Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, protein-synthesis inhibitors, tetracycline derivatives | 961 | 564-25-0 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 41 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.43 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.69 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.46 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 14 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 5, 1967 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Abortion incomplete | 2014.19 | 10.29 | 522 | 82535 | 2609 | 63403356 |
Drug hypersensitivity | 1159.36 | 10.29 | 1707 | 81350 | 308980 | 63096985 |
Haemorrhage | 912.89 | 10.29 | 705 | 82352 | 60317 | 63345648 |
Jarisch-Herxheimer reaction | 277.40 | 10.29 | 70 | 82987 | 307 | 63405658 |
Pregnancy | 201.82 | 10.29 | 245 | 82812 | 36591 | 63369374 |
Cholangitis sclerosing | 193.69 | 10.29 | 75 | 82982 | 1566 | 63404399 |
Oesophageal ulcer | 158.83 | 10.29 | 89 | 82968 | 4401 | 63401564 |
Endometritis | 136.26 | 10.29 | 51 | 83006 | 967 | 63404998 |
Heavy menstrual bleeding | 131.10 | 10.29 | 138 | 82919 | 17635 | 63388330 |
Gastrointestinal mucosal necrosis | 122.54 | 10.29 | 24 | 83033 | 17 | 63405948 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 98.58 | 10.29 | 56 | 83001 | 2843 | 63403122 |
Deep vein thrombosis postoperative | 96.07 | 10.29 | 95 | 82962 | 11274 | 63394691 |
Vomiting | 93.11 | 10.29 | 1129 | 81928 | 558488 | 62847477 |
Death | 92.54 | 10.29 | 222 | 82835 | 374159 | 63031806 |
Pelvic inflammatory disease | 90.52 | 10.29 | 44 | 83013 | 1618 | 63404347 |
Completed suicide | 88.26 | 10.29 | 40 | 83017 | 145633 | 63260332 |
Injury | 85.71 | 10.29 | 250 | 82807 | 72997 | 63332968 |
Autoimmune disorder | 84.06 | 10.29 | 108 | 82949 | 17069 | 63388896 |
Toxicity to various agents | 76.10 | 10.29 | 129 | 82928 | 247121 | 63158844 |
Fall | 71.48 | 10.29 | 268 | 82789 | 392066 | 63013899 |
Drug ineffective for unapproved indication | 70.70 | 10.29 | 145 | 82912 | 33918 | 63372047 |
Idiopathic intracranial hypertension | 69.66 | 10.29 | 45 | 83012 | 2886 | 63403079 |
Pancreatitis acute | 66.54 | 10.29 | 124 | 82933 | 27042 | 63378923 |
Swollen joint count increased | 65.07 | 10.29 | 145 | 82912 | 35909 | 63370056 |
Uterine perforation | 62.23 | 10.29 | 60 | 82997 | 6903 | 63399062 |
Photoonycholysis | 62.05 | 10.29 | 11 | 83046 | 0 | 63405965 |
Sciatica | 57.46 | 10.29 | 134 | 82923 | 34190 | 63371775 |
Wheezing | 56.94 | 10.29 | 262 | 82795 | 95333 | 63310632 |
Gastrointestinal injury | 56.54 | 10.29 | 23 | 83034 | 549 | 63405416 |
Photosensitivity reaction | 54.93 | 10.29 | 82 | 82975 | 14912 | 63391053 |
Intestinal sepsis | 54.38 | 10.29 | 19 | 83038 | 293 | 63405672 |
Glomerulonephritis minimal lesion | 54.12 | 10.29 | 18 | 83039 | 237 | 63405728 |
Rash | 52.93 | 10.29 | 1028 | 82029 | 559843 | 62846122 |
Nausea | 51.18 | 10.29 | 1470 | 81587 | 853001 | 62552964 |
Rheumatic fever | 50.27 | 10.29 | 147 | 82910 | 42964 | 63363001 |
Coma | 48.85 | 10.29 | 12 | 83045 | 64352 | 63341613 |
Intracranial pressure increased | 48.53 | 10.29 | 46 | 83011 | 5181 | 63400784 |
Oesophagitis | 47.88 | 10.29 | 77 | 82980 | 14931 | 63391034 |
Bone erosion | 47.36 | 10.29 | 84 | 82973 | 17633 | 63388332 |
Pelvic pain | 46.79 | 10.29 | 72 | 82985 | 13447 | 63392518 |
C-reactive protein | 45.40 | 10.29 | 43 | 83014 | 4839 | 63401126 |
Papilloedema | 42.91 | 10.29 | 38 | 83019 | 3922 | 63402043 |
Prescribed overdose | 42.29 | 10.29 | 119 | 82938 | 34034 | 63371931 |
Lip swelling | 41.21 | 10.29 | 111 | 82946 | 30952 | 63375013 |
Febrile neutropenia | 41.01 | 10.29 | 57 | 83000 | 118392 | 63287573 |
Hidradenitis | 40.57 | 10.29 | 32 | 83025 | 2814 | 63403151 |
Product use in unapproved indication | 40.16 | 10.29 | 384 | 82673 | 178696 | 63227269 |
Hyperkalaemia | 39.43 | 10.29 | 11 | 83046 | 54192 | 63351773 |
Drug abuse | 39.31 | 10.29 | 23 | 83034 | 72495 | 63333470 |
Lyme disease | 37.18 | 10.29 | 33 | 83024 | 3416 | 63402549 |
Hypereosinophilic syndrome | 36.62 | 10.29 | 14 | 83043 | 282 | 63405683 |
Muscle spasms | 35.59 | 10.29 | 336 | 82721 | 155814 | 63250151 |
Urticaria | 34.96 | 10.29 | 351 | 82706 | 165451 | 63240514 |
Retained products of conception | 34.87 | 10.29 | 11 | 83046 | 121 | 63405844 |
Sinusitis | 34.80 | 10.29 | 451 | 82606 | 226202 | 63179763 |
Anxiety | 34.72 | 10.29 | 436 | 82621 | 217105 | 63188860 |
Depressed level of consciousness | 34.64 | 10.29 | 19 | 83038 | 62059 | 63343906 |
Swollen tongue | 34.38 | 10.29 | 112 | 82945 | 34688 | 63371277 |
Apparent death | 34.06 | 10.29 | 21 | 83036 | 1241 | 63404724 |
Retinitis | 33.57 | 10.29 | 41 | 83016 | 6155 | 63399810 |
Liver injury | 33.20 | 10.29 | 162 | 82895 | 60358 | 63345607 |
Road traffic accident | 32.74 | 10.29 | 114 | 82943 | 36518 | 63369447 |
Blood pressure increased | 32.60 | 10.29 | 106 | 82951 | 161956 | 63244009 |
Blister | 31.94 | 10.29 | 284 | 82773 | 129530 | 63276435 |
Lower limb fracture | 30.58 | 10.29 | 85 | 82972 | 24136 | 63381829 |
Ectopic pregnancy | 30.58 | 10.29 | 26 | 83031 | 2541 | 63403424 |
C-reactive protein abnormal | 30.19 | 10.29 | 130 | 82927 | 45966 | 63359999 |
Fibromyalgia | 29.97 | 10.29 | 194 | 82863 | 80226 | 63325739 |
Lip dry | 29.93 | 10.29 | 64 | 82993 | 15406 | 63390559 |
Urticaria contact | 29.81 | 10.29 | 7 | 83050 | 21 | 63405944 |
Type 2 diabetes mellitus | 29.52 | 10.29 | 163 | 82894 | 63705 | 63342260 |
Q fever | 29.06 | 10.29 | 10 | 83047 | 147 | 63405818 |
Asthma | 28.82 | 10.29 | 274 | 82783 | 127287 | 63278678 |
Dermatitis acneiform | 28.61 | 10.29 | 34 | 83023 | 4962 | 63401003 |
Dizziness | 28.50 | 10.29 | 750 | 82307 | 429175 | 62976790 |
Conjunctival cyst | 27.63 | 10.29 | 8 | 83049 | 64 | 63405901 |
Toxic epidermal necrolysis | 27.28 | 10.29 | 84 | 82973 | 25250 | 63380715 |
Malignant neoplasm progression | 26.96 | 10.29 | 41 | 83016 | 82080 | 63323885 |
Lupus vulgaris | 26.71 | 10.29 | 36 | 83021 | 5958 | 63400007 |
X-ray abnormal | 26.40 | 10.29 | 42 | 83015 | 8068 | 63397897 |
Visual impairment | 26.32 | 10.29 | 195 | 82862 | 84251 | 63321714 |
Hepatotoxicity | 26.06 | 10.29 | 8 | 83049 | 37033 | 63368932 |
Exostosis | 25.91 | 10.29 | 66 | 82991 | 17796 | 63388169 |
Cerebrovascular accident | 25.87 | 10.29 | 65 | 82992 | 107959 | 63298006 |
Trichomegaly | 25.87 | 10.29 | 8 | 83049 | 82 | 63405883 |
Adjustment disorder with depressed mood | 25.52 | 10.29 | 47 | 83010 | 10157 | 63395808 |
Hypotension | 25.40 | 10.29 | 231 | 82826 | 272373 | 63133592 |
Hypoaesthesia | 25.38 | 10.29 | 334 | 82723 | 168059 | 63237906 |
Periarticular thenar erythema with onycholysis | 25.37 | 10.29 | 7 | 83050 | 46 | 63405919 |
IIIrd nerve injury | 25.27 | 10.29 | 5 | 83052 | 4 | 63405961 |
Blood pressure systolic increased | 24.34 | 10.29 | 16 | 83041 | 47381 | 63358584 |
Keratitis | 24.22 | 10.29 | 26 | 83031 | 3396 | 63402569 |
Hepatitis chronic active | 24.18 | 10.29 | 7 | 83050 | 56 | 63405909 |
Emotional distress | 23.83 | 10.29 | 95 | 82962 | 32454 | 63373511 |
Swelling face | 23.57 | 10.29 | 153 | 82904 | 63322 | 63342643 |
Infection | 23.56 | 10.29 | 426 | 82631 | 228747 | 63177218 |
Aspartate aminotransferase increased | 23.47 | 10.29 | 52 | 83005 | 90225 | 63315740 |
Wound infection | 23.06 | 10.29 | 71 | 82986 | 21339 | 63384626 |
Oesophageal irritation | 23.04 | 10.29 | 8 | 83049 | 121 | 63405844 |
Hepatic cirrhosis | 23 | 10.29 | 78 | 82979 | 24656 | 63381309 |
Osteoarthritis | 22.63 | 10.29 | 207 | 82850 | 95136 | 63310829 |
Drug reaction with eosinophilia and systemic symptoms | 22.60 | 10.29 | 96 | 82961 | 33740 | 63372225 |
Skin odour abnormal | 22.18 | 10.29 | 18 | 83039 | 1648 | 63404317 |
Disinhibition | 22.08 | 10.29 | 14 | 83043 | 869 | 63405096 |
Device capturing issue | 22.07 | 10.29 | 6 | 83051 | 37 | 63405928 |
Macular degeneration | 21.80 | 10.29 | 3 | 83054 | 24373 | 63381592 |
Pneumococcal infection | 21.68 | 10.29 | 11 | 83046 | 444 | 63405521 |
Neutropenia | 21.65 | 10.29 | 137 | 82920 | 174868 | 63231097 |
Cardio-respiratory arrest | 21.61 | 10.29 | 28 | 83029 | 59931 | 63346034 |
Onychomadesis | 21.48 | 10.29 | 32 | 83025 | 5808 | 63400157 |
Breast cancer | 21.44 | 10.29 | 19 | 83038 | 48364 | 63357601 |
Platelet count decreased | 21.29 | 10.29 | 79 | 82978 | 116043 | 63289922 |
Infusion related reaction | 21.19 | 10.29 | 212 | 82845 | 245309 | 63160656 |
Vasculitis | 21.14 | 10.29 | 62 | 82995 | 18147 | 63387818 |
Rash macular | 21.13 | 10.29 | 73 | 82984 | 23291 | 63382674 |
Scar | 21.12 | 10.29 | 52 | 83005 | 13730 | 63392235 |
Abortion spontaneous | 20.85 | 10.29 | 119 | 82938 | 47076 | 63358889 |
Nodular vasculitis | 20.60 | 10.29 | 5 | 83052 | 18 | 63405947 |
Premature delivery | 20.49 | 10.29 | 7 | 83050 | 30274 | 63375691 |
Psoriatic arthropathy | 20.37 | 10.29 | 196 | 82861 | 91324 | 63314641 |
Blood cholesterol increased | 20.25 | 10.29 | 200 | 82857 | 93832 | 63312133 |
Treatment failure | 20.10 | 10.29 | 369 | 82688 | 198674 | 63207291 |
SLE arthritis | 20.10 | 10.29 | 12 | 83045 | 669 | 63405296 |
Sedation | 20.07 | 10.29 | 13 | 83044 | 38796 | 63367169 |
Joint dislocation | 19.93 | 10.29 | 62 | 82995 | 18738 | 63387227 |
VIth nerve paralysis | 19.80 | 10.29 | 13 | 83044 | 857 | 63405108 |
Disease progression | 19.69 | 10.29 | 88 | 82969 | 122670 | 63283295 |
Lipoedema | 19.64 | 10.29 | 9 | 83048 | 289 | 63405676 |
Lupus-like syndrome | 19.63 | 10.29 | 54 | 83003 | 15241 | 63390724 |
Acne pustular | 19.62 | 10.29 | 8 | 83049 | 192 | 63405773 |
Thrombocytopenia | 19.38 | 10.29 | 117 | 82940 | 151040 | 63254925 |
Erosive oesophagitis | 19.38 | 10.29 | 17 | 83040 | 1733 | 63404232 |
