doxylamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
962 469-21-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxylamine
  • (+/-)-Doxylamine
  • doxylamine succinate
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.
  • Molecular weight: 270.38
  • Formula: C17H22N2O
  • CLOGP: 2.35
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 25.36
  • ALOGS: -2.70
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 24.70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Bocci G, Oprea TI, Benet LZ
fu (Fraction unbound in plasma) 0.51 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
April 7, 1948 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2319.47 10.11 5447 466901 241803 62774871
Completed suicide 2292.59 10.11 3982 468366 141691 62874983
Infusion related reaction 962.21 10.11 3994 468354 241527 62775147
Exposure to toxic agent 907.12 10.11 548 471800 5039 63011635
Sinusitis 669.45 10.11 3394 468954 223259 62793415
Muscle injury 610.77 10.11 1440 470908 63905 62952769
Folliculitis 594.72 10.11 1491 470857 68826 62947848
Acute hepatic failure 533.33 10.11 670 471678 17657 62999017
Irritable bowel syndrome 527.86 10.11 1578 470770 80834 62935840
Lower respiratory tract infection 521.76 10.11 2158 470190 130149 62886525
Blood pressure fluctuation 453.91 10.11 1040 471308 45277 62971397
Intentional overdose 452.48 10.11 1396 470952 72756 62943918
Blister 441.24 10.11 2025 470323 127789 62888885
Duodenal ulcer perforation 421.06 10.11 1517 470831 85692 62930982
Helicobacter infection 418.63 10.11 1579 470769 91206 62925468
Sleep disorder due to general medical condition, insomnia type 416.33 10.11 1083 471265 51134 62965540
Ill-defined disorder 403.12 10.11 1432 470916 80323 62936351
Overdose 393.91 10.11 1799 470549 113279 62903395
Pericarditis 387.65 10.11 1970 470378 129609 62887065
Anti-cyclic citrullinated peptide antibody positive 386.16 10.11 1801 470547 114411 62902263
Injection site pain 363.75 10.11 261 472087 129539 62887135
Impaired healing 357.61 10.11 1612 470736 100930 62915744
Rheumatoid arthritis 348.29 10.11 3143 469205 250676 62765998
Hepatic enzyme increased 345.29 10.11 2632 469716 199696 62816978
Intentional product misuse 329.03 10.11 1100 471248 59817 62956857
Metabolic acidosis 325.25 10.11 901 471447 44168 62972506
Nasopharyngitis 324.97 10.11 3101 469247 251156 62765518
Product dose omission issue 321.86 10.11 799 471549 233514 62783160
Hepatic cytolysis 306.55 10.11 469 471879 14938 63001736
Joint swelling 287.92 10.11 3711 468637 323955 62692719
Therapeutic product effect decreased 271.36 10.11 2405 469943 190782 62825892
Synovitis 255.36 10.11 2313 470035 184605 62832069
Intentional product use issue 250.44 10.11 1720 470628 126172 62890502
Gastrointestinal disorder 242.92 10.11 1741 470607 129498 62887176
Analgesic drug level increased 239.58 10.11 173 472175 2199 63014475
Diarrhoea 239.44 10.11 3815 468533 711551 62305123
Hepatotoxicity 224.59 10.11 696 471652 36345 62980329
Hand deformity 223.79 10.11 1985 470363 157472 62859202
Stomatitis 220.11 10.11 1775 470573 136950 62879724
Device expulsion 217.31 10.11 10 472338 34912 62981762
Discomfort 216.38 10.11 2047 470301 165327 62851347
Hypersensitivity 215.57 10.11 3213 469135 289472 62727202
Injection site erythema 215.50 10.11 181 472167 82993 62933681
Anion gap 213.33 10.11 129 472219 1188 63015486
Medication error 210.74 10.11 859 471489 51425 62965249
Weight increased 205.92 10.11 2898 469450 257894 62758780
Wrong technique in product usage process 195.65 10.11 110 472238 62230 62954444
Swelling 193.09 10.11 2998 469350 272380 62744294
Wound 192.12 10.11 1958 470390 161305 62855369
Psoriasis 188.76 10.11 221 472127 86736 62929938
Body temperature increased 186.26 10.11 655 471693 36537 62980137
Depressed level of consciousness 175.39 10.11 919 471429 61159 62955515
Anaemia 168.53 10.11 1385 470963 292045 62724629
Suicide attempt 164.03 10.11 890 471458 60028 62956646
Sedation complication 158.83 10.11 331 472017 13491 63003183
Blood pressure systolic abnormal 149.68 10.11 317 472031 13069 63003605
Rheumatoid factor positive 147.66 10.11 1105 471243 83301 62933373
Blood pressure diastolic abnormal 147.38 10.11 331 472017 14211 63002463
Cardiac failure congestive 145.73 10.11 292 472056 92141 62924533
Heart rate decreased 144.57 10.11 697 471651 44863 62971811
Infusion site pain 143.87 10.11 359 471989 16510 63000164
Rheumatic fever 143.69 10.11 669 471679 42442 62974232
Drug ineffective 141.38 10.11 6349 465999 1038416 61978258
Injection site reaction 138.94 10.11 138 472210 58386 62958288
Peripheral swelling 137.91 10.11 2760 469588 263182 62753492
Creatinine renal clearance decreased 134.84 10.11 343 472005 15965 63000709
Infection 130.58 10.11 2413 469935 226760 62789914
Poisoning deliberate 130.49 10.11 270 472078 10948 63005726
Confusional state 128.87 10.11 2472 469876 233908 62782766
Injection site bruising 128.58 10.11 76 472272 41834 62974840
Coagulopathy 128.23 10.11 390 471958 20154 62996520
Blood pressure diastolic decreased 127.90 10.11 416 471932 22290 62994384
Blood pressure systolic increased 122.59 10.11 685 471663 46712 62969962
Injection site pruritus 119.55 10.11 96 472252 45020 62971654
Infusion site swelling 118.20 10.11 239 472109 9531 63007143
Disease progression 117.14 10.11 492 471856 122266 62894408
Infusion site extravasation 116.68 10.11 247 472101 10179 63006495
Ear pain 115.63 10.11 554 471794 35564 62981110
Swollen joint count increased 114.69 10.11 552 471796 35502 62981172
Glossodynia 112.01 10.11 1912 470436 176964 62839710
Drug hypersensitivity 111.90 10.11 1632 470716 309055 62707619
Neutropenia 111.18 10.11 803 471545 174202 62842472
Myocardial infarction 105.11 10.11 385 471963 99508 62917166
Throat irritation 104.03 10.11 554 471794 37093 62979581
Malignant neoplasm progression 103.49 10.11 292 472056 81829 62934845
Muscle spasticity 103.29 10.11 377 471971 21417 62995257
Blood calcium decreased 101.40 10.11 428 471920 26023 62990651
Blood pressure increased 99.90 10.11 1728 470620 160334 62856340
Hospitalisation 99.67 10.11 313 472035 84768 62931906
Pemphigus 98.59 10.11 1917 470431 181809 62834865
Nausea 98.51 10.11 5278 467070 849193 62167481
Therapy cessation 98.09 10.11 52 472296 30405 62986269
Injection site swelling 96.82 10.11 127 472221 47445 62969229
Dizziness 96.23 10.11 2449 469899 427476 62589198
Cardiac failure 96.15 10.11 340 472008 88802 62927872
Respiratory arrest 94.75 10.11 487 471861 32158 62984516
Arthropathy 94.56 10.11 2351 469997 232441 62784233
Neuropathy peripheral 93.96 10.11 480 471868 113187 62903487
Oxygen saturation decreased 92.71 10.11 1038 471310 87547 62929127
Feeling abnormal 92.26 10.11 685 471663 147707 62868967
Product quality issue 91.71 10.11 79 472269 35786 62980888
Pyroglutamic acidosis 89.68 10.11 57 472291 578 63016096
Hepatic failure 89.35 10.11 511 471837 35145 62981529
Osteonecrosis of jaw 89.04 10.11 78 472270 35045 62981629
White blood cell count decreased 87.97 10.11 639 471709 138465 62878209
Mobility decreased 87.00 10.11 1325 471023 119834 62896840
Infusion site pruritus 86.97 10.11 159 472189 5876 63010798
Infusion site erythema 86.72 10.11 236 472112 11443 63005231
Drug resistance 85.08 10.11 32 472316 22901 62993773
Coma 84.46 10.11 790 471558 63574 62953100
Respiratory depression 84.32 10.11 259 472089 13456 63003218
Cardio-respiratory arrest 84.30 10.11 747 471601 59212 62957462
Contraindicated product administered 84.28 10.11 2168 470180 215480 62801194
Product substitution issue 84.25 10.11 10 472338 15986 63000688
Pruritus 80.89 10.11 3373 468975 358080 62658594
Acute lung injury 79.86 10.11 77 472271 1494 63015180
Pancytopenia 79.74 10.11 410 471938 96523 62920151
Decreased appetite 79.14 10.11 1352 470996 249700 62766974
Muscle spasms 78.97 10.11 761 471587 155389 62861285
Cerebrovascular accident 77.95 10.11 477 471871 107547 62909127
Unevaluable event 76.21 10.11 168 472180 51218 62965456
Device dislocation 75.54 10.11 49 472299 25656 62991018
Poisoning 75.36 10.11 249 472099 13451 63003223
Hepatic necrosis 74.69 10.11 144 472204 5543 63011131
Poor venous access 74.54 10.11 261 472087 14524 63002150
Diabetes mellitus 74.41 10.11 193 472155 55617 62961057
Orthostatic hypotension 74.09 10.11 492 471856 35668 62981006
Suspected suicide 73.96 10.11 156 472192 6412 63010262
Pyrexia 73.95 10.11 4241 468107 466237 62550437
Drug interaction 73.17 10.11 1231 471117 227900 62788774
COVID-19 72.95 10.11 1215 471133 111888 62904786
Product storage error 72.56 10.11 12 472336 14944 63001730
Therapeutic product effect incomplete 71.33 10.11 591 471757 124465 62892209
Device malfunction 71.31 10.11 22 472326 17835 62998839
Bone marrow failure 70.75 10.11 68 472280 29222 62987452
Contusion 70.72 10.11 1536 470812 148508 62868166
Paraesthesia 69.97 10.11 788 471560 156178 62860496
Surgery 69.92 10.11 99 472249 35813 62980861
Sopor 69.69 10.11 39 472309 22125 62994549
Depression 69.32 10.11 1036 471312 195456 62821218
Systemic lupus erythematosus 68.73 10.11 2038 470310 206880 62809794
Night sweats 68.54 10.11 608 471740 48206 62968468
No adverse event 67.67 10.11 128 472220 41277 62975397
Cognitive disorder 67.29 10.11 673 471675 55142 62961532
Blood cholesterol increased 66.98 10.11 1027 471321 93005 62923669
Drug intolerance 66.45 10.11 2869 469479 305792 62710882
Vision blurred 65.75 10.11 407 471941 91517 62925157
Arthralgia 65.59 10.11 5002 467346 564708 62451966
Renal impairment 64.87 10.11 388 471960 87967 62928707
Bone pain 64.70 10.11 200 472148 54441 62962233
Neoplasm progression 64.61 10.11 107 472241 36321 62980353
Injection site warmth 63.85 10.11 17 472331 15178 63001496
Abortion spontaneous 63.85 10.11 162 472186 47033 62969641
Palmar-plantar erythrodysaesthesia syndrome 63.48 10.11 47 472301 22968 62993706
Sedation 63.33 10.11 500 471848 38309 62978365
Pyroglutamate increased 63.31 10.11 40 472308 401 63016273
Type 2 diabetes mellitus 62.17 10.11 738 471610 63130 62953544
Electric shock 60.23 10.11 61 472287 1259 63015415
Seizure 59.44 10.11 665 471683 131969 62884705
Injection site rash 59.27 10.11 33 472315 18776 62997898
Dehydration 58.75 10.11 921 471427 172433 62844241
Exposure via ingestion 58.49 10.11 89 472259 2820 63013854
Interstitial lung disease 58.49 10.11 249 472099 61659 62955015
Oedema peripheral 57.95 10.11 1026 471322 188485 62828189
Infusion site bruising 57.82 10.11 103 472245 3729 63012945
Ear pruritus 57.81 10.11 105 472243 3860 63012814
Platelet count decreased 57.40 10.11 569 471779 115553 62901121
Epistaxis 56.80 10.11 313 472035 72412 62944262
Infusion site haemorrhage 56.34 10.11 120 472228 4966 63011708
Accidental overdose 55.76 10.11 330 472018 22979 62993695
Anion gap abnormal 55.43 10.11 36 472312 380 63016294
Liver injury 54.86 10.11 690 471658 59830 62956844
Visual acuity reduced 54.69 10.11 49 472299 21777 62994897
Drug use disorder 54.53 10.11 117 472231 4867 63011807
Device difficult to use 54.37 10.11 14 472334 12782 63003892
Loss of consciousness 54.21 10.11 589 471759 117532 62899142
Drug abuse 53.95 10.11 798 471550 71720 62944954
Gastrointestinal haemorrhage 52.71 10.11 370 471978 80806 62935868
Renal failure 52.67 10.11 590 471758 117062 62899612
Thrombocytopenia 52.59 10.11 799 471549 150358 62866316
Red blood cell sedimentation rate abnormal 52.52 10.11 42 472306 19740 62996934
Injection site haemorrhage 52.52 10.11 62 472286 24252 62992422
Respiratory failure 52.07 10.11 495 471853 101363 62915311
Heart rate increased 51.41 10.11 986 471362 93252 62923422
Full blood count decreased 51.40 10.11 71 472277 25953 62990721
Therapy interrupted 50.73 10.11 103 472245 32352 62984322
Tremor 50.21 10.11 687 471661 131552 62885122
Heart rate irregular 50.19 10.11 312 472036 22109 62994565
Hyperkalaemia 49.99 10.11 220 472128 53983 62962691
Injection site urticaria 49.97 10.11 21 472327 14052 63002622
Hypokalaemia 49.91 10.11 512 471836 103292 62913382
Blood pressure diastolic increased 49.85 10.11 176 472172 9834 63006840
Suicidal ideation 49.66 10.11 267 472081 62154 62954520
Jaundice cholestatic 49.47 10.11 143 472205 7181 63009493
Dyspnoea exertional 49.05 10.11 256 472092 60046 62956628
Schizoaffective disorder 49.01 10.11 92 472256 3470 63013204
Hyperlipidaemia 48.96 10.11 44 472304 19527 62997147
Device issue 48.89 10.11 63 472285 23718 62992956
Multiple sclerosis relapse 48.28 10.11 191 472157 48287 62968387
Hyponatraemia 48.20 10.11 566 471782 111334 62905340
Underdose 47.44 10.11 82 472266 27374 62989300
Posterior reversible encephalopathy syndrome 47.09 10.11 36 472312 17309 62999365
Transient ischaemic attack 46.99 10.11 135 472213 37618 62979056
Respiratory disorder 46.98 10.11 471 471877 38611 62978063
Atrial fibrillation 46.81 10.11 599 471749 116037 62900637
Full blood count abnormal 46.78 10.11 104 472244 31613 62985061
Urine leukocyte esterase positive 46.24 10.11 90 472258 3489 63013185
Hypomania 46.09 10.11 127 472221 6203 63010471
Gastrooesophageal reflux disease 45.87 10.11 472 471876 95167 62921507
Dry skin 45.44 10.11 243 472105 56644 62960030
Accidental exposure to product 45.42 10.11 84 472264 27321 62989353
Myelodysplastic syndrome 45.20 10.11 35 472313 16719 62999955
Hypotension 45.19 10.11 2470 469878 270134 62746540
Blood parathyroid hormone decreased 45.03 10.11 9 472339 9782 63006892
Myalgia 44.56 10.11 794 471554 145735 62870939
Injection site mass 44.26 10.11 44 472304 18612 62998062
Leukopenia 44.17 10.11 365 471983 76925 62939749
Inappropriate schedule of product administration 43.57 10.11 1047 471301 102918 62913756
Body temperature decreased 43.16 10.11 279 472069 20040 62996634
Coronary artery disease 43.13 10.11 112 472236 32265 62984409
Therapeutic response unexpected 42.52 10.11 46 472302 18713 62997961
Memory impairment 42.37 10.11 534 471814 103724 62912950
Incorrect drug administration rate 42.19 10.11 92 472256 3870 63012804
Rash pruritic 42.11 10.11 266 472082 59533 62957141
Drug withdrawal syndrome 41.91 10.11 87 472261 27107 62989567
Urine abnormality 41.71 10.11 131 472217 6888 63009786
Hypocalcaemia 41.26 10.11 111 472237 31602 62985072
Crystal urine present 41.17 10.11 56 472292 1598 63015076
Cytokine release syndrome 41.16 10.11 213 472135 14101 63002573
Drug-induced liver injury 41.02 10.11 469 471879 39753 62976921
Syncope 40.99 10.11 620 471728 116765 62899909
Product prescribing error 40.60 10.11 84 472264 26205 62990469
Granuloma skin 40.42 10.11 7 472341 8430 63008244
Prothrombin time shortened 40.06 10.11 61 472287 1934 63014740
Myelosuppression 39.86 10.11 72 472276 23631 62993043
Breast cancer stage I 39.74 10.11 3 472345 6886 63009788
Pulmonary hypertension 39.74 10.11 142 472206 36981 62979693
Pain in extremity 39.35 10.11 2040 470308 329446 62687228
Weight fluctuation 39.29 10.11 161 472187 9658 63007016
Blood glucose increased 39.08 10.11 416 471932 83340 62933334
White blood cells urine positive 39.07 10.11 105 472243 5053 63011621
Fluid retention 38.77 10.11 272 472076 59414 62957260
