doxorubicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastics, daunorubicin derivatives	960	23214-92-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: doxorubicin hydroxydaunomycin hydroxydaunorubicin rubidox doxorubicin hydrochloride liposomal doxorubicin hydroxydaunorubicin hydrochloride adriamycin doxorubicin HCl hydroxydaunorubicin HCl	Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. Molecular weight: 543.53 Formula: C27H29NO11 CLOGP: 0.26 LIPINSKI: 3 HAC: 12 HDO: 6 TPSA: 206.07 ALOGS: -2.67 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

doxorubicin
hydroxydaunomycin
hydroxydaunorubicin
rubidox
doxorubicin hydrochloride
liposomal doxorubicin
hydroxydaunorubicin hydrochloride
adriamycin
doxorubicin HCl
hydroxydaunorubicin HCl

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

Molecular weight: 543.53
Formula: C27H29NO11
CLOGP: 0.26
LIPINSKI: 3
HAC: 12
HDO: 6
TPSA: 206.07
ALOGS: -2.67
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	3.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	4.47 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	5 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	22 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	15 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.28 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	32 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Aug. 7, 1974	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	4780.46	12.98	2671	89369	94996	50418088
Neutropenia	2549.90	12.98	2123	89917	145842	50367242
Acute myeloid leukaemia	1089.33	12.98	537	91503	14537	50498547
Cardiotoxicity	915.78	12.98	378	91662	6649	50506435
Mucosal inflammation	912.44	12.98	680	91360	39462	50473622
Disease progression	843.33	12.98	953	91087	94913	50418171
Myelodysplastic syndrome	802.49	12.98	438	91602	14694	50498390
Thrombocytopenia	796.15	12.98	1067	90973	126606	50386478
Second primary malignancy	781.04	12.98	336	91704	6578	50506506
Haematotoxicity	776.32	12.98	348	91692	7547	50505537
Palmar-plantar erythrodysaesthesia syndrome	707.15	12.98	446	91594	19652	50493432
Malignant neoplasm progression	662.29	12.98	714	91326	67410	50445674
Product use in unapproved indication	640.77	12.98	914	91126	114905	50398179
Bone marrow failure	565.83	12.98	440	91600	27184	50485900
Pancytopenia	547.41	12.98	718	91322	83312	50429772
Cardiomyopathy	496.59	12.98	325	91715	15261	50497823
Diffuse large B-cell lymphoma recurrent	492.69	12.98	162	91878	1433	50511651
Ejection fraction decreased	491.86	12.98	345	91695	18175	50494909
Febrile bone marrow aplasia	468.19	12.98	229	91811	6082	50507002
Off label use	465.34	12.98	1896	90144	472530	50040554
Neoplasm progression	439.81	12.98	389	91651	28768	50484316
Anaemia	402.45	12.98	1187	90853	251269	50261815
Pneumocystis jirovecii pneumonia	368.18	12.98	264	91776	14399	50498685
Joint swelling	368.15	12.98	19	92021	245267	50267817
Metastases to bone	351.94	12.98	279	91761	17716	50495368
Rheumatoid arthritis	342.62	12.98	5	92035	202545	50310539
Ovarian failure	323.78	12.98	108	91932	1003	50512081
Neuropathy peripheral	312.90	12.98	600	91440	96157	50416927
Leukopenia	303.27	12.98	484	91556	67044	50446040
Left ventricular dysfunction	303.12	12.98	206	91834	10300	50502784
Cardiac failure	302.48	12.98	516	91524	75524	50437560
Tumour lysis syndrome	299.93	12.98	180	91860	7241	50505843
Pain	277.98	12.98	390	91650	578513	49934571
Fall	276.55	12.98	132	91908	334800	50178284
Septic shock	273.64	12.98	422	91618	56753	50456331
Abdominal discomfort	265.49	12.98	50	91990	231591	50281493
Pyrexia	261.38	12.98	1371	90669	378832	50134252
Neutrophil count decreased	261.05	12.98	368	91672	45658	50467426
Metastases to lung	250.81	12.98	187	91853	10833	50502251
Myelosuppression	243.99	12.98	200	91840	13317	50499767
Metastases to liver	240.86	12.98	236	91804	19868	50493216
Contraindicated product administered	238.71	12.98	7	92033	148951	50364133
Systemic lupus erythematosus	235.48	12.98	4	92036	140618	50372466
Bone pain	235.02	12.98	355	91685	46874	50466210
Sepsis	234.54	12.98	649	91391	132276	50380808
Neutropenic sepsis	233.97	12.98	199	91841	13948	50499136
Completed suicide	224.04	12.98	3	92037	131886	50381198
Headache	221.90	12.98	363	91677	506172	50006912
Hepatitis B reactivation	221.20	12.98	97	91943	1990	50511094
Diffuse large B-cell lymphoma refractory	221.05	12.98	80	91960	966	50512118
Congestive cardiomyopathy	220.81	12.98	133	91907	5385	50507699
Weight increased	214.10	12.98	52	91988	201839	50311245
Product dose omission issue	212.04	12.98	39	92001	183799	50329285
Peripheral swelling	210.79	12.98	57	91983	205879	50307205
Arthropathy	201.54	12.98	25	92015	157881	50355203
Drug hypersensitivity	199.37	12.98	104	91936	250906	50262178
Staphylococcal bacteraemia	198.91	12.98	119	91921	4758	50508326
Arthralgia	198.04	12.98	308	91732	438394	50074690
Swelling	197.46	12.98	60	91980	200812	50312272
Nasopharyngitis	194.45	12.98	55	91985	192872	50320212
Synovitis	194.24	12.98	7	92033	123858	50389226
Acute promyelocytic leukaemia	192.02	12.98	69	91971	815	50512269
Neutropenic colitis	186.16	12.98	90	91950	2327	50510757
Pruritus	182.47	12.98	149	91891	283419	50229665
Musculoskeletal stiffness	180.53	12.98	14	92026	128467	50384617
Disease recurrence	178.45	12.98	201	91839	19880	50493204
Posterior reversible encephalopathy syndrome	178.36	12.98	175	91865	14753	50498331
Therapeutic product effect decreased	172.48	12.98	22	92018	136028	50377056
Cytopenia	169.29	12.98	135	91905	8640	50504444
Therapy partial responder	168.49	12.98	120	91920	6471	50506613
Sinusitis	162.16	12.98	54	91986	170504	50342580
Ascites	156.73	12.98	254	91786	35607	50477477
Hepatitis B	155.62	12.98	90	91950	3376	50509708
Metastases to lymph nodes	154.95	12.98	117	91923	6907	50506177
Neurotoxicity	154.53	12.98	161	91879	14579	50498505
Wound	144.56	12.98	13	92027	105781	50407303
Dizziness	144.21	12.98	256	91784	346113	50166971
Rash	144.13	12.98	369	91671	437102	50075982
Anti-Muellerian hormone level decreased	142.71	12.98	34	92006	70	50513014
Pleural effusion	141.83	12.98	396	91644	81058	50432026
Injection site pain	135.87	12.98	20	92020	111004	50402080
Drug intolerance	134.90	12.98	120	91920	218984	50294100
Peripheral sensory neuropathy	134.89	12.98	105	91935	6486	50506598
Interstitial lung disease	133.16	12.98	297	91743	52879	50460205
Post transplant lymphoproliferative disorder	129.81	12.98	86	91954	4118	50508966
Insomnia	127.94	12.98	80	91960	174785	50338299
Stomatitis	125.78	12.98	438	91602	100906	50412178
Pneumonitis	124.86	12.98	206	91834	29304	50483780
Drug ineffective	122.97	12.98	931	91109	818402	49694682
Aplasia	122.60	12.98	80	91960	3733	50509351
Multiple organ dysfunction syndrome	118.10	12.98	274	91766	50063	50463021
Contusion	116.69	12.98	30	92010	112153	50400931
Discomfort	114.63	12.98	28	92012	108352	50404732
Progressive multifocal leukoencephalopathy	114.50	12.98	122	91918	11335	50501749
Platelet count decreased	114.48	12.98	423	91617	100303	50412781
B-cell lymphoma recurrent	112.77	12.98	38	92002	365	50512719
Somnolence	109.15	12.98	74	91966	154911	50358173
Urticaria	108.32	12.98	50	91990	129511	50383573
Muscle spasms	107.24	12.98	47	91993	125506	50387578
Feeling abnormal	107.15	12.98	47	91993	125445	50387639
Acute lymphocytic leukaemia recurrent	106.95	12.98	58	91982	1917	50511167
Lymphadenopathy	105.99	12.98	206	91834	33293	50479791
Polyneuropathy	103.65	12.98	119	91921	12012	50501072
Breast cancer recurrent	103.53	12.98	72	91968	3736	50509348
White blood cell count decreased	102.95	12.98	453	91587	116269	50396815
Pain in extremity	101.87	12.98	215	91825	272650	50240434
Overdose	101.20	12.98	28	92012	99699	50413385
Breast cancer metastatic	101.17	12.98	109	91931	10255	50502829
Metastases to central nervous system	100.35	12.98	113	91927	11169	50501915
Hepatic enzyme increased	100.26	12.98	63	91977	137317	50375767
Arthritis	98.62	12.98	19	92021	86702	50426382
Anxiety	98.06	12.98	107	91933	177499	50335585
Haemophagocytic lymphohistiocytosis	97.20	12.98	98	91942	8535	50504549
Small intestinal obstruction	96.31	12.98	132	91908	15936	50497148
Skin toxicity	94.88	12.98	69	91971	3844	50509240
Premature menopause	94.50	12.98	40	92000	750	50512334
Premature delivery	91.90	12.98	159	91881	23504	50489580
Blood pressure increased	91.83	12.98	65	91975	133067	50380017
Pericarditis	87.88	12.98	18	92022	78671	50434413
Injection site erythema	83.98	12.98	17	92023	74919	50438165
Hospitalisation	83.65	12.98	12	92028	67925	50445159
Epstein-Barr virus infection	83.52	12.98	82	91958	6915	50506169
Drug resistance	82.27	12.98	134	91906	18855	50494229
Neoplasm recurrence	81.83	12.98	52	91988	2317	50510767
Confusional state	81.28	12.98	133	91907	185795	50327289
Bacteraemia	81.18	12.98	115	91925	14318	50498766
Malaise	80.94	12.98	325	91715	335207	50177877
Asthma	80.23	12.98	31	92009	89306	50423778
Smooth muscle cell neoplasm	79.01	12.98	35	92005	736	50512348
Respiratory failure	78.95	12.98	352	91688	90829	50422255
Metastases to peritoneum	78.04	12.98	54	91986	2779	50510305
Gene mutation	76.36	12.98	40	92000	1231	50511853
Gait disturbance	75.69	12.98	97	91943	149908	50363176
Depression	75.46	12.98	115	91925	165308	50347776
Metastasis	75.32	12.98	63	91977	4312	50508772
Irritable bowel syndrome	73.96	12.98	5	92035	51436	50461648
Ileus	73.80	12.98	105	91935	13124	50499960
Neutrophil count abnormal	72.78	12.98	49	91991	2410	50510674
Condition aggravated	72.71	12.98	286	91754	296772	50216312
Metastases to breast	72.59	12.98	25	92015	258	50512826
Systemic candida	69.48	12.98	50	91990	2740	50510344
Myeloid leukaemia	68.99	12.98	25	92015	303	50512781
Bone marrow disorder	67.89	12.98	43	91997	1905	50511179
Bronchitis	67.77	12.98	54	91986	104105	50408979
Computerised tomogram thorax abnormal	67.70	12.98	38	92002	1345	50511739
Lymphopenia	67.35	12.98	110	91930	15511	50497573
Acute lymphocytic leukaemia	67.16	12.98	45	91995	2196	50510888
Refractory anaemia with an excess of blasts	67.15	12.98	26	92014	383	50512701
Abdominal pain upper	66.81	12.98	117	91923	159192	50353892
Osteoarthritis	66.42	12.98	21	92019	68585	50444499
Fibromyalgia	65.77	12.98	4	92036	44974	50468110
Blood cholesterol increased	65.14	12.98	11	92029	55204	50457880
Pneumatosis intestinalis	64.88	12.98	43	91997	2060	50511024
Acquired gene mutation	64.17	12.98	31	92009	800	50512284
Pericardial effusion	64.11	12.98	143	91897	25446	50487638
Gastrointestinal toxicity	63.79	12.98	59	91981	4618	50508466
Bronchopulmonary aspergillosis	62.39	12.98	73	91967	7519	50505565
Drug abuse	62.22	12.98	16	92024	59830	50453254
Loss of personal independence in daily activities	61.75	12.98	25	92015	70025	50443059
Leukaemia	61.52	12.98	51	91989	3448	50509636
Cataract	61.50	12.98	7	92033	47293	50465791
Hypogammaglobulinaemia	61.08	12.98	63	91977	5636	50507448
Injection site swelling	60.23	12.98	4	92036	41769	50471315
Wheezing	60.05	12.98	19	92021	62028	50451056
Ventricular hypokinesia	59.77	12.98	53	91987	3927	50509157
Agranulocytosis	58.56	12.98	124	91916	21297	50491787
Impaired healing	58.19	12.98	27	92013	69759	50443325
Injection site pruritus	57.88	12.98	4	92036	40407	50472677
Metastases to skin	57.06	12.98	34	92006	1349	50511735
Cystitis haemorrhagic	56.99	12.98	50	91990	3652	50509432
Pulmonary toxicity	56.94	12.98	60	91980	5502	50507582
Lower respiratory tract infection	56.31	12.98	54	91986	95147	50417937
Helicobacter infection	56.26	12.98	11	92029	49691	50463393
Varicella zoster virus infection	56.10	12.98	42	91998	2447	50510637
Encephalopathy	55.80	12.98	161	91879	33550	50479534
Lymphadenitis	55.79	12.98	43	91997	2617	50510467
Salivary gland cancer	55.26	12.98	18	92022	154	50512930
Stress	54.75	12.98	15	92025	53778	50459306
Capillary leak syndrome	54.36	12.98	37	92003	1853	50511231
Nephropathy toxic	54.33	12.98	70	91970	7959	50505125
Venoocclusive disease	54.26	12.98	37	92003	1859	50511225
Embolism	53.96	12.98	65	91975	6903	50506181
Intestinal perforation	53.84	12.98	80	91960	10399	50502685
Peripheral motor neuropathy	53.43	12.98	33	92007	1398	50511686
Balance disorder	53.39	12.98	31	92009	70559	50442525
Injection site reaction	52.73	12.98	13	92027	50019	50463065
White blood cell count abnormal	52.72	12.98	57	91983	5383	50507701
Pneumocystis jirovecii infection	51.70	12.98	31	92009	1244	50511840
Injection site bruising	51.63	12.98	4	92036	36764	50476320
Drug interaction	51.50	12.98	188	91852	199433	50313651
Venoocclusive liver disease	50.98	12.98	50	91990	4211	50508873
Inappropriate schedule of product administration	50.93	12.98	34	92006	71797	50441287
Atelectasis	50.22	12.98	106	91934	18164	50494920
Alopecia	50.21	12.98	252	91788	244795	50268289
Extravasation	50.13	12.98	36	92004	1966	50511118
Cerebrovascular accident	50.08	12.98	59	91981	94621	50418463
Suicide attempt	49.78	12.98	16	92024	51716	50461368
Memory impairment	49.32	12.98	43	91997	79317	50433767
Diffuse large B-cell lymphoma	49.14	12.98	56	91984	5606	50507478
Injury	49.12	12.98	14	92026	48911	50464173
Mobility decreased	48.87	12.98	44	91996	79904	50433180
Cardiomyopathy acute	48.64	12.98	17	92023	184	50512900
JC virus infection	48.60	12.98	34	92006	1781	50511303
Heart rate decreased	48.47	12.98	5	92035	36492	50476592
Metastases to pleura	48.46	12.98	30	92010	1276	50511808
Thrombotic microangiopathy	47.90	12.98	69	91971	8722	50504362
Tremor	47.60	12.98	85	91955	114818	50398266
5q minus syndrome	47.44	12.98	17	92023	199	50512885
Recurrent cancer	47.25	12.98	33	92007	1724	50511360
Acute hepatitis B	46.97	12.98	19	92021	316	50512768
Perineal infection	46.72	12.98	15	92025	122	50512962
Klebsiella infection	46.00	12.98	61	91979	7133	50505951
Folliculitis	45.86	12.98	8	92032	39217	50473867
Neutropenic infection	45.57	12.98	27	92013	1060	50512024
Nephrolithiasis	45.44	12.98	5	92035	34688	50478396
Cardiac failure acute	45.31	12.98	65	91975	8185	50504899
Suicidal ideation	45.30	12.98	22	92018	55363	50457721
Lymphoma transformation	45.09	12.98	15	92025	138	50512946
Pulmonary embolism	44.96	12.98	328	91712	101376	50411708
Philadelphia chromosome positive	44.70	12.98	19	92021	360	50512724
Fatigue	44.70	12.98	965	91075	706636	49806448
Blood glucose increased	43.90	12.98	39	92001	71285	50441799
Nasal congestion	43.84	12.98	19	92021	51101	50461983
Perineal necrosis	43.69	12.98	14	92026	113	50512971
Hypersensitivity	43.64	12.98	222	91818	214939	50298145
Cutaneous calcification	42.94	12.98	13	92027	85	50512999
Palpitations	42.77	12.98	66	91974	94440	50418644
Ovarian cancer recurrent	42.54	12.98	24	92016	858	50512226
Plasmacytoma	42.42	12.98	35	92005	2350	50510734
Respiratory syncytial virus infection	41.83	12.98	49	91991	5053	50508031
Alveolar soft part sarcoma	41.82	12.98	13	92027	94	50512990
Clonal evolution	41.25	12.98	12	92028	67	50513017
Metastases to spine	41.12	12.98	37	92003	2794	50510290
Myasthenia gravis crisis	41.01	12.98	18	92022	370	50512714
Gastrosplenic fistula	40.80	12.98	11	92029	44	50513040
Joint stiffness	40.65	12.98	4	92036	30304	50482780
Alveolitis	40.57	12.98	35	92005	2499	50510585
Gastrointestinal fungal infection	40.35	12.98	16	92024	252	50512832
Fluid retention	40.10	12.98	21	92019	50628	50462456
Central nervous system lymphoma	39.92	12.98	27	92013	1338	50511746
Pseudomonal sepsis	39.75	12.98	32	92008	2075	50511009
Enterococcal bacteraemia	39.48	12.98	26	92014	1232	50511852
Organising pneumonia	39.39	12.98	46	91994	4728	50508356
Treatment failure	39.31	12.98	124	91916	137513	50375571
Amnesia	39.04	12.98	14	92026	42246	50470838
Heart rate abnormal	38.99	12.98	42	91998	3950	50509134
Blood lactate dehydrogenase increased	38.94	12.98	100	91940	19462	50493622
Premature baby	38.87	12.98	96	91944	18241	50494843
Hypoxia	38.81	12.98	190	91850	50933	50462151
Migraine	38.65	12.98	48	91992	75232	50437852
Ileus paralytic	38.49	12.98	42	91998	4008	50509076
Secondary immunodeficiency	38.37	12.98	25	92015	1163	50511921
Squamous cell carcinoma of the oral cavity	38.35	12.98	16	92024	289	50512795
Myelopathy	38.25	12.98	34	92006	2527	50510557
Device related infection	38.22	12.98	103	91937	20632	50492452
Clostridium bacteraemia	38.10	12.98	14	92026	177	50512907
Adverse drug reaction	38.00	12.98	27	92013	55195	50457889
Primary cardiac lymphoma	37.95	12.98	9	92031	18	50513066
Gastrooesophageal reflux disease	37.93	12.98	50	91990	76378	50436706
Neck pain	37.85	12.98	29	92011	57038	50456046
Intertrigo	37.80	12.98	17	92023	371	50512713
Cardiogenic shock	37.76	12.98	86	91954	15513	50497571
Colony stimulating factor therapy	37.70	12.98	16	92024	302	50512782
Mucosal toxicity	37.51	12.98	16	92024	306	50512778
Chemotherapy	37.49	12.98	26	92014	1343	50511741
Hypoglycaemia	37.13	12.98	26	92014	53555	50459529
Premature labour	36.81	12.98	71	91969	11405	50501679
Bone lesion	36.44	12.98	46	91994	5124	50507960
T-cell type acute leukaemia	36.15	12.98	10	92030	45	50513039
Invasive ductal breast carcinoma	36.02	12.98	49	91991	5872	50507212
Myocardial infarction	35.85	12.98	67	91973	88960	50424124
Humoral immune defect	35.82	12.98	11	92029	76	50513008
Hypertriglyceridaemia	35.79	12.98	47	91993	5444	50507640