Terminal state | 19.15 | 10.29 | 19 | 83038 | 2263 | 63403702 |
Adverse drug reaction | 18.88 | 10.29 | 173 | 82884 | 79541 | 63326424 |
Nephrogenic diabetes insipidus | 18.65 | 10.29 | 13 | 83044 | 946 | 63405019 |
Rhabdomyolysis | 18.60 | 10.29 | 18 | 83039 | 43933 | 63362032 |
Bronchomalacia | 18.48 | 10.29 | 8 | 83049 | 224 | 63405741 |
Injection site reaction | 18.47 | 10.29 | 30 | 83027 | 58494 | 63347471 |
Headache | 18.39 | 10.29 | 1008 | 82049 | 632233 | 62773732 |
Internal injury | 18.36 | 10.29 | 9 | 83048 | 337 | 63405628 |
Alopecia | 18.29 | 10.29 | 321 | 82736 | 337215 | 63068750 |
Small intestine ulcer | 18.10 | 10.29 | 9 | 83048 | 348 | 63405617 |
Rocky mountain spotted fever | 17.98 | 10.29 | 5 | 83052 | 34 | 63405931 |
Cerebral haemorrhage | 17.74 | 10.29 | 9 | 83048 | 30720 | 63375245 |
Rosacea | 17.71 | 10.29 | 26 | 83031 | 4658 | 63401307 |
Infective pulmonary exacerbation of cystic fibrosis | 17.67 | 10.29 | 37 | 83020 | 8780 | 63397185 |
Bradycardia | 17.58 | 10.29 | 44 | 83013 | 73183 | 63332782 |
Foetal exposure during pregnancy | 17.51 | 10.29 | 10 | 83047 | 31952 | 63374013 |
Mouth swelling | 17.47 | 10.29 | 26 | 83031 | 4714 | 63401251 |
Acne conglobata | 17.29 | 10.29 | 4 | 83053 | 11 | 63405954 |
Multiple sclerosis relapse | 17.10 | 10.29 | 23 | 83034 | 48455 | 63357510 |
Overlap syndrome | 17.09 | 10.29 | 12 | 83045 | 884 | 63405081 |
Chest pain | 17.05 | 10.29 | 386 | 82671 | 215573 | 63190392 |
Overdose | 16.99 | 10.29 | 85 | 82972 | 114993 | 63290972 |
Odynophagia | 16.89 | 10.29 | 33 | 83024 | 7453 | 63398512 |
Herpes simplex oesophagitis | 16.80 | 10.29 | 7 | 83050 | 178 | 63405787 |
Electrocardiogram QT prolonged | 16.56 | 10.29 | 33 | 83024 | 59497 | 63346468 |
Ulcerative keratitis | 16.44 | 10.29 | 19 | 83038 | 2691 | 63403274 |
Tendon pain | 16.41 | 10.29 | 21 | 83036 | 3305 | 63402660 |
Myocardial infarction | 16.39 | 10.29 | 71 | 82986 | 99822 | 63306143 |
Burn oesophageal | 16.37 | 10.29 | 7 | 83050 | 190 | 63405775 |
Gait inability | 16.33 | 10.29 | 122 | 82935 | 52837 | 63353128 |
Laryngitis | 16.21 | 10.29 | 54 | 83003 | 16913 | 63389052 |
Rheumatoid factor positive | 16.03 | 10.29 | 175 | 82882 | 84231 | 63321734 |
Medical device discomfort | 16.01 | 10.29 | 16 | 83041 | 1923 | 63404042 |
Blood glucose increased | 16 | 10.29 | 56 | 83001 | 83700 | 63322265 |
Haemoglobin decreased | 15.95 | 10.29 | 118 | 82939 | 145367 | 63260598 |
Blood creatinine increased | 15.94 | 10.29 | 60 | 82997 | 87784 | 63318181 |
Pseudoporphyria | 15.91 | 10.29 | 7 | 83050 | 204 | 63405761 |
Seizure | 15.80 | 10.29 | 105 | 82952 | 132529 | 63273436 |
Cholecystitis chronic | 15.78 | 10.29 | 39 | 83018 | 10322 | 63395643 |
Proteinuria | 15.76 | 10.29 | 58 | 82999 | 19087 | 63386878 |
Secondary amyloidosis | 15.64 | 10.29 | 6 | 83051 | 122 | 63405843 |
Malaria | 15.63 | 10.29 | 7 | 83050 | 213 | 63405752 |
Premature baby | 15.47 | 10.29 | 4 | 83053 | 20731 | 63385234 |
Cardiac failure | 15.47 | 10.29 | 62 | 82995 | 89080 | 63316885 |
Ear infection | 15.36 | 10.29 | 94 | 82963 | 38119 | 63367846 |
Blood pressure fluctuation | 15.32 | 10.29 | 23 | 83034 | 46294 | 63359671 |
Drug ineffective | 15.14 | 10.29 | 1170 | 81887 | 1043595 | 62362370 |
Weight increased | 14.77 | 10.29 | 246 | 82811 | 260546 | 63145419 |
Hemiparesis | 14.71 | 10.29 | 6 | 83051 | 23276 | 63382689 |
Hypocalcaemia | 14.61 | 10.29 | 12 | 83045 | 31701 | 63374264 |
Hypokalaemia | 14.57 | 10.29 | 78 | 82979 | 103726 | 63302239 |
Abdominal pain | 14.54 | 10.29 | 494 | 82563 | 292962 | 63113003 |
Noninfective oophoritis | 14.50 | 10.29 | 5 | 83052 | 74 | 63405891 |
Corneal perforation | 14.49 | 10.29 | 9 | 83048 | 539 | 63405426 |
Malaise | 14.28 | 10.29 | 673 | 82384 | 415281 | 62990684 |
Eosinophilic pneumonia | 14.26 | 10.29 | 16 | 83041 | 2195 | 63403770 |
Arthralgia | 14.24 | 10.29 | 605 | 82452 | 569105 | 62836860 |
Perforation | 14.13 | 10.29 | 12 | 83045 | 1171 | 63404794 |
Pemphigus | 14.09 | 10.29 | 163 | 82894 | 183563 | 63222402 |
Amyloid arthropathy | 14.02 | 10.29 | 9 | 83048 | 571 | 63405394 |
Coronary artery disease | 14.01 | 10.29 | 13 | 83044 | 32364 | 63373601 |
Red blood cell sedimentation rate increased | 13.95 | 10.29 | 102 | 82955 | 43880 | 63362085 |
Cytomegalovirus infection | 13.91 | 10.29 | 5 | 83052 | 20947 | 63385018 |
Leukopenia | 13.89 | 10.29 | 53 | 83004 | 77237 | 63328728 |
Injection site pain | 13.88 | 10.29 | 106 | 82951 | 129694 | 63276271 |
Oesophagitis ulcerative | 13.86 | 10.29 | 9 | 83048 | 582 | 63405383 |
Arthropathy | 13.78 | 10.29 | 220 | 82837 | 234572 | 63171393 |
Glomerulonephritis rapidly progressive | 13.78 | 10.29 | 11 | 83046 | 984 | 63404981 |
Heart rate decreased | 13.78 | 10.29 | 24 | 83033 | 45536 | 63360429 |
Facet joint syndrome | 13.77 | 10.29 | 41 | 83016 | 12097 | 63393868 |
Colitis ulcerative | 13.71 | 10.29 | 69 | 82988 | 26022 | 63379943 |
Cholestatic liver injury | 13.70 | 10.29 | 17 | 83040 | 2593 | 63403372 |
Gastric ulcer perforation | 13.67 | 10.29 | 12 | 83045 | 1224 | 63404741 |
Asymptomatic bacteriuria | 13.65 | 10.29 | 7 | 83050 | 289 | 63405676 |
Medical device site hyperaesthesia | 13.63 | 10.29 | 3 | 83054 | 6 | 63405959 |
Post treatment Lyme disease syndrome | 13.63 | 10.29 | 3 | 83054 | 6 | 63405959 |
Diabetes insipidus | 13.63 | 10.29 | 17 | 83040 | 2608 | 63403357 |
Colorectal cancer metastatic | 13.56 | 10.29 | 9 | 83048 | 604 | 63405361 |
Drug monitoring procedure not performed | 13.50 | 10.29 | 9 | 83048 | 609 | 63405356 |
Neutrophil count decreased | 13.46 | 10.29 | 34 | 83023 | 56372 | 63349593 |
Diabetic ketoacidosis | 13.43 | 10.29 | 5 | 83052 | 20500 | 63385465 |
Blood creatine phosphokinase increased | 13.42 | 10.29 | 12 | 83045 | 30418 | 63375547 |
Metabolic acidosis | 13.40 | 10.29 | 24 | 83033 | 45045 | 63360920 |
Naevoid melanoma | 13.32 | 10.29 | 3 | 83054 | 7 | 63405958 |
Foreign body reaction | 13.30 | 10.29 | 5 | 83052 | 96 | 63405869 |
Cardiac arrest | 13.29 | 10.29 | 69 | 82988 | 92476 | 63313489 |
Herpes zoster | 13.29 | 10.29 | 59 | 82998 | 82403 | 63323562 |
Immunoglobulins decreased | 13.21 | 10.29 | 12 | 83045 | 1280 | 63404685 |
Eosinophilic pneumonia chronic | 13.12 | 10.29 | 6 | 83051 | 192 | 63405773 |
Hallucinations, mixed | 13.04 | 10.29 | 23 | 83034 | 4806 | 63401159 |
Medical device pain | 12.97 | 10.29 | 13 | 83044 | 1567 | 63404398 |
Dermatitis bullous | 12.93 | 10.29 | 32 | 83025 | 8476 | 63397489 |
Illness | 12.93 | 10.29 | 109 | 82948 | 48950 | 63357015 |
Erythema nodosum | 12.88 | 10.29 | 23 | 83034 | 4852 | 63401113 |
Suicide attempt | 12.83 | 10.29 | 39 | 83018 | 60879 | 63345086 |
Injection site haemorrhage | 12.77 | 10.29 | 8 | 83049 | 24306 | 63381659 |
Gastric mucosal lesion | 12.63 | 10.29 | 8 | 83049 | 496 | 63405469 |
Eosinophilic cellulitis | 12.60 | 10.29 | 4 | 83053 | 45 | 63405920 |
Post inflammatory pigmentation change | 12.53 | 10.29 | 7 | 83050 | 344 | 63405621 |
Systemic lupus erythematosus | 12.51 | 10.29 | 195 | 82862 | 208723 | 63197242 |
Metastases to bone | 12.37 | 10.29 | 6 | 83051 | 21013 | 63384952 |
Hypertrichosis | 12.36 | 10.29 | 11 | 83046 | 1143 | 63404822 |
Intrusive thoughts | 12.31 | 10.29 | 6 | 83051 | 222 | 63405743 |
Cognitive disorder | 12.29 | 10.29 | 35 | 83022 | 55780 | 63350185 |
Compartment syndrome | 12.19 | 10.29 | 15 | 83042 | 2269 | 63403696 |
Oesophageal injury | 12.14 | 10.29 | 4 | 83053 | 51 | 63405914 |
Alcohol use disorder | 12.11 | 10.29 | 3 | 83054 | 12 | 63405953 |
Oedema | 12.04 | 10.29 | 187 | 82870 | 97435 | 63308530 |
Lactobacillus infection | 11.94 | 10.29 | 4 | 83053 | 54 | 63405911 |
Duodenal ulcer perforation | 11.91 | 10.29 | 170 | 82887 | 87039 | 63318926 |
Infusion site erythema | 11.91 | 10.29 | 38 | 83019 | 11641 | 63394324 |
Impaired work ability | 11.89 | 10.29 | 4 | 83053 | 17471 | 63388494 |
Device expulsion | 11.89 | 10.29 | 17 | 83040 | 34905 | 63371060 |
Infertility female | 11.87 | 10.29 | 8 | 83049 | 551 | 63405414 |
Accidental exposure to product | 11.86 | 10.29 | 11 | 83046 | 27394 | 63378571 |
Constipation | 11.83 | 10.29 | 215 | 82842 | 224728 | 63181237 |
Blood test abnormal | 11.69 | 10.29 | 3 | 83054 | 15626 | 63390339 |
Suicidal ideation | 11.66 | 10.29 | 129 | 82928 | 62292 | 63343673 |
Oxygen saturation decreased | 11.65 | 10.29 | 68 | 82989 | 88517 | 63317448 |
Bronchial obstruction | 11.65 | 10.29 | 12 | 83045 | 1495 | 63404470 |
Elbow deformity | 11.59 | 10.29 | 12 | 83045 | 1503 | 63404462 |
Indifference | 11.58 | 10.29 | 5 | 83052 | 139 | 63405826 |
Polyserositis | 11.57 | 10.29 | 7 | 83050 | 400 | 63405565 |
Hypercalcaemia | 11.53 | 10.29 | 12 | 83045 | 28310 | 63377655 |
Pulmonary infarction | 11.49 | 10.29 | 16 | 83041 | 2731 | 63403234 |
Alanine aminotransferase increased | 11.45 | 10.29 | 84 | 82973 | 103686 | 63302279 |
Joint effusion | 11.44 | 10.29 | 4 | 83053 | 17056 | 63388909 |
Slow response to stimuli | 11.38 | 10.29 | 10 | 83047 | 1022 | 63404943 |
Spinal cord disorder | 11.37 | 10.29 | 11 | 83046 | 1270 | 63404695 |
Breast cancer stage II | 11.37 | 10.29 | 31 | 83026 | 8705 | 63397260 |
Pulmonary fibrosis | 11.32 | 10.29 | 90 | 82967 | 39719 | 63366246 |
Cutaneous tuberculosis | 11.14 | 10.29 | 5 | 83052 | 153 | 63405812 |
Injection site bruising | 11.01 | 10.29 | 24 | 83033 | 41886 | 63364079 |
Orthostatic hypotension | 10.98 | 10.29 | 19 | 83038 | 36141 | 63369824 |
Tinnitus | 10.94 | 10.29 | 82 | 82975 | 35546 | 63370419 |
Fistula discharge | 10.88 | 10.29 | 10 | 83047 | 1083 | 63404882 |
Genital discomfort | 10.88 | 10.29 | 4 | 83053 | 72 | 63405893 |
Foreign body sensation in eyes | 10.86 | 10.29 | 14 | 83043 | 2220 | 63403745 |
Product prescribing error | 10.86 | 10.29 | 11 | 83046 | 26278 | 63379687 |