Basal cell carcinoma 38.70 10.11 95 472253 27896 62988778
Skin necrosis 37.82 10.11 29 472319 13921 63002753
Macular degeneration 37.57 10.11 310 472038 24066 62992608
Fall 37.50 10.11 2465 469883 389869 62626805
Rash 37.13 10.11 4739 467609 556132 62460542
Respiratory rate increased 37.12 10.11 200 472148 13448 63003226
Septic shock 37.02 10.11 317 472031 66312 62950362
Breast cancer female 37.00 10.11 28 472320 13531 63003143
Hypothyroidism 36.95 10.11 177 472171 42455 62974219
Breast cancer 36.82 10.11 210 472138 48173 62968501
Anticipatory anxiety 36.81 10.11 46 472302 1205 63015469
Administration site swelling 36.78 10.11 47 472301 1260 63015414
Hypercalcaemia 36.19 10.11 100 472248 28222 62988452
Injection site induration 35.72 10.11 12 472336 9214 63007460
Mucosal inflammation 35.01 10.11 205 472143 46723 62969951
Haematotoxicity 34.92 10.11 13 472335 9363 63007311
Osteonecrosis 34.91 10.11 82 472266 24448 62992226
Burning sensation 34.33 10.11 250 472098 54157 62962517
Palpitations 34.30 10.11 611 471737 112159 62904515
Therapeutic response decreased 34.05 10.11 293 472055 61232 62955442
Dysgeusia 33.81 10.11 206 472142 46504 62970170
Multiple drug therapy 33.65 10.11 80 472268 3566 63013108
Alanine aminotransferase increased 33.46 10.11 1010 471338 102760 62913914
Metastases to bone 33.45 10.11 66 472282 20953 62995721
Spinal stenosis 33.38 10.11 37 472311 14888 63001786
Genital haemorrhage 33.18 10.11 7 472341 7325 63009349
Haemorrhage 33.15 10.11 292 472056 60730 62955944
Panniculitis 33.05 10.11 22 472326 11363 63005311
Femur fracture 32.99 10.11 179 472169 41577 62975097
Urinary sediment present 32.96 10.11 59 472289 2144 63014530
Pulmonary embolism 32.76 10.11 641 471707 116043 62900631
Acute myocardial infarction 32.35 10.11 126 472222 31998 62984676
Cardiac disorder 32.31 10.11 233 472115 50583 62966091
Vaginal haemorrhage 32.26 10.11 101 472247 27386 62989288
Hypertensive crisis 31.94 10.11 40 472308 15246 63001428
Extrapyramidal disorder 31.89 10.11 31 472317 13253 63003421
Device use error 31.89 10.11 3 472345 5758 63010916
Skin exfoliation 31.77 10.11 189 472159 42913 62973761
Facet joint syndrome 31.76 10.11 176 472172 11962 63004712
Fibromyalgia 31.63 10.11 803 471545 79617 62937057
Urticaria 31.46 10.11 1522 470826 164280 62852394
Ascites 31.41 10.11 176 472172 40552 62976122
Diabetic ketoacidosis 31.26 10.11 66 472282 20439 62996235
Deep vein thrombosis 31.21 10.11 437 471911 83363 62933311
Administration site pain 31.08 10.11 35 472313 819 63015855
Pulmonary arterial hypertension 30.92 10.11 77 472271 22500 62994174
Blood potassium decreased 30.60 10.11 185 472163 41841 62974833
Chronic kidney disease 30.41 10.11 205 472143 45193 62971481
International normalised ratio increased 30.38 10.11 500 471848 45925 62970749
Thinking abnormal 30.31 10.11 21 472327 10622 63006052
Irritability 30.23 10.11 127 472221 31567 62985107
Carpal tunnel syndrome 30.10 10.11 69 472279 20748 62995926
Intervertebral discitis 29.98 10.11 71 472277 3157 63013517
Acute kidney injury 29.75 10.11 1629 470719 261786 62754888
Lymphocyte count decreased 29.60 10.11 350 471998 29907 62986767
Soft tissue disorder 29.54 10.11 86 472262 4336 63012338
Sleep apnoea syndrome 29.51 10.11 114 472234 29019 62987655
Epilepsy 29.32 10.11 103 472245 26962 62989712
Bursitis 29.28 10.11 412 471936 36629 62980045
Infusion site mass 29.19 10.11 54 472294 2014 63014660
Pathogen resistance 29.18 10.11 6 472342 6392 63010282
Asthma 29.14 10.11 724 471624 126837 62889837
Right ventricular failure 29.09 10.11 52 472296 17136 62999538
Gestational diabetes 29.06 10.11 13 472335 8383 63008291
Cytomegalovirus infection 29.05 10.11 71 472277 20881 62995793
Injection site discolouration 29.03 10.11 11 472337 7837 63008837
Sepsis 28.83 10.11 893 471455 152230 62864444
Neutrophil percentage increased 28.72 10.11 66 472282 2877 63013797
Cerebral infarction 28.61 10.11 87 472261 23806 62992868
Ageusia 28.60 10.11 36 472312 13692 63002982
Anxiety 28.47 10.11 1325 471023 216216 62800458
Metastases to liver 28.36 10.11 86 472262 23553 62993121
Dyspnoea 28.35 10.11 4404 467944 656909 62359765
Neurotoxicity 28.22 10.11 52 472296 16938 62999736
Red blood cells urine positive 28.22 10.11 68 472280 3058 63013616
Complication associated with device 28.17 10.11 52 472296 16926 62999748
Heavy menstrual bleeding 28.12 10.11 56 472292 17717 62998957
Foetal exposure during pregnancy 28.11 10.11 132 472216 31830 62984844
Metastases to lung 28.09 10.11 32 472316 12718 63003956
Electrolyte imbalance 27.86 10.11 68 472280 20008 62996666
Infusion site nodule 27.70 10.11 44 472304 1448 63015226
Hyperglycaemia 27.58 10.11 190 472158 41677 62974997
Hepatitis acute 27.12 10.11 137 472211 8983 63007691
Sensitivity to weather change 27.01 10.11 10 472338 7227 63009447
Thrombosis 26.93 10.11 330 472018 64425 62952249
Specific gravity urine decreased 26.68 10.11 31 472317 751 63015923
Dermatitis atopic 26.63 10.11 20 472328 9704 63006970
Hepatic encephalopathy 26.52 10.11 159 472189 11123 63005551
Forced expiratory volume decreased 26.43 10.11 3 472345 4965 63011709
Injury 26.39 10.11 723 471625 72524 62944150
Anion gap increased 26.38 10.11 49 472299 1833 63014841
Disturbance in attention 26.31 10.11 171 472177 38018 62978656
Disease recurrence 26.31 10.11 113 472235 27917 62988757
Pneumocystis jirovecii pneumonia 26.16 10.11 54 472294 16860 62999814
Brain oedema 26.04 10.11 188 472160 14007 63002667
Withdrawal syndrome 26.01 10.11 70 472278 19927 62996747
Lymphocyte percentage decreased 25.95 10.11 64 472284 2921 63013753
Deep vein thrombosis postoperative 25.95 10.11 159 472189 11210 63005464
Laboratory test abnormal 25.56 10.11 108 472240 26804 62989870
Abdominal distension 25.48 10.11 472 471876 86143 62930531
Infusion site irritation 25.47 10.11 33 472315 897 63015777
Drug dose omission by device 25.29 10.11 3 472345 4798 63011876
Complication of device removal 25.23 10.11 4 472344 5138 63011536
Schizophrenia 25.17 10.11 143 472205 9809 63006865
Ventricular extrasystoles 25.03 10.11 30 472318 11657 63005017
Second primary malignancy 24.99 10.11 14 472334 7939 63008735
Pneumonia 24.98 10.11 2996 469352 453771 62562903
Thrombotic microangiopathy 24.95 10.11 25 472323 10536 63006138
Fear of injection 24.94 10.11 11 472337 7153 63009521
Transplant rejection 24.92 10.11 26 472322 10754 63005920
COVID-19 pneumonia 24.81 10.11 186 472162 14023 63002651
Akathisia 24.81 10.11 19 472329 9127 63007547
Product adhesion issue 24.73 10.11 3 472345 4716 63011958
Plasma cell myeloma 24.62 10.11 161 472187 35744 62980930
Infusion site discomfort 24.61 10.11 41 472307 1405 63015269
Hypocoagulable state 24.37 10.11 37 472311 1170 63015504
Complication of device insertion 24.23 10.11 13 472335 7551 63009123
Insurance issue 24.20 10.11 100 472248 6021 63010653
Musculoskeletal disorder 24.13 10.11 76 472272 20568 62996106
Renal disorder 24.09 10.11 145 472203 32829 62983845
Lip dry 23.98 10.11 197 472151 15273 63001401
Tardive dyskinesia 23.92 10.11 17 472331 8485 63008189
Skin burning sensation 23.91 10.11 36 472312 12698 63003976
Sputum culture positive 23.86 10.11 51 472297 2116 63014558
Uterine perforation 23.76 10.11 11 472337 6952 63009722
Dyskinesia 23.76 10.11 140 472208 31862 62984812
Gait disturbance 23.70 10.11 1117 471231 182061 62834613
Aphasia 23.64 10.11 146 472202 32854 62983820
Pleural effusion 23.52 10.11 521 471827 92689 62923985
Intermenstrual bleeding 23.44 10.11 15 472333 7911 63008763
Anti-cyclic citrullinated peptide antibody 23.34 10.11 106 472242 6652 63010022
Ear infection 23.34 10.11 407 471941 37806 62978868
Product complaint 23.30 10.11 37 472311 12772 63003902
Device breakage 23.29 10.11 31 472317 11511 63005163
Neutrophil count decreased 23.25 10.11 288 472060 56118 62960556
Infusion site rash 23.20 10.11 48 472300 1946 63014728
Lactic acidosis 23.17 10.11 178 472170 38109 62978565
Body temperature fluctuation 23.14 10.11 52 472296 2233 63014441
Cardiac failure acute 23.12 10.11 22 472326 9501 63007173
Hepatitis cholestatic 23.10 10.11 107 472241 6771 63009903
Blood pH decreased 23.06 10.11 56 472292 2531 63014143
Polyneuropathy 23.05 10.11 46 472302 14543 63002131
Vital capacity decreased 22.99 10.11 44 472304 1684 63014990
Dysphagia 22.97 10.11 493 471855 88092 62928582
Drug ineffective for unapproved indication 22.73 10.11 154 472194 33909 62982765
Drug level increased 22.68 10.11 264 472084 22472 62994202
Pre-existing condition improved 22.52 10.11 17 472331 8227 63008447
Brain death 22.47 10.11 66 472282 3344 63013330
Post transplant lymphoproliferative disorder 22.37 10.11 5 472343 5026 63011648
Analgesic drug level above therapeutic 22.35 10.11 15 472333 168 63016506
Iron deficiency anaemia 22.31 10.11 75 472273 19894 62996780
Mitral valve incompetence 22.29 10.11 73 472275 19521 62997153
Cardiotoxicity 22.29 10.11 18 472330 8420 63008254
Labelled drug-drug interaction medication error 22.26 10.11 41 472307 13358 63003316
Fracture 22.26 10.11 73 472275 19511 62997163
Incorrect dose administered by device 22.22 10.11 3 472345 4345 63012329
Drug eruption 22.12 10.11 124 472224 28570 62988104
Systemic infection 22.03 10.11 4 472344 4656 63012018
Speech disorder 21.81 10.11 195 472153 40434 62976240
Product preparation error 21.78 10.11 9 472339 6083 63010591
Premature delivery 21.68 10.11 134 472214 30147 62986527
Meniscus injury 21.68 10.11 13 472335 7101 63009573
Angina unstable 21.57 10.11 13 472335 7082 63009592
X-ray abnormal 21.49 10.11 118 472230 7992 63008682
Mood swings 21.45 10.11 67 472281 18181 62998493
Hepatic cirrhosis 21.25 10.11 103 472245 24631 62992043
Pneumonia aspiration 21.18 10.11 160 472188 34380 62982294
Flatulence 21.16 10.11 161 472187 34541 62982133
Joint range of motion decreased 21.12 10.11 349 471999 32079 62984595
Pain in jaw 21.12 10.11 214 472134 43282 62973392
Deafness 21.06 10.11 66 472282 17891 62998783
Concomitant disease aggravated 21.04 10.11 22 472326 9090 63007584
Multiple allergies 20.99 10.11 175 472173 13627 63003047
Therapeutic response shortened 20.98 10.11 156 472192 11732 63004942
Neuroleptic malignant syndrome 20.83 10.11 36 472312 12020 63004654
Skin ulcer 20.81 10.11 212 472136 42833 62973841
Acidosis 20.73 10.11 149 472199 11084 63005590
Tricuspid valve incompetence 20.71 10.11 49 472299 14572 63002102
Amenorrhoea 20.65 10.11 26 472322 9888 63006786
Hallucination, auditory 20.64 10.11 40 472308 12784 63003890
Hypothermia 20.55 10.11 172 472176 13409 63003265
Cardiac failure chronic 20.45 10.11 4 472344 4414 63012260
Dysphonia 20.43 10.11 241 472107 47373 62969301
Mental impairment 20.38 10.11 47 472301 14104 63002570
Malaise 20.31 10.11 2748 469600 413206 62603468
Low density lipoprotein increased 20.25 10.11 11 472337 6346 63010328
Blood creatine increased 20.21 10.11 89 472259 5512 63011162
Substance abuse 20.17 10.11 80 472268 4727 63011947
Acute myeloid leukaemia 20.13 10.11 63 472285 17084 62999590
Treatment noncompliance 20.10 10.11 179 472169 37146 62979528
Ductus arteriosus premature closure 20.04 10.11 18 472330 318 63016356
Administration site bruise 20.01 10.11 20 472328 406 63016268
Peripheral venous disease 19.81 10.11 189 472159 15288 63001386
Adjustment disorder with depressed mood 19.80 10.11 137 472211 10067 63006607
Liver transplant 19.79 10.11 49 472299 2242 63014432
Wound infection 19.78 10.11 245 472103 21165 62995509
Hypomagnesaemia 19.63 10.11 129 472219 28608 62988066
Acute respiratory failure 19.63 10.11 163 472185 34322 62982352
Metastases to lymph nodes 19.63 10.11 19 472329 8139 63008535
Multiple-drug resistance 19.54 10.11 7 472341 5163 63011511
Prothrombin time ratio decreased 19.49 10.11 22 472326 516 63016158
Body height decreased 19.40 10.11 28 472320 10050 63006624
Brain stem glioma 19.38 10.11 14 472334 178 63016496
Status epilepticus 19.30 10.11 54 472294 15179 63001495
Disorientation 19.20 10.11 194 472154 39258 62977416
Ventricular fibrillation 19.11 10.11 37 472311 11830 63004844
Macular oedema 19.06 10.11 3 472345 3874 63012800
Dystonia 19.03 10.11 47 472301 13772 63002902
Impaired quality of life 18.88 10.11 47 472301 13736 63002938
Blood immunoglobulin E increased 18.87 10.11 3 472345 3846 63012828
Skin discolouration 18.83 10.11 185 472163 37643 62979031
Reversible airways obstruction 18.74 10.11 42 472306 1800 63014874
Immune reconstitution inflammatory syndrome 18.70 10.11 11 472337 6073 63010601
Cerebral haemorrhage 18.53 10.11 143 472205 30586 62986088
Red cell distribution width increased 18.51 10.11 138 472210 10386 63006288
Skin toxicity 18.48 10.11 6 472342 4708 63011966
Haematuria 18.38 10.11 134 472214 29023 62987651
Ischaemic stroke 18.36 10.11 70 472278 17887 62998787
Pregnancy with contraceptive device 18.36 10.11 6 472342 4688 63011986
Drug tolerance 18.14 10.11 15 472333 6934 63009740
Rheumatoid nodule 18.11 10.11 66 472282 17089 62999585
Pancreatic carcinoma 18.08 10.11 18 472330 7610 63009064
Infusion site urticaria 18.08 10.11 38 472310 1558 63015116
Maternal exposure timing unspecified 18.04 10.11 102 472246 6985 63009689
Coagulation factor X level decreased 18.02 10.11 10 472338 77 63016597
Dysarthria 18.01 10.11 217 472131 42494 62974180
Chronic obstructive pulmonary disease 18.00 10.11 343 472005 62343 62954331
Dislocation of vertebra 17.99 10.11 118 472230 8517 63008157
Hallucination 17.96 10.11 293 472055 54524 62962150
Pharyngeal oedema 17.87 10.11 48 472300 13673 63003001
Hip fracture 17.85 10.11 137 472211 29337 62987337
Blood urine present 17.82 10.11 181 472167 14888 63001786
Transplant dysfunction 17.74 10.11 7 472341 4865 63011809
Dysstasia 17.69 10.11 89 472259 21077 62995597
Cardiomyopathy 17.69 10.11 69 472279 17515 62999159
Abnormal dreams 17.63 10.11 32 472316 10484 63006190
Product residue present 17.60 10.11 4 472344 3975 63012699
Skin lesion 17.58 10.11 145 472203 30576 62986098
Atypical femur fracture 17.55 10.11 9 472339 5363 63011311
Infective pulmonary exacerbation of cystic fibrosis 17.47 10.11 24 472324 8793 63007881
Large intestine polyp 17.40 10.11 21 472327 8136 63008538
Pharyngeal paraesthesia 17.39 10.11 43 472305 1966 63014708
Renal failure neonatal 17.32 10.11 13 472335 176 63016498
Oral discomfort 17.29 10.11 26 472322 9175 63007499
Haemophagocytic lymphohistiocytosis 17.23 10.11 33 472315 10594 63006080
Endophthalmitis 17.16 10.11 3 472345 3589 63013085
Cryopyrin associated periodic syndrome 17.10 10.11 17 472331 343 63016331
Aplasia pure red cell 17.09 10.11 6 472342 4481 63012193
Caesarean section 17.02 10.11 67 472281 16965 62999709
Tinnitus 17.00 10.11 176 472172 35452 62981222
Invasive ductal breast carcinoma 16.98 10.11 16 472332 6942 63009732
Uterine cancer 16.91 10.11 7 472341 4726 63011948
Galactorrhoea 16.81 10.11 5 472343 4150 63012524
Hemivertebra 16.79 10.11 11 472337 118 63016556
Rheumatoid lung 16.76 10.11 4 472344 3844 63012830
Coagulation factor VII level decreased 16.73 10.11 10 472338 90 63016584
Post procedural pulmonary embolism 16.70 10.11 15 472333 265 63016409
