doxorubicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 960 23214-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxorubicin
  • hydroxydaunomycin
  • hydroxydaunorubicin
  • rubidox
  • doxorubicin hydrochloride
  • liposomal doxorubicin
  • hydroxydaunorubicin hydrochloride
  • adriamycin
  • doxorubicin HCl
  • hydroxydaunorubicin HCl
  • adriacin
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
  • Molecular weight: 543.53
  • Formula: C27H29NO11
  • CLOGP: 0.26
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 6
  • TPSA: 206.07
  • ALOGS: -2.67
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.47 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.28 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 32 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.621 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 10.641 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 2.518 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 3.899 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 33.640 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 25.880 % High 1
herg hERG pIC50 4.624 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.941 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.251 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 18.530 % High 1
kinase-safety-class ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,ITK,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 42
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 9.016 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 8.395 High 1
mh-clint Mouse hepatocyte intrinsic clearance 6.761 High 1
mppb Mouse plasma protein binding (% unbound) 22.790 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 13.152 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.75
pppb Pig plasma protein binding (% unbound) 32.830 % High 1
rat-kpuu-brain Rat brain Kpuu 0.011 % High 1
rh-clint Rat hepatocyte intrinsic clearance 3.690 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 68.480 % High 1
rppb Rat plasma protein binding (% unbound) 18.400 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 99.770 uM High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1974 FDA
June 20, 1996 EMA BAXTER HOLDING B.V.
March 1, 1975 PMDA SANDOZ PHARMA K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 8039.50 13.42 4214 137292 154135 90332806
Neutropenia 3933.25 13.42 3056 138450 221848 90265093
Disease progression 3879.64 13.42 2629 138877 153986 90332955
Cardiotoxicity 1643.78 13.42 632 140874 10757 90476184
Acute myeloid leukaemia 1591.11 13.42 733 140773 19907 90467034
Mucosal inflammation 1407.74 13.42 961 140545 56664 90430277
Malignant neoplasm progression 1324.28 13.42 1193 140313 105677 90381264
Thrombocytopenia 1293.57 13.42 1610 139896 207115 90279826
Myelodysplastic syndrome 1221.63 13.42 614 140892 20289 90466652
Pancytopenia 1187.51 13.42 1184 140322 119079 90367862
Haematotoxicity 1121.22 13.42 494 141012 12041 90474900
Second primary malignancy 1102.75 13.42 462 141044 9916 90477025
Diffuse large B-cell lymphoma recurrent 1034.88 13.42 332 141174 3194 90483747
Anaemia 956.63 13.42 1857 139649 350945 90135996
Neoplasm progression 892.17 13.42 658 140848 43828 90443113
Cardiomyopathy 858.93 13.42 480 141026 19726 90467215
Myelosuppression 850.70 13.42 690 140816 52901 90434040
Ejection fraction decreased 797.38 13.42 502 141004 25751 90461190
Off label use 776.32 13.42 3581 137925 1098671 89388270
Palmar-plantar erythrodysaesthesia syndrome 767.38 13.42 502 141004 27521 90459420
Neuropathy peripheral 766.23 13.42 1005 140501 135965 90350976
Bone marrow failure 726.97 13.42 512 140994 31709 90455232
Leukopenia 702.98 13.42 826 140680 99884 90387057
Febrile bone marrow aplasia 694.97 13.42 328 141178 9410 90477531
Joint swelling 690.85 13.42 21 141485 503279 89983662
Hepatitis B reactivation 596.49 13.42 227 141279 3747 90483194
Cardiac failure 591.47 13.42 790 140716 108706 90378235
Pneumocystis jirovecii pneumonia 574.22 13.42 380 141126 21236 90465705
Cytopenia 548.31 13.42 341 141165 17108 90469833
Septic shock 537.60 13.42 660 140846 83500 90403441
Therapy partial responder 536.42 13.42 367 141139 21676 90465265
Systemic lupus erythematosus 532.90 13.42 6 141500 361890 90125051
Rheumatoid arthritis 521.01 13.42 9 141497 362605 90124336
Metastases to bone 512.90 13.42 378 141128 25127 90461814
Sepsis 503.89 13.42 961 140545 178853 90308088
Tumour lysis syndrome 485.03 13.42 269 141237 10883 90476058
Disease recurrence 484.89 13.42 430 141076 37223 90449718
Glossodynia 475.25 13.42 5 141501 321774 90165167
Synovitis 474.46 13.42 8 141498 329744 90157197
Abdominal discomfort 466.56 13.42 90 141416 477238 90009703
Arthropathy 460.43 13.42 28 141478 366214 90120727
Neutrophil count decreased 458.48 13.42 562 140944 70970 90415971
Pain 434.29 13.42 553 140953 995788 89491153
Metastases to liver 421.66 13.42 354 141152 28453 90458488
Arthralgia 421.33 13.42 359 141147 778163 89708778
Swelling 420.22 13.42 74 141432 418984 90067957
Nasopharyngitis 416.80 13.42 68 141438 407036 90079905
Contraindicated product administered 416.30 13.42 20 141486 320119 90166822
Wound 410.53 13.42 14 141492 302966 90183975
Left ventricular dysfunction 409.39 13.42 266 141240 14403 90472538
Peripheral swelling 386.84 13.42 86 141420 413020 90073921
Product use in unapproved indication 385.11 13.42 1277 140229 334959 90151982
Congestive cardiomyopathy 371.71 13.42 196 141310 7158 90479783
Neutropenic sepsis 365.19 13.42 269 141237 17861 90469080
Musculoskeletal stiffness 362.81 13.42 26 141480 296506 90190435
Pyrexia 361.34 13.42 2003 139503 658482 89828459
Headache 358.10 13.42 496 141010 862250 89624691
Pruritus 354.36 13.42 203 141303 541322 89945619
Fall 353.70 13.42 155 141351 481655 90005286
Drug hypersensitivity 353.42 13.42 141 141365 463468 90023473
Weight increased 353.14 13.42 107 141399 417820 90069121
Metastases to lung 351.11 13.42 250 141256 15741 90471200
Cytokine release syndrome 337.54 13.42 308 141198 27665 90459276
Therapeutic product effect decreased 334.83 13.42 26 141480 277545 90209396
Psoriatic arthropathy 330.62 13.42 5 141501 228330 90258611
Diffuse large B-cell lymphoma refractory 325.86 13.42 118 141388 1682 90485259
Ovarian failure 317.35 13.42 113 141393 1530 90485411
Product dose omission issue 302.29 13.42 47 141459 291640 90195301
Helicobacter infection 302.00 13.42 12 141494 226838 90260103
Bone pain 301.01 13.42 425 141081 61558 90425383
Fibromyalgia 296.60 13.42 5 141501 206264 90280677
Sinusitis 293.10 13.42 86 141420 343002 90143939
Urticaria 292.86 13.42 65 141441 312669 90174272
Ventricular dysfunction 292.05 13.42 134 141372 3597 90483344
Posterior reversible encephalopathy syndrome 289.33 13.42 256 141250 22083 90464858
Irritable bowel syndrome 286.65 13.42 8 141498 207440 90279501
Blood lactate dehydrogenase increased 284.87 13.42 271 141235 25661 90461280
Pericarditis 283.43 13.42 42 141464 270109 90216832
Folliculitis 281.93 13.42 8 141498 204345 90282596
Blood cholesterol increased 276.90 13.42 11 141495 208001 90278940
Neutropenic colitis 275.63 13.42 133 141373 4010 90482931
Hepatic enzyme increased 274.32 13.42 110 141396 360626 90126315
Contusion 270.71 13.42 36 141470 251180 90235761
Metastases to lymph nodes 264.15 13.42 186 141320 11503 90475438
Wheezing 264.14 13.42 31 141475 238049 90248892
Rash 258.78 13.42 535 140971 795565 89691376
Asthma 257.86 13.42 36 141470 242124 90244817
Multiple organ dysfunction syndrome 255.72 13.42 415 141091 67921 90419020
Impaired healing 253.69 13.42 33 141473 234166 90252775
Interstitial lung disease 251.32 13.42 438 141068 75967 90410974
Polyneuropathy 251.19 13.42 222 141284 19119 90467822
Discomfort 250.89 13.42 60 141446 274275 90212666
Injury 245.11 13.42 16 141490 197333 90289608
Staphylococcal bacteraemia 242.32 13.42 149 141357 7320 90479621
Pneumonitis 241.83 13.42 321 141185 43849 90443092
Neurotoxicity 240.87 13.42 227 141279 21240 90465701
Type 2 diabetes mellitus 239.63 13.42 21 141485 203223 90283718
Mobility decreased 234.93 13.42 52 141454 250682 90236259
Drug intolerance 234.82 13.42 212 141294 447379 90039562
Breast cancer metastatic 233.99 13.42 192 141314 14940 90472001
Ascites 229.80 13.42 326 141180 47414 90439527
Insomnia 229.58 13.42 117 141389 333357 90153584
Pleural effusion 222.00 13.42 520 140986 111471 90375470
Bone marrow disorder 212.86 13.42 101 141405 2931 90484010
Completed suicide 210.70 13.42 3 141503 145055 90341886
Psoriasis 210.66 13.42 4 141502 147750 90339191
Platelet count decreased 209.02 13.42 576 140930 136393 90350548
Respiratory failure 208.20 13.42 525 140981 117893 90369048
White blood cell count decreased 206.58 13.42 652 140854 166457 90320484
Osteoarthritis 206.25 13.42 30 141476 195700 90291241
Lower respiratory tract infection 204.74 13.42 68 141438 250591 90236350
Acute promyelocytic leukaemia 204.33 13.42 74 141432 1055 90485886
Peripheral sensory neuropathy 201.65 13.42 144 141362 9106 90477835
Lymphadenopathy 199.13 13.42 298 141208 45477 90441464
Dizziness 198.95 13.42 387 141119 588897 89898044
Agranulocytosis 198.76 13.42 259 141247 34743 90452198
Cardiac dysfunction 196.48 13.42 101 141405 3496 90483445
Post transplant lymphoproliferative disorder 196.32 13.42 127 141379 6822 90480119
Haemophagocytic lymphohistiocytosis 195.90 13.42 175 141331 15284 90471657
Hepatitis B 193.75 13.42 108 141398 4411 90482530
Joint range of motion decreased 192.07 13.42 4 141502 135639 90351302
Muscle spasms 189.45 13.42 78 141428 251805 90235136
Metastases to central nervous system 182.62 13.42 178 141328 17364 90469577
Neoplasm recurrence 182.34 13.42 93 141413 3166 90483775
Injection site pain 182.13 13.42 27 141479 173672 90313269
Bursitis 182.12 13.42 5 141501 131649 90355292
Breast cancer recurrent 181.64 13.42 111 141395 5392 90481549
Blister 179.17 13.42 87 141419 254911 90232030
Immune-mediated myocarditis 178.59 13.42 70 141436 1255 90485686
Pain in extremity 174.61 13.42 271 141235 450258 90036683
Sleep disorder 173.90 13.42 47 141459 197983 90288958
Troponin increased 169.59 13.42 151 141355 13130 90473811
B-cell lymphoma recurrent 168.89 13.42 53 141453 471 90486470
Progressive multifocal leukoencephalopathy 167.00 13.42 161 141345 15494 90471447
Depression 165.28 13.42 136 141370 300465 90186476
Hypersensitivity 164.54 13.42 286 141220 454391 90032550
Anxiety 164.40 13.42 145 141361 309627 90177314
Bacteraemia 162.24 13.42 187 141319 22113 90464828
Malaise 161.10 13.42 430 141076 585556 89901385
Arthritis 158.10 13.42 34 141472 167281 90319660
Dry mouth 151.91 13.42 49 141457 184010 90302931
Anti-Muellerian hormone level decreased 149.42 13.42 35 141471 81 90486860
Myocarditis 143.54 13.42 140 141366 13666 90473275
Systemic candida 143.47 13.42 92 141414 4867 90482074
Metastasis 139.47 13.42 98 141408 6039 90480902
Memory impairment 137.46 13.42 68 141438 197176 90289765
Hypoaesthesia 136.59 13.42 174 141332 314036 90172905
Myeloid leukaemia 136.58 13.42 45 141461 474 90486467
Small intestinal obstruction 136.23 13.42 167 141339 21067 90465874
Road traffic accident 135.78 13.42 8 141498 107618 90379323
Overdose 135.53 13.42 39 141467 157670 90329271
Alopecia 135.46 13.42 364 141142 494707 89992234
Epstein-Barr virus infection 134.85 13.42 119 141387 10225 90476716
Sciatica 132.74 13.42 6 141500 101376 90385565
Lymphopenia 132.54 13.42 171 141335 22710 90464231
Migraine 132.13 13.42 66 141440 190326 90296615
Aplasia 130.44 13.42 80 141426 3911 90483030
Acute lymphocytic leukaemia recurrent 130.40 13.42 70 141436 2651 90484290
Abdominal pain upper 129.87 13.42 199 141307 332475 90154466
Musculoskeletal pain 127.17 13.42 54 141452 171197 90315744
Computerised tomogram thorax abnormal 126.87 13.42 63 141443 2024 90484917
Inflammation 126.84 13.42 60 141446 178532 90308409
Blood pressure increased 125.79 13.42 76 141430 197141 90289800
Lymphoma 125.09 13.42 129 141377 13462 90473479
Bronchopulmonary aspergillosis 124.95 13.42 119 141387 11279 90475662
Confusional state 124.71 13.42 260 141246 385945 90100996
Gait disturbance 124.22 13.42 134 141372 260362 90226579
Feeling abnormal 123.75 13.42 53 141453 167182 90319759
C-reactive protein abnormal 122.22 13.42 25 141481 127404 90359537
Premature delivery 121.97 13.42 218 141288 38544 90448397
Hypercholesterolaemia 120.04 13.42 10 141496 100882 90386059
Diffuse large B-cell lymphoma 119.84 13.42 103 141403 8542 90478399
Metastases to skin 119.53 13.42 61 141445 2079 90484862
Gait inability 119.06 13.42 40 141466 146416 90340525
Neutrophil count abnormal 115.52 13.42 75 141431 4053 90482888
Wound infection 115.14 13.42 15 141491 106387 90380554
Premature menopause 114.38 13.42 51 141455 1278 90485663
Breast cancer stage III 113.93 13.42 4 141502 84443 90402498
Cystitis haemorrhagic 113.72 13.42 83 141423 5430 90481511
Metastases to peritoneum 112.63 13.42 74 141432 4081 90482860
Intentional product misuse 112.00 13.42 7 141499 89597 90397344
Gene mutation 111.14 13.42 58 141448 2072 90484869
Neutropenic infection 111.13 13.42 55 141451 1754 90485187
Loss of personal independence in daily activities 110.94 13.42 37 141469 136068 90350873
Grip strength decreased 110.62 13.42 9 141497 92567 90394374
Treatment failure 109.10 13.42 192 141314 303736 90183205
Drug resistance 108.58 13.42 181 141325 30268 90456673
Peripheral venous disease 106.59 13.42 6 141500 83915 90403026
Hospitalisation 105.86 13.42 34 141472 128066 90358875
Hypogammaglobulinaemia 104.95 13.42 105 141401 10569 90476372
Intestinal perforation 101.98 13.42 117 141389 13764 90473177
Joint stiffness 100.94 13.42 5 141501 78037 90408904
Ventricular hypokinesia 100.30 13.42 76 141430 5265 90481676
Escherichia bacteraemia 99.81 13.42 78 141428 5657 90481284
Thrombotic microangiopathy 99.67 13.42 123 141383 15620 90471321
Prescribed underdose 99.67 13.42 4 141502 75015 90411926
Liver injury 98.97 13.42 73 141433 170494 90316447
Injection site erythema 97.25 13.42 18 141488 98484 90388457
Venoocclusive liver disease 96.78 13.42 78 141428 5915 90481026
Amnesia 96.66 13.42 25 141481 108480 90378461
Ileus 96.37 13.42 124 141382 16422 90470519
Bronchitis 96.02 13.42 60 141446 152867 90334074
Pericardial effusion 95.83 13.42 191 141315 36642 90450299
Pneumatosis intestinalis 95.09 13.42 62 141444 3375 90483566
Mantle cell lymphoma recurrent 93.97 13.42 32 141474 376 90486565
Enterococcal bacteraemia 93.91 13.42 51 141455 1977 90484964
Skin toxicity 92.41 13.42 80 141426 6699 90480242
Encephalopathy 92.35 13.42 216 141290 46228 90440713
Organising pneumonia 92.31 13.42 84 141422 7513 90479428
Condition aggravated 92.09 13.42 549 140957 594996 89891945
Smooth muscle cell neoplasm 91.10 13.42 44 141462 1329 90485612
Injection site reaction 90.53 13.42 17 141489 92063 90394878
Gastrooesophageal reflux disease 90.44 13.42 76 141430 166261 90320680
Computerised tomogram thorax 89.77 13.42 33 141473 492 90486449
Oedema 89.00 13.42 109 141397 200186 90286755
Klebsiella infection 88.09 13.42 94 141412 10203 90476738
Pseudomonal sepsis 87.00 13.42 64 141442 4238 90482703
Hypokalaemia 86.70 13.42 420 141086 130696 90356245
Drug abuse 85.83 13.42 13 141493 82334 90404607
Gastrointestinal toxicity 85.58 13.42 89 141417 9378 90477563
Troponin I increased 85.51 13.42 52 141454 2503 90484438
Adverse drug reaction 83.16 13.42 39 141467 116662 90370279
Hepatitis E 83.09 13.42 46 141460 1853 90485088
Metastases to breast 83.00 13.42 29 141477 370 90486571
Leukaemia 82.80 13.42 66 141440 4926 90482015
Clostridium difficile colitis 82.49 13.42 149 141357 26557 90460384
Visual impairment 81.63 13.42 53 141453 132312 90354629
Product quality issue 81.60 13.42 13 141493 79312 90407629
Hypoxia 80.84 13.42 273 141233 72126 90414815
Administration site extravasation 80.35 13.42 39 141467 1191 90485750
Autoimmune disorder 80.25 13.42 12 141494 76732 90410209
Pulmonary embolism 80.08 13.42 410 141096 130410 90356531
Aspergillus infection 79.13 13.42 91 141415 10732 90476209
Atelectasis 79.01 13.42 139 141367 24270 90462671
Pulmonary toxicity 77.73 13.42 93 141413 11438 90475503
Night sweats 77.47 13.42 53 141453 128713 90358228
Lymphoma transformation 77.42 13.42 24 141482 204 90486737
Varicella zoster virus infection 76.88 13.42 57 141449 3820 90483121
Injection site swelling 76.86 13.42 4 141502 59835 90427106
Enterococcal infection 76.43 13.42 86 141420 9905 90477036
Red blood cell sedimentation rate increased 75.56 13.42 18 141488 82577 90404364
Acute lymphocytic leukaemia 75.45 13.42 50 141456 2798 90484143
Cardiomyopathy acute 75.23 13.42 25 141481 271 90486670
Hepatotoxicity 75.10 13.42 198 141308 45644 90441297
Somnolence 75.07 13.42 132 141374 208952 90277989
Cardiogenic shock 74.92 13.42 136 141370 24332 90462609
Osteolysis 74.48 13.42 54 141452 3496 90483445
Central nervous system lymphoma 74.22 13.42 44 141462 2021 90484920
Acute hepatic failure 73.70 13.42 129 141377 22432 90464509
Fluid retention 73.46 13.42 23 141483 88068 90398873
Vasogenic cerebral oedema 72.71 13.42 37 141469 1253 90485688
Refractory anaemia with an excess of blasts 72.63 13.42 27 141479 416 90486525
Pneumocystis jirovecii infection 71.55 13.42 42 141464 1894 90485047
Toxic cardiomyopathy 71.55 13.42 25 141481 319 90486622
Embolism 71.49 13.42 81 141425 9400 90477541
Myelopathy 71.38 13.42 52 141454 3392 90483549
Chemotherapy 71.14 13.42 41 141465 1786 90485155
Ill-defined disorder 70.75 13.42 112 141394 184779 90302162
Osteoporosis 70.75 13.42 31 141475 96500 90390441
Ear infection 70.51 13.42 12 141494 69763 90417178
Fatigue 70.36 13.42 1325 140181 1152698 89334243
COVID-19 pneumonia 70.16 13.42 112 141394 18065 90468876
Premature baby 70.05 13.42 134 141372 24943 90461998
Neck pain 69.77 13.42 46 141460 113917 90373024
Hypertriglyceridaemia 69.23 13.42 73 141433 7816 90479125
Injection site pruritus 67.90 13.42 4 141502 53830 90433111
JC virus infection 67.86 13.42 46 141460 2673 90484268
Cytomegalovirus chorioretinitis 67.81 13.42 44 141462 2375 90484566
Infusion related reaction 67.67 13.42 378 141128 416402 90070539
Metastases to spine 67.51 13.42 52 141454 3691 90483250
Oligohydramnios 67.44 13.42 69 141437 7132 90479809
Cardiac failure acute 67.29 13.42 88 141418 11841 90475100
Illness 67.29 13.42 22 141484 81947 90404994
Immune effector cell-associated neurotoxicity syndrome 66.63 13.42 62 141444 5706 90481235
Gastrosplenic fistula 66.44 13.42 17 141489 64 90486877
Candida infection 66.19 13.42 157 141349 33900 90453041
T-cell type acute leukaemia 64.89 13.42 19 141487 130 90486811
Systolic dysfunction 64.37 13.42 39 141467 1865 90485076
Metastases to pleura 64.33 13.42 40 141466 2004 90484937
Obesity 64.03 13.42 43 141463 105464 90381477
Colitis ulcerative 64 13.42 9 141497 60257 90426684
Cardiac failure chronic 63.89 13.42 60 141446 5586 90481355
Dyspepsia 63.38 13.42 134 141372 198026 90288915
White blood cell count abnormal 63.31 13.42 68 141438 7436 90479505
Peripheral motor neuropathy 63.08 13.42 39 141467 1934 90485007
Ovarian cancer recurrent 62.76 13.42 36 141470 1554 90485387
Nasal congestion 62.39 13.42 26 141480 83388 90403553
Suicide attempt 62.31 13.42 20 141486 75379 90411562
Adverse event 62.17 13.42 55 141451 117363 90369578
Cataract 61.60 13.42 18 141488 72074 90414867
Chest pain 61.57 13.42 273 141233 319372 90167569
Acquired gene mutation 61.56 13.42 33 141473 1246 90485695
Fanconi syndrome 61.09 13.42 38 141468 1905 90485036
Follicular lymphoma 61.02 13.42 23 141483 369 90486572
Cytomegalovirus viraemia 60.95 13.42 67 141439 7519 90479422
Acute pulmonary oedema 60.89 13.42 75 141431 9505 90477436
Hepatic failure 60.46 13.42 167 141339 39561 90447380
Recurrent cancer 59.94 13.42 41 141465 2418 90484523
Stress 59.87 13.42 26 141480 81369 90405572
Diastolic dysfunction 59.33 13.42 65 141441 7268 90479673
Bone lesion 59.06 13.42 61 141445 6376 90480565
Left ventricular failure 58.80 13.42 62 141444 6638 90480303
Lymphadenitis 58.79 13.42 50 141456 4087 90482854
Muscular weakness 58.66 13.42 149 141357 206517 90280424
Infection reactivation 58.63 13.42 37 141469 1903 90485038
Live birth 58.61 13.42 25 141481 79082 90407859
Inappropriate schedule of product administration 58.14 13.42 90 141416 149843 90337098
Pneumonia fungal 58.06 13.42 63 141443 6968 90479973
Capillary leak syndrome 57.85 13.42 42 141464 2725 90484216
Haemoglobin abnormal 57.56 13.42 63 141443 7037 90479904
Injection site bruising 57.49 13.42 7 141499 52300 90434641
Hypoalbuminaemia 57.35 13.42 95 141411 15802 90471139
Nephropathy toxic 57.17 13.42 84 141422 12604 90474337
Heart rate decreased 56.80 13.42 8 141498 53497 90433444
Intentional product use issue 55.84 13.42 164 141342 216728 90270213
Clostridium difficile infection 55.79 13.42 153 141353 36092 90450849
Ileus paralytic 55.56 13.42 53 141453 5032 90481909
Venoocclusive disease 55.31 13.42 39 141467 2416 90484525
Salivary gland cancer 55.20 13.42 18 141488 183 90486758
Frequent bowel movements 54.93 13.42 11 141495 56924 90430017
Medication error 54.82 13.42 32 141474 84620 90402321
Abdominal compartment syndrome 54.71 13.42 26 141480 757 90486184
Alveolitis 54.56 13.42 42 141464 2979 90483962
Pleuroparenchymal fibroelastosis 54.43 13.42 18 141488 192 90486749
Therapy interrupted 54.36 13.42 7 141499 50101 90436840
Invasive ductal breast carcinoma 54.26 13.42 64 141442 7754 90479187
Joint dislocation 54.20 13.42 4 141502 44578 90442363
Pulmonary alveolar haemorrhage 53.52 13.42 56 141450 5942 90480999
Mucosal toxicity 53.34 13.42 21 141485 381 90486560
Ototoxicity 53.29 13.42 35 141471 1929 90485012
Lymphocyte count decreased 53.01 13.42 147 141359 34903 90452038
Mitral valve incompetence 52.92 13.42 112 141394 22412 90464529
Laryngitis 52.92 13.42 8 141498 50745 90436196
Perineal necrosis 52.69 13.42 16 141490 126 90486815
Deep vein thrombosis 52.51 13.42 282 141224 91338 90395603
Brain oedema 52.43 13.42 96 141410 17289 90469652
Incorrect dose administered 52.31 13.42 29 141477 78901 90408040
Suicidal ideation 52.13 13.42 25 141481 73830 90413111
Nail pigmentation 51.71 13.42 18 141488 227 90486714
Perineal infection 51.69 13.42 17 141489 178 90486763
Acute hepatitis B 51.52 13.42 20 141486 349 90486592
Gastrointestinal fungal infection 51.42 13.42 21 141485 421 90486520
Leukoerythroblastosis 51.22 13.42 19 141487 291 90486650
Hyperferritinaemia 51.00 13.42 20 141486 359 90486582
Geotrichum infection 50.98 13.42 23 141483 593 90486348
Extravasation 50.90 13.42 40 141466 2924 90484017
Maternal exposure during pregnancy 50.88 13.42 341 141165 359722 90127219
Balance disorder 50.77 13.42 46 141460 97034 90389907
Nephrolithiasis 50.58 13.42 8 141498 49077 90437864
Device related infection 50.25 13.42 119 141387 25667 90461274
Paronychia 49.79 13.42 62 141444 7944 90478997
Enterococcal sepsis 49.29 13.42 31 141475 1585 90485356
5q minus syndrome 48.86 13.42 17 141489 214 90486727