Inflammatory bowel disease | 10.83 | 10.29 | 19 | 83038 | 3954 | 63402011 |
Skin lesion | 10.77 | 10.29 | 73 | 82984 | 30648 | 63375317 |
Paronychia | 10.74 | 10.29 | 23 | 83034 | 5542 | 63400423 |
Anal candidiasis | 10.71 | 10.29 | 3 | 83054 | 21 | 63405944 |
Gastrointestinal bacterial overgrowth | 10.64 | 10.29 | 9 | 83048 | 873 | 63405092 |
Pneumonia aspiration | 10.62 | 10.29 | 18 | 83039 | 34522 | 63371443 |
Gastric perforation | 10.57 | 10.29 | 12 | 83045 | 1667 | 63404298 |
Ruptured ectopic pregnancy | 10.56 | 10.29 | 7 | 83050 | 469 | 63405496 |
Accidental overdose | 10.51 | 10.29 | 9 | 83048 | 23300 | 63382665 |
Jaw fracture | 10.51 | 10.29 | 15 | 83042 | 2619 | 63403346 |
Cerebral thrombosis | 10.50 | 10.29 | 12 | 83045 | 1679 | 63404286 |
Post viral fatigue syndrome | 10.45 | 10.29 | 6 | 83051 | 311 | 63405654 |
Papule | 10.39 | 10.29 | 23 | 83034 | 5668 | 63400297 |
Dehydration | 10.31 | 10.29 | 162 | 82895 | 173192 | 63232773 |
Septic pulmonary embolism | 10.31 | 10.29 | 4 | 83053 | 84 | 63405881 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Jarisch-Herxheimer reaction | 755.41 | 11.24 | 166 | 38210 | 425 | 34918130 |
Gastrointestinal mucosal necrosis | 133.99 | 11.24 | 33 | 38343 | 159 | 34918396 |
Rash | 124.01 | 11.24 | 528 | 37848 | 222224 | 34696331 |
Drug hypersensitivity | 115.83 | 11.24 | 266 | 38110 | 80263 | 34838292 |
Congenital hiatus hernia | 115.33 | 11.24 | 41 | 38335 | 803 | 34917752 |
Photosensitivity reaction | 99.78 | 11.24 | 87 | 38289 | 10507 | 34908048 |
Gastrointestinal injury | 97.08 | 11.24 | 31 | 38345 | 430 | 34918125 |
Breath sounds abnormal | 86.84 | 11.24 | 67 | 38309 | 6814 | 34911741 |
Drug ineffective for unapproved indication | 81.97 | 11.24 | 115 | 38261 | 23600 | 34894955 |
Oesophageal ulcer | 78.60 | 11.24 | 48 | 38328 | 3333 | 34915222 |
Cholangitis sclerosing | 78.57 | 11.24 | 36 | 38340 | 1385 | 34917170 |
Soft tissue mass | 73.11 | 11.24 | 31 | 38345 | 988 | 34917567 |
Drug abuse | 72.71 | 11.24 | 11 | 38365 | 99085 | 34819470 |
Neutrophilic dermatosis | 71.39 | 11.24 | 21 | 38355 | 217 | 34918338 |
Multimorbidity | 68.72 | 11.24 | 29 | 38347 | 913 | 34917642 |
Oesophageal perforation | 62.01 | 11.24 | 29 | 38347 | 1170 | 34917385 |
Malignant melanoma in situ | 57.51 | 11.24 | 31 | 38345 | 1697 | 34916858 |
Acquired haemophilia | 54.01 | 11.24 | 25 | 38351 | 985 | 34917570 |
Stevens-Johnson syndrome | 52.34 | 11.24 | 82 | 38294 | 18557 | 34899998 |
Lip swelling | 49.75 | 11.24 | 74 | 38302 | 16006 | 34902549 |
Superinfection | 49.13 | 11.24 | 32 | 38344 | 2487 | 34916068 |
Inflammatory marker increased | 48.77 | 11.24 | 42 | 38334 | 4986 | 34913569 |
Fixed eruption | 47.02 | 11.24 | 27 | 38349 | 1673 | 34916882 |
Malaise | 44.31 | 11.24 | 352 | 38024 | 185473 | 34733082 |
Lung consolidation | 42.79 | 11.24 | 42 | 38334 | 5894 | 34912661 |
Drug ineffective | 42.18 | 11.24 | 719 | 37657 | 456032 | 34462523 |
Bronchiectasis | 40.71 | 11.24 | 52 | 38324 | 9749 | 34908806 |
Swollen tongue | 40.65 | 11.24 | 64 | 38312 | 14541 | 34904014 |
Acne fulminans | 39.65 | 11.24 | 13 | 38363 | 197 | 34918358 |
Dyspnoea | 39.55 | 11.24 | 606 | 37770 | 376176 | 34542379 |
Gastric mucosal lesion | 39.34 | 11.24 | 17 | 38359 | 568 | 34917987 |
Myocardial infarction | 39.29 | 11.24 | 45 | 38331 | 121040 | 34797515 |
Transplant failure | 39.26 | 11.24 | 32 | 38344 | 3521 | 34915034 |
Bacterial pericarditis | 38.48 | 11.24 | 10 | 38366 | 62 | 34918493 |
Wheezing | 38.20 | 11.24 | 116 | 38260 | 41286 | 34877269 |
Hidradenitis | 37.67 | 11.24 | 20 | 38356 | 1062 | 34917493 |
Pulmonary function test abnormal | 36.44 | 11.24 | 27 | 38349 | 2583 | 34915972 |
Factitious disorder | 35.78 | 11.24 | 9 | 38367 | 48 | 34918507 |
Asthma | 34.32 | 11.24 | 114 | 38262 | 42542 | 34876013 |
Dermatitis acneiform | 34.22 | 11.24 | 38 | 38338 | 6151 | 34912404 |
Lower respiratory tract infection | 33.38 | 11.24 | 93 | 38283 | 31544 | 34887011 |
Chronic obstructive pulmonary disease | 32.70 | 11.24 | 123 | 38253 | 48795 | 34869760 |
Febrile neutropenia | 32.58 | 11.24 | 63 | 38313 | 136786 | 34781769 |
Painful respiration | 32.51 | 11.24 | 19 | 38357 | 1217 | 34917338 |
Intracranial pressure increased | 32.34 | 11.24 | 30 | 38346 | 3925 | 34914630 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 31.79 | 11.24 | 19 | 38357 | 1268 | 34917287 |
Drug resistance | 31.17 | 11.24 | 80 | 38296 | 25847 | 34892708 |
Micturition urgency | 30.93 | 11.24 | 37 | 38339 | 6488 | 34912067 |
Chest injury | 30.51 | 11.24 | 20 | 38356 | 1571 | 34916984 |
Sleep disorder due to a general medical condition | 30.51 | 11.24 | 33 | 38343 | 5188 | 34913367 |
Productive cough | 30.36 | 11.24 | 101 | 38275 | 37712 | 34880843 |
Autoimmune hepatitis | 29.86 | 11.24 | 30 | 38346 | 4330 | 34914225 |
Nephrogenic diabetes insipidus | 28.79 | 11.24 | 18 | 38358 | 1303 | 34917252 |
Pruritus | 28.53 | 11.24 | 259 | 38117 | 141722 | 34776833 |
Corneal perforation | 28.21 | 11.24 | 10 | 38366 | 194 | 34918361 |
Q fever | 28.11 | 11.24 | 9 | 38367 | 126 | 34918429 |
Intentional overdose | 27.50 | 11.24 | 7 | 38369 | 43667 | 34874888 |
Oral candidiasis | 26.94 | 11.24 | 48 | 38328 | 12062 | 34906493 |
Bronchial hyperreactivity | 26.87 | 11.24 | 19 | 38357 | 1690 | 34916865 |
Skin plaque | 26.67 | 11.24 | 29 | 38347 | 4585 | 34913970 |
Urethritis mycoplasmal | 26.60 | 11.24 | 6 | 38370 | 18 | 34918537 |
Melanocytic naevus | 25.66 | 11.24 | 21 | 38355 | 2323 | 34916232 |
Hypotension | 25.53 | 11.24 | 141 | 38235 | 221508 | 34697047 |
Skin exfoliation | 25.43 | 11.24 | 77 | 38299 | 27355 | 34891200 |
Infective pulmonary exacerbation of cystic fibrosis | 25.02 | 11.24 | 34 | 38342 | 6767 | 34911788 |
Full blood count abnormal | 24.97 | 11.24 | 60 | 38316 | 18608 | 34899947 |
Walking aid user | 24.85 | 11.24 | 19 | 38357 | 1905 | 34916650 |
Lyme disease | 24.84 | 11.24 | 15 | 38361 | 1020 | 34917535 |
Ulcerative keratitis | 24.39 | 11.24 | 18 | 38358 | 1711 | 34916844 |
Tubulointerstitial nephritis | 24.38 | 11.24 | 64 | 38312 | 20960 | 34897595 |
Drug-induced liver injury | 24.03 | 11.24 | 78 | 38298 | 28754 | 34889801 |
Death | 24.02 | 11.24 | 301 | 38075 | 397748 | 34520807 |
Hypercholesterolaemia | 23.84 | 11.24 | 38 | 38338 | 8724 | 34909831 |
Acute generalised exanthematous pustulosis | 23.61 | 11.24 | 33 | 38343 | 6743 | 34911812 |
Crystal nephropathy | 23.47 | 11.24 | 11 | 38365 | 446 | 34918109 |
Immunosuppressant drug level increased | 23.39 | 11.24 | 31 | 38345 | 6024 | 34912531 |
Tachyarrhythmia | 23.20 | 11.24 | 24 | 38352 | 3584 | 34914971 |
Treatment failure | 23.04 | 11.24 | 107 | 38269 | 46590 | 34871965 |
Bronchitis | 22.84 | 11.24 | 99 | 38277 | 41864 | 34876691 |
Distal intestinal obstruction syndrome | 22.81 | 11.24 | 10 | 38366 | 346 | 34918209 |
Periorbital swelling | 22.81 | 11.24 | 12 | 38364 | 625 | 34917930 |
Cough | 22.54 | 11.24 | 258 | 38118 | 149882 | 34768673 |
C-reactive protein increased | 22.43 | 11.24 | 16 | 38360 | 54082 | 34864473 |
Drug reaction with eosinophilia and systemic symptoms | 22.05 | 11.24 | 83 | 38293 | 32929 | 34885626 |
Benign prostatic hyperplasia | 22.04 | 11.24 | 49 | 38327 | 14446 | 34904109 |
Obstructive airways disorder | 22.03 | 11.24 | 51 | 38325 | 15443 | 34903112 |
Swelling face | 21.55 | 11.24 | 65 | 38311 | 23040 | 34895515 |
Psoriasis | 21.46 | 11.24 | 92 | 38284 | 38720 | 34879835 |
Blood glucose increased | 21.40 | 11.24 | 25 | 38351 | 66693 | 34851862 |
Joint injury | 21.23 | 11.24 | 37 | 38339 | 9136 | 34909419 |
Antinuclear antibody negative | 21.05 | 11.24 | 5 | 38371 | 20 | 34918535 |
Skin depigmentation | 20.87 | 11.24 | 10 | 38366 | 426 | 34918129 |
Radiation fibrosis - lung | 20.86 | 11.24 | 5 | 38371 | 21 | 34918534 |
Overdose | 20.73 | 11.24 | 43 | 38333 | 91016 | 34827539 |
Aortic aneurysm | 20.68 | 11.24 | 31 | 38345 | 6748 | 34911807 |
Angina bullosa haemorrhagica | 20.66 | 11.24 | 6 | 38370 | 59 | 34918496 |
Rales | 20.49 | 11.24 | 38 | 38338 | 9845 | 34908710 |
Dermatitis | 20.38 | 11.24 | 37 | 38339 | 9431 | 34909124 |
Oesophageal stenosis | 20 | 11.24 | 16 | 38360 | 1714 | 34916841 |
General physical health deterioration | 19.92 | 11.24 | 73 | 38303 | 128196 | 34790359 |
Blood creatinine increased | 19.86 | 11.24 | 47 | 38329 | 94929 | 34823626 |
Pancreatitis acute | 19.84 | 11.24 | 72 | 38304 | 28069 | 34890486 |
Jaundice | 19.53 | 11.24 | 78 | 38298 | 31804 | 34886751 |
Flashback | 19.32 | 11.24 | 7 | 38369 | 145 | 34918410 |
Autoimmune blistering disease | 19.22 | 11.24 | 4 | 38372 | 7 | 34918548 |
Cardiomegaly | 18.93 | 11.24 | 48 | 38328 | 15390 | 34903165 |
Papule | 18.85 | 11.24 | 23 | 38353 | 4116 | 34914439 |
Platelet count decreased | 18.67 | 11.24 | 68 | 38308 | 119649 | 34798906 |
Acne | 18.65 | 11.24 | 39 | 38337 | 11027 | 34907528 |
Oesophageal carcinoma | 18.33 | 11.24 | 35 | 38341 | 9269 | 34909286 |
Coma | 18.30 | 11.24 | 14 | 38362 | 45664 | 34872891 |
Rash pruritic | 18.21 | 11.24 | 68 | 38308 | 26873 | 34891682 |
Tinnitus | 18.20 | 11.24 | 56 | 38320 | 20062 | 34898493 |
Gastroduodenal haemorrhage | 18.13 | 11.24 | 7 | 38369 | 174 | 34918381 |
Tooth injury | 18.03 | 11.24 | 13 | 38363 | 1192 | 34917363 |
Penile erythema | 17.95 | 11.24 | 7 | 38369 | 179 | 34918376 |
SAPHO syndrome | 17.93 | 11.24 | 8 | 38368 | 289 | 34918266 |
Erythema migrans | 17.82 | 11.24 | 5 | 38371 | 43 | 34918512 |
Mouth ulceration | 17.81 | 11.24 | 40 | 38336 | 11870 | 34906685 |
Rash erythematous | 17.69 | 11.24 | 64 | 38312 | 24913 | 34893642 |
Dysphagia | 17.55 | 11.24 | 123 | 38253 | 62258 | 34856297 |
Splenic infarction | 17.47 | 11.24 | 16 | 38360 | 2059 | 34916496 |