Inappropriate antidiuretic hormone secretion 16.64 10.11 59 472289 15403 63001271
Ankylosing spondylitis 16.57 10.11 33 472315 10441 63006233
Unintended pregnancy 16.55 10.11 13 472335 6166 63010508
Vertigo 16.49 10.11 330 472018 59557 62957117
Diplopia 16.47 10.11 106 472242 23622 62993052
Embedded device 16.45 10.11 3 472345 3480 63013194
Joint stiffness 16.43 10.11 216 472132 41653 62975021
Torsade de pointes 16.43 10.11 48 472300 13303 63003371
Arrhythmia 16.38 10.11 193 472155 37947 62978727
Head injury 16.28 10.11 128 472220 27268 62989406
Blood bilirubin increased 16.15 10.11 376 471972 36764 62979910
Multiple organ dysfunction syndrome 16.15 10.11 311 472037 56441 62960233
Dermatitis 16.14 10.11 68 472280 16890 62999784
Foot operation 16.09 10.11 18 472330 7213 63009461
Aspartate aminotransferase 16.06 10.11 18 472330 419 63016255
Post cholecystectomy syndrome 15.99 10.11 18 472330 421 63016253
Asthenia 15.89 10.11 2559 469789 381045 62635629
Drug level below therapeutic 15.83 10.11 75 472273 4791 63011883
Pericardial effusion 15.81 10.11 145 472203 29913 62986761
Chest pain 15.81 10.11 1387 470961 214572 62802102
Bacterial test 15.75 10.11 30 472318 1144 63015530
Accidental death 15.75 10.11 41 472307 1935 63014739
Oral pruritus 15.73 10.11 45 472303 2246 63014428
Sleep disorder 15.72 10.11 750 471598 80816 62935858
Hypoacusis 15.71 10.11 110 472238 24041 62992633
Somnambulism 15.70 10.11 11 472337 5532 63011142
Tooth extraction 15.68 10.11 33 472315 10231 63006443
Delusion 15.68 10.11 42 472306 11975 63004699
Vaginal flatulence 15.63 10.11 57 472291 3236 63013438
Autoimmune disorder 15.63 10.11 196 472152 16981 62999693
Haemoglobin decreased 15.62 10.11 904 471444 144581 62872093
Respiratory symptom 15.55 10.11 3 472345 3344 63013330
SARS-CoV-2 test positive 15.54 10.11 108 472240 7948 63008726
Colorectal cancer 15.46 10.11 4 472344 3641 63013033
Blood loss anaemia 15.44 10.11 27 472321 8974 63007700
Movement disorder 15.43 10.11 96 472252 21565 62995109
Device leakage 15.43 10.11 18 472330 7078 63009596
Osmolar gap 15.36 10.11 10 472338 106 63016568
Product physical issue 15.32 10.11 9 472339 4971 63011703
Gastrointestinal pain 15.30 10.11 31 472317 9745 63006929
Abdominal pain lower 15.25 10.11 120 472228 25558 62991116
Dysphoria 15.24 10.11 9 472339 4957 63011717
Prescribed overdose 15.24 10.11 347 472001 33806 62982868
Device deployment issue 15.24 10.11 5 472343 3897 63012777
Device related thrombosis 15.23 10.11 38 472310 1747 63014927
Hip arthroplasty 15.15 10.11 463 471885 47183 62969491
Eye haemorrhage 15.02 10.11 25 472323 8471 63008203
Haemoglobin urine present 14.91 10.11 24 472324 799 63015875
Respiratory tract congestion 14.89 10.11 75 472273 17757 62998917
Granulocyte count increased 14.88 10.11 25 472323 863 63015811
Clostridium test positive 14.85 10.11 55 472293 3146 63013528
Therapy change 14.82 10.11 14 472334 6067 63010607
Ketoacidosis 14.81 10.11 7 472341 4371 63012303
Dyslipidaemia 14.77 10.11 20 472328 7373 63009301
Mood altered 14.73 10.11 58 472290 14685 63001989
Allergy to chemicals 14.73 10.11 53 472295 2989 63013685
Potentiating drug interaction 14.68 10.11 7 472341 4349 63012325
Anticholinergic syndrome 14.66 10.11 45 472303 2337 63014337
Lung neoplasm malignant 14.52 10.11 86 472262 19547 62997127
Oral pain 14.50 10.11 138 472210 28256 62988418
Device failure 14.46 10.11 14 472334 5997 63010677
Tendonitis 14.46 10.11 86 472262 19529 62997145
Febrile bone marrow aplasia 14.45 10.11 20 472328 7305 63009369
Cellulitis 14.45 10.11 482 471866 81476 62935198
Gastritis 14.43 10.11 193 472155 37110 62979564
Lupus vulgaris 14.43 10.11 85 472263 5909 63010765
Generalised tonic-clonic seizure 14.40 10.11 142 472206 28874 62987800
Prothrombin time prolonged 14.40 10.11 121 472227 9443 63007231
Thyroid neoplasm 14.27 10.11 6 472342 4013 63012661
Emotional distress 14.25 10.11 164 472184 32385 62984289
Blood creatinine decreased 14.24 10.11 80 472268 5465 63011209
Eye pruritus 14.22 10.11 81 472267 18590 62998084
Bundle branch block left 14.20 10.11 19 472329 7040 63009634
Congestive cardiomyopathy 14.19 10.11 15 472333 6167 63010507
Coagulation factor decreased 14.18 10.11 9 472339 91 63016583
COVID-19 immunisation 14.17 10.11 37 472311 1750 63014924
Lymphadenopathy 14.15 10.11 201 472147 38257 62978417
Aspartate aminotransferase increased 14.14 10.11 814 471534 89463 62927211
Aspergillus infection 14.14 10.11 24 472324 8069 63008605
Metastases to central nervous system 14.11 10.11 50 472298 13055 63003619
Patent ductus arteriosus 14.07 10.11 7 472341 4243 63012431
Cytopenia 14.06 10.11 42 472306 11559 63005115
Band neutrophil count increased 14.05 10.11 16 472332 379 63016295
Congestive hepatopathy 14.03 10.11 51 472297 2891 63013783
Musculoskeletal stiffness 14.01 10.11 1574 470774 183044 62833630
Ventricular tachycardia 14.00 10.11 89 472259 19890 62996784
Abortion induced 13.97 10.11 35 472313 10207 63006467
Epstein-Barr virus infection 13.95 10.11 24 472324 8026 63008648
Inflammation 13.90 10.11 747 471601 81526 62935148
Blood triglycerides increased 13.88 10.11 47 472301 12441 63004233
Aggression 13.87 10.11 110 472238 23388 62993286
Polycystic ovaries 13.86 10.11 8 472340 4463 63012211
Cells in urine 13.73 10.11 12 472336 204 63016470
Supraventricular tachycardia 13.72 10.11 57 472291 14214 63002460
Pelvic pain 13.63 10.11 53 472295 13466 63003208
Tumour marker increased 13.60 10.11 10 472338 4905 63011769
Sensory disturbance 13.53 10.11 54 472294 13618 63003056
Gastrointestinal toxicity 13.48 10.11 23 472325 7718 63008956
Eosinophil percentage increased 13.45 10.11 26 472322 1003 63015671
White coat hypertension 13.44 10.11 21 472327 681 63015993
Cardiovascular disorder 13.44 10.11 44 472304 11768 63004906
Administration site erythema 13.44 10.11 22 472326 743 63015931
Abnormal loss of weight 13.30 10.11 14 472334 5768 63010906
Neoplasm malignant 13.25 10.11 150 472198 29711 62986963
Mean cell haemoglobin concentration increased 13.25 10.11 18 472330 513 63016161
Intestinal haemorrhage 13.25 10.11 6 472342 3841 63012833
Ductus arteriosus stenosis foetal 13.24 10.11 11 472337 174 63016500
Aortic valve incompetence 13.22 10.11 15 472333 5973 63010701
Myelocyte count increased 13.19 10.11 15 472333 355 63016319
Vein collapse 13.18 10.11 26 472322 1018 63015656
Smear cervix abnormal 13.16 10.11 50 472298 2896 63013778
Skin infection 13.15 10.11 170 472178 14832 63001842
Injection site haematoma 13.13 10.11 19 472329 6813 63009861
Renal papillary necrosis 13.04 10.11 13 472335 263 63016411
Toxicologic test abnormal 13.03 10.11 21 472327 700 63015974
Lupus-like syndrome 12.96 10.11 64 472284 15231 63001443
Enthesopathy 12.90 10.11 28 472320 8586 63008088
Colon gangrene 12.89 10.11 4 472344 4 63016670
Drug tolerance decreased 12.88 10.11 192 472156 17281 62999393
Administration site pruritus 12.86 10.11 14 472334 315 63016359
Personality change 12.82 10.11 20 472328 6953 63009721
Sleep disorder due to a general medical condition 12.79 10.11 47 472301 12141 63004533
Focal dyscognitive seizures 12.79 10.11 3 472345 2918 63013756
Mania 12.78 10.11 48 472300 12319 63004355
Gout 12.76 10.11 53 472295 13218 63003456
Pain 12.76 10.11 5887 466461 734741 62281933
Suspected COVID-19 12.72 10.11 45 472303 2517 63014157
Small for dates baby 12.69 10.11 6 472342 3745 63012929
Stress fracture 12.68 10.11 25 472323 7938 63008736
Vitamin K deficiency 12.66 10.11 16 472332 424 63016250
Osteomyelitis 12.64 10.11 128 472220 25892 62990782
Muscle disorder 12.64 10.11 11 472337 4958 63011716
Haemolysis 12.62 10.11 90 472258 6678 63009996
Glutathione decreased 12.61 10.11 6 472342 32 63016642
Lymphoproliferative disorder 12.61 10.11 4 472344 3186 63013488
Diffuse large B-cell lymphoma 12.58 10.11 19 472329 6693 63009981
Hysterectomy 12.54 10.11 33 472315 9466 63007208
Nail bed inflammation 12.48 10.11 15 472333 377 63016297
Ventricular arrhythmia 12.45 10.11 59 472289 3769 63012905
Fixed eruption 12.36 10.11 27 472321 1137 63015537
Snoring 12.36 10.11 8 472340 4194 63012480
Visual impairment 12.34 10.11 508 471840 83938 62932736
Inhibitory drug interaction 12.33 10.11 3 472345 2846 63013828
Abnormal behaviour 12.32 10.11 101 472247 21325 62995349
Band neutrophil percentage increased 12.31 10.11 12 472336 236 63016438
Skin cancer 12.28 10.11 44 472304 11451 63005223
Ankle fracture 12.27 10.11 80 472268 17775 62998899
Coronary arterial stent insertion 12.20 10.11 3 472345 2826 63013848
Intervertebral disc protrusion 12.20 10.11 115 472233 23594 62993080
Injury associated with device 12.19 10.11 6 472342 3660 63013014
Bronchopulmonary aspergillosis 12.18 10.11 29 472319 8606 63008068
Eating disorder 12.18 10.11 87 472261 18929 62997745
Limb discomfort 12.14 10.11 152 472196 29564 62987110
Intervertebral disc degeneration 12.12 10.11 68 472280 15664 63001010
Nerve injury 12.06 10.11 36 472312 9910 63006764
Balance disorder 12.05 10.11 755 471593 83667 62933007
Bone disorder 12.05 10.11 101 472247 21225 62995449
Lung infiltration 11.98 10.11 61 472287 14402 63002272
Cystitis 11.98 10.11 512 471836 54479 62962195
Glucose tolerance impaired 11.96 10.11 19 472329 6558 63010116
Abdominal pain upper 11.94 10.11 1731 470617 204713 62811961
Emotional disorder 11.91 10.11 55 472293 13324 63003350
Fungal rhinitis 11.91 10.11 6 472342 37 63016637
Alpha 1 microglobulin increased 11.90 10.11 7 472341 61 63016613
Thoracic vertebral fracture 11.88 10.11 10 472338 4582 63012092
Hypersensitivity vasculitis 11.86 10.11 8 472340 4104 63012570
Pancreatitis 11.86 10.11 276 472072 48779 62967895
Drug screen positive 11.86 10.11 56 472292 3573 63013101
Blood immunoglobulin A increased 11.85 10.11 21 472327 757 63015917
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.82 10.11 38 472310 2023 63014651
Device related infection 11.81 10.11 114 472234 23278 62993396
Arteriosclerosis 11.80 10.11 37 472311 10029 63006645
Papule 11.78 10.11 15 472333 5676 63010998
Bone lesion 11.66 10.11 16 472332 5865 63010809
Tongue disorder 11.64 10.11 40 472308 10540 63006134
Gastroenteritis 11.63 10.11 134 472214 26456 62990218
Infusion site discolouration 11.62 10.11 22 472326 835 63015839
Intraocular pressure increased 11.59 10.11 17 472331 6061 63010613
Subdural haematoma 11.55 10.11 61 472287 14267 63002407
Anxiety disorder 11.52 10.11 8 472340 4042 63012632
Gingival disorder 11.47 10.11 6 472342 3536 63013138
Eczema 11.45 10.11 170 472178 32121 62984553
Left ventricular dysfunction 11.45 10.11 48 472300 11940 63004734
Necrotic lymphadenopathy 11.44 10.11 7 472341 66 63016608
Spinal compression fracture 11.41 10.11 61 472287 14222 63002452
Total lung capacity decreased 11.41 10.11 39 472309 2144 63014530
Thyroid cancer 11.39 10.11 15 472333 5596 63011078
Urine analysis abnormal 11.35 10.11 70 472278 4946 63011728
Cardiac arrest 11.32 10.11 817 471531 91728 62924946
Vasoplegia syndrome 11.31 10.11 33 472315 1666 63015008
Catheter site bruise 11.29 10.11 16 472332 475 63016199
Shoulder arthroplasty 11.26 10.11 8 472340 3994 63012680
Diffuse axonal injury 11.26 10.11 8 472340 99 63016575
Osteoarthritis 11.23 10.11 587 471761 94756 62921918
Blood immunoglobulin A decreased 11.20 10.11 28 472320 1289 63015385
Human herpesvirus 6 infection 11.18 10.11 4 472344 2953 63013721
Renal cancer 11.16 10.11 15 472333 5547 63011127
Staphylococcal infection 11.16 10.11 228 472120 41028 62975646
Haematochezia 11.13 10.11 308 472040 53236 62963438
Cough 11.13 10.11 1962 470386 290781 62725893
Spinal pain 11.12 10.11 55 472293 13084 63003590
Transfusion-related acute lung injury 11.12 10.11 9 472339 137 63016537
Granuloma 11.10 10.11 16 472332 5745 63010929
Bradypnoea 11.03 10.11 54 472294 3496 63013178
Intentional self-injury 11.02 10.11 130 472218 25557 62991117
Acute graft versus host disease 11.02 10.11 10 472338 4418 63012256
Bipolar disorder 11.02 10.11 27 472321 7933 63008741
Orbital compartment syndrome 11.01 10.11 7 472341 71 63016603
C-reactive protein 10.97 10.11 68 472280 4814 63011860
Femoral neck fracture 10.96 10.11 30 472318 8493 63008181
Dissociation 10.95 10.11 4 472344 2915 63013759
Leukoencephalopathy 10.94 10.11 10 472338 4403 63012271
Autonomic dysreflexia 10.93 10.11 13 472335 323 63016351
Cachexia 10.93 10.11 16 472332 5710 63010964
Haemorrhage intracranial 10.89 10.11 57 472291 13362 63003312
Epilepsy with myoclonic-atonic seizures 10.86 10.11 8 472340 105 63016569
Restless legs syndrome 10.82 10.11 87 472261 18444 62998230
Pneumonia viral 10.77 10.11 98 472250 7824 63008850
Left ventricular failure 10.75 10.11 16 472332 5671 63011003
Rheumatoid factor 10.75 10.11 13 472335 329 63016345
Blood glucose abnormal 10.74 10.11 27 472321 7865 63008809
Hyperhidrosis 10.70 10.11 675 471673 107161 62909513
Base excess 10.69 10.11 7 472341 75 63016599
Hypoaesthesia 10.68 10.11 1093 471255 167300 62849374
Osteolysis 10.68 10.11 4 472344 2870 63013804
Mixed liver injury 10.67 10.11 66 472282 4669 63012005
Pelvic fracture 10.66 10.11 57 472291 13291 63003383
Uterine leiomyoma 10.65 10.11 34 472314 9164 63007510
Hypervolaemia 10.63 10.11 148 472200 28265 62988409
Bronchospasm 10.61 10.11 80 472268 17200 62999474
Temperature regulation disorder 10.56 10.11 80 472268 6052 63010622
Taste disorder 10.55 10.11 59 472289 13603 63003071
Central nervous system lesion 10.52 10.11 42 472306 10593 63006081
Nephrogenic systemic fibrosis 10.52 10.11 11 472337 4545 63012129
Small fibre neuropathy 10.51 10.11 15 472333 448 63016226
Dysuria 10.50 10.11 182 472166 33556 62983118
Neonatal respiratory acidosis 10.50 10.11 10 472338 191 63016483
Agranulocytosis 10.48 10.11 128 472220 25006 62991668
Pallor 10.47 10.11 162 472186 30406 62986268
Restlessness 10.47 10.11 155 472193 29298 62987376
Cyanosis neonatal 10.41 10.11 14 472334 395 63016279
Pre-eclampsia 10.41 10.11 34 472314 9099 63007575
Allergy test negative 10.37 10.11 10 472338 194 63016480
Monocyte count increased 10.34 10.11 93 472255 7400 63009274
Blood lactic acid increased 10.33 10.11 89 472259 6997 63009677
Unresponsive to stimuli 10.32 10.11 327 472021 33489 62983185
Product monitoring error 10.32 10.11 11 472337 4505 63012169
Blood pressure systolic decreased 10.31 10.11 92 472256 7305 63009369
Paraesthesia ear 10.30 10.11 11 472337 242 63016432
Transaminases increased 10.29 10.11 306 472042 31061 62985613
Pollakiuria 10.28 10.11 146 472202 27791 62988883
Blood uric acid decreased 10.18 10.11 20 472328 781 63015893
Jaw disorder 10.16 10.11 15 472333 5334 63011340
Total lung capacity increased 10.15 10.11 39 472309 2271 63014403
Application site rash 10.11 10.11 3 472345 2495 63014179

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1296.98 10.24 3006 172942 197356 34583627
Completed suicide 1227.19 10.24 1950 173998 96218 34684765
Exposure to toxic agent 560.15 10.24 302 175646 3373 34777610
Infusion related reaction 518.87 10.24 946 175002 52111 34728872
Blood pressure fluctuation 473.03 10.24 609 175339 24640 34756343
Overdose 365.77 10.24 1148 174800 89911 34691072
Acute hepatic failure 306.14 10.24 366 175582 13708 34767275