Mantle cell lymphoma recurrent	35.73	12.98	12	92028	114	50512970
Cardiac failure chronic	35.70	12.98	38	92002	3525	50509559
Visual impairment	35.61	12.98	43	91997	68232	50444852
Amniotic fluid index decreased	35.59	12.98	8	92032	11	50513073
Incorrect dose administered	35.57	12.98	22	92018	48392	50464692
Acute myelomonocytic leukaemia	35.33	12.98	13	92027	165	50512919
Hepatitis E	35.21	12.98	24	92016	1205	50511879
Ovarian epithelial cancer recurrent	35.18	12.98	8	92032	12	50513072
Flagellate dermatitis	35.12	12.98	13	92027	168	50512916
Mesenteric abscess	35.09	12.98	11	92029	82	50513002
Lung infiltration	34.85	12.98	76	91964	13317	50499767
Toxic cardiomyopathy	34.83	12.98	12	92028	124	50512960
Blast cells present	34.80	12.98	16	92024	368	50512716
Unintentional medical device removal	34.62	12.98	46	91994	5389	50507695
Enterococcal sepsis	34.41	12.98	24	92016	1251	50511833
Escherichia bacteraemia	34.39	12.98	35	92005	3081	50510003
Plasma cell leukaemia	34.36	12.98	22	92018	993	50512091
Osteomyelitis bacterial	34.05	12.98	13	92027	184	50512900
Haemoglobin abnormal	33.90	12.98	41	91999	4371	50508713
Body dysmorphic disorder	33.65	12.98	14	92026	251	50512833
Ill-defined disorder	33.49	12.98	30	92010	54624	50458460
Loss of consciousness	33.45	12.98	89	91951	104264	50408820
Limb discomfort	33.23	12.98	3	92037	24354	50488730
Musculoskeletal pain	33.05	12.98	50	91990	72127	50440957
Necrotising gastritis	32.95	12.98	10	92030	66	50513018
Hydrothorax	32.86	12.98	19	92021	712	50512372
Large intestinal ulcer perforation	32.82	12.98	10	92030	67	50513017
Metastases to meninges	32.76	12.98	28	92012	1974	50511110
Rhabdomyolysis	32.68	12.98	15	92025	39012	50474072
Localised infection	32.56	12.98	4	92036	25481	50487603
Exposure during pregnancy	32.54	12.98	350	91690	120665	50392419
Infection reactivation	32.45	12.98	21	92019	966	50512118
Mitral valve incompetence	32.42	12.98	87	91953	17384	50495700
Unevaluable event	32.39	12.98	22	92018	46044	50467040
Pyomyositis	32.20	12.98	15	92025	356	50512728
Hepatic failure	32.07	12.98	130	91910	32153	50480931
Colitis	32.01	12.98	147	91893	38382	50474702
Therapeutic response delayed	31.84	12.98	17	92023	544	50512540
Traumatic lung injury	31.77	12.98	24	92016	1417	50511667
Epstein-Barr virus associated lymphoma	31.76	12.98	16	92024	453	50512631
Leukoerythroblastosis	31.66	12.98	13	92027	225	50512859
Amenorrhoea	31.62	12.98	56	91984	8428	50504656
Bicytopenia	31.52	12.98	27	92013	1909	50511175
Pneumonia fungal	31.35	12.98	39	92001	4281	50508803
Respiratory arrest	31.23	12.98	8	92032	30001	50483083
Heart rate increased	31.22	12.98	58	91982	77192	50435892
Blood pressure fluctuation	31.22	12.98	13	92027	35810	50477274
Nail pigmentation	31.04	12.98	12	92028	176	50512908
Illness	30.99	12.98	4	92036	24536	50488548
Vision blurred	30.95	12.98	60	91980	78587	50434497
Hepatic infarction	30.88	12.98	17	92023	579	50512505
Irritability	30.72	12.98	7	92033	28419	50484665
Influenza	30.53	12.98	74	91966	89464	50423620
Cardiac dysfunction	30.33	12.98	25	92015	1676	50511408
Urinary tract infection	30.32	12.98	261	91779	223759	50289325
Cytomegalovirus viraemia	30.22	12.98	40	92000	4669	50508415
Radiation necrosis	30.18	12.98	14	92026	329	50512755
Nasal abscess	30.16	12.98	11	92029	136	50512948
Hypertransaminasaemia	30.13	12.98	35	92005	3576	50509508
Nodular regenerative hyperplasia	29.99	12.98	13	92027	259	50512825
C-reactive protein abnormal	29.75	12.98	7	92033	27802	50485282
Malignant transformation	29.68	12.98	14	92026	342	50512742
Carbohydrate antigen 125 increased	29.61	12.98	29	92011	2438	50510646
Angioedema	29.27	12.98	16	92024	37660	50475424
Emotional distress	29.15	12.98	8	92032	28655	50484429
Blood pressure systolic increased	29.11	12.98	14	92026	35435	50477649
Chronic myeloid leukaemia	29.02	12.98	27	92013	2129	50510955
Hepatotoxicity	28.95	12.98	112	91928	27114	50485970
Gastric disorder	28.67	12.98	9	92031	29539	50483545
Thyroid dermatopathy	28.59	12.98	7	92033	17	50513067
Vena cava thrombosis	28.54	12.98	26	92014	1995	50511089
Periorbital cellulitis	28.54	12.98	16	92024	565	50512519
Acute leukaemia	28.38	12.98	20	92020	1060	50512024
Cytogenetic abnormality	28.27	12.98	15	92025	474	50512610
Chest pain	28.18	12.98	197	91843	176685	50336399
Clostridium difficile infection	28.16	12.98	106	91934	25333	50487751
Blister	28.02	12.98	72	91968	85346	50427738
Quadriplegia	28.00	12.98	24	92016	1699	50511385
Ototoxicity	27.61	12.98	20	92020	1107	50511977
Agitation	27.44	12.98	34	92006	53350	50459734
Swollen tongue	27.28	12.98	9	92031	28621	50484463
T-cell lymphoma	27.24	12.98	16	92024	618	50512466
Left ventricular dilatation	27.23	12.98	14	92026	414	50512670
Leukaemic lymphoma	27.23	12.98	9	92031	81	50513003
Product quality issue	27.21	12.98	11	92029	30847	50482237
Bursitis	27.03	12.98	4	92036	22131	50490953
Systolic dysfunction	27.02	12.98	22	92018	1450	50511634
Hepatocellular injury	26.99	12.98	106	91934	25841	50487243
B-cell lymphoma refractory	26.84	12.98	9	92031	85	50512999
Intussusception	26.84	12.98	14	92026	427	50512657
Clonal haematopoiesis	26.80	12.98	6	92034	8	50513076
Infusion site streaking	26.75	12.98	14	92026	430	50512654
Cerebral venous sinus thrombosis	26.63	12.98	23	92017	1645	50511439
Tissue infiltration	26.54	12.98	15	92025	538	50512546
Enterococcal infection	26.32	12.98	46	91994	6852	50506232
Limb injury	26.31	12.98	3	92037	20247	50492837
Vocal cord paralysis	26.24	12.98	23	92017	1678	50511406
Hyperpyrexia	26.20	12.98	30	92010	3019	50510065
Platelet count abnormal	26.13	12.98	29	92011	2820	50510264
Metastases to the mediastinum	26.00	12.98	14	92026	456	50512628
Computerised tomogram thorax	25.97	12.98	10	92030	145	50512939
Cerebellar stroke	25.90	12.98	11	92029	208	50512876
Blood lactate dehydrogenase abnormal	25.90	12.98	11	92029	208	50512876
Hallucination	25.83	12.98	28	92012	46629	50466455
Clostridium difficile colitis	25.83	12.98	81	91959	17661	50495423
Toxic neuropathy	25.77	12.98	13	92027	369	50512715
Invasive breast carcinoma	25.76	12.98	15	92025	570	50512514
Metastases to soft tissue	25.66	12.98	10	92030	150	50512934
Pulmonary alveolar haemorrhage	25.52	12.98	34	92006	3993	50509091
Listeria sepsis	25.29	12.98	15	92025	590	50512494
Acne	25.22	12.98	3	92037	19592	50493492
Hyperhidrosis	25.22	12.98	81	91959	89345	50423739
Flatulence	25.17	12.98	11	92029	29447	50483637
Rash pruritic	25.09	12.98	30	92010	47816	50465268
Radiation skin injury	25.07	12.98	17	92023	846	50512238
Basal ganglion degeneration	24.97	12.98	13	92027	395	50512689
Leukoencephalopathy	24.94	12.98	33	92007	3850	50509234
Granulomatous liver disease	24.90	12.98	16	92024	727	50512357
Ventricular internal diameter abnormal	24.87	12.98	7	92033	34	50513050
Cytokine release syndrome	24.79	12.98	51	91989	8583	50504501
Osteoporosis	24.77	12.98	27	92013	44852	50468232
Type 2 diabetes mellitus	24.73	12.98	16	92024	34359	50478725
General physical health deterioration	24.72	12.98	380	91660	142054	50371030
Onycholysis	24.70	12.98	20	92020	1308	50511776
Dry mouth	24.68	12.98	40	92000	56138	50456946
Peripheral T-cell lymphoma unspecified	24.68	12.98	10	92030	167	50512917
Treatment noncompliance	24.61	12.98	12	92028	30138	50482946
Road traffic accident	24.39	12.98	7	92033	24345	50488739
Pulse waveform abnormal	24.20	12.98	8	92032	72	50513012
Ankle brachial index decreased	24.10	12.98	8	92032	73	50513011
Abdominal compartment syndrome	24.04	12.98	14	92026	532	50512552
Coronary artery disease	24.01	12.98	12	92028	29714	50483370
International normalised ratio increased	23.77	12.98	26	92014	43126	50469958
Carotid intima-media thickness increased	23.73	12.98	8	92032	77	50513007
Bacterial sepsis	23.67	12.98	31	92009	3581	50509503
Hyperferritinaemia	23.60	12.98	9	92031	127	50512957
Left atrial enlargement	23.58	12.98	11	92029	262	50512822
Mediastinitis	23.55	12.98	10	92030	189	50512895
Chronic obstructive pulmonary disease	23.52	12.98	38	92002	53397	50459687
Primary immunodeficiency syndrome	23.50	12.98	7	92033	43	50513041
Joint range of motion decreased	23.42	12.98	3	92037	18509	50494575
Osteolysis	23.40	12.98	26	92014	2531	50510553
Myeloproliferative neoplasm	23.34	12.98	13	92027	453	50512631
Ear infection	23.32	12.98	9	92031	25961	50487123
Klebsiella bacteraemia	23.26	12.98	19	92021	1258	50511826
Aggression	23.22	12.98	5	92035	21111	50491973
Abortion spontaneous	23.20	12.98	25	92015	41747	50471337
Increased liver stiffness	23.10	12.98	5	92035	5	50513079
Cardio-respiratory arrest	23.10	12.98	39	92001	53853	50459231
Deep vein thrombosis	23.05	12.98	219	91821	73085	50439999
Metastases to chest wall	23.03	12.98	13	92027	465	50512619
Fanconi syndrome	23.03	12.98	18	92022	1118	50511966
Dry eye	23.00	12.98	15	92025	32080	50481004
Abnormal behaviour	23.00	12.98	4	92036	19654	50493430
Disseminated intravascular coagulation	22.93	12.98	76	91964	17059	50496025
Refractory cytopenia with multilineage dysplasia	22.86	12.98	9	92031	139	50512945
Cardiac ventricular thrombosis	22.83	12.98	13	92027	473	50512611
Depressed level of consciousness	22.82	12.98	37	92003	51916	50461168
Rhinovirus infection	22.65	12.98	30	92010	3504	50509580
Swelling face	22.60	12.98	38	92002	52557	50460527
Proteinuria	22.55	12.98	74	91966	16523	50496561
Heart rate irregular	22.52	12.98	4	92036	19356	50493728
Large intestine perforation	22.38	12.98	45	91995	7449	50505635
Sleep disorder	22.28	12.98	44	91996	57239	50455845
Pseudocirrhosis	22.19	12.98	14	92026	616	50512468
Drug reaction with eosinophilia and systemic symptoms	22.18	12.98	12	92028	28412	50484672
Blood magnesium decreased	22.16	12.98	57	91983	11103	50501981
Hypoaesthesia	22.14	12.98	138	91902	127119	50385965
Acute biphenotypic leukaemia	22.12	12.98	7	92033	54	50513030
Crying	22.11	12.98	5	92035	20411	50492673
Joint ankylosis	22.08	12.98	15	92025	749	50512335
Candida infection	22.01	12.98	93	91947	23430	50489654
Sinus polyp	21.98	12.98	11	92029	307	50512777
Anastomotic leak	21.92	12.98	12	92028	404	50512680
Gait inability	21.89	12.98	21	92019	37006	50476078
Uterine enlargement	21.85	12.98	17	92023	1049	50512035
Metastases to pancreas	21.79	12.98	10	92030	229	50512855
Aspergillus infection	21.63	12.98	42	91998	6779	50506305
Non-cirrhotic portal hypertension	21.55	12.98	9	92031	163	50512921
Diabetes mellitus	21.46	12.98	35	92005	48998	50464086
Subdural hygroma	21.44	12.98	10	92030	238	50512846
Combined immunodeficiency	21.43	12.98	8	92032	106	50512978
BRCA2 gene mutation	21.28	12.98	7	92033	62	50513022
Mantle cell lymphoma	21.14	12.98	12	92028	434	50512650
Basal cell carcinoma	21.13	12.98	8	92032	23348	50489736
Nervousness	21.10	12.98	12	92028	27639	50485445
Amputation stump pain	21.01	12.98	6	92034	31	50513053
Dysplasia	21.01	12.98	14	92026	677	50512407
Acute monocytic leukaemia	20.89	12.98	7	92033	66	50513018
Gastric stenosis	20.89	12.98	7	92033	66	50513018
Hip arthroplasty	20.77	12.98	15	92025	30414	50482670
Drug clearance decreased	20.73	12.98	17	92023	1132	50511952
Colitis ulcerative	20.69	12.98	3	92037	16851	50496233
Paraparesis	20.66	12.98	22	92018	2042	50511042
Mucormycosis	20.61	12.98	24	92016	2459	50510625
Bone marrow infiltration	20.60	12.98	12	92028	456	50512628
Restlessness	20.58	12.98	10	92030	25163	50487921
Geotrichum infection	20.56	12.98	12	92028	458	50512626
Epstein-Barr virus associated lymphoproliferative disorder	20.54	12.98	20	92020	1669	50511415
Acute hepatic failure	20.50	12.98	69	91971	15608	50497476
Opsoclonus myoclonus	20.47	12.98	8	92032	121	50512963
Administration site extravasation	20.46	12.98	14	92026	707	50512377
Brain oedema	20.39	12.98	59	91981	12311	50500773
Cerebellar haemangioma	20.35	12.98	7	92033	72	50513012
Vulvovaginal inflammation	20.26	12.98	13	92027	589	50512495
Tumour necrosis	20.24	12.98	14	92026	720	50512364
Pharyngeal inflammation	20.07	12.98	13	92027	599	50512485
Liver function test abnormal	20.02	12.98	31	92009	44308	50468776
Blood pressure decreased	20.02	12.98	45	91995	55864	50457220
Toxic erythema of chemotherapy	20.00	12.98	8	92032	129	50512955
Mucoepidermoid carcinoma	19.98	12.98	6	92034	38	50513046
Duodenal stenosis	19.96	12.98	12	92028	484	50512600
Lip swelling	19.96	12.98	10	92030	24726	50488358
Sciatica	19.89	12.98	7	92033	21375	50491709
Dysaesthesia	19.89	12.98	29	92011	3706	50509378
Therapy interrupted	19.80	12.98	6	92034	20146	50492938
Eye swelling	19.79	12.98	6	92034	20138	50492946
Pulmonary vein stenosis	19.77	12.98	7	92033	79	50513005
Abdominal abscess	19.74	12.98	30	92010	3978	50509106
Respiratory distress	19.46	12.98	108	91932	30381	50482703
Eye pain	19.45	12.98	14	92026	28435	50484649
Red blood cell sedimentation rate increased	19.44	12.98	15	92025	29401	50483683
Acute respiratory distress syndrome	19.42	12.98	83	91957	21016	50492068
Jejunal stenosis	19.35	12.98	6	92034	43	50513041
Transaminases	19.30	12.98	7	92033	85	50512999
Dementia	19.28	12.98	3	92037	15994	50497090
Mood swings	19.21	12.98	3	92037	15951	50497133
Ovarian cancer	19.21	12.98	34	92006	5115	50507969
Prescribed underdose	19.21	12.98	3	92037	15946	50497138
Influenza like illness	19.18	12.98	48	91992	57411	50455673
Vulvovaginitis	19.17	12.98	10	92030	305	50512779
Weight decreased	19.16	12.98	285	91755	220960	50292124
Leukaemia cutis	19.08	12.98	7	92033	88	50512996
PIK3CA-activated mutation	19.00	12.98	14	92026	796	50512288
Pleuroparenchymal fibroelastosis	18.96	12.98	5	92035	18	50513066
Small intestinal perforation	18.92	12.98	17	92023	1281	50511803
Mitral valve disease	18.90	12.98	21	92019	2045	50511039
Peritonitis viral	18.77	12.98	6	92034	48	50513036
Breast neoplasm	18.76	12.98	17	92023	1296	50511788
Atypical haemolytic uraemic syndrome	18.68	12.98	12	92028	545	50512539
Cytomegalovirus chorioretinitis	18.62	12.98	18	92022	1489	50511595
Subileus	18.58	12.98	24	92016	2735	50510349
Panic attack	18.57	12.98	6	92034	19336	50493748
Chronic hepatitis	18.54	12.98	14	92026	826	50512258
Human rhinovirus test positive	18.52	12.98	8	92032	158	50512926
Neonatal lupus erythematosus	18.48	12.98	4	92036	4	50513080
Serotonin syndrome	18.47	12.98	11	92029	24702	50488382
Intervertebral disc protrusion	18.42	12.98	7	92033	20386	50492698
Bradycardia	18.41	12.98	58	91982	64368	50448716
Staphylococcal sepsis	18.39	12.98	40	92000	6996	50506088
Osteosarcoma metastatic	18.35	12.98	5	92035	21	50513063
Paranasal sinus mucosal hypertrophy	18.35	12.98	5	92035	21	50513063
Malignant ascites	18.35	12.98	14	92026	839	50512245
Gallbladder disorder	18.34	12.98	4	92036	16738	50496346
Liver function test increased	18.31	12.98	12	92028	25594	50487490
Tendonitis	18.28	12.98	4	92036	16701	50496383
Atrial fibrillation	18.25	12.98	273	91767	101472	50411612
Enterocutaneous fistula	18.24	12.98	16	92024	1168	50511916
Diarrhoea haemorrhagic	18.23	12.98	42	91998	7633	50505451
Renal disorder	18.20	12.98	14	92026	27491	50485593
Fungal oesophagitis	18.20	12.98	12	92028	570	50512514
Central nervous system enteroviral infection	18.17	12.98	5	92035	22	50513062
Liver abscess	18.16	12.98	23	92017	2570	50510514
Infection	18.12	12.98	427	91613	172527	50340557
Triple negative breast cancer	18.09	12.98	7	92033	103	50512981
Femur fracture	18.08	12.98	25	92015	37439	50475645
Dysstasia	18.07	12.98	5	92035	17814	50495270
Secondary cerebellar degeneration	17.96	12.98	6	92034	56	50513028
Enterocolitis	17.93	12.98	38	92002	6529	50506555
Anaesthesia	17.92	12.98	10	92030	350	50512734
Inflammation	17.88	12.98	49	91991	56863	50456221
Tooth disorder	17.81	12.98	11	92029	24217	50488867
Urethritis	17.67	12.98	9	92031	261	50512823
Inflammatory myofibroblastic tumour	17.64	12.98	5	92035	25	50513059
Product prescribing error	17.64	12.98	8	92032	20953	50492131
Hormone receptor positive breast cancer	17.62	12.98	11	92029	475	50512609
Head injury	17.52	12.98	11	92029	24009	50489075
Therapy cessation	17.52	12.98	13	92027	25998	50487086
Acute pulmonary oedema	17.52	12.98	40	92000	7227	50505857
Drug dependence	17.49	12.98	7	92033	19752	50493332
Injection site rash	17.44	12.98	4	92036	16173	50496911
Hip fracture	17.42	12.98	13	92027	25918	50487166
Lactic acidosis	17.40	12.98	21	92019	33334	50479750
Pneumonia	17.40	12.98	848	91192	377553	50135531
Oesophageal candidiasis	17.38	12.98	32	92008	4962	50508122
Synovial sarcoma	17.33	12.98	5	92035	27	50513057
Artificial menopause	17.33	12.98	5	92035	27	50513057
Nightmare	17.30	12.98	4	92036	16082	50497002
Trichodysplasia spinulosa	17.29	12.98	11	92029	491	50512593
Rhinorrhoea	17.29	12.98	43	91997	51540	50461544
Vomiting	17.28	12.98	1013	91027	459745	50053339
Sarcoidosis	17.28	12.98	32	92008	4985	50508099
Oral fungal infection	17.27	12.98	22	92018	2473	50510611
Primary mediastinal large B-cell lymphoma recurrent	17.25	12.98	6	92034	64	50513020
Sinus disorder	17.24	12.98	6	92034	18452	50494632
Cardiac tamponade	17.17	12.98	29	92011	4203	50508881
Accidental overdose	17.16	12.98	7	92033	19526	50493558
Pneumonia influenzal	17.15	12.98	17	92023	1450	50511634
Seasonal allergy	17.14	12.98	3	92037	14673	50498411
Hyperbilirubinaemia	17.10	12.98	47	91993	9523	50503561
Abdominal neoplasm	17.09	12.98	9	92031	280	50512804
Stem cell transplant	17.09	12.98	18	92022	1650	50511434