Laryngeal injury | 17.45 | 11.24 | 3 | 38373 | 0 | 34918555 |
Gastrooesophageal reflux disease | 17.33 | 11.24 | 85 | 38291 | 37839 | 34880716 |
Periostosis | 17.05 | 11.24 | 4 | 38372 | 15 | 34918540 |
Fall | 16.90 | 11.24 | 142 | 38234 | 202743 | 34715812 |
Abscess limb | 16.76 | 11.24 | 20 | 38356 | 3497 | 34915058 |
Haemoglobin decreased | 16.67 | 11.24 | 72 | 38304 | 120700 | 34797855 |
Methaemoglobinaemia | 16.47 | 11.24 | 20 | 38356 | 3561 | 34914994 |
Loss of personal independence in daily activities | 16.34 | 11.24 | 76 | 38300 | 33103 | 34885452 |
Red blood cell sedimentation rate decreased | 16.24 | 11.24 | 5 | 38371 | 61 | 34918494 |
Oropharyngeal pain | 15.83 | 11.24 | 79 | 38297 | 35406 | 34883149 |
Pustule | 15.81 | 11.24 | 9 | 38367 | 548 | 34918007 |
Ocular surface squamous neoplasia | 15.80 | 11.24 | 4 | 38372 | 22 | 34918533 |
Babesiosis | 15.70 | 11.24 | 6 | 38370 | 145 | 34918410 |
Hyperkalaemia | 15.59 | 11.24 | 33 | 38343 | 69356 | 34849199 |
Respiratory tract infection bacterial | 15.51 | 11.24 | 14 | 38362 | 1768 | 34916787 |
Papillary renal cell carcinoma | 15.48 | 11.24 | 7 | 38369 | 261 | 34918294 |
Vitamin K deficiency | 15.43 | 11.24 | 7 | 38369 | 263 | 34918292 |
Arthritis gonococcal | 15.37 | 11.24 | 3 | 38373 | 3 | 34918552 |
Hypoacusis | 15.33 | 11.24 | 46 | 38330 | 16255 | 34902300 |
Gastrointestinal haemorrhage | 15.33 | 11.24 | 48 | 38328 | 88429 | 34830126 |
Post infection glomerulonephritis | 15.18 | 11.24 | 5 | 38371 | 77 | 34918478 |
Gastritis erosive | 15.15 | 11.24 | 25 | 38351 | 5907 | 34912648 |
Ischaemic cardiomyopathy | 15.08 | 11.24 | 26 | 38350 | 6363 | 34912192 |
Retinopathy hypertensive | 15.02 | 11.24 | 7 | 38369 | 280 | 34918275 |
Infective exacerbation of bronchiectasis | 14.92 | 11.24 | 8 | 38368 | 433 | 34918122 |
Cerebral haemorrhage | 14.92 | 11.24 | 10 | 38366 | 34927 | 34883628 |
Hair colour changes | 14.89 | 11.24 | 14 | 38362 | 1863 | 34916692 |
Blister | 14.87 | 11.24 | 57 | 38319 | 22801 | 34895754 |
Breast inflammation | 14.85 | 11.24 | 4 | 38372 | 29 | 34918526 |
Lactic acidosis | 14.79 | 11.24 | 10 | 38366 | 34762 | 34883793 |
Prescription form tampering | 14.51 | 11.24 | 8 | 38368 | 458 | 34918097 |
Mastocytosis | 14.19 | 11.24 | 4 | 38372 | 35 | 34918520 |
Idiopathic intracranial hypertension | 13.90 | 11.24 | 9 | 38367 | 692 | 34917863 |
Clostridium difficile infection | 13.87 | 11.24 | 49 | 38327 | 18849 | 34899706 |
Nodule | 13.86 | 11.24 | 26 | 38350 | 6793 | 34911762 |
Depressed level of consciousness | 13.79 | 11.24 | 16 | 38360 | 42825 | 34875730 |
Blood pressure increased | 13.76 | 11.24 | 50 | 38326 | 88052 | 34830503 |
Rheumatoid arthritis | 13.75 | 11.24 | 13 | 38363 | 38225 | 34880330 |
Odynophagia | 13.74 | 11.24 | 23 | 38353 | 5498 | 34913057 |
Rosacea | 13.72 | 11.24 | 11 | 38365 | 1182 | 34917373 |
Amoebic dysentery | 13.72 | 11.24 | 4 | 38372 | 40 | 34918515 |
PaO2/FiO2 ratio decreased | 13.72 | 11.24 | 4 | 38372 | 40 | 34918515 |
Skin lesion | 13.67 | 11.24 | 54 | 38322 | 21907 | 34896648 |
Protein total abnormal | 13.65 | 11.24 | 7 | 38369 | 346 | 34918209 |
Limb mass | 13.62 | 11.24 | 9 | 38367 | 717 | 34917838 |
Hypersomnia | 13.60 | 11.24 | 37 | 38339 | 12370 | 34906185 |
Symmetrical drug-related intertriginous and flexural exanthema | 13.57 | 11.24 | 7 | 38369 | 350 | 34918205 |
Rhinorrhoea | 13.54 | 11.24 | 60 | 38316 | 25608 | 34892947 |
Respiratory tract infection | 13.52 | 11.24 | 50 | 38326 | 19662 | 34898893 |
Loss of consciousness | 13.52 | 11.24 | 46 | 38330 | 82621 | 34835934 |
Loose body in joint | 13.45 | 11.24 | 4 | 38372 | 43 | 34918512 |
Necrotising panniculitis | 13.45 | 11.24 | 4 | 38372 | 43 | 34918512 |
Overlap syndrome | 13.44 | 11.24 | 5 | 38371 | 112 | 34918443 |
Staphylococcal infection | 13.27 | 11.24 | 71 | 38305 | 32689 | 34885866 |
Suicide attempt | 13.26 | 11.24 | 14 | 38362 | 39102 | 34879453 |
Pathogen resistance | 13.25 | 11.24 | 31 | 38345 | 9451 | 34909104 |
Mouth swelling | 13.13 | 11.24 | 13 | 38363 | 1843 | 34916712 |
Tendon disorder | 13.13 | 11.24 | 16 | 38360 | 2859 | 34915696 |
Weight increased | 13.12 | 11.24 | 55 | 38321 | 92978 | 34825577 |
Malignant neoplasm progression | 13.08 | 11.24 | 51 | 38325 | 87995 | 34830560 |
Rhinocerebral mucormycosis | 13.04 | 11.24 | 8 | 38368 | 560 | 34917995 |
Rebound effect | 13.01 | 11.24 | 17 | 38359 | 3257 | 34915298 |
Red blood cell burr cells present | 12.98 | 11.24 | 4 | 38372 | 49 | 34918506 |
Serotonin syndrome | 12.93 | 11.24 | 3 | 38373 | 19930 | 34898625 |
Genital rash | 12.91 | 11.24 | 8 | 38368 | 570 | 34917985 |
Loss of proprioception | 12.82 | 11.24 | 7 | 38369 | 393 | 34918162 |
Hepatic function abnormal | 12.80 | 11.24 | 18 | 38358 | 44345 | 34874210 |
Immune reconstitution inflammatory syndrome | 12.63 | 11.24 | 29 | 38347 | 8730 | 34909825 |
Cinchonism | 12.63 | 11.24 | 3 | 38373 | 12 | 34918543 |
Product use in unapproved indication | 12.62 | 11.24 | 190 | 38186 | 117309 | 34801246 |
Eyelid margin crusting | 12.58 | 11.24 | 6 | 38370 | 253 | 34918302 |
Prostate cancer | 12.56 | 11.24 | 15 | 38361 | 39634 | 34878921 |
Contraindicated product prescribed | 12.55 | 11.24 | 7 | 38369 | 410 | 34918145 |
Blood pressure fluctuation | 12.54 | 11.24 | 6 | 38370 | 25243 | 34893312 |
White blood cell count decreased | 12.51 | 11.24 | 58 | 38318 | 95387 | 34823168 |
Interleukin-2 receptor increased | 12.46 | 11.24 | 5 | 38371 | 138 | 34918417 |
Tendon discomfort | 12.43 | 11.24 | 6 | 38370 | 260 | 34918295 |
Herpes dermatitis | 12.43 | 11.24 | 4 | 38372 | 57 | 34918498 |
Calciphylaxis | 12.41 | 11.24 | 10 | 38366 | 1082 | 34917473 |
Dermatitis bullous | 12.37 | 11.24 | 25 | 38351 | 6897 | 34911658 |
Portal hypertensive gastropathy | 12.31 | 11.24 | 8 | 38368 | 619 | 34917936 |
Cardiac arrest | 12.27 | 11.24 | 59 | 38317 | 96100 | 34822455 |
Papilloedema | 12.23 | 11.24 | 15 | 38361 | 2698 | 34915857 |
Cardiac failure | 12.22 | 11.24 | 55 | 38321 | 91193 | 34827362 |
Arthritis allergic | 12.09 | 11.24 | 3 | 38373 | 15 | 34918540 |
Psychogenic visual disorder | 12.09 | 11.24 | 3 | 38373 | 15 | 34918540 |
Oesophagitis | 12.08 | 11.24 | 37 | 38339 | 13224 | 34905331 |
Altered state of consciousness | 12.06 | 11.24 | 5 | 38371 | 22888 | 34895667 |
Gastrointestinal disorder | 12.05 | 11.24 | 71 | 38305 | 33877 | 34884678 |
Skin reaction | 11.98 | 11.24 | 21 | 38355 | 5209 | 34913346 |
Cutaneous sarcoidosis | 11.95 | 11.24 | 5 | 38371 | 154 | 34918401 |
Intentional product use issue | 11.93 | 11.24 | 109 | 38267 | 59707 | 34858848 |
Viral pharyngitis | 11.77 | 11.24 | 5 | 38371 | 160 | 34918395 |
Rash maculo-papular | 11.76 | 11.24 | 62 | 38314 | 28389 | 34890166 |
Erythema | 11.74 | 11.24 | 149 | 38227 | 88631 | 34829924 |
Intentional product misuse | 11.73 | 11.24 | 20 | 38356 | 45591 | 34872964 |
Burn oesophageal | 11.67 | 11.24 | 4 | 38372 | 70 | 34918485 |
Hepatic encephalopathy | 11.58 | 11.24 | 39 | 38337 | 14646 | 34903909 |
Skin hyperpigmentation | 11.53 | 11.24 | 16 | 38360 | 3248 | 34915307 |
Photoonycholysis | 11.49 | 11.24 | 3 | 38373 | 19 | 34918536 |
Orbital infection | 11.49 | 11.24 | 3 | 38373 | 19 | 34918536 |
Penile rash | 11.49 | 11.24 | 3 | 38373 | 19 | 34918536 |
Toxicity to various agents | 11.48 | 11.24 | 153 | 38223 | 200209 | 34718346 |
Ischaemic stroke | 11.34 | 11.24 | 3 | 38373 | 18247 | 34900308 |
Folliculitis | 11.33 | 11.24 | 19 | 38357 | 4547 | 34914008 |
Infusion related reaction | 11.29 | 11.24 | 26 | 38350 | 53031 | 34865524 |
Cat scratch disease | 11.25 | 11.24 | 5 | 38371 | 179 | 34918376 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Abortion incomplete | 2016.52 | 10.01 | 520 | 103561 | 2544 | 79637763 |
Drug hypersensitivity | 1032.55 | 10.01 | 1584 | 102497 | 297332 | 79342975 |
Jarisch-Herxheimer reaction | 913.98 | 10.01 | 219 | 103862 | 738 | 79639569 |
Haemorrhage | 691.80 | 10.01 | 717 | 103364 | 90401 | 79549906 |
Cholangitis sclerosing | 274.59 | 10.01 | 110 | 103971 | 2527 | 79637780 |
Pregnancy | 258.93 | 10.01 | 241 | 103840 | 26610 | 79613697 |
Gastrointestinal mucosal necrosis | 242.36 | 10.01 | 57 | 104024 | 173 | 79640134 |
Rash | 174.66 | 10.01 | 1321 | 102760 | 577037 | 79063270 |
Oesophageal ulcer | 160.90 | 10.01 | 105 | 103976 | 6870 | 79633437 |
Gastrointestinal injury | 149.25 | 10.01 | 54 | 104027 | 929 | 79639378 |
Heavy menstrual bleeding | 147.26 | 10.01 | 132 | 103949 | 13879 | 79626428 |
Endometritis | 144.01 | 10.01 | 50 | 104031 | 758 | 79639549 |
Drug abuse | 136.19 | 10.01 | 24 | 104057 | 162667 | 79477640 |
Photosensitivity reaction | 131.71 | 10.01 | 150 | 103931 | 20977 | 79619330 |
Drug ineffective for unapproved indication | 128.61 | 10.01 | 236 | 103845 | 51002 | 79589305 |
Completed suicide | 116.65 | 10.01 | 90 | 103991 | 245677 | 79394630 |
Congenital hiatus hernia | 105.73 | 10.01 | 40 | 104041 | 784 | 79639523 |
Swollen joint count increased | 104.46 | 10.01 | 139 | 103942 | 22788 | 79617519 |
Deep vein thrombosis postoperative | 98.84 | 10.01 | 94 | 103987 | 10658 | 79629649 |
Death | 98.59 | 10.01 | 393 | 103688 | 566121 | 79074186 |
Fall | 96.22 | 10.01 | 321 | 103760 | 487308 | 79152999 |
Toxicity to various agents | 92.72 | 10.01 | 264 | 103817 | 421276 | 79219031 |
Pelvic inflammatory disease | 85.50 | 10.01 | 40 | 104041 | 1352 | 79638955 |
Rheumatic fever | 84.04 | 10.01 | 141 | 103940 | 28384 | 79611923 |
Lip swelling | 83.84 | 10.01 | 173 | 103908 | 40738 | 79599569 |
Pancreatitis acute | 82.63 | 10.01 | 193 | 103888 | 49411 | 79590896 |
Vomiting | 82.41 | 10.01 | 1272 | 102809 | 664556 | 78975751 |
Autoimmune disorder | 82.35 | 10.01 | 105 | 103976 | 16507 | 79623800 |
Febrile neutropenia | 81.78 | 10.01 | 109 | 103972 | 230890 | 79409417 |