Colony stimulating factor therapy 48.83 13.42 20 141486 404 90486537
COVID-19 48.61 13.42 439 141067 168404 90318537
Granulocytopenia 48.51 13.42 55 141451 6386 90480555
Heart rate abnormal 48.43 13.42 53 141453 5918 90481023
Pyomyositis 48.42 13.42 20 141486 413 90486528
Malignant transformation 48.31 13.42 22 141484 580 90486361
Dysplasia 48.28 13.42 29 141477 1365 90485576
Death 48.27 13.42 990 140516 455561 90031380
Disseminated intravascular coagulation 48.20 13.42 105 141401 21433 90465508
Pseudocellulitis 48.13 13.42 15 141491 130 90486811
Paraesthesia 46.86 13.42 216 141290 250110 90236831
Troponin T increased 46.68 13.42 30 141476 1593 90485348
Enterocolitis 46.62 13.42 69 141437 10421 90476520
Staphylococcal sepsis 46.50 13.42 65 141441 9318 90477623
Cutaneous calcification 46.46 13.42 16 141490 195 90486746
Taste disorder 46.32 13.42 19 141487 61527 90425414
Onychomadesis 46.28 13.42 8 141498 45990 90440951
Tumour marker increased 46.16 13.42 51 141455 5756 90481185
Cardiac ventricular thrombosis 45.63 13.42 26 141480 1108 90485833
Hepatic infarction 45.56 13.42 22 141484 664 90486277
Pregnancy 45.35 13.42 20 141486 62027 90424914
Hydrothorax 45.14 13.42 25 141481 1008 90485933
Epstein-Barr virus associated lymphoma 44.90 13.42 22 141484 686 90486255
Colitis 44.75 13.42 222 141284 69720 90417221
Premature labour 44.36 13.42 77 141429 13299 90473642
Plasmacytoma 44.35 13.42 36 141470 2757 90484184
Angioedema 44.22 13.42 23 141483 64853 90422088
Hypertension 44.12 13.42 479 141027 457053 90029888
Swollen tongue 44.09 13.42 9 141497 45947 90440994
Acute respiratory distress syndrome 44.06 13.42 121 141385 28565 90458376
Blood pressure systolic increased 43.93 13.42 18 141488 58327 90428614
Alveolar soft part sarcoma 43.77 13.42 13 141493 94 90486847
Bacterial sepsis 43.75 13.42 46 141460 4909 90482032
Hip arthroplasty 43.69 13.42 33 141473 76175 90410766
Foetal growth restriction 43.57 13.42 63 141443 9317 90477624
Amenorrhoea 43.56 13.42 71 141435 11651 90475290
Liver function test increased 43.43 13.42 41 141465 84814 90402127
Cerebrovascular accident 43.41 13.42 79 141427 123454 90363487
Myeloproliferative neoplasm 43.28 13.42 21 141485 641 90486300
Blood pressure fluctuation 43.13 13.42 14 141492 52399 90434542
Humoral immune defect 43.13 13.42 18 141488 382 90486559
Unintentional medical device removal 43.02 13.42 54 141452 6976 90479965
Rash pruritic 42.93 13.42 39 141467 82175 90404766
Philadelphia chromosome positive 42.80 13.42 19 141487 471 90486470
Bicytopenia 42.53 13.42 40 141466 3731 90483210
B-cell aplasia 42.49 13.42 16 141490 256 90486685
Plasma cell leukaemia 42.48 13.42 25 141481 1133 90485808
Pneumothorax 42.39 13.42 93 141413 19074 90467867
Acute monocytic leukaemia 42.28 13.42 14 141492 150 90486791
Strongyloidiasis 42.13 13.42 28 141478 1574 90485367
Malnutrition 42.13 13.42 91 141415 18467 90468474
Peripartum cardiomyopathy 42.13 13.42 15 141491 203 90486738
Blood disorder 41.68 13.42 56 141450 7734 90479207
Pseudocirrhosis 41.67 13.42 23 141483 921 90486020
Cytomegalovirus infection 41.65 13.42 113 141393 26489 90460452
Metastases to bone marrow 41.56 13.42 20 141486 599 90486342
Nail bed inflammation 41.48 13.42 29 141477 1772 90485169
Hepatocellular injury 41.39 13.42 119 141387 28839 90458102
Immune-mediated adrenal insuficiency 41.38 13.42 24 141482 1058 90485883
Synovial sarcoma 40.99 13.42 11 141495 52 90486889
Metastases to meninges 40.95 13.42 39 141467 3696 90483245
Blast cells present 40.63 13.42 19 141487 533 90486408
Clonal evolution 40.38 13.42 12 141494 87 90486854
Onycholysis 40.26 13.42 31 141475 2199 90484742
Vision blurred 40.14 13.42 69 141437 110224 90376717
Hypertransaminasaemia 39.89 13.42 81 141425 15744 90471197
Ovarian epithelial cancer recurrent 39.65 13.42 9 141497 17 90486924
Venous thrombosis 39.55 13.42 46 141460 5491 90481450
Primary cardiac lymphoma 39.32 13.42 9 141497 18 90486923
Nail disorder 38.71 13.42 22 141484 59045 90427896
Chemotherapeutic drug level increased 38.50 13.42 14 141492 202 90486739
Rhinovirus infection 38.41 13.42 47 141459 5916 90481025
Ovarian cancer metastatic 38.38 13.42 23 141483 1078 90485863
Mucormycosis 38.33 13.42 38 141468 3783 90483158
Hyperpyrexia 38.17 13.42 42 141464 4719 90482222
Hepatic cirrhosis 38.08 13.42 26 141480 63227 90423714
Dry eye 37.37 13.42 22 141484 57909 90429032
Leukoencephalopathy 37.37 13.42 42 141464 4831 90482110
Flagellate dermatitis 37.34 13.42 13 141493 164 90486777
Endometrial adenocarcinoma 37.31 13.42 25 141481 1425 90485516
Atrial fibrillation 37.23 13.42 345 141161 133266 90353675
Cytomegalovirus infection reactivation 37.13 13.42 53 141453 7747 90479194
Lung infiltration 37.08 13.42 77 141429 15205 90471736
Dry skin 36.96 13.42 50 141456 88023 90398918
Traumatic lung injury 36.95 13.42 27 141479 1769 90485172
Stenotrophomonas bacteraemia 36.89 13.42 12 141494 121 90486820
Sinus tachycardia 36.79 13.42 113 141393 28400 90458541
Pulmonary fibrosis 36.67 13.42 70 141436 107433 90379508
Proteinuria 36.53 13.42 99 141407 23192 90463749
Onychomycosis 36.52 13.42 7 141499 37369 90449572
Clostridium bacteraemia 36.29 13.42 14 141492 240 90486701
Mesenteric abscess 36.29 13.42 11 141495 86 90486855
Klebsiella bacteraemia 36.17 13.42 31 141475 2561 90484380
Loss of consciousness 36.11 13.42 106 141400 140132 90346809
Peripheral sensorimotor neuropathy 35.99 13.42 28 141478 2017 90484924
Quadriplegia 35.95 13.42 29 141477 2202 90484739
Hyperhidrosis 35.85 13.42 102 141404 136203 90350738
Tremor 35.77 13.42 121 141385 153052 90333889
Drug clearance decreased 35.62 13.42 27 141479 1871 90485070
Squamous cell carcinoma of the oral cavity 35.55 13.42 16 141490 410 90486531
Pneumonia 35.33 13.42 1272 140234 636787 89850154
Atypical haemolytic uraemic syndrome 35.32 13.42 21 141485 970 90485971
Small intestinal perforation 35.23 13.42 27 141479 1902 90485039
Blood glucose increased 35.20 13.42 59 141447 95187 90391754
Eastern Cooperative Oncology Group performance status worsened 35.11 13.42 27 141479 1912 90485029
Mass 34.92 13.42 76 141430 15501 90471440
Metastases to the mediastinum 34.59 13.42 18 141488 639 90486302
Invasive lobular breast carcinoma 34.59 13.42 21 141485 1008 90485933
Mucoepidermoid carcinoma of salivary gland 34.55 13.42 9 141497 37 90486904
Necrotising gastritis 34.46 13.42 10 141496 66 90486875
Peripheral T-cell lymphoma unspecified 34.45 13.42 14 141492 277 90486664
Acute myelomonocytic leukaemia 34.35 13.42 13 141493 211 90486730
Platelet count abnormal 34.33 13.42 38 141468 4297 90482644
Respiratory syncytial virus infection 34.33 13.42 60 141446 10420 90476521
Hypoglycaemia 34.30 13.42 35 141471 69813 90417128
Carbohydrate antigen 15-3 increased 34.28 13.42 27 141479 1980 90484961
Necrotising colitis 34.26 13.42 23 141483 1315 90485626
Rhinorrhoea 34.24 13.42 53 141453 88263 90398678
Large intestinal ulcer perforation 34.20 13.42 10 141496 68 90486873
Radiation necrosis 34.19 13.42 18 141488 655 90486286
Nasal mucosal disorder 33.93 13.42 26 141480 1831 90485110
Thrombocytopenic purpura 33.88 13.42 26 141480 1835 90485106
Vocal cord paralysis 33.78 13.42 29 141477 2401 90484540
Carbohydrate antigen 125 increased 33.73 13.42 33 141473 3233 90483708
Ovarian cancer 33.72 13.42 47 141459 6720 90480221
Rectal haemorrhage 33.69 13.42 48 141458 82696 90404245
Splenomegaly 33.59 13.42 67 141439 12857 90474084
Surgery 33.55 13.42 14 141492 44873 90442068
Localised infection 33.41 13.42 6 141500 33556 90453385
Swelling face 33.32 13.42 47 141459 81305 90405636
Streptococcal sepsis 32.95 13.42 34 141472 3550 90483391
Body dysmorphic disorder 32.92 13.42 15 141491 396 90486545
Secondary immunodeficiency 32.91 13.42 27 141479 2099 90484842
Osteomyelitis bacterial 32.91 13.42 13 141493 238 90486703
Tracheo-oesophageal fistula 32.91 13.42 18 141488 708 90486233
Oophoritis 32.88 13.42 12 141494 175 90486766
Treatment noncompliance 32.86 13.42 20 141486 51707 90435234
Nasal abscess 32.64 13.42 12 141494 179 90486762
Stem cell transplant 32.60 13.42 27 141479 2127 90484814
Tumour necrosis 32.55 13.42 20 141486 981 90485960
Tissue infiltration 32.48 13.42 19 141487 851 90486090
Dermatitis bullous 32.42 13.42 58 141448 10258 90476683
Hyperbilirubinaemia 32.40 13.42 69 141437 13867 90473074
Walking aid user 31.96 13.42 8 141498 35498 90451443
Hepatitis B core antibody positive 31.92 13.42 14 141492 337 90486604
Neurological symptom 31.82 13.42 46 141460 6801 90480140
Ear pain 31.80 13.42 26 141480 57676 90429265
Acute leukaemia 31.69 13.42 21 141485 1175 90485766
Limb discomfort 31.61 13.42 10 141496 38050 90448891
Heart rate increased 31.55 13.42 82 141424 112820 90374121
T-cell lymphoma 31.32 13.42 18 141488 780 90486161
Hepatic function abnormal 31.09 13.42 149 141357 46139 90440802
Intertrigo 30.86 13.42 18 141488 802 90486139
Soft tissue neoplasm 30.82 13.42 10 141496 100 90486841
Left atrial enlargement 30.68 13.42 17 141489 686 90486255
Haemorrhage intracranial 30.66 13.42 71 141435 15091 90471850
Sinus disorder 30.55 13.42 8 141498 34439 90452502
Sneezing 30.48 13.42 5 141501 29864 90457077
Bone marrow infiltration 30.42 13.42 18 141488 824 90486117
Toxic erythema of chemotherapy 30.27 13.42 12 141494 222 90486719
Liver disorder 30.26 13.42 93 141413 121176 90365765
Metastatic lymphoma 30.17 13.42 12 141494 224 90486717
Amniotic fluid index decreased 30.13 13.42 8 141498 36 90486905
Necrosis 30.13 13.42 44 141462 6566 90480375
Eye irritation 29.93 13.42 8 141498 33970 90452971
Graft versus host disease 29.82 13.42 49 141457 8095 90478846
Eye pain 29.60 13.42 16 141490 44152 90442789
Retroperitoneal lymphadenopathy 29.44 13.42 17 141489 743 90486198
Soft tissue infection 29.41 13.42 29 141477 2868 90484073
Immune-mediated hypophysitis 29.37 13.42 15 141491 512 90486429
Respiratory tract congestion 29.32 13.42 4 141502 27406 90459535
Back disorder 29.25 13.42 3 141503 25628 90461313
Hallucination 29.16 13.42 36 141470 65923 90421018
Feeling hot 29.12 13.42 48 141458 77960 90408981
Anaplastic large cell lymphoma T- and null-cell types recurrent 29.09 13.42 7 141499 19 90486922
Paraparesis 29.07 13.42 29 141477 2909 90484032
Myasthenia gravis crisis 28.96 13.42 19 141487 1045 90485896
Tachypnoea 28.95 13.42 86 141420 21223 90465718
Aplastic anaemia 28.91 13.42 64 141442 13205 90473736
Subclavian vein thrombosis 28.90 13.42 25 141481 2091 90484850
Toxic neuropathy 28.82 13.42 15 141491 533 90486408
Influenza like illness 28.81 13.42 51 141455 80560 90406381
Left ventricular dilatation 28.80 13.42 16 141490 649 90486292
Inappropriate antidiuretic hormone secretion 28.70 13.42 81 141425 19424 90467517
Radiotherapy 28.68 13.42 18 141488 917 90486024
Pulse waveform abnormal 28.68 13.42 9 141497 80 90486861
Invasive breast carcinoma 28.61 13.42 18 141488 921 90486020
Acne 28.59 13.42 5 141501 28502 90458439
Gastrointestinal necrosis 28.58 13.42 30 141476 3195 90483746
Ankle brachial index decreased 28.58 13.42 9 141497 81 90486860
Leukaemic lymphoma 28.58 13.42 9 141497 81 90486860
Cytogenetic abnormality 28.56 13.42 15 141491 543 90486398
Large intestine perforation 28.49 13.42 53 141453 9659 90477282
Osteonecrosis 28.45 13.42 98 141408 26143 90460798
Adrenal insufficiency 28.40 13.42 107 141399 29814 90457127
Pericardial effusion malignant 28.39 13.42 11 141495 191 90486750
Constipation 28.27 13.42 604 140902 279791 90207150
Intestinal obstruction 28.26 13.42 124 141382 37007 90449934
Adverse reaction 28.13 13.42 6 141500 29706 90457235
Lymphoproliferative disorder 28.11 13.42 34 141472 4228 90482713
Primary immunodeficiency syndrome 28.08 13.42 8 141498 49 90486892
Cerebellar haemangioma 27.91 13.42 9 141497 88 90486853
Renal failure 27.80 13.42 320 141186 130687 90356254
Eye swelling 27.68 13.42 6 141500 29380 90457561
Therapeutic response delayed 27.68 13.42 17 141489 833 90486108
Hepatic lesion 27.67 13.42 39 141467 5634 90481307
Arrhythmia 27.53 13.42 135 141371 42197 90444744
Leukaemia cutis 27.52 13.42 10 141496 144 90486797
Primary mediastinal large B-cell lymphoma recurrent 27.47 13.42 9 141497 93 90486848
Thyroid dermatopathy 27.43 13.42 7 141499 26 90486915
Klebsiella test positive 27.37 13.42 21 141485 1482 90485459
Febrile infection 27.36 13.42 24 141482 2045 90484896
Lip swelling 27.35 13.42 13 141493 38597 90448344
Gastric disorder 27.32 13.42 9 141497 33375 90453566
Thyroiditis 27.30 13.42 31 141475 3606 90483335
Pseudomonas infection 27.24 13.42 67 141439 14798 90472143
Hydronephrosis 27.23 13.42 60 141446 12342 90474599
Carotid intima-media thickness increased 27.13 13.42 9 141497 97 90486844
Device pacing issue 26.88 13.42 9 141497 100 90486841
Drug interaction 26.78 13.42 289 141217 276164 90210777
Vena cava thrombosis 26.75 13.42 26 141480 2526 90484415
Ventricular internal diameter abnormal 26.64 13.42 7 141499 30 90486911
Underdose 26.60 13.42 27 141479 53990 90432951
Food allergy 26.60 13.42 4 141502 25474 90461467
Peritoneal disorder 26.52 13.42 15 141491 630 90486311
Acute erythroid leukaemia 26.50 13.42 10 141496 161 90486780
Periorbital cellulitis 26.48 13.42 16 141490 761 90486180
Hypomagnesaemia 26.45 13.42 118 141388 35470 90451471
Muscle spasticity 26.42 13.42 11 141495 35311 90451630
Cerebellar stroke 26.37 13.42 13 141493 411 90486530
Unevaluable event 26.35 13.42 28 141478 54820 90432121
Klebsiella sepsis 26.29 13.42 22 141484 1759 90485182
Abdominal abscess 26.22 13.42 37 141469 5350 90481591
Orthopnoea 26.22 13.42 42 141464 6793 90480148
Cardiac imaging procedure abnormal 26.21 13.42 6 141500 12 90486929
Radiation skin injury 26.01 13.42 18 141488 1082 90485859
Metastases to pancreas 25.98 13.42 12 141494 327 90486614
Pneumonia bacterial 25.98 13.42 60 141446 12730 90474211
Rhabdomyolysis 25.95 13.42 25 141481 51231 90435710
Aeromonas infection 25.95 13.42 10 141496 171 90486770
Adenovirus infection 25.92 13.42 34 141472 4588 90482353
Chronic myeloid leukaemia 25.81 13.42 26 141480 2638 90484303
Drug dependence 25.65 13.42 7 141499 29320 90457621
B-cell lymphoma 25.56 13.42 30 141476 3616 90483325
Lymphadenopathy mediastinal 25.49 13.42 28 141478 3139 90483802
Laboratory test abnormal 25.47 13.42 17 141489 41837 90445104
Seasonal allergy 25.44 13.42 3 141503 22980 90463961
Hyperglycaemia 25.31 13.42 151 141355 50819 90436122
B-cell lymphoma refractory 25.30 13.42 8 141498 73 90486868
Therapeutic response shortened 25.30 13.42 3 141503 22876 90464065
Acute respiratory failure 25.20 13.42 133 141373 42785 90444156
Tumour haemorrhage 25.14 13.42 23 141483 2071 90484870
Mastectomy 25.09 13.42 23 141483 2076 90484865
Infusion site streaking 25.08 13.42 14 141492 573 90486368
Sinus congestion 25.03 13.42 6 141500 27418 90459523
Lymphocytosis 25.00 13.42 27 141479 2970 90483971
Palpitations 24.97 13.42 119 141387 136609 90350332
Weight decreased 24.94 13.42 430 141076 379480 90107461
Product prescribing error 24.90 13.42 8 141498 30137 90456804
Oedema peripheral 24.83 13.42 270 141236 257645 90229296
Injection site rash 24.77 13.42 4 141502 24169 90462772
Cachexia 24.67 13.42 41 141465 6837 90480104
Basal ganglion degeneration 24.62 13.42 12 141494 370 90486571
Light chain analysis increased 24.52 13.42 20 141486 1542 90485399
Cerebral venous sinus thrombosis 24.52 13.42 24 141482 2352 90484589
Vaccination failure 24.43 13.42 18 141488 1195 90485746
Chronic obstructive pulmonary disease 24.37 13.42 49 141457 73780 90413161
Abdominal neoplasm 24.35 13.42 12 141494 379 90486562
Dementia 24.33 13.42 4 141502 23857 90463084
Accidental overdose 24.26 13.42 7 141499 28266 90458675
Lung disorder 24.24 13.42 136 141370 149747 90337194
Pneumonia cytomegaloviral 24.17 13.42 27 141479 3084 90483857
Duodenal stenosis 24.16 13.42 14 141492 616 90486325
Chronic hepatitis B 24.15 13.42 12 141494 386 90486555
Mucoepidermoid carcinoma 24.15 13.42 7 141499 46 90486895
Metastases to soft tissue 24.08 13.42 11 141495 292 90486649
Epstein-Barr virus associated lymphoproliferative disorder 23.97 13.42 25 141481 2642 90484299
Diarrhoea haemorrhagic 23.88 13.42 52 141454 10611 90476330
Hormone receptor positive breast cancer 23.87 13.42 15 141491 766 90486175
Lung adenocarcinoma 23.86 13.42 36 141470 5529 90481412
Device electrical impedance issue 23.86 13.42 5 141501 5 90486936
Blood stem cell transplant failure 23.84 13.42 10 141496 215 90486726
Combined immunodeficiency 23.73 13.42 9 141497 147 90486794
Toxic encephalopathy 23.70 13.42 46 141460 8653 90478288
Multiple sclerosis 23.69 13.42 7 141499 27833 90459108
Chronic myelomonocytic leukaemia 23.65 13.42 12 141494 404 90486537
Granulomatous liver disease 23.55 13.42 16 141490 933 90486008
Cardiac tamponade 23.54 13.42 36 141470 5596 90481345
Sinus polyp 23.46 13.42 12 141494 411 90486530
Escherichia infection 23.38 13.42 66 141440 15829 90471112
Clonal haematopoiesis 23.37 13.42 6 141500 23 90486918
Metastases to chest wall 23.34 13.42 14 141492 657 90486284
Nervousness 23.32 13.42 12 141494 34044 90452897
Gas gangrene 23.24 13.42 9 141497 156 90486785
Device dislocation 23.24 13.42 10 141496 31472 90455469
Ovarian stromal hyperplasia 23.16 13.42 6 141500 24 90486917
Renal-limited thrombotic microangiopathy 23.10 13.42 10 141496 233 90486708
Respiratory distress 23.08 13.42 121 141385 38825 90448116
Incorrect route of product administration 23.05 13.42 27 141479 50599 90436342
IIIrd nerve paralysis 23.00 13.42 15 141491 817 90486124
Plasma cells increased 22.97 13.42 8 141498 101 90486840
Blood lactate dehydrogenase abnormal 22.86 13.42 12 141494 434 90486507
Intervertebral disc protrusion 22.85 13.42 7 141499 27189 90459752
Device adhesion issue 22.82 13.42 39 141467 6652 90480289
Recall phenomenon 22.72 13.42 15 141491 834 90486107
Upper respiratory tract infection 22.67 13.42 113 141393 128205 90358736
Ectropion 22.63 13.42 10 141496 245 90486696
Electrolyte imbalance 22.61 13.42 85 141421 23660 90463281
Depressed level of consciousness 22.61 13.42 50 141456 72734 90414207
Basal cell carcinoma 22.51 13.42 12 141494 33377 90453564
Acute polyneuropathy 22.49 13.42 12 141494 449 90486492
Hypofibrinogenaemia 22.48 13.42 18 141488 1352 90485589
Hypothyroidism 22.42 13.42 151 141355 52976 90433965
Respiratory arrest 22.42 13.42 12 141494 33299 90453642
Anaesthesia 22.41 13.42 12 141494 452 90486489
Mediastinitis 22.36 13.42 11 141495 346 90486595
Flatulence 22.35 13.42 19 141487 41348 90445593
PIK3CA-activated mutation 22.32 13.42 17 141489 1187 90485754
Glaucoma 22.27 13.42 3 141503 20752 90466189
Central nervous system enteroviral infection 22.25 13.42 6 141500 29 90486912
Oesophageal candidiasis 22.24 13.42 39 141467 6790 90480151
Joint neoplasm 22.23 13.42 7 141499 63 90486878
Increased liver stiffness 22.19 13.42 5 141501 9 90486932
Emotional distress 22.16 13.42 15 141491 36647 90450294
Foot fracture 22.08 13.42 7 141499 26599 90460342
Streptococcal bacteraemia 22.06 13.42 22 141484 2205 90484736
Gastric perforation 22.05 13.42 21 141485 1990 90484951
Plasma cell myeloma recurrent 22.02 13.42 30 141476 4198 90482743
Plasma cell myeloma refractory 22.01 13.42 16 141490 1040 90485901
Heavy menstrual bleeding 21.95 13.42 3 141503 20527 90466414
Amputation stump pain 21.92 13.42 6 141500 31 90486910
Paraesthesia oral 21.91 13.42 11 141495 31648 90455293
Dysstasia 21.87 13.42 6 141500 25046 90461895
Gastroenteritis viral 21.84 13.42 10 141496 30345 90456596
Venous thrombosis limb 21.83 13.42 27 141479 3435 90483506
Subdural hygroma 21.81 13.42 10 141496 268 90486673
Infective aortitis 21.76 13.42 6 141500 32 90486909
B-cell type acute leukaemia 21.75 13.42 13 141493 606 90486335
Liver abscess 21.62 13.42 27 141479 3469 90483472
Gastric stenosis 21.57 13.42 7 141499 70 90486871
Sarcoid-like reaction 21.48 13.42 9 141497 193 90486748
Pulmonary haemorrhage 21.38 13.42 42 141464 7971 90478970
Nightmare 21.37 13.42 4 141502 21721 90465220
Hypocalcaemia 21.35 13.42 126 141380 42242 90444699
Acute kidney injury 21.34 13.42 653 140853 319734 90167207
Odynophagia 21.28 13.42 45 141461 8998 90477943
Fluid replacement 21.26 13.42 13 141493 632 90486309
Fungal oesophagitis 21.26 13.42 14 141492 775 90486166
Encephalitis viral 21.23 13.42 20 141486 1869 90485072
Precursor T-lymphoblastic lymphoma/leukaemia 21.22 13.42 7 141499 74 90486867
Failure to thrive 21.14 13.42 43 141463 8368 90478573
Vulvovaginitis 21.13 13.42 11 141495 391 90486550
Lymphoedema 21.11 13.42 58 141448 13695 90473246
Therapy non-responder 21.08 13.42 315 141191 136389 90350552
Nausea 21.07 13.42 2009 139497 1108307 89378634
Oral fungal infection 21.04 13.42 26 141480 3306 90483635
Refractory cytopenia with multilineage dysplasia 21.02 13.42 8 141498 132 90486809
Acute biphenotypic leukaemia 20.97 13.42 7 141499 77 90486864
Deafness bilateral 20.93 13.42 19 141487 1694 90485247
Tendonitis 20.89 13.42 4 141502 21368 90465573
Malignant ascites 20.88 13.42 15 141491 957 90485984
Heart rate irregular 20.84 13.42 6 141500 24262 90462679
Joint effusion 20.79 13.42 3 141503 19707 90467234
Bacterial infection 20.75 13.42 82 141424 23362 90463579
Subileus 20.74 13.42 27 141479 3617 90483324
Transaminases 20.73 13.42 7 141499 80 90486861
Mediastinum neoplasm 20.65 13.42 7 141499 81 90486860
Hypoproteinaemia 20.62 13.42 25 141481 3117 90483824
Influenza 20.60 13.42 130 141376 139134 90347807
Nodular regenerative hyperplasia 20.58 13.42 13 141493 670 90486271
Blood bilirubin abnormal 20.57 13.42 20 141486 1944 90484997
Therapy cessation 20.52 13.42 16 141490 36345 90450596
Precocious puberty 20.44 13.42 10 141496 311 90486630
Carpal tunnel syndrome 20.39 13.42 6 141500 23922 90463019
Maternal exposure timing unspecified 20.36 13.42 5 141501 22478 90464463
Hepatomegaly 20.26 13.42 56 141450 13270 90473671
Postictal state 20.13 13.42 17 141489 1376 90485565
Panic attack 20.06 13.42 8 141498 26357 90460584
Monoparesis 20.04 13.42 20 141486 2007 90484934
Pleural disorder 20.01 13.42 13 141493 703 90486238
Pulmonary vein stenosis 19.99 13.42 7 141499 90 90486851
Gastrointestinal perforation 19.98 13.42 29 141477 4303 90482638
Lipidosis 19.90 13.42 6 141500 46 90486895
Left ventricular hypertrophy 19.90 13.42 35 141471 6109 90480832
Head injury 19.89 13.42 12 141494 31176 90455765
Cholelithiasis 19.89 13.42 32 141474 52474 90434467
Enterocolitis infectious 19.87 13.42 20 141486 2027 90484914
Infusion site necrosis 19.85 13.42 7 141499 92 90486849
Diabetes mellitus 19.79 13.42 45 141461 64830 90422111
Tooth disorder 19.78 13.42 12 141494 31078 90455863
Dysaesthesia 19.76 13.42 32 141474 5223 90481718
Meningitis 19.72 13.42 42 141464 8439 90478502
Pharyngeal inflammation 19.72 13.42 15 141491 1045 90485896
International normalised ratio increased 19.71 13.42 27 141479 47289 90439652
Listeria sepsis 19.69 13.42 13 141493 723 90486218
Stomatitis 19.68 13.42 565 140941 274133 90212808
Peritonitis viral 19.67 13.42 6 141500 48 90486893
Lymphatic duct injury 19.67 13.42 6 141500 48 90486893
Intussusception 19.66 13.42 15 141491 1050 90485891