Eye irritation	17.03	12.98	5	92035	17135	50495949
Myasthenic syndrome	17.01	12.98	8	92032	194	50512890
Device dislocation	16.95	12.98	9	92031	21537	50491547
Herpes zoster meningoencephalitis	16.94	12.98	9	92031	285	50512799
Mediastinum neoplasm	16.92	12.98	6	92034	68	50513016
Rectal fissure	16.82	12.98	11	92029	515	50512569
Disorientation	16.81	12.98	24	92016	35460	50477624
Orthopnoea	16.80	12.98	34	92006	5655	50507429
Glaucoma	16.67	12.98	4	92036	15682	50497402
Atrial flutter	16.62	12.98	44	91996	8719	50504365
Metastases to abdominal cavity	16.55	12.98	10	92030	407	50512677
Ventricular remodelling	16.55	12.98	4	92036	9	50513075
Failure to thrive	16.45	12.98	36	92004	6322	50506762
Heavy menstrual bleeding	16.44	12.98	4	92036	15533	50497551
Pleural disorder	16.41	12.98	11	92029	537	50512547
Venous thrombosis limb	16.41	12.98	22	92018	2600	50510484
Toxic encephalopathy	16.33	12.98	33	92007	5482	50507602
Granulocytopenia	16.33	12.98	32	92008	5199	50507885
Poor quality sleep	16.28	12.98	5	92035	16641	50496443
Febrile infection	16.27	12.98	15	92025	1169	50511915
BK virus infection	16.26	12.98	23	92017	2858	50510226
Jejunal ulcer perforation	16.22	12.98	5	92035	35	50513049
Granulomatous pneumonitis	16.22	12.98	5	92035	35	50513049
Enterovirus test positive	16.22	12.98	7	92033	138	50512946
Lung disorder	16.21	12.98	138	91902	44661	50468423
Portal hypertension	16.15	12.98	25	92015	3367	50509717
Haematoma	16.14	12.98	19	92021	30491	50482593
VIth nerve paresis	16.11	12.98	6	92034	79	50513005
Renal tubular disorder	16.10	12.98	21	92019	2416	50510668
Pregnancy	16.10	12.98	18	92022	29559	50483525
Antithrombin III decreased	16.09	12.98	8	92032	220	50512864
Transient ischaemic attack	16.05	12.98	21	92019	32189	50480895
Acute hepatitis C	16.04	12.98	6	92034	80	50513004
Low birth weight baby	16.02	12.98	34	92006	5847	50507237
Movement disorder	16.02	12.98	6	92034	17626	50495458
Kidney infection	16.02	12.98	7	92033	18739	50494345
Aplastic anaemia	15.98	12.98	40	92000	7663	50505421
Fungaemia	15.96	12.98	19	92021	1993	50511091
Lethargy	15.95	12.98	42	91998	49390	50463694
Mucoepidermoid carcinoma of salivary gland	15.93	12.98	3	92037	0	50513084
Maternal exposure during pregnancy	15.92	12.98	200	91840	159578	50353506
Intestinal obstruction	15.88	12.98	92	91948	26291	50486793
Syphilis	15.81	12.98	7	92033	147	50512937
Meningitis streptococcal	15.81	12.98	7	92033	147	50512937
Cholelithiasis	15.79	12.98	28	92012	37945	50475139
Leukoplakia oral	15.72	12.98	7	92033	149	50512935
Cytology abnormal	15.72	12.98	4	92036	12	50513072
Thrombophlebitis	15.72	12.98	27	92013	3966	50509118
Salmonella sepsis	15.70	12.98	8	92032	232	50512852
Neurological decompensation	15.69	12.98	20	92020	2250	50510834
Dermatitis bullous	15.68	12.98	38	92002	7135	50505949
Pleural neoplasm	15.67	12.98	8	92032	233	50512851
Pyloric stenosis	15.65	12.98	9	92031	334	50512750
Blood stem cell transplant failure	15.64	12.98	7	92033	151	50512933
Metastases to retroperitoneum	15.51	12.98	7	92033	154	50512930
Faeces discoloured	15.48	12.98	5	92035	16119	50496965
Acral peeling skin syndrome	15.48	12.98	4	92036	13	50513071
Metastases to ovary	15.48	12.98	9	92031	341	50512743
Hypersensitivity pneumonitis	15.33	12.98	20	92020	2302	50510782
Pulmonary artery stenosis	15.27	12.98	7	92033	160	50512924
Oedema peripheral	15.27	12.98	199	91841	157762	50355322
Pulmonary mass	15.26	12.98	71	91969	18634	50494450
Vessel puncture site bruise	15.22	12.98	9	92031	352	50512732
Tumour marker increased	15.16	12.98	26	92014	3814	50509270
Depressed mood	15.16	12.98	24	92016	33999	50479085
Rash erythematous	15.14	12.98	25	92015	34827	50478257
Laboratory test abnormal	15.12	12.98	12	92028	23196	50489888
Sputum discoloured	15.08	12.98	3	92037	13392	50499692
Listeria encephalitis	14.99	12.98	8	92032	256	50512828
Acute erythroid leukaemia	14.93	12.98	5	92035	47	50513037
Haemorrhage intracranial	14.91	12.98	53	91987	12321	50500763
Carbohydrate antigen 15-3 increased	14.90	12.98	14	92026	1118	50511966
Pulmonary haemorrhage	14.84	12.98	35	92005	6457	50506627
Beta 2 microglobulin decreased	14.84	12.98	4	92036	16	50513068
Necrosis	14.82	12.98	29	92011	4707	50508377
Venous thrombosis	14.78	12.98	28	92012	4438	50508646
Throat irritation	14.77	12.98	20	92020	30219	50482865
Rhabdomyosarcoma	14.77	12.98	6	92034	101	50512983
IIIrd nerve paralysis	14.76	12.98	11	92029	636	50512448
Blood potassium decreased	14.69	12.98	28	92012	36917	50476167
Diabetes mellitus inadequate control	14.68	12.98	3	92037	13142	50499942
Medication error	14.68	12.98	27	92013	36077	50477007
Cerebral haemangioma	14.66	12.98	6	92034	103	50512981
Metastases to vagina	14.64	12.98	4	92036	17	50513067
Necrotising colitis	14.62	12.98	10	92030	505	50512579
Pseudomonas infection	14.61	12.98	44	91996	9386	50503698
Hypoglossal nerve paresis	14.50	12.98	6	92034	106	50512978
Joint effusion	14.49	12.98	3	92037	13018	50500066
B-lymphocyte count abnormal	14.48	12.98	5	92035	52	50513032
Epstein Barr virus positive mucocutaneous ulcer	14.47	12.98	9	92031	386	50512698
Eczema	14.47	12.98	12	92028	22690	50490394
Right ventricular dysfunction	14.45	12.98	16	92024	1552	50511532
Chronic hepatitis B	14.44	12.98	7	92033	182	50512902
Alopecia areata	14.44	12.98	15	92025	1353	50511731
Retroperitoneal mass	14.40	12.98	6	92034	108	50512976
Respiratory tract congestion	14.37	12.98	4	92036	14195	50498889
Hepatic lesion	14.35	12.98	26	92014	3982	50509102
Skin mass	14.35	12.98	30	92010	5105	50507979
Tachycardia induced cardiomyopathy	14.32	12.98	5	92035	54	50513030
Ocular lymphoma	14.32	12.98	5	92035	54	50513030
Photosensitivity reaction	14.31	12.98	3	92037	12908	50500176
Metastases to stomach	14.30	12.98	7	92033	186	50512898
Subclavian vein thrombosis	14.29	12.98	17	92023	1782	50511302
Metastatic neoplasm	14.28	12.98	25	92015	3729	50509355
Diverticulitis	14.23	12.98	24	92016	33158	50479926
Hypokalaemia	14.21	12.98	232	91808	87760	50425324
Encephalitis viral	14.21	12.98	16	92024	1581	50511503
Sneezing	14.13	12.98	4	92036	14040	50499044
Malignant neoplasm of orbit	14.12	12.98	4	92036	20	50513064
Lymphadenopathy mediastinal	14.11	12.98	20	92020	2491	50510593
Dermatitis allergic	14.01	12.98	3	92037	12717	50500367
Chronic myelomonocytic leukaemia	13.95	12.98	8	92032	295	50512789
Vascular compression	13.91	12.98	6	92034	118	50512966
Orthostatic hypotension	13.90	12.98	20	92020	29461	50483623
Obliterative bronchiolitis	13.88	12.98	17	92023	1836	50511248
Chondrosarcoma metastatic	13.86	12.98	3	92037	3	50513081
Lung adenocarcinoma	13.78	12.98	26	92014	4108	50508976
Thrombocytopenic purpura	13.76	12.98	14	92026	1232	50511852
Leukaemia recurrent	13.69	12.98	14	92026	1240	50511844
Feeling hot	13.67	12.98	32	92008	39170	50473914
Hepatic calcification	13.65	12.98	4	92036	23	50513061
Peripheral sensorimotor neuropathy	13.61	12.98	14	92026	1248	50511836
Adverse event	13.51	12.98	38	92002	43725	50469359
Hepatitis C RNA increased	13.51	12.98	6	92034	127	50512957
Restless legs syndrome	13.48	12.98	6	92034	15891	50497193
Upper limb fracture	13.45	12.98	6	92034	15867	50497217
Peritoneal disorder	13.43	12.98	9	92031	439	50512645
Lymphoproliferative disorder	13.42	12.98	21	92019	2856	50510228
Mucosal erosion	13.38	12.98	14	92026	1273	50511811
Hydronephrosis	13.37	12.98	40	92000	8501	50504583
Mediastinal fibrosis	13.37	12.98	4	92036	25	50513059
Lymph node pain	13.31	12.98	14	92026	1281	50511803
Coronary ostial stenosis	13.28	12.98	5	92035	68	50513016
Pneumonia cytomegaloviral	13.25	12.98	17	92023	1924	50511160
Hyperkalaemia	13.24	12.98	44	91996	48045	50465039
Corneal graft rejection	13.23	12.98	4	92036	26	50513058
Spinal cord compression	13.21	12.98	24	92016	3685	50509399
Sinus tachycardia	13.20	12.98	75	91965	21279	50491805
Chemotherapeutic drug level increased	13.17	12.98	6	92034	135	50512949
Cyst	13.17	12.98	3	92037	12184	50500900
Paronychia	13.15	12.98	27	92013	4537	50508547
Tachypnoea	13.15	12.98	57	91983	14520	50498564
Bladder perforation	13.13	12.98	6	92034	136	50512948
Rectal haemorrhage	13.03	12.98	32	92008	38526	50474558
Ventricular asystole	13.02	12.98	5	92035	72	50513012
Postictal state	12.99	12.98	12	92028	938	50512146

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	3347.88	13.36	2480	67928	109760	29394359
Neutropenia	1146.26	13.36	1484	68924	130227	29373892
Product use in unapproved indication	935.73	13.36	1091	69317	85784	29418335
Off label use	815.86	13.36	2032	68376	298768	29205351
Diffuse large B-cell lymphoma recurrent	590.25	13.36	225	70183	2372	29501747
Mucosal inflammation	585.43	13.36	532	69876	31063	29473056
Hepatitis B	554.75	13.36	268	70140	5229	29498890
Second primary malignancy	552.92	13.36	285	70123	6420	29497699
Haematotoxicity	530.18	13.36	277	70131	6422	29497697
Cardiotoxicity	486.91	13.36	234	70174	4510	29499609
Myelosuppression	467.26	13.36	316	70092	11911	29492208
Myelodysplastic syndrome	462.03	13.36	364	70044	17430	29486689
Acute myeloid leukaemia	437.80	13.36	342	70066	16171	29487948
Hepatitis B reactivation	417.73	13.36	187	70221	3042	29501077
Bone marrow failure	403.62	13.36	407	70001	27042	29477077
Disease progression	397.88	13.36	705	69703	81211	29422908
Tumour lysis syndrome	334.75	13.36	272	70136	13612	29490507
Pancytopenia	297.37	13.36	629	69779	82539	29421580
Thrombocytopenia	291.99	13.36	841	69567	133982	29370137
Febrile bone marrow aplasia	264.24	13.36	183	70225	7168	29496951
Pneumocystis jirovecii pneumonia	245.08	13.36	248	70160	16531	29487588
Neutropenic sepsis	233.85	13.36	206	70202	11521	29492598
Leukopenia	232.33	13.36	447	69961	54756	29449363
Neutrophil count decreased	228.19	13.36	388	70020	43179	29460940
Progressive multifocal leukoencephalopathy	221.14	13.36	176	70232	8543	29495576
Cytomegalovirus chorioretinitis	217.22	13.36	120	70288	3118	29501001
Acquired gene mutation	215.91	13.36	89	70319	1169	29502950
Diffuse large B-cell lymphoma refractory	209.91	13.36	80	70328	842	29503277
Therapy partial responder	209.68	13.36	139	70269	5060	29499059
Cytopenia	198.20	13.36	174	70234	9685	29494434
Fall	195.12	13.36	89	70319	177089	29327030
Product dose omission issue	185.38	13.36	11	70397	96372	29407747
Neoplasm progression	183.52	13.36	224	70184	18388	29485731
Pyrexia	173.19	13.36	1223	69185	286399	29217720
Septic shock	161.78	13.36	417	69991	62143	29441976
Posterior reversible encephalopathy syndrome	159.90	13.36	148	70260	8828	29495291
Mantle cell lymphoma recurrent	157.25	13.36	55	70353	443	29503676
B-cell lymphoma recurrent	152.49	13.36	57	70351	566	29503553
Cardiomyopathy	137.78	13.36	173	70235	14614	29489505
Rash	132.75	13.36	154	70254	189665	29314454
Malignant neoplasm progression	132.62	13.36	432	69976	73427	29430692
Neuropathy peripheral	131.66	13.36	420	69988	70607	29433512
Dizziness	131.46	13.36	155	70253	189529	29314590
Sepsis	129.01	13.36	675	69733	142007	29362112
Myocardial infarction	128.33	13.36	51	70357	110245	29393874
Arthralgia	123.92	13.36	91	70317	139526	29364593
Polyneuropathy	122.62	13.36	148	70260	12004	29492115
Lymphadenopathy	120.52	13.36	215	70193	24834	29479285
Anxiety	117.98	13.36	29	70379	85336	29418783
Ejection fraction decreased	110.88	13.36	162	70246	15816	29488303
Diffuse large B-cell lymphoma	110.85	13.36	103	70305	6173	29497946
Cytomegalovirus infection	110.08	13.36	198	70210	23017	29481102
Pain	103.52	13.36	155	70253	171277	29332842
Rhabdomyolysis	100.56	13.36	13	70395	60795	29443324
Muscle spasms	100.51	13.36	17	70391	65065	29439054
Death	100.22	13.36	447	69961	341637	29162482
Disease recurrence	98.55	13.36	153	70255	15761	29488358
Hypogammaglobulinaemia	96.79	13.36	93	70315	5814	29498305
Drug interaction	96.20	13.36	204	70204	197181	29306938
Herpes simplex	95.67	13.36	85	70323	4805	29499314
Neoplasm recurrence	94.91	13.36	59	70349	1918	29502201
White blood cell count decreased	92.92	13.36	419	69989	82943	29421176
Pruritus	92.67	13.36	85	70323	116764	29387355
Sweat gland tumour	91.10	13.36	35	70373	377	29503742
Anaemia	90.47	13.36	800	69608	200151	29303968
Somnolence	90.33	13.36	56	70352	93899	29410220
Weight increased	89.87	13.36	35	70373	76632	29427487
Blood pressure increased	89.35	13.36	32	70376	73771	29430348
Lymphopenia	89.28	13.36	134	70274	13399	29490720
Joint swelling	88.70	13.36	8	70400	49622	29454497
Myalgia	88.08	13.36	33	70375	73986	29430133
Drug resistance	87.54	13.36	172	70236	21368	29482751
Peripheral swelling	87.38	13.36	22	70386	63717	29440402
Feeling abnormal	86.82	13.36	13	70395	54432	29449687
Fatigue	86.23	13.36	425	69983	316396	29187723
Hepatic failure	85.48	13.36	214	70194	31298	29472821
Insomnia	85.19	13.36	53	70355	88708	29415411
Headache	84.61	13.36	180	70228	173827	29330292
Overdose	83.28	13.36	43	70365	79776	29424343
Depression	81.50	13.36	51	70357	85096	29419023
Tremor	80.70	13.36	37	70371	73501	29430618
Venoocclusive liver disease	79.37	13.36	90	70318	6827	29497292
Product use issue	79.22	13.36	286	70122	51158	29452961
Epstein-Barr virus infection	79.05	13.36	88	70320	6541	29497578
Pain in extremity	78.81	13.36	88	70320	110345	29393774
Dyspnoea	78.53	13.36	457	69951	326275	29177844
Malaise	77.66	13.36	165	70243	159437	29344682
Drug hypersensitivity	77.30	13.36	33	70375	68373	29435746
Blood glucose increased	75.91	13.36	23	70385	58961	29445158
Azoospermia	74.10	13.36	30	70378	375	29503744
Confusional state	73.90	13.36	119	70289	127758	29376361
End stage renal disease	73.51	13.36	91	70317	7573	29496546
Left ventricular dysfunction	73.30	13.36	98	70310	8804	29495315
Aspergillus infection	73	13.36	107	70301	10474	29493645
Cytokine release syndrome	71.47	13.36	119	70289	13000	29491119
Anaplastic lymphoma kinase gene mutation	69.88	13.36	21	70387	97	29504022
Cerebrovascular accident	69.64	13.36	49	70359	76862	29427257
Intentional product misuse	69.62	13.36	3	70405	34658	29469461
Candida infection	68.54	13.36	127	70281	15098	29489021
Stomatitis	67.36	13.36	218	70190	36895	29467224
Viral haemorrhagic cystitis	66.25	13.36	36	70372	904	29503215
Myelopathy	65.94	13.36	47	70361	1927	29502192
Aggression	65.51	13.36	5	70403	35536	29468583
Pneumonitis	65.38	13.36	180	70228	27864	29476255
Hospitalisation	64.73	13.36	15	70393	45973	29458146
Neurotoxicity	64.67	13.36	121	70287	14492	29489627
Blood creatine phosphokinase increased	64.12	13.36	10	70398	40634	29463485
Haemophagocytic lymphohistiocytosis	63.65	13.36	100	70308	10404	29493715
Bradycardia	63.21	13.36	39	70369	65590	29438529
Peripheral sensory neuropathy	62.64	13.36	74	70334	5865	29498254
Suicide attempt	62.31	13.36	5	70403	34105	29470014
Chest pain	61.17	13.36	108	70300	111865	29392254
Osteonecrosis	61.15	13.36	113	70295	13406	29490713
Coronary artery disease	61.04	13.36	15	70393	44175	29459944
Rheumatoid arthritis	60.78	13.36	4	70404	32148	29471971
Post transplant lymphoproliferative disorder	60.53	13.36	70	70338	5423	29498696
Venoocclusive disease	59.60	13.36	49	70359	2490	29501629
Hallucination	58.32	13.36	17	70391	44695	29459424
Musculoskeletal stiffness	57.34	13.36	10	70398	37448	29466671
Traumatic lung injury	56.10	13.36	35	70373	1145	29502974
Hypoglycaemia	55.12	13.36	23	70385	48323	29455796
Inappropriate schedule of product administration	54.29	13.36	19	70389	44453	29459666
JC virus infection	53.97	13.36	41	70367	1856	29502263
Multiple organ dysfunction syndrome	53.74	13.36	294	70114	62822	29441297
Escherichia sepsis	53.35	13.36	56	70352	3893	29500226
Salivary gland cancer	52.86	13.36	21	70387	249	29503870
Cystitis haemorrhagic	52.18	13.36	61	70347	4781	29499338
Central nervous system lymphoma	51.43	13.36	28	70380	706	29503413
Strongyloidiasis	50.91	13.36	43	70365	2269	29501850
Malignant transformation	50.75	13.36	29	70379	805	29503314
Bronchopulmonary aspergillosis	50.66	13.36	99	70309	12245	29491874
Nasopharyngitis	50.17	13.36	41	70367	59624	29444495
Chloroma	49.93	13.36	24	70384	462	29503657
B-cell lymphoma refractory	49.71	13.36	17	70391	127	29503992
Back pain	49.48	13.36	106	70302	102178	29401941
Post embolisation syndrome	48.40	13.36	14	70394	55	29504064
Pneumonia klebsiella	47.86	13.36	44	70364	2600	29501519
Chronic obstructive pulmonary disease	47.47	13.36	19	70389	40936	29463183
Refractory cancer	46.62	13.36	16	70392	121	29503998
Intestinal perforation	46.27	13.36	75	70333	8011	29496108
Acute lymphocytic leukaemia	46.11	13.36	43	70365	2588	29501531
Contusion	46.09	13.36	9	70399	31086	29473033
Neutropenic colitis	45.36	13.36	41	70367	2370	29501749
Gene mutation	44.82	13.36	29	70379	1012	29503107
Cardio-respiratory arrest	44.79	13.36	33	70375	50568	29453551
Escherichia infection	44.64	13.36	67	70341	6697	29497422
Hyperhidrosis	44.31	13.36	53	70355	64487	29439632
Incorrect dose administered	44.01	13.36	12	70396	32972	29471147
Infection	43.87	13.36	323	70085	76428	29427691
Nephropathy toxic	43.82	13.36	86	70322	10670	29493449
Memory impairment	43.80	13.36	16	70392	36454	29467665
Gastritis bacterial	43.77	13.36	17	70391	189	29503930
Infection reactivation	43.67	13.36	29	70379	1058	29503061
Fungal infection	43.64	13.36	99	70309	13586	29490533
Agitation	43.45	13.36	35	70373	51269	29452850