Wheezing | 80.00 | 10.01 | 333 | 103748 | 116331 | 79523976 |
Injury | 77.48 | 10.01 | 250 | 103831 | 77246 | 79563061 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 73.69 | 10.01 | 51 | 104030 | 3678 | 79636629 |
Idiopathic intracranial hypertension | 73.09 | 10.01 | 48 | 104033 | 3174 | 79637133 |
Swollen tongue | 70.21 | 10.01 | 165 | 103916 | 42405 | 79597902 |
Intracranial pressure increased | 67.61 | 10.01 | 68 | 104013 | 8254 | 79632053 |
Photoonycholysis | 67.02 | 10.01 | 14 | 104067 | 19 | 79640288 |
Coma | 66.62 | 10.01 | 24 | 104057 | 100625 | 79539682 |
Uterine perforation | 65.48 | 10.01 | 59 | 104022 | 6244 | 79634063 |
Soft tissue mass | 63.97 | 10.01 | 32 | 104049 | 1256 | 79639051 |
Blister | 63.96 | 10.01 | 317 | 103764 | 119159 | 79521148 |
Sciatica | 60.59 | 10.01 | 134 | 103947 | 33088 | 79607219 |
Hypotension | 57.03 | 10.01 | 339 | 103742 | 439978 | 79200329 |
Pelvic pain | 54.72 | 10.01 | 77 | 104004 | 13304 | 79627003 |
Depressed level of consciousness | 54.56 | 10.01 | 29 | 104052 | 96623 | 79543684 |
Hyperkalaemia | 52.84 | 10.01 | 43 | 104038 | 114355 | 79525952 |
Oesophageal perforation | 52.55 | 10.01 | 30 | 104051 | 1541 | 79638766 |
Gastric mucosal lesion | 51.26 | 10.01 | 25 | 104056 | 928 | 79639379 |
Blood pressure increased | 51.24 | 10.01 | 126 | 103955 | 211234 | 79429073 |
Myocardial infarction | 51.00 | 10.01 | 102 | 103979 | 184027 | 79456280 |
Papilloedema | 50.76 | 10.01 | 51 | 104030 | 6182 | 79634125 |
Multimorbidity | 49.54 | 10.01 | 28 | 104053 | 1411 | 79638896 |
Neutrophilic dermatosis | 49.19 | 10.01 | 21 | 104060 | 569 | 79639738 |
Q fever | 49.07 | 10.01 | 17 | 104064 | 256 | 79640051 |
Urticaria | 48.49 | 10.01 | 410 | 103671 | 184791 | 79455516 |
Platelet count decreased | 48.01 | 10.01 | 115 | 103966 | 194549 | 79445758 |
Asthma | 47.14 | 10.01 | 320 | 103761 | 134775 | 79505532 |
Nephrogenic diabetes insipidus | 46.49 | 10.01 | 31 | 104050 | 2103 | 79638204 |
Type 2 diabetes mellitus | 45.55 | 10.01 | 171 | 103910 | 56951 | 79583356 |
C-reactive protein | 44.76 | 10.01 | 43 | 104038 | 4936 | 79635371 |
Dermatitis acneiform | 44.62 | 10.01 | 60 | 104021 | 9933 | 79630374 |
Lupus vulgaris | 44.31 | 10.01 | 36 | 104045 | 3310 | 79636997 |
Lyme disease | 44.27 | 10.01 | 36 | 104045 | 3314 | 79636993 |
Liver injury | 43.92 | 10.01 | 168 | 103913 | 56446 | 79583861 |
Fixed eruption | 43.87 | 10.01 | 34 | 104047 | 2920 | 79637387 |
Nausea | 43.78 | 10.01 | 1592 | 102489 | 955604 | 78684703 |
Bone erosion | 43.26 | 10.01 | 81 | 104000 | 17766 | 79622541 |
Oesophagitis | 42.09 | 10.01 | 96 | 103985 | 24193 | 79616114 |
Stevens-Johnson syndrome | 41.56 | 10.01 | 129 | 103952 | 39037 | 79601270 |
Overdose | 41.43 | 10.01 | 114 | 103967 | 184092 | 79456215 |
Treatment failure | 41.28 | 10.01 | 371 | 103710 | 170115 | 79470192 |
Ulcerative keratitis | 41.25 | 10.01 | 36 | 104045 | 3653 | 79636654 |
Swelling face | 41.02 | 10.01 | 193 | 103888 | 71019 | 79569288 |
Malaise | 40.76 | 10.01 | 880 | 103201 | 488989 | 79151318 |
Malignant neoplasm progression | 40.58 | 10.01 | 72 | 104009 | 135918 | 79504389 |
Fibromyalgia | 39.74 | 10.01 | 178 | 103903 | 64162 | 79576145 |
Ectopic pregnancy | 39.62 | 10.01 | 26 | 104055 | 1717 | 79638590 |
Drug reaction with eosinophilia and systemic symptoms | 39.13 | 10.01 | 177 | 103904 | 64067 | 79576240 |
Cardio-respiratory arrest | 38.58 | 10.01 | 51 | 104030 | 108459 | 79531848 |
Malignant melanoma in situ | 38.12 | 10.01 | 29 | 104052 | 2423 | 79637884 |
Prescribed overdose | 37.66 | 10.01 | 122 | 103959 | 37761 | 79602546 |
Psoriatic arthropathy | 36.91 | 10.01 | 200 | 103881 | 77799 | 79562508 |
Acne fulminans | 36.80 | 10.01 | 13 | 104068 | 208 | 79640099 |
Haemoglobin decreased | 36.70 | 10.01 | 157 | 103924 | 221962 | 79418345 |
Bacterial pericarditis | 36.10 | 10.01 | 10 | 104071 | 67 | 79640240 |
X-ray abnormal | 35.77 | 10.01 | 41 | 104040 | 5772 | 79634535 |
Retained products of conception | 35.40 | 10.01 | 11 | 104070 | 115 | 79640192 |
Acquired haemophilia | 35.12 | 10.01 | 25 | 104056 | 1886 | 79638421 |
Intestinal sepsis | 35.08 | 10.01 | 19 | 104062 | 880 | 79639427 |
Retinitis | 35.06 | 10.01 | 40 | 104041 | 5603 | 79634704 |
Blood creatinine increased | 34.84 | 10.01 | 96 | 103985 | 154961 | 79485346 |
Glomerulonephritis minimal lesion | 34.57 | 10.01 | 18 | 104063 | 769 | 79639538 |
Rheumatoid factor positive | 34.33 | 10.01 | 162 | 103919 | 59677 | 79580630 |
Cerebrovascular accident | 34.26 | 10.01 | 97 | 103984 | 155195 | 79485112 |
Cerebral haemorrhage | 33.00 | 10.01 | 17 | 104064 | 57656 | 79582651 |
Inflammatory marker increased | 32.85 | 10.01 | 54 | 104027 | 10686 | 79629621 |
Corneal perforation | 32.23 | 10.01 | 17 | 104064 | 746 | 79639561 |
Blood glucose increased | 31.56 | 10.01 | 64 | 104017 | 114911 | 79525396 |
Cardiac arrest | 31.36 | 10.01 | 117 | 103964 | 171979 | 79468328 |
Breath sounds abnormal | 30.89 | 10.01 | 66 | 104015 | 15918 | 79624389 |
Infective pulmonary exacerbation of cystic fibrosis | 30.74 | 10.01 | 58 | 104023 | 12793 | 79627514 |
Onychomadesis | 30.62 | 10.01 | 36 | 104045 | 5206 | 79635101 |
Blood pressure fluctuation | 30.06 | 10.01 | 26 | 104055 | 67119 | 79573188 |
Osteoarthritis | 29.96 | 10.01 | 206 | 103875 | 87103 | 79553204 |
Lower limb fracture | 29.95 | 10.01 | 82 | 103999 | 23133 | 79617174 |
Blood pressure systolic increased | 29.92 | 10.01 | 26 | 104055 | 66960 | 79573347 |
Urticaria contact | 29.82 | 10.01 | 7 | 104074 | 21 | 79640286 |
Rash macular | 29.57 | 10.01 | 94 | 103987 | 28805 | 79611502 |
Intentional overdose | 29.07 | 10.01 | 59 | 104022 | 105901 | 79534406 |
Lip dry | 29.03 | 10.01 | 63 | 104018 | 15355 | 79624952 |
Micturition urgency | 28.94 | 10.01 | 56 | 104025 | 12585 | 79627722 |
Burn oesophageal | 28.91 | 10.01 | 11 | 104070 | 219 | 79640088 |
Duodenal ulcer perforation | 28.81 | 10.01 | 166 | 103915 | 66045 | 79574262 |
Hidradenitis | 28.72 | 10.01 | 27 | 104054 | 3017 | 79637290 |
Rhabdomyolysis | 28.65 | 10.01 | 57 | 104024 | 103074 | 79537233 |
Exostosis | 28.51 | 10.01 | 66 | 104015 | 16792 | 79623515 |
Hypereosinophilic syndrome | 28.36 | 10.01 | 14 | 104067 | 534 | 79639773 |
Bradycardia | 28.21 | 10.01 | 87 | 103994 | 135470 | 79504837 |
Odynophagia | 28.19 | 10.01 | 52 | 104029 | 11275 | 79629032 |
Mouth swelling | 28.04 | 10.01 | 37 | 104044 | 6014 | 79634293 |
Cardiac failure | 27.74 | 10.01 | 106 | 103975 | 154736 | 79485571 |
Lupus-like syndrome | 27.68 | 10.01 | 58 | 104023 | 13799 | 79626508 |
Anxiety | 27.67 | 10.01 | 467 | 103614 | 248045 | 79392262 |
Conjunctival cyst | 27.65 | 10.01 | 8 | 104073 | 64 | 79640243 |
Superinfection | 27.54 | 10.01 | 33 | 104048 | 4869 | 79635438 |
Hypoaesthesia | 27.41 | 10.01 | 356 | 103725 | 178996 | 79461311 |
Lung consolidation | 27.39 | 10.01 | 45 | 104036 | 8902 | 79631405 |
Heart rate decreased | 27.15 | 10.01 | 31 | 104050 | 70285 | 79570022 |
VIth nerve paralysis | 27.01 | 10.01 | 20 | 104061 | 1604 | 79638703 |
Drug resistance | 26.99 | 10.01 | 118 | 103963 | 42095 | 79598212 |
Adjustment disorder with depressed mood | 26.88 | 10.01 | 45 | 104036 | 9041 | 79631266 |
Trichomegaly | 26.78 | 10.01 | 9 | 104072 | 123 | 79640184 |
Suicide attempt | 26.50 | 10.01 | 42 | 104039 | 82890 | 79557417 |
Thrombocytopenia | 26.08 | 10.01 | 221 | 103860 | 265038 | 79375269 |
Abdominal discomfort | 26.06 | 10.01 | 466 | 103615 | 250261 | 79390046 |
Weight increased | 25.99 | 10.01 | 234 | 103847 | 277152 | 79363155 |
Injection site pain | 25.85 | 10.01 | 85 | 103996 | 129753 | 79510554 |
Pruritus | 25.80 | 10.01 | 686 | 103395 | 393962 | 79246345 |
Transplant failure | 25.67 | 10.01 | 31 | 104050 | 4610 | 79635697 |
Seizure | 25.67 | 10.01 | 143 | 103938 | 188691 | 79451616 |
Urethritis mycoplasmal | 25.56 | 10.01 | 6 | 104075 | 18 | 79640289 |
IIIrd nerve injury | 25.28 | 10.01 | 5 | 104076 | 4 | 79640303 |
Metabolic acidosis | 25.25 | 10.01 | 43 | 104038 | 82486 | 79557821 |
Neutropenia | 25.12 | 10.01 | 247 | 103834 | 287463 | 79352844 |
Muscle spasms | 25.11 | 10.01 | 343 | 103738 | 174387 | 79465920 |
Factitious disorder | 25.03 | 10.01 | 9 | 104072 | 152 | 79640155 |
Chronic obstructive pulmonary disease | 24.99 | 10.01 | 194 | 103887 | 85225 | 79555082 |
Somnolence | 24.92 | 10.01 | 196 | 103885 | 238785 | 79401522 |
Product use in unapproved indication | 24.86 | 10.01 | 462 | 103619 | 249897 | 79390410 |
Gastritis erosive | 24.77 | 10.01 | 48 | 104033 | 10799 | 79629508 |
Periarticular thenar erythema with onycholysis | 24.76 | 10.01 | 7 | 104074 | 51 | 79640256 |
Blood cholesterol increased | 24.41 | 10.01 | 190 | 103891 | 83530 | 79556777 |
Neutrophil count decreased | 24.37 | 10.01 | 54 | 104027 | 93905 | 79546402 |
Dermatitis bullous | 24.35 | 10.01 | 56 | 104025 | 14189 | 79626118 |
Hemiparesis | 24.16 | 10.01 | 7 | 104074 | 33726 | 79606581 |
Posterior reversible encephalopathy syndrome | 24.00 | 10.01 | 3 | 104078 | 26278 | 79614029 |
Tinnitus | 23.97 | 10.01 | 118 | 103963 | 44215 | 79596092 |
White blood cell count decreased | 23.78 | 10.01 | 146 | 103935 | 188142 | 79452165 |
Adverse drug reaction | 23.59 | 10.01 | 158 | 103923 | 66234 | 79574073 |
Gastrointestinal haemorrhage | 23.43 | 10.01 | 106 | 103975 | 147613 | 79492694 |
Jaundice | 23.37 | 10.01 | 134 | 103947 | 53215 | 79587092 |
Oesophageal irritation | 23.30 | 10.01 | 8 | 104073 | 117 | 79640190 |
Skin exfoliation | 23.23 | 10.01 | 137 | 103944 | 54963 | 79585344 |
Autoimmune hepatitis | 23.17 | 10.01 | 49 | 104032 | 11734 | 79628573 |
Drug-induced liver injury | 22.68 | 10.01 | 156 | 103925 | 65961 | 79574346 |
Overlap syndrome | 22.61 | 10.01 | 15 | 104066 | 1009 | 79639298 |