Marginal zone lymphoma 19.58 13.42 7 141499 96 90486845
Jugular vein thrombosis 19.55 13.42 26 141480 3555 90483386
Sputum discoloured 19.54 13.42 4 141502 20387 90466554
Kidney infection 19.50 13.42 8 141498 25908 90461033
Neoplasm 19.46 13.42 43 141463 8860 90478081
Pneumonia klebsiella 19.44 13.42 24 141482 3048 90483893
BRCA2 gene mutation 19.38 13.42 7 141499 99 90486842
Opsoclonus myoclonus 19.38 13.42 8 141498 165 90486776
Hip fracture 19.38 13.42 14 141492 33063 90453878
Renal vein thrombosis 19.38 13.42 12 141494 597 90486344
Mitral valve disease 19.37 13.42 22 141484 2560 90484381
Urethritis 19.36 13.42 9 141497 249 90486692
Diabetes mellitus inadequate control 19.35 13.42 3 141503 18681 90468260
Fungaemia 19.34 13.42 25 141481 3325 90483616
Deafness 19.33 13.42 78 141428 22436 90464505
Breast cancer 19.32 13.42 147 141359 53614 90433327
Chromosomal deletion 19.31 13.42 7 141499 100 90486841
Enterovirus infection 19.30 13.42 17 141489 1457 90485484
Adrenocortical insufficiency acute 19.23 13.42 22 141484 2579 90484362
Rash erythematous 19.19 13.42 46 141460 65058 90421883
Pustular psoriasis 19.17 13.42 3 141503 18553 90468388
B precursor type acute leukaemia 19.16 13.42 9 141497 255 90486686
BK virus infection 19.15 13.42 29 141477 4469 90482472
Osteosarcoma metastatic 19.11 13.42 5 141501 21 90486920
Pericardial calcification 19.11 13.42 5 141501 21 90486920
Throat irritation 19.09 13.42 29 141477 48666 90438275
Metastatic neoplasm 19.04 13.42 30 141476 4785 90482156
Joint ankylosis 19.03 13.42 16 141490 1287 90485654
Drug ineffective for unapproved indication 19.02 13.42 173 141333 66471 90420470
Myocardial infarction 18.90 13.42 93 141413 105879 90381062
Blood pressure diastolic abnormal 18.85 13.42 4 141502 19877 90467064
Hypophagia 18.84 13.42 108 141398 35829 90451112
Fasciitis 18.81 13.42 12 141494 629 90486312
Herpes simplex 18.78 13.42 46 141460 10135 90476806
Anastomotic leak 18.71 13.42 12 141494 635 90486306
Chronic hepatitis 18.69 13.42 15 141491 1130 90485811
Obliterative bronchiolitis 18.69 13.42 22 141484 2659 90484282
Haemoglobin decreased 18.68 13.42 356 141150 161600 90325341
Renal tubular dysfunction 18.62 13.42 11 141495 502 90486439
Immunosuppression 18.60 13.42 51 141455 12026 90474915
Spinal cord compression 18.59 13.42 30 141476 4881 90482060
Granulocyte count decreased 18.57 13.42 21 141485 2431 90484510
Uterine enlargement 18.56 13.42 16 141490 1332 90485609
Aortitis 18.54 13.42 16 141490 1334 90485607
Gastrointestinal obstruction 18.52 13.42 16 141490 1336 90485605
Restless legs syndrome 18.49 13.42 6 141500 22464 90464477
Immune-mediated hypothyroidism 18.49 13.42 17 141489 1541 90485400
Pseudomonal bacteraemia 18.48 13.42 19 141487 1975 90484966
Leiomyosarcoma metastatic 18.40 13.42 5 141501 25 90486916
Enterovirus test positive 18.38 13.42 8 141498 189 90486752
Pneumonia influenzal 18.37 13.42 20 141486 2220 90484721
Axillary lymphadenectomy 18.36 13.42 7 141499 116 90486825
Enterocutaneous fistula 18.34 13.42 17 141489 1557 90485384
Cardio-respiratory arrest 18.30 13.42 45 141461 63095 90423846
Syncope 18.29 13.42 300 141206 132363 90354578
Breast neoplasm 18.28 13.42 17 141489 1563 90485378
Drug tolerance 18.28 13.42 3 141503 17913 90469028
Cancer in remission 18.23 13.42 6 141500 63 90486878
Epithelioid sarcoma 18.20 13.42 4 141502 6 90486935
Mantle cell lymphoma 18.18 13.42 12 141494 667 90486274
Atrial flutter 18.16 13.42 47 141459 10711 90476230
Shock 18.16 13.42 91 141415 28687 90458254
Breast oedema 18.14 13.42 6 141500 64 90486877
Muscle necrosis 18.08 13.42 13 141493 831 90486110
Vomiting 17.96 13.42 1446 140060 786847 89700094
Meningitis cryptococcal 17.96 13.42 18 141488 1815 90485126
Vascular device infection 17.94 13.42 50 141456 11902 90475039
Endothelial dysfunction 17.85 13.42 8 141498 203 90486738
Myelitis 17.83 13.42 19 141487 2059 90484882
Reproductive toxicity 17.82 13.42 4 141502 7 90486934
Ovarian injury 17.82 13.42 4 141502 7 90486934
Secondary cerebellar degeneration 17.82 13.42 6 141500 68 90486873
Jejunal stenosis 17.82 13.42 6 141500 68 90486873
Paranasal sinus mucosal hypertrophy 17.78 13.42 5 141501 29 90486912
Herpes zoster meningoencephalitis 17.75 13.42 10 141496 417 90486524
Myocardial stunning 17.71 13.42 9 141497 304 90486637
Type 1 diabetes mellitus 17.68 13.42 29 141477 4783 90482158
Herpes simplex viraemia 17.68 13.42 10 141496 420 90486521
Cholestasis 17.68 13.42 107 141399 36192 90450749
Artificial menopause 17.64 13.42 5 141501 30 90486911
Transient ischaemic attack 17.62 13.42 25 141481 43151 90443790
Hydrocephalus 17.56 13.42 33 141473 6061 90480880
Monoplegia 17.54 13.42 25 141481 3649 90483292
Creatinine renal clearance decreased 17.52 13.42 4 141502 18895 90468046
Hypophosphatasia 17.51 13.42 6 141500 72 90486869
Myofascitis 17.50 13.42 5 141501 31 90486910
Leukaemia recurrent 17.39 13.42 16 141490 1451 90485490
Product storage error 17.39 13.42 5 141501 20236 90466705
Irritability 17.36 13.42 18 141488 35644 90451297
Hepatitis B surface antigen positive 17.36 13.42 6 141500 74 90486867
Hyperphosphataemia 17.35 13.42 25 141481 3686 90483255
Upper limb fracture 17.34 13.42 6 141500 21572 90465369
Meningitis streptococcal 17.25 13.42 7 141499 138 90486803
Premature rupture of membranes 17.15 13.42 31 141475 5527 90481414
Vulvovaginal inflammation 17.12 13.42 14 141492 1084 90485857
Epstein Barr virus positive mucocutaneous ulcer 17.10 13.42 11 141495 585 90486356
Burning sensation 17.03 13.42 47 141459 63405 90423536
VIth nerve paresis 17.00 13.42 6 141500 79 90486862
Jejunal ulcer perforation 16.98 13.42 5 141501 35 90486906
Genitourinary symptom 16.88 13.42 7 141499 146 90486795
Coronary ostial stenosis 16.86 13.42 6 141500 81 90486860
Glioblastoma multiforme 16.85 13.42 13 141493 925 90486016
Portal hypertension 16.83 13.42 28 141478 4673 90482268
Leukocytosis 16.82 13.42 94 141412 30896 90456045
Eosinophilia 16.81 13.42 12 141494 28521 90458420
Gout 16.81 13.42 3 141503 16856 90470085
Inflammatory myofibroblastic tumour 16.80 13.42 6 141500 82 90486859
Antithrombin III decreased 16.77 13.42 8 141498 235 90486706
Mesenteric neoplasm 16.74 13.42 5 141501 37 90486904
Retinitis pigmentosa 16.67 13.42 7 141499 151 90486790
Sleep apnoea syndrome 16.64 13.42 15 141491 31732 90455209
Low birth weight baby 16.64 13.42 42 141464 9425 90477516
Blood uric acid increased 16.60 13.42 37 141469 7667 90479274
Neonatal lupus erythematosus 16.59 13.42 4 141502 11 90486930
Alopecia areata 16.54 13.42 18 141488 1997 90484944
Tumour ulceration 16.52 13.42 8 141498 243 90486698
Metastases to stomach 16.52 13.42 8 141498 243 90486698
Mouth ulceration 16.50 13.42 113 141393 39861 90447080
Necrotising fasciitis 16.50 13.42 25 141481 3855 90483086
Blood magnesium decreased 16.48 13.42 58 141448 15635 90471306
Transaminases increased 16.47 13.42 107 141399 37085 90449856
Hepatitis G 16.47 13.42 6 141500 87 90486854
Hyperuricaemia 16.47 13.42 34 141472 6685 90480256
Poor quality sleep 16.47 13.42 9 141497 24684 90462257
Central nervous system viral infection 16.46 13.42 7 141499 156 90486785
Tumour rupture 16.40 13.42 8 141498 247 90486694
Endometrial cancer 16.40 13.42 24 141482 3588 90483353
Medical device site oedema 16.39 13.42 3 141503 0 90486941
Abdominal distension 16.33 13.42 128 141378 130473 90356468
Infusion site joint movement impairment 16.33 13.42 4 141502 12 90486929
Clostridium colitis 16.32 13.42 18 141488 2027 90484914
Hyponatraemia 16.25 13.42 296 141210 133242 90353699
Mood swings 16.22 13.42 6 141500 20696 90466245
Incorrect product administration duration 16.18 13.42 5 141501 19317 90467624
Immune-mediated thyroiditis 16.14 13.42 10 141496 498 90486443
Acral peeling skin syndrome 16.09 13.42 4 141502 13 90486928
Non-cirrhotic portal hypertension 16.07 13.42 9 141497 371 90486570
Portal vein embolism 16.05 13.42 6 141500 94 90486847
Gastrointestinal disorder 16.04 13.42 293 141213 256394 90230547
Performance status decreased 16.01 13.42 26 141480 4254 90482687
Radiation pneumonitis 15.96 13.42 17 141489 1841 90485100
Respiratory disorder 15.96 13.42 50 141456 64766 90422175
Listeria encephalitis 15.94 13.42 8 141498 263 90486678
Human herpesvirus 6 infection 15.87 13.42 23 141483 3409 90483532
Platelet disorder 15.86 13.42 19 141487 2340 90484601
Cardiac failure congestive 15.83 13.42 229 141277 98465 90388476
Bladder perforation 15.83 13.42 7 141499 172 90486769
Right ventricular dysfunction 15.82 13.42 19 141487 2345 90484596
Systemic toxicity 15.80 13.42 8 141498 268 90486673
Candida sepsis 15.77 13.42 16 141490 1637 90485304
Adenoviral haemorrhagic cystitis 15.75 13.42 7 141499 174 90486767
Leukoplakia oral 15.75 13.42 8 141498 270 90486671
Metastases to retroperitoneum 15.71 13.42 7 141499 175 90486766
Aspartate aminotransferase abnormal 15.66 13.42 20 141486 2629 90484312
Delirium 15.65 13.42 97 141409 104262 90382679
Cytology abnormal 15.65 13.42 4 141502 15 90486926
Blood pressure decreased 15.61 13.42 62 141444 74833 90412108
Lymphangioleiomyomatosis 15.59 13.42 8 141498 276 90486665
Varicose vein 15.58 13.42 35 141471 7292 90479649
Renal tubular disorder 15.57 13.42 22 141484 3185 90483756
Osmotic demyelination syndrome 15.51 13.42 13 141493 1041 90485900
Rotator cuff syndrome 15.51 13.42 3 141503 15916 90471025
C-reactive protein increased 15.47 13.42 195 141311 181194 90305747
Toxic skin eruption 15.46 13.42 57 141449 15717 90471224
Ovarian cancer stage IV 15.45 13.42 8 141498 281 90486660
Abnormal behaviour 15.45 13.42 8 141498 22620 90464321
Renal pseudoaneurysm 15.44 13.42 4 141502 16 90486925
Beta 2 microglobulin decreased 15.44 13.42 4 141502 16 90486925
Trichodysplasia spinulosa 15.44 13.42 11 141495 693 90486248
Bone density decreased 15.43 13.42 4 141502 17341 90469600
Aspartate aminotransferase increased 15.40 13.42 236 141270 102701 90384240
Central nervous system infection 15.37 13.42 12 141494 869 90486072
Salmonella sepsis 15.35 13.42 8 141498 285 90486656
Genital infection 15.29 13.42 7 141499 187 90486754
Immune-mediated enterocolitis 15.28 13.42 27 141479 4730 90482211
Metastases to vagina 15.25 13.42 4 141502 17 90486924
Device related bacteraemia 15.25 13.42 9 141497 410 90486531
Coronary artery disease 15.24 13.42 18 141488 33605 90453336
Rhabdomyosarcoma 15.23 13.42 6 141500 109 90486832
Hypovolaemic shock 15.21 13.42 34 141472 7060 90479881
Tricuspid valve incompetence 15.20 13.42 59 141447 16672 90470269
Splenic marginal zone lymphoma 15.15 13.42 5 141501 53 90486888
Peritonitis 15.14 13.42 66 141440 19639 90467302
Full blood count abnormal 15.13 13.42 21 141485 36576 90450365
Wrist fracture 15.11 13.42 3 141503 15621 90471320
Paraneoplastic pemphigus 15.08 13.42 6 141500 112 90486829
Duodenal perforation 15.05 13.42 13 141493 1085 90485856
Hypoglossal nerve paresis 15.04 13.42 6 141500 113 90486828
Thrombophlebitis 14.99 13.42 27 141479 4801 90482140
Agitation 14.99 13.42 54 141452 67044 90419897
Escherichia sepsis 14.93 13.42 30 141476 5786 90481155
Blood pressure diastolic decreased 14.89 13.42 12 141494 26814 90460127
Glioma 14.82 13.42 9 141497 432 90486509
Hypersensitivity pneumonitis 14.79 13.42 24 141482 3924 90483017
Post thrombotic syndrome 14.77 13.42 10 141496 580 90486361
Lymph node fibrosis 14.72 13.42 4 141502 20 90486921
Malignant neoplasm of orbit 14.72 13.42 4 141502 20 90486921
Rhinitis allergic 14.69 13.42 4 141502 16781 90470160
Tumour flare 14.68 13.42 10 141496 586 90486355
Procalcitonin increased 14.67 13.42 15 141491 1549 90485392
Retroperitoneal mass 14.61 13.42 6 141500 122 90486819
Marginal zone lymphoma recurrent 14.56 13.42 4 141502 21 90486920
Affect lability 14.56 13.42 5 141501 18058 90468883
Vessel puncture site bruise 14.54 13.42 9 141497 447 90486494
Abortion spontaneous 14.54 13.42 40 141466 54016 90432925
Rectal fissure 14.50 13.42 11 141495 763 90486178
Pyloric stenosis 14.47 13.42 9 141497 451 90486490
Metastases to abdominal cavity 14.47 13.42 10 141496 600 90486341
Osteopenia 14.46 13.42 9 141497 22993 90463948
Bartholinitis 14.44 13.42 5 141501 62 90486879
Cyst 14.39 13.42 4 141502 16557 90470384
Chondrosarcoma metastatic 14.32 13.42 3 141503 3 90486938
Tumour associated fever 14.31 13.42 9 141497 460 90486481
HER2 positive breast cancer 14.29 13.42 9 141497 461 90486480
Ventricular remodelling 14.25 13.42 4 141502 23 90486918
Epilepsy 14.17 13.42 73 141433 82133 90404808
Arthritis fungal 14.16 13.42 5 141501 66 90486875
Hypersomnia 14.14 13.42 8 141498 21523 90465418
Syphilis 14.12 13.42 7 141499 224 90486717
Disturbance in attention 14.11 13.42 33 141473 47076 90439865
Rash macular 13.95 13.42 16 141490 30264 90456677
Lung opacity 13.94 13.42 30 141476 6072 90480869
Faeces discoloured 13.89 13.42 8 141498 21312 90465629
Diffuse alopecia 13.87 13.42 13 141493 1207 90485734
Vertebral column mass 13.84 13.42 7 141499 234 90486707
Infusion site ulcer 13.84 13.42 4 141502 26 90486915
Campylobacter gastroenteritis 13.83 13.42 11 141495 818 90486123
Scleroderma-like reaction 13.81 13.42 6 141500 141 90486800
Parotitis 13.76 13.42 16 141490 1909 90485032
Ageusia 13.76 13.42 4 141502 16072 90470869
Mastitis 13.75 13.42 20 141486 2973 90483968
Large intestinal obstruction 13.75 13.42 19 141487 2695 90484246
Movement disorder 13.73 13.42 15 141491 29004 90457937
Post-acute COVID-19 syndrome 13.72 13.42 13 141493 1224 90485717
Ligament sprain 13.71 13.42 3 141503 14596 90472345
Rosai-Dorfman syndrome 13.71 13.42 4 141502 27 90486914
Haemobilia 13.69 13.42 6 141500 144 90486797
Hypercalcaemia 13.67 13.42 96 141410 34144 90452797
Granuloma 13.66 13.42 30 141476 6155 90480786
Hallucination, auditory 13.62 13.42 4 141502 15971 90470970
Enanthema 13.62 13.42 9 141497 501 90486440
Epstein-Barr viraemia 13.61 13.42 14 141492 1456 90485485
Disseminated mucormycosis 13.61 13.42 10 141496 661 90486280
Glomerulonephritis 13.59 13.42 18 141488 2452 90484489
Drug reaction with eosinophilia and systemic symptoms 13.59 13.42 29 141477 42729 90444212
Crying 13.58 13.42 12 141494 25633 90461308
Osteosarcoma 13.58 13.42 6 141500 147 90486794
Hepatitis C RNA increased 13.54 13.42 6 141500 148 90486793
Madarosis 13.51 13.42 22 141484 3607 90483334
Pulmonary mass 13.50 13.42 84 141422 28688 90458253
Cholangitis sclerosing 13.49 13.42 17 141489 2204 90484737
Renal disorder 13.48 13.42 24 141482 37835 90449106
Scintillating scotoma 13.47 13.42 6 141500 150 90486791
Necrotising soft tissue infection 13.47 13.42 7 141499 248 90486693
Cortisol abnormal 13.45 13.42 5 141501 77 90486864
Neutrophil count increased 13.45 13.42 63 141443 19327 90467614

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5056.90 14.01 4044 107840 181659 42327792
Disease progression 2984.58 14.01 2684 109200 140972 42368479
Neutropenia 1699.14 14.01 2338 109546 197093 42312358
Diffuse large B-cell lymphoma recurrent 1076.35 14.01 425 111459 4461 42504990
Off label use 1022.80 14.01 3818 108066 634517 41874934
Mucosal inflammation 789.52 14.01 801 111083 48573 42460878
Myelosuppression 762.01 14.01 718 111166 39743 42469708
Haematotoxicity 753.37 14.01 427 111457 10558 42498893
Second primary malignancy 702.32 14.01 389 111495 9186 42500265
Cardiotoxicity 625.53 14.01 331 111553 7114 42502337
Product use in unapproved indication 616.65 14.01 1439 110445 183017 42326434
Acute myeloid leukaemia 581.71 14.01 476 111408 21780 42487671
Hepatitis B 557.13 14.01 296 111588 6415 42503036
Tumour lysis syndrome 557.10 14.01 464 111420 21767 42487684
Hepatitis B reactivation 548.54 14.01 259 111625 4319 42505132
Thrombocytopenia 534.64 14.01 1389 110495 188890 42320561
Pancytopenia 524.87 14.01 1033 110851 116710 42392741
Therapy partial responder 522.80 14.01 428 111456 19593 42489858
Myelodysplastic syndrome 521.32 14.01 451 111433 22294 42487157
Neoplasm progression 508.63 14.01 495 111389 28505 42480946
Cytokine release syndrome 439.86 14.01 563 111321 43964 42465487
Bone marrow failure 414.42 14.01 472 111412 32621 42476830
Leukopenia 374.97 14.01 690 111194 74056 42435395
Progressive multifocal leukoencephalopathy 362.25 14.01 275 111609 11261 42498190
Diffuse large B-cell lymphoma refractory 351.72 14.01 148 111736 1849 42507602
Product dose omission issue 344.79 14.01 14 111870 154351 42355100
Septic shock 331.90 14.01 739 111145 90933 42418518
Disease recurrence 314.88 14.01 389 111495 29289 42480162
Febrile bone marrow aplasia 311.54 14.01 239 111645 9942 42499509
Neutropenic sepsis 292.35 14.01 279 111605 15667 42493784
Cytopenia 285.07 14.01 287 111597 17210 42492241
Blood lactate dehydrogenase increased 276.91 14.01 342 111542 25739 42483712
Hypogammaglobulinaemia 274.84 14.01 237 111647 11654 42497797
Pneumocystis jirovecii pneumonia 273.48 14.01 334 111550 24847 42484604
Neuropathy peripheral 268.53 14.01 727 111157 101126 42408325
Malignant neoplasm progression 268.25 14.01 756 111128 107644 42401807
Neutrophil count decreased 267.28 14.01 544 111340 62871 42446580
Fall 256.22 14.01 149 111735 234371 42275080
Cytomegalovirus chorioretinitis 249.88 14.01 154 111730 4457 42504994
Lymphadenopathy 249.63 14.01 369 111515 32996 42476455
Rash 246.41 14.01 219 111665 276735 42232716
Arthralgia 239.34 14.01 120 111764 205118 42304333
Sepsis 236.08 14.01 1092 110792 198242 42311209
Diffuse large B-cell lymphoma 231.93 14.01 195 111689 9259 42500192
Pyrexia 222.54 14.01 1779 110105 392263 42117188
Dizziness 217.00 14.01 201 111683 249053 42260398
B-cell lymphoma recurrent 214.68 14.01 82 111802 780 42508671
Acquired gene mutation 203.54 14.01 94 111790 1486 42507965
Anxiety 202.29 14.01 34 111850 118526 42390925
Fatigue 191.84 14.01 551 111333 435090 42074361
Mantle cell lymphoma recurrent 190.86 14.01 79 111805 944 42508507
Somnolence 189.26 14.01 67 111817 141038 42368413
Pruritus 186.88 14.01 134 111750 188637 42320814
Cardiomyopathy 180.35 14.01 237 111647 18973 42490478
Drug ineffective 176.17 14.01 2467 109417 627730 41881721
Myocardial infarction 174.85 14.01 54 111830 123955 42385496
Drug interaction 171.31 14.01 273 111611 266726 42242725
Posterior reversible encephalopathy syndrome 167.45 14.01 187 111697 12634 42496817
Anaemia 165.85 14.01 1280 110604 278998 42230453
Neoplasm recurrence 165.73 14.01 98 111786 2626 42506825
Inappropriate schedule of product administration 164.70 14.01 27 111857 95875 42413576
Dyspnoea 162.83 14.01 606 111278 442015 42067436
Pain in extremity 159.66 14.01 99 111785 150505 42358946
Blood pressure increased 155.64 14.01 38 111846 101890 42407561
Muscle spasms 155.18 14.01 21 111863 86023 42423428
Neurotoxicity 154.93 14.01 246 111638 23405 42486046
Lymphoma 150.69 14.01 187 111697 14134 42495317
Pain 148.08 14.01 260 111624 244588 42264863
Polyneuropathy 141.87 14.01 208 111676 18453 42490998
Ejection fraction decreased 140.93 14.01 227 111657 21860 42487591
Rhabdomyolysis 140.79 14.01 19 111865 78000 42431451
Intentional product misuse 140.20 14.01 5 111879 61895 42447556
Headache 139.54 14.01 260 111624 239109 42270342
Depression 139.16 14.01 59 111825 111304 42398147
Drug hypersensitivity 138.80 14.01 44 111840 99345 42410106
Weight increased 138.51 14.01 55 111829 107928 42401523
Overdose 137.69 14.01 52 111832 105212 42404239
Joint swelling 137.03 14.01 11 111873 68011 42441440
Hospitalisation 136.78 14.01 17 111867 74313 42435138
Insomnia 136.42 14.01 70 111814 118183 42391268
Candida infection 132.32 14.01 218 111666 21392 42488059
Central nervous system lymphoma 131.88 14.01 67 111817 1318 42508133
Tremor 126.58 14.01 48 111836 96881 42412570
Peripheral swelling 125.98 14.01 40 111844 90230 42419221
Feeling abnormal 125.90 14.01 17 111867 69769 42439682
Confusional state 118.47 14.01 160 111724 167437 42342014
Cytomegalovirus infection 117.35 14.01 261 111623 32045 42477406
Aspergillus infection 115.32 14.01 173 111711 15664 42493787
Myalgia 115.16 14.01 54 111830 96026 42413425
Suicidal ideation 112.27 14.01 3 111881 48158 42461293
Herpes simplex 109.39 14.01 113 111771 6982 42502469
Musculoskeletal stiffness 109.29 14.01 12 111872 57753 42451698
Venoocclusive liver disease 109.15 14.01 135 111749 10167 42499284
Haemophagocytic lymphohistiocytosis 109.12 14.01 182 111702 18040 42491411
Epstein-Barr virus infection 108.89 14.01 131 111753 9587 42499864
Injection site pain 106.87 14.01 13 111871 57785 42451666
Therapy non-responder 106.24 14.01 345 111539 53014 42456437
White blood cell count decreased 105.73 14.01 570 111314 109826 42399625
Malaise 103.92 14.01 254 111630 211902 42297549
Immune effector cell-associated neurotoxicity syndrome 103.51 14.01 126 111758 9335 42500116
Cystitis haemorrhagic 102.81 14.01 111 111773 7218 42502233
Nasopharyngitis 102.54 14.01 46 111838 83950 42425501
Stress 102.15 14.01 3 111881 44209 42465242
COVID-19 101.29 14.01 584 111300 115364 42394087
Death 101.02 14.01 774 111110 470411 42039040
Loss of personal independence in daily activities 100.49 14.01 8 111876 49808 42459643
Sweat gland tumour 99.85 14.01 39 111845 396 42509055
Asthma 99.56 14.01 21 111863 62293 42447158
Sleep disorder 99.07 14.01 7 111877 48088 42461363
Bradycardia 97.97 14.01 51 111833 85433 42424018
Suicide attempt 97.05 14.01 6 111878 46094 42463357
Agranulocytosis 95.50 14.01 233 111651 30379 42479072
Abdominal discomfort 95.39 14.01 39 111845 75216 42434235
Gastrointestinal toxicity 95.38 14.01 81 111803 3898 42505553
Incorrect dose administered 95.32 14.01 13 111871 52961 42456490
Drug resistance 94.68 14.01 249 111635 33999 42475452
Wheezing 92.74 14.01 16 111868 54765 42454686
Aggression 92.22 14.01 6 111878 44157 42465294
Cytomegalovirus infection reactivation 91.41 14.01 129 111755 11049 42498402
Rheumatoid arthritis 90.94 14.01 5 111879 42435 42467016
Chronic obstructive pulmonary disease 89.78 14.01 27 111857 63087 42446364
Cerebrovascular accident 89.63 14.01 74 111810 97086 42412365
Stomatitis 89.23 14.01 313 111571 50016 42459435
Blood glucose increased 87.42 14.01 42 111842 73657 42435794
Lymphoma transformation 85.65 14.01 37 111847 495 42508956
Azoospermia 85.52 14.01 37 111847 497 42508954
Escherichia sepsis 84.07 14.01 89 111795 5658 42503793
Lymphopenia 83.75 14.01 179 111705 21384 42488067
Psoriasis 82.71 14.01 14 111870 48590 42460861
Myelopathy 82.20 14.01 65 111819 2826 42506625
Dry skin 82.09 14.01 14 111870 48324 42461127
Oedema peripheral 81.68 14.01 145 111739 135931 42373520
Plasma cell myeloma refractory 81.28 14.01 49 111835 1361 42508090
Post transplant lymphoproliferative disorder 80.19 14.01 109 111775 9011 42500440
Coronary artery disease 80.09 14.01 21 111863 53699 42455752
Chest pain 79.05 14.01 154 111730 139376 42370075
Infection 78.81 14.01 534 111350 111534 42397917
Intestinal perforation 78.05 14.01 118 111766 10756 42498695
Peripheral sensory neuropathy 77.47 14.01 105 111779 8657 42500794
Left ventricular dysfunction 77.21 14.01 121 111763 11380 42498071
Gait disturbance 76.06 14.01 87 111797 97913 42411538
Neutropenic colitis 75.88 14.01 75 111809 4395 42505056