Intentional product misuse 294.00 10.24 685 175263 44926 34736057
Intentional overdose 277.22 10.24 652 175296 43022 34737961
Drug ineffective 249.90 10.24 1319 174629 455432 34325551
Heart rate decreased 240.88 10.24 509 175439 31236 34749747
Hepatic cytolysis 190.23 10.24 295 175653 14201 34766782
Blood pressure increased 185.36 10.24 906 175042 87196 34693787
Cytokine release syndrome 154.41 10.24 350 175598 22527 34758456
Metabolic acidosis 133.38 10.24 503 175445 43177 34737806
Intentional product use issue 123.49 10.24 612 175336 59204 34721779
Oxygen saturation decreased 122.22 10.24 566 175382 53252 34727731
Blood pressure systolic increased 117.62 10.24 316 175632 22636 34758347
Myocardial infarction 115.93 10.24 275 175673 120810 34660173
COVID-19 112.08 10.24 721 175227 76829 34704154
Blood pressure diastolic abnormal 110.89 10.24 129 175819 4689 34776294
Analgesic drug level increased 107.64 10.24 62 175886 794 34780189
Hepatotoxicity 104.31 10.24 290 175658 21195 34759788
Coagulopathy 103.97 10.24 275 175673 19514 34761469
Anion gap 99.02 10.24 59 175889 808 34780175
Cardiac failure congestive 98.63 10.24 167 175781 83103 34697880
Drug resistance 87.55 10.24 13 175935 25914 34755069
Product dose omission issue 87.43 10.24 309 175639 119402 34661581
Suicide attempt 82.69 10.24 403 175545 38713 34742270
Body temperature decreased 80.91 10.24 193 175755 12841 34768142
Sinusitis 80.09 10.24 416 175532 40986 34739997
Poisoning 78.02 10.24 183 175765 12043 34768940
Blood pressure diastolic increased 77.01 10.24 110 175838 4915 34776068
Medication error 76.86 10.24 293 175655 25272 34755711
Blood pressure systolic abnormal 76.68 10.24 97 175851 3851 34777132
Pyroglutamic acidosis 76.28 10.24 39 175909 387 34780596
Treatment failure 75.59 10.24 74 175874 46623 34734360
Accidental overdose 74.41 10.24 247 175701 19893 34761090
Febrile neutropenia 73.97 10.24 1031 174917 135818 34645165
Infusion site extravasation 72.40 10.24 99 175849 4245 34776738
Heart rate irregular 71.50 10.24 208 175740 15599 34765384
Diarrhoea 71.39 10.24 1460 174488 388452 34392531
Suspected suicide 67.05 10.24 100 175848 4648 34776335
Respiratory depression 63.41 10.24 203 175745 16042 34764941
Poisoning deliberate 62.06 10.24 128 175820 7716 34773267
Cardio-respiratory arrest 61.78 10.24 483 175465 54790 34726193
Hypotension 60.42 10.24 1501 174447 220148 34560835
Blood pressure diastolic decreased 60.09 10.24 138 175810 8956 34772027
Alanine aminotransferase increased 58.82 10.24 644 175304 80171 34700812
Respiratory arrest 57.18 10.24 286 175662 27757 34753226
Substance abuse 56.17 10.24 121 175827 7520 34773463
Coronary artery disease 56.15 10.24 98 175850 48207 34732776
Infusion site pain 55.66 10.24 82 175866 3769 34777214
Cardiac failure 55.54 10.24 253 175695 90995 34689988
Hepatic necrosis 55.15 10.24 81 175867 3713 34777270
Chills 54.54 10.24 636 175312 80407 34700576
Drug abuse 54.48 10.24 749 175199 98347 34682636
Appendicolith 54.07 10.24 128 175820 8473 34772510
Inappropriate schedule of product administration 52.73 10.24 512 175436 61784 34719199
Infusion site swelling 50.59 10.24 63 175885 2461 34778522
Toxic epidermal necrolysis 50.10 10.24 229 175719 21417 34759566
Dizziness 48.72 10.24 790 175158 217731 34563252
Wrong technique in product usage process 48.54 10.24 66 175882 35920 34745063
Liver injury 48.46 10.24 175 175773 14703 34766280
Abdominal pain 48.16 10.24 1120 174828 162498 34618485
Body temperature increased 48.10 10.24 194 175754 17174 34763809
Renal cortical necrosis 47.10 10.24 23 175925 205 34780778
Therapeutic product effect incomplete 44.28 10.24 120 175828 50421 34730562
Poor venous access 43.89 10.24 87 175861 5096 34775887
Heart rate increased 41.25 10.24 385 175563 45958 34735025
Depressed level of consciousness 41.24 10.24 362 175586 42479 34738504
Therapeutic response shortened 41.05 10.24 105 175843 7299 34773684
Aspartate aminotransferase increased 39.99 10.24 519 175429 67264 34713719
Renal impairment 39.37 10.24 296 175652 94217 34686766
Coma 38.43 10.24 375 175573 45303 34735680
Anaemia 38.41 10.24 888 175060 232447 34548536
Methaemoglobinaemia 37.70 10.24 66 175882 3515 34777468
Appendicitis 37.56 10.24 161 175787 14646 34766337
Ear infection 37.36 10.24 125 175823 10106 34770877
Body temperature fluctuation 37.31 10.24 44 175904 1623 34779360
Depression 37.24 10.24 311 175637 96787 34684196
Asthenia 36.91 10.24 946 175002 244305 34536678
Memory impairment 34.90 10.24 107 175841 43211 34737772
Injection site pain 34.62 10.24 92 175856 38913 34742070
Disease progression 34.24 10.24 363 175585 107714 34673269
Myelosuppression 34.20 10.24 28 175920 19237 34761746
Pharyngeal paraesthesia 34.10 10.24 28 175920 657 34780326
Exposure via ingestion 33.80 10.24 48 175900 2133 34778850
Pyrexia 33.80 10.24 2022 173926 330991 34449992
Dyspnoea 33.71 10.24 1552 174396 375230 34405753
Neuropathy peripheral 33.62 10.24 263 175685 83000 34697983
Product prescribing error 33.03 10.24 40 175908 22887 34758096
Infusion site erythema 32.28 10.24 48 175900 2225 34778758
Tachycardia 31.65 10.24 601 175347 84171 34696812
Infusion site pruritus 31.58 10.24 29 175919 794 34780189
Cerebrovascular accident 31.46 10.24 274 175674 84537 34696446
Stevens-Johnson syndrome 31.13 10.24 180 175768 18459 34762524
Full blood count abnormal 30.88 10.24 29 175919 18639 34762344
Hepatic failure 30.79 10.24 287 175661 34244 34746739
Drug interaction 30.74 10.24 884 175064 225062 34555921
Prostate cancer 30.50 10.24 100 175848 39549 34741434
Infusion site bruising 29.96 10.24 27 175921 721 34780262
Bone marrow failure 29.94 10.24 64 175884 29189 34751794
Malignant neoplasm progression 29.83 10.24 291 175657 87755 34693228
Nasopharyngitis 29.62 10.24 506 175442 69462 34711521
Myocardial fibrosis 29.15 10.24 33 175915 1164 34779819
Asthma 28.56 10.24 114 175834 42542 34738441
Bladder cancer 28.47 10.24 24 175924 16254 34764729
Hepatitis fulminant 28.14 10.24 64 175884 4126 34776857
Neutrophil percentage increased 27.90 10.24 40 175908 1793 34779190
Blood phosphorus increased 27.90 10.24 94 175854 7627 34773356
Ductus arteriosus premature closure 27.84 10.24 17 175931 244 34780739
Head discomfort 27.79 10.24 63 175885 4053 34776930
Respiratory rate increased 27.78 10.24 111 175837 9783 34771200
Therapeutic response decreased 27.67 10.24 67 175881 29246 34751737
Fatigue 27.52 10.24 1556 174392 369097 34411886
Feeling abnormal 27.30 10.24 196 175752 63039 34717944
Hospitalisation 27.25 10.24 171 175777 56731 34724252
Cerebral haemorrhage 26.95 10.24 88 175860 34849 34746134
Decreased appetite 26.85 10.24 635 175313 165757 34615226
Anion gap abnormal 26.81 10.24 15 175933 181 34780802
Acute myocardial infarction 25.95 10.24 161 175787 53558 34727425
Generalised bullous fixed drug eruption 24.66 10.24 11 175937 78 34780905
Balance disorder 24.55 10.24 113 175835 40541 34740442
Visual acuity reduced 24.53 10.24 27 175921 16122 34764861
Vomiting 24.40 10.24 1500 174448 246121 34534862
Mydriasis 24.31 10.24 86 175862 7151 34773832
Fixed eruption 24.28 10.24 36 175912 1664 34779319
Pemphigus 23.96 10.24 35 175913 1596 34779387
Osteonecrosis of jaw 23.93 10.24 33 175915 17856 34763127
Vital functions abnormal 23.77 10.24 16 175932 274 34780709
Psoriasis 23.37 10.24 108 175840 38704 34742279
Acidosis 23.28 10.24 113 175835 10832 34770151
Blood pH decreased 23.26 10.24 42 175906 2292 34778691
Progressive multifocal leukoencephalopathy 23.23 10.24 10 175938 9754 34771229
Throat irritation 23.03 10.24 110 175838 10475 34770508
Oesophageal carcinoma 22.99 10.24 9 175939 9295 34771688
Interstitial lung disease 22.85 10.24 214 175734 65068 34715915
Infusion site rash 22.80 10.24 20 175928 515 34780468
Cerebral infarction 22.70 10.24 67 175881 27388 34753595
Labelled drug-drug interaction medication error 22.67 10.24 25 175923 14914 34766069
Sopor 22.35 10.24 17 175931 12119 34768864
Urine sodium decreased 22.20 10.24 13 175935 172 34780811
SARS-CoV-2 test positive 22.12 10.24 73 175875 5860 34775123
Glycosylated haemoglobin increased 22.11 10.24 15 175933 11345 34769638
Visual impairment 21.92 10.24 99 175849 35703 34745280
Syncope 21.89 10.24 326 175622 91125 34689858
Chronic gastrointestinal bleeding 21.73 10.24 16 175932 318 34780665
Infusion site haemorrhage 21.64 10.24 26 175922 978 34780005
Acute lung injury 21.60 10.24 32 175916 1478 34779505
Enterocolitis infectious 21.54 10.24 34 175914 1661 34779322
Insomnia 21.36 10.24 381 175567 103526 34677457
Product quality issue 21.24 10.24 33 175915 17002 34763981
International normalised ratio increased 21.03 10.24 345 175603 46982 34734001
Lymphocyte count abnormal 21.03 10.24 28 175920 1170 34779813
Rheumatoid arthritis 20.98 10.24 289 175659 37949 34743034
Immune reconstitution inflammatory syndrome 20.79 10.24 9 175939 8750 34772233
Lymphocyte percentage decreased 20.78 10.24 38 175910 2094 34778889
Dyspnoea exertional 20.75 10.24 130 175818 43149 34737834
Therapeutic product effect decreased 20.72 10.24 97 175851 34646 34746337
Dehydration 20.13 10.24 499 175449 129470 34651513
Haematotoxicity 20.13 10.24 8 175940 8186 34772797
Hyperaesthesia 20.05 10.24 60 175888 4570 34776413
Oedema peripheral 19.94 10.24 455 175493 119357 34661626
Cardiogenic shock 19.75 10.24 213 175735 26405 34754578
Aplastic anaemia 19.73 10.24 99 175849 9617 34771366
Consciousness fluctuating 19.70 10.24 27 175921 1160 34779823
Therapy non-responder 19.60 10.24 116 175832 39030 34741953
Lung neoplasm malignant 19.57 10.24 36 175912 17359 34763624
Granulomatosis with polyangiitis 19.39 10.24 27 175921 1178 34779805
Graft versus host disease 19.21 10.24 15 175933 10554 34770429
Aminoaciduria 19.11 10.24 14 175934 276 34780707
Flushing 19.01 10.24 248 175700 32172 34748811
Immune effector cell-associated neurotoxicity syndrome 18.89 10.24 51 175897 3662 34777321
Dry skin 18.87 10.24 87 175861 31200 34749783
Erectile dysfunction 18.83 10.24 48 175900 20589 34760394
Incorrect drug administration rate 18.70 10.24 32 175916 1673 34779310
Oxygen saturation abnormal 18.50 10.24 30 175918 1500 34779483
Post transplant lymphoproliferative disorder 18.45 10.24 5 175943 6523 34774460
Inadequate analgesia 18.40 10.24 44 175904 2931 34778052
Mixed liver injury 18.32 10.24 43 175905 2830 34778153
Insurance issue 18.20 10.24 35 175913 2004 34778979
Cerebral artery thrombosis 18.14 10.24 21 175927 759 34780224
Diabetes mellitus 18.01 10.24 150 175798 46723 34734260
Hypoxia 18.01 10.24 383 175565 54712 34726271
Cardiac disorder 17.97 10.24 135 175813 42991 34737992
Myopathy 17.90 10.24 19 175929 11535 34769448
Accident 17.84 10.24 61 175887 4986 34775997
Pathogen resistance 17.82 10.24 13 175935 9469 34771514
Prostatic specific antigen increased 17.77 10.24 29 175919 14651 34766332
Brain scan abnormal 17.69 10.24 22 175926 858 34780125
Gait inability 17.64 10.24 50 175898 20708 34760275
C-reactive protein abnormal 17.63 10.24 11 175937 8699 34772284
Throat tightness 17.57 10.24 86 175862 8272 34772711
No adverse event 17.51 10.24 58 175890 22869 34758114
Cytopenia 17.49 10.24 23 175925 12700 34768283
Injection site reaction 17.47 10.24 24 175924 13009 34767974
Transaminases increased 17.36 10.24 209 175739 26614 34754369
Cardiac failure chronic 17.31 10.24 9 175939 7870 34773113
Delusion of grandeur 17.20 10.24 25 175923 1135 34779848
COVID-19 pneumonia 17.17 10.24 145 175803 16822 34764161
Atrial fibrillation 17.08 10.24 477 175471 121916 34659067
Therapy partial responder 17.04 10.24 14 175934 9602 34771381
Akathisia 16.75 10.24 10 175938 8099 34772884
Somnolence 16.66 10.24 701 175247 110415 34670568
Gynaecomastia 16.62 10.24 16 175932 10164 34770819
Osteonecrosis 16.59 10.24 31 175917 14859 34766124
Cholestasis 16.58 10.24 208 175740 26740 34754243
Deep vein thrombosis 16.52 10.24 230 175718 65018 34715965
Prothrombin time prolonged 16.47 10.24 92 175856 9314 34771669
Ductus arteriosus stenosis foetal 16.41 10.24 11 175937 187 34780796
Diabetic ketoacidosis 16.40 10.24 42 175906 17990 34762993
Hyperlipidaemia 16.40 10.24 30 175918 14499 34766484
Sulphaemoglobinaemia 16.25 10.24 6 175942 24 34780959
Anal fissure 16.19 10.24 53 175895 4237 34776746
Drug ineffective for unapproved indication 16.11 10.24 63 175885 23652 34757331
Clostridium test positive 16.10 10.24 45 175903 3297 34777686
Rhinalgia 16.06 10.24 23 175925 1030 34779953
Failure to suspend medication 15.97 10.24 15 175933 423 34780560
Bilirubin urine present 15.83 10.24 10 175938 153 34780830
Bezoar 15.81 10.24 24 175924 1133 34779850
Injection site swelling 15.68 10.24 21 175927 11506 34769477
Blood glucose increased 15.56 10.24 239 175709 66479 34714504
Infusion site nodule 15.44 10.24 9 175939 118 34780865
Drug-induced liver injury 15.44 10.24 217 175731 28615 34752368
Rhinitis 15.37 10.24 68 175880 6270 34774713
Hypertriglyceridaemia 15.34 10.24 12 175936 8436 34772547
Renal papillary necrosis 15.33 10.24 10 175938 162 34780821
Product substitution issue 15.20 10.24 17 175931 10078 34770905
Tooth infection 15.20 10.24 71 175877 6700 34774283
Vanishing bile duct syndrome 15.18 10.24 22 175926 996 34779987
Encephalopathy 15.15 10.24 256 175692 35063 34745920
Victim of chemical submission 15.09 10.24 7 175941 55 34780928
Urethral valves 14.89 10.24 12 175936 274 34780709
Electrocardiogram QT prolonged 14.87 10.24 133 175815 40819 34740164
Dependent personality disorder 14.86 10.24 8 175940 89 34780894
Haemolysis 14.73 10.24 80 175868 8014 34772969
Multiple organ dysfunction syndrome 14.58 10.24 496 175452 76070 34704913
Psoriatic arthropathy 14.49 10.24 51 175897 19747 34761236
Agitation 14.48 10.24 385 175563 57014 34723969
Therapy cessation 14.34 10.24 41 175907 16932 34764051
Urticaria 14.23 10.24 413 175535 61964 34719019
Drug level below therapeutic 14.20 10.24 61 175887 5554 34775429
Sudden infant death syndrome 14.19 10.24 11 175937 237 34780746
Obstructive airways disorder 14.16 10.24 36 175912 15458 34765525
Sexual dysfunction 14.15 10.24 7 175941 6296 34774687
Immunoglobulin G4 related disease 14.12 10.24 9 175939 140 34780843
Fall 14.05 10.24 857 175091 202028 34578955
Pancytopenia 14.01 10.24 368 175580 94789 34686194
Contraindicated product administered 14.01 10.24 58 175890 21423 34759560
Severe invasive streptococcal infection 13.89 10.24 6 175942 39 34780944
Unresponsive to stimuli 13.78 10.24 205 175743 27364 34753619
COVID-19 immunisation 13.76 10.24 11 175937 248 34780735
Tooth injury 13.72 10.24 23 175925 1182 34779801
Off label use 13.69 10.24 2355 173593 417169 34363814
Blood triglycerides increased 13.65 10.24 32 175916 14127 34766856
Hypotensive crisis 13.64 10.24 7 175941 70 34780913
Angina pectoris 13.63 10.24 97 175851 31266 34749717
Venoocclusive liver disease 13.62 10.24 12 175936 7954 34773029
Wound infection 13.59 10.24 71 175877 7008 34773975
Proctalgia 13.58 10.24 61 175887 5662 34775321
Migraine 13.50 10.24 141 175807 17337 34763646
Administration site erythema 13.48 10.24 7 175941 72 34780911
Trichoglossia 13.45 10.24 12 175936 316 34780667
