.77 | 9.85 | 365 | 319520 | 29116 | 50256123 |
Paraesthesia | 66.23 | 9.85 | 466 | 319419 | 119777 | 50165462 |
Cognitive disorder | 65.67 | 9.85 | 491 | 319394 | 43632 | 50241607 |
Arthralgia | 65.44 | 9.85 | 3394 | 316491 | 435308 | 49849931 |
Pyrexia | 63.68 | 9.85 | 2975 | 316910 | 377228 | 49908011 |
Pyroglutamate increased | 63.13 | 9.85 | 37 | 319848 | 383 | 50284856 |
Cardiac failure | 62.84 | 9.85 | 257 | 319628 | 75783 | 50209456 |
Rash | 62.73 | 9.85 | 3372 | 316513 | 434099 | 49851140 |
Night sweats | 62.04 | 9.85 | 394 | 319491 | 33180 | 50252059 |
Malignant neoplasm progression | 61.61 | 9.85 | 222 | 319663 | 67902 | 50217337 |
Pyroglutamic acidosis | 61.31 | 9.85 | 37 | 319848 | 406 | 50284833 |
Sedation | 60.19 | 9.85 | 365 | 319520 | 30245 | 50254994 |
Infusion site pruritus | 59.85 | 9.85 | 97 | 319788 | 3840 | 50281399 |
Rheumatic fever | 59.76 | 9.85 | 238 | 319647 | 16629 | 50268610 |
No adverse event | 58.23 | 9.85 | 76 | 319809 | 33502 | 50251737 |
Oedema peripheral | 57.05 | 9.85 | 681 | 319204 | 157280 | 50127959 |
Product substitution issue | 57.02 | 9.85 | 10 | 319875 | 14047 | 50271192 |
Respiratory disorder | 57.02 | 9.85 | 365 | 319520 | 30822 | 50254417 |
Liver injury | 56.77 | 9.85 | 308 | 319577 | 24498 | 50260741 |
Electric shock | 56.50 | 9.85 | 49 | 319836 | 979 | 50284260 |
Drug interaction | 56.23 | 9.85 | 905 | 318980 | 198716 | 50086523 |
Hypotension | 54.27 | 9.85 | 1907 | 317978 | 233562 | 50051677 |
Injection site warmth | 53.83 | 9.85 | 11 | 319874 | 13855 | 50271384 |
Swollen joint count increased | 53.61 | 9.85 | 211 | 319674 | 14662 | 50270577 |
Product storage error | 53.47 | 9.85 | 7 | 319878 | 12217 | 50273022 |
Device malfunction | 52.81 | 9.85 | 15 | 319870 | 15106 | 50270133 |
Abortion spontaneous | 52.67 | 9.85 | 116 | 319769 | 41656 | 50243583 |
Surgery | 51.73 | 9.85 | 69 | 319816 | 30136 | 50255103 |
Bone marrow failure | 51.62 | 9.85 | 59 | 319826 | 27565 | 50257674 |
Contusion | 51.61 | 9.85 | 996 | 318889 | 111187 | 50174052 |
Interstitial lung disease | 50.29 | 9.85 | 170 | 319715 | 53006 | 50232233 |
Heart rate increased | 49.93 | 9.85 | 725 | 319160 | 76525 | 50208714 |
Accidental overdose | 49.16 | 9.85 | 249 | 319636 | 19284 | 50265955 |
Drug intolerance | 48.64 | 9.85 | 1767 | 318118 | 217337 | 50067902 |
Depression | 48.58 | 9.85 | 744 | 319141 | 164679 | 50120560 |
Mucosal inflammation | 48.56 | 9.85 | 114 | 319771 | 40028 | 50245211 |
Device dislocation | 48.44 | 9.85 | 39 | 319846 | 21507 | 50263732 |
Epistaxis | 48.06 | 9.85 | 224 | 319661 | 63730 | 50221509 |
Memory impairment | 47.48 | 9.85 | 300 | 319585 | 79060 | 50206179 |
Systemic lupus erythematosus | 47.37 | 9.85 | 1194 | 318691 | 139428 | 50145811 |
Unevaluable event | 47.25 | 9.85 | 142 | 319743 | 45924 | 50239315 |
Palmar-plantar erythrodysaesthesia syndrome | 46.94 | 9.85 | 35 | 319850 | 20063 | 50265176 |
Diabetes mellitus | 46.88 | 9.85 | 156 | 319729 | 48877 | 50236362 |
Crystal urine present | 46.73 | 9.85 | 52 | 319833 | 1422 | 50283817 |
International normalised ratio increased | 46.11 | 9.85 | 446 | 319439 | 42706 | 50242533 |
Red blood cell sedimentation rate abnormal | 45.77 | 9.85 | 23 | 319862 | 16320 | 50268919 |
White blood cells urine positive | 45.69 | 9.85 | 94 | 319791 | 4484 | 50280755 |
Heart rate irregular | 45.40 | 9.85 | 242 | 319643 | 19118 | 50266121 |
Anion gap abnormal | 45.36 | 9.85 | 28 | 319857 | 321 | 50284918 |
Bone pain | 45.34 | 9.85 | 150 | 319735 | 47079 | 50238160 |
Alanine aminotransferase increased | 44.99 | 9.85 | 797 | 319088 | 87562 | 50197677 |
Injection site rash | 44.95 | 9.85 | 23 | 319862 | 16154 | 50269085 |
Posterior reversible encephalopathy syndrome | 44.92 | 9.85 | 19 | 319866 | 14909 | 50270330 |
Drug abuse | 44.10 | 9.85 | 575 | 319310 | 59271 | 50225968 |
Infusion site bruising | 44.03 | 9.85 | 63 | 319822 | 2232 | 50283007 |
White blood cell count decreased | 43.75 | 9.85 | 499 | 319386 | 116223 | 50169016 |
Pancytopenia | 43.68 | 9.85 | 331 | 319554 | 83699 | 50201540 |
Body temperature decreased | 43.38 | 9.85 | 212 | 319673 | 16183 | 50269056 |
Suicide attempt | 42.83 | 9.85 | 508 | 319377 | 51224 | 50234015 |
Injection site haemorrhage | 42.77 | 9.85 | 43 | 319842 | 21303 | 50263936 |
Device issue | 41.45 | 9.85 | 39 | 319846 | 19933 | 50265306 |
Psoriatic arthropathy | 41.38 | 9.85 | 155 | 319730 | 46877 | 50238362 |
Injection site urticaria | 41.07 | 9.85 | 13 | 319872 | 12204 | 50273035 |
Malaise | 40.59 | 9.85 | 1721 | 318164 | 333811 | 49951428 |
Underdose | 40.46 | 9.85 | 41 | 319844 | 20237 | 50265002 |
Lymphocyte count decreased | 39.28 | 9.85 | 293 | 319592 | 26014 | 50259225 |
Urine abnormality | 39.25 | 9.85 | 107 | 319778 | 6131 | 50279108 |
Soft tissue disorder | 39.12 | 9.85 | 84 | 319801 | 4130 | 50281109 |
Respiratory rate increased | 39.02 | 9.85 | 159 | 319726 | 11226 | 50274013 |
Renal impairment | 38.87 | 9.85 | 299 | 319586 | 75362 | 50209877 |
Administration site swelling | 38.58 | 9.85 | 40 | 319845 | 1007 | 50284232 |
Seizure | 38.50 | 9.85 | 519 | 319366 | 117355 | 50167884 |
Neoplasm progression | 38.40 | 9.85 | 79 | 319806 | 29078 | 50256161 |
Dyspnoea exertional | 38.17 | 9.85 | 180 | 319705 | 51053 | 50234186 |
Suicidal ideation | 37.60 | 9.85 | 201 | 319684 | 55184 | 50230055 |
Mobility decreased | 37.16 | 9.85 | 711 | 319174 | 79237 | 50206002 |
Administration site pain | 37.03 | 9.85 | 32 | 319853 | 636 | 50284603 |
Injection site mass | 37.01 | 9.85 | 27 | 319858 | 15653 | 50269586 |
Transient ischaemic attack | 36.97 | 9.85 | 94 | 319791 | 32116 | 50253123 |
Gastrooesophageal reflux disease | 36.97 | 9.85 | 307 | 319578 | 76121 | 50209118 |
Poor venous access | 35.91 | 9.85 | 145 | 319740 | 10195 | 50275044 |
Rash pruritic | 35.70 | 9.85 | 168 | 319717 | 47678 | 50237561 |
Therapy interrupted | 35.57 | 9.85 | 45 | 319840 | 20107 | 50265132 |
Anxiety | 35.46 | 9.85 | 853 | 319032 | 176753 | 50108486 |
Vision blurred | 34.91 | 9.85 | 323 | 319562 | 78324 | 50206915 |
Blood pressure diastolic increased | 34.84 | 9.85 | 115 | 319770 | 7328 | 50277911 |
Fracture | 34.78 | 9.85 | 33 | 319852 | 16800 | 50268439 |
Product prescribing error | 34.77 | 9.85 | 49 | 319836 | 20912 | 50264327 |
Jaundice cholestatic | 34.52 | 9.85 | 90 | 319795 | 5021 | 50280218 |
Myelodysplastic syndrome | 34.51 | 9.85 | 27 | 319858 | 15105 | 50270134 |
Visual acuity reduced | 34.49 | 9.85 | 46 | 319839 | 20093 | 50265146 |
Infusion site nodule | 34.43 | 9.85 | 39 | 319846 | 1088 | 50284151 |
Urinary sediment present | 34.36 | 9.85 | 52 | 319833 | 1939 | 50283300 |
Device difficult to use | 34.17 | 9.85 | 10 | 319875 | 9876 | 50275363 |
Hyperkalaemia | 34.06 | 9.85 | 172 | 319713 | 47917 | 50237322 |
Tremor | 33.98 | 9.85 | 516 | 319369 | 114387 | 50170852 |
Blood parathyroid hormone decreased | 33.85 | 9.85 | 3 | 319882 | 7111 | 50278128 |
Urticaria | 33.82 | 9.85 | 1065 | 318820 | 128496 | 50156743 |
Drug ineffective for unapproved indication | 33.11 | 9.85 | 52 | 319833 | 21229 | 50264010 |
Dehydration | 33.01 | 9.85 | 723 | 319162 | 151726 | 50133513 |
Fall | 32.93 | 9.85 | 1756 | 318129 | 333176 | 49952063 |
Red blood cells urine positive | 32.57 | 9.85 | 61 | 319824 | 2714 | 50282525 |
Cardiac arrest | 32.34 | 9.85 | 724 | 319161 | 82927 | 50202312 |
Disturbance in attention | 32.07 | 9.85 | 96 | 319789 | 31090 | 50254149 |
Multiple sclerosis relapse | 31.39 | 9.85 | 152 | 319733 | 42812 | 50242427 |
Hyperlipidaemia | 30.93 | 9.85 | 39 | 319846 | 17451 | 50267788 |
Gait disturbance | 30.89 | 9.85 | 717 | 319168 | 149288 | 50135951 |
Therapeutic response unexpected | 30.83 | 9.85 | 33 | 319852 | 15882 | 50269357 |
Accidental exposure to product | 30.77 | 9.85 | 62 | 319823 | 22995 | 50262244 |
Red cell distribution width increased | 30.50 | 9.85 | 121 | 319764 | 8438 | 50276801 |
Palpitations | 30.18 | 9.85 | 418 | 319467 | 94088 | 50191151 |
Blood pH decreased | 30.11 | 9.85 | 55 | 319830 | 2400 | 50282839 |
Hypomania | 30.09 | 9.85 | 79 | 319806 | 4426 | 50280813 |
Dysgeusia | 30.01 | 9.85 | 135 | 319750 | 38781 | 50246458 |
Brain oedema | 29.95 | 9.85 | 156 | 319729 | 12214 | 50273025 |
Full blood count decreased | 29.89 | 9.85 | 60 | 319825 | 22286 | 50262953 |
Myelosuppression | 29.73 | 9.85 | 25 | 319860 | 13492 | 50271747 |
Loss of consciousness | 29.71 | 9.85 | 472 | 319413 | 103881 | 50181358 |
Intervertebral discitis | 29.46 | 9.85 | 57 | 319828 | 2599 | 50282640 |
Substance abuse | 29.28 | 9.85 | 74 | 319811 | 4050 | 50281189 |
Product use in unapproved indication | 29.05 | 9.85 | 536 | 319349 | 115283 | 50169956 |
Hyponatraemia | 29.02 | 9.85 | 430 | 319455 | 95709 | 50189530 |
Drug-induced liver injury | 28.85 | 9.85 | 288 | 319597 | 27807 | 50257432 |
Urine leukocyte esterase positive | 28.54 | 9.85 | 59 | 319826 | 2824 | 50282415 |
Neutrophil percentage increased | 28.41 | 9.85 | 57 | 319828 | 2670 | 50282569 |
Injection site induration | 28.11 | 9.85 | 9 | 319876 | 8388 | 50276851 |
Body temperature fluctuation | 27.83 | 9.85 | 47 | 319838 | 1926 | 50283313 |
Breast cancer | 27.82 | 9.85 | 158 | 319727 | 42732 | 50242507 |
Ear pruritus | 27.77 | 9.85 | 54 | 319831 | 2472 | 50282767 |
Hypokalaemia | 27.45 | 9.85 | 391 | 319494 | 87601 | 50197638 |
Coronary artery disease | 27.45 | 9.85 | 96 | 319789 | 29630 | 50255609 |
Myalgia | 27.37 | 9.85 | 588 | 319297 | 123731 | 50161508 |
Pain in extremity | 27.29 | 9.85 | 1428 | 318457 | 271437 | 50013802 |
Multiple drug therapy | 27.13 | 9.85 | 46 | 319839 | 1891 | 50283348 |
Hypertensive crisis | 26.93 | 9.85 | 26 | 319859 | 13128 | 50272111 |
Acute kidney injury | 26.85 | 9.85 | 1173 | 318712 | 226885 | 50058354 |
Gestational diabetes | 26.83 | 9.85 | 7 | 319878 | 7458 | 50277781 |
Pneumonia | 26.82 | 9.85 | 2044 | 317841 | 376357 | 49908882 |
Lymphocyte percentage decreased | 26.76 | 9.85 | 56 | 319829 | 2704 | 50282535 |
Pain | 26.64 | 9.85 | 4107 | 315778 | 574796 | 49710443 |
Incorrect drug administration rate | 26.59 | 9.85 | 54 | 319831 | 2552 | 50282687 |
Burning sensation | 26.56 | 9.85 | 173 | 319712 | 45273 | 50239966 |
Dry skin | 26.48 | 9.85 | 162 | 319723 | 43029 | 50242210 |
Liver transplant | 26.45 | 9.85 | 48 | 319837 | 2084 | 50283155 |
Brain death | 26.44 | 9.85 | 56 | 319829 | 2727 | 50282512 |
Musculoskeletal disorder | 26.42 | 9.85 | 43 | 319842 | 17306 | 50267933 |
Thrombocytopenia | 26.36 | 9.85 | 610 | 319275 | 127063 | 50158176 |
Iron deficiency anaemia | 26.32 | 9.85 | 41 | 319844 | 16793 | 50268446 |
Infusion site haemorrhage | 25.75 | 9.85 | 58 | 319827 | 2946 | 50282293 |
Atrial fibrillation | 25.47 | 9.85 | 471 | 319414 | 101274 | 50183965 |
Blood creatine increased | 25.14 | 9.85 | 78 | 319807 | 4809 | 50280430 |
Analgesic drug level above therapeutic | 24.90 | 9.85 | 15 | 319870 | 164 | 50285075 |
Specific gravity urine decreased | 24.87 | 9.85 | 26 | 319859 | 661 | 50284578 |
Femur fracture | 24.85 | 9.85 | 137 | 319748 | 37327 | 50247912 |
Ageusia | 24.77 | 9.85 | 22 | 319863 | 11561 | 50273678 |
Drug withdrawal syndrome | 24.52 | 9.85 | 79 | 319806 | 25002 | 50260237 |
Aspartate aminotransferase increased | 24.42 | 9.85 | 656 | 319229 | 77342 | 50207897 |
Anion gap increased | 24.25 | 9.85 | 38 | 319847 | 1461 | 50283778 |
Acidosis | 24.09 | 9.85 | 128 | 319757 | 10099 | 50275140 |
Epilepsy | 23.94 | 9.85 | 64 | 319821 | 21503 | 50263736 |
Hypercalcaemia | 23.93 | 9.85 | 72 | 319813 | 23280 | 50261959 |
Diabetic ketoacidosis | 23.89 | 9.85 | 48 | 319837 | 17824 | 50267415 |
Accidental death | 23.88 | 9.85 | 41 | 319844 | 1703 | 50283536 |
Cytokine release syndrome | 23.82 | 9.85 | 113 | 319772 | 8521 | 50276718 |
Platelet count decreased | 23.77 | 9.85 | 471 | 319414 | 100255 | 50184984 |
Withdrawal syndrome | 23.73 | 9.85 | 47 | 319838 | 17543 | 50267696 |
Macular degeneration | 23.65 | 9.85 | 164 | 319721 | 14224 | 50271015 |
Gastrointestinal haemorrhage | 23.51 | 9.85 | 324 | 319561 | 72997 | 50212242 |
Hypothermia | 23.44 | 9.85 | 143 | 319742 | 11873 | 50273366 |
Infusion site mass | 23.28 | 9.85 | 33 | 319852 | 1159 | 50284080 |
Thinking abnormal | 23.20 | 9.85 | 16 | 319869 | 9551 | 50275688 |
Prothrombin time prolonged | 23.18 | 9.85 | 114 | 319771 | 8724 | 50276515 |
Spinal stenosis | 23.15 | 9.85 | 31 | 319854 | 13519 | 50271720 |
Syncope | 23.01 | 9.85 | 486 | 319399 | 102516 | 50182723 |
Blood cholesterol increased | 22.97 | 9.85 | 483 | 319402 | 54732 | 50230507 |
Full blood count abnormal | 22.64 | 9.85 | 74 | 319811 | 23314 | 50261925 |
Administration site erythema | 22.58 | 9.85 | 22 | 319863 | 513 | 50284726 |
Aphasia | 22.48 | 9.85 | 98 | 319787 | 28396 | 50256843 |
Leukopenia | 22.16 | 9.85 | 297 | 319588 | 67231 | 50218008 |
Renal failure | 22.14 | 9.85 | 509 | 319376 | 106124 | 50179115 |
Second primary malignancy | 22.12 | 9.85 | 8 | 319877 | 6906 | 50278333 |
Genital haemorrhage | 22.09 | 9.85 | 7 | 319878 | 6567 | 50278672 |
Metastases to liver | 22.06 | 9.85 | 60 | 319825 | 20044 | 50265195 |
Hypoaesthesia | 21.99 | 9.85 | 624 | 319261 | 126633 | 50158606 |
Septic shock | 21.97 | 9.85 | 243 | 319642 | 56932 | 50228307 |
Metastases to bone | 21.85 | 9.85 | 51 | 319834 | 17944 | 50267295 |
Cytomegalovirus infection | 21.73 | 9.85 | 51 | 319834 | 17911 | 50267328 |
Complication associated with device | 21.68 | 9.85 | 37 | 319848 | 14618 | 50270621 |
Irritability | 21.68 | 9.85 | 99 | 319786 | 28327 | 50256912 |
Lupus-like syndrome | 21.56 | 9.85 | 17 | 319868 | 9474 | 50275765 |
Abdominal distension | 21.33 | 9.85 | 328 | 319557 | 72575 | 50212664 |