Abnormal behaviour	43.35	13.36	3	70405	23124	29480995
Interstitial lung disease	43.32	13.36	260	70148	57458	29446661
Administration site extravasation	43.28	13.36	22	70386	480	29503639
Lymphoma transformation	43.06	13.36	16	70392	156	29503963
Injection site pain	42.93	13.36	12	70396	32434	29471685
Wheezing	42.69	13.36	13	70395	33227	29470892
Psoriasis	42.49	13.36	12	70396	32215	29471904
Oedema peripheral	42.45	13.36	117	70291	103440	29400679
Lung infiltration	41.86	13.36	89	70319	11690	29492429
Gait disturbance	41.63	13.36	69	70339	73280	29430839
Abdominal discomfort	41.42	13.36	32	70376	47871	29456248
Sleep disorder	40.82	13.36	5	70403	24381	29479738
Loss of consciousness	40.81	13.36	71	70337	73985	29430134
Congenital cardiovascular anomaly	40.79	13.36	16	70392	183	29503936
Cytogenetic abnormality	40.73	13.36	25	70383	794	29503325
Loss of personal independence in daily activities	40.71	13.36	6	70402	25434	29478685
Nephrolithiasis	40.49	13.36	6	70402	25328	29478791
Asthma	40.40	13.36	15	70393	33834	29470285
Peripheral T-cell lymphoma unspecified	40.25	13.36	20	70388	415	29503704
Aplasia	40.19	13.36	49	70359	4014	29500105
Colitis	40.09	13.36	164	70244	31084	29473035
Heart rate decreased	39.58	13.36	6	70402	24906	29479213
Autoimmune neutropenia	39.02	13.36	17	70391	258	29503861
Urticaria	38.47	13.36	44	70364	54616	29449503
Blood stem cell transplant failure	38.04	13.36	19	70389	399	29503720
Diarrhoea	37.94	13.36	561	69847	332137	29171982
Unevaluable event	37.75	13.36	12	70396	29839	29474280
BK virus infection	37.50	13.36	51	70357	4656	29499463
Staphylococcal sepsis	37.50	13.36	72	70336	8790	29495329
Platelet count decreased	36.31	13.36	395	70013	104277	29399842
Retinal haemorrhage	36.19	13.36	49	70359	4455	29499664
Endocarditis noninfective	36.10	13.36	13	70395	115	29504004
Agranulocytosis	35.56	13.36	118	70290	20222	29483897
Osteosarcoma recurrent	34.90	13.36	9	70399	20	29504099
Arthropathy	34.69	13.36	5	70403	21549	29482570
Congestive cardiomyopathy	34.59	13.36	59	70349	6571	29497548
Bacteraemia	34.36	13.36	101	70307	16222	29487897
Injury	34.21	13.36	3	70405	19043	29485076
Balance disorder	34.12	13.36	22	70386	36148	29467971
Transformation to acute myeloid leukaemia	34.02	13.36	21	70387	674	29503445
Chronic myeloid leukaemia	33.82	13.36	32	70376	1962	29502157
Therapy non-responder	33.36	13.36	154	70254	30757	29473362
Device related thrombosis	33.10	13.36	23	70385	905	29503214
Ganglioneuroblastoma	32.97	13.36	9	70399	27	29504092
Pseudomonas infection	32.94	13.36	77	70331	10775	29493344
Autoimmune lymphoproliferative syndrome	32.81	13.36	13	70395	153	29503966
Haemoglobin abnormal	32.70	13.36	39	70369	3122	29500997
Syncope	32.55	13.36	93	70315	81278	29422841
Cardiac failure congestive	32.52	13.36	85	70323	76496	29427623
Cytomegalovirus infection reactivation	32.35	13.36	40	70368	3324	29500795
Epstein-Barr virus associated lymphoma	32.20	13.36	19	70389	561	29503558
Angioedema	32.08	13.36	18	70390	31897	29472222
Hyperkalaemia	31.91	13.36	61	70347	61331	29442788
Hepatic fibrosis	31.81	13.36	39	70369	3213	29500906
Mobility decreased	31.48	13.36	11	70397	25769	29478350
Subdural hygroma	31.43	13.36	15	70393	284	29503835
Glioma	31.34	13.36	15	70393	286	29503833
Cardiac arrest	31.26	13.36	102	70306	85489	29418630
Lymphoma	31.23	13.36	71	70337	9757	29494362
Heart rate increased	31.21	13.36	28	70380	38910	29465209
Acute lymphocytic leukaemia recurrent	31.03	13.36	34	70374	2482	29501637
International normalised ratio increased	30.92	13.36	36	70372	44336	29459783
Vision blurred	30.89	13.36	30	70378	40146	29463973
5q minus syndrome	30.77	13.36	12	70396	135	29503984
Pneumothorax spontaneous	30.71	13.36	16	70392	368	29503751
Respiratory failure	30.71	13.36	360	70048	96771	29407348
Peripheral motor neuropathy	30.71	13.36	28	70380	1637	29502482
Recurrent cancer	30.57	13.36	24	70384	1141	29502978
Mass	30.36	13.36	58	70350	7053	29497066
Hepatosplenic candidiasis	30.28	13.36	13	70395	190	29503929
Chest discomfort	30.26	13.36	39	70369	45944	29458175
Gastrointestinal toxicity	30.19	13.36	31	70377	2100	29502019
Toxic erythema of chemotherapy	30.05	13.36	10	70398	68	29504051
Pneumonia	29.62	13.36	983	69425	319189	29184930
Device related infection	29.40	13.36	93	70315	15543	29488576
Viral load increased	29.38	13.36	30	70378	2019	29502100
Drug withdrawal syndrome	29.34	13.36	4	70404	17980	29486139
Haematochezia	29.16	13.36	27	70381	36956	29467163
Klebsiella infection	29.02	13.36	58	70350	7291	29496828
Blood HIV RNA increased	28.84	13.36	22	70386	1002	29503117
Cardiomyopathy acute	28.83	13.36	8	70400	26	29504093
Metastases to lung	28.66	13.36	60	70348	7795	29496324
Renal tubular disorder	28.57	13.36	43	70365	4309	29499810
Splenic lesion	28.26	13.36	11	70397	123	29503996
Drug clearance decreased	28.25	13.36	25	70383	1405	29502714
Herpes simplex encephalitis	28.16	13.36	14	70394	291	29503828
Metastases to spleen	28.03	13.36	15	70393	365	29503754
Abdominal pain upper	28.01	13.36	65	70343	60928	29443191
Gastric perforation	27.76	13.36	30	70378	2156	29501963
Tidal volume decreased	27.54	13.36	8	70400	32	29504087
Skin toxicity	27.27	13.36	39	70369	3732	29500387
Mucosal toxicity	27.26	13.36	12	70396	187	29503932
Pneumonia fungal	27.02	13.36	49	70359	5728	29498391
Primitive neuroectodermal tumour	26.94	13.36	9	70399	62	29504057
Toxicity to various agents	26.86	13.36	274	70134	173387	29330732
Respiratory arrest	26.80	13.36	14	70394	25819	29478300
Blood cholesterol increased	26.59	13.36	3	70405	15592	29488527
Encephalitis enteroviral	26.58	13.36	11	70397	146	29503973
Road traffic accident	26.51	13.36	3	70405	15558	29488561
Disorientation	26.44	13.36	19	70389	29496	29474623
Ototoxicity	26.32	13.36	25	70383	1540	29502579
Accidental overdose	26.27	13.36	5	70403	17588	29486531
Ill-defined disorder	26.26	13.36	74	70334	11604	29492515
Pulmonary toxicity	26.15	13.36	44	70364	4846	29499273
Secondary immunodeficiency	26.15	13.36	14	70394	341	29503778
Gastrooesophageal reflux disease	26.03	13.36	22	70386	31474	29472645
Hypertriglyceridaemia	26.00	13.36	56	70352	7419	29496700
Haemorrhage	25.94	13.36	42	70366	45030	29459089
Plasmacytoma	25.86	13.36	35	70373	3180	29500939
Hypertension	25.83	13.36	167	70241	116447	29387672
Intestinal atresia	25.78	13.36	9	70399	72	29504047
Metastases to retroperitoneum	25.75	13.36	12	70396	215	29503904
Myelitis transverse	25.58	13.36	20	70388	945	29503174
West Nile viral infection	25.29	13.36	17	70391	633	29503486
Chylothorax	25.22	13.36	17	70391	636	29503483
Biliary-bronchial fistula	25.21	13.36	5	70403	0	29504119
Cardiac dysfunction	25.08	13.36	26	70382	1781	29502338
Peripheral sensorimotor neuropathy	25.06	13.36	23	70385	1356	29502763
Gastrointestinal haemorrhage	24.93	13.36	101	70307	79432	29424687
Product quality issue	24.86	13.36	4	70404	15891	29488228
Hepatic infection fungal	24.73	13.36	11	70397	176	29503943
Refractory anaemia with an excess of blasts	24.68	13.36	14	70394	383	29503736
Cardiac failure	24.67	13.36	293	70115	78994	29425125
Cerebral toxoplasmosis	24.54	13.36	23	70385	1393	29502726
Irritability	24.51	13.36	11	70397	22141	29481978
Mucormycosis	24.44	13.36	44	70364	5114	29499005
Cellulitis gangrenous	24.39	13.36	11	70397	182	29503937
Psychotic disorder	24.32	13.36	9	70399	20345	29483774
Pleural effusion	24.28	13.36	270	70138	71638	29432481
Testicular disorder	24.28	13.36	16	70392	576	29503543
Cardiac disorder	24.11	13.36	32	70376	37231	29466888
Depressed mood	23.88	13.36	5	70403	16443	29487676
Osteosarcoma	23.86	13.36	11	70397	192	29503927
Molluscum contagiosum	23.81	13.36	12	70396	257	29503862
Hypersensitivity	23.79	13.36	57	70351	52846	29451273
Blood pressure decreased	23.79	13.36	45	70363	45432	29458687
Weight decreased	23.78	13.36	237	70171	150668	29353451
Acute lymphocytic leukaemia refractory	23.67	13.36	9	70399	94	29504025
Meningitis cryptococcal	23.54	13.36	27	70381	2073	29502046
Meningitis tuberculous	23.49	13.36	16	70392	609	29503510
Pulmonary sarcoidosis	23.47	13.36	15	70393	512	29503607
Neurofibrosarcoma	23.35	13.36	7	70401	32	29504087
Head injury	23.11	13.36	5	70403	16076	29488043
Metastases to muscle	22.97	13.36	11	70397	210	29503909
Escherichia bacteraemia	22.82	13.36	31	70377	2827	29501292
Unresponsive to stimuli	22.73	13.36	16	70392	25110	29479009
Palmar-plantar erythrodysaesthesia syndrome	22.65	13.36	82	70326	14677	29489442
Drug reaction with eosinophilia and systemic symptoms	22.58	13.36	20	70388	27972	29476147
Lentigo	22.52	13.36	13	70395	368	29503751
Morphoea	22.48	13.36	10	70398	160	29503959
Infusion site discolouration	22.41	13.36	9	70399	110	29504009
Glioblastoma multiforme	22.34	13.36	16	70392	661	29503458
Enterovirus infection	22.34	13.36	16	70392	661	29503458
Haematopoietic stem cell mobilisation	22.31	13.36	10	70398	163	29503956
Pneumocystis jirovecii infection	22.23	13.36	22	70386	1426	29502693
Cutaneous T-cell lymphoma recurrent	22.21	13.36	7	70401	39	29504080
Gait inability	22.16	13.36	8	70400	18367	29485752
Transient ischaemic attack	22.15	13.36	14	70394	23256	29480863
Adverse drug reaction	22.12	13.36	15	70393	24005	29480114
COVID-19 pneumonia	22.06	13.36	61	70347	9461	29494658
Stevens-Johnson syndrome	22.01	13.36	6	70402	16491	29487628
Periorbital infection	21.98	13.36	9	70399	116	29504003
Treatment failure	21.97	13.36	157	70251	36782	29467337
Acute lung injury	21.86	13.36	21	70387	1312	29502807
Faeces discoloured	21.71	13.36	3	70405	13348	29490771
Bacterial infection	21.64	13.36	74	70334	12874	29491245
Clostridium difficile colitis	21.64	13.36	75	70333	13137	29490982
Phlebitis infective	21.64	13.36	9	70399	121	29503998
Blood urea increased	21.60	13.36	21	70387	28091	29476028
Intentional product use issue	21.56	13.36	174	70234	42324	29461795
Positron emission tomogram abnormal	21.38	13.36	9	70399	125	29503994
Sphingomonas paucimobilis infection	21.37	13.36	7	70401	45	29504074
Fluid retention	21.32	13.36	15	70393	23545	29480574
Spindle cell sarcoma	21.31	13.36	9	70399	126	29503993
Oesophageal candidiasis	21.26	13.36	35	70373	3786	29500333
Hepatitis viral	21.22	13.36	14	70394	505	29503614
Streptococcal infection	20.90	13.36	38	70370	4450	29499669
Blood pressure systolic increased	20.89	13.36	7	70401	16838	29487281
Burning sensation	20.89	13.36	6	70402	15932	29488187
Dry skin	20.88	13.36	15	70393	23292	29480827
Suspected product quality issue	20.81	13.36	9	70399	134	29503985
Injection site erythema	20.76	13.36	4	70404	13952	29490167
Disorder of orbit	20.75	13.36	8	70400	87	29504032
Salivary gland neoplasm	20.66	13.36	6	70402	24	29504095
Cancer fatigue	20.62	13.36	7	70401	51	29504068
Oxygen saturation decreased	20.54	13.36	48	70360	44889	29459230
Disseminated cytomegaloviral infection	20.50	13.36	10	70398	199	29503920
Taeniasis	20.50	13.36	7	70401	52	29504067
Herpes zoster	20.42	13.36	132	70276	29920	29474199
Scedosporium infection	20.23	13.36	16	70392	769	29503350
Restlessness	20.17	13.36	14	70394	22131	29481988
Clostridium difficile infection	20.14	13.36	84	70324	16057	29488062
Splenic marginal zone lymphoma	20.09	13.36	6	70402	27	29504092
Acute pulmonary histoplasmosis	19.95	13.36	9	70399	149	29503970
Treatment noncompliance	19.92	13.36	17	70391	24210	29479909
Sarcoma metastatic	19.84	13.36	7	70401	58	29504061
Mucoepidermoid carcinoma of salivary gland	19.75	13.36	5	70403	10	29504109
Marginal zone lymphoma recurrent	19.74	13.36	6	70402	29	29504090
Metastases to bone marrow	19.70	13.36	13	70395	469	29503650
Pulmonary embolism	19.65	13.36	273	70135	76261	29427858
Extravasation	19.60	13.36	22	70386	1650	29502469
Electrocardiogram QT prolonged	19.57	13.36	35	70373	36102	29468017
Plasmablastic lymphoma	19.56	13.36	10	70398	221	29503898
Candida endophthalmitis	19.55	13.36	8	70400	103	29504016
Hepatic amoebiasis	19.53	13.36	7	70401	61	29504058
Hepatitis B DNA increased	19.32	13.36	13	70395	485	29503634
Wrong technique in product usage process	19.32	13.36	28	70380	31400	29472719
Adenocarcinoma gastric	19.28	13.36	18	70390	1085	29503034
Swelling	19.27	13.36	34	70374	35249	29468870
Rash pruritic	19.25	13.36	15	70393	22348	29481771
Bone marrow disorder	19.19	13.36	21	70387	1531	29502588
Hepatitis	19.16	13.36	99	70309	20684	29483435
Labelled drug-drug interaction medication error	19.15	13.36	3	70405	12156	29491963
Sleep apnoea syndrome	19.06	13.36	9	70399	17590	29486529
Toxic cardiomyopathy	18.92	13.36	10	70398	237	29503882
Ileus	18.79	13.36	76	70332	14326	29489793
Nausea	18.75	13.36	535	69873	288720	29215399
Gastric stenosis	18.67	13.36	6	70402	36	29504083
Flushing	18.65	13.36	25	70383	28967	29475152
Laboratory test abnormal	18.65	13.36	10	70398	18175	29485944
Hypoaesthesia	18.63	13.36	65	70343	53402	29450717
Splenic candidiasis	18.42	13.36	7	70401	73	29504046
Swelling face	18.35	13.36	13	70395	20337	29483782
Superior vena cava syndrome	18.34	13.36	13	70395	528	29503591
Surgery	18.34	13.36	3	70405	11776	29492343
Systemic mycosis	18.32	13.36	19	70389	1302	29502817
Venous thrombosis	18.20	13.36	29	70379	3053	29501066
Scleroderma	18.12	13.36	19	70389	1319	29502800
Blood lactate dehydrogenase increased	18.06	13.36	92	70316	19117	29485002
Premature ageing	17.85	13.36	7	70401	80	29504039
Abdominal neoplasm	17.80	13.36	9	70399	194	29503925
Diabetic ketoacidosis	17.75	13.36	8	70400	16065	29488054
Immunosuppression	17.70	13.36	39	70369	5247	29498872
Chronic lymphocytic leukaemia refractory	17.70	13.36	7	70401	82	29504037
Chromosome analysis abnormal	17.65	13.36	8	70400	134	29503985
Total lung capacity decreased	17.61	13.36	13	70395	563	29503556
B precursor type acute leukaemia	17.60	13.36	8	70400	135	29503984
B-cell type acute leukaemia	17.58	13.36	10	70398	275	29503844
Nightmare	17.57	13.36	3	70405	11414	29492705
Lip swelling	17.55	13.36	4	70404	12406	29491713
Cryptococcal fungaemia	17.40	13.36	7	70401	86	29504033
Seizure	17.39	13.36	140	70268	92983	29411136
Dysgeusia	17.35	13.36	17	70391	22657	29481462
Amnesia	17.30	13.36	17	70391	22626	29481493
Helicobacter sepsis	17.21	13.36	5	70403	20	29504099
Facial paresis	17.20	13.36	26	70382	2615	29501504
IIIrd nerve paresis	17.18	13.36	7	70401	89	29504030
Acute hepatic failure	17.16	13.36	65	70343	11887	29492232
Plasma cell myeloma refractory	17.11	13.36	7	70401	90	29504029
Injection site reaction	17.09	13.36	3	70405	11185	29492934
Pneumonia salmonella	17.08	13.36	6	70402	49	29504070
Hot flush	17.06	13.36	7	70401	14863	29489256
Rhabdomyosarcoma recurrent	17.04	13.36	7	70401	91	29504028
Fanconi syndrome	17.00	13.36	20	70388	1578	29502541
Focal nodular hyperplasia	16.98	13.36	8	70400	147	29503972
Abdominal wound dehiscence	16.91	13.36	7	70401	93	29504026
Fusarium infection	16.91	13.36	16	70392	981	29503138
Postural tremor	16.86	13.36	10	70398	298	29503821
Granulocytopenia neonatal	16.83	13.36	5	70403	22	29504097
Visual impairment	16.79	13.36	28	70380	29680	29474439
Cholelithiasis	16.75	13.36	12	70396	18660	29485459
Eczema	16.71	13.36	6	70402	13820	29490299
Small intestinal perforation	16.66	13.36	20	70388	1612	29502507
Lactic acidosis	16.65	13.36	29	70379	30218	29473901
Ichthyosis	16.64	13.36	7	70401	97	29504022
Liver function test abnormal	16.59	13.36	27	70381	28891	29475228
Guillain-Barre syndrome	16.58	13.36	37	70371	5021	29499098
Disturbance in attention	16.46	13.36	16	70392	21408	29482711
Wound evisceration	16.45	13.36	7	70401	100	29504019
Disseminated cryptococcosis	16.44	13.36	17	70391	1161	29502958
Resorption bone increased	16.41	13.36	8	70400	159	29503960
Drug ineffective for unapproved indication	16.21	13.36	72	70336	14142	29489977
Skin exfoliation	16.18	13.36	18	70390	22627	29481492
Respiratory depression	16.12	13.36	6	70402	13517	29490602
Benign prostatic hyperplasia	16.12	13.36	4	70404	11706	29492413
Renal disorder	16.10	13.36	18	70390	22577	29481542
Vertigo	16.03	13.36	17	70391	21844	29482275
Mastitis	16.01	13.36	8	70400	168	29503951
Combined immunodeficiency	16.01	13.36	6	70402	60	29504059
Dementia	16.01	13.36	4	70404	11654	29492465
Metastasis	15.93	13.36	29	70379	3400	29500719
Plasma cell leukaemia	15.88	13.36	14	70394	783	29503336
Therapy responder	15.84	13.36	8	70400	172	29503947
Blindness cortical	15.82	13.36	10	70398	335	29503784
Hallucination, visual	15.78	13.36	8	70400	15007	29489112
Musculoskeletal pain	15.72	13.36	28	70380	28925	29475194
Hepatotoxicity	15.71	13.36	84	70324	17783	29486336
Adrenocortical carcinoma	15.70	13.36	5	70403	29	29504090
Congenital hepatobiliary anomaly	15.70	13.36	5	70403	29	29504090
Depressed level of consciousness	15.67	13.36	41	70367	36901	29467218
Blastic plasmacytoid dendritic cell neoplasia	15.67	13.36	6	70402	64	29504055
Hip fracture	15.62	13.36	3	70405	10489	29493630
Myeloid leukaemia	15.58	13.36	10	70398	344	29503775
Leukonychia	15.48	13.36	4	70404	9	29504110
Bone marrow infiltration	15.46	13.36	7	70401	117	29504002
Neoplasm	15.43	13.36	32	70376	4129	29499990
Lymphocytosis	15.42	13.36	21	70387	1919	29502200
Neuroborreliosis	15.42	13.36	5	70403	31	29504088
Mental status changes	15.41	13.36	38	70370	34889	29469230
Dyskinesia	15.40	13.36	15	70393	20046	29484073
Enterococcal infection	15.38	13.36	49	70359	8219	29495900
Erythema	15.37	13.36	111	70297	75495	29428624
Pneumonia mycoplasmal	15.35	13.36	12	70396	567	29503552
Candida sepsis	15.30	13.36	16	70392	1107	29503012
Heart disease congenital	15.27	13.36	17	70391	1263	29502856
Influenza	15.21	13.36	50	70358	41831	29462288
Leukoencephalopathy	15.20	13.36	30	70378	3737	29500382
Diabetes mellitus inadequate control	15.12	13.36	5	70403	12129	29491990
Delusion	15.11	13.36	4	70404	11212	29492907
Pseudomonal sepsis	15.11	13.36	26	70382	2916	29501203
Lewis-Sumner syndrome	15.02	13.36	5	70403	34	29504085
Paternal exposure timing unspecified	15.02	13.36	5	70403	34	29504085
Dehydration	14.98	13.36	188	70220	114560	29389559
Hepatitis C RNA increased	14.97	13.36	9	70399	275	29503844
Leukaemia	14.96	13.36	30	70378	3780	29500339
Neuroblastoma recurrent	14.89	13.36	6	70402	74	29504045
Influenza like illness	14.84	13.36	22	70386	24448	29479671
Coronary artery occlusion	14.79	13.36	3	70405	10091	29494028
Pneumaturia	14.78	13.36	5	70403	36	29504083
Genotoxicity	14.78	13.36	5	70403	36	29504083
Humoral immune defect	14.75	13.36	6	70402	76	29504043
Chemotherapeutic drug level increased	14.68	13.36	8	70400	202	29503917
Spinal cord ischaemia	14.68	13.36	6	70402	77	29504042
Therapeutic product effect decreased	14.66	13.36	30	70378	29421	29474698
Metapneumovirus bronchiolitis	14.65	13.36	4	70404	12	29504107
Peripheral T-cell lymphoma unspecified refractory	14.65	13.36	4	70404	12	29504107
Granulocyte count decreased	14.56	13.36	12	70396	612	29503507
Acute hepatitis B	14.55	13.36	7	70401	135	29503984
Asthenia	14.46	13.36	396	70012	214854	29289265
Plasma cell myeloma recurrent	14.46	13.36	29	70379	3654	29500465
Metastases to meninges	14.37	13.36	16	70392	1189	29502930
Metabolic acidosis	14.36	13.36	44	70364	37618	29466501
Extrapyramidal disorder	14.34	13.36	4	70404	10827	29493292
Neck pain	14.30	13.36	18	70390	21429	29482690
Hepatosplenomegaly	14.28	13.36	29	70379	3688	29500431
Hypersomnia	14.18	13.36	4	70404	10750	29493369
Oligohydramnios	14.17	13.36	9	70399	304	29503815
Cytomegalovirus viraemia	14.16	13.36	40	70368	6280	29497839
Neutrophil count increased	14.13	13.36	71	70337	14671	29489448
Sudden death	14.12	13.36	8	70400	14102	29490017
Cryptosporidiosis infection	14.09	13.36	10	70398	407	29503712
Visual acuity reduced	14.09	13.36	9	70399	14867	29489252
Hypercalcaemia	14.08	13.36	64	70344	12695	29491424
Sinusitis bacterial	14.06	13.36	9	70399	308	29503811
Exophthalmos	14.05	13.36	11	70397	521	29503598
Optic ischaemic neuropathy	14.05	13.36	20	70388	1906	29502213
Respiratory tract infection	14.04	13.36	74	70334	15577	29488542
Stomatitis necrotising	14.02	13.36	6	70402	87	29504032
VIth nerve paresis	14.01	13.36	5	70403	43	29504076
Abdominal mass	14.00	13.36	16	70392	1224	29502895
Embolism	13.87	13.36	42	70366	6854	29497265
Central nervous system enteroviral infection	13.81	13.36	5	70403	45	29504074
Blindness	13.79	13.36	61	70347	11962	29492157
Coxsackie viral infection	13.77	13.36	4	70404	16	29504103
Torulopsis infection	13.77	13.36	4	70404	16	29504103
Coma	13.72	13.36	48	70360	39402	29464717
Swollen tongue	13.71	13.36	6	70402	12260	29491859
Haemoptysis	13.66	13.36	33	70375	30517	29473602
Gingivitis ulcerative	13.62	13.36	5	70403	47	29504072
Stem cell transplant	13.57	13.36	20	70388	1967	29502152
Pneumonia respiratory syncytial viral	13.55	13.36	13	70395	811	29503308
Systemic candida	13.54	13.36	24	70384	2756	29501363
Chronic myelomonocytic leukaemia	13.53	13.36	11	70397	550	29503569
Procedural pneumothorax	13.52	13.36	5	70403	48	29504071
Human polyomavirus infection	13.49	13.36	12	70396	679	29503440
Hip deformity	13.49	13.36	6	70402	96	29504023
Cutaneous T-cell lymphoma	13.45	13.36	16	70392	1277	29502842
Febrile infection	13.44	13.36	20	70388	1984	29502135
Tuberculosis liver	13.43	13.36	5	70403	49	29504070
Subclavian vein thrombosis	13.40	13.36	13	70395	822	29503297

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	7040.98	12.06	4594	134312	183063	64176763
Neutropenia	2884.95	12.06	3037	135869	236587	64123239
Acute myeloid leukaemia	1378.86	12.06	813	138093	26650	64333176
Product use in unapproved indication	1366.85	12.06	1788	137118	174830	64184996
Myelodysplastic syndrome	1205.40	12.06	747	138159	26832	64332994
Mucosal inflammation	1202.34	12.06	1030	137876	61554	64298272
Second primary malignancy	1192.92	12.06	566	138340	11771	64348055
Haematotoxicity	1166.02	12.06	565	138341	12331	64347495
Off label use	1032.94	12.06	3342	135564	629464	63730362
Cardiotoxicity	1007.55	12.06	476	138430	9798	64350028
Bone marrow failure	914.22	12.06	786	138120	47166	64312660
Disease progression	903.14	12.06	1307	137599	140373	64219453
Thrombocytopenia	857.56	12.06	1642	137264	222159	64137667
Pancytopenia	808.86	12.06	1249	137657	142060	64217766
Diffuse large B-cell lymphoma recurrent	802.72	12.06	289	138617	2857	64356969
Hepatitis B	702.07	12.06	340	138566	7405	64352421
Malignant neoplasm progression	670.90	12.06	1008	137898	111863	64247963
Pneumocystis jirovecii pneumonia	605.32	12.06	491	138415	27143	64332683
Febrile bone marrow aplasia	598.44	12.06	346	138560	10909	64348917
Hepatitis B reactivation	594.10	12.06	263	138643	4626	64355200
Myelosuppression	585.44	12.06	453	138453	23377	64336449
Tumour lysis syndrome	567.84	12.06	410	138496	19030	64340796
Cardiomyopathy	560.60	12.06	453	138453	24903	64334923
Interstitial lung disease	519.29	12.06	829	138077	96903	64262923
Neutropenic sepsis	471.02	12.06	395	138511	22877	64336949
Ejection fraction decreased	443.16	12.06	418	138488	28289	64331537
Fall	438.44	12.06	175	138731	416651	63943175
Neoplasm progression	416.79	12.06	477	138429	40487	64319339
Leukopenia	413.10	12.06	764	138142	100478	64259348
Septic shock	409.48	12.06	779	138127	104658	64255168
Joint swelling	375.49	12.06	22	138884	215360	64144466
Pyrexia	373.92	12.06	2263	136643	556381	63803445
Neuropathy peripheral	373.68	12.06	799	138107	116726	64243100
Neutrophil count decreased	368.34	12.06	624	138282	76572	64283254
Sepsis	341.17	12.06	1181	137725	229160	64130666
Pain	336.08	12.06	420	138486	553091	63806735
Therapy partial responder	336.01	12.06	232	138674	10016	64349810
Rheumatoid arthritis	323.80	12.06	6	138900	164288	64195538
Posterior reversible encephalopathy syndrome	318.14	12.06	315	138591	22631	64337195
Anaemia	318.10	12.06	1632	137274	377048	63982778
Arthralgia	315.62	12.06	293	138613	441967	63917859
Palmar-plantar erythrodysaesthesia syndrome	304.01	12.06	342	138564	28477	64331349
Cytopenia	297.46	12.06	255	138651	15216	64344610
Product dose omission issue	288.30	12.06	39	138867	194708	64165118
Peripheral swelling	278.25	12.06	56	138850	209097	64150729
Acquired gene mutation	267.86	12.06	115	138791	1871	64357955
Headache	264.36	12.06	460	138446	529007	63830819
Left ventricular dysfunction	263.79	12.06	248	138658	16706	64343120
Progressive multifocal leukoencephalopathy	255.92	12.06	252	138654	17980	64341846
Diffuse large B-cell lymphoma refractory	252.42	12.06	94	138812	1030	64358796
Dizziness	248.87	12.06	338	138568	429825	63930001
Metastases to bone	246.01	12.06	260	138646	20175	64339651
Drug hypersensitivity	244.57	12.06	103	138803	237712	64122114
Weight increased	241.90	12.06	79	138827	213269	64146557
Pruritus	227.35	12.06	203	138703	312197	64047629
Drug abuse	226.18	12.06	15	138891	132359	64227467
Disease recurrence	218.43	12.06	303	138603	31207	64328619
Cardiac failure	218.13	12.06	704	138202	131669	64228157
Abdominal discomfort	216.61	12.06	62	138844	182260	64177566
Congestive cardiomyopathy	210.14	12.06	176	138730	10168	64349658
Cytomegalovirus chorioretinitis	209.28	12.06	131	138775	4781	64355045
Rash	204.51	12.06	426	138480	458123	63901703
Nasopharyngitis	201.42	12.06	85	138821	195988	64163838
B-cell lymphoma recurrent	199.44	12.06	73	138833	759	64359067
Metastases to lung	192.30	12.06	199	138707	15065	64344761
Musculoskeletal stiffness	191.29	12.06	21	138885	123185	64236641
Synovitis	189.79	12.06	5	138901	99085	64260741
Insomnia	188.89	12.06	95	138811	197741	64162085
White blood cell count decreased	187.24	12.06	754	138152	157083	64202743
Polyneuropathy	181.26	12.06	219	138687	19675	64340151
Anxiety	180.81	12.06	106	138800	202543	64157283
Multiple organ dysfunction syndrome	179.55	12.06	553	138353	100860	64258966
Somnolence	175.45	12.06	111	138795	203534	64156292
Lymphadenopathy	174.99	12.06	340	138566	46346	64313480
Intentional overdose	174.32	12.06	4	138902	89940	64269886
Arthropathy	172.51	12.06	27	138879	120940	64238886
Blood pressure increased	170.60	12.06	79	138827	172473	64187353
Acute promyelocytic leukaemia	169.69	12.06	75	138831	1313	64358513
Overdose	165.75	12.06	68	138838	159498	64200328
Muscle spasms	163.74	12.06	50	138856	140973	64218853
Pain in extremity	163.39	12.06	250	138656	302835	64056991
Haemophagocytic lymphohistiocytosis	162.31	12.06	195	138711	17414	64342412
Swelling	162.07	12.06	71	138835	160147	64199679
Neutropenic colitis	160.35	12.06	108	138798	4473	64355353
Aplasia	157.39	12.06	126	138780	6827	64352999
Injection site pain	156.32	12.06	26	138880	111382	64248444
Feeling abnormal	155.78	12.06	47	138859	133555	64226271
Metastases to liver	153.77	12.06	222	138684	23719	64336107
Pneumonitis	151.43	12.06	335	138571	50030	64309796
Platelet count decreased	148.18	12.06	734	138172	166977	64192849
Contusion	146.39	12.06	33	138873	113932	64245894
Peripheral sensory neuropathy	144.52	12.06	149	138757	11229	64348597
Mantle cell lymphoma recurrent	143.98	12.06	50	138856	440	64359386
Neurotoxicity	143.34	12.06	231	138675	27173	64332653
Drug resistance	141.87	12.06	264	138642	34838	64324988
Pleural effusion	141.67	12.06	594	138312	125965	64233861
Intentional product misuse	140.93	12.06	3	138903	72292	64287534
Malaise	137.01	12.06	419	138487	395828	63963998
Anti-Muellerian hormone level decreased	137.00	12.06	34	138872	70	64359756
Drug interaction	133.06	12.06	372	138534	361711	63998115
Urticaria	132.87	12.06	76	138830	147241	64212585
Myocardial infarction	131.35	12.06	99	138807	165722	64194104
Epstein-Barr virus infection	129.63	12.06	147	138759	12341	64347485
Hepatic failure	127.27	12.06	332	138574	55062	64304764
Stomatitis	127.03	12.06	520	138386	109085	64250741
Confusional state	125.37	12.06	232	138674	260912	64098914
Rhabdomyolysis	125.19	12.06	23	138883	91703	64268123
Gene mutation	124.12	12.06	69	138837	2013	64357813
Psoriasis	119.92	12.06	9	138897	71694	64288132
Fatigue	119.80	12.06	1035	137871	747695	63612131
Depression	119.49	12.06	131	138775	183160	64176666
Post transplant lymphoproliferative disorder	119.45	12.06	124	138782	9420	64350406
Lymphopenia	119.10	12.06	205	138701	25452	64334374
Therapeutic product effect decreased	116.82	12.06	51	138855	115300	64244526
Pemphigus	116.46	12.06	3	138903	60698	64299128
Venoocclusive disease	116.22	12.06	84	138822	3901	64355925
Diffuse large B-cell lymphoma	114.47	12.06	126	138780	10235	64349591
Contraindicated product administered	113.50	12.06	45	138861	107784	64252042
Venoocclusive liver disease	112.74	12.06	123	138783	9892	64349934
Bronchopulmonary aspergillosis	109.69	12.06	168	138738	18917	64340909
Neoplasm recurrence	109.47	12.06	79	138827	3660	64356166
Wound	109.18	12.06	17	138889	76460	64283366
Cytomegalovirus infection	109.08	12.06	245	138661	36954	64322872
Metastases to lymph nodes	108.64	12.06	113	138793	8604	64351222
Asthma	108.30	12.06	35	138871	95190	64264636
Discomfort	104.70	12.06	23	138883	80855	64278971
Hospitalisation	104.50	12.06	18	138888	75189	64284637
Cerebrovascular accident	104.08	12.06	86	138820	137497	64222329
Bone pain	104.08	12.06	280	138626	47292	64312534
Hypogammaglobulinaemia	101.45	12.06	118	138788	10181	64349645
Myelopathy	100.74	12.06	77	138829	3897	64355929
Cystitis haemorrhagic	100.71	12.06	104	138802	7852	64351974
Stress	100.09	12.06	8	138898	60526	64299300
Salivary gland cancer	99.33	12.06	36	138870	363	64359463
Sinusitis	98.79	12.06	101	138805	145827	64213999
Arthritis	98.56	12.06	29	138877	83785	64276041
Acute lymphocytic leukaemia	98.49	12.06	79	138827	4292	64355534
Bacteraemia	98.41	12.06	194	138712	26717	64333109
Intestinal perforation	98.34	12.06	142	138764	15171	64344655
Bradycardia	98.28	12.06	67	138839	118152	64241674
Staphylococcal bacteraemia	97.61	12.06	116	138790	10239	64349587
Hypoglycaemia	97.12	12.06	36	138870	89856	64269970
Injection site erythema	96.08	12.06	18	138888	70782	64289044
Glossodynia	95.55	12.06	13	138893	64683	64295143
Respiratory failure	94.11	12.06	632	138274	160551	64199275
Acute lymphocytic leukaemia recurrent	93.35	12.06	74	138832	3952	64355874
Tremor	93.26	12.06	109	138797	148121	64211705
Wheezing	92.73	12.06	29	138877	80550	64279276
Suicide attempt	92.30	12.06	20	138886	70987	64288839
Abdominal pain upper	91.71	12.06	147	138759	174883	64184943
Bronchitis	91.24	12.06	61	138845	108682	64251144
Herpes simplex	91.13	12.06	113	138793	10423	64349403
Ascites	90.73	12.06	317	138589	61684	64298142
Blood glucose increased	90.72	12.06	49	138857	98024	64261802
Traumatic lung injury	90.22	12.06	58	138848	2218	64357608
Hepatic enzyme increased	89.02	12.06	89	138817	129854	64229972
Aspergillus infection	88.30	12.06	140	138766	16239	64343587
Candida infection	87.76	12.06	203	138703	31216	64328610
Pulmonary toxicity	87.54	12.06	100	138806	8461	64351365
Heart rate decreased	86.43	12.06	9	138897	55058	64304768
Gait disturbance	85.20	12.06	150	138756	172005	64187821
Osteoarthritis	84.05	12.06	17	138889	63319	64296507
Sweat gland tumour	83.87	12.06	34	138872	475	64359351
Agranulocytosis	83.61	12.06	225	138681	38004	64321822
Skin toxicity	83.02	12.06	86	138820	6516	64353310
Inappropriate schedule of product administration	82.63	12.06	48	138858	92238	64267588
Loss of personal independence in daily activities	81.73	12.06	27	138879	72427	64287399
Myeloid leukaemia	81.32	12.06	35	138871	573	64359253
Injury	80.94	12.06	12	138894	55980	64303846
JC virus infection	80.67	12.06	63	138843	3292	64356534
Nephropathy toxic	80.06	12.06	139	138767	17375	64342451
Osteonecrosis	79.51	12.06	183	138723	28046	64331780
Refractory anaemia with an excess of blasts	79.26	12.06	38	138868	808	64359018
Balance disorder	78.99	12.06	41	138865	83885	64275941
Metastasis	78.58	12.06	78	138828	5617	64354209
Smooth muscle cell neoplasm	78.41	12.06	38	138868	828	64358998
Suicidal ideation	78.28	12.06	23	138883	66519	64293307
5q minus syndrome	75.60	12.06	27	138879	260	64359566
Metastases to peritoneum	75.47	12.06	62	138844	3485	64356341
Leukaemia	74.52	12.06	72	138834	5016	64354810
Blood cholesterol increased	74.08	12.06	10	138896	50056	64309770
Malignant transformation	74.06	12.06	40	138866	1101	64358725
Injection site swelling	72.67	12.06	4	138902	41349	64318477
Cytokine release syndrome	72.38	12.06	147	138759	20682	64339144
Mobility decreased	72.21	12.06	48	138858	85792	64274034
Small intestinal obstruction	72.19	12.06	158	138748	23415	64336411
Bone marrow disorder	72.19	12.06	55	138851	2770	64357056
Systemic candida	71.71	12.06	72	138834	5257	64354569
Cardio-respiratory arrest	71.36	12.06	64	138842	98329	64261497
Anaplastic lymphoma kinase gene mutation	70.93	12.06	21	138885	103	64359723
Coronary artery disease	70.89	12.06	21	138885	60412	64299414
Klebsiella infection	70.88	12.06	113	138793	13168	64346658
Plasmacytoma	70.76	12.06	62	138844	3808	64356018
Remission not achieved	69.93	12.06	27	138879	329	64359497
Lung infiltration	69.73	12.06	145	138761	20744	64339082
Heart rate increased	69.41	12.06	66	138840	98609	64261217
Drug intolerance	69.04	12.06	193	138713	187799	64172027
Aggression	68.96	12.06	9	138897	46223	64313603
Injection site pruritus	68.58	12.06	3	138903	37823	64322003
Cytogenetic abnormality	68.55	12.06	37	138869	1017	64358809
Cardiomyopathy acute	68.44	12.06	24	138882	218	64359608
Colitis	68.43	12.06	279	138627	58395	64301431
Chest pain	68.28	12.06	269	138637	235711	64124115
Viral haemorrhagic cystitis	68.13	12.06	43	138863	1592	64358234
Psoriatic arthropathy	68.12	12.06	7	138899	43274	64316552
Chronic myeloid leukaemia	67.68	12.06	57	138849	3317	64356509
Myalgia	67.46	12.06	151	138755	158466	64201360
Respiratory arrest	66.71	12.06	16	138890	52969	64306857
Blood pressure fluctuation	66.63	12.06	15	138891	51856	64307970
Nephrolithiasis	66.39	12.06	8	138898	43675	64316151
Gastrointestinal toxicity	66.34	12.06	69	138837	5253	64354573
Metastases to central nervous system	65.67	12.06	112	138794	13800	64346026
Administration site extravasation	65.61	12.06	36	138870	1023	64358803
Injection site bruising	65.57	12.06	3	138903	36370	64323456
Injection site reaction	65.19	12.06	11	138895	46653	64313173
Peripheral T-cell lymphoma unspecified	64.84	12.06	30	138876	587	64359239
Irritable bowel syndrome	64.49	12.06	4	138902	37365	64322461
Metastases to breast	64.35	12.06	23	138883	222	64359604
Fibromyalgia	64.24	12.06	3	138903	35728	64324098
Central nervous system lymphoma	63.88	12.06	44	138862	1891	64357935
Musculoskeletal pain	63.74	12.06	49	138857	81245	64278581
Chronic obstructive pulmonary disease	63.53	12.06	37	138869	71011	64288815
Encephalopathy	62.61	12.06	272	138634	58547	64301279
Acute hepatitis B	61.87	12.06	26	138880	400	64359426
Drug reaction with eosinophilia and systemic symptoms	61.51	12.06	20	138886	54197	64305629
End stage renal disease	61.31	12.06	93	138813	10382	64349444
Incorrect dose administered	61.29	12.06	27	138879	60738	64299088
Breast cancer recurrent	61.01	12.06	48	138858	2535	64357291
Hallucination	60.82	12.06	41	138865	72747	64287079
Memory impairment	60.63	12.06	57	138849	85625	64274201
Neutrophil count abnormal	60.32	12.06	50	138856	2846	64356980
Loss of consciousness	60.07	12.06	145	138761	148220	64211606
Pneumonia	59.74	12.06	1602	137304	557974	63801852
Infection reactivation	59.68	12.06	43	138863	1987	64357839
Hyperhidrosis	58.97	12.06	112	138794	124808	64235018
Hypersensitivity	58.71	12.06	221	138685	196231	64163595
Lymphoma transformation	58.64	12.06	21	138885	204	64359622
Mucosal toxicity	58.27	12.06	26	138880	466	64359360
Recurrent cancer	58.01	12.06	45	138861	2328	64357498
International normalised ratio increased	58.00	12.06	51	138855	79116	64280710
Breast cancer metastatic	57.42	12.06	74	138832	7095	64352731
Peripheral motor neuropathy	57.17	12.06	49	138857	2921	64356905
Angioedema	57.00	12.06	31	138875	61790	64298036
Agitation	56.62	12.06	64	138842	88303	64271523
Fluid retention	56.26	12.06	29	138877	59577	64300249
Death	56.22	12.06	718	138188	481987	63877839
Blood creatine phosphokinase increased	56.01	12.06	28	138878	58530	64301296
Premature menopause	55.77	12.06	26	138880	518	64359308
Plasma cell leukaemia	55.28	12.06	37	138869	1516	64358310
Pneumonia fungal	55.08	12.06	81	138825	8796	64351030
Condition aggravated	54.43	12.06	526	138380	371900	63987926
Extravasation	54.28	12.06	49	138857	3131	64356695
Computerised tomogram thorax abnormal	54.01	12.06	40	138866	1929	64357897
BK virus infection	53.95	12.06	73	138833	7339	64352487
Enterococcal bacteraemia	53.75	12.06	44	138862	2461	64357365
Nasal congestion	53.44	12.06	31	138875	59627	64300199
Serotonin syndrome	53.27	12.06	10	138896	39272	64320554
Varicella zoster virus infection	53.18	12.06	53	138853	3835	64355991
Blood pressure systolic increased	53.08	12.06	20	138886	49433	64310393
Post embolisation syndrome	52.93	12.06	15	138891	61	64359765
Metastases to skin	52.67	12.06	35	138871	1417	64358409
Gastrooesophageal reflux disease	52.42	12.06	61	138845	83082	64276744
Neck pain	52.30	12.06	34	138872	61499	64298327
Chloroma	52.23	12.06	27	138879	678	64359148
Pneumocystis jirovecii infection	51.77	12.06	42	138864	2319	64357507
Pneumatosis intestinalis	51.65	12.06	60	138846	5169	64354657
Diarrhoea	50.79	12.06	1178	137728	721526	63638300
Thrombotic microangiopathy	50.28	12.06	111	138795	16544	64343282
Escherichia bacteraemia	50.06	12.06	60	138846	5343	64354483
Palpitations	49.91	12.06	93	138813	104395	64255431
Ileus paralytic	49.66	12.06	75	138831	8340	64351486
Ovarian failure	49.61	12.06	24	138882	521	64359305
Device related infection	49.56	12.06	162	138744	30464	64329362
Drug withdrawal syndrome	49.40	12.06	5	138901	31286	64328540
Abnormal behaviour	49.07	12.06	7	138899	33615	64326211
Toxic cardiomyopathy	48.83	12.06	21	138885	343	64359483
Unevaluable event	48.50	12.06	24	138882	50465	64309361
Pericardial effusion	48.44	12.06	190	138716	39064	64320762
Rash pruritic	48.41	12.06	32	138874	57372	64302454
Dyspnoea	48.12	12.06	1180	137726	717494	63642332
Drug clearance decreased	47.97	12.06	42	138864	2577	64357249
Joint stiffness	47.63	12.06	5	138901	30399	64329427
Toxic erythema of chemotherapy	47.02	12.06	18	138888	214	64359612
Philadelphia chromosome positive	46.78	12.06	24	138882	593	64359233
Gastrosplenic fistula	46.27	12.06	14	138892	75	64359751
Pneumonia klebsiella	46.17	12.06	50	138856	3987	64355839
Road traffic accident	45.82	12.06	6	138900	30739	64329087
Hyperkalaemia	45.71	12.06	93	138813	101036	64258790
Escherichia infection	45.69	12.06	101	138805	15067	64344759
Ventricular hypokinesia	45.50	12.06	69	138837	7700	64352126
Oedema peripheral	45.49	12.06	266	138640	210051	64149775
Pseudomonas infection	45.03	12.06	111	138795	17772	64342054
Enterococcal infection	44.82	12.06	95	138811	13771	64346055
Impaired healing	44.24	12.06	39	138867	60434	64299392
Ileus	44.15	12.06	129	138777	22837	64336989
Blood stem cell transplant failure	44.04	12.06	22	138884	513	64359313
Product prescribing error	43.72	12.06	11	138895	35258	64324568
Sopor	43.70	12.06	6	138900	29655	64330171
Lower respiratory tract infection	43.63	12.06	86	138820	94528	64265298
Product use issue	43.49	12.06	509	138397	151206	64208620
Vision blurred	43.48	12.06	80	138826	90236	64269590
Blister	43.33	12.06	67	138839	80900	64278926
Surgery	43.28	12.06	5	138901	28208	64331618
Toxicity to various agents	43.28	12.06	538	138368	362975	63996851
Blood lactate dehydrogenase increased	43.19	12.06	163	138743	32915	64326911
Acute myelomonocytic leukaemia	43.13	12.06	18	138888	272	64359554
Adverse drug reaction	43.09	12.06	22	138884	45442	64314384
Myelitis	43.00	12.06	36	138870	2078	64357748
Cataract	42.66	12.06	29	138877	51233	64308593
Epstein-Barr virus associated lymphoma	42.58	12.06	26	138880	907	64358919
Accidental overdose	42.51	12.06	10	138896	33547	64326279
Hepatotoxicity	41.91	12.06	184	138722	39778	64320048
White blood cell count abnormal	41.88	12.06	52	138854	4802	64355024
Colony stimulating factor therapy	41.87	12.06	21	138885	494	64359332
Heart rate irregular	41.70	12.06	5	138901	27408	64332418
Infection	41.51	12.06	593	138313	184287	64175539
Treatment noncompliance	41.27	12.06	21	138885	43461	64316365
Swollen tongue	41.26	12.06	12	138894	34942	64324884
Blood pressure decreased	40.92	12.06	77	138829	86122	64273704
Intertrigo	40.91	12.06	22	138884	600	64359226
Flagellate dermatitis	40.79	12.06	16	138890	204	64359622
Perineal necrosis	40.74	12.06	14	138892	119	64359707
Alveolar soft part sarcoma	40.52	12.06	13	138893	87	64359739
Atelectasis	40.38	12.06	140	138766	27126	64332700
Liver function test abnormal	40.30	12.06	41	138865	59360	64300466
C-reactive protein abnormal	40.24	12.06	7	138899	29040	64330786
Clonal evolution	40.23	12.06	16	138890	212	64359614
Staphylococcal sepsis	40.11	12.06	87	138819	12812	64347014
Lymphadenitis	40.04	12.06	45	138861	3740	64356086
Swelling face	39.96	12.06	41	138865	59125	64300701
Lymphoma	39.95	12.06	91	138815	13850	64345976
Refractory cancer	39.70	12.06	16	138890	220	64359606
Emotional distress	39.65	12.06	14	138892	36024	64323802
Amnesia	39.25	12.06	28	138878	48241	64311585
Gastric perforation	39.19	12.06	43	138863	3480	64356346
Withdrawal syndrome	39.13	12.06	3	138903	23489	64336337
Hypoxia	39.10	12.06	324	138582	87825	64272001
Clostridium difficile infection	39.07	12.06	168	138738	35995	64323831
Visual impairment	38.97	12.06	62	138844	74015	64285811
Osteosarcoma metastatic	38.77	12.06	11	138895	45	64359781
Peripheral sensorimotor neuropathy	38.65	12.06	37	138869	2548	64357278
Hepatitis E	38.65	12.06	36	138870	2395	64357431
Endocarditis noninfective	38.54	12.06	15	138891	187	64359639
B-cell lymphoma refractory	38.52	12.06	13	138893	104	64359722
Cutaneous calcification	38.41	12.06	13	138893	105	64359721
Cytomegalovirus viraemia	38.31	12.06	77	138829	10751	64349075
Escherichia sepsis	38.28	12.06	61	138845	7104	64352722
Gastritis bacterial	38.24	12.06	17	138889	302	64359524
Subdural hygroma	38.19	12.06	19	138887	439	64359387
Osteosarcoma recurrent	38.14	12.06	10	138896	28	64359798
Ganglioneuroblastoma	38.14	12.06	10	138896	28	64359798
Gastrointestinal fungal infection	38.10	12.06	18	138888	370	64359456
Gastric stenosis	38.09	12.06	13	138893	108	64359718
West Nile viral infection	37.92	12.06	24	138882	893	64358933
Cytomegalovirus infection reactivation	37.87	12.06	54	138852	5702	64354124
Chemotherapy	37.76	12.06	29	138877	1478	64358348
Electrocardiogram QT prolonged	37.69	12.06	71	138835	79377	64280449
Haematopoietic stem cell mobilisation	37.57	12.06	15	138891	201	64359625
Head injury	37.45	12.06	12	138894	32830	64326996
Sleep disorder	37.43	12.06	44	138862	59665	64300161
Nervousness	37.06	12.06	9	138897	29547	64330279
Ototoxicity	37.02	12.06	37	138869	2686	64357140
Therapy cessation	36.82	12.06	12	138894	32477	64327349
Autoimmune neutropenia	36.82	12.06	18	138888	400	64359426
Transient ischaemic attack	36.75	12.06	25	138881	44157	64315669
Lactic acidosis	36.66	12.06	47	138859	61363	64298463
Restlessness	36.60	12.06	20	138886	39765	64320061
Gait inability	36.57	12.06	23	138883	42345	64317481
Cerebral venous sinus thrombosis	36.52	12.06	31	138875	1824	64358002
Primary cardiac lymphoma	36.44	12.06	9	138897	18	64359808
Metastases to spine	36.31	12.06	42	138864	3601	64356225
Capillary leak syndrome	36.25	12.06	40	138866	3257	64356569
Clostridium difficile colitis	36.25	12.06	135	138771	27088	64332738
Renal tubular disorder	36.24	12.06	54	138852	5933	64353893
Irritability	36.01	12.06	17	138889	36729	64323097
Nail pigmentation	35.90	12.06	16	138890	286	64359540
Weight decreased	35.85	12.06	418	138488	285321	64074505
Mucormycosis	35.84	12.06	60	138846	7281	64352545
Lip swelling	35.79	12.06	12	138894	31895	64327931
Metastases to retroperitoneum	35.69	12.06	17	138889	356	64359470
Hydrothorax	35.53	12.06	26	138880	1231	64358595
Glioma	35.24	12.06	19	138887	521	64359305
Alopecia	35.05	12.06	211	138695	165479	64194347
Depressed level of consciousness	35.03	12.06	77	138829	81359	64278467
Strongyloidiasis	34.86	12.06	38	138868	3052	64356774
Pseudomonal sepsis	34.73	12.06	49	138857	5123	64354703
Blast cells present	34.63	12.06	22	138884	824	64359002
Depressed mood	34.39	12.06	23	138883	40989	64318837
Necrotising gastritis	34.37	12.06	11	138895	73	64359753
Helicobacter infection	34.26	12.06	20	138886	38342	64321484
Amniotic fluid index decreased	34.25	12.06	8	138898	11	64359815
Alveolitis	34.21	12.06	41	138865	3651	64356175
Invasive ductal breast carcinoma	34.20	12.06	48	138858	4994	64354832
Hypertriglyceridaemia	34.19	12.06	75	138831	11130	64348696
Fanconi syndrome	34.04	12.06	34	138872	2467	64357359
Faeces discoloured	33.94	12.06	7	138899	25722	64334104
Labelled drug-drug interaction medication error	33.62	12.06	4	138902	22058	64337768
Haemorrhage	33.34	12.06	76	138830	79275	64280551
Clostridium bacteraemia	33.31	12.06	15	138891	275	64359551
COVID-19 pneumonia	32.97	12.06	94	138812	16410	64343416
Therapy non-responder	32.95	12.06	249	138657	65650	64294176
Organising pneumonia	32.76	12.06	65	138841	8990	64350836
B-cell lymphoma	32.72	12.06	49	138857	5408	64354418
Autoimmune lymphoproliferative syndrome	32.71	12.06	13	138893	172	64359654
Plasma cell myeloma recurrent	32.62	12.06	42	138864	4023	64355803
Bursitis	32.48	12.06	4	138902	21481	64338345
Haematoma	32.44	12.06	31	138875	46219	64313607
Pneumothorax spontaneous	32.30	12.06	23	138883	1043	64358783
Hypoaesthesia	32.20	12.06	172	138734	138936	64220890
Urinary tract infection	32.15	12.06	331	138575	231265	64128561
Squamous cell carcinoma of the oral cavity	31.94	12.06	17	138889	454	64359372
Limb injury	31.83	12.06	6	138900	23499	64336327
Product administration error	31.70	12.06	10	138896	27633	64332193
Influenza	31.70	12.06	120	138786	106411	64253415
Secondary immunodeficiency	31.61	12.06	34	138872	2690	64357136
Hepatitis C RNA increased	31.61	12.06	16	138890	384	64359442
Acute lung injury	31.54	12.06	34	138872	2697	64357129
Unintentional medical device removal	31.50	12.06	54	138852	6680	64353146
Large intestinal ulcer perforation	31.16	12.06	10	138896	67	64359759
Nasal abscess	31.10	12.06	12	138894	146	64359680
Dementia	31.07	12.06	4	138902	20762	64339064
Paraparesis	31.00	12.06	38	138868	3464	64356362
Back pain	30.98	12.06	367	138539	249804	64110022
Lethargy	30.93	12.06	69	138837	72525	64287301
Bone marrow infiltration	30.92	12.06	17	138889	485	64359341
Rhinorrhoea	30.79	12.06	51	138855	59918	64299908
Central nervous system enteroviral infection	30.78	12.06	10	138896	70	64359756
Vocal cord paralysis	30.74	12.06	30	138876	2116	64357710
Abdominal neoplasm	30.73	12.06	16	138890	408	64359418
Viral load increased	30.56	12.06	32	138874	2455	64357371
Hepatosplenic candidiasis	30.33	12.06	17	138889	504	64359322
Influenza like illness	30.28	12.06	54	138852	61648	64298178
Clonal haematopoiesis	30.23	12.06	7	138899	9	64359817
Therapy responder	30.14	12.06	16	138890	425	64359401
Disorientation	30.06	12.06	46	138860	55782	64304044
Hepatitis B DNA increased	29.89	12.06	18	138888	612	64359214
Premature delivery	29.78	12.06	98	138808	18491	64341335
Eosinophilia	29.78	12.06	23	138883	38053	64321773
Mesenteric abscess	29.74	12.06	11	138895	118	64359708
Anastomotic leak	29.63	12.06	21	138885	945	64358881
Ear infection	29.59	12.06	7	138899	23397	64336429
Osteomyelitis bacterial	29.47	12.06	16	138890	445	64359381
Osteosarcoma	29.45	12.06	14	138892	292	64359534
Bone lesion	29.20	12.06	45	138861	5092	64354734
Abortion spontaneous	29.01	12.06	9	138897	25134	64334692
Metastases to bone marrow	28.92	12.06	18	138888	650	64359176
Meningitis cryptococcal	28.84	12.06	34	138872	2975	64356851
Metastases to pleura	28.81	12.06	23	138883	1241	64358585
Leukoerythroblastosis	28.73	12.06	13	138893	241	64359585
VIth nerve paresis	28.72	12.06	11	138895	131	64359695
Dry mouth	28.65	12.06	54	138852	60364	64299462
Unresponsive to stimuli	28.62	12.06	40	138866	50353	64309473
Metastases to spleen	28.08	12.06	16	138890	490	64359336
Cholelithiasis	28.02	12.06	34	138872	45472	64314354
Migraine	28.01	12.06	58	138848	62619	64297207
Left ventricular dilatation	27.99	12.06	20	138886	912	64358914
Ovarian cancer recurrent	27.70	12.06	14	138892	335	64359491
Chemotherapeutic drug level increased	27.58	12.06	14	138892	338	64359488
Perineal infection	27.55	12.06	14	138892	339	64359487
Product quality issue	27.38	12.06	15	138891	29784	64330042
Adrenocortical carcinoma	27.35	12.06	9	138897	66	64359760
Metastases to meninges	27.30	12.06	32	138874	2783	64357043
Respiratory syncytial virus infection	27.30	12.06	53	138853	7215	64352611
Neutropenic infection	27.27	12.06	27	138879	1938	64357888
T-cell type acute leukaemia	27.18	12.06	11	138895	153	64359673
Oesophageal candidiasis	27.16	12.06	56	138850	7961	64351865
Muscle rigidity	27.05	12.06	3	138903	17470	64342356
Mood swings	27.04	12.06	3	138903	17465	64342361
Rhinovirus infection	27.02	12.06	48	138858	6108	64353718
Enterococcal sepsis	26.98	12.06	30	138876	2464	64357362
Chronic myelomonocytic leukaemia	26.90	12.06	18	138888	737	64359089
Nodular regenerative hyperplasia	26.89	12.06	19	138887	851	64358975
Vena cava thrombosis	26.80	12.06	30	138876	2482	64357344
Dry skin	26.74	12.06	43	138863	51118	64308708
Burning sensation	26.66	12.06	41	138865	49623	64310203
Recall phenomenon	26.62	12.06	20	138886	986	64358840
Myasthenia gravis crisis	26.62	12.06	19	138887	865	64358961
Throat irritation	26.56	12.06	19	138887	32692	64327134
Localised infection	26.55	12.06	16	138890	30145	64329681
Extrapyramidal disorder	26.46	12.06	5	138901	19547	64340279
Stem cell transplant	26.43	12.06	35	138871	3446	64356380
Gastric disorder	26.39	12.06	15	138891	29182	64330644
Bacterial sepsis	26.35	12.06	53	138853	7404	64352422
Eye pain	26.16	12.06	18	138888	31607	64328219
Metastases to soft tissue	26.16	12.06	14	138892	378	64359448
Flatulence	26.09	12.06	23	138883	35643	64324183
Intussusception	26.07	12.06	19	138887	894	64358932
Joint range of motion decreased	26.06	12.06	5	138901	19338	64340488
Type 2 diabetes mellitus	26.04	12.06	21	138885	33999	64325827
Photosensitivity reaction	26.02	12.06	4	138902	18169	64341657
Fungal oesophagitis	25.98	12.06	18	138888	781	64359045
Thyroid dermatopathy	25.86	12.06	7	138899	23	64359803
Eczema	25.83	12.06	16	138890	29704	64330122
Mass	25.80	12.06	82	138824	15194	64344632
Diabetes mellitus inadequate control	25.76	12.06	7	138899	21314	64338512
Heart rate abnormal	25.72	12.06	42	138864	4993	64354833
Biliary-bronchial fistula	25.71	12.06	5	138901	0	64359826
Orthostatic hypotension	25.65	12.06	38	138868	46700	64313126
Oxygen saturation decreased	25.65	12.06	131	138775	107045	64252781
Leukaemic lymphoma	25.64	12.06	9	138897	82	64359744
Red blood cell sedimentation rate increased	25.55	12.06	18	138888	31217	64328609
Carotid intima-media thickness increased	25.45	12.06	9	138897	84	64359742
Crying	25.42	12.06	6	138900	20084	64339742
Body dysmorphic disorder	25.38	12.06	12	138894	247	64359579
Pericarditis	25.36	12.06	61	138845	62455	64297371
Therapy interrupted	25.32	12.06	6	138900	20030	64339796
Subclavian vein thrombosis	25.32	12.06	28	138878	2286	64357540
Vertigo	25.21	12.06	56	138850	58955	64300871
Leukoencephalopathy	25.19	12.06	50	138856	6917	64352909
Acute biphenotypic leukaemia	25.18	12.06	10	138896	132	64359694
Lymphocytosis	25.18	12.06	35	138871	3609	64356217
Nightmare	25.16	12.06	7	138899	20986	64338840
Iron deficiency anaemia	24.96	12.06	8	138898	21881	64337945
Amenorrhoea	24.95	12.06	48	138858	6491	64353335
Meningitis tuberculous	24.86	12.06	20	138886	1091	64358735
Adverse event	24.86	12.06	29	138877	39460	64320366
Cardiac dysfunction	24.78	12.06	32	138874	3074	64356752
Tumour necrosis	24.68	12.06	24	138882	1685	64358141
Diabetic ketoacidosis	24.67	12.06	17	138889	29828	64329998
Ovarian epithelial cancer recurrent	24.63	12.06	6	138900	11	64359815
Rectal haemorrhage	24.54	12.06	61	138845	61756	64298070
Venous thrombosis	24.54	12.06	47	138859	6334	64353492
Pyomyositis	24.52	12.06	15	138891	525	64359301
Skin mass	24.51	12.06	50	138856	7056	64352770
Respiratory tract congestion	24.46	12.06	3	138903	16162	64343664
Infusion site streaking	24.44	12.06	14	138892	433	64359393
Cutaneous T-cell lymphoma recurrent	24.39	12.06	8	138898	58	64359768
Hip fracture	24.38	12.06	14	138892	27085	64332741
Glioblastoma multiforme	24.35	12.06	20	138886	1124	64358702
Respiratory depression	24.30	12.06	10	138896	23433	64336393
Computerised tomogram thorax	24.27	12.06	10	138896	146	64359680
Blood urine present	24.17	12.06	5	138901	18335	64341491
Device related thrombosis	24.15	12.06	26	138880	2059	64357767
Blood potassium increased	23.98	12.06	13	138893	25967	64333859
Coma	23.97	12.06	102	138804	87513	64272313
Eye swelling	23.93	12.06	9	138897	22272	64337554
Marginal zone lymphoma recurrent	23.87	12.06	7	138899	33	64359793
Gallbladder disorder	23.82	12.06	4	138902	17026	64342800
Combined immunodeficiency	23.82	12.06	9	138897	103	64359723
B precursor type acute leukaemia	23.75	12.06	12	138894	287	64359539
Haematochezia	23.71	12.06	69	138837	66304	64293522
Intestinal atresia	23.70	12.06	8	138898	64	64359762
T-cell lymphoma	23.57	12.06	20	138886	1176	64358650
Respiratory distress	23.55	12.06	193	138713	52138	64307688
Hypertension	23.39	12.06	405	138501	258856	64100970
Oedema	23.37	12.06	110	138796	91825	64268001
Epstein Barr virus positive mucocutaneous ulcer	23.36	12.06	16	138890	681	64359145
Renal disorder	23.32	12.06	25	138881	35340	64324486
Sarcoidosis	23.31	12.06	45	138861	6101	64353725
Panic attack	23.29	12.06	8	138898	20945	64338881
Sarcoma metastatic	23.28	12.06	8	138898	68	64359758
Kidney infection	23.23	12.06	5	138901	17833	64341993
Poisoning	23.23	12.06	9	138897	21870	64337956
Blood urea increased	23.18	12.06	37	138869	44116	64315710
Retinal haemorrhage	23.12	12.06	50	138856	7348	64352478
Acute respiratory distress syndrome	22.88	12.06	153	138753	38782	64321044
Acute hepatic failure	22.81	12.06	114	138792	25998	64333828
Ankle brachial index decreased	22.78	12.06	8	138898	73	64359753
Gastrointestinal haemorrhage	22.77	12.06	179	138727	132133	64227693
Disorder of orbit	22.72	12.06	9	138897	118	64359708
Listeria sepsis	22.60	12.06	15	138891	606	64359220
Pulse waveform abnormal	22.59	12.06	8	138898	75	64359751
Tooth disorder	22.51	12.06	10	138896	22392	64337434
Abdominal abscess	22.51	12.06	45	138861	6259	64353567
Blood creatinine increased	22.31	12.06	186	138720	135596	64224230
Hyperferritinaemia	22.26	12.06	14	138892	515	64359311
Cerebral haemangioma	22.18	12.06	9	138897	126	64359700
Herpes simplex encephalitis	22.17	12.06	15	138891	626	64359200
Tendonitis	22.11	12.06	8	138898	20274	64339552
Mucosal disorder	22.05	12.06	30	138876	3032	64356794
Disseminated intravascular coagulation	22.04	12.06	132	138774	32216	64327610
Colitis ulcerative	22.03	12.06	11	138895	23017	64336809
Fear	21.91	12.06	8	138898	20163	64339663
Acute monocytic leukaemia	21.91	12.06	13	138893	430	64359396
Refractory cytopenia with multilineage dysplasia	21.88	12.06	11	138895	260	64359566
Pleuroparenchymal fibroelastosis	21.88	12.06	6	138900	21	64359805
Cardiac arrest	21.86	12.06	219	138687	153845	64205981
Blood HIV RNA increased	21.73	12.06	21	138885	1463	64358363
Klebsiella bacteraemia	21.70	12.06	26	138880	2314	64357512
Medication error	21.69	12.06	47	138859	49919	64309907
Lentigo	21.67	12.06	13	138893	439	64359387
Vascular injury	21.62	12.06	18	138888	1031	64358795
Mediastinum neoplasm	21.62	12.06	8	138898	86	64359740
Fungal infection	21.60	12.06	137	138769	34114	64325712
B-cell type acute leukaemia	21.56	12.06	13	138893	443	64359383
Geotrichum infection	21.56	12.06	17	138889	901	64358925
Hallucination, auditory	21.55	12.06	5	138901	16934	64342892
Cellulitis gangrenous	21.54	12.06	11	138895	269	64359557
Hyperpyrexia	21.53	12.06	39	138867	5038	64354788
Feeling hot	21.48	12.06	41	138865	45622	64314204
Dysgeusia	21.48	12.06	43	138863	47004	64312822
Neoplasm	21.38	12.06	47	138859	6984	64352842
Pulmonary embolism	21.36	12.06	438	138468	145918	64213908
Injection site rash	21.36	12.06	4	138902	15738	64344088
Hot flush	21.33	12.06	42	138864	46193	64313633
Fungaemia	21.30	12.06	33	138873	3752	64356074
Rhabdomyosarcoma	21.21	12.06	9	138897	142	64359684
Duodenal stenosis	21.21	12.06	15	138891	673	64359153
Taeniasis	21.19	12.06	7	138899	52	64359774
Gastroenteritis viral	21.14	12.06	8	138898	19721	64340105
Body temperature decreased	21.13	12.06	15	138891	25913	64333913
Leukaemia recurrent	21.13	12.06	27	138879	2567	64357259
Hypersomnia	21.11	12.06	8	138898	19709	64340117
Encephalitis enteroviral	21.10	12.06	9	138897	144	64359682
Respiratory tract infection fungal	20.99	12.06	18	138888	1074	64358752
Vulvovaginal inflammation	20.95	12.06	13	138893	467	64359359
Procedural pain	20.91	12.06	4	138902	15504	64344322
Quadriplegia	20.91	12.06	29	138877	2984	64356842
Rhabdomyosarcoma recurrent	20.91	12.06	8	138898	95	64359731
Mucoepidermoid carcinoma of salivary gland	20.83	12.06	8	138898	96	64359730
Toxic encephalopathy	20.69	12.06	57	138849	9758	64350068
Trichodysplasia spinulosa	20.67	12.06	15	138891	701	64359125
Erythropenia	20.61	12.06	12	138894	383	64359443
Pneumonia cytomegaloviral	20.57	12.06	35	138871	4304	64355522
Delirium	20.54	12.06	78	138828	69116	64290710
Device dislocation	20.44	12.06	10	138896	21168	64338658
Sneezing	20.43	12.06	4	138902	15247	64344579
Metabolic acidosis	20.42	12.06	81	138825	70877	64288949
Transformation to acute myeloid leukaemia	20.34	12.06	16	138890	845	64358981
Immunosuppression	20.31	12.06	60	138846	10686	64349140
Hormone receptor positive breast cancer	20.23	12.06	11	138895	307	64359519
COVID-19	20.21	12.06	222	138684	64918	64294908
Leukonychia	20.17	12.06	6	138900	30	64359796
Myelitis transverse	20.15	12.06	21	138885	1602	64358224
Enterovirus test positive	20.14	12.06	10	138896	230	64359596
Mental status changes	20.13	12.06	66	138840	61096	64298730
Human rhinovirus test positive	20.03	12.06	12	138894	404	64359422
Coronary artery occlusion	20.02	12.06	3	138903	13888	64345938
Therapeutic response delayed	20.00	12.06	16	138890	866	64358960
Metastases to muscle	19.97	12.06	11	138895	315	64359511
Periorbital cellulitis	19.94	12.06	15	138891	741	64359085
Pyloric stenosis	19.90	12.06	12	138894	409	64359417
Ageusia	19.87	12.06	3	138903	13810	64346016
Neuroborreliosis	19.85	12.06	8	138898	110	64359716
Glycosylated haemoglobin increased	19.85	12.06	5	138901	16014	64343812
Dry eye	19.72	12.06	20	138886	28999	64330827
Upper limb fracture	19.70	12.06	4	138902	14862	64344964
Primary immunodeficiency syndrome	19.64	12.06	7	138899	67	64359759
Stevens-Johnson syndrome	19.63	12.06	27	138879	34222	64325604
Sinus disorder	19.60	12.06	6	138900	16902	64342924
Metastases to pelvis	19.59	12.06	13	138893	525	64359301
Sputum discoloured	19.53	12.06	7	138899	17849	64341977
Laboratory test abnormal	19.51	12.06	14	138892	24049	64335777
Uterine enlargement	19.50	12.06	15	138891	766	64359060
Pneumonia aspiration	19.48	12.06	64	138842	59207	64300619
Abdominal mass	19.42	12.06	28	138878	2987	64356839
Cardiogenic shock	19.40	12.06	128	138778	32299	64327527
Blood pressure diastolic decreased	19.39	12.06	12	138894	22289	64337537
Aplastic anaemia	19.35	12.06	70	138836	13850	64345976
Superior vena cava syndrome	19.21	12.06	17	138889	1058	64358768
Cerebellar haemangioma	19.19	12.06	7	138899	72	64359754
Embolism	19.15	12.06	64	138842	12171	64347655
Amputation stump pain	19.12	12.06	6	138900	37	64359789
Jejunal stenosis	19.10	12.06	7	138899	73	64359753
Oral fungal infection	19.09	12.06	28	138878	3033	64356793
Cerebellar stroke	19.09	12.06	12	138894	441	64359385
Folliculitis	19.02	12.06	22	138884	30055	64329771
Sinus polyp	19.02	12.06	12	138894	444	64359382
Hepatic infarction	18.95	12.06	15	138891	799	64359027
Splenic candidiasis	18.94	12.06	7	138899	75	64359751
Sciatica	18.91	12.06	10	138896	20254	64339572
Movement disorder	18.91	12.06	12	138894	21988	64337838
Creatinine renal clearance decreased	18.86	12.06	4	138902	14417	64345409
Transaminases	18.85	12.06	7	138899	76	64359750
Angina unstable	18.83	12.06	5	138901	15462	64344364
Hyperbilirubinaemia	18.82	12.06	93	138813	21112	64338714
Skin laceration	18.77	12.06	15	138891	24402	64335424
Transplant rejection	18.73	12.06	7	138899	17394	64342432
Sleep apnoea syndrome	18.68	12.06	22	138884	29810	64330016
Positron emission tomogram abnormal	18.62	12.06	10	138896	272	64359554
Vulvovaginitis	18.55	12.06	10	138896	274	64359552
Cardiac failure acute	18.48	12.06	77	138829	16267	64343559
Pregnancy	18.46	12.06	11	138895	20854	64338972
Tissue infiltration	18.44	12.06	13	138893	580	64359246
Cutaneous T-cell lymphoma	18.40	12.06	24	138882	2328	64357498
Gastrointestinal inflammation	18.37	12.06	41	138865	6154	64353672
Enterovirus infection	18.36	12.06	19	138887	1438	64358388
Neurofibrosarcoma	18.25	12.06	9	138897	204	64359622
Haemoptysis	18.25	12.06	50	138856	48998	64310828
Dysaesthesia	18.25	12.06	36	138870	4959	64354867
Paranasal sinus mucosal hypertrophy	18.23	12.06	7	138899	84	64359742
Pathogen resistance	18.22	12.06	64	138842	12479	64347347
Bicytopenia	18.21	12.06	30	138876	3592	64356234
Liver function test increased	18.17	12.06	24	138882	30946	64328880
Premature ageing	18.08	12.06	7	138899	86	64359740
Leukaemia cutis	18.05	12.06	8	138898	141	64359685
Pulmonary alveolar haemorrhage	18.05	12.06	54	138852	9684	64350142
Blood glucose decreased	18.04	12.06	14	138892	23109	64336717
Therapeutic response unexpected	18.04	12.06	7	138899	16994	64342832
Radiation skin injury	17.95	12.06	18	138888	1312	64358514
Clostridium test positive	17.95	12.06	32	138874	4083	64355743
Hypersensitivity pneumonitis	17.94	12.06	28	138878	3204	64356622
Osteoporosis	17.92	12.06	40	138866	42040	64317786
Bladder perforation	17.92	12.06	10	138896	294	64359532
Blood loss anaemia	17.87	12.06	4	138902	13888	64345938
Chromosome analysis abnormal	17.82	12.06	9	138897	215	64359611
Hepatosplenomegaly	17.72	12.06	37	138869	5306	64354520
Hepatic amoebiasis	17.72	12.06	7	138899	91	64359735
Thrombocytopenia neonatal	17.71	12.06	5	138901	20	64359806
Basal ganglion degeneration	17.68	12.06	11	138895	397	64359429
Secondary cerebellar degeneration	17.67	12.06	6	138900	49	64359777
Pneumonia salmonella	17.67	12.06	6	138900	49	64359777
Evans syndrome	17.65	12.06	11	138895	398	64359428
Salivary gland neoplasm	17.65	12.06	7	138899	92	64359734
Spindle cell sarcoma	17.63	12.06	9	138897	220	64359606
Disturbance in attention	17.53	12.06	39	138867	41035	64318791
Gastric pneumatosis	17.52	12.06	5	138901	21	64359805
Helicobacter sepsis	17.52	12.06	5	138901	21	64359805
Anger	17.51	12.06	6	138900	15735	64344091
Pulmonary vein stenosis	17.50	12.06	8	138898	152	64359674
Pseudocirrhosis	17.46	12.06	13	138893	632	64359194
Hypertransaminasaemia	17.44	12.06	44	138862	7147	64352679
Candida endophthalmitis	17.36	12.06	8	138898	155	64359671
Papillary thyroid cancer	17.29	12.06	23	138883	2275	64357551
Disseminated cytomegaloviral infection	17.27	12.06	11	138895	414	64359412
Pulmonary hypoplasia	17.26	12.06	6	138900	53	64359773
Splenic necrosis	17.19	12.06	7	138899	99	64359727
Poor venous access	17.18	12.06	3	138903	12414	64347412
Ocular hyperaemia	17.18	12.06	14	138892	22550	64337276
Hernia	17.18	12.06	4	138902	13514	64346312
Acute pulmonary histoplasmosis	17.16	12.06	9	138897	233	64359593
Splenic marginal zone lymphoma	17.15	12.06	5	138901	23	64359803
Frequent bowel movements	17.13	12.06	9	138897	18296	64341530
Toxic neuropathy	17.12	12.06	14	138892	782	64359044
Radiation necrosis	17.10	12.06	10	138896	322	64359504
Pharyngeal inflammation	17.08	12.06	15	138891	924	64358902
Bacterial translocation	17.08	12.06	11	138895	422	64359404
Sphingomonas paucimobilis infection	17.06	12.06	7	138899	101	64359725
Rash erythematous	17.05	12.06	51	138855	48582	64311244
Hypertensive crisis	17.04	12.06	9	138897	18239	64341587
Diverticulitis	17.03	12.06	36	138870	38582	64321244
Dysarthria	16.97	12.06	68	138838	59338	64300488
Synovial sarcoma	16.97	12.06	6	138900	56	64359770
Urinary retention	16.96	12.06	52	138854	49149	64310677
Photophobia	16.94	12.06	8	138898	17285	64342541
Plasma cell myeloma refractory	16.94	12.06	7	138899	103	64359723
Ventricular dysfunction	16.91	12.06	36	138870	5234	64354592
Peritonitis viral	16.87	12.06	6	138900	57	64359769
Hypercholesterolaemia	16.86	12.06	6	138900	15367	64344459
Abdominal wound dehiscence	16.85	12.06	9	138897	242	64359584
Chronic hepatitis	16.82	12.06	17	138889	1251	64358575
Mucosal infection	16.80	12.06	11	138895	434	64359392
Hepatic fibrosis	16.76	12.06	37	138869	5515	64354311
Guillain-Barre syndrome	16.75	12.06	45	138861	7590	64352236
Systolic dysfunction	16.75	12.06	27	138879	3175	64356651
Campylobacter gastroenteritis	16.74	12.06	16	138890	1100	64358726
Blood potassium decreased	16.72	12.06	39	138867	40360	64319466
Miosis	16.71	12.06	4	138902	13262	64346564
Prescribed underdose	16.65	12.06	9	138897	18006	64341820
Rotator cuff syndrome	16.59	12.06	3	138903	12104	64347722
Pulmonary artery stenosis	16.58	12.06	7	138899	109	64359717
Molluscum contagiosum	16.52	12.06	11	138895	447	64359379
Squamous cell carcinoma of head and neck	16.46	12.06	9	138897	254	64359572
Gingivitis ulcerative	16.46	12.06	9	138897	254	64359572
Streptococcal infection	16.33	12.06	44	138862	7435	64352391
Dyskinesia	16.32	12.06	38	138868	39350	64320476
Humoral immune defect	16.30	12.06	7	138899	114	64359712
Candida pneumonia	16.28	12.06	11	138895	458	64359368
Blood pressure diastolic abnormal	16.23	12.06	3	138903	11914	64347912
Ecchymosis	16.21	12.06	5	138901	14017	64345809
Granulomatous pneumonitis	16.17	12.06	6	138900	65	64359761
Suspected product quality issue	16.11	12.06	9	138897	265	64359561
Pneumaturia	16.05	12.06	5	138901	30	64359796
Spinal stenosis	16.05	12.06	5	138901	13926	64345900
Opsoclonus myoclonus	16.04	12.06	8	138898	186	64359640
Human polyomavirus infection	16.03	12.06	15	138891	1004	64358822
Chronic lymphocytic leukaemia refractory	16.02	12.06	7	138899	119	64359707
Cerebral aspergillosis	16.01	12.06	19	138887	1674	64358152
Metastases to abdominal wall	15.97	12.06	7	138899	120	64359706
Mucoepidermoid carcinoma	15.93	12.06	6	138900	68	64359758
Epstein-Barr virus associated lymphoproliferative disorder	15.91	12.06	26	138880	3093	64356733
Haemoglobin abnormal	15.90	12.06	38	138868	5966	64353860
Wound evisceration	15.87	12.06	7	138899	122	64359704
Grip strength decreased	15.86	12.06	3	138903	11721	64348105
Tidal volume decreased	15.85	12.06	6	138900	69	64359757
Blood calcium decreased	15.83	12.06	19	138887	25535	64334291
Splenic lesion	15.83	12.06	10	138896	371	64359455
Myeloproliferative neoplasm	15.77	12.06	14	138892	875	64358951
Bone marrow necrosis	15.77	12.06	8	138898	193	64359633
Pneumoperitoneum	15.77	12.06	24	138882	2687	64357139
Femur fracture	15.75	12.06	31	138875	34104	64325722
Respiratory rate increased	15.75	12.06	10	138896	18321	64341505
Lung adenocarcinoma	15.73	12.06	41	138865	6792	64353034
Extramedullary haemopoiesis	15.71	12.06	7	138899	125	64359701
BRCA2 gene mutation	15.70	12.06	6	138900	71	64359755
Primary mediastinal large B-cell lymphoma recurrent	15.70	12.06	6	138900	71	64359755
Ichthyosis	15.66	12.06	7	138899	126	64359700
Hepatic infection fungal	15.66	12.06	8	138898	196	64359630
Metastases to abdominal cavity	15.62	12.06	11	138895	490	64359336
Hepatitis viral	15.55	12.06	14	138892	891	64358935
Right ventricular failure	15.52	12.06	14	138892	21457	64338369
Rectal fissure	15.50	12.06	13	138893	752	64359074
Fusarium infection	15.49	12.06	18	138888	1551	64358275
Lymphadenopathy mediastinal	15.46	12.06	29	138877	3847	64355979
Platelet count abnormal	15.46	12.06	30	138876	4082	64355744
Joint ankylosis	15.44	12.06	13	138893	756	64359070
Drug level decreased	15.44	12.06	3	138903	11500	64348326
Omental infarction	15.43	12.06	3	138903	0	64359826
Meningoencephalitis viral	15.40	12.06	10	138896	389	64359437
Poor quality sleep	15.39	12.06	11	138895	18940	64340886
Glaucoma	15.36	12.06	8	138898	16340	64343486
Sinus congestion	15.35	12.06	7	138899	15432	64344394
Adenocarcinoma gastric	15.25	12.06	18	138888	1577	64358249
Acanthosis	15.24	12.06	10	138896	396	64359430
Morphoea	15.24	12.06	10	138896	396	64359430
Joint effusion	15.23	12.06	5	138901	13468	64346358
Scedosporium infection	15.17	12.06	16	138890	1238	64358588
Adenovirus infection	15.16	12.06	42	138864	7213	64352613
Mydriasis	15.13	12.06	7	138899	15305	64344521
Cancer fatigue	15.12	12.06	6	138900	79	64359747
Scar	15.09	12.06	5	138901	13393	64346433
Fracture	15.09	12.06	11	138895	18744	64341082
Metapneumovirus bronchiolitis	15.05	12.06	4	138902	12	64359814
Failure to thrive	15.04	12.06	53	138853	10351	64349475
Acute lymphocytic leukaemia refractory	15.04	12.06	7	138899	139	64359687
Right ventricular dysfunction	14.98	12.06	21	138885	2182	64357644
Inflammation	14.96	12.06	81	138825	65219	64294607
Product storage error	14.95	12.06	5	138901	13313	64346513
Torulopsis infection	14.92	12.06	5	138901	39	64359787
Scrotal abscess	14.91	12.06	10	138896	411	64359415
Azoospermia	14.90	12.06	7	138899	142	64359684
Chromaturia	14.89	12.06	16	138890	22595	64337231
Metastases to eye	14.88	12.06	8	138898	218	64359608
Angioimmunoblastic T-cell lymphoma	14.87	12.06	10	138896	413	64359413
Chest discomfort	14.87	12.06	169	138737	115937	64243889
Necrosis	14.85	12.06	45	138861	8126	64351700
Lewis-Sumner syndrome	14.81	12.06	5	138901	40	64359786
Mood altered	14.74	12.06	8	138898	15971	64343855
Pulmonary sarcoidosis	14.70	12.06	15	138891	1116	64358710
Abdominal distension	14.65	12.06	134	138772	95860	64263966
Sudden death	14.65	12.06	13	138893	20083	64339743
Ventricular internal diameter abnormal	14.64	12.06	7	138899	148	64359678
Oligohydramnios	14.54	12.06	25	138881	3099	64356727
Deafness	14.54	12.06	78	138828	18281	64341545
Triple negative breast cancer	14.54	12.06	6	138900	88	64359738
Heavy menstrual bleeding	14.52	12.06	4	138902	12073	64347753
Atypical haemolytic uraemic syndrome	14.52	12.06	12	138894	680	64359146
Pleural neoplasm	14.46	12.06	8	138898	231	64359595
Deafness bilateral	14.46	12.06	19	138887	1857	64357969
Secretion discharge	14.32	12.06	4	138902	11960	64347866
Performance status decreased	14.26	12.06	34	138872	5330	64354496
Respiratory tract infection	14.25	12.06	133	138773	37274	64322552
Large intestine polyp	14.19	12.06	3	138903	10834	64348992
Lymph node pain	14.17	12.06	16	138890	1336	64358490
Beta 2 microglobulin decreased	14.17	12.06	4	138902	16	64359810
Noctiphobia	14.17	12.06	4	138902	16	64359810
Cryptococcal fungaemia	14.14	12.06	7	138899	160	64359666
Head discomfort	14.08	12.06	4	138902	11830	64347996
Osteopenia	14.02	12.06	8	138898	15532	64344294
Metastases to vagina	13.98	12.06	4	138902	17	64359809
Synovial sarcoma metastatic	13.98	12.06	4	138902	17	64359809
Delusion	13.93	12.06	11	138895	18003	64341823
Pneumonitis chemical	13.91	12.06	9	138897	348	64359478
Enterocolitis	13.89	12.06	57	138849	11961	64347865
Disseminated cryptococcosis	13.86	12.06	17	138889	1550	64358276
Device issue	13.86	12.06	17	138889	22631	64337195
Metastatic neoplasm	13.86	12.06	30	138876	4412	64355414
Hypothalamo-pituitary disorder	13.85	12.06	14	138892	1030	64358796
Invasive breast carcinoma	13.84	12.06	10	138896	464	64359362
Small intestinal perforation	13.83	12.06	22	138884	2558	64357268
Musculoskeletal discomfort	13.82	12.06	9	138897	16268	64343558
Restless legs syndrome	13.82	12.06	10	138896	17106	64342720
Osteolysis	13.80	12.06	23	138883	2780	64357046
Deep vein thrombosis	13.80	12.06	310	138596	104872	64254954
Metastases to ovary	13.78	12.06	8	138898	254	64359572
Hyperviscosity syndrome	13.77	12.06	9	138897	354	64359472
Peripheral coldness	13.75	12.06	6	138900	13578	64346248
Encephalitis viral	13.74	12.06	21	138885	2359	64357467
Granulomatous liver disease	13.74	12.06	15	138891	1207	64358619
Rib fracture	13.73	12.06	19	138887	24019	64335807
Dyspepsia	13.65	12.06	109	138797	80203	64279623
Melaena	13.65	12.06	64	138842	53484	64306342
Acute leukaemia	13.60	12.06	17	138889	1581	64358245
Streptococcal bacteraemia	13.57	12.06	24	138882	3043	64356783
Metastases to pancreas	13.53	12.06	10	138896	481	64359345
Klebsiella sepsis	13.51	12.06	22	138884	2610	64357216
Impaired work ability	13.50	12.06	8	138898	15211	64344615
Muscular weakness	13.46	12.06	193	138713	127145	64232681
Malignant neoplasm of orbit	13.45	12.06	4	138902	20	64359806
Vascular compression	13.39	12.06	8	138898	268	64359558
Hypoglossal nerve paresis	13.37	12.06	6	138900	109	64359717
Herpes simplex reactivation	13.37	12.06	8	138898	269	64359557
Endothelial dysfunction	13.36	12.06	7	138899	181	64359645
Increased liver stiffness	13.36	12.06	3	138903	3	64359823
Eating disorder	13.33	12.06	10	138896	16795	64343031
Dermatitis allergic	13.32	12.06	8	138898	15101	64344725
Hyperlipidaemia	13.28	12.06	18	138888	22958	64336868
Herpes zoster	13.25	12.06	242	138664	78945	64280881
Rash macular	13.25	12.06	19	138887	23666	64336160
Hypophagia	13.25	12.06	137	138769	39450	64320376
Metastases to uterus	13.25	12.06	5	138901	57	64359769
Urethritis	13.22	12.06	10	138896	498	64359328
Extravasation blood	13.21	12.06	9	138897	380	64359446
Anaphylactic reaction	13.20	12.06	90	138816	68574	64291252
Cyanosis	13.17	12.06	17	138889	22138	64337688
Adenoviral haemorrhagic cystitis	13.17	12.06	10	138896	501	64359325
Eye irritation	13.15	12.06	9	138897	15847	64343979
Hypercalcaemia	13.14	12.06	114	138792	31302	64328524
Mediastinal fibrosis	13.13	12.06	4	138902	22	64359804
Cryptosporidiosis infection	13.12	12.06	11	138895	636	64359190
Post procedural complication	13.10	12.06	16	138890	21337	64338489
H1N1 influenza	13.09	12.06	20	138886	2246	64357580
Lymphoedema	13.08	12.06	49	138857	9856	64349970
Non-cirrhotic portal hypertension	13.08	12.06	9	138897	386	64359440
Hip deformity	13.08	12.06	7	138899	189	64359637
Pseudomonal bacteraemia	13.07	12.06	20	138886	2249	64357577
Blood culture positive	13.07	12.06	42	138864	7826	64352000
Mediastinal mass	13.07	12.06	10	138896	507	64359319
Mitral valve incompetence	13.04	12.06	97	138809	25441	64334385
Systemic inflammatory response syndrome	13.00	12.06	50	138856	10185	64349641
Facial paresis	12.99	12.06	31	138875	4861	64354965
Intervertebral disc degeneration	12.96	12.06	6	138900	13114	64346712
PIK3CA-activated mutation	12.93	12.06	10	138896	515	64359311
Empyema	12.89	12.06	26	138880	3639	64356187
Blood triglycerides increased	12.82	12.06	13	138893	18853	64340973
Stomatitis necrotising	12.82	12.06	7	138899	197	64359629
Dystonia	12.82	12.06	13	138893	18852	64340974
Metastases to the mediastinum	12.78	12.06	10	138896	524	64359302
Mantle cell lymphoma	12.75	12.06	14	138892	1134	64358692
Tuberculosis liver	12.73	12.06	5	138901	64	64359762
Systemic mycosis	12.72	12.06	20	138886	2303	64357523
Infected neoplasm	12.70	12.06	8	138898	295	64359531
Dysplasia	12.69	12.06	14	138892	1140	64358686
Minimal residual disease	12.64	12.06	9	138897	408	64359418
Angina pectoris	12.63	12.06	52	138854	45029	64314797
Wrist fracture	12.63	12.06	3	138903	9998	64349828
Blindness	12.62	12.06	86	138820	21933	64337893
Anaesthesia	12.60	12.06	9	138897	410	64359416
Procedural pneumothorax	12.59	12.06	5	138901	66	64359760
Drug eruption	12.59	12.06	38	138868	36098	64323728
Obstructive airways disorder	12.58	12.06	19	138887	23166	64336660
Listeria encephalitis	12.56	12.06	8	138898	301	64359525
Splenic infarction	12.54	12.06	24	138882	3233	64356593
Bone density decreased	12.54	12.06	3	138903	9949	64349877
Paraplegia	12.52	12.06	29	138877	4461	64355365
Vessel puncture site bruise	12.51	12.06	9	138897	415	64359411
Tooth fracture	12.49	12.06	3	138903	9924	64349902
Liver abscess	12.48	12.06	32	138874	5248	64354578
T-cell lymphoma recurrent	12.46	12.06	5	138901	68	64359758
Neutrophilic dermatosis	12.44	12.06	10	138896	545	64359281
Large intestine perforation	12.44	12.06	57	138849	12547	64347279
Cardiac failure congestive	12.41	12.06	202	138704	130378	64229448
Vaginal haemorrhage	12.40	12.06	14	138892	19330	64340496
Paresis	12.35	12.06	25	138881	3507	64356319
Diabetes mellitus	12.35	12.06	88	138818	66386	64293440
Tenosynovitis	12.34	12.06	5	138901	11828	64347998
Oral candidiasis	12.33	12.06	89	138817	23123	64336703
Ear pain	12.33	12.06	22	138884	25114	64334712
Acute hepatitis C	12.32	12.06	7	138899	213	64359613
Product intolerance	12.31	12.06	4	138902	28	64359798
Ligament sprain	12.31	12.06	4	138902	10848	64348978
Adult T-cell lymphoma/leukaemia	12.30	12.06	8	138898	312	64359514
Central nervous system infection	12.30	12.06	14	138892	1180	64358646
Feeling cold	12.28	12.06	20	138886	23658	64336168
B-lymphocyte count abnormal	12.26	12.06	5	138901	71	64359755
Mental disorder	12.22	12.06	24	138882	26421	64333405
Adenocarcinoma of appendix	12.20	12.06	5	138901	72	64359754
Incorrect product administration duration	12.18	12.06	3	138903	9755	64350071
Seasonal allergy	12.16	12.06	5	138901	11721	64348105
Gout	12.15	12.06	17	138889	21396	64338430
Extraskeletal myxoid chondrosarcoma	12.15	12.06	3	138903	6	64359820
Acute myocardial infarction	12.14	12.06	94	138812	69624	64290202
Parkinsonism	12.13	12.06	8	138898	14365	64345461
Malignant ascites	12.12	12.06	13	138893	1025	64358801
Device use error	12.10	12.06	36	138870	6435	64353391
Cancer in remission	12.08	12.06	4	138902	30	64359796
Selective mutism	12.07	12.06	5	138901	74	64359752
Hip arthroplasty	12.07	12.06	17	138889	21334	64338492

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01DB01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES Anthracyclines and related substances
FDA CS	M0028312	Anthracyclines
FDA MoA	N0000000176	Topoisomerase Inhibitors
FDA EPC	N0000175414	Anthracycline Topoisomerase Inhibitor
MeSH PA	D000903	Antibiotics, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D059005	Topoisomerase II Inhibitors
CHEBI has role	CHEBI:76971	Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute lymphoid leukemia	indication	91857003	DOID:9952
Acute myeloid leukemia, disease	indication	91861009
Kaposi's sarcoma	indication	109385007
Diffuse non-Hodgkin's lymphoma, large cell	indication	109969005
Multiple myeloma	indication	109989006	DOID:9538
Hodgkin's disease	indication	118599009
Non-Hodgkin's lymphoma	indication	118601006
Burkitt's lymphoma	indication	118617000
Small cell carcinoma of lung	indication	254632001	DOID:5409
Carcinoma of breast	indication	254838004	DOID:3459
Nephroblastoma	indication	302849000	DOID:2154
Osteosarcoma of bone	indication	307576001	DOID:3376
Follicular non-Hodgkin's lymphoma	indication	308121000
Malignant tumor of lung	indication	363358000
Malignant tumor of ovary	indication	363443007	DOID:2394
Malignant tumor of thyroid gland	indication	363478007	DOID:1781
Kaposi's sarcoma associated with AIDS	indication	420524008
Neuroblastoma	indication	432328008	DOID:769
Carcinoma of female breast	indication	447782002
Soft or Connective Tissue Sarcoma	indication
Invasive Bladder Malignancy	indication
Metastatic Breast Carcinoma	indication
Metastatic Gastric Cancer	indication
Carcinoid syndrome	off-label use	35868009
Ewing's sarcoma	off-label use	76909002	DOID:3369
Chronic lymphoid leukemia, disease	off-label use	92814006
Malignant neoplasm of liver	off-label use	93870000	DOID:3571
Endometrial carcinoma	off-label use	254878006	DOID:2871
Malignant tumor of head and/or neck	off-label use	255056009
Primary cutaneous T-cell lymphoma	off-label use	400122007
Adenocarcinoma of pancreas	off-label use	700423003	DOID:4074
Pancreatic Neuroendocrine Tumor	off-label use	717919005
Mycosis	contraindication	3218000	DOID:1564
Bundle branch block	contraindication	6374002
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Viral disease	contraindication	34014006	DOID:934
Hyperuricemia	contraindication	35885006	DOID:1920
Conduction disorder of the heart	contraindication	44808001
Myocarditis	contraindication	50920009	DOID:820
Heart disease	contraindication	56265001	DOID:114
Hepatic failure	contraindication	59927004
Heart failure	contraindication	84114007	DOID:6000
Leukopenia	contraindication	84828003	DOID:615
Cardiomyopathy	contraindication	85898001	DOID:0050700
Bacterial infectious disease	contraindication	87628006
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Atrioventricular block	contraindication	233917008	DOID:0050820
Disease of liver	contraindication	235856003	DOID:409
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Breastfeeding (mother)	contraindication	413712001
Myocardial infarction in recovery phase	contraindication	418044006
Asymptomatic left ventricular systolic dysfunction	contraindication	698592004
Protozoal Infection	contraindication
Severe Cardiac Disease	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.85	acidic
pKa2	9.21	acidic
pKa3	9.92	acidic
pKa4	11.11	acidic
pKa5	8.6	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
DNA topoisomerase 2-alpha	Enzyme	P11388	TOP2A_HUMAN	INHIBITOR	IC50	6	CHEMBL	CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		IC50	4.01	CHEMBL
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.43	DRUG MATRIX
Canalicular multispecific organic anion transporter 1	Transporter	Q92887	MRP2_HUMAN				WOMBAT-PK
Multidrug resistance-associated protein 1	Transporter	P33527	MRP1_HUMAN				WOMBAT-PK
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN				WOMBAT-PK
Multidrug resistance-associated protein 6	Transporter	O95255	MRP6_HUMAN				WOMBAT-PK
Caspase-1	Enzyme	P29466	CASP1_HUMAN		IC50	4.91	DRUG MATRIX
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		IC50	4.50	DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	5.29	DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2	Kinase	P04626	ERBB2_HUMAN		IC50	5.61	DRUG MATRIX
72 kDa type IV collagenase	Enzyme	P08253	MMP2_HUMAN		IC50	5.96	CHEMBL
DNA topoisomerase 1	Enzyme	P11387	TOP1_HUMAN		IC50	4.70	CHEMBL
Telomerase reverse transcriptase	Enzyme	O14746	TERT_HUMAN		IC50	4.14	CHEMBL
DNA topoisomerase 2-beta	Enzyme	Q02880	TOP2B_HUMAN		IC50	5.46	CHEMBL
Aurora kinase A	Kinase	O14965	AURKA_HUMAN		IC50	7.40	CHEMBL
CDGSH iron-sulfur domain-containing protein 1	Unclassified	Q9NZ45	CISD1_HUMAN		Ki	5.46	CHEMBL
Ribonuclease pancreatic	Enzyme		RNAS1_BOVIN		IC50	4.60	CHEMBL
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	4.87	DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	4.81	DRUG MATRIX
Integrase	Enzyme		Q7ZJM1_9HIV1		IC50	6.05	CHEMBL
Reverse transcriptase/RNaseH	Enzyme		Q72547_9HIV1		IC50	4.28	CHEMBL
Reverse transcriptase	Enzyme		Q9WKE8_9HIV1		IC50	4.28	CHEMBL
Type-2 restriction enzyme HindIII	Unclassified		T2D3_HAEIN		IC50	4.02	CHEMBL
Type-2 restriction enzyme ScaI	Unclassified		T2S1_STRCS		IC50	4.60	CHEMBL
ORF 73	Unclassified		O40947_HHV8		AC50	5.84	CHEMBL
UDP-galactopyranose mutase	Enzyme		GLF_MYCTU		AC50	4.49	CHEMBL
5-hydroxytryptamine receptor 4	GPCR		5HT4R_CAVPO		Ki	5.68	DRUG MATRIX
DNA	Enzyme		DNM3A_MOUSE		IC50	5.52	CHEMBL

External reference:

ID	Source
4019737	VUID
N0000147829	NUI
D01275	KEGG_DRUG
25316-40-9	SECONDARY_CAS_RN
4018106	VANDF
4019737	VANDF
C0013089	UMLSCUI
CHEBI:28748	CHEBI
DM2	PDB_CHEM_ID
CHEMBL53463	ChEMBL_ID
CHEMBL359744	ChEMBL_ID
D004317	MESH_DESCRIPTOR_UI
DB00997	DRUGBANK_ID
C506643	MESH_SUPPLEMENTAL_RECORD_UI
7069	IUPHAR_LIGAND_ID
3005	INN_ID
80168379AG	UNII
31703	PUBCHEM_CID
142433	RXNORM
3368	MMSL
4639	MMSL
47543	MMSL
47549	MMSL
d00218	MMSL
d04004	MMSL
002659	NDDF
004818	NDDF
372817009	SNOMEDCT_US
428681007	SNOMEDCT_US
68444001	SNOMEDCT_US
90875009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-3030	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	34 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-3031	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	34 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-3032	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	34 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-3033	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	34 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-3034	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	34 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-4004	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	33 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-4015	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	33 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-4026	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	33 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0069-4037	INJECTION, SOLUTION	2 mg	INTRAVENOUS	NDA	33 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9084	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9085	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9086	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9087	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9088	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9089	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9090	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9091	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9092	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Doxorubicin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9093	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2 mg	INTRAVENOUS	ANDA	27 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9275	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9277	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9369	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9370	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9371	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9372	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9546	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9547	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9548	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
Adriamycin	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9549	INJECTION, SOLUTION	2 mg	INTRAVENOUS	ANDA	26 sections
DOXIL	HUMAN PRESCRIPTION DRUG LABEL	1	0338-0063	INJECTION, SUSPENSION, LIPOSOMAL	2 mg	INTRAVENOUS	NDA	26 sections