Malaria | 22.49 | 10.01 | 11 | 104070 | 411 | 79639896 |
Hypokalaemia | 22.46 | 10.01 | 104 | 103977 | 143936 | 79496371 |
Folliculitis | 22.27 | 10.01 | 136 | 103945 | 55244 | 79585063 |
Joint dislocation | 22.02 | 10.01 | 60 | 104021 | 16879 | 79623428 |
Device capturing issue | 21.69 | 10.01 | 6 | 104075 | 40 | 79640267 |
Bronchial hyperreactivity | 21.39 | 10.01 | 23 | 104058 | 3017 | 79637290 |
Benign prostatic hyperplasia | 21.35 | 10.01 | 47 | 104034 | 11565 | 79628742 |
Visual impairment | 21.02 | 10.01 | 198 | 103883 | 91933 | 79548374 |
Keratitis | 20.92 | 10.01 | 27 | 104054 | 4295 | 79636012 |
Toxic epidermal necrolysis | 20.87 | 10.01 | 114 | 103967 | 44467 | 79595840 |
Multiple sclerosis relapse | 20.85 | 10.01 | 18 | 104063 | 46515 | 79593792 |
Erosive oesophagitis | 20.62 | 10.01 | 22 | 104059 | 2860 | 79637447 |
Periorbital swelling | 20.53 | 10.01 | 22 | 104059 | 2874 | 79637433 |
Acute generalised exanthematous pustulosis | 20.35 | 10.01 | 59 | 104022 | 17195 | 79623112 |
Antinuclear antibody negative | 20.19 | 10.01 | 5 | 104076 | 20 | 79640287 |
Aggression | 20.18 | 10.01 | 22 | 104059 | 50936 | 79589371 |
Sinusitis | 20.18 | 10.01 | 363 | 103718 | 195138 | 79445169 |
Intentional product use issue | 20.01 | 10.01 | 294 | 103787 | 151818 | 79488489 |
Pneumonia aspiration | 19.48 | 10.01 | 36 | 104045 | 66931 | 79573376 |
Acute myocardial infarction | 19.38 | 10.01 | 45 | 104036 | 76991 | 79563316 |
Medical device discomfort | 19.38 | 10.01 | 17 | 104064 | 1737 | 79638570 |
Respiratory depression | 19.31 | 10.01 | 6 | 104075 | 27624 | 79612683 |
Breast cancer | 19.26 | 10.01 | 10 | 104071 | 33771 | 79606536 |
Chest injury | 19.25 | 10.01 | 21 | 104060 | 2800 | 79637507 |
Acne conglobata | 19.13 | 10.01 | 5 | 104076 | 26 | 79640281 |
Painful respiration | 19.00 | 10.01 | 23 | 104058 | 3430 | 79636877 |
Scar | 18.93 | 10.01 | 53 | 104028 | 15143 | 79625164 |
Myelosuppression | 18.78 | 10.01 | 15 | 104066 | 40281 | 79600026 |
Skin hyperpigmentation | 18.77 | 10.01 | 34 | 104047 | 7269 | 79633038 |
Road traffic accident | 18.69 | 10.01 | 109 | 103972 | 43555 | 79596752 |
Cytokine release syndrome | 18.61 | 10.01 | 12 | 104069 | 35986 | 79604321 |
Lactic acidosis | 18.60 | 10.01 | 40 | 104041 | 70319 | 79569988 |
Premature delivery | 18.49 | 10.01 | 4 | 104077 | 23463 | 79616844 |
Dehydration | 18.48 | 10.01 | 221 | 103860 | 247966 | 79392341 |
Gait inability | 18.46 | 10.01 | 136 | 103945 | 58781 | 79581526 |
Disease progression | 18.38 | 10.01 | 153 | 103928 | 184209 | 79456098 |
Hepatic function abnormal | 18.16 | 10.01 | 43 | 104038 | 73064 | 79567243 |
Headache | 18.07 | 10.01 | 1034 | 103047 | 652738 | 78987569 |
Sleep disorder due to a general medical condition | 17.99 | 10.01 | 50 | 104031 | 14227 | 79626080 |
Emotional distress | 17.91 | 10.01 | 101 | 103980 | 39868 | 79600439 |
Suicidal ideation | 17.89 | 10.01 | 165 | 103916 | 76175 | 79564132 |
Penile erythema | 17.88 | 10.01 | 7 | 104074 | 151 | 79640156 |
Injection site haemorrhage | 17.84 | 10.01 | 7 | 104074 | 27863 | 79612444 |
Sedation | 17.82 | 10.01 | 25 | 104056 | 51870 | 79588437 |
Infection | 17.79 | 10.01 | 427 | 103654 | 241285 | 79399022 |
Drug intolerance | 17.78 | 10.01 | 461 | 103620 | 263658 | 79376649 |
C-reactive protein abnormal | 17.72 | 10.01 | 116 | 103965 | 48251 | 79592056 |
Nodular vasculitis | 17.62 | 10.01 | 5 | 104076 | 37 | 79640270 |
Internal injury | 17.61 | 10.01 | 9 | 104072 | 370 | 79639937 |
Apparent death | 17.28 | 10.01 | 20 | 104061 | 2845 | 79637462 |
Symmetrical drug-related intertriginous and flexural exanthema | 17.23 | 10.01 | 12 | 104069 | 874 | 79639433 |
Ischaemic stroke | 17.19 | 10.01 | 11 | 104070 | 33120 | 79607187 |
Pulmonary function test abnormal | 17.17 | 10.01 | 24 | 104057 | 4120 | 79636187 |
Immunosuppressant drug level increased | 17.13 | 10.01 | 37 | 104044 | 8990 | 79631317 |
Oral candidiasis | 16.84 | 10.01 | 80 | 104001 | 29548 | 79610759 |
Diabetic ketoacidosis | 16.80 | 10.01 | 12 | 104069 | 34110 | 79606197 |
Angina pectoris | 16.72 | 10.01 | 26 | 104055 | 51706 | 79588601 |
Erythema nodosum | 16.62 | 10.01 | 27 | 104054 | 5290 | 79635017 |
Rebound effect | 16.53 | 10.01 | 32 | 104049 | 7194 | 79633113 |
Skin odour abnormal | 16.49 | 10.01 | 17 | 104064 | 2124 | 79638183 |
Flashback | 16.43 | 10.01 | 8 | 104073 | 296 | 79640011 |
Infusion related reaction | 16.39 | 10.01 | 207 | 103874 | 230030 | 79410277 |
SLE arthritis | 16.36 | 10.01 | 10 | 104071 | 583 | 79639724 |
Periostosis | 16.36 | 10.01 | 4 | 104077 | 15 | 79640292 |
Hallucinations, mixed | 16.33 | 10.01 | 31 | 104050 | 6868 | 79633439 |
Laryngitis | 16.25 | 10.01 | 52 | 104029 | 15987 | 79624320 |
Cytomegalovirus infection | 16.24 | 10.01 | 19 | 104062 | 42625 | 79597682 |
Distal intestinal obstruction syndrome | 16.11 | 10.01 | 11 | 104070 | 776 | 79639531 |
Melanocytic naevus | 16.10 | 10.01 | 25 | 104056 | 4716 | 79635591 |
Wound infection | 16.05 | 10.01 | 68 | 104013 | 23923 | 79616384 |
Hepatitis chronic active | 15.96 | 10.01 | 7 | 104074 | 203 | 79640104 |
Neuroleptic malignant syndrome | 15.95 | 10.01 | 8 | 104073 | 27551 | 79612756 |
Cognitive disorder | 15.92 | 10.01 | 43 | 104038 | 69883 | 79570424 |
Cholecystitis chronic | 15.90 | 10.01 | 38 | 104043 | 9868 | 79630439 |
Radiation fibrosis - lung | 15.86 | 10.01 | 5 | 104076 | 55 | 79640252 |
Respiratory arrest | 15.82 | 10.01 | 32 | 104049 | 57518 | 79582789 |
Aspartate aminotransferase increased | 15.73 | 10.01 | 111 | 103970 | 138530 | 79501777 |
Anuria | 15.67 | 10.01 | 4 | 104077 | 20959 | 79619348 |
Facet joint syndrome | 15.67 | 10.01 | 41 | 104040 | 11261 | 79629046 |
Wrong technique in product usage process | 15.66 | 10.01 | 47 | 104034 | 73828 | 79566479 |
Rash pustular | 15.65 | 10.01 | 41 | 104040 | 11270 | 79629037 |
Tendon discomfort | 15.63 | 10.01 | 9 | 104072 | 470 | 79639837 |
Cardiogenic shock | 15.62 | 10.01 | 19 | 104062 | 41895 | 79598412 |
Rosacea | 15.58 | 10.01 | 23 | 104058 | 4149 | 79636158 |
Helicobacter infection | 15.50 | 10.01 | 149 | 103932 | 69555 | 79570752 |
Creatinine renal clearance decreased | 15.47 | 10.01 | 3 | 104078 | 18999 | 79621308 |
Ureaplasma infection | 15.41 | 10.01 | 12 | 104069 | 1038 | 79639269 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 15.40 | 10.01 | 20 | 104061 | 3201 | 79637106 |
Tendon pain | 15.39 | 10.01 | 27 | 104054 | 5631 | 79634676 |
Altered state of consciousness | 15.16 | 10.01 | 21 | 104060 | 43801 | 79596506 |
Poisoning | 15.14 | 10.01 | 7 | 104074 | 25265 | 79615042 |
Hypercholesterolaemia | 15.10 | 10.01 | 65 | 104016 | 23030 | 79617277 |
Disease recurrence | 15.09 | 10.01 | 104 | 103977 | 44005 | 79596302 |
Acute myeloid leukaemia | 15.03 | 10.01 | 11 | 104070 | 30874 | 79609433 |
Chest pain | 14.93 | 10.01 | 478 | 103603 | 281826 | 79358481 |
Arthritis gonococcal | 14.85 | 10.01 | 3 | 104078 | 3 | 79640304 |
Neoplasm progression | 14.84 | 10.01 | 28 | 104053 | 51654 | 79588653 |
Lower respiratory tract infection | 14.79 | 10.01 | 244 | 103837 | 128976 | 79511331 |
Hypercalcaemia | 14.77 | 10.01 | 17 | 104064 | 38413 | 79601894 |
Ear infection | 14.76 | 10.01 | 86 | 103995 | 34346 | 79605961 |
Prostate cancer | 14.75 | 10.01 | 13 | 104068 | 33255 | 79607052 |
Mucosal inflammation | 14.68 | 10.01 | 50 | 104031 | 75530 | 79564777 |
Injection site reaction | 14.60 | 10.01 | 31 | 104050 | 54754 | 79585553 |
Noninfective oophoritis | 14.51 | 10.01 | 5 | 104076 | 74 | 79640233 |
Rash pruritic | 14.42 | 10.01 | 150 | 103931 | 71479 | 79568828 |
Colitis ulcerative | 14.40 | 10.01 | 86 | 103995 | 34656 | 79605651 |
Blood pressure decreased | 14.24 | 10.01 | 74 | 104007 | 99392 | 79540915 |
Corneal neovascularisation | 14.21 | 10.01 | 6 | 104075 | 158 | 79640149 |
Dizziness | 14.21 | 10.01 | 831 | 103250 | 525610 | 79114697 |
Hepatic cirrhosis | 14.21 | 10.01 | 86 | 103995 | 34820 | 79605487 |
Accidental exposure to product | 14.18 | 10.01 | 12 | 104069 | 31310 | 79608997 |
Pneumococcal infection | 14.17 | 10.01 | 11 | 104070 | 947 | 79639360 |
Papillary renal cell carcinoma | 14.15 | 10.01 | 7 | 104074 | 268 | 79640039 |
Dysphagia | 14.12 | 10.01 | 231 | 103850 | 121905 | 79518402 |
Medical device pain | 14.09 | 10.01 | 13 | 104068 | 1418 | 79638889 |
Herpes zoster | 14.04 | 10.01 | 68 | 104013 | 93015 | 79547292 |
Amyloid arthropathy | 14.04 | 10.01 | 9 | 104072 | 571 | 79639736 |
Product prescribing error | 14.03 | 10.01 | 23 | 104058 | 44790 | 79595517 |
Live birth | 14.03 | 10.01 | 55 | 104026 | 18689 | 79621618 |
Eosinophilic pneumonia | 14.01 | 10.01 | 25 | 104056 | 5285 | 79635022 |
SAPHO syndrome | 13.98 | 10.01 | 8 | 104073 | 413 | 79639894 |
Tumour lysis syndrome | 13.78 | 10.01 | 7 | 104074 | 23932 | 79616375 |
Gastroduodenal haemorrhage | 13.71 | 10.01 | 7 | 104074 | 287 | 79640020 |
Colorectal cancer metastatic | 13.68 | 10.01 | 12 | 104069 | 1226 | 79639081 |
Foot deformity | 13.68 | 10.01 | 65 | 104016 | 24009 | 79616298 |
Drug monitoring procedure not performed | 13.65 | 10.01 | 11 | 104070 | 1000 | 79639307 |
Post treatment Lyme disease syndrome | 13.64 | 10.01 | 3 | 104078 | 6 | 79640301 |
Medical device site hyperaesthesia | 13.64 | 10.01 | 3 | 104078 | 6 | 79640301 |
PaO2/FiO2 ratio decreased | 13.61 | 10.01 | 4 | 104077 | 34 | 79640273 |
Tubulointerstitial nephritis | 13.58 | 10.01 | 91 | 103990 | 38144 | 79602163 |
Dermatomyositis | 13.57 | 10.01 | 20 | 104061 | 3603 | 79636704 |
Abscess limb | 13.56 | 10.01 | 29 | 104052 | 6998 | 79633309 |
Blood urea increased | 13.52 | 10.01 | 27 | 104054 | 48763 | 79591544 |
Blood potassium increased | 13.52 | 10.01 | 11 | 104070 | 29264 | 79611043 |