Respiratory failure | 21.32 | 9.85 | 427 | 319458 | 90754 | 50194485 |
Infusion site urticaria | 21.30 | 9.85 | 29 | 319856 | 980 | 50284259 |
Hypocalcaemia | 21.30 | 9.85 | 92 | 319793 | 26724 | 50258515 |
Mood swings | 21.20 | 9.85 | 43 | 319842 | 15911 | 50269328 |
Basal cell carcinoma | 21.18 | 9.85 | 76 | 319809 | 23280 | 50261959 |
Sepsis | 21.18 | 9.85 | 659 | 319226 | 132266 | 50152973 |
Joint stiffness | 21.12 | 9.85 | 109 | 319776 | 30199 | 50255040 |
Haemorrhage | 20.99 | 9.85 | 226 | 319659 | 53215 | 50232024 |
Ductus arteriosus premature closure | 20.93 | 9.85 | 17 | 319868 | 309 | 50284930 |
Tinnitus | 20.85 | 9.85 | 99 | 319786 | 28033 | 50257206 |
Blood glucose increased | 20.84 | 9.85 | 321 | 319564 | 71003 | 50214236 |
Pneumocystis jirovecii pneumonia | 20.81 | 9.85 | 38 | 319847 | 14625 | 50270614 |
Haematotoxicity | 20.81 | 9.85 | 12 | 319873 | 7883 | 50277356 |
Dysphonia | 20.77 | 9.85 | 152 | 319733 | 38740 | 50246499 |
Osteoarthritis | 20.65 | 9.85 | 307 | 319578 | 68299 | 50216940 |
Cardiac disorder | 20.61 | 9.85 | 173 | 319712 | 42806 | 50242433 |
Osteonecrosis | 20.60 | 9.85 | 73 | 319812 | 22444 | 50262795 |
Skin necrosis | 20.53 | 9.85 | 23 | 319862 | 10844 | 50274395 |
Disease recurrence | 20.52 | 9.85 | 62 | 319823 | 20019 | 50265220 |
Therapeutic response decreased | 20.51 | 9.85 | 195 | 319690 | 47036 | 50238203 |
Swollen tongue | 20.50 | 9.85 | 102 | 319783 | 28528 | 50256711 |
Carpal tunnel syndrome | 20.41 | 9.85 | 48 | 319837 | 16845 | 50268394 |
Concomitant disease aggravated | 20.34 | 9.85 | 13 | 319872 | 8078 | 50277161 |
Pulmonary hypertension | 20.14 | 9.85 | 126 | 319759 | 33291 | 50251948 |
Extrapyramidal disorder | 20.04 | 9.85 | 27 | 319858 | 11743 | 50273496 |
Blood urine present | 19.77 | 9.85 | 144 | 319741 | 12689 | 50272550 |
Bone erosion | 19.70 | 9.85 | 27 | 319858 | 11660 | 50273579 |
Bradypnoea | 19.61 | 9.85 | 53 | 319832 | 3021 | 50282218 |
Temperature regulation disorder | 19.51 | 9.85 | 65 | 319820 | 4162 | 50281077 |
Pathogen resistance | 19.22 | 9.85 | 6 | 319879 | 5683 | 50279556 |
Blood creatinine decreased | 19.08 | 9.85 | 72 | 319813 | 4904 | 50280335 |
Haemolysis | 19.04 | 9.85 | 82 | 319803 | 5934 | 50279305 |
Off label use | 19.03 | 9.85 | 2669 | 317216 | 471757 | 49813482 |
Body height decreased | 18.95 | 9.85 | 17 | 319868 | 8891 | 50276348 |
Asthma | 18.95 | 9.85 | 425 | 319460 | 88912 | 50196327 |
Chest pain | 18.95 | 9.85 | 919 | 318966 | 175963 | 50109276 |
Hepatic cirrhosis | 18.88 | 9.85 | 53 | 319832 | 17524 | 50267715 |
Foetal exposure during pregnancy | 18.73 | 9.85 | 99 | 319786 | 27260 | 50257979 |
Vitamin D deficiency | 18.57 | 9.85 | 27 | 319858 | 11375 | 50273864 |
Neurotoxicity | 18.52 | 9.85 | 41 | 319844 | 14699 | 50270540 |
Hemivertebra | 18.44 | 9.85 | 11 | 319874 | 118 | 50285121 |
Panniculitis | 18.36 | 9.85 | 16 | 319869 | 8487 | 50276752 |
Flatulence | 18.32 | 9.85 | 110 | 319775 | 29348 | 50255891 |
Bacterial test | 18.26 | 9.85 | 29 | 319856 | 1128 | 50284111 |
Smear cervix abnormal | 18.24 | 9.85 | 48 | 319837 | 2693 | 50282546 |
Heavy menstrual bleeding | 18.10 | 9.85 | 45 | 319840 | 15492 | 50269747 |
Product adhesion issue | 18.09 | 9.85 | 3 | 319882 | 4389 | 50280850 |
Infusion site irritation | 18.03 | 9.85 | 21 | 319864 | 604 | 50284635 |
Speech disorder | 18.01 | 9.85 | 141 | 319744 | 35407 | 50249832 |
Cerebral haemorrhage | 17.90 | 9.85 | 99 | 319786 | 26953 | 50258286 |
Hallucination, auditory | 17.87 | 9.85 | 25 | 319860 | 10703 | 50274536 |
Acute myocardial infarction | 17.84 | 9.85 | 110 | 319775 | 29163 | 50256076 |
Injection site discolouration | 17.82 | 9.85 | 11 | 319874 | 6963 | 50278276 |
Osmolar gap | 17.79 | 9.85 | 10 | 319875 | 95 | 50285144 |
Hepatic encephalopathy | 17.75 | 9.85 | 113 | 319772 | 9523 | 50275716 |
Post procedural pulmonary embolism | 17.68 | 9.85 | 14 | 319871 | 245 | 50284994 |
Fluid retention | 17.63 | 9.85 | 220 | 319665 | 50429 | 50234810 |
Polyneuropathy | 17.61 | 9.85 | 31 | 319854 | 12100 | 50273139 |
Taste disorder | 17.57 | 9.85 | 16 | 319869 | 8308 | 50276931 |
Hepatitis cholestatic | 17.57 | 9.85 | 81 | 319804 | 6036 | 50279203 |
Skin ulcer | 17.47 | 9.85 | 141 | 319744 | 35177 | 50250062 |
Angioedema | 17.47 | 9.85 | 153 | 319732 | 37523 | 50247716 |
Mean cell haemoglobin concentration increased | 17.46 | 9.85 | 18 | 319867 | 450 | 50284789 |
Thrombosis | 17.44 | 9.85 | 248 | 319637 | 55585 | 50229654 |
Oral discomfort | 17.42 | 9.85 | 15 | 319870 | 8002 | 50277237 |
Blood bilirubin increased | 17.38 | 9.85 | 292 | 319593 | 31746 | 50253493 |
Eye pruritus | 17.33 | 9.85 | 33 | 319852 | 12501 | 50272738 |
C-reactive protein abnormal | 17.21 | 9.85 | 104 | 319781 | 27705 | 50257534 |
Skin exfoliation | 17.18 | 9.85 | 133 | 319752 | 33479 | 50251760 |
Renal failure neonatal | 17.11 | 9.85 | 12 | 319873 | 173 | 50285066 |
Therapeutic response shortened | 17.08 | 9.85 | 92 | 319793 | 7297 | 50277942 |
Ventricular extrasystoles | 17.03 | 9.85 | 25 | 319860 | 10491 | 50274748 |
Laboratory test abnormal | 17.01 | 9.85 | 82 | 319803 | 23126 | 50262113 |
Bursitis | 16.86 | 9.85 | 214 | 319671 | 21921 | 50263318 |
Electrolyte imbalance | 16.84 | 9.85 | 54 | 319831 | 17115 | 50268124 |
Hyperglycaemia | 16.81 | 9.85 | 148 | 319737 | 36257 | 50248982 |
Cardiomyopathy | 16.74 | 9.85 | 47 | 319838 | 15539 | 50269700 |
Infusion site discomfort | 16.69 | 9.85 | 24 | 319861 | 854 | 50284385 |
Respiratory tract congestion | 16.64 | 9.85 | 41 | 319844 | 14158 | 50271081 |
Vertigo | 16.63 | 9.85 | 229 | 319656 | 51603 | 50233636 |
Unresponsive to stimuli | 16.61 | 9.85 | 279 | 319606 | 30330 | 50254909 |
COVID-19 immunisation | 16.60 | 9.85 | 22 | 319863 | 724 | 50284515 |
Pulmonary arterial hypertension | 16.57 | 9.85 | 69 | 319816 | 20250 | 50264989 |
Arrhythmia | 16.51 | 9.85 | 132 | 319753 | 33000 | 50252239 |
Fear of injection | 16.48 | 9.85 | 9 | 319876 | 6094 | 50279145 |
Asphyxia | 16.43 | 9.85 | 73 | 319812 | 5354 | 50279885 |
Prothrombin time shortened | 16.37 | 9.85 | 34 | 319851 | 1633 | 50283606 |
Drug screen positive | 16.31 | 9.85 | 53 | 319832 | 3349 | 50281890 |
Right ventricular failure | 16.29 | 9.85 | 49 | 319836 | 15844 | 50269395 |
Rhinitis allergic | 16.23 | 9.85 | 13 | 319872 | 7187 | 50278052 |
Device breakage | 16.15 | 9.85 | 22 | 319863 | 9525 | 50275714 |
Schizoaffective disorder | 16.10 | 9.85 | 40 | 319845 | 2166 | 50283073 |
Febrile bone marrow aplasia | 16.06 | 9.85 | 10 | 319875 | 6301 | 50278938 |
Meniscus injury | 16.02 | 9.85 | 10 | 319875 | 6292 | 50278947 |
Akathisia | 16.01 | 9.85 | 17 | 319868 | 8212 | 50277027 |
Sleep apnoea syndrome | 15.98 | 9.85 | 87 | 319798 | 23781 | 50261458 |
Band neutrophil count increased | 15.89 | 9.85 | 15 | 319870 | 336 | 50284903 |
Schizophrenia | 15.70 | 9.85 | 90 | 319795 | 7307 | 50277932 |
Pericardial effusion | 15.67 | 9.85 | 96 | 319789 | 25493 | 50259746 |
Lactic acidosis | 15.66 | 9.85 | 135 | 319750 | 33220 | 50252019 |
Hypothyroidism | 15.63 | 9.85 | 139 | 319746 | 33986 | 50251253 |
Metastases to lymph nodes | 15.43 | 9.85 | 13 | 319872 | 7011 | 50278228 |
Transplant rejection | 15.41 | 9.85 | 23 | 319862 | 9586 | 50275653 |
Hallucination | 15.38 | 9.85 | 205 | 319680 | 46452 | 50238787 |
Inappropriate antidiuretic hormone secretion | 15.36 | 9.85 | 38 | 319847 | 13105 | 50272134 |
Haemoglobin urine present | 15.28 | 9.85 | 22 | 319863 | 784 | 50284455 |
Dysphagia | 15.26 | 9.85 | 373 | 319512 | 77145 | 50208094 |
Uterine perforation | 15.20 | 9.85 | 11 | 319874 | 6404 | 50278835 |
Ascites | 15.17 | 9.85 | 149 | 319736 | 35712 | 50249527 |
Vaginal haemorrhage | 15.09 | 9.85 | 92 | 319793 | 24459 | 50260780 |
Intentional self-injury | 15.07 | 9.85 | 85 | 319800 | 23027 | 50262212 |
Pneumonia viral | 15.06 | 9.85 | 84 | 319801 | 6750 | 50278489 |
Transfusion-related acute lung injury | 15.05 | 9.85 | 9 | 319876 | 97 | 50285142 |
Culture urine positive | 14.99 | 9.85 | 52 | 319833 | 3399 | 50281840 |
Lung neoplasm malignant | 14.98 | 9.85 | 49 | 319836 | 15435 | 50269804 |
Loss of personal independence in daily activities | 14.92 | 9.85 | 333 | 319552 | 69717 | 50215522 |
Toxicologic test abnormal | 14.84 | 9.85 | 19 | 319866 | 604 | 50284635 |
Dyspnoea | 14.80 | 9.85 | 3148 | 316737 | 544460 | 49740779 |
Complication of device removal | 14.79 | 9.85 | 4 | 319881 | 4160 | 50281079 |
Renal papillary necrosis | 14.74 | 9.85 | 12 | 319873 | 219 | 50285020 |
Administration site pruritus | 14.69 | 9.85 | 13 | 319872 | 267 | 50284972 |
Treatment noncompliance | 14.62 | 9.85 | 121 | 319764 | 30029 | 50255210 |
Sensitivity to weather change | 14.60 | 9.85 | 10 | 319875 | 5991 | 50279248 |
Abnormal dreams | 14.50 | 9.85 | 23 | 319862 | 9354 | 50275885 |
Intermenstrual bleeding | 14.50 | 9.85 | 13 | 319872 | 6801 | 50278438 |
Pain in jaw | 14.50 | 9.85 | 164 | 319721 | 38264 | 50246975 |
Haemophagocytic lymphohistiocytosis | 14.50 | 9.85 | 20 | 319865 | 8613 | 50276626 |
Nail bed inflammation | 14.49 | 9.85 | 15 | 319870 | 377 | 50284862 |
Parosmia | 14.42 | 9.85 | 5 | 319880 | 4431 | 50280808 |
Weight decreased | 14.42 | 9.85 | 1203 | 318682 | 220042 | 50065197 |
Metastases to lung | 14.39 | 9.85 | 30 | 319855 | 10990 | 50274249 |
Gait inability | 14.37 | 9.85 | 157 | 319728 | 36870 | 50248369 |
Galactorrhoea | 14.36 | 9.85 | 3 | 319882 | 3720 | 50281519 |
Gout | 14.33 | 9.85 | 32 | 319853 | 11438 | 50273801 |
Pregnancy with contraceptive device | 14.33 | 9.85 | 4 | 319881 | 4075 | 50281164 |
Intervertebral disc degeneration | 14.16 | 9.85 | 41 | 319844 | 13420 | 50271819 |
Administration site extravasation | 14.14 | 9.85 | 20 | 319865 | 701 | 50284538 |
Product residue present | 14.07 | 9.85 | 3 | 319882 | 3669 | 50281570 |
Lip swelling | 14.03 | 9.85 | 95 | 319790 | 24641 | 50260598 |
Angina unstable | 14.03 | 9.85 | 13 | 319872 | 6693 | 50278546 |
Macular oedema | 13.98 | 9.85 | 3 | 319882 | 3651 | 50281588 |
Drug use disorder | 13.96 | 9.85 | 47 | 319838 | 3025 | 50282214 |
Skin burning sensation | 13.92 | 9.85 | 27 | 319858 | 10158 | 50275081 |
Infusion site rash | 13.92 | 9.85 | 28 | 319857 | 1314 | 50283925 |
Dyskinesia | 13.88 | 9.85 | 111 | 319774 | 27750 | 50257489 |
Eosinophil percentage increased | 13.75 | 9.85 | 23 | 319862 | 935 | 50284304 |
Acute graft versus host disease | 13.69 | 9.85 | 4 | 319881 | 3954 | 50281285 |
Immune reconstitution inflammatory syndrome | 13.68 | 9.85 | 9 | 319876 | 5507 | 50279732 |
Vitamin K deficiency | 13.54 | 9.85 | 15 | 319870 | 408 | 50284831 |
Colon gangrene | 13.53 | 9.85 | 4 | 319881 | 4 | 50285235 |
Blood uric acid decreased | 13.49 | 9.85 | 19 | 319866 | 663 | 50284576 |
Poisoning deliberate | 13.49 | 9.85 | 91 | 319794 | 7821 | 50277418 |
Coma hepatic | 13.45 | 9.85 | 18 | 319867 | 598 | 50284641 |
Pre-existing condition improved | 13.43 | 9.85 | 15 | 319870 | 7082 | 50278157 |
Large intestine polyp | 13.33 | 9.85 | 16 | 319869 | 7316 | 50277923 |
Ductus arteriosus stenosis foetal | 13.33 | 9.85 | 10 | 319875 | 161 | 50285078 |
Cerebral infarction | 13.26 | 9.85 | 81 | 319804 | 21523 | 50263716 |
Blindness | 13.26 | 9.85 | 60 | 319825 | 17209 | 50268030 |
Ejection fraction decreased | 13.25 | 9.85 | 66 | 319819 | 18454 | 50266785 |
Post transplant lymphoproliferative disorder | 13.22 | 9.85 | 5 | 319880 | 4199 | 50281040 |
Blood lactic acid increased | 13.22 | 9.85 | 70 | 319815 | 5515 | 50279724 |
Anaphylactic shock | 13.20 | 9.85 | 74 | 319811 | 20081 | 50265158 |
Mental impairment | 13.17 | 9.85 | 36 | 319849 | 12008 | 50273231 |
Tardive dyskinesia | 13.11 | 9.85 | 16 | 319869 | 7263 | 50277976 |
Ischaemic stroke | 13.10 | 9.85 | 54 | 319831 | 15894 | 50269345 |
Chronic kidney disease | 13.01 | 9.85 | 175 | 319710 | 39596 | 50245643 |
Antidepressant drug level above therapeutic | 12.99 | 9.85 | 14 | 319871 | 369 | 50284870 |
Cardiac failure acute | 12.98 | 9.85 | 20 | 319865 | 8230 | 50277009 |
Low density lipoprotein increased | 12.97 | 9.85 | 10 | 319875 | 5636 | 50279603 |
Alpha 1 microglobulin increased | 12.96 | 9.85 | 7 | 319878 | 61 | 50285178 |
Invasive ductal breast carcinoma | 12.96 | 9.85 | 11 | 319874 | 5910 | 50279329 |
Glycosylated haemoglobin increased | 12.92 | 9.85 | 30 | 319855 | 10576 | 50274663 |
Sputum culture positive | 12.91 | 9.85 | 28 | 319857 | 1386 | 50283853 |
Coagulation factor X level decreased | 12.87 | 9.85 | 7 | 319878 | 62 | 50285177 |
Shoulder arthroplasty | 12.85 | 9.85 | 3 | 319882 | 3445 | 50281794 |
Pulmonary embolism | 12.81 | 9.85 | 519 | 319366 | 101185 | 50184054 |
Urine analysis abnormal | 12.79 | 9.85 | 58 | 319827 | 4292 | 50280947 |
Administration site bruise | 12.77 | 9.85 | 12 | 319873 | 267 | 50284972 |
Product complaint | 12.75 | 9.85 | 34 | 319851 | 11432 | 50273807 |
Oedema | 12.66 | 9.85 | 342 | 319543 | 69839 | 50215400 |
Pneumonia aspiration | 12.63 | 9.85 | 130 | 319755 | 30874 | 50254365 |
Impaired work ability | 12.62 | 9.85 | 44 | 319841 | 13596 | 50271643 |
Skin infection | 12.62 | 9.85 | 126 | 319759 | 12165 | 50273074 |
Balance disorder | 12.54 | 9.85 | 556 | 319329 | 70034 | 50215205 |
Transplant dysfunction | 12.51 | 9.85 | 7 | 319878 | 4677 | 50280562 |
Hemiplegia | 12.50 | 9.85 | 17 | 319868 | 7364 | 50277875 |
Pancreatitis | 12.37 | 9.85 | 192 | 319693 | 42422 | 50242817 |
Impaired quality of life | 12.36 | 9.85 | 12 | 319873 | 6044 | 50279195 |
Deafness | 12.36 | 9.85 | 54 | 319831 | 15637 | 50269602 |
Foot operation | 12.35 | 9.85 | 10 | 319875 | 5500 | 50279739 |