Strongyloidiasis 74.47 14.01 66 111818 3365 42506086
Hallucination 74.19 14.01 29 111855 57478 42451973
Contusion 73.91 14.01 11 111873 41974 42467477
Blood creatine phosphokinase increased 73.79 14.01 18 111866 48320 42461131
Hepatic failure 73.72 14.01 244 111640 37856 42471595
Heart rate decreased 73.31 14.01 6 111878 36526 42472925
Anaplastic lymphoma kinase gene mutation 70.68 14.01 22 111862 104 42509347
Bronchopulmonary aspergillosis 70.58 14.01 157 111727 19272 42490179
Nephropathy toxic 70.32 14.01 144 111740 16694 42492757
Hypoglycaemia 69.63 14.01 35 111849 59819 42449632
Pneumonitis 69.30 14.01 254 111630 41464 42467987
B-cell lymphoma refractory 69.23 14.01 25 111859 200 42509251
Viral haemorrhagic cystitis 69.04 14.01 49 111835 1805 42507646
Hyperhidrosis 68.47 14.01 82 111802 90430 42419021
Multiple organ dysfunction syndrome 67.98 14.01 462 111422 96573 42412878
Osteonecrosis 67.82 14.01 137 111747 15728 42493723
Agitation 67.09 14.01 43 111841 64271 42445180
Peripheral T-cell lymphoma unspecified 65.64 14.01 32 111852 574 42508877
Hypertension 65.13 14.01 223 111661 166981 42342470
Urticaria 63.91 14.01 60 111824 73976 42435475
JC virus infection 63.64 14.01 57 111827 2947 42506504
Product use issue 63.37 14.01 381 111503 76370 42433081
Venoocclusive disease 63.34 14.01 64 111820 3851 42505600
Respiratory failure 63.08 14.01 562 111322 127570 42381881
Loss of consciousness 62.37 14.01 91 111793 92263 42417188
Eczema 62.19 14.01 8 111876 34078 42475373
Refractory cancer 61.81 14.01 22 111862 168 42509283
Heart rate increased 60.67 14.01 32 111852 53223 42456228
Cardio-respiratory arrest 58.74 14.01 41 111843 58595 42450856
Glioma 58.68 14.01 28 111856 478 42508973
Abdominal pain upper 58.17 14.01 79 111805 82530 42426921
Escherichia infection 58.04 14.01 106 111778 11290 42498161
Blood cholesterol increased 57.76 14.01 3 111881 26738 42482713
Erythema 57.43 14.01 125 111759 108668 42400783
Vision blurred 57.25 14.01 35 111849 53664 42455787
Pneumonia fungal 56.97 14.01 93 111791 9053 42500398
Skin exfoliation 56.91 14.01 19 111865 41534 42467917
Staphylococcal sepsis 56.66 14.01 105 111779 11309 42498142
Malignant transformation 56.41 14.01 34 111850 944 42508507
Bacteraemia 56.37 14.01 169 111715 24871 42484580
Epstein-Barr virus associated lymphoma 56.22 14.01 35 111849 1031 42508420
Product prescribing error 56.18 14.01 3 111881 26109 42483342
Memory impairment 56.01 14.01 31 111853 50191 42459260
Hepatotoxicity 55.85 14.01 169 111715 24998 42484453
Diarrhoea 55.81 14.01 863 111021 459986 42049465
Administration site extravasation 55.33 14.01 31 111853 748 42508703
Arthropathy 53.87 14.01 7 111877 29590 42479861
Angioedema 53.83 14.01 22 111862 42455 42466996
Traumatic lung injury 53.79 14.01 37 111847 1295 42508156
Nightmare 53.42 14.01 3 111881 25009 42484442
Accidental overdose 53.29 14.01 6 111878 28324 42481127
Drug ineffective for unapproved indication 53.03 14.01 251 111633 45912 42463539
Pneumonia klebsiella 52.35 14.01 60 111824 4169 42505282
Aplasia 52.16 14.01 64 111820 4779 42504672
Nephrolithiasis 51.93 14.01 16 111868 36814 42472637
Osteoarthritis 51.90 14.01 3 111881 24402 42485049
Ill-defined disorder 51.84 14.01 125 111759 16171 42493280
Nausea 51.84 14.01 732 111152 396067 42113384
Pseudomonal bacteraemia 51.82 14.01 46 111838 2350 42507101
BK virus infection 51.60 14.01 87 111797 8697 42500754
Anal inflammation 50.63 14.01 44 111840 2185 42507266
Toxic cardiomyopathy 50.23 14.01 24 111860 411 42509040
Weight decreased 50.00 14.01 330 111554 207618 42301833
Blood pressure systolic increased 49.99 14.01 7 111877 27961 42481490
Gastrooesophageal reflux disease 49.90 14.01 28 111856 44995 42464456
Toxoplasmosis 49.75 14.01 38 111846 1569 42507882
Haematochezia 49.68 14.01 48 111836 58388 42451063
Post embolisation syndrome 49.06 14.01 15 111869 66 42509385
Device related thrombosis 48.81 14.01 36 111848 1409 42508042
Cardiac failure 48.68 14.01 461 111423 106395 42403056
Mobility decreased 48.60 14.01 16 111868 35290 42474161
Blood pressure decreased 48.34 14.01 49 111835 58283 42451168
Metastases to lung 48.06 14.01 98 111786 11326 42498125
Illness 47.60 14.01 5 111879 24925 42484526
Fungal infection 47.15 14.01 136 111748 19586 42489865
Cerebral toxoplasmosis 46.82 14.01 41 111843 2057 42507394
Swelling 46.76 14.01 45 111839 54840 42454611
Chest discomfort 46.66 14.01 59 111825 63557 42445894
Therapy interrupted 46.52 14.01 3 111881 22247 42487204
Salivary gland cancer 46.52 14.01 21 111863 314 42509137
Acute lymphocytic leukaemia 46.44 14.01 51 111833 3380 42506071
SARS-CoV-2 test negative 46.41 14.01 38 111846 1737 42507714
Gene mutation 46.30 14.01 38 111846 1743 42507708
Cardiac failure congestive 45.46 14.01 98 111786 85504 42423947
Transient ischaemic attack 45.21 14.01 16 111868 33723 42475728
Hyperkalaemia 44.50 14.01 90 111794 80368 42429083
Glioblastoma multiforme 44.11 14.01 28 111856 854 42508597
Arthritis 44.04 14.01 28 111856 42037 42467414
Pneumonia 44.01 14.01 1433 110451 420716 42088735
Renal-limited thrombotic microangiopathy 43.93 14.01 19 111865 255 42509196
Dry mouth 43.91 14.01 25 111859 39854 42469597
Treatment noncompliance 43.85 14.01 22 111862 37650 42471801
Chloroma 43.83 14.01 24 111860 553 42508898
Cardiac dysfunction 43.39 14.01 49 111835 3350 42506101
Visual impairment 43.37 14.01 30 111854 43083 42466368
Unevaluable event 43.06 14.01 18 111866 34270 42475181
International normalised ratio increased 42.80 14.01 38 111846 48130 42461321
Hepatopulmonary syndrome 42.78 14.01 15 111869 109 42509342
Metastasis 42.53 14.01 57 111827 4648 42504803
Blood stem cell transplant failure 42.49 14.01 22 111862 451 42509000
Bone formation decreased 42.37 14.01 11 111873 22 42509429
Gastritis bacterial 42.31 14.01 20 111864 334 42509117
Back pain 42.12 14.01 210 111674 141566 42367885
Autoimmune neutropenia 42.10 14.01 20 111864 338 42509113
Toxic erythema of chemotherapy 42.09 14.01 16 111868 150 42509301
Therapy cessation 42.04 14.01 3 111881 20447 42489004
Drug withdrawal syndrome 41.98 14.01 4 111880 21545 42487906
Adverse drug reaction 41.89 14.01 23 111861 37411 42472040
Haematopoietic stem cell mobilisation 41.89 14.01 20 111864 342 42509109
Acute lymphocytic leukaemia recurrent 41.75 14.01 50 111834 3641 42505810
Frequent bowel movements 41.64 14.01 4 111880 21403 42488048
COVID-19 pneumonia 41.43 14.01 138 111746 21475 42487976
Autoimmune lymphoproliferative syndrome 41.30 14.01 17 111867 200 42509251
Lung infiltration 41.01 14.01 104 111780 13885 42495566
Fluid retention 40.68 14.01 16 111868 31603 42477848
Small intestinal perforation 40.30 14.01 44 111840 2897 42506554
Obstructive airways disorder 40.25 14.01 8 111876 24751 42484700
Unresponsive to stimuli 40.22 14.01 16 111868 31387 42478064
Fanconi syndrome 39.92 14.01 35 111849 1759 42507692
Immunosuppression 39.77 14.01 76 111808 8377 42501074
Interstitial lung disease 39.53 14.01 346 111538 78116 42431335
Infection reactivation 39.46 14.01 38 111846 2156 42507295
Congenital cardiovascular anomaly 39.43 14.01 16 111868 181 42509270
Klebsiella infection 39.40 14.01 90 111794 11242 42498209
Blood HIV RNA increased 39.39 14.01 33 111851 1558 42507893
Depressed mood 39.20 14.01 7 111877 23377 42486074
Neoplasm 39.12 14.01 64 111820 6241 42503210
Chylothorax 39.10 14.01 29 111855 1145 42508306
Psychotic disorder 38.88 14.01 14 111870 29194 42480257
Osteosarcoma recurrent 38.88 14.01 14 111870 111 42509340
Oxygen saturation decreased 38.72 14.01 69 111815 64618 42444833
Injection site erythema 38.69 14.01 4 111880 20191 42489260
Psoriatic arthropathy 38.69 14.01 9 111875 24958 42484493
Road traffic accident 38.68 14.01 3 111881 19090 42490361
Spinal column injury 38.63 14.01 23 111861 624 42508827
Transformation to acute myeloid leukaemia 38.39 14.01 28 111856 1077 42508374
Ventricular dysfunction 38.35 14.01 53 111831 4450 42505001
Dysgeusia 38.27 14.01 21 111863 34168 42475283
Marginal zone lymphoma recurrent 38.17 14.01 12 111872 59 42509392
Plasmacytoma 38.13 14.01 52 111832 4312 42505139
Klebsiella sepsis 38.04 14.01 41 111843 2660 42506791
Cytogenetic abnormality 37.92 14.01 26 111858 905 42508546
Streptococcal infection 37.71 14.01 62 111822 6070 42503381
Haemorrhage 37.71 14.01 63 111821 60500 42448951
Myelitis transverse 37.69 14.01 30 111854 1317 42508134
Clostridium difficile colitis 37.50 14.01 132 111752 21120 42488331
Vertigo 37.15 14.01 22 111862 34325 42475126
Disorientation 37.03 14.01 25 111859 36364 42473087
Irritability 36.58 14.01 14 111870 28114 42481337
Condition aggravated 36.51 14.01 474 111410 260280 42249171
Platelet count decreased 36.44 14.01 538 111346 138043 42371408
Drug reaction with eosinophilia and systemic symptoms 36.42 14.01 34 111850 42041 42467410
Pseudomonas infection 36.34 14.01 108 111776 15815 42493636
Staphylococcal bacteraemia 36.12 14.01 86 111798 11035 42498416
Diabetes mellitus 36.04 14.01 64 111820 60023 42449428
Recurrent cancer 35.95 14.01 32 111852 1641 42507810
Metastases to spleen 35.46 14.01 20 111864 489 42508962
Cardiac arrest 35.36 14.01 157 111727 109163 42400288
Asthenia 35.19 14.01 522 111362 280271 42229180
Endocarditis noninfective 35.18 14.01 14 111870 150 42509301
Hepatic fibrosis 35.15 14.01 53 111831 4819 42504632
Balance disorder 35.13 14.01 44 111840 47601 42461850
Bone marrow disorder 34.97 14.01 34 111850 1952 42507499
Subdural hygroma 34.88 14.01 19 111865 433 42509018
Head injury 34.85 14.01 6 111878 20576 42488875
Follicular lymphoma 34.84 14.01 19 111865 434 42509017
Hot flush 34.74 14.01 8 111876 22343 42487108
Pneumocystis jirovecii infection 34.43 14.01 40 111844 2820 42506631
Flushing 34.37 14.01 28 111856 37000 42472451
Congestive cardiomyopathy 34.31 14.01 73 111811 8691 42500760
Swollen tongue 34.22 14.01 7 111877 21224 42488227
Lip swelling 33.51 14.01 5 111879 19048 42490403
Medication error 33.44 14.01 23 111861 33131 42476320
Bronchiectasis 33.43 14.01 4 111880 18015 42491436
Prostatic specific antigen increased 33.35 14.01 3 111881 16922 42492529
Syncope 33.22 14.01 141 111743 99265 42410186
Product quality issue 33.10 14.01 4 111880 17878 42491573
Dehydration 33.03 14.01 227 111657 141540 42367911
Peripheral motor neuropathy 33.01 14.01 35 111849 2229 42507222
Pleural effusion 32.91 14.01 395 111489 96771 42412680
Human herpesvirus 8 infection 32.90 14.01 29 111855 1468 42507983
Fat embolism syndrome 32.75 14.01 11 111873 69 42509382
Colitis 32.74 14.01 222 111662 46350 42463101
Thrombosis 32.71 14.01 83 111801 68428 42441023
Pleuroparenchymal fibroelastosis 32.61 14.01 13 111871 140 42509311
Electrocardiogram QT prolonged 32.59 14.01 47 111837 47898 42461553
Amnesia 32.51 14.01 17 111867 28420 42481031
Surgery 32.46 14.01 4 111880 17612 42491839
Retinal haemorrhage 32.38 14.01 56 111828 5714 42503737
Swelling face 32.21 14.01 16 111868 27538 42481913
Ganglioneuroblastoma 32.10 14.01 9 111875 27 42509424
Discomfort 32.05 14.01 13 111871 25206 42484245
Cough 31.94 14.01 306 111578 177797 42331654
Toxicity to various agents 31.89 14.01 417 111467 228719 42280732
Abdominal neoplasm 31.84 14.01 18 111866 442 42509009
Product administration error 31.84 14.01 5 111879 18338 42491113
Wrong technique in product usage process 31.83 14.01 39 111845 42596 42466855
Burning sensation 31.72 14.01 8 111876 21005 42488446
Granulocyte count decreased 31.71 14.01 29 111855 1541 42507910
Leukoencephalopathy 31.70 14.01 51 111833 4903 42504548
Peripheral sensorimotor neuropathy 31.66 14.01 32 111852 1926 42507525
Constipation 31.64 14.01 273 111611 162018 42347433
Pulmonary toxicity 31.50 14.01 70 111814 8585 42500866
Anaplastic large cell lymphoma T- and null-cell types recurrent 31.34 14.01 10 111874 52 42509399
Restlessness 31.26 14.01 19 111865 29230 42480221
Heart rate irregular 31.21 14.01 3 111881 16047 42493404
Sleep apnoea syndrome 31.16 14.01 9 111875 21599 42487852
Lactic acidosis 31.13 14.01 44 111840 45217 42464234
Mass 31.04 14.01 70 111814 8669 42500782
Metastatic lymphoma 30.88 14.01 17 111867 396 42509055
Hypoaesthesia 30.81 14.01 91 111793 71372 42438079
Stevens-Johnson syndrome 30.61 14.01 10 111874 22168 42487283
Laboratory test abnormal 30.61 14.01 11 111873 22967 42486484
Injection site reaction 30.41 14.01 3 111881 15718 42493733
Eosinophilia 30.39 14.01 25 111859 32874 42476577
Splenic lesion 30.38 14.01 16 111868 340 42509111
Systemic candida 30.34 14.01 52 111832 5267 42504184
Accidental exposure to product 30.34 14.01 8 111876 20385 42489066
Gastrosplenic fistula 30.29 14.01 10 111874 59 42509392
5q minus syndrome 30.20 14.01 12 111872 128 42509323
Labelled drug-drug interaction medication error 30.07 14.01 3 111881 15579 42493872
Synovitis 30.04 14.01 3 111881 15564 42493887
Meningitis cryptococcal 30.02 14.01 40 111844 3243 42506208
Bone marrow necrosis 29.95 14.01 15 111869 286 42509165
Metastases to meninges 29.81 14.01 31 111853 1930 42507521
Humoral immune defect 29.80 14.01 16 111868 354 42509097
Resorption bone increased 29.71 14.01 15 111869 291 42509160
Bone marrow infiltration 29.66 14.01 14 111870 233 42509218
End stage renal disease 29.35 14.01 103 111781 16455 42492996
Rash pruritic 29.26 14.01 27 111857 33576 42475875
Osteosarcoma 29.17 14.01 15 111869 303 42509148
Influenza 29.16 14.01 76 111808 62099 42447352
Productive cough 29.09 14.01 57 111827 51510 42457941
Acute myelomonocytic leukaemia 28.94 14.01 13 111871 192 42509259
Graft versus host disease 28.86 14.01 87 111797 12838 42496613
Respiratory depression 28.84 14.01 7 111877 18861 42490590
Alpha haemolytic streptococcal infection 28.79 14.01 30 111854 1872 42507579
Chromosome analysis abnormal 28.76 14.01 13 111871 195 42509256
Coma 28.68 14.01 61 111823 53493 42455958
Chronic myeloid leukaemia 28.58 14.01 34 111850 2458 42506993
Skin toxicity 28.52 14.01 57 111827 6492 42502959
Pneumothorax spontaneous 28.40 14.01 21 111863 825 42508626
Hepatitis E 28.38 14.01 38 111846 3096 42506355
Secondary immunodeficiency 28.18 14.01 21 111863 835 42508616
Hallucination, visual 28.11 14.01 10 111874 21010 42488441
Delirium 27.98 14.01 60 111824 52459 42456992
B-lymphocyte count decreased 27.90 14.01 21 111863 848 42508603
Migraine 27.88 14.01 16 111868 25398 42484053
Haemoptysis 27.84 14.01 49 111835 46118 42463333
Blood urea increased 27.79 14.01 27 111857 32766 42476685
Abdominal distension 27.67 14.01 96 111788 71639 42437812
Stomatococcal infection 27.45 14.01 13 111871 218 42509233
Primitive neuroectodermal tumour 27.37 14.01 10 111874 83 42509368
Hypertriglyceridaemia 27.34 14.01 73 111811 10053 42499398
Extrapyramidal disorder 27.32 14.01 5 111879 16407 42493044
Hypotension 27.28 14.01 494 111390 257137 42252314
Gastric perforation 27.24 14.01 37 111847 3056 42506395
Hepatosplenomegaly 27.17 14.01 46 111838 4614 42504837
Abnormal behaviour 27.15 14.01 18 111866 26433 42483018
Herpes zoster 27.13 14.01 185 111699 38692 42470759
Gait inability 27.08 14.01 13 111871 22820 42486631
Respiratory arrest 27.00 14.01 21 111863 28403 42481048
Chromosomal mutation 26.97 14.01 8 111876 31 42509420
Treatment failure 26.93 14.01 267 111617 62357 42447094
Hepatosplenic candidiasis 26.93 14.01 13 111871 228 42509223
Cerebral aspergillosis 26.85 14.01 28 111856 1749 42507702
Disseminated cryptococcosis 26.73 14.01 29 111855 1896 42507555
Colitis ulcerative 26.61 14.01 18 111866 26157 42483294
Ureteric compression 26.60 14.01 14 111870 297 42509154
Pneumoperitoneum 26.55 14.01 32 111852 2346 42507105
Proctalgia 26.53 14.01 58 111826 7035 42502416
Benign prostatic hyperplasia 26.52 14.01 11 111873 21041 42488410
Plasmablastic lymphoma 26.50 14.01 18 111866 617 42508834
Dyskinesia 26.44 14.01 17 111867 25373 42484078
Extravasation 26.42 14.01 32 111852 2358 42507093
Haemoglobin abnormal 26.33 14.01 47 111837 4917 42504534
Rhabdomyosarcoma recurrent 26.31 14.01 11 111873 135 42509316
Tidal volume decreased 26.20 14.01 8 111876 35 42509416
Abdominal injury 25.96 14.01 9 111875 63 42509388
Oesophageal candidiasis 25.69 14.01 50 111834 5585 42503866
Delusion 25.61 14.01 4 111880 14730 42494721
Ototoxicity 25.49 14.01 31 111853 2294 42507157
Palpitations 25.45 14.01 60 111824 50737 42458714
Meningitis tuberculous 25.41 14.01 18 111866 661 42508790
Nasal congestion 25.34 14.01 24 111860 29477 42479974
Rectal haemorrhage 25.33 14.01 58 111826 49548 42459903
Mucormycosis 25.13 14.01 57 111827 7086 42502365
Cataract 25.02 14.01 26 111858 30578 42478873
Diabetes mellitus inadequate control 24.96 14.01 5 111879 15385 42494066
Cerebral candidiasis 24.92 14.01 9 111875 72 42509379
Systemic mycosis 24.83 14.01 31 111853 2356 42507095
Biliary-bronchial fistula 24.73 14.01 5 111879 0 42509451
Arrhythmogenic right ventricular dysplasia 24.70 14.01 8 111876 44 42509407
Nervous system disorder 24.70 14.01 100 111784 17095 42492356
Pneumonia viral 24.66 14.01 42 111842 4232 42505219
Diabetic ketoacidosis 24.65 14.01 14 111870 22353 42487098
Post-acute COVID-19 syndrome 24.65 14.01 15 111869 424 42509027
Deep vein thrombosis 24.39 14.01 309 111575 76648 42432803
Cytomegalovirus hepatitis 24.39 14.01 16 111868 517 42508934
Adverse event 24.38 14.01 16 111868 23624 42485827
Babesiosis 24.38 14.01 12 111872 220 42509231
Musculoskeletal pain 24.36 14.01 31 111853 33309 42476142
Flagellate dermatitis 24.34 14.01 10 111874 117 42509334
Impaired quality of life 24.30 14.01 4 111880 14173 42495278
Neurofibrosarcoma 24.12 14.01 8 111876 48 42509403
Intestinal atresia 24.00 14.01 9 111875 81 42509370
Iron deficiency anaemia 23.93 14.01 3 111881 13036 42496415
Herpes simplex encephalitis 23.84 14.01 14 111870 370 42509081
Hepatic enzyme increased 23.81 14.01 53 111831 45731 42463720
Lower respiratory tract infection 23.72 14.01 45 111839 41161 42468290
Vaccination failure 23.70 14.01 24 111860 1448 42508003
Prescribed overdose 23.66 14.01 3 111881 12924 42496527
Speech disorder 23.51 14.01 25 111859 29096 42480355
Corynebacterium infection 23.29 14.01 19 111865 864 42508587
Enterocolitis 23.28 14.01 68 111816 9861 42499590
Encephalitis enteroviral 23.20 14.01 11 111873 185 42509266
Injury 23.15 14.01 15 111869 22301 42487150
Arteriosclerosis coronary artery 23.14 14.01 10 111874 18667 42490784
Photosensitivity reaction 23.12 14.01 3 111881 12699 42496752
Acute lymphocytic leukaemia refractory 23.07 14.01 10 111874 135 42509316
Renal tubular disorder 22.92 14.01 44 111840 4865 42504586
B-cell lymphoma 22.90 14.01 44 111840 4869 42504582
Cutaneous T-cell lymphoma recurrent 22.83 14.01 8 111876 58 42509393
Hepatitis 22.81 14.01 136 111748 27164 42482287
Device issue 22.74 14.01 4 111880 13505 42495946
Disorder of orbit 22.73 14.01 9 111875 95 42509356
Cancer fatigue 22.73 14.01 11 111873 194 42509257
Haematoma 22.69 14.01 24 111860 27999 42481452
Hip fracture 22.65 14.01 4 111880 13468 42495983
Full blood count abnormal 22.65 14.01 27 111857 29849 42479602
Metastases to retroperitoneum 22.58 14.01 12 111872 260 42509191
Leukaemia 22.50 14.01 48 111836 5724 42503727
Abdominal wound dehiscence 22.43 14.01 10 111874 145 42509306
Abdominal lymphadenopathy 22.41 14.01 20 111864 1029 42508422
Enterococcal infection 22.30 14.01 76 111808 11963 42497488
Herpes virus infection 22.26 14.01 37 111847 3655 42505796
Dyspnoea exertional 22.24 14.01 63 111821 50085 42459366
Hepatitis viral 22.21 14.01 18 111866 811 42508640
Drug clearance decreased 22.20 14.01 28 111856 2150 42507301
Renal disorder 22.17 14.01 26 111858 28954 42480497
Metastases to chest wall 22.13 14.01 12 111872 271 42509180
Combined immunodeficiency 22.01 14.01 9 111875 104 42509347
Parasitic gastroenteritis 21.94 14.01 10 111874 153 42509298
Skin laceration 21.91 14.01 5 111879 14053 42495398
Decreased appetite 21.82 14.01 366 111518 192771 42316680
Respiratory moniliasis 21.78 14.01 12 111872 280 42509171
Clostridium difficile infection 21.65 14.01 117 111767 22542 42486909
Gout 21.65 14.01 25 111859 28030 42481421
Hyperlipidaemia 21.60 14.01 15 111869 21501 42487950
Metastases to bone marrow 21.51 14.01 15 111869 537 42508914
Therapeutic product effect decreased 21.46 14.01 44 111840 39106 42470345
Plasma cell myeloma recurrent 21.44 14.01 47 111837 5710 42503741
Retinopathy haemorrhagic 21.43 14.01 8 111876 71 42509380
Dyspepsia 21.40 14.01 48 111836 41304 42468147
Prostate cancer 21.37 14.01 54 111830 44589 42464862
Subclavian vein thrombosis 21.30 14.01 19 111865 977 42508474
Eye pain 21.29 14.01 9 111875 17021 42492430
Norovirus infection 21.28 14.01 17 111867 750 42508701
Hypersomnia 21.24 14.01 6 111878 14612 42494839
Cardiomyopathy acute 21.14 14.01 8 111876 74 42509377
Mucosal toxicity 21.11 14.01 12 111872 298 42509153
Flatulence 20.98 14.01 21 111863 25131 42484320
Bacterial sepsis 20.92 14.01 50 111834 6432 42503019
Transplant rejection 20.85 14.01 5 111879 13583 42495868
Phlebitis infective 20.79 14.01 9 111875 121 42509330
Body temperature decreased 20.79 14.01 6 111878 14407 42495044
Vena cava thrombosis 20.78 14.01 23 111861 1538 42507913
Sphingomonas paucimobilis infection 20.70 14.01 7 111877 45 42509406
Metastases to muscle 20.63 14.01 11 111873 240 42509211
West Nile viral infection 20.62 14.01 18 111866 899 42508552
Pneumonia respiratory syncytial viral 20.61 14.01 22 111862 1412 42508039
Gastrointestinal protozoal infection 20.59 14.01 8 111876 80 42509371
Limb injury 20.55 14.01 6 111878 14299 42495152
Ageusia 20.51 14.01 3 111881 11602 42497849
Acute hepatic failure 20.45 14.01 94 111790 16979 42492472
Bronchitis 20.41 14.01 60 111824 47141 42462310
Helicobacter sepsis 20.28 14.01 6 111878 23 42509428
Anaphylactic reaction 20.23 14.01 52 111832 42691 42466760
Abdominal mass 20.20 14.01 28 111856 2358 42507093
Dementia 20.14 14.01 9 111875 16471 42492980
Pathogen resistance 20.10 14.01 71 111813 11379 42498072
Ventricular tachycardia 20.07 14.01 30 111854 30130 42479321
Cholelithiasis 20.04 14.01 19 111865 23327 42486124
Testicular disorder 20.04 14.01 18 111866 934 42508517
Sopor 19.98 14.01 5 111879 13197 42496254
Liver function test abnormal 19.88 14.01 34 111850 32357 42477094
Taeniasis 19.83 14.01 7 111877 52 42509399
Neck pain 19.83 14.01 30 111854 29984 42479467
Refractory anaemia with an excess of blasts 19.69 14.01 12 111872 340 42509111
Chronic lymphocytic leukaemia refractory 19.68 14.01 8 111876 91 42509360
Blister 19.63 14.01 26 111858 27464 42481987
Candida endophthalmitis 19.62 14.01 9 111875 140 42509311
Premature ageing 19.60 14.01 8 111876 92 42509359
Plasma cell leukaemia 19.57 14.01 20 111864 1220 42508231
Epstein-Barr virus infection reactivation 19.55 14.01 29 111855 2598 42506853
Angiocentric lymphoma 19.55 14.01 14 111870 523 42508928
Molluscum contagiosum 19.54 14.01 12 111872 345 42509106
Positron emission tomogram abnormal 19.53 14.01 10 111874 200 42509251
Salivary gland neoplasm 19.51 14.01 6 111878 27 42509424
Cellulitis gangrenous 19.46 14.01 11 111873 270 42509181
Viral load increased 19.38 14.01 31 111853 2966 42506485