Cytomegalovirus infection 13.32 10.24 77 175871 26058 34754925
Peripheral swelling 13.20 10.24 289 175659 76252 34704731
Blood pressure decreased 13.13 10.24 346 175602 51169 34729814
Gastrointestinal haemorrhage 13.07 10.24 342 175606 88135 34692848
Fibrin D dimer increased 13.05 10.24 49 175899 4195 34776788
Parkinsonism 13.04 10.24 13 175935 8125 34772858
Hypoaesthesia 13.03 10.24 224 175724 61220 34719763
Systemic infection 12.95 10.24 5 175943 5207 34775776
Anti-erythrocyte antibody positive 12.95 10.24 6 175942 47 34780936
Ejection fraction decreased 12.94 10.24 51 175897 19103 34761880
Myasthenia gravis 12.91 10.24 69 175879 6871 34774112
Thrombotic microangiopathy 12.87 10.24 21 175927 10609 34770374
Foetal exposure during pregnancy 12.86 10.24 126 175822 37975 34743008
Weight increased 12.85 10.24 582 175366 92451 34688532
Illness 12.84 10.24 114 175834 13415 34767568
Brain death 12.80 10.24 36 175912 2647 34778336
Muscle spasms 12.70 10.24 284 175664 74717 34706266
Crystal urine present 12.66 10.24 14 175934 481 34780502
Environmental exposure 12.61 10.24 11 175937 281 34780702
Gait disturbance 12.60 10.24 329 175619 84811 34696172
Injection site pruritus 12.58 10.24 10 175938 6973 34774010
Chronic obstructive pulmonary disease 12.53 10.24 172 175776 48746 34732237
Pyroglutamate increased 12.51 10.24 11 175937 284 34780699
Abdominal discomfort 12.41 10.24 219 175729 59616 34721367
Protein urine 12.39 10.24 19 175929 905 34780078
Full blood count decreased 12.32 10.24 48 175900 18040 34762943
Hepatitis C 12.30 10.24 19 175929 9811 34771172
Adverse event 12.29 10.24 51 175897 18826 34762157
Electrocardiogram QRS complex prolonged 12.24 10.24 53 175895 4841 34776142
Suicidal ideation 12.23 10.24 137 175811 40251 34740732
Acute phase reaction 12.13 10.24 7 175941 90 34780893
Cardiac arrest 12.10 10.24 596 175352 95563 34685420
Testicular infarction 12.05 10.24 6 175942 56 34780927
Intraocular pressure increased 12.05 10.24 6 175942 5377 34775606
Pulmonary oedema 12.05 10.24 319 175629 47210 34733773
Hepatocellular carcinoma 12.03 10.24 12 175936 7497 34773486
BK virus infection 11.96 10.24 7 175941 5731 34775252
Acid-base balance disorder mixed 11.96 10.24 6 175942 57 34780926
Endocardial fibrosis 11.91 10.24 5 175943 30 34780953
SJS-TEN overlap 11.75 10.24 11 175937 309 34780674
Obesity 11.71 10.24 30 175918 12848 34768135
Injection site extravasation 11.69 10.24 37 175911 2905 34778078
Anion gap increased 11.68 10.24 28 175920 1868 34779115
Acute generalised exanthematous pustulosis 11.68 10.24 66 175882 6710 34774273
Renal cancer 11.68 10.24 13 175935 7722 34773261
Prostate infection 11.64 10.24 19 175929 955 34780028
Hypothermia 11.49 10.24 93 175855 10655 34770328
Incorrect dose administered 11.47 10.24 276 175672 40239 34740744
Asphyxia 11.41 10.24 66 175882 6769 34774214
Vision blurred 11.28 10.24 163 175785 45800 34735183
Infusion site discomfort 11.26 10.24 9 175939 203 34780780
Nocardiosis 11.21 10.24 3 175945 3948 34777035
Injection site haemorrhage 11.18 10.24 20 175928 9748 34771235
Product complaint 11.17 10.24 8 175940 5882 34775101
Necrotising oesophagitis 11.14 10.24 14 175934 552 34780431
Device leakage 11.13 10.24 10 175938 6565 34774418
Graft versus host disease in skin 11.10 10.24 3 175945 3922 34777061
Hyperphosphataemia 11.06 10.24 48 175900 4389 34776594
SARS-CoV-2 test negative 11.00 10.24 19 175929 1001 34779982
Bacterial test 11.00 10.24 8 175940 156 34780827
Drug reaction with eosinophilia and systemic symptoms 10.95 10.24 230 175718 32782 34748201
Disturbance in attention 10.91 10.24 81 175867 25864 34755119
Acute myeloid leukaemia 10.90 10.24 51 175897 18219 34762764
Lymphocyte count decreased 10.83 10.24 167 175781 22455 34758528
Victim of sexual abuse 10.83 10.24 3 175945 3 34780980
Loss of consciousness 10.81 10.24 325 175623 82342 34698641
Pseudomonal bacteraemia 10.71 10.24 23 175925 1426 34779557
Serum sickness 10.71 10.24 28 175920 1972 34779011
Angina unstable 10.71 10.24 27 175921 11626 34769357
Ventricular tachycardia 10.70 10.24 84 175864 26495 34754488
Pemphigoid 10.60 10.24 17 175931 8649 34772334
Bronchial dysplasia 10.59 10.24 5 175943 41 34780942
Injection site bruising 10.59 10.24 17 175931 8646 34772337
Fungal rhinitis 10.49 10.24 5 175943 42 34780941
Dermatitis atopic 10.49 10.24 7 175941 5340 34775643
Acidosis hyperchloraemic 10.43 10.24 12 175936 431 34780552
Vessel puncture site bruise 10.39 10.24 5 175943 43 34780940
Hyperplastic cholecystopathy 10.39 10.24 5 175943 43 34780940
Anaphylactic reaction 10.38 10.24 224 175724 32077 34748906
Transfusion-related circulatory overload 10.33 10.24 10 175938 293 34780690
Treatment noncompliance 10.31 10.24 91 175857 28009 34752974
Ultrasound liver abnormal 10.29 10.24 7 175941 122 34780861
Therapeutic response unexpected 10.27 10.24 21 175927 9736 34771247
Status epilepticus 10.27 10.24 31 175917 12583 34768400
Administration site pain 10.25 10.24 10 175938 296 34780687

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3654.86 9.93 6194 530825 239573 78967796
Toxicity to various agents 3353.34 9.93 8190 528829 413350 78794019
Exposure to toxic agent 1431.65 9.93 846 536173 8312 79199057
Infusion related reaction 1245.65 9.93 3892 533127 226345 78981024
Blood pressure fluctuation 886.73 9.93 1609 535410 65536 79141833
Acute hepatic failure 784.64 9.93 991 536028 29122 79178247
Intentional overdose 769.15 9.93 1993 535026 103967 79103402
Overdose 685.08 9.93 2754 534265 181452 79025917
Intentional product misuse 679.41 9.93 1779 535240 93386 79113983
Rheumatoid arthritis 445.32 9.93 2660 534359 205810 79001559
Hepatic cytolysis 428.20 9.93 704 536315 26447 79180922
Duodenal ulcer perforation 384.98 9.93 1149 535870 65062 79142307
Muscle injury 381.99 9.93 942 536077 47619 79159750
Metabolic acidosis 376.42 9.93 1318 535701 81211 79126158
Heart rate decreased 369.58 9.93 1178 535841 69138 79138231
Helicobacter infection 365.68 9.93 1167 535852 68537 79138832
Sinusitis 353.33 9.93 2391 534628 193110 79014259
Folliculitis 351.77 9.93 992 536027 54388 79152981
Product dose omission issue 340.01 9.93 724 536295 246813 78960556
Hepatotoxicity 338.14 9.93 932 536087 50420 79156949
Analgesic drug level increased 335.23 9.93 229 536790 2949 79204420
Irritable bowel syndrome 332.84 9.93 1049 535970 61192 79146177
Anti-cyclic citrullinated peptide antibody positive 330.51 9.93 1270 535749 81873 79125496
Intentional product use issue 312.62 9.93 1922 535097 150190 79057179
Sleep disorder due to general medical condition, insomnia type 307.37 9.93 811 536208 42745 79164624
Hepatic enzyme increased 305.60 9.93 2192 534827 180418 79026951
Blood pressure increased 298.90 9.93 2439 534580 208921 78998448
Injection site pain 294.56 9.93 264 536755 129574 79077795
Pemphigus 292.04 9.93 1387 535632 98195 79109174
Anion gap 290.81 9.93 182 536837 1999 79205370
Pericarditis 286.43 9.93 1425 535594 102811 79104558
Hand deformity 284.38 9.93 1419 535600 102500 79104869
Medication error 278.15 9.93 1055 535964 67587 79139782
Lower respiratory tract infection 275.17 9.93 1648 535371 127572 79079797
Nasopharyngitis 267.26 9.93 2749 534270 251132 78956237
Glossodynia 244.21 9.93 1355 535664 101982 79105387
Blood pressure diastolic abnormal 243.07 9.93 452 536567 18750 79188619
Myocardial infarction 242.49 9.93 551 536468 183578 79023791
Blister 240.63 9.93 1502 535517 117974 79089395
Anaemia 236.73 9.93 1890 535129 443125 78764244
Cardiac failure congestive 234.07 9.93 373 536646 142029 79065340
Blood pressure systolic increased 231.71 9.93 980 536039 66006 79141363
Wound 230.52 9.93 1455 535564 114724 79092645
Ill-defined disorder 230.39 9.93 967 536052 64908 79142461
Suicide attempt 229.40 9.93 1136 535883 81796 79125573
Blood pressure systolic abnormal 222.10 9.93 409 536610 16838 79190531
Systemic lupus erythematosus 220.10 9.93 1484 535535 119665 79087704
Discomfort 215.94 9.93 1518 535501 124099 79083270
Coagulopathy 215.11 9.93 631 536388 35375 79171994
Diarrhoea 212.14 9.93 4423 532596 876066 78331303
Depressed level of consciousness 202.11 9.93 1227 535792 95425 79111944
Impaired healing 200.88 9.93 1140 535879 86515 79120854
Synovitis 200.49 9.93 1716 535303 149018 79058351
Injection site erythema 193.44 9.93 146 536873 78051 79129318
Blood pressure diastolic decreased 192.58 9.93 542 536477 29674 79177695
Drug interaction 190.74 9.93 1831 535188 413352 78794017
Weight increased 190.48 9.93 2771 534248 274615 78932754
Oxygen saturation decreased 189.81 9.93 1503 535516 127544 79079825
Wrong technique in product usage process 178.84 9.93 141 536878 73734 79133635
Poisoning deliberate 177.31 9.93 392 536627 18436 79188933
Joint swelling 170.09 9.93 2810 534209 285836 78921533
Cardiac failure 166.83 9.93 512 536507 154330 79053039
Drug resistance 163.94 9.93 41 536978 42172 79165197
Drug ineffective 161.87 9.93 5808 531211 1075105 78132264
Body temperature increased 159.96 9.93 658 536361 43762 79163607
Pyroglutamic acidosis 159.31 9.93 96 536923 980 79206389
Sedation complication 157.57 9.93 335 536684 15334 79192035
Throat irritation 155.79 9.93 617 536402 40329 79167040
Liver injury 153.35 9.93 771 536248 55843 79151526
Hepatic necrosis 150.32 9.93 241 536778 8859 79198510
Cytokine release syndrome 147.22 9.93 555 536464 35443 79171926
Arthropathy 146.92 9.93 1831 535188 175280 79032089
Poisoning 143.48 9.93 435 536584 24837 79182532
Cardio-respiratory arrest 142.50 9.93 1232 535787 107278 79100091
Therapeutic product effect decreased 141.52 9.93 1707 535312 162156 79045213
Swelling 139.76 9.93 2142 534877 214569 78992800
Respiratory arrest 138.84 9.93 759 536260 56791 79150578
Device expulsion 138.52 9.93 9 537010 25852 79181517
Respiratory depression 133.55 9.93 450 536569 27180 79180189
Creatinine renal clearance decreased 130.17 9.93 350 536669 18652 79188717
Suspected suicide 127.70 9.93 244 536775 10332 79197037
Gastrointestinal disorder 126.39 9.93 1319 535700 120886 79086483
Psoriasis 123.72 9.93 261 536758 89326 79118043
Renal impairment 122.15 9.93 596 536423 157187 79050182
Disease progression 121.47 9.93 735 536284 183627 79023742
Heart rate irregular 120.77 9.93 488 536531 32191 79175178
COVID-19 119.77 9.93 1604 535415 156070 79051299
Bone marrow failure 118.17 9.93 102 536917 51005 79156364
Contraindicated product administered 114.91 9.93 1591 535428 155947 79051422
Coma 114.51 9.93 1108 535911 99541 79107828
Blood pressure diastolic increased 113.17 9.93 281 536738 14261 79193108
Pancytopenia 112.24 9.93 655 536364 165090 79042279
Accidental overdose 112.14 9.93 546 536473 39035 79168334
Blood calcium decreased 111.94 9.93 468 536551 31351 79176018
Malignant neoplasm progression 110.36 9.93 505 536514 135485 79071884
Coronary artery disease 109.92 9.93 169 536850 65305 79142064
Injection site pruritus 108.40 9.93 76 536943 42207 79165162
Heart rate increased 108.34 9.93 1267 535752 119457 79087912
Osteonecrosis of jaw 107.81 9.93 80 536939 43146 79164223
Hypersensitivity 107.25 9.93 2415 534604 259824 78947545
Body temperature decreased 104.77 9.93 462 536557 31683 79175686
Rheumatic fever 104.64 9.93 425 536594 28100 79179269
Injection site bruising 103.41 9.93 75 536944 40927 79166442
Interstitial lung disease 103.21 9.93 399 536620 112201 79095168
Injection site reaction 101.32 9.93 132 536887 54653 79152716
Poor venous access 99.86 9.93 309 536710 17840 79189529
Injection site swelling 99.65 9.93 102 536917 47030 79160339
Sopor 99.23 9.93 49 536970 32961 79174408
Neutropenia 99.00 9.93 1353 535666 286357 78921012
Cerebrovascular accident 98.70 9.93 626 536393 154666 79052703
Hepatic failure 95.53 9.93 723 536296 60489 79146880
Dyspnoea 91.61 9.93 4779 532240 852246 78355123
Decreased appetite 89.56 9.93 1695 535324 340723 78866646
Dehydration 89.42 9.93 1156 535863 247031 78960338
Hospitalisation 88.25 9.93 331 536688 93905 79113464
Inappropriate schedule of product administration 88.09 9.93 1326 535693 132302 79075067
Acute lung injury 87.12 9.93 106 536913 2994 79204375
Dizziness 85.70 9.93 2797 534222 523644 78683725
Therapy cessation 84.40 9.93 77 536942 37485 79169884
Rheumatoid factor positive 84.15 9.93 690 536329 59149 79148220
Exposure via ingestion 84.06 9.93 136 536883 5038 79202331
Infusion site extravasation 83.64 9.93 200 536819 9908 79197461
Hypotension 81.31 9.93 3684 533335 436633 78770736
Atrial fibrillation 79.93 9.93 899 536120 196987 79010382
Product prescribing error 78.80 9.93 112 536907 44701 79162668
Infusion site pain 78.59 9.93 242 536777 13934 79193435
Anion gap abnormal 78.39 9.93 51 536968 602 79206767
Acute myocardial infarction 77.86 9.93 262 536757 76774 79130595
Myelosuppression 76.68 9.93 95 536924 40201 79167168
Stomatitis 74.61 9.93 1396 535623 145361 79062008
Ear pain 73.64 9.93 425 536594 32444 79174925
Gastrointestinal haemorrhage 72.18 9.93 641 536378 147078 79060291
Neuropathy peripheral 71.79 9.93 607 536412 140698 79066671
Swollen joint count increased 71.32 9.93 325 536694 22602 79184767
Renal failure 70.20 9.93 942 536077 200026 79007343
Diabetes mellitus 69.14 9.93 282 536737 78108 79129261
Syncope 69.06 9.93 824 536195 178625 79028744
Therapeutic product effect incomplete 69.05 9.93 615 536404 141030 79066339
Feeling abnormal 68.39 9.93 713 536306 158486 79048883
Substance abuse 68.23 9.93 190 536829 10336 79197033
Hyperkalaemia 66.74 9.93 473 536546 113925 79093444
Cerebral infarction 66.53 9.93 129 536890 45547 79161822
Arthralgia 66.11 9.93 4583 532436 567220 78640149
Therapeutic response shortened 66.04 9.93 246 536773 15617 79191752
Product substitution issue 65.69 9.93 27 536992 20229 79187140
Hyperlipidaemia 65.44 9.93 48 536971 26045 79181324
Alanine aminotransferase increased 64.79 9.93 1492 535527 161078 79046291
Oedema peripheral 64.64 9.93 1253 535766 251035 78956334
Neoplasm progression 64.51 9.93 159 536860 51523 79155846
Sedation 64.37 9.93 582 536437 51313 79156056
Visual acuity reduced 64.34 9.93 62 536957 29407 79177962
Drug abuse 62.96 9.93 1487 535532 161204 79046165
Infusion site swelling 62.78 9.93 153 536866 7673 79199696
Prostate cancer 62.71 9.93 79 536940 33189 79174180
Ear pruritus 62.59 9.93 105 536914 4010 79203359
Loss of consciousness 62.41 9.93 777 536242 167166 79040203
Dyspnoea exertional 61.67 9.93 339 536680 86734 79120635
Product quality issue 61.51 9.93 83 536936 33857 79173512
Acute kidney injury 61.22 9.93 2866 534153 516538 78690831
Infusion site pruritus 61.21 9.93 104 536915 4014 79203355
Respiratory rate increased 61.21 9.93 298 536721 21302 79186067
Pyroglutamate increased 59.05 9.93 44 536975 655 79206714
Drug intolerance 58.96 9.93 2255 534764 261864 78945505
Leukopenia 58.95 9.93 501 536518 116012 79091357
Urine abnormality 58.95 9.93 154 536865 8065 79199304
Neutrophil percentage increased 58.87 9.93 110 536909 4579 79202790
Mobility decreased 58.61 9.93 1152 535867 121023 79086346
Full blood count abnormal 58.35 9.93 115 536904 40359 79167010
Injection site warmth 58.24 9.93 14 537005 14793 79192576