Infertility female | 13.50 | 10.01 | 8 | 104073 | 441 | 79639866 |
Underdose | 13.48 | 10.01 | 14 | 104067 | 33137 | 79607170 |
Palmar-plantar erythrodysaesthesia syndrome | 13.46 | 10.01 | 14 | 104067 | 33120 | 79607187 |
Neoplasm malignant | 13.43 | 10.01 | 13 | 104068 | 31797 | 79608510 |
Walking aid user | 13.24 | 10.01 | 36 | 104045 | 10112 | 79630195 |
Rhinocerebral mucormycosis | 13.21 | 10.01 | 11 | 104070 | 1047 | 79639260 |
Pharyngeal oedema | 13.21 | 10.01 | 49 | 104032 | 16223 | 79624084 |
Pathogen resistance | 13.19 | 10.01 | 45 | 104036 | 14297 | 79626010 |
Granuloma annulare | 13.18 | 10.01 | 9 | 104072 | 635 | 79639672 |
Bronchiectasis | 13.12 | 10.01 | 61 | 104020 | 22325 | 79617982 |
Weight decreased | 13.11 | 10.01 | 358 | 103723 | 354840 | 79285467 |
Chronic cutaneous lupus erythematosus | 13.10 | 10.01 | 8 | 104073 | 466 | 79639841 |
Eye pain | 13.09 | 10.01 | 89 | 103992 | 37489 | 79602818 |
Knee arthroplasty | 13.08 | 10.01 | 99 | 103982 | 43149 | 79597158 |
Post infection glomerulonephritis | 13.08 | 10.01 | 5 | 104076 | 101 | 79640206 |
Pulmonary oedema | 13.01 | 10.01 | 65 | 104016 | 88189 | 79552118 |
Haematocrit decreased | 13 | 10.01 | 39 | 104042 | 61273 | 79579034 |
Vasculitis | 12.99 | 10.01 | 66 | 104015 | 25036 | 79615271 |
Pulmonary fibrosis | 12.79 | 10.01 | 100 | 103981 | 44012 | 79596295 |
Sunburn | 12.72 | 10.01 | 20 | 104061 | 3813 | 79636494 |
Drug dependence | 12.69 | 10.01 | 21 | 104060 | 40748 | 79599559 |
Retinopathy hypertensive | 12.60 | 10.01 | 8 | 104073 | 499 | 79639808 |
Naevoid melanoma | 12.54 | 10.01 | 3 | 104078 | 10 | 79640297 |
Rash maculo-papular | 12.53 | 10.01 | 120 | 103961 | 55958 | 79584349 |
Gastrointestinal bacterial overgrowth | 12.53 | 10.01 | 9 | 104072 | 689 | 79639618 |
Extrapyramidal disorder | 12.51 | 10.01 | 7 | 104074 | 22672 | 79617635 |
Angina bullosa haemorrhagica | 12.50 | 10.01 | 6 | 104075 | 215 | 79640092 |
Lipoedema | 12.47 | 10.01 | 6 | 104075 | 216 | 79640091 |
Secondary amyloidosis | 12.47 | 10.01 | 6 | 104075 | 216 | 79640091 |
Oxygen saturation decreased | 12.45 | 10.01 | 108 | 103973 | 128939 | 79511368 |
Full blood count abnormal | 12.43 | 10.01 | 93 | 103988 | 40381 | 79599926 |
Ventricular fibrillation | 12.40 | 10.01 | 14 | 104067 | 31912 | 79608395 |
Blood lactate dehydrogenase increased | 12.36 | 10.01 | 20 | 104061 | 39150 | 79601157 |
Loss of consciousness | 12.32 | 10.01 | 150 | 103931 | 167793 | 79472514 |
Genital haemorrhage | 12.28 | 10.01 | 26 | 104055 | 6229 | 79634078 |
Perforation | 12.23 | 10.01 | 12 | 104069 | 1414 | 79638893 |
Therapy partial responder | 12.18 | 10.01 | 50 | 104031 | 17347 | 79622960 |
Sleep apnoea syndrome | 12.11 | 10.01 | 18 | 104063 | 36460 | 79603847 |
Herpes simplex oesophagitis | 12.08 | 10.01 | 7 | 104074 | 370 | 79639937 |
Hip arthroplasty | 12.05 | 10.01 | 84 | 103997 | 35672 | 79604635 |
Tendon disorder | 12.01 | 10.01 | 28 | 104053 | 7158 | 79633149 |
Heart rate irregular | 11.98 | 10.01 | 15 | 104066 | 32664 | 79607643 |
Urinary tract infection | 11.94 | 10.01 | 270 | 103811 | 274242 | 79366065 |
Renal disorder | 11.93 | 10.01 | 23 | 104058 | 42082 | 79598225 |
Bronchitis | 11.90 | 10.01 | 238 | 103843 | 130406 | 79509901 |
Breast cancer stage II | 11.82 | 10.01 | 30 | 104051 | 8090 | 79632217 |
Red blood cell burr cells present | 11.81 | 10.01 | 4 | 104077 | 56 | 79640251 |
Dyspnoea | 11.80 | 10.01 | 1284 | 102797 | 855741 | 78784566 |
Interleukin-2 receptor increased | 11.80 | 10.01 | 6 | 104075 | 244 | 79640063 |
Ischaemic cardiomyopathy | 11.80 | 10.01 | 29 | 104052 | 7666 | 79632641 |
Laryngeal injury | 11.74 | 10.01 | 3 | 104078 | 14 | 79640293 |
Anaphylactic shock | 11.72 | 10.01 | 18 | 104063 | 35978 | 79604329 |
Respiratory tract infection bacterial | 11.70 | 10.01 | 14 | 104067 | 2063 | 79638244 |
Infective exacerbation of bronchiectasis | 11.69 | 10.01 | 9 | 104072 | 765 | 79639542 |
Stoma site discomfort | 11.66 | 10.01 | 5 | 104076 | 137 | 79640170 |
Musculoskeletal stiffness | 11.63 | 10.01 | 305 | 103776 | 174703 | 79465604 |
Alanine aminotransferase increased | 11.62 | 10.01 | 146 | 103935 | 162424 | 79477883 |
Ear pain | 11.54 | 10.01 | 78 | 104003 | 32791 | 79607516 |
Dermatitis atopic | 11.49 | 10.01 | 34 | 104047 | 10022 | 79630285 |
Gamma-glutamyltransferase increased | 11.44 | 10.01 | 35 | 104046 | 54645 | 79585662 |
Rash morbilliform | 11.43 | 10.01 | 25 | 104056 | 6125 | 79634182 |
Arthritis allergic | 11.26 | 10.01 | 3 | 104078 | 17 | 79640290 |
Cerebral infarction | 11.24 | 10.01 | 27 | 104054 | 45649 | 79594658 |
Ruptured ectopic pregnancy | 11.21 | 10.01 | 7 | 104074 | 424 | 79639883 |
Therapy non-responder | 11.20 | 10.01 | 176 | 103905 | 92129 | 79548178 |
Tuberculosis | 11.17 | 10.01 | 3 | 104078 | 15195 | 79625112 |
Respiratory tract infection viral | 11.17 | 10.01 | 20 | 104061 | 4239 | 79636068 |
Skin fissures | 11.15 | 10.01 | 40 | 104041 | 13033 | 79627274 |
Hypocalcaemia | 11.14 | 10.01 | 31 | 104050 | 49893 | 79590414 |
Penile rash | 11.11 | 10.01 | 3 | 104078 | 18 | 79640289 |
Acne | 11.07 | 10.01 | 67 | 104014 | 27123 | 79613184 |
Sudden death | 10.98 | 10.01 | 8 | 104073 | 22503 | 79617804 |
Cinchonism | 10.98 | 10.01 | 3 | 104078 | 19 | 79640288 |
Foreign body reaction | 10.88 | 10.01 | 5 | 104076 | 162 | 79640145 |
Status epilepticus | 10.84 | 10.01 | 10 | 104071 | 25031 | 79615276 |
Infusion site erythema | 10.82 | 10.01 | 32 | 104049 | 9428 | 79630879 |
Dry skin | 10.81 | 10.01 | 136 | 103945 | 67859 | 79572448 |
Glomerulonephritis rapidly progressive | 10.78 | 10.01 | 12 | 104069 | 1636 | 79638671 |
Asthenia | 10.75 | 10.01 | 552 | 103529 | 511137 | 79129170 |
Ototoxicity | 10.75 | 10.01 | 17 | 104064 | 3257 | 79637050 |
Ileus | 10.73 | 10.01 | 11 | 104070 | 26200 | 79614107 |
Splenic infarction | 10.64 | 10.01 | 18 | 104063 | 3646 | 79636661 |
Abdominal pain upper | 10.56 | 10.01 | 374 | 103707 | 223445 | 79416862 |
Depressed mood | 10.47 | 10.01 | 103 | 103978 | 48377 | 79591930 |
Papule | 10.40 | 10.01 | 27 | 104054 | 7380 | 79632927 |
Mydriasis | 10.39 | 10.01 | 5 | 104076 | 17638 | 79622669 |
Frequent bowel movements | 10.38 | 10.01 | 14 | 104067 | 29525 | 79610782 |
Hypokinesia | 10.35 | 10.01 | 6 | 104075 | 19054 | 79621253 |
Orthostatic hypotension | 10.34 | 10.01 | 38 | 104043 | 56126 | 79584181 |
Fracture | 10.31 | 10.01 | 8 | 104073 | 21793 | 79618514 |
Diabetes mellitus | 10.30 | 10.01 | 60 | 104021 | 78330 | 79561977 |
Device breakage | 10.27 | 10.01 | 34 | 104047 | 10641 | 79629666 |
Ocular surface squamous neoplasia | 10.26 | 10.01 | 3 | 104078 | 25 | 79640282 |
Anal candidiasis | 10.26 | 10.01 | 3 | 104078 | 25 | 79640282 |
Crystal nephropathy | 10.22 | 10.01 | 11 | 104070 | 1444 | 79638863 |
Femur fracture | 10.19 | 10.01 | 22 | 104059 | 38630 | 79601677 |
Interstitial lung disease | 10.10 | 10.01 | 96 | 103985 | 112504 | 79527803 |
Oesophagitis ulcerative | 10.09 | 10.01 | 10 | 104071 | 1193 | 79639114 |
Small intestine ulcer | 10.08 | 10.01 | 8 | 104073 | 711 | 79639596 |
Growth of eyelashes | 10.07 | 10.01 | 5 | 104076 | 193 | 79640114 |
Onychalgia | 10.06 | 10.01 | 9 | 104072 | 943 | 79639364 |
None
Source | Code | Description |
---|---|---|
ATC | A01AB22 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
ATC | J01AA02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
FDA Chemical/Ingredient | N0000007948 | Tetracyclines |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000962 | Antimalarials |
MeSH PA | D000977 | Antiparasitic Agents |
MeSH PA | D000981 | Antiprotozoal Agents |
FDA EPC | N0000175882 | Tetracycline-class Drug |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:38068 | antimalarials |
CHEBI has role | CHEBI:50846 | Immunologic factor |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
CHEBI has role | CHEBI:176497 | geroprotectors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Trachoma | indication | 2576002 | DOID:11265 |
Listeriosis | indication | 4241002 | DOID:11573 |
Inhalational anthrax | indication | 11389007 | |
Actinomycotic infection | indication | 11817007 | DOID:8478 |
Gonorrhea | indication | 15628003 | DOID:7551 |
Tularemia | indication | 19265001 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Murine typhus | indication | 25668000 | DOID:11256 |
Granuloma inguinale | indication | 28867007 | DOID:9113 |
Acute gonococcal urethritis | indication | 29864006 | |
Acute gonococcal epididymo-orchitis | indication | 30168008 | DOID:10802 |
Bronchitis | indication | 32398004 | DOID:6132 |
Sinusitis | indication | 36971009 | |
Disease caused by rickettsiae | indication | 37246009 | |
Louse-borne typhus | indication | 39111003 | DOID:11256 |
Gonorrhea of rectum | indication | 42746002 | |
Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
Brill-Zinsser disease | indication | 47761007 | DOID:11254 |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Cholera | indication | 63650001 | DOID:1498 |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Yaws | indication | 70647001 | DOID:10371 |
Gonorrhea of pharynx | indication | 74372003 | |
Rickettsialpox | indication | 75096007 | DOID:11103 |
Ornithosis | indication | 75116005 | DOID:11262 |
Acute bacterial sinusitis | indication | 75498004 | |
Brucellosis | indication | 75702008 | DOID:11077 |
Syphilis | indication | 76272004 | |
Nongonococcal urethritis | indication | 84619001 | |
Cutaneous anthrax | indication | 84980006 | DOID:7426 |
Acne vulgaris | indication | 88616000 | |
Q fever endocarditis | indication | 95890006 | |
Chlamydial infection | indication | 105629000 | |
Gastrointestinal anthrax | indication | 111798006 | DOID:13386 |
Rocky Mountain spotted fever | indication | 186772009 | |
Boutonneuse fever | indication | 186774005 | DOID:14095 |
Q fever | indication | 186788009 | DOID:11100 |
Lymphogranuloma venereum | indication | 186946009 | DOID:13819 |
Inclusion conjunctivitis | indication | 266109000 | |
Bartonellosis | indication | 266123003 | DOID:11102 |
Chancroid | indication | 266143009 | DOID:13778 |
Scrub typhus | indication | 271425001 | DOID:13371 |
Bacterial urinary infection | indication | 312124009 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Anthrax | indication | 409498004 | DOID:7427 |
Relapsing fever | indication | 420079008 | DOID:13034 |
Chlamydia trachomatis infection of genital structure | indication | 428015005 | |
Periodontitis Adjunct Therapy | indication | ||
Chloroquine-Resistant Plasmodium Falciparum Malaria Prevention | indication | ||
Typhus Infections | indication | ||
Disseminated Gonococcal Infection | indication | ||
Severe Recalcitrant Nodular Rosacea | indication | ||
Rectal Chlamydia Trachomatis Infection | indication | ||
Traveler's diarrhea | off-label use | 11840006 | |
Gingivostomatitis | off-label use | 20607006 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Vivax malaria | off-label use | 27052006 | DOID:12978 |
Lyme arthritis | off-label use | 33937009 | |
Enterocolitis | off-label use | 43752006 | |
Plague | off-label use | 58750007 | DOID:3482 |
Malaria | off-label use | 61462000 | DOID:12365 |
Ehrlichiosis | off-label use | 77361002 | |
Leptospirosis | off-label use | 77377001 | DOID:2297 |
Lyme carditis | off-label use | 77863005 | |
Atypical mycobacterial infection | off-label use | 111812000 | |
Ocular rosacea | off-label use | 200933006 | |
Chlamydial epididymitis | off-label use | 236767000 | |
Rosacea | off-label use | 398909004 | DOID:8881 |
Sexual Transmitted Disease Exposure from Sexual Assault | off-label use | ||
Postexposure Plague Prophylaxis | off-label use | ||
Lyme Disease Prevention | off-label use | ||
Pleural Malignant Effusions | off-label use | ||
Chloroquine Resistant Plasmodium Falciparum Malaria | off-label use | ||
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Pregnancy, function | contraindication | 289908002 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
Species | Use | Relation |
---|---|---|
Dogs | Periodontal disease | Indication |
Product | Applicant | Ingredients |
---|---|---|
Doxirobe Gel | Zoetis Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.23 | acidic |
pKa2 | 7.13 | acidic |
pKa3 | 9.78 | acidic |
pKa4 | 11.26 | acidic |
pKa5 | 12.46 | acidic |
pKa6 | 13.08 | acidic |
pKa7 | 9.07 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
40MG | ORACEA | GALDERMA LABS LP | N050805 | May 26, 2006 | RX | CAPSULE | ORAL | 8394405 | April 7, 2024 | TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA |
40MG | ORACEA | GALDERMA LABS LP | N050805 | May 26, 2006 | RX | CAPSULE | ORAL | 8394406 | April 7, 2024 | TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA |
40MG | ORACEA | GALDERMA LABS LP | N050805 | May 26, 2006 | RX | CAPSULE | ORAL | 8470364 | April 7, 2024 | TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA |
40MG | ORACEA | GALDERMA LABS LP | N050805 | May 26, 2006 | RX | CAPSULE | ORAL | 8709478 | April 7, 2024 | TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA |
40MG | ORACEA | GALDERMA LABS LP | N050805 | May 26, 2006 | RX | CAPSULE | ORAL | 8206740 | Dec. 24, 2025 | TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA |
40MG | ORACEA | GALDERMA LABS LP | N050805 | May 26, 2006 | RX | CAPSULE | ORAL | 7749532 | Dec. 19, 2027 | TREATMENT OF ONLY INFLAMMATORY LESIONS (PAPULES AND PUSTULES) OF ROSACEA |
EQ 120MG BASE | DORYX MPC | MAYNE PHARMA | N050795 | May 20, 2016 | DISCN | TABLET, DELAYED RELEASE | ORAL | 9295652 | Oct. 23, 2034 | TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET |
EQ 60MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | DORYX MPC | MAYNE PHARMA | N050795 | May 20, 2016 | RX | TABLET, DELAYED RELEASE | ORAL | 9295652 | Oct. 23, 2034 | TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET |
EQ 120MG BASE | DORYX MPC | MAYNE PHARMA | N050795 | May 20, 2016 | DISCN | TABLET, DELAYED RELEASE | ORAL | 9446057 | Dec. 23, 2034 | TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET |
EQ 60MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | DORYX MPC | MAYNE PHARMA | N050795 | May 20, 2016 | RX | TABLET, DELAYED RELEASE | ORAL | 9446057 | Dec. 23, 2034 | TO TREAT OR PREVENT INFECTIONS CAUSED BY SUSCEPTIBLE BACTERIA USING DELAYED-RELEASE TABLETS CONSISTING OF DOXYCYCLINE HYCLATE COATED PELLETS IN A TABLET |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
72 kDa type IV collagenase | Enzyme | IC50 | 4.62 | CHEMBL | |||||
Stromelysin-1 | Enzyme | IC50 | 4.60 | CHEMBL | |||||
Neutrophil collagenase | Enzyme | INHIBITOR | IC50 | 4.60 | IUPHAR | ||||
Collagenase 3 | Enzyme | INHIBITOR | IC50 | 4.40 | CHEMBL | ||||
Matrilysin | Enzyme | INHIBITOR | Kd | 4.14 | IUPHAR | ||||
50S ribosomal protein L10 | Ribosomal protein | WOMBAT-PK | |||||||
Tetracycline resistance protein, class B | Transporter | IC50 | 5.04 | WOMBAT-PK | |||||
Zinc finger protein mex-5 | Cytosolic other | EC50 | 4.42 | WOMBAT-PK |
ID | Source |
---|---|
4017742 | VUID |
N0000146109 | NUI |
D00307 | KEGG_DRUG |
24390-14-5 | SECONDARY_CAS_RN |
94088-85-4 | SECONDARY_CAS_RN |
4017738 | VANDF |
4017740 | VANDF |
4017742 | VANDF |
C0013090 | UMLSCUI |
CHEBI:60648 | CHEBI |
DXT | PDB_CHEM_ID |
CHEMBL1200699 | ChEMBL_ID |
CHEMBL3989740 | ChEMBL_ID |
CHEMBL1200567 | ChEMBL_ID |
CHEMBL2364574 | ChEMBL_ID |
D004318 | MESH_DESCRIPTOR_UI |
DB00254 | DRUGBANK_ID |
6464 | IUPHAR_LIGAND_ID |
10592-13-9 | SECONDARY_CAS_RN |
N12000U13O | UNII |
54671203 | PUBCHEM_CID |
1543946 | RXNORM |
21502 | MMSL |
227071 | MMSL |
230639 | MMSL |
30716 | MMSL |
3375 | MMSL |
4641 | MMSL |
4642 | MMSL |
d00037 | MMSL |
002748 | NDDF |
002749 | NDDF |
002750 | NDDF |
006525 | NDDF |
10504007 | SNOMEDCT_US |
372478003 | SNOMEDCT_US |
63559007 | SNOMEDCT_US |
71417000 | SNOMEDCT_US |
734475000 | SNOMEDCT_US |
CHEMBL1256723 | ChEMBL_ID |
17086-28-1 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Vibramycin Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0950 | CAPSULE | 100 mg | ORAL | NDA | 28 sections |
Vibramycin Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0950 | CAPSULE | 100 mg | ORAL | NDA | 28 sections |
Vibramycin Monohydrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0970 | POWDER, FOR SUSPENSION | 25 mg | ORAL | NDA | 28 sections |
Vibramycin Monohydrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0970 | POWDER, FOR SUSPENSION | 25 mg | ORAL | NDA | 28 sections |
Vibramycin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0971 | SYRUP | 50 mg | ORAL | NDA | 28 sections |
Vibramycin Calcium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0971 | SYRUP | 50 mg | ORAL | NDA | 28 sections |
Vibra-Tabs | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0990 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 28 sections |
Vibra-Tabs | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0990 | TABLET, FILM COATED | 100 mg | ORAL | NDA | 28 sections |
Doxycycline | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1327 | CAPSULE | 150 mg | ORAL | ANDA | 28 sections |
Doxycycline | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-2112 | TABLET, COATED | 100 mg | ORAL | ANDA | 25 sections |
Doxycycline | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-2112 | TABLET, COATED | 100 mg | ORAL | ANDA | 25 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-3141 | CAPSULE, GELATIN COATED | 50 mg | ORAL | ANDA | 23 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-3141 | CAPSULE, GELATIN COATED | 50 mg | ORAL | ANDA | 23 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-3142 | CAPSULE, GELATIN COATED | 100 mg | ORAL | ANDA | 23 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-3142 | CAPSULE, GELATIN COATED | 100 mg | ORAL | ANDA | 23 sections |
Doxycycline | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9381 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 15 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9802 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9802 | CAPSULE | 50 mg | ORAL | ANDA | 27 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9803 | CAPSULE | 100 mg | ORAL | ANDA | 27 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9803 | CAPSULE | 100 mg | ORAL | ANDA | 27 sections |
ORACEA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-3822 | CAPSULE | 40 mg | ORAL | NDA | 27 sections |
ORACEA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-3822 | CAPSULE | 40 mg | ORAL | NDA | 27 sections |
ORACEA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0299-3822 | CAPSULE | 40 mg | ORAL | NDA | 27 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4535 | TABLET, DELAYED RELEASE | 50 mg | ORAL | ANDA | 29 sections |
DOXYCYCLINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9855 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 11 sections |
DOXYCYCLINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9855 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 11 sections |
DOXYCYCLINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9855 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 11 sections |
Doxycyclate Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1481 | CAPSULE | 100 mg | ORAL | ANDA | 25 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7481 | CAPSULE | 100 mg | ORAL | ANDA | 22 sections |
Doxycycline Hyclate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7482 | TABLET | 100 mg | ORAL | ANDA | 24 sections |