Gastroenteritis adenovirus 19.31 14.01 10 111874 205 42509246
Mucoepidermoid carcinoma of salivary gland 19.26 14.01 5 111879 10 42509441
Hernia 19.26 14.01 3 111881 11070 42498381
Enterococcal bacteraemia 19.22 14.01 29 111855 2638 42506813
Feeling hot 19.14 14.01 20 111864 23462 42485989
Lymphocytosis 19.12 14.01 31 111853 3000 42506451
Peritoneal lesion 19.11 14.01 9 111875 149 42509302
Ear infection 19.09 14.01 5 111879 12799 42496652
Coronary artery occlusion 19.08 14.01 3 111881 10994 42498457
Ocular hyperaemia 19.07 14.01 9 111875 15954 42493497
Adenocarcinoma gastric 19.06 14.01 21 111863 1397 42508054
Spindle cell sarcoma 19.00 14.01 9 111875 151 42509300
Splenic marginal zone lymphoma 19 14.01 6 111878 30 42509421
Urethral obstruction 18.88 14.01 10 111874 215 42509236
Candida pneumonia 18.84 14.01 16 111868 770 42508681
Human polyomavirus infection 18.74 14.01 20 111864 1283 42508168
Tracheal fistula 18.74 14.01 9 111875 156 42509295
Anisocytosis 18.74 14.01 14 111870 559 42508892
Hepatic amoebiasis 18.66 14.01 7 111877 63 42509388
Hypertransaminasaemia 18.65 14.01 60 111824 9167 42500284
Pneumonia aspiration 18.65 14.01 68 111816 50010 42459441
Blood urine present 18.64 14.01 4 111880 11729 42497722
Premature baby 18.49 14.01 114 111770 23039 42486412
B-cell type acute leukaemia 18.45 14.01 16 111868 792 42508659
Drug eruption 18.42 14.01 20 111864 23055 42486396
Febrile infection 18.38 14.01 29 111855 2742 42506709
Bladder cancer 18.32 14.01 11 111873 17036 42492415
Hyponatraemia 18.31 14.01 174 111710 101288 42408163
Asthenospermia 18.29 14.01 7 111877 67 42509384
Sarcoma metastatic 18.29 14.01 7 111877 67 42509384
Haematemesis 18.26 14.01 32 111852 30167 42479284
Joint stiffness 18.01 14.01 5 111879 12317 42497134
Movement disorder 18 14.01 8 111876 14690 42494761
Peripheral nerve injury 17.95 14.01 11 111873 315 42509136
Acute hepatitis B 17.89 14.01 10 111874 240 42509211
Cytomegalovirus colitis 17.76 14.01 35 111849 3946 42505505
Disease susceptibility 17.67 14.01 7 111877 74 42509377
Blood creatinine increased 17.64 14.01 194 111690 109809 42399642
Hepatic angiosarcoma 17.59 14.01 7 111877 75 42509376
Blastic plasmacytoid dendritic cell neoplasia 17.59 14.01 7 111877 75 42509376
Morphoea 17.56 14.01 10 111874 249 42509202
Facial paresis 17.53 14.01 31 111853 3219 42506232
Bacillus infection 17.50 14.01 15 111869 731 42508720
Activated partial thromboplastin time prolonged 17.46 14.01 10 111874 15893 42493558
Bacillus bacteraemia 17.45 14.01 9 111875 183 42509268
Muscle rigidity 17.43 14.01 5 111879 12054 42497397
Metastases to testicle 17.43 14.01 7 111877 77 42509374
Acne 17.39 14.01 7 111877 13637 42495814
Streptococcal bacteraemia 17.39 14.01 28 111856 2694 42506757
Hepatic infection fungal 17.32 14.01 10 111874 256 42509195
Natural killer-cell lymphoblastic lymphoma 17.31 14.01 6 111878 42 42509409
Product storage error 17.29 14.01 4 111880 11136 42498315
Guillain-Barre syndrome 17.28 14.01 50 111834 7213 42502238
Rhinorrhoea 17.20 14.01 36 111848 31758 42477693
Genotoxicity 17.18 14.01 6 111878 43 42509408
Periorbital infection 17.14 14.01 9 111875 190 42509261
Acute lung injury 17.12 14.01 21 111863 1568 42507883
Panic attack 17.07 14.01 4 111880 11041 42498410
Candida sepsis 17.05 14.01 20 111864 1425 42508026
Anaplastic large-cell lymphoma 17.03 14.01 7 111877 82 42509369
Acute pulmonary histoplasmosis 17.02 14.01 9 111875 193 42509258
Localised infection 17.00 14.01 17 111867 20356 42489095
Vasculitis 16.96 14.01 14 111870 18380 42491071
Paternal exposure timing unspecified 16.95 14.01 6 111878 45 42509406
Muscular weakness 16.91 14.01 139 111745 83359 42426092
Retroperitoneal lymphadenopathy 16.91 14.01 17 111867 1017 42508434
Escherichia test positive 16.79 14.01 19 111865 1302 42508149
Splenic candidiasis 16.74 14.01 7 111877 86 42509365
Hyperbilirubinaemia 16.73 14.01 102 111782 20533 42488918
Nodular regenerative hyperplasia 16.71 14.01 17 111867 1031 42508420
Disseminated cytomegaloviral infection 16.68 14.01 10 111874 275 42509176
Spinal cord ischaemia 16.66 14.01 7 111877 87 42509364
Rash macular 16.66 14.01 12 111872 16879 42492572
Pulmonary sarcoidosis 16.59 14.01 15 111869 785 42508666
Hypoalbuminaemia 16.57 14.01 83 111801 15527 42493924
Tumour necrosis 16.55 14.01 21 111863 1623 42507828
Angioimmunoblastic T-cell lymphoma recurrent 16.54 14.01 5 111879 21 42509430
Myasthenia gravis 16.53 14.01 11 111873 16126 42493325
Cerebral haemorrhage 16.51 14.01 50 111834 38916 42470535
Influenza like illness 16.44 14.01 37 111847 31803 42477648
Cardiomegaly 16.42 14.01 12 111872 16754 42492697
Ileus 16.41 14.01 96 111788 19043 42490408
Ileal perforation 16.40 14.01 17 111867 1054 42508397
Ventricular fibrillation 16.39 14.01 34 111850 30089 42479362
Anaplastic large cell lymphoma T- and null-cell types 16.39 14.01 8 111876 144 42509307
Granulocytopenia neonatal 16.35 14.01 5 111879 22 42509429
Device related infection 16.29 14.01 100 111784 20179 42489272
Venous thrombosis 16.25 14.01 34 111850 4001 42505450
Underdose 16.23 14.01 12 111872 16654 42492797
Hepatitis B DNA increased 16.23 14.01 13 111871 576 42508875
Palmar-plantar erythrodysaesthesia syndrome 16.22 14.01 101 111783 20481 42488970
Peripheral blood stem cell apheresis 16.19 14.01 8 111876 148 42509303
Leiomyosarcoma metastatic 16.13 14.01 4 111880 6 42509445
Chronic lymphocytic leukaemia transformation 16.07 14.01 9 111875 217 42509234
Superior vena cava syndrome 16.01 14.01 14 111870 701 42508750
Disseminated blastomycosis 15.94 14.01 11 111873 387 42509064
Altered state of consciousness 15.94 14.01 33 111851 29226 42480225
Urinary retention 15.93 14.01 57 111827 42157 42467294
Dysaesthesia 15.92 14.01 26 111858 2531 42506920
Cold sweat 15.83 14.01 5 111879 11325 42498126
Mental status changes 15.81 14.01 57 111827 42058 42467393
Seizure 15.80 14.01 222 111662 120339 42389112
Oligohydramnios 15.77 14.01 11 111873 394 42509057
Hypercholesterolaemia 15.73 14.01 7 111877 12842 42496609
Thrombophlebitis 15.71 14.01 33 111851 3893 42505558
Dystonia 15.60 14.01 7 111877 12783 42496668
Infusion site discolouration 15.60 14.01 9 111875 230 42509221
Catheter site thrombosis 15.58 14.01 8 111876 161 42509290
Hyperleukocytosis 15.54 14.01 26 111858 2582 42506869
Paraesthesia 15.47 14.01 121 111763 73338 42436113
Cerebral infarction 15.47 14.01 37 111847 31132 42478319
Focal nodular hyperplasia 15.45 14.01 8 111876 164 42509287
Plasma cells decreased 15.44 14.01 6 111878 60 42509391
Appendiceal abscess 15.43 14.01 7 111877 106 42509345
Enterovirus infection 15.43 14.01 18 111866 1275 42508176
T-cell lymphoma 15.37 14.01 17 111867 1136 42508315
Dry eye 15.32 14.01 11 111873 15495 42493956
Wound evisceration 15.31 14.01 7 111877 108 42509343
Rash maculo-papular 15.27 14.01 49 111835 37454 42471997
Acute respiratory distress syndrome 15.27 14.01 133 111751 29975 42479476
Fusarium infection 15.26 14.01 20 111864 1596 42507855
Metastases to eye 15.25 14.01 7 111877 109 42509342
Suspected product quality issue 15.22 14.01 9 111875 241 42509210
Congenital hepatobiliary anomaly 15.22 14.01 5 111879 29 42509422
Neuroborreliosis 15.18 14.01 6 111878 63 42509388
Embolism 15.09 14.01 54 111830 8709 42500742
Hyperfibrinogenaemia 15.08 14.01 7 111877 112 42509339
Adrenocortical carcinoma 15.08 14.01 5 111879 30 42509421
Epistaxis 15.06 14.01 108 111776 66718 42442733
Neurological examination abnormal 14.95 14.01 10 111874 334 42509117
Meningitis aseptic 14.92 14.01 35 111849 4447 42505004
Administration site injury 14.84 14.01 3 111881 0 42509451
Carnitine deficiency 14.80 14.01 7 111877 117 42509334
Diffuse large B-cell lymphoma stage IV 14.80 14.01 12 111872 541 42508910
Escherichia bacteraemia 14.80 14.01 38 111846 5111 42504340
DNA mismatch repair protein gene mutation 14.80 14.01 4 111880 10 42509441
Device related sepsis 14.78 14.01 32 111852 3855 42505596
Haematuria 14.74 14.01 90 111794 57709 42451742
Therapy responder 14.70 14.01 8 111876 182 42509269
Skin discolouration 14.67 14.01 20 111864 20870 42488581
Germ cell cancer 14.64 14.01 7 111877 120 42509331
Retroperitoneal mass 14.64 14.01 7 111877 120 42509331
Mastitis 14.62 14.01 8 111876 184 42509267
Orthostatic hypotension 14.61 14.01 37 111847 30533 42478918
Throat irritation 14.60 14.01 8 111876 13028 42496423
Colon neoplasm 14.59 14.01 12 111872 552 42508899
Cholangitis 14.52 14.01 5 111879 10722 42498729
Metastases to skin 14.52 14.01 12 111872 556 42508895
Myocarditis 14.48 14.01 17 111867 18921 42490530
Pneumonia salmonella 14.47 14.01 6 111878 72 42509379
Disseminated toxoplasmosis 14.43 14.01 9 111875 266 42509185
Adrenal insufficiency 14.38 14.01 92 111792 18832 42490619
Hepatitis acute 14.38 14.01 3 111881 8972 42500479
Organising pneumonia 14.35 14.01 48 111836 7484 42501967
Cystitis viral 14.34 14.01 17 111867 1225 42508226
Neuroendocrine carcinoma of the skin 14.32 14.01 15 111869 942 42508509
Oedema 14.31 14.01 79 111805 51922 42457529
T-cell lymphoma refractory 14.30 14.01 5 111879 36 42509415
IIIrd nerve paresis 14.29 14.01 7 111877 127 42509324
Rales 14.29 14.01 6 111878 11394 42498057
Peripheral T-cell lymphoma unspecified refractory 14.27 14.01 4 111880 12 42509439
Metapneumovirus bronchiolitis 14.27 14.01 4 111880 12 42509439
Depressed level of consciousness 14.26 14.01 71 111813 47899 42461552
Food protein-induced enterocolitis syndrome 14.18 14.01 5 111879 37 42509414
Angiosarcoma 14.17 14.01 10 111874 365 42509086
Jugular vein thrombosis 14.17 14.01 22 111862 2052 42507399
Breath sounds abnormal 14.17 14.01 7 111877 12086 42497365
Impaired work ability 14.16 14.01 7 111877 12084 42497367
Metabolic acidosis 14.16 14.01 79 111805 51779 42457672

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 11929.29 12.90 7579 215027 309188 110057505
Disease progression 4901.39 12.90 3997 218609 240037 110126656
Neutropenia 4752.51 12.90 4734 217872 369886 109996807
Acute myeloid leukaemia 1948.49 12.90 1115 221491 36995 110329698
Mucosal inflammation 1933.41 12.90 1579 221027 94562 110272131
Cardiotoxicity 1800.41 12.90 812 221794 16069 110350624
Haematotoxicity 1672.85 12.90 827 221779 20255 110346438
Pancytopenia 1639.14 12.90 2063 220543 207550 110159143
Second primary malignancy 1621.19 12.90 771 221835 17297 110349396
Myelodysplastic syndrome 1592.12 12.90 973 221633 36511 110330182
Thrombocytopenia 1589.39 12.90 2657 219949 346228 110020465
Off label use 1493.20 12.90 6452 216154 1493733 108872960
Diffuse large B-cell lymphoma recurrent 1476.68 12.90 534 222072 5765 110360928
Myelosuppression 1436.01 12.90 1322 221284 93018 110273675
Malignant neoplasm progression 1296.15 12.90 1675 220931 172892 110193801
Bone marrow failure 1103.66 12.90 922 221684 56926 110309767
Neoplasm progression 1058.91 12.90 944 221662 63651 110303042
Tumour lysis syndrome 982.77 12.90 668 221938 30133 110336560
Hepatitis B reactivation 979.85 12.90 416 222190 7068 110359625
Neuropathy peripheral 928.82 12.90 1449 221157 177828 110188865
Septic shock 903.49 12.90 1335 221271 156193 110210500
Cardiomyopathy 899.65 12.90 654 221952 32871 110333822
Product use in unapproved indication 887.99 12.90 2430 220176 444947 109921746
Febrile bone marrow aplasia 876.37 12.90 505 222101 16960 110349733
Therapy partial responder 869.55 12.90 667 221939 36394 110330299
Leukopenia 856.21 12.90 1263 221343 147528 110219165
Pneumocystis jirovecii pneumonia 841.84 12.90 694 221912 42041 110324652
Anaemia 819.41 12.90 2690 219916 544396 109822297
Cytokine release syndrome 796.84 12.90 839 221767 69467 110297226
Joint swelling 771.67 12.90 27 222579 442818 109923875
Sepsis 762.84 12.90 1889 220717 325457 110041236
Hepatitis B 759.23 12.90 376 222230 9236 110357457
Ejection fraction decreased 755.79 12.90 640 221966 40240 110326453
Cytopenia 721.86 12.90 549 222057 29567 110337126
Disease recurrence 688.14 12.90 725 221881 60059 110306634
Arthralgia 667.96 12.90 370 222236 779262 109587431
Neutropenic sepsis 632.19 12.90 512 222094 30234 110336459
Interstitial lung disease 628.52 12.90 1058 221548 138276 110228417
Neutrophil count decreased 614.19 12.90 969 221637 119972 110246721
Pain 574.40 12.90 647 221959 954308 109412385
Pyrexia 568.61 12.90 3412 219194 894853 109471840
Fall 563.77 12.90 255 222351 603227 109763466
Rheumatoid arthritis 548.84 12.90 11 222595 299602 110067091
Synovitis 519.26 12.90 6 222600 274086 110092607
Peripheral swelling 515.46 12.90 95 222511 403939 109962754
Drug hypersensitivity 496.08 12.90 149 222457 453941 109912752
Systemic lupus erythematosus 494.12 12.90 3 222603 254335 110112358
Nasopharyngitis 481.55 12.90 103 222503 394258 109972435
Abdominal discomfort 478.63 12.90 104 222502 393754 109972939
Cardiac failure 476.42 12.90 1120 221486 186506 110180187
Product dose omission issue 467.90 12.90 51 222555 321731 110044962
Headache 460.63 12.90 665 221941 881712 109484981
Pruritus 458.45 12.90 304 222302 581256 109785437
Arthropathy 457.70 12.90 31 222575 287491 110079202
Progressive multifocal leukoencephalopathy 449.56 12.90 385 222221 24571 110342122
Weight increased 441.76 12.90 147 222459 419497 109947196
Posterior reversible encephalopathy syndrome 439.74 12.90 435 222171 33426 110333267
Musculoskeletal stiffness 431.64 12.90 35 222571 279787 110086906
Swelling 421.83 12.90 95 222511 350946 110015747
Pemphigus 409.59 12.90 4 222602 214566 110152127
Rash 404.89 12.90 643 221963 820321 109546372
Blood lactate dehydrogenase increased 393.79 12.90 466 222140 43868 110322825
Dizziness 378.21 12.90 512 222094 697681 109669012
Glossodynia 378.02 12.90 16 222590 221988 110144705
Wound 376.86 12.90 24 222582 234413 110132280
Diffuse large B-cell lymphoma refractory 376.68 12.90 154 222452 2367 110364326
Left ventricular dysfunction 366.40 12.90 334 222272 23159 110343534
Psoriatic arthropathy 365.27 12.90 6 222600 196755 110169938
Wheezing 359.67 12.90 45 222561 255185 110111508
Asthma 353.02 12.90 44 222562 250247 110116446
Urticaria 351.04 12.90 103 222503 318754 110047939
Insomnia 346.45 12.90 146 222460 360444 110006249
Lymphadenopathy 341.39 12.90 524 222082 63311 110303382
Congestive cardiomyopathy 333.64 12.90 256 222350 13963 110352730
Neurotoxicity 331.62 12.90 417 222189 41790 110324903
Contusion 331.62 12.90 40 222566 233321 110133372
Palmar-plantar erythrodysaesthesia syndrome 329.80 12.90 410 222196 40615 110326078
Anxiety 329.46 12.90 141 222465 344937 110021756
White blood cell count decreased 327.16 12.90 1111 221495 228279 110138414
Blood cholesterol increased 326.09 12.90 10 222596 184775 110181918
Hypogammaglobulinaemia 324.05 12.90 291 222315 19785 110346908
Contraindicated product administered 323.81 12.90 55 222551 248212 110118481
Fibromyalgia 322.47 12.90 4 222602 170905 110195788
Multiple organ dysfunction syndrome 320.04 12.90 844 221762 150866 110215827
Muscle spasms 317.07 12.90 84 222522 278073 110088620
Pain in extremity 313.41 12.90 311 222295 486807 109879886
Haemophagocytic lymphohistiocytosis 312.69 12.90 351 222255 31208 110335485
Metastases to bone 312.69 12.90 350 222256 31022 110335671
B-cell lymphoma recurrent 308.63 12.90 108 222498 1050 110365643
Therapeutic product effect decreased 303.89 12.90 61 222545 244255 110122438
Polyneuropathy 301.84 12.90 347 222259 31665 110335028
Cytomegalovirus chorioretinitis 299.86 12.90 184 222422 6944 110359749
Drug abuse 298.03 12.90 14 222592 177397 110189296
Irritable bowel syndrome 296.80 12.90 7 222599 164208 110202485
Mobility decreased 293.80 12.90 60 222546 237362 110129331
Helicobacter infection 285.34 12.90 21 222585 181856 110184837
Ventricular dysfunction 283.52 12.90 181 222425 7330 110359363
Metastases to lung 282.37 12.90 287 222319 22776 110343917
Hepatic enzyme increased 281.89 12.90 147 222459 320745 110045948
Neutropenic colitis 279.02 12.90 184 222422 7881 110358812
Osteoarthritis 278.37 12.90 24 222582 182599 110184094
Agranulocytosis 271.69 12.90 464 222142 61296 110305397
Malaise 270.10 12.90 595 222011 671224 109695469
Blood pressure increased 269.13 12.90 92 222514 258281 110108412
Depression 269.08 12.90 152 222454 317183 110049510
Injury 265.61 12.90 25 222581 177240 110189453
Acquired gene mutation 263.82 12.90 123 222483 2631 110364062
Diffuse large B-cell lymphoma 263.65 12.90 234 222372 15664 110351029
Respiratory failure 262.65 12.90 991 221615 214341 110152352
Discomfort 258.01 12.90 58 222548 214649 110152044
Pneumonitis 257.28 12.90 512 222094 76019 110290674
Sinusitis 253.14 12.90 141 222465 296547 110070146
Neoplasm recurrence 248.44 12.90 146 222460 5086 110361607
Impaired healing 246.96 12.90 48 222558 196669 110170024
Sleep disorder 246.17 12.90 50 222556 198594 110168099
Intentional overdose 246.07 12.90 4 222602 132497 110234196
Platelet count decreased 245.92 12.90 1017 221589 229426 110137267
Type 2 diabetes mellitus 245.43 12.90 33 222573 177199 110189494
Injection site pain 241.98 12.90 35 222571 177887 110188806
Overdose 238.77 12.90 86 222520 233708 110132985
Bursitis 236.88 12.90 5 222601 129913 110236780
Blister 235.01 12.90 82 222524 227294 110139399
Folliculitis 232.67 12.90 31 222575 167622 110199071
Metastases to liver 230.64 12.90 319 222287 35067 110331626
Psoriasis 228.96 12.90 13 222593 139980 110226713
Intentional product misuse 224.81 12.90 10 222596 132894 110233799
Drug ineffective 223.32 12.90 4292 218314 1516248 108850445
Lower respiratory tract infection 223.08 12.90 105 222501 243001 110123692
Peripheral sensory neuropathy 221.60 12.90 217 222389 16463 110350230
Dry mouth 221.05 12.90 64 222542 199884 110166809
Fatigue 218.15 12.90 1494 221112 1214464 109152229
Joint range of motion decreased 217.10 12.90 6 222600 121826 110244867
Epstein-Barr virus infection 216.43 12.90 226 222380 18512 110348181
Pleural effusion 215.96 12.90 817 221789 176892 110189801
Cystitis haemorrhagic 213.08 12.90 185 222421 12024 110354669
Aspergillus infection 210.69 12.90 259 222347 25357 110341336
Candida infection 210.24 12.90 360 222246 47649 110319044
Musculoskeletal pain 207.13 12.90 56 222550 182967 110183726
Abdominal pain upper 206.45 12.90 239 222367 348872 110017821
Confusional state 205.19 12.90 395 222211 468285 109898408
Somnolence 202.80 12.90 180 222426 297269 110069424
Arthritis 201.88 12.90 45 222561 167541 110199152
Feeling abnormal 201.32 12.90 57 222549 180654 110186039
Pericarditis 198.94 12.90 96 222510 219018 110147675
Bacteraemia 197.77 12.90 327 222279 42063 110324630
Bronchopulmonary aspergillosis 197.32 12.90 271 222335 29592 110337101
Venoocclusive liver disease 194.90 12.90 194 222412 15013 110351680
Mantle cell lymphoma recurrent 192.91 12.90 74 222532 952 110365741
Post transplant lymphoproliferative disorder 192.42 12.90 195 222411 15418 110351275
Intestinal perforation 192.36 12.90 224 222382 20720 110345973
Drug resistance 189.28 12.90 377 222229 55997 110310696
Lymphopenia 187.58 12.90 310 222296 39860 110326833
Aplasia 187.46 12.90 143 222463 7730 110358963
Lip dry 185.93 12.90 3 222603 100080 110266613
Road traffic accident 185.27 12.90 7 222599 107391 110259302
Cytomegalovirus infection 185.09 12.90 366 222240 54078 110312615
Metastases to lymph nodes 183.91 12.90 187 222419 14845 110351848
COVID-19 183.81 12.90 976 221630 244084 110122609
Loss of personal independence in daily activities 179.26 12.90 41 222565 149979 110216714
Immune effector cell-associated neurotoxicity syndrome 179.23 12.90 183 222423 14599 110352094
Hospitalisation 176.25 12.90 36 222570 142457 110224236
Acute promyelocytic leukaemia 173.36 12.90 82 222524 1814 110364879
Bone marrow disorder 172.52 12.90 107 222499 4116 110362577
C-reactive protein abnormal 168.46 12.90 29 222577 129666 110237027
Memory impairment 165.92 12.90 95 222511 196849 110169844
Hypoaesthesia 164.20 12.90 236 222370 313987 110052706
Hypersensitivity 162.78 12.90 357 222249 403641 109963052
Inappropriate schedule of product administration 160.75 12.90 106 222500 203531 110163162
Drug intolerance 160.70 12.90 363 222243 406149 109960544
Systemic candida 159.83 12.90 144 222462 9830 110356863
Myelopathy 159.20 12.90 113 222493 5463 110361230
Hepatic failure 158.92 12.90 396 222210 68343 110298350
Gait inability 157.59 12.90 40 222566 136336 110230357
Staphylococcal bacteraemia 157.49 12.90 181 222425 16507 110350186
Prescribed overdose 157.22 12.90 4 222602 87577 110279116
Metastasis 155.97 12.90 131 222475 8136 110358557
Gene mutation 155.79 12.90 93 222513 3336 110363357
Migraine 154.60 12.90 76 222530 171576 110195117
Cardiac dysfunction 152.52 12.90 115 222491 6108 110360585
Gastrooesophageal reflux disease 148.51 12.90 89 222517 179887 110186806
Gait disturbance 147.28 12.90 207 222399 278001 110088692
Lymphoma 146.96 12.90 192 222414 19979 110346714
Gastrointestinal toxicity 146.17 12.90 144 222462 11004 110355689
Hypercholesterolaemia 143.85 12.90 10 222596 90827 110275866
Breast cancer metastatic 142.11 12.90 142 222464 11039 110355654
Drug interaction 141.14 12.90 524 222082 499659 109867034
Anti-Muellerian hormone level decreased 140.89 12.90 35 222571 80 110366613
Stress 140.29 12.90 22 222584 105326 110261367
Bone pain 139.95 12.90 365 222241 64768 110301925
Hepatotoxicity 137.98 12.90 357 222249 63043 110303650
Bronchitis 137.71 12.90 72 222534 156960 110209733
Cytomegalovirus infection reactivation 137.46 12.90 177 222429 18156 110348537
Peripheral venous disease 136.96 12.90 8 222598 84109 110282584
Inflammation 135.23 12.90 114 222492 193124 110173569
Rhabdomyolysis 132.20 12.90 39 222567 120362 110246331
Administration site extravasation 131.70 12.90 66 222540 1663 110365030
Klebsiella infection 131.32 12.90 181 222425 19828 110346865
Suicide attempt 130.22 12.90 25 222581 103369 110263324
Lymphoma transformation 129.66 12.90 48 222558 556 110366137
Injection site erythema 129.26 12.90 18 222588 94158 110272535
Myeloid leukaemia 127.47 12.90 53 222553 852 110365841
Injection site reaction 127.14 12.90 15 222591 89055 110277638
Sciatica 126.02 12.90 18 222588 92381 110274312
Metastases to central nervous system 125.76 12.90 190 222416 22627 110344066
COVID-19 pneumonia 125.41 12.90 249 222357 36894 110329799
Herpes simplex 124.20 12.90 156 222450 15608 110351085
Pneumonia 123.95 12.90 2463 220143 874251 109492442
Grip strength decreased 123.62 12.90 10 222596 80164 110286529
Heart rate decreased 123.07 12.90 12 222594 82744 110283949
Acute lymphocytic leukaemia recurrent 122.38 12.90 98 222508 5689 110361004
Pneumonia fungal 119.44 12.90 148 222458 14606 110352087
Venoocclusive disease 118.51 12.90 100 222506 6250 110360443
Myocardial infarction 117.30 12.90 128 222478 191955 110174738
Incorrect dose administered 116.70 12.90 32 222574 103609 110263084
Central nervous system lymphoma 116.50 12.90 74 222532 2970 110363723
Pulmonary toxicity 115.67 12.90 160 222446 17586 110349107
Alopecia 115.12 12.90 364 222242 364389 110002304
Oedema 114.36 12.90 153 222453 209823 110156870