Thrombotic microangiopathy | 12.28 | 9.85 | 23 | 319862 | 8768 | 50276471 |
Product physical issue | 12.28 | 9.85 | 6 | 319879 | 4326 | 50280913 |
Cells in urine | 12.26 | 9.85 | 10 | 319875 | 183 | 50285056 |
Coagulation factor VII level decreased | 12.23 | 9.85 | 7 | 319878 | 69 | 50285170 |
Atypical femur fracture | 12.22 | 9.85 | 8 | 319877 | 4908 | 50280331 |
Type 2 diabetes mellitus | 12.19 | 9.85 | 294 | 319591 | 34081 | 50251158 |
Eating disorder | 12.15 | 9.85 | 53 | 319832 | 15356 | 50269883 |
Myelocyte count increased | 12.14 | 9.85 | 13 | 319872 | 340 | 50284899 |
Hypomagnesaemia | 12.13 | 9.85 | 91 | 319794 | 23065 | 50262174 |
Multiple-drug resistance | 12.12 | 9.85 | 3 | 319882 | 3311 | 50281928 |
Dysarthria | 12.09 | 9.85 | 165 | 319720 | 37238 | 50248001 |
Mitral valve incompetence | 12.08 | 9.85 | 63 | 319822 | 17408 | 50267831 |
Amenorrhoea | 12.03 | 9.85 | 22 | 319863 | 8462 | 50276777 |
Deep vein thrombosis | 12.02 | 9.85 | 362 | 319523 | 72942 | 50212297 |
Delusion | 12.01 | 9.85 | 31 | 319854 | 10538 | 50274701 |
Premature delivery | 11.92 | 9.85 | 94 | 319791 | 23569 | 50261670 |
Status epilepticus | 11.91 | 9.85 | 44 | 319841 | 13362 | 50271877 |
Haematuria | 11.88 | 9.85 | 104 | 319781 | 25509 | 50259730 |
Precancerous cells present | 11.88 | 9.85 | 25 | 319860 | 1212 | 50284027 |
Drug level below therapeutic | 11.85 | 9.85 | 51 | 319834 | 3689 | 50281550 |
Swelling face | 11.79 | 9.85 | 248 | 319637 | 52347 | 50232892 |
Drug eruption | 11.78 | 9.85 | 94 | 319791 | 23512 | 50261727 |
Urine ketone body present | 11.78 | 9.85 | 37 | 319848 | 2296 | 50282943 |
Skin lesion | 11.75 | 9.85 | 110 | 319775 | 26617 | 50258622 |
Base excess | 11.74 | 9.85 | 7 | 319878 | 75 | 50285164 |
Flushing | 11.72 | 9.85 | 527 | 319358 | 66488 | 50218751 |
Aplasia pure red cell | 11.70 | 9.85 | 6 | 319879 | 4209 | 50281030 |
Neonatal respiratory acidosis | 11.64 | 9.85 | 9 | 319876 | 152 | 50285087 |
Caesarean section | 11.61 | 9.85 | 55 | 319830 | 15584 | 50269655 |
Cardiac failure chronic | 11.61 | 9.85 | 4 | 319881 | 3559 | 50281680 |
Diaphragmatic rupture | 11.59 | 9.85 | 11 | 319874 | 248 | 50284991 |
Priapism | 11.58 | 9.85 | 7 | 319878 | 77 | 50285162 |
Dysphoria | 11.56 | 9.85 | 8 | 319877 | 4766 | 50280473 |
Electrocardiogram QT prolonged | 11.53 | 9.85 | 245 | 319640 | 51641 | 50233598 |
Hepatitis acute | 11.51 | 9.85 | 88 | 319797 | 7873 | 50277366 |
Nervous system disorder | 11.50 | 9.85 | 58 | 319827 | 16165 | 50269074 |
Ocular hyperaemia | 11.47 | 9.85 | 78 | 319807 | 20214 | 50265025 |
Pelvic fracture | 11.46 | 9.85 | 36 | 319849 | 11484 | 50273755 |
Eructation | 11.46 | 9.85 | 17 | 319868 | 7104 | 50278135 |
Breast cancer female | 11.42 | 9.85 | 16 | 319869 | 6846 | 50278393 |
Diplopia | 11.41 | 9.85 | 73 | 319812 | 19187 | 50266052 |
Erysipelas | 11.41 | 9.85 | 15 | 319870 | 6593 | 50278646 |
Intestinal haemorrhage | 11.40 | 9.85 | 3 | 319882 | 3177 | 50282062 |
Gastrointestinal pain | 11.32 | 9.85 | 21 | 319864 | 8035 | 50277204 |
Administration site reaction | 11.28 | 9.85 | 10 | 319875 | 206 | 50285033 |
Device deployment issue | 11.26 | 9.85 | 4 | 319881 | 3492 | 50281747 |
Neutrophil count decreased | 11.22 | 9.85 | 214 | 319671 | 45812 | 50239427 |
Vital capacity decreased | 11.20 | 9.85 | 21 | 319864 | 935 | 50284304 |
Drug tolerance | 11.19 | 9.85 | 9 | 319876 | 4967 | 50280272 |
Complication of device insertion | 11.18 | 9.85 | 13 | 319872 | 6028 | 50279211 |
Cardiotoxicity | 11.09 | 9.85 | 17 | 319868 | 7010 | 50278229 |
Band neutrophil percentage increased | 11.08 | 9.85 | 10 | 319875 | 211 | 50285028 |
Autonomic dysreflexia | 11.05 | 9.85 | 12 | 319873 | 319 | 50284920 |
Gastroenteritis | 11.03 | 9.85 | 94 | 319791 | 23187 | 50262052 |
Pulmonary mass | 11.03 | 9.85 | 71 | 319814 | 18634 | 50266605 |
Product preparation error | 11.02 | 9.85 | 7 | 319878 | 4365 | 50280874 |
Therapy non-responder | 11.02 | 9.85 | 242 | 319643 | 50780 | 50234459 |
Urinary casts | 11.00 | 9.85 | 17 | 319868 | 646 | 50284593 |
Epstein-Barr virus infection | 10.98 | 9.85 | 17 | 319868 | 6980 | 50278259 |
Labelled drug-drug interaction medication error | 10.95 | 9.85 | 32 | 319853 | 10445 | 50274794 |
Device related thrombosis | 10.94 | 9.85 | 25 | 319860 | 1282 | 50283957 |
Mania | 10.94 | 9.85 | 34 | 319851 | 10882 | 50274357 |
Head injury | 10.93 | 9.85 | 98 | 319787 | 23922 | 50261317 |
Neuroleptic malignant syndrome | 10.92 | 9.85 | 35 | 319850 | 11095 | 50274144 |
Frequent bowel movements | 10.90 | 9.85 | 48 | 319837 | 13870 | 50271369 |
Traumatic liver injury | 10.87 | 9.85 | 11 | 319874 | 269 | 50284970 |
Chronic obstructive pulmonary disease | 10.82 | 9.85 | 256 | 319629 | 53179 | 50232060 |
Continuous haemodiafiltration | 10.80 | 9.85 | 21 | 319864 | 961 | 50284278 |
Transaminases increased | 10.80 | 9.85 | 241 | 319644 | 27583 | 50257656 |
Tooth extraction | 10.79 | 9.85 | 26 | 319859 | 9049 | 50276190 |
Infective pulmonary exacerbation of cystic fibrosis | 10.78 | 9.85 | 21 | 319864 | 7888 | 50277351 |
Metastases to central nervous system | 10.71 | 9.85 | 36 | 319849 | 11246 | 50273993 |
Mean cell haemoglobin concentration decreased | 10.66 | 9.85 | 41 | 319844 | 2818 | 50282421 |
Acute myeloid leukaemia | 10.62 | 9.85 | 54 | 319831 | 15020 | 50270219 |
Drug level increased | 10.59 | 9.85 | 176 | 319709 | 19092 | 50266147 |
Nightmare | 10.57 | 9.85 | 59 | 319826 | 16027 | 50269212 |
Rheumatoid nodule | 10.54 | 9.85 | 43 | 319842 | 12692 | 50272547 |
Corneal reflex decreased | 10.50 | 9.85 | 8 | 319877 | 132 | 50285107 |
Urine oxalate increased | 10.48 | 9.85 | 10 | 319875 | 227 | 50285012 |
Maternal exposure timing unspecified | 10.44 | 9.85 | 48 | 319837 | 3572 | 50281667 |
Ear infection | 10.42 | 9.85 | 226 | 319659 | 25744 | 50259495 |
Upper respiratory tract infection | 10.41 | 9.85 | 513 | 319372 | 65385 | 50219854 |
Maternal exposure before pregnancy | 10.41 | 9.85 | 12 | 319873 | 5585 | 50279654 |
Pleural effusion | 10.40 | 9.85 | 415 | 319470 | 81039 | 50204200 |
Hemiparesis | 10.40 | 9.85 | 79 | 319806 | 19969 | 50265270 |
Allergy to plants | 10.39 | 9.85 | 16 | 319869 | 606 | 50284633 |
Infusion site discolouration | 10.39 | 9.85 | 16 | 319869 | 606 | 50284633 |
Bacterial test positive | 10.37 | 9.85 | 58 | 319827 | 4665 | 50280574 |
Impaired gastric emptying | 10.35 | 9.85 | 25 | 319860 | 8693 | 50276546 |
Brain stem glioma | 10.35 | 9.85 | 8 | 319877 | 135 | 50285104 |
Injection site extravasation | 10.34 | 9.85 | 82 | 319803 | 7419 | 50277820 |
Left ventricular dysfunction | 10.33 | 9.85 | 33 | 319852 | 10473 | 50274766 |
Congestive hepatopathy | 10.33 | 9.85 | 37 | 319848 | 2457 | 50282782 |
Asthenia | 10.30 | 9.85 | 1817 | 318068 | 317225 | 49968014 |
Excessive skin | 10.25 | 9.85 | 8 | 319877 | 137 | 50285102 |
Infusion site reaction | 10.25 | 9.85 | 34 | 319851 | 2172 | 50283067 |
Carbon monoxide poisoning | 10.25 | 9.85 | 9 | 319876 | 183 | 50285056 |
Skin toxicity | 10.24 | 9.85 | 6 | 319879 | 3907 | 50281332 |
Post-traumatic stress disorder | 10.23 | 9.85 | 54 | 319831 | 4249 | 50280990 |
Monocyte count increased | 10.23 | 9.85 | 65 | 319820 | 5474 | 50279765 |
Femoral neck fracture | 10.11 | 9.85 | 20 | 319865 | 7470 | 50277769 |
Encephalopathy | 10.11 | 9.85 | 282 | 319603 | 33429 | 50251810 |
Congestive cardiomyopathy | 10.08 | 9.85 | 12 | 319873 | 5506 | 50279733 |
Pharyngeal paraesthesia | 10.06 | 9.85 | 26 | 319859 | 1443 | 50283796 |
Magnesium deficiency | 10.00 | 9.85 | 14 | 319871 | 486 | 50284753 |
Endophthalmitis | 9.99 | 9.85 | 3 | 319882 | 2913 | 50282326 |
Osmolar gap abnormal | 9.94 | 9.85 | 5 | 319880 | 37 | 50285202 |
Haemarthrosis | 9.94 | 9.85 | 3 | 319882 | 2905 | 50282334 |
Therapy change | 9.94 | 9.85 | 11 | 319874 | 5214 | 50280025 |
Muscular weakness | 9.90 | 9.85 | 495 | 319390 | 94518 | 50190721 |
Death | 9.88 | 9.85 | 2261 | 317624 | 323118 | 49962121 |
Unintended pregnancy | 9.87 | 9.85 | 10 | 319875 | 4936 | 50280303 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1300.55 | 10.15 | 1794 | 129780 | 88452 | 29354501 |
Toxicity to various agents | 1089.36 | 10.15 | 2388 | 129186 | 171273 | 29271680 |
Infusion related reaction | 449.05 | 10.15 | 745 | 130829 | 43141 | 29399812 |
Blood pressure fluctuation | 354.61 | 10.15 | 440 | 131134 | 19454 | 29423499 |
Exposure to toxic agent | 321.87 | 10.15 | 178 | 131396 | 2397 | 29440556 |
Overdose | 298.84 | 10.15 | 906 | 130668 | 78913 | 29364040 |
Acute hepatic failure | 269.02 | 10.15 | 298 | 131276 | 11654 | 29431299 |
Intentional product misuse | 232.30 | 10.15 | 491 | 131083 | 34170 | 29408783 |
Drug ineffective | 206.17 | 10.15 | 875 | 130699 | 362295 | 29080658 |
Intentional overdose | 165.83 | 10.15 | 460 | 131114 | 38068 | 29404885 |
Heart rate decreased | 153.28 | 10.15 | 341 | 131233 | 24571 | 29418382 |
Blood pressure increased | 124.70 | 10.15 | 653 | 130921 | 73150 | 29369803 |
Metabolic acidosis | 112.36 | 10.15 | 396 | 131178 | 37266 | 29405687 |
Hepatic cytolysis | 99.40 | 10.15 | 152 | 131422 | 8195 | 29434758 |
Oxygen saturation decreased | 97.91 | 10.15 | 428 | 131146 | 44509 | 29398444 |
Product dose omission issue | 90.20 | 10.15 | 183 | 131391 | 96200 | 29346753 |
Myocardial infarction | 89.75 | 10.15 | 226 | 131348 | 110070 | 29332883 |
Hepatotoxicity | 88.68 | 10.15 | 225 | 131349 | 17642 | 29425311 |
Coagulopathy | 88.35 | 10.15 | 225 | 131349 | 17682 | 29425271 |
Anion gap | 86.86 | 10.15 | 49 | 131525 | 687 | 29442266 |
Respiratory arrest | 79.95 | 10.15 | 275 | 131299 | 25558 | 29417395 |
Cardio-respiratory arrest | 76.83 | 10.15 | 435 | 131139 | 50166 | 29392787 |
Intentional product use issue | 70.32 | 10.15 | 374 | 131200 | 42124 | 29400829 |
Respiratory depression | 68.89 | 10.15 | 172 | 131402 | 13351 | 29429602 |
Hepatic necrosis | 67.38 | 10.15 | 81 | 131493 | 3461 | 29439492 |
Accidental overdose | 66.90 | 10.15 | 201 | 131373 | 17392 | 29425561 |
Suspected suicide | 65.39 | 10.15 | 85 | 131489 | 3935 | 29439018 |
Cardiac failure congestive | 64.55 | 10.15 | 154 | 131420 | 76427 | 29366526 |
Sinusitis | 64.32 | 10.15 | 313 | 131261 | 34037 | 29408916 |
Diarrhoea | 63.92 | 10.15 | 1069 | 130505 | 331629 | 29111324 |
Substance abuse | 63.73 | 10.15 | 111 | 131463 | 6676 | 29436277 |
Heart rate irregular | 62.83 | 10.15 | 163 | 131411 | 12954 | 29429999 |
Blood pressure systolic increased | 61.75 | 10.15 | 190 | 131384 | 16655 | 29426298 |
Drug resistance | 61.05 | 10.15 | 11 | 131563 | 21529 | 29421424 |
Hypotension | 60.04 | 10.15 | 1205 | 130369 | 193149 | 29249804 |
Alanine aminotransferase increased | 59.48 | 10.15 | 528 | 131046 | 70416 | 29372537 |
Chills | 58.93 | 10.15 | 529 | 131045 | 70771 | 29372182 |
Blood pressure diastolic abnormal | 58.06 | 10.15 | 64 | 131510 | 2487 | 29440466 |
Liver injury | 57.03 | 10.15 | 154 | 131420 | 12536 | 29430417 |
Treatment failure | 52.55 | 10.15 | 52 | 131522 | 36887 | 29406066 |
Poisoning | 50.79 | 10.15 | 127 | 131447 | 9866 | 29433087 |
Aspartate aminotransferase increased | 48.76 | 10.15 | 442 | 131132 | 59283 | 29383670 |
Drug abuse | 48.38 | 10.15 | 556 | 131018 | 79327 | 29363626 |
Heart rate increased | 44.29 | 10.15 | 311 | 131263 | 38627 | 29404326 |
Medication error | 43.89 | 10.15 | 199 | 131375 | 21012 | 29421941 |
Analgesic drug level increased | 43.20 | 10.15 | 29 | 131545 | 563 | 29442390 |
Toxic epidermal necrolysis | 42.68 | 10.15 | 177 | 131397 | 17976 | 29424977 |
Blood pressure diastolic increased | 42.31 | 10.15 | 66 | 131508 | 3620 | 29439333 |
Exposure via ingestion | 41.45 | 10.15 | 48 | 131526 | 1970 | 29440983 |
Infusion site extravasation | 40.16 | 10.15 | 59 | 131515 | 3068 | 29439885 |
Body temperature decreased | 39.75 | 10.15 | 121 | 131453 | 10543 | 29432410 |
Blood pressure systolic abnormal | 38.80 | 10.15 | 48 | 131526 | 2113 | 29440840 |
Cardiac failure | 38.78 | 10.15 | 201 | 131373 | 79086 | 29363867 |
Infusion site pain | 37.30 | 10.15 | 55 | 131519 | 2870 | 29440083 |
Therapeutic response shortened | 36.97 | 10.15 | 72 | 131502 | 4719 | 29438234 |
Pyroglutamic acidosis | 36.84 | 10.15 | 20 | 131554 | 259 | 29442694 |
Blood pressure diastolic decreased | 36.48 | 10.15 | 90 | 131484 | 6932 | 29436021 |
Rheumatoid arthritis | 36.09 | 10.15 | 256 | 131318 | 31896 | 29411057 |
Cytokine release syndrome | 35.76 | 10.15 | 134 | 131440 | 12985 | 29429968 |
Coronary artery disease | 35.54 | 10.15 | 91 | 131483 | 44099 | 29398854 |
Depressed level of consciousness | 35.20 | 10.15 | 283 | 131291 | 36659 | 29406294 |
International normalised ratio increased | 34.50 | 10.15 | 325 | 131249 | 44047 | 29398906 |
Stevens-Johnson syndrome | 33.55 | 10.15 | 154 | 131420 | 16343 | 29426610 |
Renal cortical necrosis | 33.41 | 10.15 | 16 | 131558 | 156 | 29442797 |
Appendicolith | 32.78 | 10.15 | 57 | 131517 | 3423 | 29439530 |
Neutrophil percentage increased | 32.69 | 10.15 | 40 | 131534 | 1741 | 29441212 |
Neuropathy peripheral | 32.56 | 10.15 | 184 | 131390 | 70843 | 29372110 |
Drug interaction | 32.20 | 10.15 | 652 | 130922 | 196733 | 29246220 |
Therapeutic product effect incomplete | 31.56 | 10.15 | 81 | 131493 | 39224 | 29403729 |
Coma | 31.19 | 10.15 | 290 | 131284 | 39160 | 29403793 |
Infusion site swelling | 31.14 | 10.15 | 40 | 131534 | 1830 | 29441123 |
Psoriasis | 31.13 | 10.15 | 60 | 131514 | 32167 | 29410786 |
Dizziness | 31.10 | 10.15 | 626 | 130948 | 189058 | 29253895 |
Anaemia | 30.95 | 10.15 | 670 | 130904 | 200281 | 29242672 |
Hepatic failure | 30.89 | 10.15 | 243 | 131331 | 31269 | 29411684 |
Blood pH decreased | 29.97 | 10.15 | 42 | 131532 | 2091 | 29440862 |