Contusion 58.23 9.93 1362 535657 147414 79059955
Transient ischaemic attack 57.60 9.93 173 536846 52522 79154847
Pneumonia 57.38 9.93 3754 533265 656492 78550877
Electric shock 57.01 9.93 58 536961 1336 79206033
Unevaluable event 56.88 9.93 188 536831 55397 79151972
Haematotoxicity 56.64 9.93 17 537002 15502 79191867
Septic shock 56.47 9.93 541 536478 122260 79085109
Urine leukocyte esterase positive 56.47 9.93 100 536919 3991 79203378
Body temperature fluctuation 56.39 9.93 96 536923 3711 79203658
Underdose 56.19 9.93 85 536934 33066 79174303
Epistaxis 55.75 9.93 481 536538 111034 79096335
Cerebral haemorrhage 55.68 9.93 200 536819 57473 79149896
Cognitive disorder 55.41 9.93 717 536302 69209 79138160
Thrombocytopenia 55.38 9.93 1361 535658 263898 78943471
Product storage error 55.32 9.93 20 536999 16206 79191163
Alopecia 55.19 9.93 1990 535029 229365 78978004
Crystal urine present 54.53 9.93 70 536949 2090 79205279
Cytomegalovirus infection 54.17 9.93 130 536889 42514 79164855
Labelled drug-drug interaction medication error 53.87 9.93 64 536955 27586 79179783
Device issue 53.61 9.93 62 536957 27046 79180323
Injection site rash 53.44 9.93 27 536992 17927 79189442
Palmar-plantar erythrodysaesthesia syndrome 53.27 9.93 88 536931 33046 79174323
Weight fluctuation 52.80 9.93 186 536833 11489 79195880
Injection site haemorrhage 52.72 9.93 66 536953 27804 79179565
Fibromyalgia 52.36 9.93 663 536356 63677 79143692
Posterior reversible encephalopathy syndrome 52.09 9.93 60 536959 26221 79181148
Maternal exposure during pregnancy 51.92 9.93 1245 535774 135293 79072076
White blood cells urine positive 51.13 9.93 121 536898 5954 79201415
Oesophageal carcinoma 51.08 9.93 7 537012 11077 79196292
Infusion site erythema 51.06 9.93 160 536859 9300 79198069
Diabetic ketoacidosis 50.89 9.93 95 536924 34027 79173342
Immune reconstitution inflammatory syndrome 50.81 9.93 15 537004 13826 79193543
Pathogen resistance 50.06 9.93 17 537002 14325 79193044
Surgery 49.96 9.93 90 536929 32676 79174693
Muscle spasticity 48.97 9.93 279 536740 21196 79186173
Lymphocyte percentage decreased 48.44 9.93 105 536914 4871 79202498
Orthostatic hypotension 48.40 9.93 585 536434 55579 79151790
Platelet count decreased 48.27 9.93 972 536047 193692 79013677
Injection site mass 48.24 9.93 39 536980 20145 79187224
Myelodysplastic syndrome 48.23 9.93 81 536938 30220 79177149
Peripheral swelling 48.20 9.93 2249 534770 267368 78940001
Vision blurred 47.65 9.93 469 536550 105429 79101940
Hypocalcaemia 47.62 9.93 174 536845 49750 79157619
Electrocardiogram QT prolonged 47.38 9.93 385 536634 90001 79117368
Post transplant lymphoproliferative disorder 46.77 9.93 10 537009 11454 79195915
Asthenia 46.69 9.93 2896 534123 508793 78698576
Deep vein thrombosis 46.60 9.93 555 536464 120364 79087005
Device difficult to use 46.48 9.93 16 537003 13369 79194000
Bladder cancer 46.33 9.93 38 536981 19488 79187881
Muscle spasms 45.90 9.93 864 536155 173866 79033503
Red blood cell sedimentation rate abnormal 45.89 9.93 44 536975 20919 79186450
White blood cell count decreased 45.84 9.93 943 536076 187345 79020024
Paraesthesia 45.05 9.93 876 536143 175447 79031922
Cardiac failure chronic 44.84 9.93 10 537009 11125 79196244
Haematuria 44.48 9.93 276 536743 68560 79138809
Bursitis 44.45 9.93 402 536617 35442 79171927
Respiratory failure 44.06 9.93 906 536113 180005 79027364
Drug use disorder 43.67 9.93 143 536876 8508 79198861
Osteonecrosis 43.42 9.93 90 536929 31005 79176364
Systemic infection 43.00 9.93 7 537012 9745 79197624
Device malfunction 42.48 9.93 49 536970 21399 79185970
Drug-induced liver injury 42.35 9.93 653 536366 65464 79141905
Pharyngeal paraesthesia 42.15 9.93 70 536949 2651 79204718
Night sweats 42.04 9.93 536 536483 51559 79155810
Anticipatory anxiety 41.96 9.93 46 536973 1158 79206211
Therapy interrupted 41.86 9.93 93 536926 31248 79176121
Joint range of motion decreased 41.65 9.93 374 536645 32908 79174461
Depression 41.59 9.93 1126 535893 215664 78991705
Jaundice cholestatic 41.28 9.93 168 536851 11116 79196253
Thrombotic microangiopathy 41.12 9.93 45 536974 20124 79187245
Acute myeloid leukaemia 40.96 9.93 92 536927 30793 79176576
Sexual dysfunction 40.71 9.93 3 537016 7760 79199609
Infusion site bruising 40.54 9.93 72 536947 2880 79204489
Unintentional medical device removal 40.38 9.93 3 537016 7709 79199660
Dry skin 40.21 9.93 280 536739 67715 79139654
Hypomania 40.17 9.93 127 536892 7417 79199952
Mucosal inflammation 40.04 9.93 321 536698 75259 79132110
Blood pH decreased 39.83 9.93 94 536925 4617 79202752
Seizure 39.63 9.93 968 536051 187866 79019503
Facet joint syndrome 39.57 9.93 166 536853 11136 79196233
Fall 39.54 9.93 2789 534230 484840 78722529
Blood parathyroid hormone decreased 39.45 9.93 11 537008 10525 79196844
Injection site induration 39.18 9.93 9 537010 9810 79197559
Gait disturbance 38.97 9.93 1081 535938 206425 79000944
Cardiac failure acute 38.85 9.93 42 536977 18887 79188482
Lymphocyte count decreased 38.78 9.93 488 536531 46801 79160568
Injection site urticaria 38.61 9.93 19 537000 12807 79194562
Pain 38.44 9.93 5353 531666 698449 78508920
Tremor 38.16 9.93 863 536156 169220 79038149
Status epilepticus 37.98 9.93 69 536950 24972 79182397
Full blood count decreased 37.97 9.93 77 536942 26742 79180627
Second primary malignancy 37.84 9.93 25 536994 14325 79193044
Basal cell carcinoma 37.84 9.93 127 536892 37248 79170121
Aspergillus infection 37.70 9.93 44 536975 19117 79188252
Urinary sediment present 37.65 9.93 64 536955 2471 79204898
Multiple-drug resistance 37.36 9.93 7 537012 8801 79198568
Cytopenia 36.78 9.93 50 536969 20333 79187036
Confusional state 36.68 9.93 2549 534470 315448 78891921
Urticaria 36.62 9.93 1561 535458 183640 79023729
Drug ineffective for unapproved indication 36.54 9.93 199 536820 51039 79156330
Infection 36.34 9.93 1983 535036 239729 78967640
Ventricular tachycardia 36.26 9.93 152 536867 41783 79165586
Abdominal discomfort 35.94 9.93 2048 534971 248679 78958690
Myalgia 35.92 9.93 963 536056 184678 79022691
Nausea 35.63 9.93 5784 531235 951412 78255957
Hypokalaemia 35.47 9.93 720 536299 143320 79064049
Aspartate aminotransferase increased 35.39 9.93 1202 535817 137439 79069930
Specific gravity urine decreased 34.95 9.93 36 536983 842 79206527
Pulmonary embolism 34.92 9.93 884 536135 170770 79036599
Blood cholesterol increased 34.79 9.93 773 536246 82947 79124422
Epilepsy 34.78 9.93 149 536870 40711 79166658
Memory impairment 34.68 9.93 536 536483 111198 79096171
Angina unstable 34.67 9.93 36 536983 16491 79190878
Infusion site mass 34.65 9.93 48 536971 1545 79205824
Thinking abnormal 34.61 9.93 23 536996 13138 79194231
No adverse event 34.57 9.93 131 536888 37061 79170308
Haemorrhage 34.42 9.93 420 536599 90698 79116671
Multiple drug therapy 34.08 9.93 81 536938 3997 79203372
Breast cancer stage I 33.99 9.93 3 537016 6697 79200672
Sudden infant death syndrome 33.58 9.93 22 536997 263 79207106
Graft versus host disease 33.52 9.93 31 536988 14995 79192374
Renal cortical necrosis 33.45 9.93 24 536995 336 79207033
Blood glucose increased 33.21 9.93 559 536460 114416 79092953
Deep vein thrombosis postoperative 33.13 9.93 152 536867 10600 79196769
Pulmonary hypertension 33.06 9.93 189 536830 47891 79159478
Acidosis 32.86 9.93 237 536782 19525 79187844
Incorrect drug administration rate 32.60 9.93 79 536940 3947 79203422
Spinal stenosis 32.45 9.93 35 536984 15756 79191613
Suicidal ideation 32.32 9.93 343 536676 75997 79131372
Anion gap increased 32.30 9.93 75 536944 3645 79203724
Endophthalmitis 32.28 9.93 3 537016 6425 79200944
Therapeutic response unexpected 32.04 9.93 53 536966 19893 79187476
Cardiac disorder 31.81 9.93 286 536733 65471 79141898
Granuloma skin 31.80 9.93 11 537008 9163 79198206
Dermatitis atopic 31.65 9.93 14 537005 10042 79197327
Disturbance in attention 31.63 9.93 206 536813 50595 79156774
Forced expiratory volume decreased 31.50 9.93 7 537012 7807 79199562
Renal cancer 31.30 9.93 22 536997 12204 79195165
Iron deficiency anaemia 31.24 9.93 80 536939 25592 79181777
International normalised ratio increased 31.13 9.93 769 536250 83952 79123417
Lactic acidosis 31.07 9.93 313 536706 70046 79137323
Appendicolith 31.04 9.93 127 536892 8424 79198945
Subdural haematoma 31.01 9.93 108 536911 31326 79176043
Hypertensive crisis 30.82 9.93 58 536961 20712 79186657
Wound infection 30.74 9.93 271 536748 23720 79183649
Asthma 30.72 9.93 684 536335 134411 79072958
Brain death 30.62 9.93 96 536923 5581 79201788
Drug hypersensitivity 30.40 9.93 1674 535345 297242 78910127
Hyponatraemia 30.26 9.93 939 536080 176909 79030460
Chronic kidney disease 30.17 9.93 292 536727 65862 79141507
Akathisia 30 9.93 27 536992 13232 79194137
Lip dry 29.87 9.93 192 536827 15226 79192143
Rash pruritic 29.85 9.93 323 536696 71306 79136063
Pulmonary arterial hypertension 29.67 9.93 95 536924 28271 79179098
Right ventricular failure 29.55 9.93 72 536947 23425 79183944
Fixed eruption 29.52 9.93 63 536956 2891 79204478
Drug withdrawal syndrome 29.31 9.93 127 536892 34591 79172778
Device dislocation 29.30 9.93 84 536935 25886 79181483
Hallucination 29.16 9.93 404 536615 85341 79122028
Lung neoplasm malignant 29.13 9.93 93 536926 27699 79179670
Diplopia 29.12 9.93 121 536898 33345 79174024
Infusion site haemorrhage 29.07 9.93 72 536947 3648 79203721
Breast cancer female 28.85 9.93 21 536998 11440 79195929
Hypomagnesaemia 28.82 9.93 191 536828 46720 79160649
Skin exfoliation 28.73 9.93 235 536784 54865 79152504
Hepatic cirrhosis 28.67 9.93 129 536890 34777 79172592
Product monitoring error 28.67 9.93 12 537007 8894 79198475
Hypercalcaemia 28.66 9.93 147 536872 38283 79169086
Neurotoxicity 28.66 9.93 117 536902 32401 79174968
Panniculitis 28.22 9.93 25 536994 12346 79195023
Extrapyramidal disorder 28.12 9.93 70 536949 22609 79184760
Pain in extremity 28.05 9.93 2094 534925 362444 78844925
Withdrawal syndrome 28.05 9.93 90 536929 26764 79180605
Haematochezia 28.03 9.93 418 536601 87227 79120142
Anti-cyclic citrullinated peptide antibody 28.00 9.93 95 536924 5757 79201612
SARS-CoV-2 test positive 27.90 9.93 154 536865 11562 79195807
Pruritus 27.78 9.93 3050 533969 391598 78815771
Dysarthria 27.75 9.93 306 536713 67316 79140053
Maternal exposure timing unspecified 27.69 9.93 94 536925 5698 79201671
Mitral valve incompetence 27.61 9.93 99 536920 28466 79178903
Speech disorder 27.58 9.93 234 536785 54211 79153158
Myopathy 27.47 9.93 61 536958 20502 79186867
Pneumocystis jirovecii pneumonia 27.39 9.93 119 536900 32389 79174980
Abortion spontaneous 27.38 9.93 104 536915 29403 79177966
Transplant rejection 27.35 9.93 56 536963 19381 79187988
Intervertebral discitis 27.30 9.93 83 536936 4745 79202624
Skin necrosis 27.29 9.93 50 536969 18037 79189332
Colorectal cancer 27.28 9.93 12 537007 8635 79198734
Drug level below therapeutic 27.11 9.93 134 536885 9636 79197733
Acute respiratory failure 27.07 9.93 263 536756 59278 79148091
Analgesic drug level above therapeutic 26.96 9.93 24 536995 465 79206904
Product use in unapproved indication 26.96 9.93 1394 535625 248965 78958404
Toxic epidermal necrolysis 26.92 9.93 436 536583 44145 79163224
Bilirubin urine present 26.92 9.93 21 536998 336 79207033
Prothrombin time shortened 26.85 9.93 64 536955 3164 79204205
Red blood cells urine positive 26.84 9.93 84 536935 4879 79202490
Multiple sclerosis relapse 26.84 9.93 193 536826 46340 79161029
Fluid retention 26.66 9.93 321 536698 69488 79137881
Congestive cardiomyopathy 26.64 9.93 24 536995 11756 79195613
Prothrombin time prolonged 26.58 9.93 200 536819 16699 79190670
Oral pruritus 26.56 9.93 54 536965 2394 79204975
Gastric cancer 26.48 9.93 18 537001 10161 79197208
Therapeutic response decreased 26.46 9.93 305 536714 66548 79140821
Drug dose omission by device 26.44 9.93 5 537014 6245 79201124
Bone pain 26.29 9.93 244 536775 55498 79151871
Thrombosis 25.91 9.93 404 536615 83696 79123673
Hepatitis acute 25.62 9.93 186 536833 15356 79192013
Visual impairment 25.61 9.93 451 536568 91680 79115689
Chronic graft versus host disease 25.54 9.93 7 537012 6774 79200595
Renal papillary necrosis 25.51 9.93 22 536997 408 79206961
Graft versus host disease in skin 25.39 9.93 5 537014 6068 79201301
Musculoskeletal stiffness 25.35 9.93 1431 535588 173577 79033792
Bacterial test 25.34 9.93 36 536983 1187 79206182
Generalised bullous fixed drug eruption 25.32 9.93 16 537003 179 79207190
Gynaecomastia 25.29 9.93 10 537009 7671 79199698
Sputum culture positive 25.25 9.93 69 536950 3712 79203657
Coronary arterial stent insertion 25.22 9.93 5 537014 6039 79201330
Clostridium test positive 25.15 9.93 98 536921 6356 79201013
Tricuspid valve incompetence 25.11 9.93 60 536959 19652 79187717
Concomitant disease aggravated 25.09 9.93 31 536988 13136 79194233
Ageusia 25.07 9.93 46 536973 16586 79190783
Metastases to lymph nodes 24.96 9.93 20 536999 10377 79196992
Hypothyroidism 24.85 9.93 229 536790 52163 79155206
Device leakage 24.69 9.93 22 536997 10834 79196535
Cytomegalovirus viraemia 24.63 9.93 30 536989 12791 79194578
Pyrexia 24.62 9.93 5051 531968 673658 78533711
Multiple allergies 24.58 9.93 137 536882 10323 79197046
Red blood cell sedimentation rate 24.53 9.93 4 537015 5561 79201808
Blood triglycerides increased 24.52 9.93 67 536952 20973 79186396
Polyneuropathy 24.49 9.93 82 536937 24069 79183300
Transplant dysfunction 24.45 9.93 9 537010 7212 79200157
Chronic obstructive pulmonary disease 24.44 9.93 416 536603 85003 79122366
Torsade de pointes 24.42 9.93 59 536960 19253 79188116
Brain stem glioma 24.37 9.93 16 537003 192 79207177
Hypothermia 24.20 9.93 247 536772 22499 79184870
Blood loss anaemia 24.14 9.93 42 536977 15456 79191913
Hepatic encephalopathy 24.10 9.93 259 536760 23907 79183462
Adjustment disorder with depressed mood 24.08 9.93 123 536896 8963 79198406
Skin toxicity 24.01 9.93 13 537006 8301 79199068
Pleural effusion 23.97 9.93 770 536249 144492 79062877
Urine analysis abnormal 23.80 9.93 97 536922 6423 79200946
Diffuse large B-cell lymphoma 23.79 9.93 28 536991 12121 79195248
Bronchopulmonary aspergillosis 23.79 9.93 74 536945 22220 79185149
Dyskinesia 23.79 9.93 190 536829 44583 79162786
Neuroleptic malignant syndrome 23.76 9.93 100 536919 27459 79179910
Flushing 23.73 9.93 770 536249 87498 79119871
Prostatic specific antigen increased 23.68 9.93 21 536998 10365 79197004
Type 2 diabetes mellitus 23.60 9.93 527 536492 56595 79150774
Hepatocellular carcinoma 23.41 9.93 16 537003 9005 79198364
Prothrombin time ratio decreased 23.39 9.93 30 536989 895 79206474
Hepatitis fulminant 23.38 9.93 104 536915 7158 79200211
Metastases to lung 23.36 9.93 55 536964 18108 79189261
Incorrect dose administered by device 23.35 9.93 3 537016 4986 79202383
Soft tissue disorder 23.33 9.93 64 536955 3451 79203918
Vital capacity decreased 23.30 9.93 43 536976 1773 79205596
Osmolar gap 23.28 9.93 15 537004 174 79207195
Infusion site discomfort 23.27 9.93 37 536982 1350 79206019
Haemolysis 23.27 9.93 157 536862 12655 79194714
Hypertriglyceridaemia 23.24 9.93 31 536988 12709 79194660
Disturbance in social behaviour 23.23 9.93 3 537016 4967 79202402
Hepatic cancer 23.16 9.93 22 536997 10507 79196862
Nocardiosis 23.07 9.93 5 537014 5674 79201695
Glycosylated haemoglobin increased 22.69 9.93 61 536958 19199 79188170
Acute graft versus host disease 22.65 9.93 21 536998 10146 79197223
Red cell distribution width increased 22.64 9.93 178 536841 15064 79192305
Pain in jaw 22.64 9.93 200 536819 45951 79161418
Electrolyte imbalance 22.54 9.93 119 536900 30762 79176607
COVID-19 pneumonia 22.51 9.93 295 536724 28554 79178815
Treatment noncompliance 22.46 9.93 234 536785 52034 79155335
Mydriasis 22.45 9.93 199 536820 17444 79189925
Carotid artery stenosis 22.11 9.93 16 537003 8742 79198627
Bundle branch block left 22.05 9.93 27 536992 11486 79195883
Loss of personal independence in daily activities 22.01 9.93 524 536495 102056 79105313
White coat hypertension 21.92 9.93 28 536991 832 79206537
Transaminases increased 21.89 9.93 479 536540 51264 79156105
Aplastic anaemia 21.79 9.93 200 536819 17705 79189664
Cystitis haemorrhagic 21.58 9.93 18 537001 9154 79198215
Aggression 21.55 9.93 229 536790 50729 79156640
Hypocoagulable state 21.52 9.93 46 536973 2113 79205256
Cardiomyopathy 21.50 9.93 110 536909 28664 79178705
Coronary artery bypass 21.48 9.93 7 537012 6055 79201314
Autoimmune disorder 21.47 9.93 188 536831 16424 79190945
Aplasia pure red cell 21.43 9.93 13 537006 7797 79199572
Melaena 21.38 9.93 285 536734 60605 79146764
Methaemoglobinaemia 21.34 9.93 84 536935 5473 79201896
Hip arthroplasty 21.33 9.93 349 536670 35407 79171962
Ischaemic stroke 21.32 9.93 133 536886 32998 79174371
Metastases to liver 21.29 9.93 108 536911 28206 79179163
Brain oedema 20.84 9.93 261 536758 25002 79182367
Genital haemorrhage 20.84 9.93 8 537011 6247 79201122
Lymphoproliferative disorder 20.77 9.93 6 537013 5609 79201760
Epstein-Barr virus infection 20.74 9.93 41 536978 14375 79192994
Skin burning sensation 20.64 9.93 36 536983 13236 79194133
Angina pectoris 20.48 9.93 236 536783 51496 79155873
Injection site discolouration 20.44 9.93 13 537006 7601 79199768
Renal disorder 20.42 9.93 183 536836 41922 79165447
COVID-19 immunisation 20.36 9.93 35 536984 1364 79206005
Ketoacidosis 20.28 9.93 14 537005 7840 79199529
Skin lesion 20.24 9.93 182 536837 41662 79165707
Death 20.22 9.93 4213 532806 562301 78645068
Blood urine present 20.20 9.93 226 536793 21071 79186298
Low density lipoprotein increased 20.18 9.93 17 537002 8605 79198764
Fracture 20.13 9.93 77 536942 21724 79185645
Venoocclusive liver disease 20.12 9.93 30 536989 11741 79195628
Blood potassium decreased 20.08 9.93 208 536811 46304 79161065
Pancreatic carcinoma 20.07 9.93 38 536981 13539 79193830
Hepatitis B reactivation 20.04 9.93 8 537011 6100 79201269
Tardive dyskinesia 20.03 9.93 25 536994 10546 79196823
Varicella zoster virus infection 20.01 9.93 3 537016 4438 79202931
Erectile dysfunction 20.00 9.93 43 536976 14621 79192748
Macular oedema 19.97 9.93 6 537013 5468 79201901
Sensitivity to weather change 19.93 9.93 15 537004 8032 79199337
Lymphadenopathy 19.89 9.93 246 536773 53001 79154368
Sepsis 19.87 9.93 1553 535466 267875 78939494
Unresponsive to stimuli 19.79 9.93 504 536515 55284 79152085
Ear infection 19.78 9.93 334 536685 34098 79173271
Aphasia 19.76 9.93 210 536809 46522 79160847
Exposure to SARS-CoV-2 19.75 9.93 43 536976 2001 79205368
Fear of injection 19.74 9.93 13 537006 7461 79199908
Consciousness fluctuating 19.68 9.93 42 536977 1927 79205442
Actinic keratosis 19.68 9.93 8 537011 6034 79201335
Mixed liver injury 19.67 9.93 102 536917 7476 79199893
Cerebral ischaemia 19.66 9.93 28 536991 11167 79196202
Paradoxical drug reaction 19.66 9.93 12 537007 7173 79200196
Inflammation 19.61 9.93 795 536224 92958 79114411
Liver transplant 19.60 9.93 70 536949 4353 79203016
Sinus node dysfunction 19.53 9.93 14 537005 7687 79199682
Fungal rhinitis 19.52 9.93 10 537009 72 79207297
Ischaemic cardiomyopathy 19.50 9.93 14 537005 7681 79199688
Gestational diabetes 19.44 9.93 9 537010 6284 79201085
Acute graft versus host disease in skin 19.32 9.93 14 537005 7644 79199725
Lipodystrophy acquired 19.31 9.93 3 537016 4322 79203047
Large intestine polyp 19.29 9.93 35 536984 12673 79194696
Product complaint 19.18 9.93 38 536981 13311 79194058
Chest pain 19.18 9.93 1638 535381 280666 78926703
Peripheral venous disease 19.00 9.93 177 536842 15732 79191637
Obstructive airways disorder 18.87 9.93 129 536890 31330 79176039
Granulomatosis with polyangiitis 18.79 9.93 52 536967 2818 79204551
Potentiating drug interaction 18.74 9.93 19 537000 8800 79198569
BK virus infection 18.67 9.93 19 537000 8785 79198584
Arrhythmia 18.65 9.93 295 536724 60977 79146392
Kidney transplant rejection 18.62 9.93 25 536994 10221 79197148
Burning sensation 18.62 9.93 280 536739 58352 79149017
Dermatitis 18.61 9.93 77 536942 21244 79186125
Ventricular extrasystoles 18.58 9.93 69 536950 19635 79187734
Gastrooesophageal reflux disease 18.56 9.93 547 536472 103699 79103670
Immunosuppressant drug level increased 18.56 9.93 20 536999 9007 79198362
Neutrophil count decreased 18.53 9.93 486 536533 93473 79113896
Dysgeusia 18.52 9.93 272 536747 56905 79150464
Tendonitis 18.43 9.93 90 536929 23740 79183629
Emotional distress 18.40 9.93 176 536843 39793 79167576
Disease recurrence 18.34 9.93 199 536820 43910 79163459
Graft versus host disease in gastrointestinal tract 18.26 9.93 10 537009 6346 79201023
General physical health deterioration 18.25 9.93 1600 535419 273638 78933731
Dystonia 18.23 9.93 78 536941 21321 79186048
Gastritis erosive 18.20 9.93 28 536991 10819 79196550
Urine bilirubin decreased 18.14 9.93 12 537007 146 79207223
Tachycardia 18.10 9.93 1411 535608 176357 79031012
Plasma cell myeloma 18.08 9.93 251 536768 53008 79154361
Dysstasia 18.05 9.93 111 536908 27635 79179734
Acute coronary syndrome 18.02 9.93 77 536942 21056 79186313
Hepatitis C 17.96 9.93 33 536986 11892 79195477
Mania 17.84 9.93 63 536956 18197 79189172
Hypoglycaemic coma 17.77 9.93 5 537014 4755 79202614
Sleep disorder due to a general medical condition 17.75 9.93 44 536975 14233 79193136
Dyslipidaemia 17.69 9.93 32 536987 11601 79195768
Delusion 17.67 9.93 74 536945 20349 79187020
Human herpesvirus 6 infection 17.67 9.93 7 537012 5363 79202006
Smear cervix abnormal 17.66 9.93 47 536972 2489 79204880
Long QT syndrome 17.66 9.93 9 537010 5946 79201423
Left ventricular dysfunction 17.48 9.93 69 536950 19292 79188077
Drug screen positive 17.43 9.93 84 536935 5979 79201390
Blood creatinine decreased 17.41 9.93 101 536918 7724 79199645
Irritability 17.36 9.93 185 536834 40959 79166410
Infective pulmonary exacerbation of cystic fibrosis 17.27 9.93 38 536981 12813 79194556
Disorientation 17.22 9.93 308 536711 62468 79144901
Osteomyelitis 17.21 9.93 140 536879 32725 79174644
Intraocular pressure increased 17.20 9.93 22 536997 9183 79198186
Toxicologic test abnormal 17.19 9.93 32 536987 1328 79206041
Drug eruption 17.17 9.93 201 536818 43734 79163635
Nocturia 17.14 9.93 42 536977 13639 79193730
Retinal haemorrhage 17.12 9.93 18 537001 8199 79199170
Cardiovascular disorder 17.07 9.93 63 536956 17962 79189407
Dislocation of vertebra 17.07 9.93 101 536918 7779 79199590
Accidental exposure to product 17.06 9.93 132 536887 31190 79176179
Cryopyrin associated periodic syndrome 17.05 9.93 17 537002 382 79206987
Asphyxia 16.93 9.93 136 536883 11584 79195785
Allergy to chemicals 16.90 9.93 47 536972 2555 79204814
Circulatory collapse 16.86 9.93 167 536852 37501 79169868
Anal fissure 16.86 9.93 99 536920 7604 79199765
Somnolence 16.79 9.93 1847 535172 237134 78970235
Product use issue 16.79 9.93 1636 535383 208186 78999183
Carpal tunnel syndrome 16.75 9.93 71 536948 19457 79187912
Abnormal loss of weight 16.73 9.93 19 537000 8357 79199012
JC virus infection 16.64 9.93 3 537016 3878 79203491
Palpitations 16.63 9.93 690 536329 125920 79081449
Cardiotoxicity 16.60 9.93 36 536983 12203 79195166
Uterine perforation 16.59 9.93 11 537008 6292 79201077
Schizophrenia 16.59 9.93 168 536851 15272 79192097
Aortic valve incompetence 16.57 9.93 24 536995 9506 79197863
Deafness 16.53 9.93 79 536940 20958 79186411
Sciatica 16.51 9.93 315 536704 32907 79174462
Cells in urine 16.51 9.93 13 537006 211 79207158
Bacterial test positive 16.48 9.93 96 536923 7353 79200016
Hyperammonaemia 16.44 9.93 31 536988 11062 79196307
Device failure 16.38 9.93 11 537008 6250 79201119
Dyspnoea at rest 16.37 9.93 15 537004 7287 79200082
Coagulation factor X level decreased 16.36 9.93 10 537009 105 79207264
Osteolysis 16.28 9.93 5 537014 4493 79202876
Metastases to bone 16.27 9.93 97 536922 24330 79183039
Monocyte percentage increased 16.27 9.93 41 536978 2100 79205269
Hemiparesis 16.19 9.93 147 536872 33586 79173783
Insurance issue 16.17 9.93 79 536940 5654 79201715
Sulphaemoglobinaemia 16.16 9.93 8 537011 53 79207316
Pulmonary alveolar haemorrhage 16.13 9.93 33 536986 11424 79195945
Skin ulcer 16.05 9.93 262 536757 53888 79153481
Rhabdomyolysis 15.99 9.93 551 536468 102580 79104789
Abnormal dreams 15.96 9.93 33 536986 11379 79195990
Application site pain 15.93 9.93 6 537013 4741 79202628
Glutathione decreased 15.92 9.93 8 537011 55 79207314
Nephrogenic systemic fibrosis 15.88 9.93 11 537008 6149 79201220
Hypersensitivity vasculitis 15.88 9.93 14 537005 6929 79200440
Enthesopathy 15.87 9.93 34 536985 11574 79195795
Laboratory test abnormal 15.85 9.93 117 536902 27931 79179438
Reversible airways obstruction 15.84 9.93 41 536978 2135 79205234
Therapy partial responder 15.70 9.93 62 536957 17335 79190034
Staphylococcal infection 15.68 9.93 287 536732 58008 79149361
Metastases to central nervous system 15.66 9.93 57 536962 16318 79191051
Victim of chemical submission 15.66 9.93 19 537000 535 79206834
Administration site bruise 15.54 9.93 12 537007 189 79207180
Pulmonary tuberculosis 15.54 9.93 18 537001 7847 79199522
Adenocarcinoma of colon 15.52 9.93 9 537010 5532 79201837
Complication of device insertion 15.51 9.93 12 537007 6338 79201031
Post cholecystectomy syndrome 15.47 9.93 16 537003 376 79206993
Breast cancer 15.45 9.93 149 536870 33632 79173737
Culture urine positive 15.42 9.93 65 536954 4370 79202999
Ascites 15.39 9.93 389 536630 75173 79132196
Immune effector cell-associated neurotoxicity syndrome 15.38 9.93 79 536940 5769 79201600
Band neutrophil count increased 15.32 9.93 21 536998 669 79206700
Inappropriate antidiuretic hormone secretion 15.24 9.93 109 536910 26204 79181165
Upper gastrointestinal haemorrhage 15.15 9.93 192 536827 41188 79166181
Rash papular 15.15 9.93 86 536933 21830 79185539
Coronary artery stenosis 15.12 9.93 39 536980 12445 79194924
Left ventricular hypertrophy 15.11 9.93 33 536986 11158 79196211
Administration site swelling 15.11 9.93 18 537001 497 79206872
Muscle disorder 14.97 9.93 10 537009 5697 79201672
Drug tolerance 14.94 9.93 22 536997 8653 79198716
Necrotic lymphadenopathy 14.92 9.93 9 537010 92 79207277
Dysphagia 14.92 9.93 671 536348 121465 79085904
Left ventricular failure 14.89 9.93 26 536993 9555 79197814
Vaginal haemorrhage 14.87 9.93 86 536933 21731 79185638
Coronary artery occlusion 14.85 9.93 53 536966 15262 79192107
Febrile bone marrow aplasia 14.77 9.93 42 536977 12978 79194391
Eosinophil percentage increased 14.74 9.93 32 536987 1486 79205883
Infusion site urticaria 14.74 9.93 27 536992 1107 79206262
Squamous cell carcinoma of skin 14.68 9.93 47 536972 13986 79193383
Complication of device removal 14.67 9.93 4 537015 3885 79203484
Pneumonia aspiration 14.67 9.93 341 536678 66626 79140743
Intestinal haemorrhage 14.64 9.93 13 537006 6413 79200956
Skin cancer 14.62 9.93 52 536967 14988 79192381
Hyperglycaemia 14.62 9.93 361 536658 69974 79137395
Serum sickness 14.56 9.93 56 536963 3610 79203759
Squamous cell carcinoma 14.53 9.93 55 536964 15567 79191802
Blood immunoglobulin A decreased 14.53 9.93 31 536988 1422 79205947
Gastrointestinal toxicity 14.52 9.93 20 536999 8089 79199280
Blood immunoglobulin E increased 14.52 9.93 11 537008 5871 79201498
Candida infection 14.48 9.93 176 536843 38038 79169331
Infusion site rash 14.43 9.93 34 536985 1668 79205701
Glucose tolerance impaired 14.41 9.93 20 536999 8064 79199305
Injection site extravasation 14.41 9.93 113 536906 9556 79197813
Post-traumatic stress disorder 14.30 9.93 68 536951 4813 79202556
Polydipsia 14.30 9.93 14 537005 6591 79200778
Oxygen saturation abnormal 14.29 9.93 65 536954 4517 79202852
Suspected COVID-19 14.24 9.93 50 536969 3083 79204286
Hypoacusis 14.21 9.93 132 536887 30018 79177351
Blood creatine phosphokinase increased 14.07 9.93 338 536681 65752 79141617
Syringe issue 14.04 9.93 13 537006 6285 79201084
Haemoglobin urine present 14.04 9.93 24 536995 931 79206438
Vital functions abnormal 13.99 9.93 22 536997 795 79206574
Heavy menstrual bleeding 13.92 9.93 48 536971 13963 79193406
Erysipelas 13.84 9.93 33 536986 10817 79196552
Generalised tonic-clonic seizure 13.84 9.93 210 536809 43700 79163669
Oesophageal stenosis 13.80 9.93 6 537013 4348 79203021
Leukoencephalopathy 13.76 9.93 20 536999 7909 79199460
Atypical femur fracture 13.74 9.93 9 537010 5180 79202189
Pollakiuria 13.72 9.93 173 536846 37144 79170225
Shock haemorrhagic 13.71 9.93 79 536940 19981 79187388
Acute myeloid leukaemia recurrent 13.70 9.93 3 537016 3380 79203989
Mean cell haemoglobin concentration increased 13.68 9.93 23 536996 880 79206489
Anti-erythrocyte antibody positive 13.67 9.93 8 537011 77 79207292
Cystitis 13.65 9.93 458 536561 52274 79155095
Aminoaciduria 13.64 9.93 15 537004 379 79206990
Antipsychotic drug level increased 13.63 9.93 12 537007 5945 79201424
Injection site discomfort 13.62 9.93 9 537010 5157 79202212
C-reactive protein 13.61 9.93 68 536951 4911 79202458
Vein collapse 13.59 9.93 26 536993 1102 79206267
Blood glucose abnormal 13.58 9.93 32 536987 10534 79196835
Respiratory disorder 13.57 9.93 397 536622 44459 79162910
Precancerous cells present 13.54 9.93 27 536992 1180 79206189
Hernia 13.54 9.93 175 536844 16884 79190485
Tooth injury 13.53 9.93 37 536982 1991 79205378
Live birth 13.52 9.93 189 536830 18555 79188814
Total lung capacity increased 13.46 9.93 40 536979 2258 79205111
Bone lesion 13.46 9.93 12 537007 5907 79201462
Pharyngeal oedema 13.44 9.93 60 536959 16212 79191157
Monocyte count increased 13.44 9.93 120 536899 10541 79196828
Catheter site bruise 13.43 9.93 16 537003 442 79206927
Mycobacterial infection 13.42 9.93 4 537015 3664 79203705
Partial seizures 13.38 9.93 25 536994 8953 79198416
Pneumatosis intestinalis 13.34 9.93 14 537005 6383 79200986
Embedded device 13.33 9.93 3 537016 3316 79204053
Galactorrhoea 13.30 9.93 4 537015 3642 79203727
Sensitisation 13.28 9.93 3 537016 3308 79204061
Fear 13.26 9.93 90 536929 21896 79185473
Rheumatoid lung 13.22 9.93 6 537013 4239 79203130
Peripheral arterial occlusive disease 13.21 9.93 22 536997 8236 79199133
Mood swings 13.21 9.93 79 536940 19801 79187568
Complications of transplanted kidney 13.20 9.93 14 537005 6352 79201017
Bezoar 13.18 9.93 44 536975 2644 79204725
Ductus arteriosus stenosis foetal 13.17 9.93 8 537011 83 79207286
Impaired quality of life 13.16 9.93 51 536968 14335 79193034
Spinal compression fracture 13.14 9.93 64 536955 16894 79190475
Head injury 13.09 9.93 175 536844 37194 79170175
Diffuse large B-cell lymphoma recurrent 13.02 9.93 6 537013 4201 79203168
Oedema 13.02 9.93 665 536354 118915 79088454
Pre-existing condition improved 12.98 9.93 11 537008 5552 79201817
Aortic valve stenosis 12.94 9.93 10 537009 5284 79202085
Thirst 12.90 9.93 73 536946 18546 79188823
Postoperative delirium 12.88 9.93 14 537005 349 79207020
Granulocytopenia 12.87 9.93 37 536982 11394 79195975
Cystic fibrosis 12.86 9.93 5 537014 3875 79203494
Secondary immunodeficiency 12.83 9.93 3 537016 3231 79204138
Blood phosphorus increased 12.81 9.93 116 536903 10231 79197138
Myocardial ischaemia 12.78 9.93 110 536909 25409 79181960
Thoracic vertebral fracture 12.74 9.93 10 537009 5243 79202126
Dysuria 12.74 9.93 254 536765 50697 79156672
Device deployment issue 12.70 9.93 3 537016 3209 79204160
Temperature regulation disorder 12.67 9.93 75 536944 5778 79201591
Cyanosis neonatal 12.64 9.93 7 537012 60 79207309
Tachyarrhythmia 12.64 9.93 17 537002 6945 79200424
Cytomegalovirus chorioretinitis 12.64 9.93 11 537008 5479 79201890
Anticholinergic syndrome 12.61 9.93 53 536966 3558 79203811
Arteriospasm coronary 12.60 9.93 16 537003 6700 79200669
Self-medication 12.58 9.93 68 536951 5064 79202305
Delusion of grandeur 12.57 9.93 29 536990 1403 79205966
Urobilinogen urine increased 12.55 9.93 19 537000 664 79206705
Dependent personality disorder 12.54 9.93 9 537010 126 79207243
Monoparesis 12.54 9.93 4 537015 3507 79203862
Transfusion-related circulatory overload 12.50 9.93 14 537005 361 79207008
Hypervolaemia 12.50 9.93 207 536812 42483 79164886
Brain abscess 12.48 9.93 9 537010 4927 79202442
Application site pruritus 12.48 9.93 5 537014 3805 79203564
Femur fracture 12.47 9.93 184 536835 38468 79168901
High density lipoprotein decreased 12.42 9.93 8 537011 4647 79202722
Lupus vulgaris 12.39 9.93 50 536969 3296 79204073
Klebsiella infection 12.37 9.93 59 536960 15661 79191708
Congestive hepatopathy 12.36 9.93 62 536957 4485 79202884
Blood uric acid decreased 12.33 9.93 27 536992 1261 79206108
Leukaemia 12.32 9.93 13 537006 5912 79201457
Urinary casts 12.18 9.93 26 536993 1193 79206176
Acidosis hyperchloraemic 12.17 9.93 21 536998 821 79206548
Intermenstrual bleeding 12.14 9.93 13 537006 5871 79201498
Infusion site irritation 12.13 9.93 20 536999 753 79206616
Urethral obstruction 12.09 9.93 12 537007 268 79207101
Injury 12.07 9.93 638 536381 76858 79130511
Allergy test negative 12.06 9.93 13 537006 321 79207048
Parkinsonism 12.05 9.93 64 536955 16520 79190849
Total lung capacity decreased 12.05 9.93 45 536974 2860 79204509
Anger 12.05 9.93 67 536952 17095 79190274
Abdominal pain 12.03 9.93 2878 534141 386691 78820678
Agranulocytosis 12.02 9.93 222 536797 44808 79162561
Accidental death 12.01 9.93 59 536960 4232 79203137
Alpha 1 microglobulin increased 12.00 9.93 7 537012 67 79207302
Haemoglobin decreased 11.95 9.93 1311 535708 220808 78986561
Febrile neutropenia 11.94 9.93 1752 535267 229247 78978122
Nerve block 11.94 9.93 19 537000 694 79206675
Blood bilirubin increased 11.92 9.93 553 536466 65679 79141690
Rash 11.90 9.93 4202 532817 574156 78633213
Post procedural pulmonary embolism 11.84 9.93 12 537007 275 79207094
Aspartate aminotransferase 11.84 9.93 17 537002 566 79206803
Uterine cancer 11.84 9.93 5 537014 3686 79203683
Rhinalgia 11.84 9.93 39 536980 2328 79205041
Angiokeratoma 11.83 9.93 11 537008 226 79207143
Paresis 11.82 9.93 7 537012 4254 79203115
Limb discomfort 11.81 9.93 153 536866 32697 79174672
Rheumatoid nodule 11.74 9.93 69 536950 17369 79190000
Product preparation error 11.73 9.93 13 537006 5780 79201589
Eosinophilic granulomatosis with polyangiitis 11.67 9.93 5 537014 3655 79203714
Nasal necrosis 11.64 9.93 9 537010 142 79207227
Severe invasive streptococcal infection 11.62 9.93 6 537013 44 79207325
Specific gravity urine increased 11.60 9.93 15 537004 451 79206918
Therapy change 11.57 9.93 20 536999 7379 79199990
Decerebrate posture 11.57 9.93 10 537009 186 79207183
Skin mass 11.54 9.93 23 536996 8040 79199329
Eyelid ptosis 11.54 9.93 37 536982 11007 79196362
Device related thrombosis 11.50 9.93 42 536977 2641 79204728
Diabetic neuropathy 11.47 9.93 15 537004 6201 79201168
Hepatic function abnormal 11.47 9.93 390 536629 72717 79134652
Eye haemorrhage 11.42 9.93 31 536988 9726 79197643
Peripheral sensory neuropathy 11.42 9.93 47 536972 12986 79194383
Epilepsy with myoclonic-atonic seizures 11.39 9.93 8 537011 108 79207261
Hypophagia 11.39 9.93 226 536793 45141 79162228
Complication associated with device 11.38 9.93 70 536949 17426 79189943
Urine oxalate increased 11.37 9.93 11 537008 238 79207131
Lung infiltration 11.37 9.93 99 536920 22813 79184556
Ankylosing spondylitis 11.34 9.93 43 536976 12162 79195207
Movement disorder 11.32 9.93 123 536896 27136 79180233
Metastasis 11.31 9.93 18 537001 6862 79200507
Therapy non-responder 11.29 9.93 507 536512 91798 79115571
Granulocyte count increased 11.26 9.93 26 536993 1259 79206110
Pharyngitis streptococcal 11.23 9.93 116 536903 10598 79196771
Ventricular hypokinesia 11.23 9.93 29 536990 9250 79198119
Vaccination site pain 11.22 9.93 10 537009 194 79207175
Fibrin D dimer increased 11.21 9.93 98 536921 8556 79198813
Small fibre neuropathy 11.21 9.93 16 537003 530 79206839
Chronic gastrointestinal bleeding 11.18 9.93 15 537004 468 79206901
Subarachnoid haemorrhage 11.15 9.93 108 536911 24357 79183012
Encephalopathy 11.13 9.93 558 536461 66839 79140530
Leukocyturia 11.13 9.93 34 536985 1949 79205420
Orbital compartment syndrome 11.10 9.93 7 537012 78 79207291
Eye infection 11.08 9.93 126 536893 11794 79195575
Cold sweat 11.05 9.93 77 536942 18622 79188747
Brain scan abnormal 11.00 9.93 25 536994 1198 79206171
Cachexia 10.99 9.93 38 536981 11045 79196324
Band neutrophil percentage increased 10.98 9.93 14 537005 415 79206954
Haemorrhage intracranial 10.96 9.93 118 536901 26075 79181294
Malaise 10.91 9.93 3035 533984 486834 78720535
Impulsive behaviour 10.91 9.93 3 537016 2897 79204472
Hepatitis B 10.90 9.93 25 536994 8307 79199062
Product dispensing error 10.90 9.93 49 536970 13214 79194155
Focal dyscognitive seizures 10.88 9.93 5 537014 3507 79203862
Diffuse axonal injury 10.86 9.93 8 537011 117 79207252
Injection site irritation 10.84 9.93 6 537013 3784 79203585
Base excess 10.80 9.93 7 537012 82 79207287
Arteriosclerosis 10.80 9.93 75 536944 18152 79189217
Injection site nodule 10.79 9.93 6 537013 3774 79203595
Hydroxyprolinuria 10.78 9.93 6 537013 52 79207317
Mean cell haemoglobin concentration decreased 10.78 9.93 60 536959 4519 79202850
Immunoglobulin G4 related disease 10.76 9.93 11 537008 255 79207114
Peritonitis bacterial 10.75 9.93 31 536988 9536 79197833
Abdominal pain lower 10.71 9.93 150 536869 31632 79175737
Tooth extraction 10.70 9.93 38 536981 10957 79196412
Exposure via inhalation 10.69 9.93 8 537011 120 79207249
Ejection fraction decreased 10.68 9.93 166 536853 34411 79172958
Personality change 10.68 9.93 34 536985 10136 79197233
Fanconi syndrome 10.66 9.93 3 537016 2853 79204516
Embolic stroke 10.63 9.93 23 536996 7803 79199566
Apathy 10.63 9.93 48 536971 12929 79194440
Drug specific antibody present 10.62 9.93 79 536940 6573 79200796
Mucormycosis 10.61 9.93 26 536993 8443 79198926
Dissociation 10.61 9.93 7 537012 4014 79203355
Tumour marker increased 10.53 9.93 8 537011 4264 79203105
Autonomic dysreflexia 10.50 9.93 14 537005 434 79206935
Pneumonia viral 10.50 9.93 101 536918 9057 79198312
B-cell lymphoma 10.47 9.93 16 537003 6199 79201170
Respiratory tract congestion 10.45 9.93 85 536934 19869 79187500
Cardiac operation 10.42 9.93 11 537008 5001 79202368
Testicular infarction 10.41 9.93 6 537013 56 79207313
pH urine increased 10.41 9.93 14 537005 438 79206931
Transferrin decreased 10.39 9.93 13 537006 378 79206991
Haematemesis 10.39 9.93 270 536749 51994 79155375
Flatulence 10.38 9.93 214 536805 42510 79164859
Plasma cell myeloma recurrent 10.37 9.93 11 537008 4990 79202379
Pericardial haemorrhage 10.35 9.93 9 537010 4486 79202883
Amino acid level increased 10.31 9.93 18 537001 710 79206659
Vitamin K deficiency 10.31 9.93 18 537001 710 79206659
Osteogenesis imperfecta 10.30 9.93 15 537004 506 79206863
Mood altered 10.30 9.93 74 536945 17773 79189596
Trichoglossia 10.27 9.93 17 537002 642 79206727
Rheumatoid factor 10.26 9.93 13 537006 383 79206986
Body height decreased 10.24 9.93 27 536992 8553 79198816
Lower gastrointestinal haemorrhage 10.23 9.93 65 536954 16060 79191309
Diaphragmatic rupture 10.16 9.93 10 537009 221 79207148
Inhibitory drug interaction 10.16 9.93 9 537010 4444 79202925
Neonatal respiratory acidosis 10.15 9.93 6 537013 59 79207310
Pregnancy with contraceptive device 10.14 9.93 6 537013 3648 79203721
Coagulation factor VII level decreased 10.13 9.93 10 537009 222 79207147
Product physical issue 10.11 9.93 8 537011 4177 79203192
Diastolic dysfunction 10.10 9.93 38 536981 10773 79196596
Teething 10.06 9.93 7 537012 93 79207276
Cytomegalovirus colitis 10.06 9.93 10 537009 4675 79202694
PCO2 decreased 10.03 9.93 45 536974 3109 79204260
Oral discomfort 9.99 9.93 33 536986 9727 79197642
Granuloma 9.99 9.93 26 536993 8271 79199098
Cardiac arrest 9.96 9.93 1314 535705 170782 79036587
Meniscus injury 9.95 9.93 19 537000 6749 79200620
Diabetic metabolic decompensation 9.93 9.93 5 537014 3327 79204042

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AA09 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
ATC R06AA59 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
FDA MoA N0000000207 Histamine Receptor Antagonists
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018373 Peripheral Nervous System Agents
FDA EPC N0000175750 Antihistamine
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48873 acetylcholine receptor antagonist
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:51177 anti-tussive

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Urticaria indication 126485001
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Morning sickness off-label use 51885006
Ocular hypertension contraindication 4210003 DOID:9282
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hepatic failure contraindication 59927004
Arterial thrombosis contraindication 65198009
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Antihistaminic therapy Indication
Dogs Antihistaminic therapy Indication
Horses Antihistaminic therapy Indication

🐶 Veterinary products

ProductApplicantIngredients
A-H-Tablets 100 mg, A-H-Tablets 25 mg Intervet Inc. 1
A-H Injection Intervet Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.83 Basic
pKa2 4.29 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9089489 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9375404 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9526703 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9937132 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019738 VUID
N0000147830 NUI
D02327 KEGG_DRUG
562-10-7 SECONDARY_CAS_RN
4019049 VANDF
4019738 VANDF
C0013092 UMLSCUI
CHEBI:51380 CHEBI
CHEMBL1004 ChEMBL_ID
DB00366 DRUGBANK_ID
CHEMBL1200392 ChEMBL_ID
D004319 MESH_DESCRIPTOR_UI
C035385 MESH_SUPPLEMENTAL_RECORD_UI
3162 PUBCHEM_CID
7171 IUPHAR_LIGAND_ID
1782 INN_ID
95QB77JKPL UNII
23665 RXNORM
10000 MMSL
4644 MMSL
d03154 MMSL
003372 NDDF
004789 NDDF
412380009 SNOMEDCT_US
44068004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8718 SOLUTION 12.50 mg ORAL OTC monograph final 17 sections
Robitussin Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8718 SOLUTION 12.50 mg ORAL OTC monograph final 17 sections
Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime HUMAN OTC DRUG LABEL 3 0031-8744 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC MONOGRAPH FINAL 17 sections
Robitussin Honey Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8758 SOLUTION 12.50 mg ORAL OTC monograph final 17 sections
Robitussin Honey Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8758 SOLUTION 12.50 mg ORAL OTC monograph final 17 sections
Childrens Robitussin Honey Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8762 SOLUTION 6.25 mg ORAL OTC monograph final 17 sections
Childrens Robitussin Honey Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8762 SOLUTION 6.25 mg ORAL OTC monograph final 17 sections
Good Sense Severe NightTime HUMAN OTC DRUG LABEL 4 0113-0019 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Good Sense Severe NightTime HUMAN OTC DRUG LABEL 4 0113-0019 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
good sense night time HUMAN OTC DRUG LABEL 3 0113-0056 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC monograph final 15 sections
good sense night time HUMAN OTC DRUG LABEL 3 0113-0335 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
good sense night time HUMAN OTC DRUG LABEL 3 0113-0335 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
good sense night time HUMAN OTC DRUG LABEL 3 0113-0335 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Good sense sleep aid HUMAN OTC DRUG LABEL 1 0113-0441 TABLET 25 mg ORAL ANDA 16 sections
good sense nighttime HUMAN OTC DRUG LABEL 3 0113-0459 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
good sense nighttime HUMAN OTC DRUG LABEL 3 0113-0459 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
good sense nighttime HUMAN OTC DRUG LABEL 3 0113-0459 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Good Sense Nighttime Cough HUMAN OTC DRUG LABEL 2 0113-0668 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Good Sense Nighttime Cough HUMAN OTC DRUG LABEL 2 0113-0668 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Good Sense Severe NightTime Cold and Flu HUMAN OTC DRUG LABEL 4 0113-0763 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Good Sense Severe NightTime Cold and Flu HUMAN OTC DRUG LABEL 4 0113-0763 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
good sense night time cold and flu HUMAN OTC DRUG LABEL 4 0113-2501 SOLUTION 6.25 mg ORAL OTC monograph final 16 sections
good sense sleep aid ultra HUMAN OTC DRUG LABEL 1 0113-6044 TABLET 25 mg ORAL ANDA 16 sections
Basic Care Nighttime Cold and Flu HUMAN OTC DRUG LABEL 3 0113-7056 CAPSULE, LIQUID FILLED 6.25 mg ORAL OTC monograph final 16 sections
basic care nighttime cold and flu HUMAN OTC DRUG LABEL 3 0113-7335 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
basic care sleep aid HUMAN OTC DRUG LABEL 1 0113-7441 TABLET 25 mg ORAL ANDA 16 sections
Basic Care Nighttime HUMAN OTC DRUG LABEL 3 0113-7459 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
basic care nighttime cold and flu HUMAN OTC DRUG LABEL 4 0113-7501 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
basic care nighttime cold and flu severe HUMAN OTC DRUG LABEL 4 0113-7763 SOLUTION 12.50 mg ORAL OTC monograph final 16 sections
Alka-Seltzer Plus Severe Cold Powerfast Fizz Night HUMAN OTC DRUG LABEL 4 0280-0021 TABLET, EFFERVESCENT 6.25 mg ORAL OTC monograph final 16 sections