Toxic cardiomyopathy 113.81 12.90 47 222559 742 110365951
Nephropathy toxic 113.72 12.90 201 222405 27277 110339416
Obesity 113.48 12.90 43 222563 113308 110253385
Chest pain 111.63 12.90 386 222220 375989 109990704
Metastases to skin 111.39 12.90 65 222541 2234 110364459
Hepatitis E 110.61 12.90 83 222523 4376 110362317
Ascites 110.46 12.90 424 222182 92384 110274309
Suicidal ideation 109.59 12.90 27 222579 93910 110272783
JC virus infection 108.51 12.90 88 222518 5202 110361491
Acute lymphocytic leukaemia 108.03 12.90 91 222515 5674 110361019
Joint stiffness 107.66 12.90 7 222599 67236 110299457
Breast cancer recurrent 107.64 12.90 77 222529 3769 110362924
Amnesia 107.18 12.90 39 222567 105369 110261324
Injection site swelling 106.66 12.90 4 222602 61786 110304907
Strongyloidiasis 106.65 12.90 85 222521 4901 110361792
Neck pain 105.69 12.90 58 222548 123072 110243621
Hypertension 105.37 12.90 599 222007 509485 109857208
Peripheral T-cell lymphoma unspecified 105.04 12.90 46 222560 845 110365848
Immune-mediated myocarditis 104.78 12.90 73 222533 3425 110363268
Wound infection 104.54 12.90 32 222574 96433 110270260
Tremor 104.50 12.90 153 222453 202079 110164614
Adverse drug reaction 104.09 12.90 41 222565 105518 110261175
Leukaemia 103.98 12.90 100 222506 7418 110359275
Enterococcal bacteraemia 103.96 12.90 80 222526 4381 110362312
Clostridium difficile colitis 103.07 12.90 254 222352 43524 110323169
Fluid retention 102.71 12.90 31 222575 94276 110272417
Frequent bowel movements 101.95 12.90 12 222594 71378 110295315
Enterococcal infection 101.64 12.90 162 222444 20204 110346489
Product quality issue 101 12.90 17 222589 77282 110289411
Osteonecrosis 100.72 12.90 215 222391 33526 110333167
Condition aggravated 100.47 12.90 970 221636 733866 109632827
Metastases to peritoneum 99.90 12.90 86 222520 5524 110361169
Computerised tomogram thorax abnormal 99.69 12.90 65 222541 2730 110363963
Traumatic lung injury 99.50 12.90 63 222543 2514 110364179
Dry skin 99.47 12.90 46 222560 107607 110259086
Visual impairment 99.44 12.90 75 222531 134353 110232340
Cerebrovascular accident 98.81 12.90 132 222474 181152 110185541
Blood pressure fluctuation 98.78 12.90 16 222590 74808 110291885
Autoimmune disorder 98.69 12.90 9 222597 65474 110301219
Adverse event 98.23 12.90 48 222558 108761 110257932
Malignant transformation 98.22 12.90 52 222554 1473 110365220
Bradycardia 97.89 12.90 101 222505 155416 110211277
Dyspnoea 97.81 12.90 1604 221002 1105268 109261425
Illness 97.07 12.90 23 222583 82148 110284545
Blood pressure systolic increased 96.53 12.90 24 222582 82967 110283726
Ventricular hypokinesia 96.47 12.90 116 222490 11098 110355595
Hypoglycaemia 96.35 12.90 57 222549 116047 110250646
Escherichia sepsis 96.23 12.90 111 222495 10161 110356532
Sweat gland tumour 95.90 12.90 38 222568 536 110366157
Prescribed underdose 95.48 12.90 10 222596 65164 110301529
Encephalopathy 95.39 12.90 369 222237 80686 110286007
Gastrosplenic fistula 94.63 12.90 27 222579 123 110366570
Dyspepsia 93.36 12.90 150 222456 190815 110175878
Salivary gland cancer 92.96 12.90 36 222570 476 110366217
Fanconi syndrome 92.89 12.90 68 222538 3451 110363242
Angioedema 92.71 12.90 41 222565 98459 110268234
Small intestinal obstruction 92.42 12.90 202 222404 32011 110334682
Heart rate increased 92.14 12.90 92 222514 143742 110222951
Myalgia 90.74 12.90 195 222411 222186 110144507
Plasmacytoma 90.34 12.90 79 222527 5183 110361510
Cardiomyopathy acute 89.86 12.90 33 222573 373 110366320
Pleuroparenchymal fibroelastosis 89.68 12.90 32 222574 331 110366362
Injection site pruritus 89.59 12.90 3 222603 51255 110315438
Nasal congestion 89.26 12.90 43 222563 98239 110268454
Escherichia bacteraemia 87.21 12.90 105 222501 10059 110356634
Escherichia infection 86.91 12.90 165 222441 23651 110343042
Red blood cell sedimentation rate increased 86.62 12.90 25 222581 78277 110288416
Ear infection 86.06 12.90 12 222594 62720 110303973
Staphylococcal sepsis 85.96 12.90 138 222468 17316 110349377
Chronic obstructive pulmonary disease 85.87 12.90 57 222549 109101 110257592
Skin toxicity 85.59 12.90 112 222494 11671 110355022
Colitis ulcerative 85.03 12.90 25 222581 77338 110289355
Organising pneumonia 84.82 12.90 123 222483 14120 110352573
Medication error 84.27 12.90 54 222552 105312 110261381
Maternal exposure during pregnancy 84.20 12.90 249 222357 254634 110112059
Infection reactivation 83.95 12.90 68 222538 4013 110362680
Pneumocystis jirovecii infection 83.58 12.90 70 222536 4330 110362363
Blood glucose increased 83.44 12.90 86 222520 132410 110234283
Thrombotic microangiopathy 81.60 12.90 181 222425 28968 110337725
Computerised tomogram thorax 81.56 12.90 33 222573 493 110366200
Oedema peripheral 80.89 12.90 363 222243 328297 110038396
BK virus infection 80.71 12.90 115 222491 12991 110353702
Epstein-Barr virus associated lymphoma 80.34 12.90 47 222559 1623 110365070
Injection site bruising 80.14 12.90 6 222600 51257 110315436
Neutrophil count abnormal 80.08 12.90 73 222533 5059 110361634
Peripheral motor neuropathy 79.68 12.90 66 222540 4020 110362673
Swollen tongue 79.48 12.90 13 222593 60349 110306344
Refractory anaemia with an excess of blasts 78.57 12.90 37 222569 810 110365883
Pneumatosis intestinalis 77.95 12.90 91 222515 8438 110358255
Hyperhidrosis 77.44 12.90 163 222443 187135 110179558
Nephrolithiasis 77.30 12.90 19 222587 66193 110300500
Glioma 76.91 12.90 37 222569 851 110365842
5q minus syndrome 76.75 12.90 27 222579 267 110366426
Balance disorder 76.45 12.90 73 222533 116487 110250206
Lung infiltration 75.91 12.90 159 222447 24469 110342224
Live birth 75.38 12.90 23 222583 69461 110297232
Loss of consciousness 75.30 12.90 178 222428 196128 110170565
Rash pruritic 74.76 12.90 53 222553 98016 110268677
Therapy interrupted 74.67 12.90 7 222599 49815 110316878
Muscular weakness 74.18 12.90 254 222352 248214 110118479
Colitis 73.56 12.90 403 222203 101920 110264773
Vision blurred 73.34 12.90 91 222515 128931 110237762
Follicular lymphoma 73.19 12.90 34 222572 721 110365972
Pneumonia klebsiella 73.05 12.90 78 222528 6554 110360139
Paraesthesia 72.58 12.90 298 222308 276223 110090470
Night sweats 72.55 12.90 98 222508 133885 110232808
Recurrent cancer 72.46 12.90 58 222548 3365 110363328
Anaplastic lymphoma kinase gene mutation 72.36 12.90 22 222584 130 110366563
Varicella zoster virus infection 72.10 12.90 76 222530 6292 110360401
Pseudomonal bacteraemia 71.80 12.90 64 222542 4307 110362386
Therapy non-responder 71.55 12.90 552 222054 156755 110209938
Toxic erythema of chemotherapy 71.37 12.90 28 222578 384 110366309
Premature menopause 71.30 12.90 37 222569 1005 110365688
Smooth muscle cell neoplasm 71.14 12.90 41 222565 1376 110365317
Hallucination 70.74 12.90 60 222546 101372 110265321
Pseudomonal sepsis 70.44 12.90 89 222517 8957 110357736
Cardio-respiratory arrest 69.81 12.90 78 222528 115758 110250935
Pericardial effusion 69.39 12.90 263 222343 56954 110309739
Acute hepatitis B 69.21 12.90 30 222576 537 110366156
Pseudomonas infection 69.20 12.90 165 222441 27688 110339005
Cytogenetic abnormality 69.08 12.90 38 222568 1164 110365529
Nail disorder 68.86 12.90 16 222590 57919 110308774
Accidental overdose 68.61 12.90 11 222595 51823 110314870
Viral haemorrhagic cystitis 68.58 12.90 56 222550 3343 110363350
Clostridium difficile infection 68.58 12.90 246 222360 51883 110314810
Drug ineffective for unapproved indication 67.96 12.90 396 222210 102442 110264251
Chemotherapy 67.14 12.90 46 222560 2100 110364593
Hypoalbuminaemia 67.04 12.90 167 222439 28807 110337886
Neutropenic infection 66.60 12.90 54 222552 3191 110363502
Swelling face 66.38 12.90 53 222553 92268 110274425
Mucosal toxicity 65.98 12.90 31 222575 675 110366018
Product prescribing error 65.51 12.90 12 222594 51319 110315374
Peripheral sensorimotor neuropathy 65.30 12.90 58 222548 3885 110362808
Bacterial sepsis 64.97 12.90 92 222514 10334 110356359
Ileus 64.77 12.90 171 222435 30558 110336135
Immunosuppression 64.76 12.90 123 222483 17636 110349057
Remission not achieved 64.71 12.90 28 222578 499 110366194
Treatment noncompliance 64.67 12.90 33 222573 72957 110293736
SARS-CoV-2 test negative 64.65 12.90 45 222561 2108 110364585
Onychomadesis 64.40 12.90 8 222598 45655 110321038
Infusion related reaction 64.20 12.90 476 222130 380686 109986007
Plasma cell myeloma recurrent 64.13 12.90 75 222531 6967 110359726
Metastases to breast 63.26 12.90 25 222581 350 110366343
Pregnancy 62.93 12.90 13 222593 51054 110315639
Enterocolitis 62.72 12.90 126 222480 18823 110347870
Coronary artery disease 62.64 12.90 33 222573 71657 110295036
Acute myelomonocytic leukaemia 62.58 12.90 26 222580 417 110366276
Weight decreased 62.53 12.90 621 221985 467436 109899257
Extravasation 62.43 12.90 62 222544 4783 110361910
Post embolisation syndrome 62.39 12.90 18 222588 86 110366607
Liver function test increased 62.22 12.90 52 222554 88496 110278197
Hypertriglyceridaemia 61.54 12.90 114 222492 16040 110350653
Glioblastoma multiforme 61.49 12.90 38 222568 1452 110365241
Chronic myeloid leukaemia 61.30 12.90 58 222548 4215 110362478
Plasma cell leukaemia 61.20 12.90 43 222563 2045 110364648
Troponin increased 61.08 12.90 164 222442 29602 110337091
Metastases to spine 60.91 12.90 64 222542 5279 110361414
Anal inflammation 60.89 12.90 46 222560 2450 110364243
Flagellate dermatitis 60.59 12.90 23 222583 287 110366406
Rectal haemorrhage 60.59 12.90 92 222514 119741 110246952
Cataract 60.53 12.90 43 222563 79442 110287251
Renal-limited thrombotic microangiopathy 60.44 12.90 27 222579 521 110366172
Vasogenic cerebral oedema 60.43 12.90 44 222562 2214 110364479
Haematopoietic stem cell mobilisation 59.78 12.90 25 222581 408 110366285
Blood stem cell transplant failure 59.42 12.90 29 222577 689 110366004
Liver injury 58.79 12.90 135 222471 150278 110216415
Deep vein thrombosis 58.76 12.90 482 222124 139405 110227288
International normalised ratio increased 58.49 12.90 53 222553 86719 110279974
B-cell lymphoma 58.29 12.90 72 222534 7082 110359611
Metastases to bone marrow 58.12 12.90 32 222574 982 110365711
Drug withdrawal syndrome 57.97 12.90 5 222601 38049 110328644
Osteoporosis 57.84 12.90 54 222552 87098 110279595
Hypertransaminasaemia 57.38 12.90 141 222465 24114 110342579
Klebsiella sepsis 56.98 12.90 55 222551 4098 110362595
Atelectasis 56.87 12.90 183 222423 36529 110330164
Ileus paralytic 56.71 12.90 92 222514 11645 110355048
Mucormycosis 56.45 12.90 87 222519 10541 110356152
Neoplasm 56.44 12.90 89 222517 10998 110355695
Lip swelling 56.37 12.90 16 222590 50651 110316042
Cytomegalovirus viraemia 56.29 12.90 116 222490 17648 110349045
Laryngitis 56.14 12.90 9 222597 42402 110324291
Procedural pain 56.06 12.90 4 222602 35561 110331132
Leukoencephalopathy 55.62 12.90 80 222526 9115 110357578
Nail pigmentation 55.47 12.90 23 222583 367 110366326
Hypoxia 55.34 12.90 448 222158 129067 110237626
Chemotherapeutic drug level increased 55.29 12.90 25 222581 497 110366196
Feeling hot 55.28 12.90 61 222545 91045 110275648
Limb injury 54.55 12.90 6 222600 37630 110329063
Nightmare 54.34 12.90 7 222599 38856 110327837
Gastric perforation 54.34 12.90 58 222548 4871 110361822
Drug reaction with eosinophilia and systemic symptoms 54.32 12.90 51 222555 82044 110284649
Bone marrow infiltration 54.22 12.90 29 222577 839 110365854
Rhinorrhoea 53.68 12.90 77 222529 102589 110264104
Transient ischaemic attack 53.66 12.90 31 222575 63951 110302742
Limb discomfort 53.34 12.90 9 222597 40845 110325848
Lung disorder 53.09 12.90 185 222421 179862 110186831
B-cell lymphoma refractory 53.06 12.90 18 222588 158 110366535
Acute respiratory distress syndrome 52.95 12.90 230 222376 52968 110313725
Sopor 52.54 12.90 6 222600 36540 110330153
Blood creatine phosphokinase increased 52.48 12.90 42 222564 73035 110293658
Meningitis cryptococcal 52.44 12.90 56 222550 4706 110361987
Agitation 52.28 12.90 92 222514 112959 110253734
Refractory cancer 52.16 12.90 20 222586 257 110366436
Chloroma 52.04 12.90 28 222578 820 110365873
Drug clearance decreased 51.74 12.90 52 222554 4070 110362623
Mass 51.72 12.90 119 222487 19511 110347182
Device related infection 51.56 12.90 186 222420 39333 110327360
Osteosarcoma recurrent 51.17 12.90 17 222589 139 110366554
Ovarian failure 51.03 12.90 29 222577 947 110365746
Withdrawal syndrome 51.03 12.90 3 222603 31377 110335316
Metastases to meninges 50.73 12.90 57 222549 5071 110361622
Myelitis 50.72 12.90 46 222560 3167 110363526
Respiratory arrest 50.70 12.90 27 222579 58272 110308421
Colony stimulating factor therapy 50.36 12.90 25 222581 617 110366076
Blood pressure decreased 50.26 12.90 97 222509 114994 110251699
Retinitis 49.92 12.90 4 222602 32323 110334370
Ototoxicity 49.82 12.90 51 222555 4080 110362613
Subclavian vein thrombosis 49.59 12.90 43 222563 2789 110363904
Graft versus host disease 49.55 12.90 114 222492 18692 110348001
Ovarian cancer recurrent 49.45 12.90 25 222581 642 110366051
Oligohydramnios 49.43 12.90 50 222556 3944 110362749
Humoral immune defect 49.41 12.90 26 222580 727 110365966
Bone lesion 49.37 12.90 66 222540 7021 110359672
Small intestinal perforation 49.14 12.90 52 222554 4324 110362369
Haematochezia 49.04 12.90 99 222507 115425 110251268
Underdose 48.89 12.90 34 222572 63520 110303173
Myocarditis 48.55 12.90 152 222454 29903 110336790
Granulocyte count decreased 47.81 12.90 49 222557 3925 110362768
Taste disorder 47.69 12.90 37 222569 65350 110301343
Therapeutic response shortened 47.59 12.90 3 222603 29580 110337113
Respiratory syncytial virus infection 47.57 12.90 96 222510 14388 110352305
Respiratory tract congestion 47.15 12.90 4 222602 30853 110335840
Acne 46.96 12.90 6 222600 33514 110333179
Palpitations 46.66 12.90 164 222442 159048 110207645
Sneezing 46.61 12.90 5 222601 31979 110334714
Nervousness 46.20 12.90 9 222597 36842 110329851
Lymphadenitis 45.91 12.90 56 222550 5437 110361256
Subdural hygroma 45.77 12.90 23 222583 583 110366110
Eye pain 45.36 12.90 22 222584 50077 110316616
Diarrhoea 45.36 12.90 1855 220751 1137650 109229043
Head injury 45.30 12.90 15 222591 43002 110323691
Hypokalaemia 45.30 12.90 564 222042 181884 110184809
Geotrichum infection 45.23 12.90 29 222577 1183 110365510
Unevaluable event 45.15 12.90 32 222574 59195 110307498
Abdominal distension 45.12 12.90 190 222416 174913 110191780
Abdominal neoplasm 45.10 12.90 24 222582 687 110366006
Onychomycosis 45.09 12.90 11 222595 38520 110328173
Therapy cessation 44.92 12.90 17 222589 44840 110321853
Cardiac failure acute 44.79 12.90 128 222478 23950 110342743
Troponin I increased 44.63 12.90 55 222551 5397 110361296
T-cell type acute leukaemia 44.30 12.90 19 222587 331 110366362
Eczema 44.30 12.90 48 222558 72245 110294448
Autoimmune lymphoproliferative syndrome 44.22 12.90 17 222589 220 110366473
Perineal necrosis 44.21 12.90 16 222590 173 110366520
Clostridium bacteraemia 43.89 12.90 21 222585 477 110366216
Heart rate irregular 43.76 12.90 8 222598 34266 110332427
Serotonin syndrome 43.74 12.90 33 222573 59120 110307573
Vena cava thrombosis 43.71 12.90 44 222562 3450 110363243
Hydrothorax 43.68 12.90 32 222574 1626 110365067
Systolic dysfunction 43.55 12.90 49 222557 4366 110362327
Retroperitoneal lymphadenopathy 43.09 12.90 30 222576 1406 110365287
Gastrointestinal fungal infection 43.05 12.90 24 222582 755 110365938
Staphylococcal infection 42.80 12.90 264 222342 69680 110297013
Dry eye 42.72 12.90 30 222576 55763 110310930
Tumour necrosis 42.68 12.90 37 222569 2399 110364294
Capillary leak syndrome 42.59 12.90 51 222555 4857 110361836
Laboratory test abnormal 42.03 12.90 18 222588 44061 110322632
End stage renal disease 41.75 12.90 116 222490 21357 110345336
Stem cell transplant 41.74 12.90 48 222558 4379 110362314
Left ventricular failure 41.67 12.90 79 222527 11310 110355383
Labelled drug-drug interaction medication error 41.65 12.90 5 222601 29297 110337396
Alveolitis 41.64 12.90 48 222558 4391 110362302
Cutaneous calcification 41.63 12.90 16 222590 207 110366486
Venous thrombosis 41.54 12.90 67 222539 8438 110358255
Chylothorax 41.51 12.90 27 222579 1129 110365564
Disseminated intravascular coagulation 41.47 12.90 179 222427 41107 110325586
Alveolar soft part sarcoma 41.39 12.90 13 222593 87 110366606
Sinus congestion 41.37 12.90 6 222600 30453 110336240
Gastritis bacterial 40.99 12.90 21 222585 555 110366138
Influenza like illness 40.84 12.90 72 222534 88340 110278353
Vertigo 40.80 12.90 70 222536 86800 110279893
Eosinophilia 40.73 12.90 34 222572 57902 110308791
Obstructive airways disorder 40.68 12.90 21 222585 46128 110320565
Hyperferritinaemia 40.63 12.90 26 222580 1057 110365636
Dysplasia 40.59 12.90 32 222574 1816 110364877
Primary cardiac lymphoma 40.52 12.90 10 222596 22 110366671
Plasma cell myeloma refractory 40.44 12.90 33 222573 1968 110364725
Cerebral aspergillosis 40.41 12.90 35 222571 2267 110364426
Mucoepidermoid carcinoma of salivary gland 40.20 12.90 14 222592 134 110366559
Burning sensation 40.19 12.90 48 222558 69164 110297529
Cholelithiasis 40.11 12.90 41 222565 63381 110303312
Combined immunodeficiency 40.04 12.90 15 222591 180 110366513
Peripartum cardiomyopathy 39.97 12.90 15 222591 181 110366512
Philadelphia chromosome positive 39.83 12.90 24 222582 876 110365817
Vaccination failure 39.80 12.90 36 222570 2470 110364223
Clonal evolution 39.73 12.90 16 222590 236 110366457
Acute monocytic leukaemia 39.72 12.90 21 222585 593 110366100
Streptococcal bacteraemia 39.67 12.90 48 222558 4621 110362072
Delirium 39.62 12.90 139 222467 134886 110231807
Joint dislocation 39.54 12.90 10 222596 34180 110332513
Osteosarcoma metastatic 39.50 12.90 11 222595 45 110366648
Throat irritation 39.44 12.90 30 222576 53522 110313171
Osteolysis 39.34 12.90 52 222554 5471 110361222
Ill-defined disorder 39.31 12.90 172 222434 156681 110210012
Tooth malformation 39.30 12.90 14 222592 144 110366549
Product administration error 39.16 12.90 13 222593 37204 110329489
Surgery 39.13 12.90 17 222589 41266 110325427
Myelitis transverse 39.13 12.90 35 222571 2366 110364327
Invasive ductal breast carcinoma 39.00 12.90 57 222549 6589 110360104
Sinus disorder 38.97 12.90 9 222597 32719 110333974
Metastatic lymphoma 38.84 12.90 21 222585 621 110366072
Ganglioneuroblastoma 38.81 12.90 10 222596 28 110366665
Hyperkalaemia 38.39 12.90 142 222464 135654 110231039
T-cell lymphoma 38.35 12.90 29 222577 1547 110365146
Enterococcal sepsis 38.34 12.90 40 222566 3272 110363421
Synovial sarcoma 38.24 12.90 12 222594 80 110366613
Hepatic cirrhosis 38.11 12.90 48 222558 67578 110299115
Blast cells present 37.99 12.90 24 222582 954 110365739
Diabetes mellitus inadequate control 37.91 12.90 7 222599 29768 110336925
Aggression 37.76 12.90 38 222568 59172 110307521
Primary mediastinal large B-cell lymphoma recurrent 37.74 12.90 13 222593 120 110366573
Blood pressure diastolic abnormal 37.71 12.90 4 222602 25811 110340882
Depressed mood 37.68 12.90 40 222566 60769 110305924
Adverse reaction 37.59 12.90 7 222599 29587 110337106
Eye swelling 37.58 12.90 10 222596 33038 110333655
Osteosarcoma 37.53 12.90 18 222588 411 110366282
White blood cell count abnormal 37.32 12.90 57 222549 6852 110359841
Acute hepatic failure 37.31 12.90 159 222447 36309 110330384
Anaplastic large cell lymphoma T- and null-cell types recurrent 37.23 12.90 11 222595 58 110366635
Lymphocytosis 37.10 12.90 50 222556 5361 110361332
Pneumonia cytomegaloviral 37.04 12.90 57 222549 6897 110359796
Transformation to acute myeloid leukaemia 37.00 12.90 28 222578 1495 110365198
Recall phenomenon 36.90 12.90 27 222579 1369 110365324
Autoimmune neutropenia 36.84 12.90 21 222585 690 110366003
Endocarditis noninfective 36.78 12.90 16 222590 289 110366404
Disability 36.61 12.90 8 222598 30215 110336478
Unintentional medical device removal 36.57 12.90 65 222541 8858 110357835
Hip arthroplasty 36.54 12.90 35 222571 55778 110310915
Hyperbilirubinaemia 36.38 12.90 140 222466 30531 110336162
Gastroenteritis viral 36.37 12.90 9 222597 31217 110335476
Hallucination, auditory 36.32 12.90 5 222601 26392 110340301
Extrapyramidal disorder 36.30 12.90 7 222599 28860 110337833
Unresponsive to stimuli 36.24 12.90 45 222561 63745 110302948
Irritability 36.22 12.90 26 222580 47783 110318910
Oesophageal candidiasis 36.17 12.90 75 222531 11459 110355234
Vocal cord paralysis 36.05 12.90 37 222569 2969 110363724
Abortion spontaneous 36.02 12.90 12 222594 34270 110332423
West Nile viral infection 35.86 12.90 26 222580 1300 110365393
B-cell type acute leukaemia 35.76 12.90 27 222579 1437 110365256
Lactic acidosis 35.70 12.90 84 222522 92727 110273966
Paraparesis 35.67 12.90 45 222561 4521 110362172
Pneumoperitoneum 35.57 12.90 42 222564 3942 110362751
Toxoplasmosis 35.51 12.90 38 222568 3201 110363492
Muscle spasticity 35.32 12.90 14 222592 35901 110330792
Nodular regenerative hyperplasia 35.30 12.90 28 222578 1603 110365090
Ear pain 35.29 12.90 33 222573 53193 110313500
Rhabdomyosarcoma recurrent 35.24 12.90 13 222593 149 110366544
Device related thrombosis 35.13 12.90 39 222567 3423 110363270
Multiple sclerosis 35.05 12.90 5 222601 25693 110341000
Gastric stenosis 34.92 12.90 14 222592 204 110366489
Dysaesthesia 34.90 12.90 55 222551 6792 110359901
Pathogen resistance 34.89 12.90 96 222510 17576 110349117
Enterovirus infection 34.87 12.90 35 222571 2735 110363958
Kidney infection 34.87 12.90 5 222601 25594 110341099
Necrotising gastritis 34.84 12.90 11 222595 75 110366618
Angiocentric lymphoma 34.80 12.90 25 222581 1232 110365461
Foot fracture 34.77 12.90 5 222601 25541 110341152
Oxygen saturation decreased 34.74 12.90 180 222426 156802 110209891
Epstein-Barr virus infection reactivation 34.73 12.90 42 222564 4042 110362651
Soft tissue infection 34.72 12.90 47 222559 5060 110361633
Pneumothorax spontaneous 34.70 12.90 29 222577 1788 110364905
Pneumothorax 34.69 12.90 152 222454 35133 110331560
Blood disorder 34.61 12.90 67 222539 9743 110356950
Metastases to retroperitoneum 34.56 12.90 17 222589 411 110366282
Localised infection 34.50 12.90 22 222584 43026 110323667
Bone marrow necrosis 34.45 12.90 17 222589 414 110366279
Streptococcal infection 34.37 12.90 71 222535 10819 110355874
Ulcer haemorrhage 34.28 12.90 3 222603 22568 110344125
Pseudocirrhosis 34.23 12.90 22 222584 901 110365792
Premature delivery 34.05 12.90 137 222469 30495 110336198
Post-acute COVID-19 syndrome 34.01 12.90 27 222579 1548 110365145
Blood HIV RNA increased 33.90 12.90 31 222575 2157 110364536
Nail bed inflammation 33.90 12.90 30 222576 2000 110364693
Nasal mucosal disorder 33.80 12.90 29 222577 1854 110364839
Hepatic lesion 33.70 12.90 61 222545 8432 110358261
Embolism 33.67 12.90 90 222516 16199 110350494
Influenza 33.55 12.90 201 222405 168900 110197793
Metastases to spleen 33.51 12.90 21 222585 823 110365870
Skin haemorrhage 33.47 12.90 5 222601 24822 110341871
Product dose omission in error 33.45 12.90 4 222602 23508 110343185
Dementia 33.43 12.90 11 222595 31662 110335031