Wrong technique in product usage process | 29.94 | 10.15 | 59 | 131515 | 31369 | 29411584 |
Body temperature increased | 29.39 | 10.15 | 135 | 131439 | 14330 | 29428623 |
Tachycardia | 29.38 | 10.15 | 469 | 131105 | 71941 | 29371012 |
Abdominal pain | 29.00 | 10.15 | 798 | 130776 | 134559 | 29308394 |
Pyrexia | 28.60 | 10.15 | 1558 | 130016 | 286064 | 29156889 |
Methaemoglobinaemia | 28.15 | 10.15 | 46 | 131528 | 2625 | 29440328 |
Product use in unapproved indication | 28.09 | 10.15 | 249 | 131325 | 86626 | 29356327 |
Depression | 28.00 | 10.15 | 243 | 131331 | 84904 | 29358049 |
Suicide attempt | 27.09 | 10.15 | 251 | 131323 | 33859 | 29409094 |
Contraindicated product administered | 26.81 | 10.15 | 25 | 131549 | 18241 | 29424712 |
Myocardial fibrosis | 26.42 | 10.15 | 28 | 131546 | 1040 | 29441913 |
Sopor | 26.21 | 10.15 | 8 | 131566 | 10926 | 29432027 |
Lymphocyte percentage decreased | 25.82 | 10.15 | 38 | 131536 | 1979 | 29440974 |
Memory impairment | 25.71 | 10.15 | 80 | 131494 | 36390 | 29406563 |
Product prescribing error | 24.77 | 10.15 | 26 | 131548 | 17950 | 29425003 |
Urine sodium decreased | 24.45 | 10.15 | 13 | 131561 | 161 | 29442792 |
Injection site pain | 24.44 | 10.15 | 69 | 131505 | 32377 | 29410576 |
Body temperature fluctuation | 24.12 | 10.15 | 31 | 131543 | 1419 | 29441534 |
Prothrombin time prolonged | 23.89 | 10.15 | 90 | 131484 | 8742 | 29434211 |
Poor venous access | 23.78 | 10.15 | 47 | 131527 | 3114 | 29439839 |
Respiratory rate increased | 23.78 | 10.15 | 89 | 131485 | 8619 | 29434334 |
Ductus arteriosus premature closure | 23.71 | 10.15 | 14 | 131560 | 215 | 29442738 |
Hospitalisation | 23.37 | 10.15 | 115 | 131459 | 45873 | 29397080 |
Asthenia | 23.29 | 10.15 | 755 | 130819 | 214495 | 29228458 |
Aplastic anaemia | 23.27 | 10.15 | 80 | 131494 | 7430 | 29435523 |
Bone marrow failure | 23.26 | 10.15 | 55 | 131519 | 27394 | 29415559 |
Unresponsive to stimuli | 23.13 | 10.15 | 191 | 131383 | 24935 | 29418018 |
Acute lung injury | 22.96 | 10.15 | 29 | 131545 | 1304 | 29441649 |
Febrile neutropenia | 22.71 | 10.15 | 657 | 130917 | 111583 | 29331370 |
Glycosylated haemoglobin increased | 22.41 | 10.15 | 7 | 131567 | 9419 | 29433534 |
Feeling abnormal | 22.34 | 10.15 | 146 | 131428 | 54299 | 29388654 |
Ear infection | 22.29 | 10.15 | 83 | 131491 | 8017 | 29434936 |
Cardiac arrest | 22.27 | 10.15 | 518 | 131056 | 85073 | 29357880 |
Urticaria | 21.78 | 10.15 | 353 | 131221 | 54307 | 29388646 |
Cerebrovascular accident | 21.66 | 10.15 | 228 | 131346 | 76683 | 29366270 |
Infusion site pruritus | 21.21 | 10.15 | 18 | 131556 | 503 | 29442450 |
Cerebral artery thrombosis | 21.16 | 10.15 | 21 | 131553 | 721 | 29442232 |
Inappropriate schedule of product administration | 21.13 | 10.15 | 296 | 131278 | 44176 | 29398777 |
Granulomatosis with polyangiitis | 21.09 | 10.15 | 23 | 131551 | 883 | 29442070 |
Visual acuity reduced | 21.08 | 10.15 | 21 | 131553 | 14855 | 29428098 |
Disease progression | 21.03 | 10.15 | 248 | 131326 | 81668 | 29361285 |
Nasopharyngitis | 20.76 | 10.15 | 377 | 131197 | 59288 | 29383665 |
Transaminases increased | 20.71 | 10.15 | 172 | 131402 | 22490 | 29420463 |
Haemolysis | 20.60 | 10.15 | 73 | 131501 | 6883 | 29436070 |
Renal impairment | 20.58 | 10.15 | 247 | 131327 | 81086 | 29361867 |
Fatigue | 20.54 | 10.15 | 1177 | 130397 | 315644 | 29127309 |
Brain scan abnormal | 20.52 | 10.15 | 22 | 131552 | 828 | 29442125 |
Balance disorder | 19.82 | 10.15 | 88 | 131486 | 36082 | 29406871 |
Progressive multifocal leukoencephalopathy | 19.81 | 10.15 | 7 | 131567 | 8712 | 29434241 |
Malignant neoplasm progression | 19.58 | 10.15 | 222 | 131352 | 73637 | 29369316 |
Acidosis | 19.29 | 10.15 | 90 | 131484 | 9615 | 29433338 |
Pulmonary oedema | 18.94 | 10.15 | 281 | 131293 | 42454 | 29400499 |
Chronic gastrointestinal bleeding | 18.53 | 10.15 | 13 | 131561 | 272 | 29442681 |
Dyspnoea | 18.52 | 10.15 | 1229 | 130345 | 325503 | 29117450 |
Interstitial lung disease | 18.40 | 10.15 | 166 | 131408 | 57552 | 29385401 |
Diabetes mellitus | 18.34 | 10.15 | 103 | 131471 | 39728 | 29403225 |
Cerebral haemorrhage | 18.12 | 10.15 | 75 | 131499 | 31351 | 29411602 |
Anion gap abnormal | 17.93 | 10.15 | 10 | 131564 | 137 | 29442816 |
Pemphigus | 17.92 | 10.15 | 24 | 131550 | 1144 | 29441809 |
Oxygen saturation abnormal | 17.54 | 10.15 | 24 | 131550 | 1168 | 29441785 |
Brain death | 17.54 | 10.15 | 35 | 131539 | 2335 | 29440618 |
Osteonecrosis of jaw | 17.51 | 10.15 | 29 | 131545 | 16481 | 29426472 |
Throat tightness | 17.34 | 10.15 | 70 | 131504 | 7021 | 29435932 |
Full blood count abnormal | 17.23 | 10.15 | 25 | 131549 | 14988 | 29427965 |
Flushing | 17.17 | 10.15 | 201 | 131373 | 28791 | 29414162 |
Renal papillary necrosis | 17.08 | 10.15 | 10 | 131564 | 151 | 29442802 |
Victim of chemical submission | 16.85 | 10.15 | 7 | 131567 | 47 | 29442906 |
Cerebral infarction | 16.78 | 10.15 | 55 | 131519 | 24620 | 29418333 |
Oedema peripheral | 16.57 | 10.15 | 343 | 131231 | 103214 | 29339739 |
Immune reconstitution inflammatory syndrome | 16.51 | 10.15 | 7 | 131567 | 7795 | 29435158 |
Decreased appetite | 16.37 | 10.15 | 507 | 131067 | 144835 | 29298118 |
Urethral valves | 16.31 | 10.15 | 12 | 131562 | 271 | 29442682 |
Therapeutic response decreased | 16.17 | 10.15 | 56 | 131518 | 24655 | 29418298 |
Blood triglycerides increased | 16.12 | 10.15 | 20 | 131554 | 12814 | 29430139 |
Acute myocardial infarction | 16.01 | 10.15 | 138 | 131436 | 48300 | 29394653 |
Haematotoxicity | 15.88 | 10.15 | 5 | 131569 | 6694 | 29436259 |
Dependent personality disorder | 15.79 | 10.15 | 8 | 131566 | 89 | 29442864 |
Administration site pain | 15.60 | 10.15 | 10 | 131564 | 179 | 29442774 |
Graft versus host disease | 15.57 | 10.15 | 12 | 131562 | 9616 | 29433337 |
Infusion site erythema | 15.34 | 10.15 | 27 | 131547 | 1637 | 29441316 |
Therapeutic product effect decreased | 15.34 | 10.15 | 73 | 131501 | 29378 | 29413575 |
Visual impairment | 15.26 | 10.15 | 74 | 131500 | 29634 | 29413319 |
Drug ineffective for unapproved indication | 15.04 | 10.15 | 25 | 131549 | 14189 | 29428764 |
Appendicitis | 15.01 | 10.15 | 78 | 131496 | 8701 | 29434252 |
Mucosal inflammation | 14.93 | 10.15 | 81 | 131493 | 31514 | 29411439 |
Failure to suspend medication | 14.86 | 10.15 | 13 | 131561 | 379 | 29442574 |
Myopathy | 14.78 | 10.15 | 15 | 131559 | 10518 | 29432435 |
Bilirubin urine present | 14.76 | 10.15 | 9 | 131565 | 147 | 29442806 |
Environmental exposure | 14.67 | 10.15 | 11 | 131563 | 256 | 29442697 |
Angina pectoris | 14.52 | 10.15 | 69 | 131505 | 27781 | 29415172 |
Psoriatic arthropathy | 14.50 | 10.15 | 27 | 131547 | 14664 | 29428289 |
Fluid retention | 14.36 | 10.15 | 55 | 131519 | 23505 | 29419448 |
Foetal exposure during pregnancy | 14.31 | 10.15 | 90 | 131484 | 33777 | 29409176 |
Throat irritation | 14.30 | 10.15 | 77 | 131497 | 8708 | 29434245 |
Administration site erythema | 14.29 | 10.15 | 7 | 131567 | 72 | 29442881 |
Pallor | 13.92 | 10.15 | 149 | 131425 | 20875 | 29422078 |
Cardiac disorder | 13.77 | 10.15 | 103 | 131471 | 37160 | 29405793 |
Inadequate analgesia | 13.77 | 10.15 | 34 | 131540 | 2620 | 29440333 |
Asthma | 13.77 | 10.15 | 91 | 131483 | 33758 | 29409195 |
Drug level below therapeutic | 13.67 | 10.15 | 46 | 131528 | 4225 | 29438728 |
Anti-erythrocyte antibody positive | 13.66 | 10.15 | 6 | 131568 | 47 | 29442906 |
Infusion site rash | 13.65 | 10.15 | 12 | 131562 | 352 | 29442601 |
Hypoxia | 13.65 | 10.15 | 291 | 131283 | 47088 | 29395865 |
Lung neoplasm malignant | 13.63 | 10.15 | 27 | 131547 | 14330 | 29428623 |
Myelosuppression | 13.41 | 10.15 | 21 | 131553 | 12206 | 29430747 |
Venoocclusive liver disease | 13.41 | 10.15 | 7 | 131567 | 6910 | 29436043 |
Pulmonary congestion | 13.36 | 10.15 | 98 | 131476 | 12338 | 29430615 |
Infusion site nodule | 13.36 | 10.15 | 7 | 131567 | 84 | 29442869 |
Product quality issue | 13.35 | 10.15 | 32 | 131542 | 15863 | 29427090 |
Post transplant lymphoproliferative disorder | 13.20 | 10.15 | 4 | 131570 | 5489 | 29437464 |
Infusion site bruising | 12.97 | 10.15 | 12 | 131562 | 377 | 29442576 |
Infusion site haemorrhage | 12.94 | 10.15 | 16 | 131558 | 704 | 29442249 |
COVID-19 immunisation | 12.84 | 10.15 | 8 | 131566 | 136 | 29442817 |
Hepatitis fulminant | 12.82 | 10.15 | 40 | 131534 | 3531 | 29439422 |
Loss of personal independence in daily activities | 12.70 | 10.15 | 64 | 131510 | 25376 | 29417577 |
Acid-base balance disorder mixed | 12.66 | 10.15 | 6 | 131568 | 57 | 29442896 |
Prescribed overdose | 12.60 | 10.15 | 12 | 131562 | 8671 | 29434282 |
No adverse event | 12.56 | 10.15 | 38 | 131536 | 17440 | 29425513 |
Injection site swelling | 12.55 | 10.15 | 14 | 131560 | 9403 | 29433550 |
Hyperlipidaemia | 12.54 | 10.15 | 23 | 131551 | 12567 | 29430386 |
Anion gap increased | 12.50 | 10.15 | 24 | 131550 | 1556 | 29441397 |
Endocardial fibrosis | 12.50 | 10.15 | 5 | 131569 | 30 | 29442923 |
Insomnia | 12.48 | 10.15 | 300 | 131274 | 88461 | 29354492 |
Prostatic specific antigen increased | 12.48 | 10.15 | 23 | 131551 | 12541 | 29430412 |
Liver transplant | 12.37 | 10.15 | 30 | 131544 | 2286 | 29440667 |
Labelled drug-drug interaction medication error | 12.31 | 10.15 | 22 | 131552 | 12137 | 29430816 |
Tooth infection | 12.23 | 10.15 | 53 | 131521 | 5486 | 29437467 |
Electrocardiogram QRS complex prolonged | 12.06 | 10.15 | 43 | 131531 | 4067 | 29438886 |
Pathogen resistance | 12.04 | 10.15 | 11 | 131563 | 8105 | 29434848 |
Crystal urine present | 11.97 | 10.15 | 12 | 131562 | 417 | 29442536 |
Adverse event | 11.90 | 10.15 | 32 | 131542 | 15259 | 29427694 |
Bacterial test | 11.89 | 10.15 | 8 | 131566 | 156 | 29442797 |
Cardiac failure chronic | 11.88 | 10.15 | 7 | 131567 | 6460 | 29436493 |
Parkinsonism | 11.86 | 10.15 | 9 | 131565 | 7269 | 29435684 |
Haematocrit decreased | 11.77 | 10.15 | 188 | 131386 | 28834 | 29414119 |
Gait disturbance | 11.71 | 10.15 | 243 | 131331 | 73106 | 29369847 |
Injection site haemorrhage | 11.70 | 10.15 | 12 | 131562 | 8374 | 29434579 |
Ammonia increased | 11.68 | 10.15 | 42 | 131532 | 3989 | 29438964 |
Protein urine | 11.58 | 10.15 | 16 | 131558 | 786 | 29442167 |
Tendonitis | 11.56 | 10.15 | 11 | 131563 | 7950 | 29435003 |
Injection site reaction | 11.54 | 10.15 | 20 | 131554 | 11168 | 29431785 |
Osteonecrosis | 11.52 | 10.15 | 27 | 131547 | 13492 | 29429461 |
Vomiting | 11.52 | 10.15 | 1095 | 130479 | 211165 | 29231788 |
Urobilinogen urine increased | 11.49 | 10.15 | 11 | 131563 | 361 | 29442592 |
Bladder cancer | 11.49 | 10.15 | 17 | 131557 | 10110 | 29432843 |
Monocyte percentage increased | 11.40 | 10.15 | 17 | 131557 | 896 | 29442057 |
Urine abnormality | 11.34 | 10.15 | 24 | 131550 | 1670 | 29441283 |
Leukopenia | 11.31 | 10.15 | 175 | 131399 | 55028 | 29387925 |
Brain oedema | 11.30 | 10.15 | 93 | 131481 | 12127 | 29430826 |
Pharyngeal paraesthesia | 11.27 | 10.15 | 12 | 131562 | 448 | 29442505 |
Sleep disorder | 11.26 | 10.15 | 63 | 131511 | 24323 | 29418630 |
Cytomegalovirus infection | 11.25 | 10.15 | 59 | 131515 | 23156 | 29419797 |
Injection site pruritus | 11.22 | 10.15 | 6 | 131568 | 5843 | 29437110 |
Prostate cancer | 11.22 | 10.15 | 67 | 131507 | 25460 | 29417493 |
Victim of sexual abuse | 11.19 | 10.15 | 3 | 131571 | 3 | 29442950 |
Bronchial dysplasia | 11.18 | 10.15 | 5 | 131569 | 41 | 29442912 |
Gait inability | 11.13 | 10.15 | 43 | 131531 | 18332 | 29424621 |
Ultrasound liver abnormal | 11.08 | 10.15 | 7 | 131567 | 122 | 29442831 |
Crohn's disease | 11.08 | 10.15 | 34 | 131540 | 2975 | 29439978 |
Mydriasis | 11.06 | 10.15 | 55 | 131519 | 6030 | 29436923 |
Erectile dysfunction | 11 | 10.15 | 42 | 131532 | 17967 | 29424986 |
Vessel puncture site bruise | 10.98 | 10.15 | 5 | 131569 | 43 | 29442910 |
Areflexia | 10.98 | 10.15 | 32 | 131542 | 2722 | 29440231 |
General physical health deterioration | 10.80 | 10.15 | 362 | 131212 | 102495 | 29340458 |
C-reactive protein abnormal | 10.76 | 10.15 | 8 | 131566 | 6528 | 29436425 |
Cytopenia | 10.75 | 10.15 | 17 | 131557 | 9842 | 29433111 |
Enterocolitis infectious | 10.72 | 10.15 | 20 | 131554 | 1269 | 29441684 |
Analgesic drug level above therapeutic | 10.68 | 10.15 | 9 | 131565 | 249 | 29442704 |
Respiratory distress | 10.51 | 10.15 | 201 | 131373 | 31905 | 29411048 |
Chronic obstructive pulmonary disease | 10.50 | 10.15 | 124 | 131450 | 40831 | 29402122 |
Pyroglutamate increased | 10.47 | 10.15 | 9 | 131565 | 256 | 29442697 |
Hypoaesthesia | 10.45 | 10.15 | 171 | 131403 | 53296 | 29389657 |
Fall | 10.41 | 10.15 | 664 | 130910 | 176514 | 29266439 |
Specific gravity urine decreased | 10.28 | 10.15 | 6 | 131568 | 90 | 29442863 |
Mental status changes | 10.22 | 10.15 | 215 | 131359 | 34712 | 29408241 |
Urine analysis abnormal | 10.18 | 10.15 | 24 | 131550 | 1796 | 29441157 |
Akathisia | 10.16 | 10.15 | 9 | 131565 | 6733 | 29436220 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 4089.41 | 9.76 | 5685 | 362889 | 218729 | 63911429 |
Toxicity to various agents | 3051.26 | 9.76 | 6528 | 362046 | 356985 | 63773173 |
Infusion related reaction | 1129.63 | 9.76 | 2734 | 365840 | 161733 | 63968425 |
Exposure to toxic agent | 846.44 | 9.76 | 494 | 368080 | 5665 | 64124493 |
Acute hepatic failure | 744.15 | 9.76 | 830 | 367744 | 25282 | 64104876 |
Blood pressure fluctuation | 702.46 | 9.76 | 1147 | 367427 | 50724 | 64079434 |
Overdose | 676.70 | 9.76 | 2228 | 366346 | 157338 | 63972820 |
Intentional product misuse | 670.00 | 9.76 | 1356 | 367218 | 70939 | 64059219 |
Intentional overdose | 405.44 | 9.76 | 1283 | 367291 | 88661 | 64041497 |
Metabolic acidosis | 387.06 | 9.76 | 1083 | 367491 | 69875 | 64060283 |
Rheumatoid arthritis | 386.62 | 9.76 | 1910 | 366664 | 162384 | 63967774 |
Product dose omission issue | 315.70 | 9.76 | 389 | 368185 | 194358 | 63935800 |
Hepatotoxicity | 304.96 | 9.76 | 693 | 367881 | 39269 | 64090889 |
Muscle injury | 301.69 | 9.76 | 542 | 368032 | 25895 | 64104263 |
Heart rate decreased | 295.89 | 9.76 | 836 | 367738 | 54231 | 64075927 |
Sinusitis | 294.54 | 9.76 | 1626 | 366948 | 144302 | 63985856 |
Folliculitis | 278.28 | 9.76 | 564 | 368010 | 29513 | 64100645 |
Anti-cyclic citrullinated peptide antibody positive | 277.69 | 9.76 | 764 | 367810 | 48798 | 64081360 |
Duodenal ulcer perforation | 271.51 | 9.76 | 607 | 367967 | 34018 | 64096140 |
Anion gap | 270.49 | 9.76 | 155 | 368419 | 1712 | 64128446 |
Sleep disorder due to general medical condition, insomnia type | 262.80 | 9.76 | 509 | 368065 | 25761 | 64104397 |
Irritable bowel syndrome | 261.05 | 9.76 | 626 | 367948 | 36743 | 64093415 |
Helicobacter infection | 255.57 | 9.76 | 631 | 367943 | 37731 | 64092427 |
Hepatic enzyme increased | 245.09 | 9.76 | 1422 | 367152 | 128521 | 64001637 |
Blood pressure increased | 239.62 | 9.76 | 1748 | 366826 | 170804 | 63959354 |
Injection site pain | 225.77 | 9.76 | 183 | 368391 | 111225 | 64018933 |
Lower respiratory tract infection | 224.52 | 9.76 | 1103 | 367471 | 93511 | 64036647 |
Hand deformity | 224.48 | 9.76 | 829 | 367745 | 61942 | 64068216 |
Pemphigus | 214.00 | 9.76 | 798 | 367776 | 59903 | 64070255 |
Intentional product use issue | 211.68 | 9.76 | 1091 | 367483 | 94273 | 64035885 |
Coagulopathy | 209.41 | 9.76 | 522 | 368052 | 31398 | 64098760 |
Pericarditis | 208.96 | 9.76 | 808 | 367766 | 61708 | 64068450 |
Respiratory arrest | 205.85 | 9.76 | 719 | 367855 | 52266 | 64077892 |
Cardio-respiratory arrest | 194.85 | 9.76 | 1091 | 367483 | 97302 | 64032856 |
Diarrhoea | 192.00 | 9.76 | 2942 | 365632 | 719762 | 63410396 |
Hepatic cytolysis | 187.82 | 9.76 | 309 | 368265 | 13740 | 64116418 |
Medication error | 187.20 | 9.76 | 670 | 367904 | 49296 | 64080862 |
Ill-defined disorder | 186.26 | 9.76 | 615 | 367959 | 43437 | 64086721 |
Myocardial infarction | 185.41 | 9.76 | 421 | 368153 | 165400 | 63964758 |
Nasopharyngitis | 184.01 | 9.76 | 1820 | 366754 | 194253 | 63935905 |
Hepatic necrosis | 183.12 | 9.76 | 234 | 368340 | 8239 | 64121919 |
Glossodynia | 177.54 | 9.76 | 787 | 367787 | 63909 | 64066249 |
Depressed level of consciousness | 176.11 | 9.76 | 925 | 367649 | 80511 | 64049647 |
Wound | 175.34 | 9.76 | 883 | 367691 | 75594 | 64054564 |
Blister | 170.52 | 9.76 | 913 | 367661 | 80054 | 64050104 |
Blood pressure diastolic abnormal | 167.32 | 9.76 | 268 | 368306 | 11649 | 64118509 |
Joint swelling | 162.98 | 9.76 | 1915 | 366659 | 213467 | 63916691 |
Anaemia | 158.62 | 9.76 | 1392 | 367182 | 377288 | 63752870 |
Oxygen saturation decreased | 158.11 | 9.76 | 1102 | 367472 | 106074 | 64024084 |
Discomfort | 153.01 | 9.76 | 886 | 367688 | 79992 | 64050166 |
Systemic lupus erythematosus | 151.26 | 9.76 | 857 | 367717 | 76755 | 64053403 |
Poisoning | 147.95 | 9.76 | 362 | 368212 | 21517 | 64108641 |
Analgesic drug level increased | 146.76 | 9.76 | 114 | 368460 | 2156 | 64128002 |
Synovitis | 145.65 | 9.76 | 1018 | 367556 | 98072 | 64032086 |
Impaired healing | 144.84 | 9.76 | 707 | 367867 | 59766 | 64070392 |
Cardiac failure congestive | 144.75 | 9.76 | 333 | 368241 | 130247 | 63999911 |
Respiratory depression | 141.97 | 9.76 | 372 | 368202 | 23071 | 64107087 |
Injection site erythema | 140.07 | 9.76 | 119 | 368455 | 70681 | 64059477 |
Body temperature increased | 138.48 | 9.76 | 493 | 368081 | 36173 | 64093985 |
Drug interaction | 136.16 | 9.76 | 1367 | 367207 | 360716 | 63769442 |
Liver injury | 135.70 | 9.76 | 428 | 368146 | 29504 | 64100654 |
Weight increased | 134.97 | 9.76 | 1835 | 366739 | 211513 | 63918645 |
Suspected suicide | 134.57 | 9.76 | 204 | 368370 | 8450 | 64121708 |
Blood pressure diastolic decreased | 134.16 | 9.76 | 353 | 368221 | 21948 | 64108210 |
Blood pressure systolic increased | 132.98 | 9.76 | 598 | 367976 | 48855 | 64081303 |
Sedation complication | 132.08 | 9.76 | 223 | 368351 | 10131 | 64120027 |
Drug resistance | 130.01 | 9.76 | 22 | 368552 | 35080 | 64095078 |
Blood pressure systolic abnormal | 129.32 | 9.76 | 216 | 368358 | 9726 | 64120432 |
Drug ineffective | 122.90 | 9.76 | 3763 | 364811 | 836484 | 63293674 |
Therapeutic product effect decreased | 120.68 | 9.76 | 1096 | 367478 | 114255 | 64015903 |
Wrong technique in product usage process | 119.27 | 9.76 | 117 | 368457 | 64857 | 64065301 |
Sopor | 118.16 | 9.76 | 15 | 368559 | 29646 | 64100512 |
Hepatic failure | 116.85 | 9.76 | 625 | 367949 | 54769 | 64075389 |
Heart rate irregular | 112.57 | 9.76 | 379 | 368195 | 27034 | 64103124 |
Psoriasis | 111.13 | 9.76 | 148 | 368426 | 71555 | 64058603 |
Creatinine renal clearance decreased | 111.00 | 9.76 | 251 | 368323 | 14170 | 64115988 |
Cardiac failure | 110.93 | 9.76 | 386 | 368188 | 131987 | 63998171 |
Accidental overdose | 109.89 | 9.76 | 431 | 368143 | 33126 | 64097032 |
Heart rate increased | 109.11 | 9.76 | 949 | 367625 | 97726 | 64032432 |
Exposure via ingestion | 106.91 | 9.76 | 136 | 368438 | 4766 | 64125392 |
Throat irritation | 103.79 | 9.76 | 416 | 368158 | 32295 | 64097863 |
Arthropathy | 102.96 | 9.76 | 1101 | 367473 | 119866 | 64010292 |
Swelling | 102.90 | 9.76 | 1382 | 367192 | 158836 | 63971322 |
Blood calcium decreased | 102.03 | 9.76 | 350 | 368224 | 25204 | 64104954 |
Hypotension | 99.69 | 9.76 | 2866 | 365708 | 378108 | 63752050 |
Acute lung injury | 97.67 | 9.76 | 98 | 368476 | 2633 | 64127525 |
Device expulsion | 96.79 | 9.76 | 6 | 368568 | 21130 | 64109028 |
Pyroglutamic acidosis | 95.79 | 9.76 | 57 | 368517 | 679 | 64129479 |
Coma | 93.94 | 9.76 | 837 | 367737 | 86778 | 64043380 |
Osteonecrosis of jaw | 93.10 | 9.76 | 56 | 368518 | 39769 | 64090389 |
Injection site reaction | 92.83 | 9.76 | 78 | 368496 | 46586 | 64083572 |
Death | 92.79 | 9.76 | 3501 | 365073 | 479204 | 63650954 |
Bone marrow failure | 89.57 | 9.76 | 85 | 368489 | 47867 | 64082291 |
Substance abuse | 88.03 | 9.76 | 176 | 368398 | 9116 | 64121042 |
Gastrointestinal disorder | 87.60 | 9.76 | 840 | 367734 | 88869 | 64041289 |
Neutropenia | 84.51 | 9.76 | 918 | 367656 | 238706 | 63891452 |
Injection site pruritus | 83.21 | 9.76 | 57 | 368517 | 37769 | 64092389 |
Interstitial lung disease | 81.18 | 9.76 | 286 | 368288 | 97446 | 64032712 |
Injection site swelling | 81.18 | 9.76 | 70 | 368504 | 41283 | 64088875 |
Injection site bruising | 79.76 | 9.76 | 55 | 368519 | 36318 | 64093840 |
Alanine aminotransferase increased | 79.49 | 9.76 | 1175 | 367399 | 137856 | 63992302 |
Body temperature decreased | 77.71 | 9.76 | 324 | 368250 | 25604 | 64104554 |
Cerebrovascular accident | 77.67 | 9.76 | 464 | 368110 | 137119 | 63993039 |
Disease progression | 76.76 | 9.76 | 484 | 368090 | 141196 | 63988962 |
Product use in unapproved indication | 76.11 | 9.76 | 644 | 367930 | 175974 | 63954184 |
Coronary artery disease | 72.84 | 9.76 | 147 | 368427 | 60286 | 64069872 |
Blood pressure diastolic increased | 72.80 | 9.76 | 178 | 368396 | 10574 | 64119584 |
Decreased appetite | 72.27 | 9.76 | 1151 | 367423 | 280138 | 63850020 |
Contraindicated product administered | 71.22 | 9.76 | 935 | 367639 | 106894 | 64023264 |
Hypersensitivity | 70.96 | 9.76 | 1544 | 367030 | 194908 | 63935250 |
Drug abuse | 69.62 | 9.76 | 1103 | 367471 | 131271 | 63998887 |
Ear pain | 69.10 | 9.76 | 306 | 368268 | 24830 | 64105328 |
Hospitalisation | 68.73 | 9.76 | 211 | 368363 | 74996 | 64055162 |
Renal impairment | 67.72 | 9.76 | 472 | 368102 | 134545 | 63995613 |
Product prescribing error | 64.15 | 9.76 | 64 | 368510 | 35205 | 64094953 |
Neutrophil percentage increased | 63.82 | 9.76 | 101 | 368473 | 4344 | 64125814 |
Therapeutic product effect incomplete | 63.81 | 9.76 | 339 | 368235 | 103143 | 64027015 |
Oedema peripheral | 63.67 | 9.76 | 833 | 367741 | 209484 | 63920674 |
Malignant neoplasm progression | 63.52 | 9.76 | 381 | 368193 | 112490 | 64017668 |
Rheumatoid factor positive | 61.71 | 9.76 | 376 | 368198 | 34562 | 64095596 |
Dizziness | 61.44 | 9.76 | 1931 | 366643 | 428232 | 63701926 |
Neuropathy peripheral | 61.35 | 9.76 | 406 | 368168 | 117119 | 64013039 |
Pancytopenia | 61.08 | 9.76 | 524 | 368050 | 142785 | 63987373 |
White blood cells urine positive | 60.72 | 9.76 | 110 | 368464 | 5288 | 64124870 |
Anion gap abnormal | 60.50 | 9.76 | 38 | 368536 | 502 | 64129656 |
Respiratory rate increased | 60.46 | 9.76 | 236 | 368338 | 18095 | 64112063 |
Cognitive disorder | 59.93 | 9.76 | 528 | 368046 | 54559 | 64075599 |
Mucosal inflammation | 59.77 | 9.76 | 172 | 368402 | 62412 | 64067746 |
Sedation | 59.73 | 9.76 | 424 | 368150 | 41038 | 64089120 |
Crystal urine present | 59.60 | 9.76 | 64 | 368510 | 1865 | 64128293 |
Feeling abnormal | 59.43 | 9.76 | 483 | 368091 | 133119 | 63997039 |
International normalised ratio increased | 58.92 | 9.76 | 702 | 367872 | 78465 | 64051693 |
Electric shock | 56.80 | 9.76 | 49 | 368525 | 1080 | 64129078 |
Therapy cessation | 56.78 | 9.76 | 61 | 368513 | 32428 | 64097730 |
Dyspnoea | 56.69 | 9.76 | 3447 | 365127 | 715227 | 63414931 |
Pyroglutamate increased | 56.53 | 9.76 | 39 | 368535 | 609 | 64129549 |
Urine abnormality | 56.51 | 9.76 | 128 | 368446 | 7234 | 64122924 |
Suicide attempt | 56.12 | 9.76 | 637 | 367937 | 70370 | 64059788 |
Aspartate aminotransferase increased | 55.94 | 9.76 | 979 | 367595 | 118809 | 64011349 |
Lymphocyte percentage decreased | 55.19 | 9.76 | 97 | 368477 | 4552 | 64125606 |
Therapeutic response shortened | 55.18 | 9.76 | 155 | 368419 | 10015 | 64120143 |
Blood pH decreased | 53.76 | 9.76 | 93 | 368481 | 4309 | 64125849 |
Injection site warmth | 53.16 | 9.76 | 7 | 368567 | 13455 | 64116703 |
Poor venous access | 53.05 | 9.76 | 174 | 368400 | 12243 | 64117915 |
Arthralgia | 52.96 | 9.76 | 3060 | 365514 | 439200 | 63690958 |
Pneumonia | 52.35 | 9.76 | 2639 | 365935 | 556937 | 63573221 |
Body temperature fluctuation | 51.64 | 9.76 | 78 | 368496 | 3220 | 64126938 |
Diabetes mellitus | 50.33 | 9.76 | 202 | 368372 | 66272 | 64063886 |
Peripheral swelling | 49.33 | 9.76 | 1554 | 367020 | 207599 | 63922559 |
Stomatitis | 48.77 | 9.76 | 889 | 367685 | 108716 | 64021442 |
Product quality issue | 48.77 | 9.76 | 59 | 368515 | 29740 | 64100418 |
Cytokine release syndrome | 48.06 | 9.76 | 241 | 368333 | 20588 | 64109570 |
Drug ineffective for unapproved indication | 47.48 | 9.76 | 65 | 368509 | 31068 | 64099090 |
Acute kidney injury | 47.28 | 9.76 | 2092 | 366482 | 447148 | 63683010 |
Cerebral haemorrhage | 46.92 | 9.76 | 143 | 368431 | 50947 | 64079211 |
Muscle spasms | 46.24 | 9.76 | 549 | 368025 | 140474 | 63989684 |
Posterior reversible encephalopathy syndrome | 46.07 | 9.76 | 38 | 368536 | 22908 | 64107250 |
Dehydration | 45.48 | 9.76 | 919 | 367655 | 215844 | 63914314 |
Acute myocardial infarction | 45.46 | 9.76 | 224 | 368350 | 69494 | 64060664 |
Hyperlipidaemia | 44.97 | 9.76 | 39 | 368535 | 22937 | 64107221 |
Epistaxis | 44.91 | 9.76 | 352 | 368222 | 97779 | 64032379 |
Leukopenia | 44.56 | 9.76 | 367 | 368207 | 100875 | 64029283 |
Drug hypersensitivity | 44.48 | 9.76 | 1027 | 367547 | 236788 | 63893370 |
Muscle spasticity | 44.37 | 9.76 | 201 | 368373 | 16468 | 64113690 |
Palmar-plantar erythrodysaesthesia syndrome | 44.12 | 9.76 | 60 | 368514 | 28759 | 64101399 |
Lymphocyte count decreased | 43.70 | 9.76 | 389 | 368185 | 40310 | 64089848 |
Gait disturbance | 43.64 | 9.76 | 706 | 367868 | 171449 | 63958709 |
Prothrombin time prolonged | 43.55 | 9.76 | 192 | 368382 | 15549 | 64114609 |
Hyperkalaemia | 43.42 | 9.76 | 369 | 368205 | 100760 | 64029398 |
Septic shock | 43.38 | 9.76 | 389 | 368185 | 105048 | 64025110 |
Atrial fibrillation | 43.25 | 9.76 | 702 | 367872 | 170387 | 63959771 |
Visual acuity reduced | 43.09 | 9.76 | 55 | 368519 | 27086 | 64103072 |
Infusion site extravasation | 42.94 | 9.76 | 110 | 368464 | 6727 | 64123431 |
Myelosuppression | 42.48 | 9.76 | 44 | 368530 | 23786 | 64106372 |
Neoplasm progression | 41.79 | 9.76 | 109 | 368465 | 40855 | 64089303 |
Underdose | 41.36 | 9.76 | 52 | 368522 | 25777 | 64104381 |
Cytomegalovirus infection | 41.08 | 9.76 | 95 | 368479 | 37104 | 64093054 |
Urinary sediment present | 41.06 | 9.76 | 57 | 368517 | 2177 | 64127981 |
Cerebral infarction | 40.52 | 9.76 | 111 | 368463 | 40933 | 64089225 |
Orthostatic hypotension | 40.48 | 9.76 | 427 | 368147 | 46311 | 64083847 |
Device issue | 40.16 | 9.76 | 42 | 368532 | 22606 | 64107552 |
Product storage error | 40.14 | 9.76 | 13 | 368561 | 13305 | 64116853 |
Injection site rash | 39.89 | 9.76 | 20 | 368554 | 15722 | 64114436 |
Paraesthesia | 39.88 | 9.76 | 535 | 368039 | 133987 | 63996171 |
Memory impairment | 39.83 | 9.76 | 306 | 368268 | 85376 | 64044782 |
Injection site haemorrhage | 39.80 | 9.76 | 48 | 368526 | 24230 | 64105928 |
Infusion site pain | 39.42 | 9.76 | 140 | 368434 | 10257 | 64119901 |
Red cell distribution width increased | 39.41 | 9.76 | 157 | 368417 | 12152 | 64118006 |
Injection site mass | 39.37 | 9.76 | 25 | 368549 | 17245 | 64112913 |
Flushing | 39.33 | 9.76 | 650 | 367924 | 77998 | 64052160 |
Product substitution issue | 39.17 | 9.76 | 27 | 368547 | 17834 | 64112324 |
Brain death | 38.97 | 9.76 | 86 | 368488 | 4775 | 64125383 |
Cardiac arrest | 38.25 | 9.76 | 1152 | 367422 | 152912 | 63977246 |
Haematotoxicity | 38.14 | 9.76 | 13 | 368561 | 12883 | 64117275 |
Urine leukocyte esterase positive | 37.84 | 9.76 | 69 | 368505 | 3334 | 64126824 |
Contusion | 37.75 | 9.76 | 885 | 367689 | 113080 | 64017078 |
Dyspnoea exertional | 37.32 | 9.76 | 257 | 368317 | 73473 | 64056685 |
Electrocardiogram QT prolonged | 37.28 | 9.76 | 283 | 368291 | 79165 | 64050993 |
Surgery | 37.19 | 9.76 | 65 | 368509 | 28148 | 64102010 |
Syncope | 37.17 | 9.76 | 655 | 367919 | 156980 | 63973178 |
Loss of personal independence in daily activities | 36.95 | 9.76 | 252 | 368322 | 72202 | 64057956 |
Rheumatic fever | 36.84 | 9.76 | 127 | 368447 | 9167 | 64120991 |
Drug intolerance | 36.32 | 9.76 | 1365 | 367209 | 186627 | 63943531 |
Haemolysis | 36.31 | 9.76 | 142 | 368432 | 10897 | 64119261 |
Immune reconstitution inflammatory syndrome | 36.15 | 9.76 | 13 | 368561 | 12457 | 64117701 |
Fall | 35.66 | 9.76 | 1983 | 366591 | 414843 | 63715315 |
Device malfunction | 35.65 | 9.76 | 29 | 368545 | 17604 | 64112554 |
Pain | 35.45 | 9.76 | 3646 | 364928 | 549865 | 63580293 |
Asthenia | 35.06 | 9.76 | 2045 | 366529 | 425999 | 63704159 |
Transient ischaemic attack | 34.89 | 9.76 | 132 | 368442 | 44050 | 64086108 |
Diabetic ketoacidosis | 34.77 | 9.76 | 74 | 368500 | 29771 | 64100387 |
Urticaria | 34.56 | 9.76 | 1094 | 367480 | 146223 | 63983935 |
Red blood cell sedimentation rate abnormal | 34.00 | 9.76 | 26 | 368548 | 16280 | 64113878 |
Jaundice cholestatic | 33.95 | 9.76 | 118 | 368456 | 8552 | 64121606 |
Second primary malignancy | 33.87 | 9.76 | 14 | 368560 | 12323 | 64117835 |
Specific gravity urine decreased | 33.48 | 9.76 | 31 | 368543 | 752 | 64129406 |
Red blood cells urine positive | 33.42 | 9.76 | 77 | 368497 | 4401 | 64125757 |
Myelodysplastic syndrome | 33.30 | 9.76 | 67 | 368507 | 27512 | 64102646 |
Pathogen resistance | 33.22 | 9.76 | 15 | 368559 | 12528 | 64117630 |
Infusion site pruritus | 33.07 | 9.76 | 56 | 368518 | 2550 | 64127608 |
Acidosis | 33.01 | 9.76 | 194 | 368380 | 17601 | 64112557 |
Analgesic drug level above therapeutic | 32.96 | 9.76 | 24 | 368550 | 410 | 64129748 |
General physical health deterioration | 32.77 | 9.76 | 903 | 367671 | 203522 | 63926636 |
Therapy interrupted | 32.44 | 9.76 | 40 | 368534 | 19996 | 64110162 |
Device difficult to use | 32.43 | 9.76 | 8 | 368566 | 9790 | 64120368 |
Infusion site swelling | 32.35 | 9.76 | 86 | 368488 | 5379 | 64124779 |
Injection site induration | 32.20 | 9.76 | 6 | 368568 | 8926 | 64121232 |
Unresponsive to stimuli | 32.02 | 9.76 | 434 | 368140 | 49959 | 64080199 |
Brain oedema | 31.94 | 9.76 | 226 | 368348 | 21849 | 64108309 |
Renal failure | 31.91 | 9.76 | 792 | 367782 | 180896 | 63949262 |
Unevaluable event | 31.90 | 9.76 | 164 | 368410 | 50325 | 64079833 |
Anion gap increased | 31.69 | 9.76 | 60 | 368514 | 2984 | 64127174 |
Nausea | 31.64 | 9.76 | 3971 | 364603 | 781829 | 63348329 |
Loss of consciousness | 31.41 | 9.76 | 628 | 367946 | 147737 | 63982421 |
Malaise | 31.38 | 9.76 | 1899 | 366675 | 394348 | 63735810 |
Blood parathyroid hormone decreased | 31.17 | 9.76 | 3 | 368571 | 7363 | 64122795 |
Ear pruritus | 30.93 | 9.76 | 55 | 368519 | 2605 | 64127553 |
Device dislocation | 30.53 | 9.76 | 46 | 368528 | 21132 | 64109026 |
Haematuria | 30.50 | 9.76 | 211 | 368363 | 60260 | 64069898 |
Gastrointestinal haemorrhage | 30.48 | 9.76 | 552 | 368022 | 131760 | 63998398 |
Injection site urticaria | 30.20 | 9.76 | 13 | 368561 | 11168 | 64118990 |
Renal papillary necrosis | 29.64 | 9.76 | 21 | 368553 | 343 | 64129815 |
Extrapyramidal disorder | 29.63 | 9.76 | 41 | 368533 | 19511 | 64110647 |
Pruritus | 29.41 | 9.76 | 2118 | 366456 | 310282 | 63819876 |
Post transplant lymphoproliferative disorder | 29.33 | 9.76 | 9 | 368565 | 9535 | 64120623 |
Night sweats | 29.21 | 9.76 | 325 | 368249 | 35721 | 64094437 |
Glycosylated haemoglobin increased | 29.21 | 9.76 | 29 | 368545 | 15990 | 64114168 |
No adverse event | 29.13 | 9.76 | 76 | 368498 | 28485 | 64101673 |
Infusion site erythema | 29.08 | 9.76 | 96 | 368478 | 6777 | 64123381 |
Liver transplant | 29.05 | 9.76 | 69 | 368505 | 4023 | 64126135 |
Bacterial test | 28.75 | 9.76 | 35 | 368539 | 1172 | 64128986 |
Cardiac failure chronic | 28.74 | 9.76 | 8 | 368566 | 9033 | 64121125 |
Urine analysis abnormal | 28.60 | 9.76 | 85 | 368489 | 5671 | 64124487 |
Epilepsy | 28.59 | 9.76 | 97 | 368477 | 33434 | 64096724 |
Drug-induced liver injury | 28.52 | 9.76 | 406 | 368168 | 47237 | 64082921 |
Disturbance in attention | 28.52 | 9.76 | 129 | 368445 | 40945 | 64089213 |
Depression | 28.51 | 9.76 | 813 | 367761 | 182478 | 63947680 |
Iron deficiency anaemia | 28.34 | 9.76 | 51 | 368523 | 21838 | 64108320 |
Labelled drug-drug interaction medication error | 28.03 | 9.76 | 52 | 368522 | 22010 | 64108148 |
Hypertensive crisis | 27.92 | 9.76 | 38 | 368536 | 18210 | 64111948 |
Hypocalcaemia | 27.88 | 9.76 | 133 | 368441 | 41620 | 64088538 |
Full blood count abnormal | 27.53 | 9.76 | 83 | 368491 | 29674 | 64100484 |
Swollen joint count increased | 27.01 | 9.76 | 101 | 368473 | 7588 | 64122570 |
Maternal exposure during pregnancy | 26.84 | 9.76 | 728 | 367846 | 95156 | 64035002 |
Bilirubin urine present | 26.78 | 9.76 | 19 | 368555 | 311 | 64129847 |
Multiple-drug resistance | 26.61 | 9.76 | 3 | 368571 | 6499 | 64123659 |
Sexual dysfunction | 26.45 | 9.76 | 3 | 368571 | 6468 | 64123690 |
Lactic acidosis | 26.39 | 9.76 | 224 | 368350 | 61186 | 64068972 |
Abortion spontaneous | 26.34 | 9.76 | 66 | 368508 | 25077 | 64105081 |
Soft tissue disorder | 26.31 | 9.76 | 58 | 368516 | 3218 | 64126940 |
Hyponatraemia | 26.21 | 9.76 | 646 | 367928 | 147693 | 63982465 |
Osteonecrosis | 25.92 | 9.76 | 79 | 368495 | 28150 | 64102008 |
Myalgia | 25.58 | 9.76 | 700 | 367874 | 157917 | 63972241 |
Bursitis | 25.50 | 9.76 | 210 | 368364 | 21275 | 64108883 |
Transaminases increased | 25.50 | 9.76 | 377 | 368197 | 44217 | 64085941 |
C-reactive protein abnormal | 25.47 | 9.76 | 83 | 368491 | 28964 | 64101194 |
Multiple drug therapy | 25.44 | 9.76 | 46 | 368528 | 2208 | 64127950 |
Drug screen positive | 25.12 | 9.76 | 81 | 368493 | 5648 | 64124510 |
Abdominal discomfort | 25.02 | 9.76 | 1278 | 367296 | 181044 | 63949114 |
Thrombocytopenia | 24.76 | 9.76 | 1036 | 367538 | 222765 | 63907393 |
Thinking abnormal | 24.64 | 9.76 | 18 | 368556 | 11538 | 64118620 |
Hepatic encephalopathy | 24.52 | 9.76 | 205 | 368369 | 20861 | 64109297 |
Lung neoplasm malignant | 24.31 | 9.76 | 54 | 368520 | 21394 | 64108764 |
Drug level below therapeutic | 24.30 | 9.76 | 95 | 368479 | 7289 | 64122869 |
Aplastic anaemia | 24.07 | 9.76 | 149 | 368425 | 13771 | 64116387 |
Cardiac failure acute | 24.05 | 9.76 | 35 | 368539 | 16309 | 64113849 |
Fracture | 24.01 | 9.76 | 44 | 368530 | 18711 | 64111447 |
Renal cortical necrosis | 23.97 | 9.76 | 17 | 368557 | 278 | 64129880 |
Asthma | 23.95 | 9.76 | 391 | 368183 | 94834 | 64035324 |
Forced expiratory volume decreased | 23.94 | 9.76 | 5 | 368569 | 6862 | 64123296 |
Angina unstable | 23.88 | 9.76 | 32 | 368542 | 15435 | 64114723 |
Acute graft versus host disease | 23.84 | 9.76 | 11 | 368563 | 9073 | 64121085 |
Blood urine present | 23.82 | 9.76 | 183 | 368391 | 18157 | 64112001 |
Inappropriate antidiuretic hormone secretion | 23.75 | 9.76 | 58 | 368516 | 22231 | 64107927 |
Smear cervix abnormal | 23.74 | 9.76 | 46 | 368528 | 2328 | 64127830 |
Psoriatic arthropathy | 23.34 | 9.76 | 148 | 368426 | 43133 | 64087025 |
Vision blurred | 23.33 | 9.76 | 369 | 368205 | 89947 | 64040211 |
Toxic epidermal necrolysis | 23.17 | 9.76 | 319 | 368255 | 36847 | 64093311 |
Acute myeloid leukaemia | 23.04 | 9.76 | 80 | 368494 | 27383 | 64102775 |
Graft versus host disease | 22.97 | 9.76 | 27 | 368547 | 13786 | 64116372 |
Tremor | 22.92 | 9.76 | 658 | 367916 | 147572 | 63982586 |
Angina pectoris | 22.88 | 9.76 | 157 | 368417 | 44924 | 64085234 |
Seizure | 22.83 | 9.76 | 753 | 367821 | 166139 | 63964019 |
Temperature regulation disorder | 22.67 | 9.76 | 64 | 368510 | 4147 | 64126011 |
Infusion site mass | 22.64 | 9.76 | 28 | 368546 | 953 | 64129205 |
Basal cell carcinoma | 22.53 | 9.76 | 95 | 368479 | 30743 | 64099415 |
Coronary arterial stent insertion | 22.38 | 9.76 | 3 | 368571 | 5689 | 64124469 |
Spinal stenosis | 22.35 | 9.76 | 28 | 368546 | 13903 | 64116255 |
Full blood count decreased | 22.34 | 9.76 | 61 | 368513 | 22521 | 64107637 |
Prostate cancer | 22.30 | 9.76 | 50 | 368524 | 19745 | 64110413 |
Culture urine positive | 22.26 | 9.76 | 63 | 368511 | 4088 | 64126070 |
Hypomania | 22.18 | 9.76 | 77 | 368497 | 5577 | 64124581 |
Intervertebral discitis | 22.13 | 9.76 | 60 | 368514 | 3797 | 64126361 |
Granuloma skin | 22.07 | 9.76 | 4 | 368570 | 6070 | 64124088 |
Appendicolith | 21.98 | 9.76 | 56 | 368518 | 3413 | 64126745 |
Cardiomyopathy | 21.86 | 9.76 | 73 | 368501 | 25283 | 64104875 |
Blood creatinine decreased | 21.83 | 9.76 | 89 | 368485 | 6961 | 64123197 |
Status epilepticus | 21.83 | 9.76 | 58 | 368516 | 21605 | 64108553 |
Rash pruritic | 21.80 | 9.76 | 216 | 368358 | 57188 | 64072970 |
Therapeutic response unexpected | 21.66 | 9.76 | 40 | 368534 | 16961 | 64113197 |
Hypothermia | 21.42 | 9.76 | 190 | 368384 | 19666 | 64110492 |
Withdrawal syndrome | 21.39 | 9.76 | 66 | 368508 | 23426 | 64106732 |
Granulomatosis with polyangiitis | 21.10 | 9.76 | 41 | 368533 | 2079 | 64128079 |
Oedema | 21.03 | 9.76 | 384 | 368190 | 91551 | 64038607 |
Concomitant disease aggravated | 20.93 | 9.76 | 21 | 368553 | 11521 | 64118637 |
Haemorrhage | 20.90 | 9.76 | 323 | 368251 | 79028 | 64051130 |
Pneumocystis jirovecii pneumonia | 20.90 | 9.76 | 84 | 368490 | 27550 | 64102608 |
Metastases to lymph nodes | 20.73 | 9.76 | 12 | 368562 | 8705 | 64121453 |
Endophthalmitis | 20.69 | 9.76 | 3 | 368571 | 5362 | 64124796 |
Confusional state | 20.69 | 9.76 | 1747 | 366827 | 259397 | 63870761 |
Mobility decreased | 20.52 | 9.76 | 639 | 367935 | 85201 | 64044957 |
Thrombotic microangiopathy | 20.51 | 9.76 | 40 | 368534 | 16615 | 64113543 |
Pain in extremity | 20.50 | 9.76 | 1473 | 367101 | 301612 | 63828546 |
Hypercalcaemia | 20.44 | 9.76 | 101 | 368473 | 31315 | 64098843 |
Monocyte percentage increased | 20.30 | 9.76 | 39 | 368535 | 1961 | 64128197 |
Rash | 20.19 | 9.76 | 2951 | 365623 | 455598 | 63674560 |
Blood triglycerides increased | 20.18 | 9.76 | 49 | 368525 | 18817 | 64111341 |
Haematochezia | 20.01 | 9.76 | 263 | 368311 | 66110 | 64064048 |
Deep vein thrombosis | 19.98 | 9.76 | 453 | 368121 | 104729 | 64025429 |
Cardiac disorder | 19.97 | 9.76 | 213 | 368361 | 55603 | 64074555 |
Suicidal ideation | 19.94 | 9.76 | 264 | 368310 | 66278 | 64063880 |
Ageusia | 19.92 | 9.76 | 30 | 368544 | 13783 | 64116375 |
Hepatic cirrhosis | 19.85 | 9.76 | 80 | 368494 | 26218 | 64103940 |
Myopathy | 19.64 | 9.76 | 45 | 368529 | 17635 | 64112523 |
Dry skin | 19.64 | 9.76 | 192 | 368382 | 50969 | 64079189 |
Aspergillus infection | 19.60 | 9.76 | 40 | 368534 | 16339 | 64113819 |
Poisoning deliberate | 19.60 | 9.76 | 138 | 368436 | 13320 | 64116838 |
Infection | 19.58 | 9.76 | 1266 | 367308 | 183614 | 63946544 |
Bacterial test positive | 19.58 | 9.76 | 83 | 368491 | 6607 | 64123551 |
Hypomagnesaemia | 19.55 | 9.76 | 129 | 368445 | 37247 | 64092911 |
Polyneuropathy | 19.49 | 9.76 | 54 | 368520 | 19840 | 64110318 |
Angioedema | 19.36 | 9.76 | 243 | 368331 | 61578 | 64068580 |
Speech disorder | 19.36 | 9.76 | 180 | 368394 | 48261 | 64081897 |
Hemiparesis | 19.34 | 9.76 | 96 | 368478 | 29731 | 64100427 |
Inappropriate schedule of product administration | 19.25 | 9.76 | 676 | 367898 | 91610 | 64038548 |
Cytopenia | 19.18 | 9.76 | 37 | 368537 | 15434 | 64114724 |
Pharyngeal paraesthesia | 18.99 | 9.76 | 37 | 368537 | 1880 | 64128278 |
Subdural haematoma | 18.94 | 9.76 | 89 | 368485 | 27965 | 64102193 |
Carotid artery stenosis | 18.79 | 9.76 | 11 | 368563 | 7930 | 64122228 |
Coronary artery bypass | 18.76 | 9.76 | 5 | 368569 | 5810 | 64124348 |
Alopecia | 18.73 | 9.76 | 1141 | 367433 | 164549 | 63965609 |
Febrile bone marrow aplasia | 18.72 | 9.76 | 22 | 368552 | 11233 | 64118925 |
Methaemoglobinaemia | 18.64 | 9.76 | 61 | 368513 | 4287 | 64125871 |
Maternal exposure timing unspecified | 18.52 | 9.76 | 45 | 368529 | 2662 | 64127496 |
Accidental death | 18.50 | 9.76 | 55 | 368519 | 3670 | 64126488 |
Neurotoxicity | 18.47 | 9.76 | 87 | 368487 | 27317 | 64102841 |
Urine bilirubin decreased | 18.20 | 9.76 | 11 | 368563 | 135 | 64130023 |
Hepatocellular carcinoma | 18.03 | 9.76 | 13 | 368561 | 8390 | 64121768 |
Osmolar gap | 18.00 | 9.76 | 11 | 368563 | 138 | 64130020 |
Toxicologic test abnormal | 17.82 | 9.76 | 28 | 368546 | 1197 | 64128961 |
Pulmonary embolism | 17.80 | 9.76 | 670 | 367904 | 145686 | 63984472 |
Transplant dysfunction | 17.80 | 9.76 | 8 | 368566 | 6700 | 64123458 |
Chills | 17.78 | 9.76 | 957 | 367617 | 136307 | 63993851 |
Dysarthria | 17.69 | 9.76 | 236 | 368338 | 59170 | 64070988 |
Gestational diabetes | 17.67 | 9.76 | 5 | 368569 | 5585 | 64124573 |
Aphasia | 17.67 | 9.76 | 149 | 368425 | 40757 | 64089401 |
Precancerous cells present | 17.59 | 9.76 | 25 | 368549 | 976 | 64129182 |
Platelet count decreased | 17.58 | 9.76 | 781 | 367793 | 166930 | 63963228 |
Chronic graft versus host disease | 17.43 | 9.76 | 7 | 368567 | 6269 | 64123889 |
Mean cell haemoglobin concentration increased | 17.42 | 9.76 | 22 | 368552 | 765 | 64129393 |
Sputum culture positive | 17.29 | 9.76 | 47 | 368527 | 2979 | 64127179 |
Band neutrophil count increased | 17.26 | 9.76 | 20 | 368554 | 635 | 64129523 |
Chest pain | 17.25 | 9.76 | 1139 | 367435 | 234841 | 63895317 |
Thrombosis | 17.13 | 9.76 | 292 | 368282 | 70350 | 64059808 |
Prostatic specific antigen increased | 16.98 | 9.76 | 15 | 368559 | 8745 | 64121413 |
Sepsis | 16.97 | 9.76 | 1111 | 367463 | 229230 | 63900928 |
Infusion site bruising | 16.95 | 9.76 | 31 | 368543 | 1501 | 64128657 |
Pyrexia | 16.91 | 9.76 | 3525 | 365049 | 555119 | 63575039 |
Bone erosion | 16.89 | 9.76 | 25 | 368549 | 11570 | 64118588 |
Serum sickness | 16.71 | 9.76 | 48 | 368526 | 3141 | 64127017 |
Akathisia | 16.59 | 9.76 | 25 | 368549 | 11485 | 64118673 |
Graft versus host disease in skin | 16.51 | 9.76 | 5 | 368569 | 5342 | 64124816 |
Transplant rejection | 16.48 | 9.76 | 48 | 368526 | 17353 | 64112805 |
Hypokalaemia | 16.43 | 9.76 | 551 | 368023 | 121352 | 64008806 |
Burning sensation | 16.40 | 9.76 | 193 | 368381 | 49471 | 64080687 |
Congestive cardiomyopathy | 16.38 | 9.76 | 21 | 368553 | 10323 | 64119835 |
Pulmonary mass | 16.33 | 9.76 | 76 | 368498 | 23940 | 64106218 |
Vertigo | 16.30 | 9.76 | 238 | 368336 | 58773 | 64071385 |
Panniculitis | 16.28 | 9.76 | 16 | 368558 | 8863 | 64121295 |
Fluid retention | 16.25 | 9.76 | 241 | 368333 | 59365 | 64070793 |
Chronic obstructive pulmonary disease | 16.17 | 9.76 | 297 | 368277 | 70751 | 64059407 |
Haematocrit decreased | 16.16 | 9.76 | 418 | 368156 | 54237 | 64075921 |
Tachycardia | 16.15 | 9.76 | 1026 | 367548 | 148553 | 63981605 |
Visual impairment | 16.14 | 9.76 | 312 | 368262 | 73765 | 64056393 |
Mania | 16.11 | 9.76 | 44 | 368530 | 16242 | 64113916 |
Dyspnoea at rest | 16.10 | 9.76 | 8 | 368566 | 6321 | 64123837 |
Ejection fraction decreased | 16.08 | 9.76 | 97 | 368477 | 28610 | 64101548 |
Mean cell haemoglobin concentration decreased | 16.07 | 9.76 | 52 | 368522 | 3632 | 64126526 |
Skin ulcer | 16.06 | 9.76 | 167 | 368407 | 43807 | 64086351 |
Eosinophil percentage increased | 15.99 | 9.76 | 29 | 368545 | 1395 | 64128763 |
Left ventricular dysfunction | 15.89 | 9.76 | 47 | 368527 | 16907 | 64113251 |
Haemoglobin urine present | 15.83 | 9.76 | 22 | 368552 | 841 | 64129317 |
Blood bilirubin increased | 15.82 | 9.76 | 436 | 368138 | 57117 | 64073041 |
Right ventricular failure | 15.78 | 9.76 | 66 | 368508 | 21405 | 64108753 |
COVID-19 immunisation | 15.75 | 9.76 | 18 | 368556 | 563 | 64129595 |
Injection site extravasation | 15.55 | 9.76 | 89 | 368485 | 7997 | 64122161 |
Rhinitis allergic | 15.46 | 9.76 | 14 | 368560 | 8064 | 64122094 |
Post-traumatic stress disorder | 15.41 | 9.76 | 56 | 368518 | 4149 | 64126009 |
Respiratory disorder | 15.39 | 9.76 | 291 | 368283 | 35820 | 64094338 |
Anxiety | 15.34 | 9.76 | 975 | 367599 | 201674 | 63928484 |
Incorrect drug administration rate | 15.30 | 9.76 | 42 | 368532 | 2677 | 64127481 |
Bone pain | 15.27 | 9.76 | 186 | 368388 | 47386 | 64082772 |
Fibromyalgia | 15.25 | 9.76 | 288 | 368286 | 35443 | 64094715 |
Oxygen saturation abnormal | 15.22 | 9.76 | 50 | 368524 | 3521 | 64126637 |
Pain in jaw | 15.20 | 9.76 | 154 | 368420 | 40601 | 64089557 |
Treatment noncompliance | 15.13 | 9.76 | 167 | 368407 | 43315 | 64086843 |
Hallucination | 15.12 | 9.76 | 309 | 368265 | 72479 | 64057679 |
Cells in urine | 15.10 | 9.76 | 11 | 368563 | 188 | 64129970 |
Mitral valve incompetence | 15.00 | 9.76 | 85 | 368489 | 25453 | 64104705 |
Anti-erythrocyte antibody positive | 14.90 | 9.76 | 8 | 368566 | 77 | 64130081 |
Food allergy | 14.83 | 9.76 | 86 | 368488 | 7765 | 64122393 |
Urinary casts | 14.73 | 9.76 | 24 | 368550 | 1058 | 64129100 |
Ventricular tachycardia | 14.71 | 9.76 | 125 | 368449 | 34140 | 64096018 |
Brain scan abnormal | 14.69 | 9.76 | 25 | 368549 | 1143 | 64129015 |
Fungal rhinitis | 14.68 | 9.76 | 7 | 368567 | 51 | 64130107 |
Obesity | 14.62 | 9.76 | 64 | 368510 | 20498 | 64109660 |
Pulmonary hypertension | 14.49 | 9.76 | 167 | 368407 | 42972 | 64087186 |
Gastrooesophageal reflux disease | 14.43 | 9.76 | 363 | 368211 | 82780 | 64047378 |
Eyelid ptosis | 14.41 | 9.76 | 20 | 368554 | 9505 | 64120653 |
Dyslipidaemia | 14.39 | 9.76 | 19 | 368555 | 9223 | 64120935 |
Injection site discolouration | 14.29 | 9.76 | 11 | 368563 | 6864 | 64123294 |
Blood glucose increased | 14.25 | 9.76 | 439 | 368135 | 97634 | 64032524 |
Macular oedema | 14.23 | 9.76 | 5 | 368569 | 4862 | 64125296 |
Skin exfoliation | 14.22 | 9.76 | 176 | 368398 | 44709 | 64085449 |
Diplopia | 14.19 | 9.76 | 92 | 368482 | 26673 | 64103485 |
Chronic kidney disease | 14.17 | 9.76 | 239 | 368335 | 57680 | 64072478 |
Specific gravity urine increased | 14.14 | 9.76 | 15 | 368559 | 431 | 64129727 |
Dependent personality disorder | 14.13 | 9.76 | 9 | 368565 | 122 | 64130036 |
Sinus node dysfunction | 14.09 | 9.76 | 11 | 368563 | 6817 | 64123341 |
Pulmonary arterial hypertension | 14.06 | 9.76 | 86 | 368488 | 25281 | 64104877 |
Actinic keratosis | 13.96 | 9.76 | 6 | 368568 | 5159 | 64124999 |
Drug withdrawal syndrome | 13.96 | 9.76 | 113 | 368461 | 31178 | 64098980 |
Abnormal loss of weight | 13.95 | 9.76 | 13 | 368561 | 7387 | 64122771 |
Swollen tongue | 13.92 | 9.76 | 130 | 368444 | 34824 | 64095334 |
Lipodystrophy acquired | 13.90 | 9.76 | 3 | 368571 | 4024 | 64126134 |
Metastases to liver | 13.89 | 9.76 | 80 | 368494 | 23861 | 64106297 |
Musculoskeletal stiffness | 13.83 | 9.76 | 848 | 367726 | 122358 | 64007800 |
Enthesopathy | 13.83 | 9.76 | 21 | 368553 | 9617 | 64120541 |
Ischaemic stroke | 13.82 | 9.76 | 103 | 368471 | 28932 | 64101226 |
Metastases to lung | 13.81 | 9.76 | 43 | 368531 | 15221 | 64114937 |
Erysipelas | 13.80 | 9.76 | 19 | 368555 | 9062 | 64121096 |
Nocardiosis | 13.77 | 9.76 | 5 | 368569 | 4762 | 64125396 |
Hypoaesthesia | 13.72 | 9.76 | 652 | 367922 | 138456 | 63991702 |
Nasal necrosis | 13.70 | 9.76 | 9 | 368565 | 129 | 64130029 |
Lymphoproliferative disorder | 13.68 | 9.76 | 6 | 368568 | 5097 | 64125061 |
Oesophageal carcinoma | 13.65 | 9.76 | 5 | 368569 | 4738 | 64125420 |
Agranulocytosis | 13.63 | 9.76 | 146 | 368428 | 38083 | 64092075 |
White blood cell count decreased | 13.62 | 9.76 | 750 | 367824 | 157087 | 63973071 |
PCO2 decreased | 13.61 | 9.76 | 42 | 368532 | 2860 | 64127298 |
Aplasia pure red cell | 13.61 | 9.76 | 12 | 368562 | 7002 | 64123156 |
Dysgeusia | 13.61 | 9.76 | 188 | 368386 | 46859 | 64083299 |
Nocturia | 13.59 | 9.76 | 27 | 368547 | 11138 | 64119020 |
Diffuse large B-cell lymphoma | 13.54 | 9.76 | 24 | 368550 | 10337 | 64119821 |
Delusion | 13.47 | 9.76 | 55 | 368519 | 17959 | 64112199 |
Decerebrate posture | 13.43 | 9.76 | 10 | 368564 | 177 | 64129981 |
Leukoencephalopathy | 13.42 | 9.76 | 12 | 368562 | 6955 | 64123203 |
Cytomegalovirus viraemia | 13.34 | 9.76 | 26 | 368548 | 10802 | 64119356 |
Gynaecomastia | 13.32 | 9.76 | 9 | 368565 | 6007 | 64124151 |
Anaphylactic shock | 13.31 | 9.76 | 110 | 368464 | 30218 | 64099940 |
Mydriasis | 13.31 | 9.76 | 140 | 368434 | 15172 | 64114986 |
Skin necrosis | 13.23 | 9.76 | 40 | 368534 | 14289 | 64115869 |
Palpitations | 13.23 | 9.76 | 476 | 368098 | 104012 | 64026146 |
Disturbance in social behaviour | 13.21 | 9.76 | 3 | 368571 | 3884 | 64126274 |
Infusion site urticaria | 13.18 | 9.76 | 17 | 368557 | 604 | 64129554 |
Skin toxicity | 13.17 | 9.76 | 11 | 368563 | 6591 | 64123567 |
Multiple sclerosis relapse | 13.14 | 9.76 | 161 | 368413 | 40974 | 64089184 |
Disorientation | 13.14 | 9.76 | 232 | 368342 | 55596 | 64074562 |
Blood creatine increased | 13.12 | 9.76 | 86 | 368488 | 8106 | 64122052 |
Gait inability | 13.09 | 9.76 | 167 | 368407 | 42201 | 64087957 |
Blood lactic acid increased | 13.07 | 9.76 | 103 | 368471 | 10298 | 64119860 |
Alpha 1 microglobulin increased | 13.07 | 9.76 | 7 | 368567 | 67 | 64130091 |
Pneumonia viral | 13.07 | 9.76 | 83 | 368491 | 7739 | 64122419 |
Monocyte count increased | 13.05 | 9.76 | 85 | 368489 | 7994 | 64122164 |
Blood uric acid decreased | 13.03 | 9.76 | 23 | 368551 | 1083 | 64129075 |
Low density lipoprotein increased | 13.01 | 9.76 | 15 | 368559 | 7725 | 64122433 |
Rhabdomyolysis | 12.98 | 9.76 | 412 | 368162 | 91314 | 64038844 |
Urobilinogen urine increased | 12.95 | 9.76 | 17 | 368557 | 615 | 64129543 |
Epstein-Barr virus infection | 12.91 | 9.76 | 33 | 368541 | 12455 | 64117703 |
Ischaemic cardiomyopathy | 12.91 | 9.76 | 12 | 368562 | 6826 | 64123332 |
Hypertriglyceridaemia | 12.87 | 9.76 | 28 | 368546 | 11177 | 64118981 |
Device leakage | 12.86 | 9.76 | 17 | 368557 | 8249 | 64121909 |
Prescribed underdose | 12.85 | 9.76 | 56 | 368518 | 17959 | 64112199 |
Rebound effect | 12.84 | 9.76 | 6 | 368568 | 4911 | 64125247 |
Arrhythmia | 12.78 | 9.76 | 219 | 368355 | 52725 | 64077433 |
Electrolyte imbalance | 12.76 | 9.76 | 88 | 368486 | 25155 | 64105003 |
Cystitis haemorrhagic | 12.76 | 9.76 | 16 | 368558 | 7940 | 64122218 |
Skin lesion | 12.74 | 9.76 | 140 | 368434 | 36342 | 64093816 |
Hepatitis B reactivation | 12.71 | 9.76 | 6 | 368568 | 4883 | 64125275 |
Neuroleptic malignant syndrome | 12.71 | 9.76 | 87 | 368487 | 24909 | 64105249 |
Brain stem glioma | 12.70 | 9.76 | 9 | 368565 | 147 | 64130011 |
Tricuspid valve incompetence | 12.66 | 9.76 | 52 | 368522 | 16951 | 64113207 |
Mood swings | 12.65 | 9.76 | 54 | 368520 | 17414 | 64112744 |
Abnormal dreams | 12.64 | 9.76 | 25 | 368549 | 10331 | 64119827 |
Acute coronary syndrome | 12.61 | 9.76 | 62 | 368512 | 19248 | 64110910 |
Squamous cell carcinoma | 12.60 | 9.76 | 39 | 368535 | 13830 | 64116328 |
Genital haemorrhage | 12.58 | 9.76 | 8 | 368566 | 5514 | 64124644 |
Partial seizures | 12.46 | 9.76 | 14 | 368560 | 7293 | 64122865 |
Candida infection | 12.44 | 9.76 | 117 | 368457 | 31302 | 64098856 |
Frequent bowel movements | 12.40 | 9.76 | 58 | 368516 | 18247 | 64111911 |
Venoocclusive liver disease | 12.38 | 9.76 | 24 | 368550 | 9991 | 64120167 |
Pulmonary alveolar haemorrhage | 12.33 | 9.76 | 23 | 368551 | 9715 | 64120443 |
Product monitoring error | 12.29 | 9.76 | 8 | 368566 | 5446 | 64124712 |
Therapeutic response decreased | 12.24 | 9.76 | 217 | 368357 | 51971 | 64078187 |
Aggression | 12.24 | 9.76 | 188 | 368386 | 46044 | 64084114 |
Pulmonary tuberculosis | 12.22 | 9.76 | 14 | 368560 | 7230 | 64122928 |
Tendonitis | 12.19 | 9.76 | 67 | 368507 | 20215 | 64109943 |
Bladder cancer | 12.14 | 9.76 | 28 | 368546 | 10946 | 64119212 |
Shock haemorrhagic | 12.10 | 9.76 | 52 | 368522 | 16739 | 64113419 |
Ascites | 12.06 | 9.76 | 266 | 368308 | 61735 | 64068423 |
Bronchopulmonary aspergillosis | 12.05 | 9.76 | 62 | 368512 | 19023 | 64111135 |
Metastases to central nervous system | 12.03 | 9.76 | 40 | 368534 | 13872 | 64116286 |
Metastases to bone | 12.01 | 9.76 | 68 | 368506 | 20367 | 64109791 |
Vitamin K deficiency | 12.00 | 9.76 | 17 | 368557 | 662 | 64129496 |
Anticipatory anxiety | 11.98 | 9.76 | 11 | 368563 | 264 | 64129894 |
Blood loss anaemia | 11.97 | 9.76 | 40 | 368534 | 13852 | 64116306 |
Upper gastrointestinal haemorrhage | 11.96 | 9.76 | 136 | 368438 | 35084 | 64095074 |
Stevens-Johnson syndrome | 11.96 | 9.76 | 268 | 368306 | 33981 | 64096177 |
Activated partial thromboplastin time prolonged | 11.95 | 9.76 | 119 | 368455 | 12712 | 64117446 |
Red cell distribution width decreased | 11.95 | 9.76 | 22 | 368552 | 1071 | 64129087 |
Dyskinesia | 11.90 | 9.76 | 156 | 368418 | 39232 | 64090926 |
Affective disorder | 11.90 | 9.76 | 12 | 368562 | 6568 | 64123590 |
Traumatic liver injury | 11.87 | 9.76 | 15 | 368559 | 522 | 64129636 |
Base excess | 11.86 | 9.76 | 7 | 368567 | 82 | 64130076 |
Pancreatic carcinoma | 11.85 | 9.76 | 26 | 368548 | 10347 | 64119811 |
Infusion site discomfort | 11.83 | 9.76 | 18 | 368556 | 748 | 64129410 |
Lupus-like syndrome | 11.82 | 9.76 | 20 | 368554 | 8771 | 64121387 |
Angiokeratoma | 11.80 | 9.76 | 10 | 368564 | 215 | 64129943 |
Retinal haemorrhage | 11.73 | 9.76 | 15 | 368559 | 7383 | 64122775 |
Skin burning sensation | 11.70 | 9.76 | 27 | 368547 | 10556 | 64119602 |
Large intestine polyp | 11.70 | 9.76 | 28 | 368546 | 10809 | 64119349 |
Obstructive airways disorder | 11.64 | 9.76 | 81 | 368493 | 23104 | 64107054 |
Graft versus host disease in gastrointestinal tract | 11.63 | 9.76 | 9 | 368565 | 5603 | 64124555 |
Fear of injection | 11.61 | 9.76 | 10 | 368564 | 5902 | 64124256 |
Urine oxalate increased | 11.61 | 9.76 | 10 | 368564 | 220 | 64129938 |
Ventricular extrasystoles | 11.61 | 9.76 | 56 | 368518 | 17473 | 64112685 |
Bundle branch block left | 11.59 | 9.76 | 25 | 368549 | 10009 | 64120149 |
Hypothyroidism | 11.58 | 9.76 | 162 | 368412 | 40295 | 64089863 |
Diaphragmatic rupture | 11.57 | 9.76 | 10 | 368564 | 221 | 64129937 |
Encephalopathy | 11.56 | 9.76 | 428 | 368146 | 58391 | 64071767 |
Circulatory collapse | 11.56 | 9.76 | 130 | 368444 | 33602 | 64096556 |
Autonomic dysreflexia | 11.54 | 9.76 | 13 | 368561 | 400 | 64129758 |
Hypoglycaemic coma | 11.49 | 9.76 | 5 | 368569 | 4269 | 64125889 |
Hypersensitivity vasculitis | 11.48 | 9.76 | 13 | 368561 | 6748 | 64123410 |
Stent placement | 11.47 | 9.76 | 9 | 368565 | 5562 | 64124596 |
Retinal deposits | 11.43 | 9.76 | 8 | 368566 | 128 | 64130030 |
Carpal tunnel syndrome | 11.42 | 9.76 | 49 | 368525 | 15779 | 64114379 |
Deafness | 11.39 | 9.76 | 60 | 368514 | 18299 | 64111859 |
Application site pain | 11.38 | 9.76 | 5 | 368569 | 4243 | 64125915 |
Potentiating drug interaction | 11.37 | 9.76 | 17 | 368557 | 7835 | 64122323 |
Cerebral ischaemia | 11.36 | 9.76 | 25 | 368549 | 9937 | 64120221 |
Prothrombin time shortened | 11.35 | 9.76 | 39 | 368535 | 2810 | 64127348 |
Coagulation factor X level decreased | 11.31 | 9.76 | 7 | 368567 | 90 | 64130068 |
Oral pruritus | 11.29 | 9.76 | 29 | 368545 | 1776 | 64128382 |
Vessel puncture site bruise | 11.26 | 9.76 | 13 | 368561 | 411 | 64129747 |
Leukocytosis | 11.26 | 9.76 | 289 | 368285 | 37451 | 64092707 |
Peripheral arterial occlusive disease | 11.26 | 9.76 | 14 | 368560 | 6973 | 64123185 |
Urine ketone body present | 11.25 | 9.76 | 43 | 368531 | 3264 | 64126894 |
Paradoxical drug reaction | 11.25 | 9.76 | 11 | 368563 | 6109 | 64124049 |
Polydipsia | 11.25 | 9.76 | 10 | 368564 | 5811 | 64124347 |
Immunodeficiency | 11.13 | 9.76 | 141 | 368433 | 15983 | 64114175 |
Post procedural pulmonary embolism | 11.06 | 9.76 | 10 | 368564 | 235 | 64129923 |
Intraocular pressure increased | 11.06 | 9.76 | 19 | 368555 | 8283 | 64121875 |
Impaired work ability | 11.05 | 9.76 | 47 | 368527 | 15172 | 64114986 |
Acid-base balance disorder mixed | 11.05 | 9.76 | 7 | 368567 | 94 | 64130064 |
pH urine increased | 11.02 | 9.76 | 13 | 368561 | 421 | 64129737 |
Hernia | 11.01 | 9.76 | 122 | 368452 | 13396 | 64116762 |
Gastritis erosive | 11.00 | 9.76 | 24 | 368550 | 9571 | 64120587 |
Vital capacity decreased | 11.00 | 9.76 | 21 | 368553 | 1051 | 64129107 |
Long QT syndrome | 10.96 | 9.76 | 8 | 368566 | 5131 | 64125027 |
Dystonia | 10.96 | 9.76 | 63 | 368511 | 18802 | 64111356 |
Cardiovascular disorder | 10.95 | 9.76 | 50 | 368524 | 15831 | 64114327 |
Obsessive-compulsive disorder | 10.95 | 9.76 | 7 | 368567 | 4811 | 64125347 |
Flatulence | 10.87 | 9.76 | 141 | 368433 | 35525 | 64094633 |
Antipsychotic drug level increased | 10.86 | 9.76 | 8 | 368566 | 5107 | 64125051 |
Myelocyte percentage increased | 10.85 | 9.76 | 10 | 368564 | 241 | 64129917 |
Ketoacidosis | 10.80 | 9.76 | 14 | 368560 | 6849 | 64123309 |
Emotional distress | 10.79 | 9.76 | 143 | 368431 | 35895 | 64094263 |
Drug level above therapeutic | 10.78 | 9.76 | 72 | 368502 | 6829 | 64123329 |
Acute graft versus host disease in skin | 10.77 | 9.76 | 14 | 368560 | 6841 | 64123317 |
Kidney transplant rejection | 10.73 | 9.76 | 24 | 368550 | 9487 | 64120671 |
Device failure | 10.73 | 9.76 | 10 | 368564 | 5682 | 64124476 |
Hallucination, auditory | 10.71 | 9.76 | 55 | 368519 | 16884 | 64113274 |
Torsade de pointes | 10.63 | 9.76 | 57 | 368517 | 17306 | 64112852 |
Anal fissure | 10.61 | 9.76 | 56 | 368518 | 4880 | 64125278 |
JC virus infection | 10.61 | 9.76 | 3 | 368571 | 3352 | 64126806 |
Drug eruption | 10.59 | 9.76 | 144 | 368430 | 35992 | 64094166 |
Dermatitis | 10.59 | 9.76 | 60 | 368514 | 17969 | 64112189 |
Drug use disorder | 10.59 | 9.76 | 65 | 368509 | 5989 | 64124169 |
Therapy non-responder | 10.57 | 9.76 | 291 | 368283 | 65608 | 64064550 |
Blood bicarbonate decreased | 10.53 | 9.76 | 55 | 368519 | 4774 | 64125384 |
Dysphonia | 10.52 | 9.76 | 194 | 368380 | 46188 | 64083970 |
Oral discomfort | 10.51 | 9.76 | 20 | 368554 | 8386 | 64121772 |
Allergy to plants | 10.49 | 9.76 | 15 | 368559 | 589 | 64129569 |
Tardive dyskinesia | 10.49 | 9.76 | 23 | 368551 | 9155 | 64121003 |
Red blood cell elliptocytes present | 10.45 | 9.76 | 8 | 368566 | 148 | 64130010 |
Balance disorder | 10.44 | 9.76 | 583 | 367991 | 83343 | 64046815 |
Ammonia increased | 10.43 | 9.76 | 72 | 368502 | 6905 | 64123253 |
Eczema | 10.40 | 9.76 | 114 | 368460 | 29606 | 64100552 |
Impaired quality of life | 10.39 | 9.76 | 13 | 368561 | 6458 | 64123700 |
Nephrogenic systemic fibrosis | 10.37 | 9.76 | 11 | 368563 | 5881 | 64124277 |
Necrotising oesophagitis | 10.35 | 9.76 | 16 | 368558 | 674 | 64129484 |
Body height decreased | 10.33 | 9.76 | 17 | 368557 | 7537 | 64122621 |
Administration site swelling | 10.31 | 9.76 | 11 | 368563 | 318 | 64129840 |
Pneumonia cytomegaloviral | 10.28 | 9.76 | 6 | 368568 | 4333 | 64125825 |
Inflammation | 10.27 | 9.76 | 464 | 368110 | 64836 | 64065322 |
Sensitivity to weather change | 10.25 | 9.76 | 14 | 368560 | 6700 | 64123458 |
Human herpesvirus 6 infection | 10.25 | 9.76 | 7 | 368567 | 4647 | 64125511 |
Nail bed inflammation | 10.24 | 9.76 | 14 | 368560 | 527 | 64129631 |
Coeliac disease | 10.21 | 9.76 | 75 | 368499 | 7337 | 64122821 |
Spinal operation | 10.19 | 9.76 | 12 | 368562 | 6121 | 64124037 |
Carbon monoxide poisoning | 10.17 | 9.76 | 10 | 368564 | 262 | 64129896 |
Band neutrophil percentage increased | 10.14 | 9.76 | 12 | 368562 | 390 | 64129768 |
Nose deformity | 10.14 | 9.76 | 8 | 368566 | 155 | 64130003 |
Uterine perforation | 10.09 | 9.76 | 11 | 368563 | 5809 | 64124349 |
Failure to suspend medication | 10.06 | 9.76 | 12 | 368562 | 393 | 64129765 |
Malignant melanoma | 10.06 | 9.76 | 39 | 368535 | 12925 | 64117233 |
Melaena | 10.06 | 9.76 | 231 | 368343 | 53317 | 64076841 |
Intestinal haemorrhage | 10.03 | 9.76 | 10 | 368564 | 5504 | 64124654 |
Adenocarcinoma of colon | 10.01 | 9.76 | 8 | 368566 | 4900 | 64125258 |
Limb discomfort | 10.01 | 9.76 | 103 | 368471 | 27072 | 64103086 |
Renal disorder | 9.99 | 9.76 | 142 | 368432 | 35223 | 64094935 |
Ductus arteriosus stenosis foetal | 9.97 | 9.76 | 6 | 368568 | 73 | 64130085 |
Hepatic cancer | 9.96 | 9.76 | 17 | 368557 | 7431 | 64122727 |
Cerebral artery thrombosis | 9.96 | 9.76 | 20 | 368554 | 1039 | 64129119 |
Aortic valve stenosis | 9.94 | 9.76 | 7 | 368567 | 4573 | 64125585 |
Respiratory tract congestion | 9.93 | 9.76 | 53 | 368521 | 16112 | 64114046 |
Product complaint | 9.91 | 9.76 | 35 | 368539 | 11919 | 64118239 |
Pulmonary fibrosis | 9.90 | 9.76 | 116 | 368458 | 29762 | 64100396 |
Pharyngitis streptococcal | 9.90 | 9.76 | 84 | 368490 | 8584 | 64121574 |
Chronic gastrointestinal bleeding | 9.88 | 9.76 | 12 | 368562 | 401 | 64129757 |
BK virus infection | 9.84 | 9.76 | 17 | 368557 | 7395 | 64122763 |
Thoracic vertebral fracture | 9.83 | 9.76 | 7 | 368567 | 4546 | 64125612 |
Dysstasia | 9.83 | 9.76 | 85 | 368489 | 23130 | 64107028 |
Respiratory failure | 9.83 | 9.76 | 790 | 367784 | 160393 | 63969765 |
Magnesium deficiency | 9.81 | 9.76 | 14 | 368560 | 549 | 64129609 |
Sudden infant death syndrome | 9.80 | 9.76 | 8 | 368566 | 163 | 64129995 |
Laboratory test abnormal | 9.79 | 9.76 | 89 | 368485 | 23974 | 64106184 |
Dermatitis acneiform | 9.78 | 9.76 | 21 | 368553 | 8422 | 64121736 |
None
Source | Code | Description |
---|---|---|
ATC | R06AA09 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
ATC | R06AA59 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
FDA MoA | N0000000207 | Histamine Receptor Antagonists |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
FDA EPC | N0000175750 | Antihistamine |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:37956 | antihistamines |
CHEBI has role | CHEBI:48873 | acetylcholine receptor antagonist |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:51177 | anti-tussive |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Dermatographic urticaria | indication | 7632005 | DOID:743 |
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Sneezing | indication | 76067001 | |
Common cold | indication | 82272006 | DOID:10459 |
Urticaria | indication | 126485001 | |
Influenza-like symptoms | indication | 315642008 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Itching of skin | indication | 418363000 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Morning sickness | off-label use | 51885006 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Ventricular tachycardia | contraindication | 25569003 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Acidosis | contraindication | 51387008 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Hepatic failure | contraindication | 59927004 | |
Arterial thrombosis | contraindication | 65198009 | |
Poisoning by acetaminophen | contraindication | 70273001 | |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Partial atrioventricular block | contraindication | 195039008 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Disorder of coronary artery | contraindication | 414024009 | |
Hypertensive urgency | contraindication | 443482000 |
Species | Use | Relation |
---|---|---|
Cats | Antihistaminic therapy | Indication |
Dogs | Antihistaminic therapy | Indication |
Horses | Antihistaminic therapy | Indication |
Product | Applicant | Ingredients |
---|---|---|
A-H-Tablets 100 mg, A-H-Tablets 25 mg | Intervet Inc. | 1 |
A-H Injection | Intervet Inc. | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.83 | Basic |
pKa2 | 4.29 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
20MG;20MG | BONJESTA | DUCHESNAY | N209661 | Nov. 7, 2016 | RX | TABLET, EXTENDED RELEASE | ORAL | 9089489 | Feb. 18, 2033 | TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT |
20MG;20MG | BONJESTA | DUCHESNAY | N209661 | Nov. 7, 2016 | RX | TABLET, EXTENDED RELEASE | ORAL | 9375404 | Feb. 18, 2033 | TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT |
20MG;20MG | BONJESTA | DUCHESNAY | N209661 | Nov. 7, 2016 | RX | TABLET, EXTENDED RELEASE | ORAL | 9526703 | Feb. 18, 2033 | TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT |
20MG;20MG | BONJESTA | DUCHESNAY | N209661 | Nov. 7, 2016 | RX | TABLET, EXTENDED RELEASE | ORAL | 9937132 | Feb. 18, 2033 | TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
4019738 | VUID |
N0000147830 | NUI |
D02327 | KEGG_DRUG |
562-10-7 | SECONDARY_CAS_RN |
4019049 | VANDF |
4019738 | VANDF |
C0013092 | UMLSCUI |
CHEBI:51380 | CHEBI |
CHEMBL1004 | ChEMBL_ID |
CHEMBL1200392 | ChEMBL_ID |
DB00366 | DRUGBANK_ID |
D004319 | MESH_DESCRIPTOR_UI |
C035385 | MESH_SUPPLEMENTAL_RECORD_UI |
3162 | PUBCHEM_CID |
7171 | IUPHAR_LIGAND_ID |
1782 | INN_ID |
95QB77JKPL | UNII |
23665 | RXNORM |
10000 | MMSL |
4644 | MMSL |
d03154 | MMSL |
003372 | NDDF |
004789 | NDDF |
412380009 | SNOMEDCT_US |
44068004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Robitussin Maximum Strength Nighttime Cough DM | HUMAN OTC DRUG LABEL | 2 | 0031-8718 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime | HUMAN OTC DRUG LABEL | 3 | 0031-8744 | CAPSULE, LIQUID FILLED | 6.25 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
Robitussin Honey Maximum Strength Nighttime Cough DM | HUMAN OTC DRUG LABEL | 2 | 0031-8758 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 17 sections |
Childrens Robitussin Honey Nighttime Cough DM | HUMAN OTC DRUG LABEL | 2 | 0031-8762 | SOLUTION | 6.25 mg | ORAL | OTC monograph final | 17 sections |
Good Sense Severe NightTime | HUMAN OTC DRUG LABEL | 4 | 0113-0019 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Good Sense Severe NightTime | HUMAN OTC DRUG LABEL | 4 | 0113-0019 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
good sense night time | HUMAN OTC DRUG LABEL | 3 | 0113-0056 | CAPSULE, LIQUID FILLED | 6.25 mg | ORAL | OTC monograph final | 15 sections |
good sense night time | HUMAN OTC DRUG LABEL | 3 | 0113-0335 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Good sense sleep aid | HUMAN OTC DRUG LABEL | 1 | 0113-0441 | TABLET | 25 mg | ORAL | ANDA | 16 sections |
good sense nighttime | HUMAN OTC DRUG LABEL | 3 | 0113-0459 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Good Sense Nighttime Cough | HUMAN OTC DRUG LABEL | 2 | 0113-0668 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Good Sense Severe NightTime Cold and Flu | HUMAN OTC DRUG LABEL | 4 | 0113-0763 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Good Sense Severe NightTime Cold and Flu | HUMAN OTC DRUG LABEL | 4 | 0113-0763 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Basic Care Nighttime Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 0113-7056 | CAPSULE, LIQUID FILLED | 6.25 mg | ORAL | OTC monograph final | 16 sections |
basic care nighttime cold and flu | HUMAN OTC DRUG LABEL | 3 | 0113-7335 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
basic care sleep aid | HUMAN OTC DRUG LABEL | 1 | 0113-7441 | TABLET | 25 mg | ORAL | ANDA | 16 sections |
Basic Care Nighttime | HUMAN OTC DRUG LABEL | 3 | 0113-7459 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
basic care nighttime cold and flu | HUMAN OTC DRUG LABEL | 4 | 0113-7501 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
basic care nighttime cold and flu severe | HUMAN OTC DRUG LABEL | 4 | 0113-7763 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night | HUMAN OTC DRUG LABEL | 4 | 0280-0021 | TABLET, EFFERVESCENT | 6.25 mg | ORAL | OTC monograph final | 16 sections |
Alka-Seltzer Plus Severe Cold Night PowerFast Fizz | HUMAN OTC DRUG LABEL | 4 | 0280-0068 | TABLET, EFFERVESCENT | 6.25 mg | ORAL | OTC monograph final | 16 sections |
Alka-Seltzer Plus Night Severe Cold and Flu | HUMAN OTC DRUG LABEL | 4 | 0280-0922 | POWDER, FOR SOLUTION | 12.50 mg | ORAL | OTC monograph final | 17 sections |
Alka-Seltzer Plus Cold Night | HUMAN OTC DRUG LABEL | 4 | 0280-1545 | TABLET, EFFERVESCENT | 6.25 mg | ORAL | OTC monograph final | 17 sections |
Alka-Seltzer Plus Maximum Strength Night Cold and Flu | HUMAN OTC DRUG LABEL | 4 | 0280-1600 | CAPSULE, LIQUID FILLED | 6.25 mg | ORAL | OTC monograph final | 17 sections |
Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough | HUMAN OTC DRUG LABEL | 4 | 0280-1620 | CAPSULE, LIQUID FILLED | 6.25 mg | ORAL | OTC monograph final | 17 sections |
Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels | HUMAN OTC DRUG LABEL | 4 | 0280-1640 | CAPSULE, LIQUID FILLED | 6.25 mg | ORAL | OTC monograph final | 17 sections |
SafetussinPM | HUMAN OTC DRUG LABEL | 2 | 0295-5307 | LIQUID | 3.13 mg | ORAL | OTC monograph final | 13 sections |
Cough | HUMAN OTC DRUG LABEL | 2 | 0363-0019 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Night Time Severe Cold and Flu | HUMAN OTC DRUG LABEL | 4 | 0363-0331 | LIQUID | 12.50 mg | ORAL | OTC monograph final | 16 sections |
Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 0363-0401 | SOLUTION | 12.50 mg | ORAL | OTC monograph final | 16 sections |