Hyperpyrexia 33.35 12.90 59 222547 8010 110358683
Leukaemia cutis 33.34 12.90 14 222592 231 110366462
Paraesthesia oral 33.32 12.90 13 222593 33658 110333035
Injection site rash 33.28 12.90 4 222602 23415 110343278
Iron deficiency anaemia 33.24 12.90 11 222595 31548 110335145
Emotional distress 33.18 12.90 25 222581 44822 110321871
Hepatosplenomegaly 33.11 12.90 54 222552 6865 110359828
Hepatic infarction 33.01 12.90 22 222584 959 110365734
Pyomyositis 32.94 12.90 20 222586 740 110365953
Renal tubular disorder 32.90 12.90 56 222550 7373 110359320
Liver function test abnormal 32.90 12.90 55 222551 68895 110297798
Intertrigo 32.85 12.90 24 222582 1214 110365479
Rhinovirus infection 32.77 12.90 73 222533 11716 110354977
Nasal abscess 32.51 12.90 13 222593 188 110366505
Stomatitis 32.42 12.90 742 221864 269500 110097193
Fat embolism syndrome 32.41 12.90 12 222594 139 110366554
Dysgeusia 32.32 12.90 57 222549 69928 110296765
Central nervous system enteroviral infection 32.28 12.90 11 222595 98 110366595
Respiratory depression 32.26 12.90 12 222594 31989 110334704
Soft tissue neoplasm 32.18 12.90 11 222595 99 110366594
Hepatic fibrosis 32.09 12.90 58 222548 8008 110358685
Left ventricular dilatation 32.04 12.90 25 222581 1397 110365296
Human herpesvirus 8 infection 31.94 12.90 28 222578 1843 110364850
Malnutrition 31.93 12.90 124 222482 27155 110339538
Fungal infection 31.86 12.90 193 222413 50613 110316080
Hepatopulmonary syndrome 31.84 12.90 13 222593 199 110366494
Cerebral venous sinus thrombosis 31.80 12.90 34 222572 2861 110363832
Leukoerythroblastosis 31.79 12.90 15 222591 330 110366363
Secondary immunodeficiency 31.74 12.90 43 222563 4633 110362060
Splenomegaly 31.70 12.90 115 222491 24383 110342310
Metastases to pleura 31.52 12.90 29 222577 2034 110364659
Chronic myelomonocytic leukaemia 31.41 12.90 22 222584 1041 110365652
Eye irritation 31.35 12.90 14 222592 33438 110333255
Depressed level of consciousness 31.35 12.90 118 222488 112160 110254533
Large intestinal ulcer perforation 31.33 12.90 10 222596 71 110366622
Chromosome analysis abnormal 31.30 12.90 14 222592 271 110366422
Glycosylated haemoglobin increased 31.29 12.90 5 222601 23614 110343079
Bone formation decreased 31.25 12.90 11 222595 109 110366584
Invasive lobular breast carcinoma 31.23 12.90 20 222586 814 110365879
Hepatitis C RNA increased 31.22 12.90 16 222590 423 110366270
Cerebral toxoplasmosis 31.21 12.90 35 222571 3107 110363586
Back disorder 31.19 12.90 3 222603 20919 110345774
Fungaemia 31.18 12.90 49 222557 6037 110360656
Adrenal insufficiency 31.16 12.90 168 222438 42222 110324471
Sinus tachycardia 31.14 12.90 174 222432 44319 110322374
Acute lung injury 31.13 12.90 35 222571 3116 110363577
Stenotrophomonas bacteraemia 31.07 12.90 14 222592 276 110366417
Hip fracture 30.98 12.90 16 222590 35135 110331558
Coma 30.92 12.90 127 222479 117742 110248951
Herpes zoster 30.86 12.90 344 222262 108035 110258658
Body temperature decreased 30.82 12.90 18 222588 36917 110329776
Therapy responder 30.78 12.90 16 222590 436 110366257
Lymphadenopathy mediastinal 30.69 12.90 46 222560 5438 110361255
Incorrect route of product administration 30.66 12.90 51 222555 64010 110302683
Blood pressure diastolic decreased 30.65 12.90 17 222589 35868 110330825
Miosis 30.64 12.90 4 222602 21979 110344714
Panic attack 30.64 12.90 10 222596 28930 110337763
Aplastic anaemia 30.52 12.90 113 222493 24195 110342498
Flatulence 30.46 12.90 36 222570 52113 110314580
Haematoma 30.42 12.90 44 222562 58432 110308261
Chromosomal deletion 30.30 12.90 12 222594 169 110366524
Blood urine present 30.23 12.90 6 222600 24239 110342454
Endometrial adenocarcinoma 30.20 12.90 23 222583 1240 110365453
Amenorrhoea 30.10 12.90 61 222545 9170 110357523
Ureteric compression 30.00 12.90 14 222592 300 110366393
Meningitis tuberculous 29.96 12.90 23 222583 1255 110365438
Secretion discharge 29.93 12.90 3 222603 20241 110346452
Necrosis 29.89 12.90 69 222537 11337 110355356
Splenic marginal zone lymphoma 29.86 12.90 10 222596 84 110366609
Brain oedema 29.84 12.90 133 222473 30965 110335728
Gastric disorder 29.67 12.90 15 222591 33342 110333351
Pyloric stenosis 29.65 12.90 17 222589 565 110366128
Quadriplegia 29.62 12.90 39 222567 4088 110362605
Tendonitis 29.46 12.90 8 222598 26075 110340618
Diabetes mellitus 29.36 12.90 102 222504 99279 110267414
Sleep apnoea syndrome 29.35 12.90 23 222583 40424 110326269
Full blood count abnormal 29.34 12.90 42 222564 56010 110310683
Positron emission tomogram abnormal 29.33 12.90 16 222590 482 110366211
Respiratory distress 29.28 12.90 238 222368 68636 110298057
Abdominal compartment syndrome 29.27 12.90 27 222579 1900 110364793
Amniotic fluid index decreased 29.07 12.90 8 222598 31 110366662
Streptococcal sepsis 29.04 12.90 43 222563 5029 110361664
Oophoritis 29.00 12.90 11 222595 137 110366556
Cutaneous T-cell lymphoma recurrent 28.87 12.90 10 222596 94 110366599
Maternal exposure timing unspecified 28.87 12.90 4 222602 21009 110345684
Jugular vein thrombosis 28.73 12.90 44 222562 5301 110361392
VIth nerve paresis 28.71 12.90 11 222595 141 110366552
Poor venous access 28.69 12.90 7 222599 24515 110342178
Joint effusion 28.67 12.90 4 222602 20901 110345792
Upper limb fracture 28.64 12.90 4 222602 20884 110345809
Photosensitivity reaction 28.61 12.90 8 222598 25581 110341112
Hot flush 28.53 12.90 56 222550 65980 110300713
Mesenteric abscess 28.50 12.90 11 222595 144 110366549
Abdominal mass 28.45 12.90 42 222564 4899 110361794
Cytomegalovirus colitis 28.38 12.90 51 222555 7010 110359683
Cardiac failure chronic 28.24 12.90 76 222530 13735 110352958
Ovarian epithelial cancer recurrent 28.18 12.90 7 222599 16 110366677
Pseudocellulitis 28.17 12.90 15 222591 430 110366263
Pulmonary alveolar haemorrhage 28.14 12.90 97 222509 20053 110346640
Granulocytopenia 28.07 12.90 72 222534 12643 110354050
Pneumonia bacterial 28.04 12.90 116 222490 26145 110340548
Blood potassium increased 28.04 12.90 16 222590 33233 110333460
Incorrect product administration duration 27.93 12.90 4 222602 20494 110346199
Paronychia 27.91 12.90 66 222540 11015 110355678
Muscle rigidity 27.85 12.90 7 222599 24024 110342669
Carotid intima-media thickness increased 27.81 12.90 10 222596 106 110366587
Lymphocyte count decreased 27.77 12.90 204 222402 57039 110309654
Fungal oesophagitis 27.77 12.90 21 222585 1120 110365573
Hepatosplenic candidiasis 27.52 12.90 17 222589 649 110366044
Impaired quality of life 27.45 12.90 13 222593 30004 110336689
Haemoglobin abnormal 27.44 12.90 58 222548 8980 110357713
Alpha haemolytic streptococcal infection 27.42 12.90 35 222571 3558 110363135
Electrolyte imbalance 27.39 12.90 147 222459 36881 110329812
Encephalitis viral 27.34 12.90 32 222574 2975 110363718
Campylobacter gastroenteritis 27.32 12.90 26 222580 1903 110364790
Movement disorder 27.31 12.90 20 222586 36384 110330309
Cerebral candidiasis 27.26 12.90 9 222597 72 110366621
Osteomyelitis bacterial 27.23 12.90 16 222590 557 110366136
Systemic mycosis 27.20 12.90 36 222570 3793 110362900
Candida pneumonia 27.18 12.90 20 222586 1023 110365670
Tissue infiltration 27.18 12.90 20 222586 1023 110365670
Immune-mediated adrenal insuficiency 27.15 12.90 25 222581 1755 110364938
Disseminated cryptococcosis 27.08 12.90 30 222576 2627 110364066
Herpes virus infection 26.89 12.90 56 222550 8582 110358111
Haemorrhage 26.72 12.90 117 222489 106575 110260118
Anastomotic leak 26.70 12.90 22 222584 1330 110365363
Plasma cells increased 26.69 12.90 10 222596 120 110366573
Pulmonary embolism 26.69 12.90 592 222014 213882 110152811
Pneumonia viral 26.54 12.90 65 222541 11092 110355601
Lung adenocarcinoma 26.47 12.90 59 222547 9472 110357221
Leukaemic lymphoma 26.23 12.90 9 222597 82 110366611
Azoospermia 26.20 12.90 12 222594 246 110366447
Inappropriate antidiuretic hormone secretion 26.14 12.90 136 222470 33715 110332978
Pulse waveform abnormal 26.14 12.90 9 222597 83 110366610
Ankle brachial index decreased 26.14 12.90 9 222597 83 110366610
Hernia 26.12 12.90 4 222602 19496 110347197
Performance status decreased 26.09 12.90 50 222556 7216 110359477
Klebsiella bacteraemia 26.06 12.90 40 222566 4829 110361864
Biliary-bronchial fistula 26.05 12.90 5 222601 0 110366693
Poisoning 26.02 12.90 13 222593 29092 110337601
Hepatitis B DNA increased 25.98 12.90 18 222588 837 110365856
Creatinine renal clearance decreased 25.97 12.90 6 222600 21809 110344884
Abdominal wound dehiscence 25.96 12.90 13 222593 327 110366366
Cardiogenic shock 25.94 12.90 201 222405 57137 110309556
Squamous cell carcinoma of the oral cavity 25.92 12.90 17 222589 721 110365972
Hypersomnia 25.90 12.90 12 222594 28049 110338644
Viral load increased 25.84 12.90 33 222573 3357 110363336
Gastrointestinal obstruction 25.83 12.90 27 222579 2213 110364480
Mood swings 25.76 12.90 7 222599 22805 110343888
Encephalitis 25.71 12.90 90 222516 18749 110347944
Disorder of orbit 25.70 12.90 10 222596 134 110366559
Gas gangrene 25.67 12.90 13 222593 335 110366358
Cerebellar haemangioma 25.67 12.90 9 222597 88 110366605
Adrenocortical carcinoma 25.58 12.90 9 222597 89 110366604
Jejunal stenosis 25.57 12.90 10 222596 136 110366557
Tachypnoea 25.56 12.90 151 222455 39244 110327449
Rash erythematous 25.54 12.90 82 222524 81750 110284943
Pulmonary fibrosis 25.50 12.90 112 222494 101930 110264763
Retinal haemorrhage 25.48 12.90 58 222548 9443 110357250
Orthostatic hypotension 25.45 12.90 60 222546 66189 110300504
Carpal tunnel syndrome 25.41 12.90 7 222599 22603 110344090
Necrotising colitis 25.40 12.90 24 222582 1741 110364952
Skin cancer 25.36 12.90 3 222603 17781 110348912
Chronic hepatitis 25.32 12.90 24 222582 1748 110364945
Acute polyneuropathy 25.31 12.90 17 222589 751 110365942
Neurological symptom 25.27 12.90 79 222527 15529 110351164
Acute respiratory failure 25.26 12.90 247 222359 75013 110291680
Skin exfoliation 25.20 12.90 91 222515 87560 110279133
Systemic toxicity 25.19 12.90 13 222593 349 110366344
Epstein-Barr virus associated lymphoproliferative disorder 25.07 12.90 39 222567 4763 110361930
Adenovirus infection 25.05 12.90 63 222543 10931 110355762
Cytomegalovirus hepatitis 25.04 12.90 18 222588 888 110365805
Pericardial effusion malignant 25.02 12.90 12 222594 274 110366419
Bronchiectasis 24.94 12.90 22 222584 36471 110330222
Guillain-Barre syndrome 24.93 12.90 62 222544 10682 110356011
Obliterative bronchiolitis 24.91 12.90 34 222572 3689 110363004
Skin laceration 24.74 12.90 19 222587 33734 110332959
Cardiac imaging procedure abnormal 24.69 12.90 6 222600 12 110366681
Leukaemia recurrent 24.69 12.90 31 222575 3100 110363593
Mucosal disorder 24.65 12.90 37 222569 4380 110362313
Mastectomy 24.57 12.90 22 222584 1489 110365204
Hormone receptor positive breast cancer 24.54 12.90 15 222591 562 110366131
Thyroid dermatopathy 24.51 12.90 7 222599 32 110366661
Chromosomal mutation 24.45 12.90 8 222598 62 110366631
Facial paresis 24.37 12.90 44 222562 6069 110360624
Seasonal allergy 24.34 12.90 5 222601 19717 110346976
Stomatococcal infection 24.34 12.90 13 222593 375 110366318
Intestinal atresia 24.23 12.90 8 222598 64 110366629
Liver disorder 24.22 12.90 177 222429 142066 110224627
Sputum discoloured 24.21 12.90 13 222593 27932 110338761
Ocular hyperaemia 24.16 12.90 26 222580 39260 110327433
Onycholysis 24.15 12.90 29 222577 2770 110363923
Diastolic dysfunction 24.11 12.90 67 222539 12337 110354356
Renal failure 24.11 12.90 612 221994 225962 110140731
Cancer fatigue 24.09 12.90 13 222593 383 110366310
Large intestine perforation 24.06 12.90 81 222525 16548 110350145
Ileal perforation 24.00 12.90 21 222585 1379 110365314
Myeloproliferative neoplasm 23.93 12.90 21 222585 1384 110365309
Troponin T increased 23.93 12.90 36 222570 4270 110362423
Product storage error 23.91 12.90 7 222599 21721 110344972
Acute pulmonary oedema 23.90 12.90 82 222524 16914 110349779
Metastases to soft tissue 23.89 12.90 16 222590 703 110365990
Lymphoproliferative disorder 23.89 12.90 48 222558 7170 110359523
B precursor type acute leukaemia 23.84 12.90 14 222592 487 110366206
Abnormal behaviour 23.83 12.90 26 222580 39013 110327680
Acute biphenotypic leukaemia 23.81 12.90 10 222596 165 110366528
Tooth disorder 23.76 12.90 15 222591 29494 110337199
Foetal growth restriction 23.74 12.90 30 222576 3020 110363673
Metastases to pelvis 23.71 12.90 17 222589 835 110365858
Toxic encephalopathy 23.71 12.90 76 222530 15138 110351555
Dyskinesia 23.66 12.90 42 222564 51404 110315289
Lymphoedema 23.65 12.90 75 222531 14854 110351839
Treatment failure 23.60 12.90 404 222202 276830 110089863
Morphoea 23.59 12.90 15 222591 603 110366090
Mediastinum neoplasm 23.59 12.90 9 222597 114 110366579
Blood loss anaemia 23.47 12.90 4 222602 18021 110348672
Rash macular 23.36 12.90 26 222580 38660 110328033
Hypofibrinogenaemia 23.33 12.90 27 222579 2480 110364213
Blood potassium decreased 23.28 12.90 46 222560 54068 110312625
Splenic lesion 23.22 12.90 15 222591 620 110366073
Spinal stenosis 23.17 12.90 5 222601 19051 110347642
Skin mass 23.15 12.90 57 222549 9759 110356934
Back pain 23.15 12.90 569 222037 370427 109996266
Infection 23.15 12.90 920 221686 361280 110005413
Human polyomavirus infection 23.11 12.90 23 222583 1779 110364914
Head discomfort 23.08 12.90 5 222601 18995 110347698
Metastatic neoplasm 23.07 12.90 42 222564 5831 110360862
Epstein Barr virus positive mucocutaneous ulcer 23.07 12.90 19 222587 1148 110365545
Oral fungal infection 23.02 12.90 36 222570 4416 110362277
Vascular injury 23.01 12.90 19 222587 1152 110365541
Urinary tract infection 23.01 12.90 491 222115 325791 110040902
Cyst 23.00 12.90 3 222603 16493 110350200
Hypophagia 22.99 12.90 183 222423 52443 110314250
Respiratory tract infection fungal 22.98 12.90 20 222586 1304 110365389
Coordination abnormal 22.96 12.90 11 222595 25217 110341476
Meningitis aseptic 22.95 12.90 57 222549 9813 110356880
Aeromonas infection 22.94 12.90 14 222592 523 110366170
Radiotherapy 22.89 12.90 21 222585 1467 110365226
Accidental exposure to product 22.84 12.90 41 222565 49967 110316726
Marginal zone lymphoma recurrent 22.80 12.90 7 222599 43 110366650
Enterovirus test positive 22.79 12.90 12 222594 336 110366357
Heavy menstrual bleeding 22.76 12.90 3 222603 16362 110350331
Food allergy 22.75 12.90 6 222600 19942 110346751
Primary immunodeficiency syndrome 22.75 12.90 8 222598 79 110366614
Abdominal abscess 22.73 12.90 53 222553 8766 110357927
Gout 22.71 12.90 24 222582 36542 110330151
Device electrical impedance issue 22.60 12.90 5 222601 5 110366688
Ovarian cancer metastatic 22.51 12.90 16 222590 775 110365918
Asthenospermia 22.39 12.90 7 222599 46 110366647
Skin abrasion 22.36 12.90 3 222603 16148 110350545
Atypical haemolytic uraemic syndrome 22.28 12.90 21 222585 1519 110365174
Chronic hepatitis B 22.24 12.90 14 222592 553 110366140
Arrhythmogenic right ventricular dysplasia 22.23 12.90 8 222598 85 110366608
Bone density decreased 22.16 12.90 3 222603 16039 110350654
Nervous system disorder 22.16 12.90 124 222482 31597 110335096
Restless legs syndrome 22.01 12.90 11 222595 24615 110342078
Device related sepsis 21.99 12.90 48 222558 7599 110359094
Metastases to abdominal wall 21.97 12.90 10 222596 202 110366491
Sarcoma metastatic 21.90 12.90 8 222598 89 110366604
Electrocardiogram QT prolonged 21.88 12.90 129 222477 108831 110257862
Device dislocation 21.80 12.90 19 222587 31685 110335008
Gastrointestinal necrosis 21.79 12.90 44 222562 6596 110360097
Mitral valve incompetence 21.79 12.90 128 222478 33201 110333492
Glaucoma 21.78 12.90 9 222597 22508 110344185
Axillary lymphadenectomy 21.74 12.90 8 222598 91 110366602
Bacterial infection 21.73 12.90 163 222443 45873 110320820
Infusion site streaking 21.73 12.90 14 222592 576 110366117
Deafness bilateral 21.69 12.90 27 222579 2677 110364016
Taeniasis 21.66 12.90 7 222599 52 110366641
Helicobacter sepsis 21.65 12.90 6 222600 24 110366669
Ovarian stromal hyperplasia 21.65 12.90 6 222600 24 110366669
Duodenal stenosis 21.63 12.90 17 222589 960 110365733
Poor quality sleep 21.62 12.90 15 222591 28062 110338631
Acute erythroid leukaemia 21.60 12.90 12 222594 375 110366318
Erythropenia 21.58 12.90 13 222593 474 110366219
Subileus 21.54 12.90 43 222563 6394 110360299
Angioimmunoblastic T-cell lymphoma recurrent 21.46 12.90 6 222600 25 110366668
Babesiosis 21.39 12.90 13 222593 482 110366211
Pneumonia respiratory syncytial viral 21.33 12.90 27 222579 2722 110363971
Candida sepsis 21.28 12.90 28 222578 2933 110363760
Rotator cuff syndrome 21.27 12.90 4 222602 16790 110349903
Parkinsonism 21.25 12.90 9 222597 22178 110344515
Walking aid user 21.24 12.90 12 222594 25063 110341630
Mydriasis 21.20 12.90 9 222597 22148 110344545
Perineal infection 21.20 12.90 16 222590 851 110365842
Vaginal discharge 21.17 12.90 5 222601 17903 110348790
Fusarium infection 21.16 12.90 27 222579 2744 110363949
Anger 21.15 12.90 6 222600 19001 110347692
Device issue 21.08 12.90 23 222583 34512 110332181
Premature ageing 21.06 12.90 8 222598 100 110366593
Productive cough 21.05 12.90 139 222467 114166 110252527
Obstruction gastric 21.01 12.90 23 222583 1988 110364705
Device pacing issue 20.98 12.90 9 222597 157 110366536
Aortitis 20.97 12.90 23 222583 1992 110364701
Blood pressure systolic abnormal 20.89 12.90 12 222594 24838 110341855
Retinopathy haemorrhagic 20.85 12.90 8 222598 103 110366590
Female genital tract fistula 20.78 12.90 4 222602 16515 110350178
Superior vena cava syndrome 20.78 12.90 19 222587 1322 110365371
C-reactive protein increased 20.73 12.90 311 222295 217608 110149085
Neutrophil count increased 20.70 12.90 130 222476 34522 110332171
Crying 20.67 12.90 13 222593 25615 110341078
Blood calcium decreased 20.66 12.90 25 222581 35820 110330873
Delusion 20.66 12.90 11 222595 23744 110342949
Gastrointestinal protozoal infection 20.64 12.90 8 222598 106 110366587
Marginal zone lymphoma 20.59 12.90 10 222596 235 110366458
Parasitic gastroenteritis 20.51 12.90 10 222596 237 110366456
Hepatic angiosarcoma 20.51 12.90 8 222598 108 110366585
Joint neoplasm 20.48 12.90 7 222599 63 110366630
Clonal haematopoiesis 20.47 12.90 9 222597 167 110366526
Resorption bone increased 20.45 12.90 20 222586 1514 110365179
Gastrointestinal disorder 20.45 12.90 353 222253 241599 110125094
Ageusia 20.43 12.90 7 222599 19638 110347055
Angioimmunoblastic T-cell lymphoma 20.42 12.90 14 222592 640 110366053
Leiomyosarcoma metastatic 20.41 12.90 6 222600 31 110366662
Adenocarcinoma gastric 20.38 12.90 23 222583 2056 110364637
Hydronephrosis 20.30 12.90 89 222517 20576 110346117
Metastases to eye 20.29 12.90 11 222595 327 110366366
Body dysmorphic disorder 20.29 12.90 12 222594 423 110366270
Clostridium colitis 20.28 12.90 29 222577 3286 110363407
Basal ganglion degeneration 20.26 12.90 12 222594 424 110366269
Iron deficiency 20.25 12.90 6 222600 18470 110348223
Bicytopenia 20.24 12.90 43 222563 6681 110360012
Increased appetite 20.23 12.90 3 222603 14974 110351719
Neuroborreliosis 20.13 12.90 9 222597 174 110366519
IIIrd nerve paralysis 20.11 12.90 19 222587 1378 110365315
Epstein-Barr viraemia 20.00 12.90 30 222576 3549 110363144
Cardiac tamponade 19.96 12.90 59 222547 11248 110355445
Cardiac ventricular thrombosis 19.95 12.90 28 222578 3119 110363574
Refractory cytopenia with multilineage dysplasia 19.92 12.90 10 222596 253 110366440
Blood glucose decreased 19.88 12.90 18 222588 29470 110337223
Respiratory rate increased 19.85 12.90 13 222593 25070 110341623
Rhabdomyosarcoma 19.85 12.90 9 222597 180 110366513
Akathisia 19.80 12.90 5 222601 17108 110349585
Fear 19.79 12.90 11 222595 23182 110343511
Intervertebral disc protrusion 19.78 12.90 16 222590 27682 110339011
Neurofibrosarcoma 19.74 12.90 10 222596 258 110366435
Cough 19.68 12.90 745 221861 460896 109905797
KMT2A gene mutation 19.66 12.90 6 222600 36 110366657
Renal disorder 19.66 12.90 44 222562 49435 110317258
Chronic lymphocytic leukaemia refractory 19.62 12.90 8 222598 122 110366571
Exposure during pregnancy 19.55 12.90 229 222377 167195 110199498
Photophobia 19.54 12.90 14 222592 25757 110340936
Intussusception 19.53 12.90 20 222586 1601 110365092
Respiratory moniliasis 19.48 12.90 12 222594 456 110366237
Hyperleukocytosis 19.47 12.90 29 222577 3410 110363283
Chest discomfort 19.46 12.90 240 222366 173608 110193085
Acanthosis 19.46 12.90 13 222593 569 110366124
Gallbladder disorder 19.40 12.90 9 222597 21020 110345673
Cachexia 19.40 12.90 64 222542 12941 110353752
Tracheo-oesophageal fistula 19.40 12.90 14 222592 695 110365998
Uterine enlargement 19.39 12.90 16 222590 969 110365724
Encephalitis enteroviral 19.39 12.90 10 222596 268 110366425
Herpes simplex encephalitis 19.36 12.90 15 222591 830 110365863
Rhinitis allergic 19.31 12.90 6 222600 17916 110348777
Vulvovaginitis 19.28 12.90 11 222595 362 110366331
Haemoptysis 19.27 12.90 76 222530 71278 110295415
Transaminases 19.23 12.90 7 222599 77 110366616
Wrist fracture 19.21 12.90 3 222603 14414 110352279
Thrombocytopenic purpura 19.21 12.90 27 222579 3012 110363681
Heart rate abnormal 19.20 12.90 44 222562 7194 110359499
Schizophrenia 19.14 12.90 10 222596 21816 110344877
Transplant rejection 19.09 12.90 13 222593 24554 110342139
Blood pressure diastolic increased 19.04 12.90 7 222599 18800 110347893
Acute lymphocytic leukaemia refractory 19.03 12.90 9 222597 199 110366494
Febrile infection 19.00 12.90 33 222573 4415 110362278
Metastases to muscle 18.96 12.90 11 222595 374 110366319
Mantle cell lymphoma refractory 18.94 12.90 8 222598 134 110366559
Chronic lymphocytic leukaemia transformation 18.90 12.90 10 222596 283 110366410
Candida endophthalmitis 18.79 12.90 9 222597 205 110366488
Diffuse alopecia 18.75 12.90 18 222588 1332 110365361
Vulvovaginal inflammation 18.71 12.90 14 222592 735 110365958
Human herpesvirus 7 infection 18.71 12.90 9 222597 207 110366486
Renal salt-wasting syndrome 18.70 12.90 15 222591 873 110365820
Mucoepidermoid carcinoma 18.69 12.90 7 222599 84 110366609
Hyperlipidaemia 18.62 12.90 27 222579 35821 110330872
Drug level decreased 18.62 12.90 7 222599 18541 110348152
Medical device site oedema 18.61 12.90 4 222602 3 110366690
Retroperitoneal mass 18.55 12.90 10 222596 294 110366399
Amputation stump pain 18.51 12.90 6 222600 45 110366648
Urethral obstruction 18.49 12.90 10 222596 296 110366397
Mood altered 18.44 12.90 10 222596 21365 110345328
Enteritis 18.43 12.90 82 222524 19074 110347619
Splenic candidiasis 18.39 12.90 7 222599 88 110366605
Cutaneous T-cell lymphoma 18.39 12.90 28 222578 3356 110363337
Dermatitis contact 18.38 12.90 3 222603 13950 110352743
Gastrointestinal perforation 18.34 12.90 44 222562 7412 110359281
Liver abscess 18.32 12.90 45 222561 7694 110358999
Dystonia 18.32 12.90 15 222591 25790 110340903
Therapeutic response delayed 18.31 12.90 18 222588 1372 110365321
Neuroendocrine carcinoma of the skin 18.30 12.90 20 222586 1725 110364968
Neurological examination abnormal 18.30 12.90 14 222592 760 110365933
Lipidosis 18.29 12.90 6 222600 47 110366646
Lymphadenitis viral 18.25 12.90 7 222599 90 110366603
Infusion site necrosis 18.25 12.90 7 222599 90 110366603
Eastern Cooperative Oncology Group performance status worsened 18.21 12.90 26 222580 2943 110363750
Adult T-cell lymphoma/leukaemia 18.12 12.90 11 222595 407 110366286
Fracture 18.11 12.90 14 222592 24774 110341919
Peripheral blood stem cell apheresis 18.07 12.90 8 222598 151 110366542
Paranasal sinus mucosal hypertrophy 18.04 12.90 7 222599 93 110366600
Cryptococcosis 18.04 12.90 33 222573 4598 110362095
Enterocolitis infectious 18.02 12.90 28 222578 3416 110363277
Neutrophilic dermatosis 18.01 12.90 14 222592 778 110365915
Ligament sprain 18.01 12.90 5 222601 16063 110350630
Graft versus host disease in gastrointestinal tract 17.98 12.90 49 222557 8919 110357774
Lymphatic duct injury 17.96 12.90 6 222600 50 110366643
Cellulitis gangrenous 17.93 12.90 11 222595 415 110366278
Paraplegia 17.92 12.90 39 222567 6161 110360532
Pulmonary vein stenosis 17.88 12.90 8 222598 155 110366538
Cardiac murmur 17.88 12.90 14 222592 24614 110342079
Thrombocytopenia neonatal 17.85 12.90 5 222601 21 110366672
Angiosarcoma recurrent 17.85 12.90 5 222601 21 110366672
Necrotising fasciitis 17.82 12.90 44 222562 7547 110359146
Meningoencephalitis viral 17.81 12.90 12 222594 533 110366160
Sinus polyp 17.79 12.90 13 222593 658 110366035
TP53 gene mutation 17.79 12.90 8 222598 157 110366536
Histiocytic sarcoma 17.78 12.90 7 222599 97 110366596
Pulmonary hypoplasia 17.75 12.90 6 222600 52 110366641
Pustular psoriasis 17.75 12.90 3 222603 13602 110353091
PIK3CA-activated mutation 17.75 12.90 13 222593 660 110366033
Plasmablastic lymphoma 17.73 12.90 14 222592 796 110365897
Metastases to chest wall 17.70 12.90 13 222593 663 110366030
Angina pectoris 17.69 12.90 65 222541 62230 110304463
Myasthenia gravis crisis 17.66 12.90 20 222586 1794 110364899
Radiation skin injury 17.63 12.90 19 222587 1613 110365080
Erythema 17.63 12.90 449 222157 290998 110075695
Retching 17.62 12.90 12 222594 22670 110344023
Toxic neuropathy 17.57 12.90 16 222590 1107 110365586
Musculoskeletal discomfort 17.57 12.90 13 222593 23525 110343168
Coronary artery occlusion 17.51 12.90 5 222601 15767 110350926
Tumour haemorrhage 17.51 12.90 35 222571 5210 110361483
Pneumonitis chemical 17.50 12.90 13 222593 675 110366018
Transaminases increased 17.50 12.90 200 222406 63190 110303503
Hypersensitivity pneumonitis 17.41 12.90 35 222571 5230 110361463
Hepatitis viral 17.41 12.90 18 222588 1457 110365236
Oropharyngeal pain 17.40 12.90 181 222425 135095 110231598
Thymus enlargement 17.38 12.90 8 222598 166 110366527
Acute leukaemia 17.35 12.90 20 222586 1829 110364864
Urethritis 17.35 12.90 13 222593 684 110366009
Neurological decompensation 17.34 12.90 41 222565 6842 110359851
Angiosarcoma 17.34 12.90 12 222594 557 110366136
Cryptosporidiosis infection 17.33 12.90 16 222590 1127 110365566
B-lymphocyte count decreased 17.26 12.90 21 222585 2034 110364659
Hepatic function abnormal 17.25 12.90 264 222342 89031 110277662
Salivary gland neoplasm 17.21 12.90 7 222599 106 110366587
Peritonitis viral 17.18 12.90 6 222600 58 110366635
Hepatic amoebiasis 17.16 12.90 7 222599 107 110366586
Endothelial dysfunction 17.15 12.90 10 222596 343 110366350
Urinary retention 17.10 12.90 77 222529 69606 110297087
Drug tolerance 17.09 12.90 6 222600 16579 110350114
Radiation necrosis 17.08 12.90 14 222592 840 110365853
Diabetic ketoacidosis 17.04 12.90 37 222569 42021 110324672
Spindle cell sarcoma 17.00 12.90 9 222597 255 110366438
Osteopenia 16.93 12.90 12 222594 22197 110344496
Leukoplakia oral 16.85 12.90 11 222595 463 110366230
Device adhesion issue 16.84 12.90 49 222557 9261 110357432
Angina unstable 16.84 12.90 6 222600 16426 110350267
Eye disorder 16.83 12.90 20 222586 28886 110337807
Cancer in remission 16.82 12.90 6 222600 62 110366631
Histoplasmosis disseminated 16.75 12.90 29 222577 3870 110362823
Hypoproteinaemia 16.73 12.90 37 222569 5908 110360785
Anaesthesia 16.69 12.90 12 222594 592 110366101
Spinal column injury 16.69 12.90 22 222584 2309 110364384
Hepatitis B surface antigen positive 16.67 12.90 8 222598 183 110366510
Ecchymosis 16.66 12.90 7 222599 17331 110349362
Natural killer-cell lymphoblastic lymphoma 16.65 12.90 6 222600 64 110366629
Pelvic fracture 16.64 12.90 4 222602 14150 110352543
Non-cirrhotic portal hypertension 16.64 12.90 13 222593 728 110365965
Disseminated blastomycosis 16.62 12.90 11 222595 474 110366219
Tenosynovitis 16.59 12.90 6 222600 16277 110350416
Cerebellar stroke 16.55 12.90 14 222592 878 110365815
Burkholderia cepacia complex infection 16.54 12.90 11 222595 478 110366215
Meningitis pneumococcal 16.53 12.90 13 222593 735 110365958
Hepatomegaly 16.51 12.90 86 222520 21328 110345365
Trichodysplasia spinulosa 16.51 12.90 15 222591 1035 110365658
Eructation 16.47 12.90 4 222602 14053 110352640
Diffuse large B-cell lymphoma stage IV 16.47 12.90 14 222592 884 110365809
Thrombophlebitis 16.45 12.90 43 222563 7636 110359057
Epilepsy 16.43 12.90 126 222480 100083 110266610
Quadriparesis 16.42 12.90 32 222574 4675 110362018
Odynophagia 16.42 12.90 64 222542 14037 110352656
T-cell prolymphocytic leukaemia 16.40 12.90 6 222600 67 110366626
Pleural disorder 16.40 12.90 15 222591 1044 110365649
Lymph node haemorrhage 16.38 12.90 5 222601 30 110366663
Abdominal injury 16.37 12.90 10 222596 374 110366319
Upper respiratory tract infection 16.37 12.90 177 222429 131151 110235542
Mediastinal mass 16.36 12.90 13 222593 746 110365947
Intensive care 16.34 12.90 22 222584 2357 110364336
Gastrointestinal inflammation 16.33 12.90 49 222557 9420 110357273
Carbohydrate antigen 15-3 increased 16.32 12.90 18 222588 1569 110365124
Hypertensive crisis 16.29 12.90 15 222591 24357 110342336
Blindness 16.19 12.90 127 222479 36232 110330461
Speech disorder developmental 16.19 12.90 14 222592 905 110365788
Hyperuricaemia 16.16 12.90 65 222541 14466 110352227
B-cell aplasia 16.14 12.90 10 222596 384 110366309
Bladder perforation 16.14 12.90 10 222596 384 110366309
Pulmonary thrombosis 16.14 12.90 4 222602 13859 110352834
Vascular device infection 16.13 12.90 71 222535 16441 110350252
Platelet transfusion 16.11 12.90 24 222582 2822 110363871
Corynebacterium infection 16.09 12.90 20 222586 1980 110364713
Metabolic acidosis 16.08 12.90 126 222480 99618 110267075
Rib fracture 16.05 12.90 27 222579 33743 110332950
Toxic leukoencephalopathy 16.04 12.90 18 222588 1599 110365094
Haemorrhagic stroke 16.01 12.90 4 222602 13785 110352908
Periorbital cellulitis 16.01 12.90 15 222591 1077 110365616
Acute pulmonary histoplasmosis 16.00 12.90 9 222597 288 110366405
Oligospermia 15.98 12.90 5 222601 33 110366660
Lentigo 15.93 12.90 13 222593 775 110365918
Parainfluenzae virus infection 15.92 12.90 40 222566 6934 110359759
Anaphylactic reaction 15.92 12.90 150 222456 114150 110252543
Mental status changes 15.88 12.90 89 222517 76033 110290660
Necrotising soft tissue infection 15.86 12.90 11 222595 512 110366181
Metastases to the mediastinum 15.86 12.90 13 222593 780 110365913
Invasive breast carcinoma 15.83 12.90 13 222593 782 110365911
Mucosal infection 15.77 12.90 11 222595 517 110366176
Plasmablast count increased 15.72 12.90 5 222601 35 110366658
Secondary cerebellar degeneration 15.72 12.90 6 222600 76 110366617
Pulmonary artery stenosis 15.72 12.90 7 222599 134 110366559
Anaplastic large cell lymphoma T- and null-cell types 15.70 12.90 8 222598 209 110366484
Sphingomonas paucimobilis infection 15.67 12.90 7 222599 135 110366558
Cystitis viral 15.65 12.90 17 222589 1456 110365237
Omental infarction 15.63 12.90 3 222603 0 110366693
Administration site injury 15.63 12.90 3 222603 0 110366693
Wound evisceration 15.63 12.90 7 222599 136 110366557
Myofascitis 15.60 12.90 5 222601 36 110366657
Precursor T-lymphoblastic lymphoma/leukaemia 15.58 12.90 7 222599 137 110366556
Incontinence 15.53 12.90 7 222599 16628 110350065
Myelodysplastic syndrome transformation 15.52 12.90 13 222593 804 110365889
Peripheral coldness 15.52 12.90 9 222597 18531 110348162
Food protein-induced enterocolitis syndrome 15.48 12.90 5 222601 37 110366656
Blastic plasmacytoid dendritic cell neoplasia 15.45 12.90 6 222600 80 110366613
Anaplastic large-cell lymphoma 15.43 12.90 8 222598 217 110366476
Breath sounds abnormal 15.42 12.90 17 222589 25387 110341306
Listeria sepsis 15.40 12.90 13 222593 813 110365880
Proctalgia 15.39 12.90 60 222546 13162 110353531
Pulmonary mass 15.37 12.90 128 222478 37173 110329520
Faeces discoloured 15.36 12.90 28 222578 33920 110332773
Colitis microscopic 15.33 12.90 4 222602 13390 110353303
Metapneumovirus bronchiolitis 15.32 12.90 4 222602 12 110366681
Infusion site joint movement impairment 15.32 12.90 4 222602 12 110366681
DNA mismatch repair protein gene mutation 15.32 12.90 4 222602 12 110366681
Failure to thrive 15.32 12.90 61 222545 13513 110353180
Pneumonia salmonella 15.31 12.90 6 222600 82 110366611
Eating disorder 15.30 12.90 24 222582 30834 110335859
Torulopsis infection 15.26 12.90 5 222601 39 110366654
Infective aortitis 15.25 12.90 6 222600 83 110366610
Deafness 15.21 12.90 99 222507 26610 110340083
Adenoviral haemorrhagic cystitis 15.21 12.90 12 222594 682 110366011
Biliary fistula 15.17 12.90 7 222599 146 110366547
Tracheal fistula 15.16 12.90 8 222598 225 110366468
Hallucination, visual 15.11 12.90 36 222570 39569 110327124
Coagulopathy 15.09 12.90 137 222469 40774 110325919
Hyperglycaemia 15.09 12.90 248 222358 84842 110281851
Atrial fibrillation 15.06 12.90 585 222021 229057 110137636
Tidal volume decreased 15.05 12.90 6 222600 86 110366607
Stomatitis necrotising 15.03 12.90 8 222598 229 110366464
Central nervous system infection 15.03 12.90 18 222588 1714 110364979
Skin irritation 15.03 12.90 7 222599 16312 110350381
Squamous cell carcinoma of head and neck 15.00 12.90 9 222597 326 110366367
Retinitis pigmentosa 14.96 12.90 7 222599 151 110366542
Post procedural complication 14.94 12.90 19 222587 26639 110340054
Pneumonia pseudomonal 14.90 12.90 41 222565 7505 110359188
Toxicity to various agents 14.88 12.90 803 221803 479752 109886941
Gastric pneumatosis 14.83 12.90 5 222601 43 110366650
Blood pressure abnormal 14.75 12.90 14 222592 22410 110344283
Myocardial stunning 14.73 12.90 9 222597 337 110366356
Electrocardiogram QRS complex prolonged 14.69 12.90 4 222602 13017 110353676
Tendon rupture 14.67 12.90 5 222601 14073 110352620
Right ventricular dysfunction 14.65 12.90 25 222581 3298 110363395
Dermatitis bullous 14.64 12.90 72 222534 17457 110349236
Stevens-Johnson syndrome 14.63 12.90 47 222559 46854 110319839
Paresis 14.61 12.90 31 222575 4813 110361880
Blood urea increased 14.54 12.90 59 222547 54898 110311795
Rosai-Dorfman syndrome 14.53 12.90 5 222601 46 110366647
Feeling cold 14.53 12.90 29 222577 33958 110332735
Eye haemorrhage 14.50 12.90 3 222603 11771 110354922
Noctiphobia 14.44 12.90 4 222602 16 110366677
Metaplastic breast carcinoma 14.44 12.90 4 222602 16 110366677
Beta 2 microglobulin decreased 14.44 12.90 4 222602 16 110366677
Aphonia 14.42 12.90 4 222602 12856 110353837
Papillary thyroid cancer 14.41 12.90 23 222583 2871 110363822
Disseminated toxoplasmosis 14.39 12.90 10 222596 467 110366226
Klebsiella test positive 14.38 12.90 21 222585 2425 110364268
Temperature regulation disorder 14.36 12.90 4 222602 12822 110353871
Intestinal obstruction 14.27 12.90 167 222439 53060 110313633
Herpes zoster meningoencephalitis 14.27 12.90 14 222592 1064 110365629
Abdominal lymphadenopathy 14.26 12.90 18 222588 1810 110364883
Synovial sarcoma metastatic 14.24 12.90 4 222602 17 110366676
Metastases to vagina 14.24 12.90 4 222602 17 110366676
Myoclonus 14.24 12.90 28 222578 32970 110333723
Leukonychia 14.23 12.90 6 222600 100 110366593
Hyperfibrinogenaemia 14.20 12.90 7 222599 170 110366523
Vitamin D deficiency 14.17 12.90 10 222596 18542 110348151
Dysarthria 14.16 12.90 105 222501 84016 110282677
Portal vein embolism 14.12 12.90 6 222600 102 110366591
Platelet disorder 14.08 12.90 26 222580 3649 110363044
Disseminated cytomegaloviral infection 14.06 12.90 11 222595 617 110366076
Leiomyosarcoma recurrent 14.06 12.90 4 222602 18 110366675
Normal newborn 14.02 12.90 14 222592 21882 110344811
Molluscum contagiosum 14.00 12.90 11 222595 621 110366072
Scopulariopsis infection 13.98 12.90 7 222599 176 110366517
Arteriosclerosis coronary artery 13.97 12.90 18 222588 25100 110341593
Venous thrombosis limb 13.96 12.90 32 222574 5233 110361460
CD4 lymphocytes decreased 13.95 12.90 23 222583 2951 110363742
Intentional product use issue 13.92 12.90 386 222220 247520 110119173
Bartholinitis 13.90 12.90 5 222601 53 110366640
Li-Fraumeni syndrome 13.88 12.90 4 222602 19 110366674
Pneumonia adenoviral 13.88 12.90 11 222595 629 110366064
Diverticulitis 13.83 12.90 58 222548 53464 110313229
Pericardial calcification 13.82 12.90 5 222601 54 110366639
Enterobacter bacteraemia 13.79 12.90 16 222590 1474 110365219
Hepatitis C 13.79 12.90 56 222550 12517 110354176
Bacterial translocation 13.77 12.90 16 222590 1476 110365217
Anosmia 13.76 12.90 4 222602 12468 110354225
Extravasation blood 13.74 12.90 10 222596 503 110366190
Pneumaturia 13.74 12.90 5 222601 55 110366638
Aspergilloma 13.73 12.90 12 222594 787 110365906
Malignant neoplasm of orbit 13.71 12.90 4 222602 20 110366673
Lymph node fibrosis 13.71 12.90 4 222602 20 110366673
Hepatitis G 13.71 12.90 6 222600 110 110366583
BRCA2 gene mutation 13.71 12.90 6 222600 110 110366583
Fasciitis 13.70 12.90 13 222593 948 110365745
Graft complication 13.70 12.90 14 222592 1118 110365575
Encephalitis cytomegalovirus 13.63 12.90 18 222588 1892 110364801
Impaired work ability 13.62 12.90 20 222586 26399 110340294
Antithrombin III decreased 13.62 12.90 10 222596 510 110366183
Product dispensing error 13.59 12.90 8 222598 16337 110350356
Lacrimation increased 13.58 12.90 26 222580 30924 110335769
Adult T-cell lymphoma/leukaemia recurrent 13.58 12.90 5 222601 57 110366636
Brain abscess 13.57 12.90 37 222569 6737 110359956
T-cell lymphoma refractory 13.56 12.90 6 222600 113 110366580
Fluid replacement 13.56 12.90 13 222593 960 110365733
Pharyngeal inflammation 13.56 12.90 17 222589 1697 110364996
Angiosarcoma metastatic 13.56 12.90 7 222599 188 110366505
Splenic necrosis 13.56 12.90 7 222599 188 110366505
Increased liver stiffness 13.56 12.90 3 222603 3 110366690
Light chain analysis increased 13.53 12.90 20 222586 2335 110364358
Peripheral nerve injury 13.53 12.90 14 222592 1134 110365559
Paraneoplastic pemphigus 13.53 12.90 7 222599 189 110366504
Opsoclonus myoclonus 13.53 12.90 8 222598 282 110366411
Muscle strain 13.50 12.90 3 222603 11199 110355494
Intervertebral disc degeneration 13.48 12.90 10 222596 18075 110348618
Herpes simplex viraemia 13.45 12.90 11 222595 658 110366035
Ectropion 13.45 12.90 10 222596 520 110366173
Systemic inflammatory response syndrome 13.44 12.90 57 222549 12986 110353707
Hypoglossal nerve paresis 13.42 12.90 6 222600 116 110366577
Peritoneal disorder 13.38 12.90 12 222594 814 110365879
Acetabulum fracture 13.33 12.90 13 222593 981 110365712
Cholangitis sclerosing 13.30 12.90 25 222581 3557 110363136
Diaphragm muscle weakness 13.26 12.90 7 222599 197 110366496
Cerebral haemangioma 13.24 12.90 6 222600 120 110366573
Visceral leishmaniasis 13.24 12.90 17 222589 1739 110364954
Blood culture positive 13.23 12.90 44 222562 8932 110357761
Cerebellar syndrome 13.21 12.90 35 222571 6267 110360426
Disturbance in attention 13.20 12.90 72 222534 61923 110304770
Hiatus hernia 13.19 12.90 22 222584 27584 110339109
Drug effective for unapproved indication 13.15 12.90 60 222546 14107 110352586
Bacteroides bacteraemia 13.15 12.90 6 222600 122 110366571
Large intestine polyp 13.14 12.90 7 222599 15110 110351583
Ovarian cancer 13.10 12.90 28 222578 4368 110362325
Gastrointestinal wall thickening 13.09 12.90 25 222581 3598 110363095
Sarcoma 13.08 12.90 13 222593 1004 110365689
Anisocytosis 13.06 12.90 14 222592 1182 110365511
Hypogonadism 13.03 12.90 18 222588 1976 110364717
Sarcoidosis 12.99 12.90 55 222551 12524 110354169
Germ cell cancer 12.98 12.90 7 222599 206 110366487
Testicular germ cell tumour mixed 12.97 12.90 4 222602 25 110366668
Infusion site ulcer 12.97 12.90 4 222602 25 110366668
Renal cancer 12.95 12.90 5 222601 13029 110353664
Ichthyosis 12.95 12.90 7 222599 207 110366486
Kidney transplant rejection 12.94 12.90 4 222602 11983 110354710
Intraocular pressure increased 12.93 12.90 3 222603 10873 110355820
Pneumonia aspiration 12.92 12.90 103 222503 81130 110285563

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01DB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
FDA CS M0028312 Anthracyclines
FDA MoA N0000000176 Topoisomerase Inhibitors
FDA EPC N0000175414 Anthracycline Topoisomerase Inhibitor
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite

Related Drugs by ATC class:

L01DB Anthracyclines and related substances 10 drugs
aclarubicinamrubicindaunorubicinepirubicinidarubicinmitoxantronepirarubicinpixantronevalrubicinzorubicin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute myeloid leukemia, disease indication 91861009
Kaposi's sarcoma indication 109385007
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Small cell carcinoma of lung indication 254632001 DOID:5409
Carcinoma of breast indication 254838004 DOID:3459
Nephroblastoma indication 302849000 DOID:2154
Osteosarcoma of bone indication 307576001 DOID:3376
Follicular non-Hodgkin's lymphoma indication 308121000
Malignant tumor of lung indication 363358000
Advanced ovarian cancer indication 363443007 DOID:2394
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Kaposi's sarcoma associated with AIDS indication 420524008
Neuroblastoma indication 432328008 DOID:769
Carcinoma of female breast indication 447782002
Soft or Connective Tissue Sarcoma indication
Metastatic Breast Carcinoma indication
Invasive Bladder Malignancy indication
Metastatic Gastric Cancer indication
Carcinoid syndrome off-label use 35868009
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Malignant neoplasm of liver off-label use 93870000 DOID:3571
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Primary cutaneous T-cell lymphoma off-label use 400122007
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Pancreatic Neuroendocrine Tumor off-label use 717919005
Mycosis contraindication 3218000 DOID:1564
Bundle branch block contraindication 6374002
Hyperbilirubinemia contraindication 14783006 DOID:2741
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Conduction disorder of the heart contraindication 44808001
Myocarditis contraindication 50920009 DOID:820
Heart disease contraindication 56265001 DOID:114
Hepatic failure contraindication 59927004
Heart failure contraindication 84114007 DOID:6000
Leukopenia contraindication 84828003 DOID:615
Cardiomyopathy contraindication 85898001 DOID:0050700
Bacterial infectious disease contraindication 87628006
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Atrioventricular block contraindication 233917008 DOID:0050820
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Asymptomatic left ventricular systolic dysfunction contraindication 698592004
Protozoal Infection contraindication
Severe Cardiac Disease contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.85 acidic
pKa2 9.21 acidic
pKa3 9.92 acidic
pKa4 11.11 acidic
pKa5 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 6 CHEMBL CHEMBL
Multidrug resistance protein 1 Transporter IC50 4.01 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.43 DRUG MATRIX
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Caspase-1 Enzyme IC50 4.91 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.29 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.61 DRUG MATRIX
72 kDa type IV collagenase Enzyme IC50 5.96 CHEMBL
DNA topoisomerase 1 Enzyme IC50 4.70 CHEMBL
Telomerase reverse transcriptase Enzyme IC50 4.14 CHEMBL
DNA topoisomerase 2-beta Enzyme IC50 5.46 CHEMBL
Aurora kinase A Kinase IC50 7.40 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Membrane other Ki 5.46 CHEMBL
Glutamate carboxypeptidase 2 Enzyme IC50 5 CHEMBL
Ribonuclease pancreatic Enzyme IC50 4.60 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 4.87 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 4.81 DRUG MATRIX
Integrase Enzyme IC50 6.05 CHEMBL
Reverse transcriptase/RNaseH Enzyme IC50 4.28 CHEMBL
Reverse transcriptase Enzyme IC50 4.28 CHEMBL
Type-2 restriction enzyme HindIII Enzyme IC50 4.02 CHEMBL
Type-2 restriction enzyme ScaI Enzyme IC50 4.60 CHEMBL
ORF 73 Nuclear other AC50 5.84 CHEMBL
UDP-galactopyranose mutase Enzyme AC50 4.49 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 5.68 DRUG MATRIX
DNA Enzyme IC50 5.52 CHEMBL

External reference:

IDSource
4019737 VUID
N0000147829 NUI
D01275 KEGG_DRUG
25316-40-9 SECONDARY_CAS_RN
4018106 VANDF
4019737 VANDF
C0013089 UMLSCUI
CHEBI:28748 CHEBI
DM2 PDB_CHEM_ID
CHEMBL53463 ChEMBL_ID
CHEMBL359744 ChEMBL_ID
D004317 MESH_DESCRIPTOR_UI
DB00997 DRUGBANK_ID
7069 IUPHAR_LIGAND_ID
C506643 MESH_SUPPLEMENTAL_RECORD_UI
3005 INN_ID
80168379AG UNII
31703 PUBCHEM_CID
142433 RXNORM
3368 MMSL
4639 MMSL
47549 MMSL
d00218 MMSL
002659 NDDF
004818 NDDF
372817009 SNOMEDCT_US
68444001 SNOMEDCT_US
90875009 SNOMEDCT_US
80168379AG INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-0255 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-0277 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-0343 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-0358 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-1442 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-1542 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3030 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3032 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3033 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3034 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3358 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4004 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4004 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4015 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4015 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4026 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4026 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4037 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4037 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4205 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-5629 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9084 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9085 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9086 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9087 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9088 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9089 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9090 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections