doxorubicin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 960 23214-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxorubicin
  • hydroxydaunomycin
  • hydroxydaunorubicin
  • rubidox
  • doxorubicin hydrochloride
  • liposomal doxorubicin
  • hydroxydaunorubicin hydrochloride
  • adriamycin
  • doxorubicin HCl
  • hydroxydaunorubicin HCl
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
  • Molecular weight: 543.53
  • Formula: C27H29NO11
  • CLOGP: 0.32
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 6
  • TPSA: 206.07
  • ALOGS: -2.67
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.47 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.28 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 32 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1974 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4704.78 11.94 2722 92638 91905 46498797
Neutropenia 2502.00 11.94 2176 93184 141028 46449674
Acute myeloid leukaemia 1027.01 11.94 544 94816 15234 46575468
Mucosal inflammation 931.85 11.94 713 94647 38263 46552439
Cardiotoxicity 794.50 11.94 349 95011 6373 46584329
Myelodysplastic syndrome 789.88 11.94 457 94903 15254 46575448
Palmar-plantar erythrodysaesthesia syndrome 756.82 11.94 489 94871 19962 46570740
Second primary malignancy 717.70 11.94 323 95037 6261 46584441
Disease progression 648.06 11.94 863 94497 90437 46500265
Product use in unapproved indication 641.83 11.94 854 94506 89419 46501283
Thrombocytopenia 627.76 11.94 1010 94350 125571 46465131
Bone marrow failure 583.18 11.94 484 94876 29185 46561517
Haematotoxicity 582.11 11.94 284 95076 6649 46584053
Malignant neoplasm progression 577.26 11.94 687 94673 64239 46526463
Febrile bone marrow aplasia 490.40 11.94 252 95108 6610 46584092
Rheumatoid arthritis 459.47 11.94 6 95354 240209 46350493
Pancytopenia 457.68 11.94 705 94655 84353 46506349
Ejection fraction decreased 452.37 11.94 339 95021 17598 46573104
Cardiomyopathy 446.46 11.94 322 95038 15751 46574951
Diffuse large B-cell lymphoma recurrent 441.51 11.94 151 95209 1341 46589361
Pneumocystis jirovecii pneumonia 415.60 11.94 302 95058 14946 46575756
Off label use 370.37 11.94 1644 93716 378197 46212505
Neoplasm progression 367.08 11.94 356 95004 26327 46564375
Fall 333.48 11.94 128 95232 328969 46261733
Left ventricular dysfunction 332.72 11.94 226 95134 10029 46580673
Ovarian failure 321.09 11.94 111 95249 1021 46589681
Anaemia 316.88 11.94 1193 94167 254586 46336116
Pyrexia 307.29 11.94 1466 93894 347336 46243366
Tumour lysis syndrome 289.88 11.94 182 95178 7054 46583648
Completed suicide 277.26 11.94 4 95356 145916 46444786
Neutrophil count decreased 273.76 11.94 388 94972 43038 46547664
Metastases to bone 268.65 11.94 248 95112 17228 46573474
Leukopenia 268.03 11.94 492 94868 67851 46522851
Neutropenic sepsis 267.23 11.94 213 95147 12111 46578591
Joint swelling 260.33 11.94 21 95339 166052 46424650
Septic shock 255.62 11.94 439 94921 57454 46533248
Cardiac failure 250.92 11.94 524 94836 79424 46511278
Drug hypersensitivity 241.56 11.94 98 95262 243727 46346975
Ovarian cancer 238.73 11.94 148 95212 5607 46585095
Hepatitis B 236.39 11.94 126 95234 3567 46587135
Headache 236.31 11.94 384 94976 477968 46112734
Neuropathy peripheral 233.67 11.94 550 94810 90343 46500359
Stomatitis 230.09 11.94 461 94899 67836 46522866
Sepsis 216.42 11.94 690 94670 135324 46455378
Pain 213.67 11.94 407 94953 476541 46114161
Product dose omission issue 210.18 11.94 44 95316 168476 46422226
Metastases to lung 209.01 11.94 174 95186 10522 46580180
Ovarian cancer recurrent 203.73 11.94 77 95283 934 46589768
Diffuse large B-cell lymphoma 197.71 11.94 133 95227 5805 46584897
Diffuse large B-cell lymphoma refractory 196.36 11.94 74 95286 890 46589812
Staphylococcal bacteraemia 193.05 11.94 122 95238 4782 46585920
Metastases to liver 190.10 11.94 217 95143 19368 46571334
Posterior reversible encephalopathy syndrome 189.63 11.94 192 95168 14949 46575753
Bone pain 184.31 11.94 338 95022 46552 46544150
Peripheral sensory neuropathy 180.38 11.94 131 95229 6472 46584230
Weight increased 176.48 11.94 58 95302 164415 46426287
Abdominal discomfort 171.78 11.94 48 95312 151117 46439585
Peripheral swelling 170.90 11.94 55 95305 158016 46432686
Drug ineffective 170.76 11.94 760 94600 677078 45913624
Neurotoxicity 170.07 11.94 173 95187 13544 46577158
Pruritus 168.96 11.94 148 95212 242204 46348498
Breast cancer metastatic 165.03 11.94 170 95190 13508 46577194
Dizziness 164.31 11.94 277 95083 340137 46250565
Acute promyelocytic leukaemia 163.63 11.94 64 95296 857 46589845
Neutropenic colitis 162.44 11.94 83 95277 2149 46588553
Nasopharyngitis 162.26 11.94 56 95304 153942 46436760
Arthralgia 161.40 11.94 313 95047 364290 46226412
Congestive cardiomyopathy 159.84 11.94 115 95245 5598 46585104
Pleural effusion 152.59 11.94 443 94917 82509 46508193
Injection site pain 148.85 11.94 21 95339 107131 46483571
Psoriasis 141.91 11.94 4 95356 78600 46512102
Contraindicated product administered 141.00 11.94 5 95355 79942 46510760
Anti-Muellerian hormone level decreased 138.79 11.94 34 95326 70 46590632
Ascites 137.84 11.94 259 95101 36325 46554377
Hepatitis B reactivation 136.07 11.94 65 95295 1449 46589253
Insomnia 135.16 11.94 85 95275 164839 46425863
Musculoskeletal stiffness 134.26 11.94 20 95340 97973 46492729
Somnolence 133.40 11.94 77 95283 156444 46434258
White blood cell count decreased 133.14 11.94 517 94843 111714 46478988
Progressive multifocal leukoencephalopathy 131.46 11.94 138 95222 11208 46579494
Pneumonitis 128.64 11.94 218 95142 28202 46562500
Disease recurrence 128.28 11.94 173 95187 18298 46572404
Platelet count decreased 127.92 11.94 472 94888 99552 46491150
Myelosuppression 125.57 11.94 113 95247 7590 46583112
Post transplant lymphoproliferative disorder 125.11 11.94 85 95275 3771 46586931
Feeling abnormal 124.12 11.94 50 95310 125010 46465692
B-cell lymphoma recurrent 121.13 11.94 42 95318 390 46590312
Overdose 120.33 11.94 30 95330 101949 46488753
Anxiety 119.77 11.94 117 95243 181840 46408862
Intentional overdose 118.37 11.94 3 95357 64941 46525761
Interstitial lung disease 117.95 11.94 307 95053 53642 46537060
Cytopenia 113.13 11.94 107 95253 7661 46583041
Pain in extremity 112.64 11.94 224 95136 258456 46332246
Systemic lupus erythematosus 111.81 11.94 5 95355 65175 46525527
Aplasia 111.69 11.94 77 95283 3499 46587203
Drug abuse 111.69 11.94 4 95356 63404 46527298
Muscle spasms 111.56 11.94 56 95304 123057 46467645
Sinusitis 107.51 11.94 66 95294 129702 46461000
Skin toxicity 105.55 11.94 75 95285 3579 46587123
Premature menopause 104.15 11.94 43 95317 668 46590034
Premature delivery 103.49 11.94 172 95188 21897 46568805
Acute lymphocytic leukaemia 101.75 11.94 66 95294 2707 46587995
Rash 101.69 11.94 380 94980 356132 46234570
Swelling 100.84 11.94 65 95295 124446 46466256
Urticaria 100.41 11.94 58 95302 117834 46472868
Acute lymphocytic leukaemia recurrent 100.10 11.94 59 95301 2036 46588666
Metastases to central nervous system 98.33 11.94 118 95242 11103 46579599
Therapeutic product effect decreased 98.03 11.94 24 95336 82577 46508125
Synovitis 97.66 11.94 7 95353 61068 46529634
Pulmonary toxicity 97.24 11.94 79 95281 4614 46586088
Metastases to lymph nodes 95.92 11.94 91 95269 6540 46584162
Therapy partial responder 95.29 11.94 78 95282 4604 46586098
Arthropathy 94.13 11.94 28 95332 84672 46506030
Multiple organ dysfunction syndrome 93.92 11.94 275 95085 51435 46539267
Malaise 93.82 11.94 354 95006 330878 46259824
Injection site erythema 93.60 11.94 19 95341 74408 46516294
Depression 89.90 11.94 130 95230 169974 46420728
Drug intolerance 89.49 11.94 101 95259 146948 46443754
Asthma 88.55 11.94 38 95322 91504 46499198
Polyneuropathy 88.49 11.94 114 95246 11530 46579172
Contusion 88.39 11.94 34 95326 87453 46503249
Small intestinal obstruction 88.14 11.94 135 95225 16037 46574665
Blood pressure increased 87.37 11.94 78 95282 126588 46464114
Arthritis 86.94 11.94 25 95335 77291 46513411
Hospitalisation 86.66 11.94 13 95347 63372 46527330
Breast cancer recurrent 85.63 11.94 68 95292 3843 46586859
Bronchitis 82.22 11.94 58 95302 105921 46484781
Lymphopenia 78.24 11.94 124 95236 15169 46575533
Gene mutation 78.12 11.94 40 95320 1040 46589662
Metastasis 77.77 11.94 67 95293 4245 46586457
Gait disturbance 77.74 11.94 110 95250 145153 46445549
Ileus 77.49 11.94 118 95242 13946 46576756
Glossodynia 77.45 11.94 3 95357 44370 46546332
Myeloid leukaemia 76.94 11.94 28 95332 303 46590399
Tremor 76.45 11.94 74 95286 115565 46475137
Neoplasm recurrence 76.25 11.94 52 95308 2321 46588381
Leukaemia 75.83 11.94 59 95301 3236 46587466
Bacteraemia 75.36 11.94 117 95243 14062 46576640
Epstein-Barr virus infection 74.14 11.94 80 95280 6704 46583998
Drug interaction 72.89 11.94 195 95165 202899 46387803
Neutrophil count abnormal 72.41 11.94 51 95309 2399 46588303
Haemophagocytic lymphohistiocytosis 71.91 11.94 87 95273 8255 46582447
Stress 71.80 11.94 10 95350 51541 46539161
Bone marrow disorder 71.49 11.94 45 95315 1751 46588951
Drug resistance 70.49 11.94 127 95233 17241 46573461
Refractory anaemia with an excess of blasts 69.50 11.94 28 95332 407 46590295
Metastases to breast 69.41 11.94 25 95335 262 46590440
Pericardial effusion 68.19 11.94 157 95203 25386 46565316
Neutropenic infection 67.73 11.94 37 95323 1101 46589601
Stem cell transplant 67.18 11.94 43 95317 1723 46588979
Condition aggravated 66.03 11.94 267 95093 244785 46345917
Embolism 65.74 11.94 77 95283 7061 46583641
Lymphadenopathy 65.56 11.94 183 95177 33305 46557397
Injection site pruritus 65.17 11.94 4 95356 39739 46550963
Acute myelomonocytic leukaemia 64.75 11.94 22 95338 191 46590511
Pneumatosis intestinalis 64.18 11.94 44 95316 1981 46588721
Suicide attempt 63.35 11.94 17 95343 55019 46535683
Systemic candida 63.13 11.94 49 95311 2678 46588024
Osteoarthritis 62.82 11.94 24 95336 62001 46528701
Cataract 62.81 11.94 9 95351 45406 46545296
Infection 62.50 11.94 477 94883 133115 46457587
Extravasation 62.45 11.94 44 95316 2071 46588631
Cerebrovascular accident 60.79 11.94 70 95290 100969 46489733
Injection site swelling 60.69 11.94 6 95354 40321 46550381
Abdominal pain upper 60.46 11.94 129 95231 145176 46445526
Acquired gene mutation 60.13 11.94 28 95332 588 46590114
Recurrent cancer 60.00 11.94 40 95320 1719 46588983
Gastrointestinal toxicity 59.92 11.94 58 95302 4273 46586429
Smooth muscle cell neoplasm 59.37 11.94 27 95333 536 46590166
Invasive ductal breast carcinoma 59.26 11.94 68 95292 6100 46584602
Memory impairment 59.09 11.94 43 95317 77294 46513408
Ventricular hypokinesia 59.05 11.94 56 95304 4022 46586680
Metastases to peritoneum 57.89 11.94 46 95314 2602 46588100
Injection site bruising 57.21 11.94 4 95356 35632 46555070
Injection site reaction 56.57 11.94 14 95346 47835 46542867
Gastrooesophageal reflux disease 55.94 11.94 42 95318 74302 46516400
Injury 55.85 11.94 11 95349 44016 46546686
Cystitis haemorrhagic 55.78 11.94 51 95309 3496 46587206
Capillary leak syndrome 54.94 11.94 39 95321 1858 46588844
Bronchopulmonary aspergillosis 54.79 11.94 72 95288 7424 46583278
Encephalopathy 54.75 11.94 172 95188 33417 46557285
Suicidal ideation 53.57 11.94 24 95336 56358 46534344
Metastases to skin 53.49 11.94 34 95326 1346 46589356
Loss of personal independence in daily activities 53.31 11.94 25 95335 57158 46533544
Toxic cardiomyopathy 53.10 11.94 17 95343 120 46590582
Blood glucose increased 52.51 11.94 42 95318 71971 46518731
Palpitations 52.08 11.94 71 95289 95188 46495514
Balance disorder 51.78 11.94 34 95326 64487 46526215
Venoocclusive disease 51.60 11.94 38 95322 1918 46588784
Computerised tomogram thorax abnormal 51.43 11.94 33 95327 1328 46589374
Inappropriate schedule of product administration 51.17 11.94 35 95325 64978 46525724
Ileus paralytic 50.82 11.94 53 95307 4270 46586432
Confusional state 49.07 11.94 165 95195 159727 46430975
Wheezing 48.75 11.94 24 95336 53362 46537340
Lung infiltration 48.68 11.94 96 95264 13947 46576755
Respiratory failure 48.57 11.94 346 95014 94470 46496232
White blood cell count abnormal 48.33 11.94 56 95304 5076 46585626
5q minus syndrome 48.00 11.94 17 95343 169 46590533
Premature baby 47.98 11.94 111 95249 18001 46572701
Intestinal perforation 47.46 11.94 82 95278 10769 46579933
Hypogammaglobulinaemia 47.34 11.94 57 95303 5381 46585321
Hypoglycaemia 47.31 11.94 26 95334 54323 46536379
Device related infection 47.26 11.94 121 95239 20920 46569782
Nephrolithiasis 47.01 11.94 6 95354 33045 46557657
Philadelphia chromosome positive 46.93 11.94 19 95341 280 46590422
Loss of consciousness 46.78 11.94 94 95266 108144 46482558
Lymphoma transformation 46.68 11.94 16 95344 143 46590559
General physical health deterioration 46.34 11.94 399 94961 115370 46475332
Premature labour 46.33 11.94 83 95277 11216 46579486
Hepatic failure 46.33 11.94 162 95198 33254 46557448
Varicella zoster virus infection 45.53 11.94 38 95322 2305 46588397
B-cell lymphoma 45.36 11.94 44 95316 3250 46587452
Blood cholesterol increased 44.85 11.94 13 95347 40000 46550702
Wound 44.28 11.94 16 95344 42786 46547916
Surgery 44.06 11.94 4 95356 28781 46561921
Pneumocystis jirovecii infection 43.88 11.94 29 95331 1228 46589474
Nasal congestion 43.38 11.94 22 95338 48091 46542611
Clostridium bacteraemia 43.33 11.94 16 95344 181 46590521
Nephropathy toxic 43.14 11.94 64 95296 7390 46583312
Vision blurred 42.97 11.94 60 95300 79648 46511054
Incorrect dose administered 42.32 11.94 20 95340 45530 46545172
Clonal evolution 42.00 11.94 12 95348 54 46590648
Peripheral motor neuropathy 41.95 11.94 30 95330 1446 46589256
Unevaluable event 41.80 11.94 21 95339 46154 46544548
T-cell lymphoma 41.78 11.94 22 95338 607 46590095
Cardiomyopathy acute 41.75 11.94 16 95344 202 46590500
Plasmacytoma 41.68 11.94 37 95323 2440 46588262
Influenza 41.67 11.94 74 95286 89196 46501506
Cutaneous calcification 41.07 11.94 13 95347 88 46590614
Pulmonary embolism 40.75 11.94 369 94991 108216 46482486
Myelopathy 40.73 11.94 37 95323 2515 46588187
Plasma cell leukaemia 40.38 11.94 27 95333 1166 46589536
Alveolar soft part sarcoma 40.33 11.94 13 95347 94 46590608
Blood lactate dehydrogenase increased 40.09 11.94 112 95248 20388 46570314
Heart rate decreased 40.08 11.94 8 95352 31715 46558987
Enterococcal bacteraemia 39.65 11.94 27 95333 1202 46589500
Gastrosplenic fistula 39.54 11.94 11 95349 44 46590658
Migraine 39.48 11.94 51 95309 69975 46520727
Irritability 39.41 11.94 6 95354 28940 46561762
Neck pain 39.39 11.94 33 95327 55273 46535429
Hepatic enzyme increased 38.90 11.94 67 95293 81720 46508982
Heart rate abnormal 38.88 11.94 41 95319 3346 46587356
Urinary tract infection 38.71 11.94 277 95083 219989 46370713
Myocardial infarction 38.56 11.94 89 95271 97439 46493263
Gastrointestinal fungal infection 38.44 11.94 16 95344 254 46590448
Hyperhidrosis 38.21 11.94 78 95282 89230 46501472
Visual impairment 38.19 11.94 48 95312 66641 46524061
Fluid retention 38.19 11.94 29 95331 51017 46539685
Lymphadenitis 38.15 11.94 36 95324 2569 46588133
Atelectasis 38.08 11.94 104 95256 18686 46572016
Primary cardiac lymphoma 37.91 11.94 10 95350 31 46590671
Amnesia 37.58 11.94 19 95341 41612 46549090
Metastases to pleura 37.57 11.94 25 95335 1071 46589631
Perineal infection 37.37 11.94 13 95347 122 46590580
Breast cancer 36.69 11.94 187 95173 45331 46545371
Salivary gland cancer 36.55 11.94 13 95347 131 46590571
Agranulocytosis 36.51 11.94 114 95246 22071 46568631
Multiple sclerosis 36.50 11.94 4 95356 24787 46565915
Haematoma 36.38 11.94 10 95350 31862 46558840
Humoral immune defect 36.31 11.94 11 95349 63 46590639
Squamous cell carcinoma of the oral cavity 36.21 11.94 16 95344 296 46590406
Adverse drug reaction 36.10 11.94 23 95337 44339 46546363
Joint stiffness 36.05 11.94 6 95354 27102 46563600
T-cell type acute leukaemia 36.02 11.94 11 95349 65 46590637
Hypertriglyceridaemia 35.96 11.94 51 95309 5653 46585049
Musculoskeletal pain 35.64 11.94 55 95305 70073 46520629
Acute hepatitis B 35.58 11.94 16 95344 309 46590393
Limb discomfort 35.31 11.94 3 95357 22773 46567929
Haemoglobin abnormal 35.18 11.94 44 95316 4319 46586383
Rhabdomyolysis 35.12 11.94 21 95339 41888 46548814
Perineal necrosis 35.04 11.94 12 95348 107 46590595
Secondary immunodeficiency 35.01 11.94 23 95337 964 46589738
Synovial sarcoma 34.82 11.94 10 95350 46 46590656
Chronic obstructive pulmonary disease 34.58 11.94 40 95320 57593 46533109
Central nervous system lymphoma 34.52 11.94 25 95335 1229 46589473
Emotional distress 34.38 11.94 10 95350 30697 46560005
Acute leukaemia 34.36 11.94 24 95336 1114 46589588
Infection reactivation 34.33 11.94 21 95339 776 46589926
Mobility decreased 34.30 11.94 44 95316 60550 46530152
Angioedema 33.98 11.94 19 95341 39323 46551379
Blood pressure fluctuation 33.93 11.94 10 95350 30438 46560264
Mesenteric abscess 33.84 11.94 11 95349 82 46590620
Traumatic lung injury 33.77 11.94 26 95334 1404 46589298
Ovarian epithelial cancer recurrent 33.50 11.94 8 95352 14 46590688
Osteomyelitis bacterial 33.44 11.94 13 95347 171 46590531
International normalised ratio increased 33.36 11.94 28 95332 46855 46543847
Myasthenia gravis crisis 33.23 11.94 16 95344 363 46590339
Respiratory syncytial virus infection 33.13 11.94 45 95315 4790 46585912
Enterococcal sepsis 33.04 11.94 25 95335 1315 46589387
Carbohydrate antigen 125 increased 32.83 11.94 32 95328 2378 46588324
Thrombotic microangiopathy 32.77 11.94 60 95300 8246 46582456
Respiratory arrest 32.74 11.94 14 95346 33802 46556900
Product quality issue 32.59 11.94 16 95344 35632 46555070
Disseminated intravascular coagulation 32.52 11.94 99 95261 18906 46571796
Hepatitis E 32.52 11.94 24 95336 1215 46589487
Cardiogenic shock 32.52 11.94 90 95270 16294 46574408
Drug reaction with eosinophilia and systemic symptoms 32.39 11.94 10 95350 29538 46561164
JC virus infection 32.39 11.94 27 95333 1635 46589067
Mucosal toxicity 32.26 11.94 15 95345 314 46590388
Swollen tongue 31.85 11.94 10 95350 29222 46561480
Periorbital cellulitis 31.83 11.94 17 95343 483 46590219
Hallucination 31.81 11.94 33 95327 49918 46540784
Large intestinal ulcer perforation 31.68 11.94 10 95350 67 46590635
Exposure during pregnancy 31.53 11.94 349 95011 107863 46482839
Hepatic infarction 31.48 11.94 18 95342 586 46590116
Flatulence 31.25 11.94 10 95350 28868 46561834
Hypoxia 31.24 11.94 197 95163 51641 46539061
Cytomegalovirus viraemia 31.17 11.94 42 95318 4436 46586266
Maternal exposure before pregnancy 31.15 11.94 42 95318 4439 46586263
Flagellate dermatitis 31.14 11.94 12 95348 154 46590548
Escherichia bacteraemia 30.95 11.94 33 95327 2728 46587974
Body dysmorphic disorder 30.93 11.94 12 95348 157 46590545
Mantle cell lymphoma recurrent 30.74 11.94 11 95349 113 46590589
Discomfort 30.67 11.94 30 95330 46640 46544062
Nephroblastoma 30.57 11.94 11 95349 115 46590587
Pneumonia fungal 30.47 11.94 40 95320 4120 46586582
Chest pain 30.36 11.94 223 95137 176101 46414601
Therapeutic response delayed 30.34 11.94 17 95343 532 46590170
Peripheral T-cell lymphoma unspecified 30.16 11.94 13 95347 226 46590476
Localised infection 30.07 11.94 6 95354 23795 46566907
Toxic neuropathy 29.98 11.94 15 95345 371 46590331
Alveolitis 29.88 11.94 31 95329 2482 46588220
Acne 29.87 11.94 3 95357 19916 46570786
Metastases to spine 29.84 11.94 32 95328 2662 46588040
Malignant transformation 29.77 11.94 14 95346 301 46590401
Coronary artery disease 29.59 11.94 16 95344 33736 46556966
Abnormal behaviour 29.52 11.94 4 95356 21054 46569648
Fatigue 29.50 11.94 984 94376 607713 45982989
Foot fracture 29.23 11.94 3 95357 19579 46571123
Nail pigmentation 29.21 11.94 12 95348 184 46590518
Heart rate increased 28.96 11.94 69 95291 74722 46515980
Metastases to meninges 28.93 11.94 27 95333 1900 46588802
Lip swelling 28.93 11.94 8 95352 25387 46565315
Abdominal compartment syndrome 28.91 11.94 17 95343 584 46590118
Cardiac cirrhosis 28.77 11.94 11 95349 138 46590564
Epstein-Barr virus associated lymphoproliferative disorder 28.76 11.94 24 95336 1455 46589247
Abortion spontaneous 28.74 11.94 28 95332 43618 46547084
Amenorrhoea 28.67 11.94 59 95301 8836 46581866
Leukoencephalopathy 28.55 11.94 38 95322 3966 46586736
Nodular regenerative hyperplasia 28.54 11.94 13 95347 259 46590443
Chemotherapy 28.52 11.94 23 95337 1329 46589373
Lymphatic disorder 28.48 11.94 14 95346 333 46590369
Limb injury 28.46 11.94 3 95357 19171 46571531
Nasal abscess 28.28 11.94 11 95349 145 46590557
Infusion site streaking 28.25 11.94 14 95346 339 46590363
Aggression 28.18 11.94 6 95354 22738 46567964
Liver function test abnormal 28.17 11.94 32 95328 46455 46544247
Bone lesion 28.05 11.94 42 95318 4889 46585813
Cytogenetic abnormality 27.95 11.94 16 95344 522 46590180
Thyroid dermatopathy 27.78 11.94 7 95353 17 46590685
Oesophageal candidiasis 27.76 11.94 43 95317 5157 46585545
Blood pressure systolic increased 27.74 11.94 12 95348 28775 46561927
Colitis 27.74 11.94 150 95210 37197 46553505
Diabetes mellitus 27.67 11.94 37 95323 50028 46540674
Pyomyositis 27.66 11.94 14 95346 355 46590347
Unintentional medical device removal 27.66 11.94 40 95320 4513 46586189
Intestinal obstruction 27.58 11.94 116 95244 25959 46564743
Sleep disorder 27.51 11.94 33 95327 46762 46543940
Leiomyosarcoma metastatic 27.50 11.94 7 95353 18 46590684
Platelet count abnormal 27.37 11.94 31 95329 2741 46587961
Heart rate irregular 27.37 11.94 3 95357 18588 46572114
Leukoerythroblastosis 27.26 11.94 12 95348 220 46590482
Intertrigo 26.93 11.94 14 95346 376 46590326
Mucormycosis 26.76 11.94 28 95332 2264 46588438
Listeria sepsis 26.76 11.94 16 95344 567 46590135
Ear infection 26.68 11.94 7 95353 23006 46567696
Swelling face 26.59 11.94 42 95318 53017 46537685
Treatment failure 26.57 11.94 99 95261 92988 46497714
Colony stimulating factor therapy 26.53 11.94 13 95347 307 46590395
Hypoaesthesia 26.33 11.94 139 95221 118730 46471972
Bicytopenia 26.31 11.94 24 95336 1640 46589062
Osteosarcoma metastatic 26.23 11.94 7 95353 23 46590679
Pseudomonal sepsis 26.19 11.94 26 95334 1976 46588726
Rash pruritic 26.18 11.94 31 95329 44184 46546518
Clonal haematopoiesis 26.11 11.94 6 95354 8 46590694
Tongue neoplasm malignant stage unspecified 26.07 11.94 18 95342 820 46589882
Gastric disorder 25.94 11.94 11 95349 26694 46564008
Pulmonary alveolar haemorrhage 25.92 11.94 37 95323 4125 46586577
Leukaemic lymphoma 25.91 11.94 9 95351 84 46590618
Cardio-respiratory arrest 25.85 11.94 52 95308 59817 46530885
B-cell lymphoma refractory 25.82 11.94 9 95351 85 46590617
Agitation 25.79 11.94 46 95314 55369 46535333
Mitral valve incompetence 25.78 11.94 91 95269 18761 46571941
Weight decreased 25.70 11.94 291 95069 210558 46380144
Non-cirrhotic portal hypertension 25.36 11.94 9 95351 90 46590612
Femur fracture 25.22 11.94 23 95337 36974 46553728
Dry mouth 25.20 11.94 46 95314 54880 46535822
Bursitis 25.07 11.94 5 95355 19837 46570865
Blood lactate dehydrogenase abnormal 24.85 11.94 12 95348 274 46590428
Metastases to soft tissue 24.72 11.94 10 95350 147 46590555
Necrotising colitis 24.65 11.94 15 95345 549 46590153
Epstein-Barr virus associated lymphoma 24.62 11.94 12 95348 280 46590422
Osteoporosis 24.55 11.94 28 95332 40580 46550122
Cardiac dysfunction 24.55 11.94 22 95338 1469 46589233
Gastric stenosis 24.45 11.94 8 95352 61 46590641
Angioimmunoblastic T-cell lymphoma 24.36 11.94 9 95351 102 46590600
Vena cava thrombosis 24.34 11.94 26 95334 2153 46588549
Therapy cessation 24.27 11.94 12 95348 26617 46564085
Road traffic accident 24.26 11.94 9 95351 23682 46567020
Large intestine perforation 24.10 11.94 50 95310 7530 46583172
Influenza like illness 24.01 11.94 51 95309 57519 46533183
Ovarian cancer metastatic 23.96 11.94 17 95343 809 46589893
Eosinophilia 23.96 11.94 5 95355 19212 46571490
Deafness bilateral 23.76 11.94 20 95340 1227 46589475
Small intestinal perforation 23.75 11.94 20 95340 1228 46589474
Intussusception 23.70 11.94 14 95346 485 46590217
C-reactive protein abnormal 23.67 11.94 7 95353 21263 46569439
Klebsiella infection 23.64 11.94 46 95314 6616 46584086
Proteinuria 23.59 11.94 81 95279 16472 46574230
Left atrial enlargement 23.58 11.94 11 95349 232 46590470
Necrotising gastritis 23.58 11.94 7 95353 37 46590665
Eye swelling 23.53 11.94 6 95354 20097 46570605
Oligohydramnios 23.51 11.94 41 95319 5424 46585278
Crying 23.45 11.94 7 95353 21134 46569568
Treatment noncompliance 23.40 11.94 16 95344 29715 46560987
Pulse waveform abnormal 23.29 11.94 8 95352 72 46590630
Plasmablastic lymphoma 23.28 11.94 11 95349 239 46590463
Hydrothorax 23.28 11.94 15 95345 608 46590094
Ankle brachial index decreased 23.19 11.94 8 95352 73 46590629
Plasma cell myeloma 23.16 11.94 163 95197 44315 46546387
Angiosarcoma 23.16 11.94 11 95349 242 46590460
Cardiac failure acute 23.06 11.94 51 95309 8027 46582675
Cerebellar stroke 23.03 11.94 10 95350 177 46590525
Dry eye 22.97 11.94 17 95343 30305 46560397
Cardiac failure chronic 22.94 11.94 32 95328 3492 46587210
Acute respiratory distress syndrome 22.77 11.94 97 95263 21825 46568877
Anastomotic leak 22.74 11.94 13 95347 423 46590279
Carotid intima-media thickness increased 22.73 11.94 8 95352 78 46590624
Blood pressure decreased 22.72 11.94 52 95308 57107 46533595
Gait inability 22.70 11.94 23 95337 35180 46555522
Klebsiella bacteraemia 22.70 11.94 19 95341 1157 46589545
Primary immunodeficiency syndrome 22.69 11.94 7 95353 43 46590659
Ventricular internal diameter abnormal 22.69 11.94 7 95353 43 46590659
Bacterial sepsis 22.64 11.94 32 95328 3535 46587167
Tumour necrosis 22.60 11.94 16 95344 759 46589943
Dysplasia 22.55 11.94 15 95345 642 46590060
Venoocclusive liver disease 22.48 11.94 35 95325 4216 46586486
Chylothorax 22.13 11.94 11 95349 268 46590434
Joint ankylosis 22.12 11.94 14 95346 550 46590152
Enterococcal infection 22.11 11.94 46 95314 6941 46583761
Lactic acidosis 22.04 11.94 22 95338 33887 46556815
Fungal oesophagitis 22.03 11.94 14 95346 554 46590148
Bradycardia 22.01 11.94 66 95294 66232 46524470
Serotonin syndrome 21.94 11.94 11 95349 24209 46566493
Drug clearance decreased 21.93 11.94 18 95342 1066 46589636
Chronic myeloid leukaemia 21.78 11.94 26 95334 2432 46588270
Acute biphenotypic leukaemia 21.67 11.94 7 95353 51 46590651
Product prescribing error 21.59 11.94 7 95353 20040 46570662
Nightmare 21.36 11.94 4 95356 16594 46574108
Red blood cell sedimentation rate increased 21.34 11.94 10 95350 22879 46567823
Myeloproliferative neoplasm 21.31 11.94 13 95347 478 46590224
Sarcoidosis 21.28 11.94 38 95322 5121 46585581
Dysstasia 21.21 11.94 5 95355 17663 46573039
Mediastinitis 21.18 11.94 10 95350 217 46590485
Leukaemia cutis 21.17 11.94 8 95352 97 46590605
Device dislocation 21.15 11.94 9 95351 21793 46568909
Subdural hygroma 20.97 11.94 10 95350 222 46590480
BRCA2 gene mutation 20.89 11.94 7 95353 58 46590644
Throat irritation 20.88 11.94 17 95343 28884 46561818
Cerebral venous sinus thrombosis 20.79 11.94 22 95338 1803 46588899
Sinus polyp 20.77 11.94 11 95349 307 46590395
Administration site extravasation 20.70 11.94 14 95346 616 46590086
Chronic myelomonocytic leukaemia 20.58 11.94 11 95349 313 46590389
Intervertebral disc protrusion 20.48 11.94 8 95352 20397 46570305
Invasive lobular breast carcinoma 20.46 11.94 14 95346 628 46590074
Radiation necrosis 20.42 11.94 11 95349 318 46590384
Lower respiratory tract infection 20.40 11.94 52 95308 55037 46535665
Combined immunodeficiency 20.39 11.94 8 95352 108 46590594
Pneumothorax 20.34 11.94 71 95289 14558 46576144
Amputation stump pain 20.32 11.94 6 95354 31 46590671
Bone marrow infiltration 20.31 11.94 12 95348 416 46590286
Pneumonitis chemical 20.29 11.94 9 95351 168 46590534
Nervousness 20.26 11.94 17 95343 28458 46562244
Aspergillus infection 20.23 11.94 44 95316 6846 46583856
Glaucoma 20.14 11.94 4 95356 15917 46574785
Peripheral sensorimotor neuropathy 20.11 11.94 18 95342 1200 46589502
Adult T-cell lymphoma/leukaemia 20.02 11.94 11 95349 331 46590371
Injection site rash 19.95 11.94 4 95356 15809 46574893
Quadriplegia 19.89 11.94 21 95339 1716 46588986
Malignant ascites 19.77 11.94 16 95344 929 46589773
Inflammation 19.69 11.94 44 95316 48737 46541965
Faeces discoloured 19.67 11.94 5 95355 16782 46573920
Drug dependence 19.65 11.94 8 95352 19893 46570809
Pseudocirrhosis 19.59 11.94 14 95346 674 46590028
Blood magnesium decreased 19.50 11.94 58 95302 10934 46579768
Hyperkalaemia 19.46 11.94 47 95313 50662 46540040
Colitis ulcerative 19.44 11.94 6 95354 17726 46572976
Haematochezia 19.43 11.94 29 95331 37464 46553238
Malignant neoplasm of pleura 19.38 11.94 7 95353 74 46590628
Metastases to the mediastinum 19.34 11.94 12 95348 455 46590247
B precursor type acute leukaemia 19.33 11.94 9 95351 189 46590513
Rhinovirus infection 19.31 11.94 30 95330 3606 46587096
Pulmonary vein stenosis 19.30 11.94 7 95353 75 46590627
Angiocentric lymphoma 19.29 11.94 12 95348 457 46590245
Toxic encephalopathy 19.26 11.94 36 95324 5026 46585676
Geotrichum infection 19.22 11.94 12 95348 460 46590242
Fungaemia 19.21 11.94 22 95338 1969 46588733
Blast cells present 19.19 11.94 11 95349 360 46590342
Metastases to chest wall 19.18 11.94 12 95348 462 46590240
Subileus 19.15 11.94 27 95333 2976 46587726
Mantle cell lymphoma 19.11 11.94 13 95347 578 46590124
Tooth disorder 19.07 11.94 12 95348 23291 46567411
Endometrial cancer 19.02 11.94 25 95335 2578 46588124
Leukaemia recurrent 19.00 11.94 18 95342 1291 46589411
Invasive breast carcinoma 18.99 11.94 12 95348 470 46590232
Mitral valve disease 18.95 11.94 23 95337 2189 46588513
Transaminases 18.89 11.94 7 95353 80 46590622
Lip and/or oral cavity cancer 18.89 11.94 10 95350 279 46590423
Eczema 18.88 11.94 9 95351 20391 46570311
Portal hypertension 18.87 11.94 29 95331 3454 46587248
Subclavian vein thrombosis 18.84 11.94 21 95339 1825 46588877
Refractory cytopenia with multilineage dysplasia 18.83 11.94 8 95352 134 46590568
Cytomegalovirus chorioretinitis 18.66 11.94 19 95341 1488 46589214
Jejunal stenosis 18.66 11.94 6 95354 43 46590659
Venous thrombosis limb 18.64 11.94 26 95334 2837 46587865
Lymphoma 18.59 11.94 53 95307 9760 46580942
Hypoalbuminaemia 18.51 11.94 54 95306 10073 46580629
Restlessness 18.46 11.94 15 95345 25509 46565193
Clostridium difficile colitis 18.43 11.94 81 95279 18472 46572230
Hypokalaemia 18.42 11.94 267 95093 87757 46502945
Chronic lymphocytic leukaemia 18.38 11.94 26 95334 2874 46587828
Laboratory test abnormal 18.38 11.94 12 95348 22835 46567867
Acute pulmonary oedema 18.36 11.94 46 95314 7845 46582857
Opsoclonus myoclonus 18.35 11.94 8 95352 143 46590559
Vulvovaginitis 18.35 11.94 10 95350 296 46590406
Eye pain 18.31 11.94 18 95342 27922 46562780
Sciatica 18.21 11.94 8 95352 19012 46571690
Blood stem cell transplant failure 18.15 11.94 8 95352 147 46590555
Mucoepidermoid carcinoma 18.09 11.94 6 95354 48 46590654
Peritonitis viral 18.09 11.94 6 95354 48 46590654
Depressed mood 18.03 11.94 25 95335 33294 46557408
Neonatal lupus erythematosus 18.02 11.94 4 95356 4 46590698
Increased liver stiffness 18.02 11.94 4 95356 4 46590698
Oral fungal infection 18.00 11.94 24 95336 2510 46588192
Metastases to abdominal cavity 17.99 11.94 11 95349 406 46590296
Movement disorder 17.94 11.94 6 95354 16843 46573859
Desmoplastic small round cell tumour 17.91 11.94 8 95352 152 46590550
Neuroblastoma 17.87 11.94 6 95354 50 46590652
Paranasal sinus mucosal hypertrophy 17.78 11.94 5 95355 21 46590681
Urethritis 17.75 11.94 9 95351 229 46590473
Trichodysplasia spinulosa 17.71 11.94 11 95349 418 46590284
Seasonal allergy 17.62 11.94 3 95357 13331 46577371
Epstein Barr virus positive mucocutaneous ulcer 17.61 11.94 9 95351 233 46590469
Central nervous system enteroviral infection 17.59 11.94 5 95355 22 46590680
Basal cell carcinoma 17.54 11.94 10 95350 20477 46570225
Sinus disorder 17.46 11.94 6 95354 16557 46574145
Osteolysis 17.43 11.94 24 95336 2588 46588114
Pericarditis 17.38 11.94 14 95346 23913 46566789
Chronic hepatitis 17.34 11.94 14 95346 810 46589892
Rhabdomyosarcoma 17.24 11.94 7 95353 104 46590598
Head injury 17.17 11.94 15 95345 24621 46566081
Transient ischaemic attack 17.13 11.94 28 95332 34875 46555827
Therapy non-responder 17.06 11.94 143 95217 41009 46549693
Granulocytopenia 17.02 11.94 35 95325 5238 46585464
Poor quality sleep 17.01 11.94 5 95355 15248 46575454
Renal tubular disorder 16.98 11.94 23 95337 2442 46588260
Oedema peripheral 16.95 11.94 227 95133 159479 46431223
Herpes zoster meningoencephalitis 16.91 11.94 9 95351 254 46590448
Accidental overdose 16.89 11.94 10 95350 20056 46570646
Rhinorrhoea 16.88 11.94 46 95314 47619 46543083
Pleural neoplasm 16.88 11.94 7 95353 110 46590592
Disorientation 16.86 11.94 31 95329 36887 46553815
Radiation skin injury 16.86 11.94 14 95346 843 46589859
Urinary retention 16.83 11.94 17 95343 26044 46564658
Depressed level of consciousness 16.78 11.94 46 95314 47523 46543179
Clostridium difficile infection 16.77 11.94 98 95262 25005 46565697
Duodenal stenosis 16.75 11.94 12 95348 580 46590122
Right ventricular failure 16.67 11.94 6 95354 16087 46574615
Impaired healing 16.65 11.94 31 95329 36712 46553990
Onycholysis 16.61 11.94 16 95344 1172 46589530
Inflammatory myofibroblastic tumour 16.60 11.94 5 95355 28 46590674
Listeria encephalitis 16.52 11.94 8 95352 184 46590518
Hepatocellular injury 16.44 11.94 110 95250 29412 46561290
Tumour ulceration 16.43 11.94 7 95353 118 46590584
Leukoplakia oral 16.43 11.94 7 95353 118 46590584
Metastases to stomach 16.43 11.94 7 95353 118 46590584
Primary mediastinal large B-cell lymphoma recurrent 16.40 11.94 6 95354 66 46590636
Hyperpyrexia 16.37 11.94 24 95336 2742 46587960
Enterocutaneous fistula 16.36 11.94 16 95344 1194 46589508
Impaired work ability 16.36 11.94 3 95357 12633 46578069
Deep vein thrombosis 16.30 11.94 241 95119 79532 46511170
Dermatitis bullous 16.18 11.94 43 95317 7600 46583102
Kidney infection 16.17 11.94 7 95353 16782 46573920
Ototoxicity 16.09 11.94 15 95345 1054 46589648
Ventricular remodelling 16.09 11.94 4 95356 9 46590693
Lymph node pain 16.07 11.94 16 95344 1220 46589482
Hypoglossal nerve paresis 16.07 11.94 7 95353 125 46590577
Respiratory distress 16.05 11.94 116 95244 31800 46558902
Upper limb fracture 16.04 11.94 6 95354 15707 46574995
Metastases to pancreas 16.02 11.94 8 95352 197 46590505
Brain oedema 16.02 11.94 59 95301 12419 46578283
Eye irritation 15.89 11.94 7 95353 16607 46574095
Enterovirus test positive 15.87 11.94 7 95353 129 46590573
Acute lymphocytic leukaemia refractory 15.86 11.94 6 95354 73 46590629
Panic attack 15.79 11.94 11 95349 20231 46570471
Febrile infection 15.78 11.94 16 95344 1247 46589455
Jejunal ulcer perforation 15.78 11.94 5 95355 34 46590668
Gallbladder disorder 15.77 11.94 8 95352 17490 46573212
Diverticulitis 15.76 11.94 27 95333 33012 46557690
Irritable bowel syndrome 15.73 11.94 7 95353 16508 46574194
Human rhinovirus test positive 15.72 11.94 7 95353 132 46590570
Acute monocytic leukaemia 15.71 11.94 6 95354 75 46590627
Wernicke's encephalopathy 15.65 11.94 5 95355 35 46590667
Left ventricular dilatation 15.60 11.94 9 95351 298 46590404
Non-obstructive cardiomyopathy 15.59 11.94 3 95357 0 46590702
Staphylococcal sepsis 15.57 11.94 42 95318 7490 46583212
Orthopnoea 15.53 11.94 36 95324 5844 46584858
Metastatic neoplasm 15.51 11.94 27 95333 3566 46587136
Renal disorder 15.49 11.94 19 95341 26667 46564035
Fanconi syndrome 15.48 11.94 14 95346 946 46589756
VIth nerve paresis 15.43 11.94 6 95354 79 46590623
Lymphoproliferative disorder 15.41 11.94 23 95337 2669 46588033
Precursor T-lymphoblastic lymphoma/leukaemia 15.41 11.94 5 95355 37 46590665
Abdominal abscess 15.40 11.94 29 95331 4070 46586632
Rectal fissure 15.37 11.94 11 95349 531 46590171
Diabetes mellitus inadequate control 15.36 11.94 4 95356 13210 46577492
Tendonitis 15.35 11.94 5 95355 14272 46576430
Syphilis 15.34 11.94 7 95353 140 46590562
Prescribed underdose 15.31 11.94 3 95357 12050 46578652
Meningitis streptococcal 15.30 11.94 7 95353 141 46590561
Granulomatous pneumonitis 15.30 11.94 5 95355 38 46590664
Procedural pain 15.30 11.94 4 95356 13175 46577527
Cytology abnormal 15.26 11.94 4 95356 12 46590690
Systolic dysfunction 15.25 11.94 16 95344 1298 46589404
Gastrointestinal haemorrhage 15.22 11.94 94 95266 77279 46513423
Pulmonary artery stenosis 15.21 11.94 7 95353 143 46590559
Pneumonia influenzal 15.11 11.94 17 95343 1492 46589210
Joint range of motion decreased 15.06 11.94 6 95354 15118 46575584
Salmonella sepsis 15.05 11.94 8 95352 225 46590477
Ovarian cyst 15.03 11.94 5 95355 14082 46576620
Acral peeling skin syndrome 15.02 11.94 4 95356 13 46590689
Acute erythroid leukaemia 15.02 11.94 4 95356 13 46590689
Dysarthria 14.99 11.94 34 95326 37464 46553238
Product administration error 14.95 11.94 11 95349 19670 46571032
Cytomegalovirus infection 14.94 11.94 75 95285 18069 46572633
Osteopenia 14.92 11.94 8 95352 16953 46573749
Cardiac tamponade 14.90 11.94 30 95330 4424 46586278
Performance status decreased 14.86 11.94 25 95335 3212 46587490
Vulvovaginal inflammation 14.83 11.94 11 95349 561 46590141
Oral candidiasis 14.81 11.94 73 95287 17459 46573243
Hyperbilirubinaemia 14.81 11.94 51 95309 10387 46580315
Blood creatine phosphokinase increased 14.80 11.94 21 95339 27703 46562999
Hepatic calcification 14.80 11.94 4 95356 14 46590688
Acute hepatitis C 14.78 11.94 6 95354 89 46590613
Cutaneous T-cell lymphoma 14.76 11.94 16 95344 1347 46589355
Dementia 14.74 11.94 6 95354 14924 46575778
Vessel puncture site bruise 14.73 11.94 9 95351 332 46590370
Cholelithiasis 14.72 11.94 36 95324 38645 46552057
Pharyngeal inflammation 14.72 11.94 11 95349 568 46590134
Skin mass 14.69 11.94 33 95327 5247 46585455
Venous thrombosis 14.66 11.94 31 95329 4731 46585971
Liver function test increased 14.62 11.94 15 95345 22811 46567891
Metastases to retroperitoneum 14.61 11.94 7 95353 157 46590545
Sputum discoloured 14.60 11.94 4 95356 12774 46577928
Refractory cytopenia with unilineage dysplasia 14.58 11.94 11 95349 576 46590126
Sneezing 14.54 11.94 4 95356 12737 46577965
Metastases to ovary 14.53 11.94 9 95351 340 46590362
Pulmonary arterial hypertension 14.49 11.94 19 95341 25909 46564793
Beta 2 microglobulin decreased 14.38 11.94 4 95356 16 46590686
Candida infection 14.32 11.94 86 95274 22154 46568548
Wrist fracture 14.32 11.94 3 95357 11500 46579202
Hip fracture 14.29 11.94 20 95340 26536 46564166
Speech disorder 14.29 11.94 33 95327 36134 46554568
Lethargy 14.22 11.94 55 95305 51116 46539586
Liver abscess 14.21 11.94 22 95338 2637 46588065
Coma 14.19 11.94 66 95294 58283 46532419
Metastases to vagina 14.18 11.94 4 95356 17 46590685
Pulmonary haemorrhage 14.18 11.94 37 95323 6468 46584234
B-lymphocyte count abnormal 14.18 11.94 5 95355 49 46590653
Adrenocortical carcinoma 14.18 11.94 5 95355 49 46590653
Burning sensation 14.18 11.94 45 95315 44366 46546336
Radiation injury 14.17 11.94 10 95350 472 46590230
Pyloric stenosis 14.16 11.94 9 95351 356 46590346
Diabetic ketoacidosis 14.06 11.94 10 95350 18200 46572502
Hypersomnia 14.00 11.94 7 95353 15432 46575270
Anal injury 14 11.94 4 95356 18 46590684
Disturbance in attention 13.97 11.94 27 95333 31533 46559169
Diarrhoea 13.97 11.94 970 94390 558632 46032070
Iron deficiency anaemia 13.89 11.94 9 95351 17197 46573505
Orthostatic hypotension 13.85 11.94 18 95342 24640 46566062
Rash erythematous 13.85 11.94 31 95329 34319 46556383
Therapeutic product effect incomplete 13.84 11.94 98 95262 78055 46512647
Ocular hyperaemia 13.74 11.94 12 95348 19698 46571004
Lung adenocarcinoma 13.68 11.94 28 95332 4176 46586526
Dysgeusia 13.66 11.94 40 95320 40451 46550251
Malignant neoplasm of orbit 13.66 11.94 4 95356 20 46590682
Endocrine ophthalmopathy 13.65 11.94 8 95352 273 46590429
Intervertebral disc degeneration 13.63 11.94 5 95355 13247 46577455
Failure to thrive 13.61 11.94 37 95323 6627 46584075
Muscular weakness 13.56 11.94 121 95239 91723 46498979
Fibrous histiocytoma 13.52 11.94 10 95350 508 46590194
Chondrosarcoma metastatic 13.51 11.94 3 95357 3 46590699
Vaginal obstruction 13.51 11.94 3 95357 3 46590699
Hypertransaminasaemia 13.51 11.94 25 95335 3463 46587239
Abdominal distension 13.47 11.94 91 95269 73260 46517442
Vascular compression 13.43 11.94 6 95354 114 46590588
Enterocolitis 13.36 11.94 35 95325 6133 46584569
Ocular lymphoma 13.35 11.94 5 95355 59 46590643
Antithrombin III decreased 13.29 11.94 8 95352 287 46590415
Infusion related reaction 13.27 11.94 285 95075 100923 46489779
Cerebral haemangioma 13.24 11.94 6 95354 118 46590584
Metastases to thorax 13.23 11.94 7 95353 195 46590507
Paraparesis 13.21 11.94 18 95342 1921 46588781
Glycosylated haemoglobin increased 13.21 11.94 3 95357 10873 46579829
Granuloma 13.20 11.94 26 95334 3772 46586930
Osteonecrosis 13.20 11.94 94 95266 25650 46565052
Uterine leiomyosarcoma 13.19 11.94 4 95356 23 46590679
Artificial menopause 13.19 11.94 4 95356 23 46590679
Adenovirus infection 13.19 11.94 22 95338 2808 46587894
Fluid overload 13.17 11.94 22 95338 27163 46563539
Oesophagitis 13.11 11.94 59 95301 13592 46577110
Pneumonia cytomegaloviral 13.06 11.94 18 95342 1942 46588760
Low birth weight baby 12.99 11.94 32 95328 5402 46585300
Mental disorder 12.98 11.94 16 95344 22409 46568293
IIIrd nerve paralysis 12.97 11.94 11 95349 682 46590020
Mediastinal fibrosis 12.91 11.94 4 95356 25 46590677
Obliterative bronchiolitis 12.90 11.94 17 95343 1758 46588944
Malignant peritoneal neoplasm 12.89 11.94 11 95349 688 46590014
Respiratory tract congestion 12.82 11.94 5 95355 12759 46577943
Lymphadenopathy mediastinal 12.81 11.94 20 95340 2414 46588288
Corneal graft rejection 12.78 11.94 4 95356 26 46590676
Troponin increased 12.71 11.94 40 95320 7776 46582926
Triple negative breast cancer 12.67 11.94 6 95354 131 46590571
Lymphocytosis 12.67 11.94 19 95341 2215 46588487
Thrombophlebitis 12.65 11.94 28 95332 4409 46586293
Desmoid tumour 12.65 11.94 5 95355 69 46590633
Hormone receptor positive breast cancer 12.64 11.94 9 95351 431 46590271
Dysaesthesia 12.63 11.94 23 95337 3148 46587554
Vertigo 12.58 11.94 59 95301 51989 46538713
Ligament sprain 12.58 11.94 3 95357 10516 46580186
Product use issue 12.56 11.94 267 95093 94377 46496325
Rotator cuff syndrome 12.55 11.94 4 95356 11579 46579123
Adenoviral haemorrhagic cystitis 12.51 11.94 6 95354 135 46590567
Pulmonary fibrosis 12.50 11.94 77 95283 20015 46570687
Pleural disorder 12.49 11.94 10 95350 572 46590130
Pelvic fracture 12.48 11.94 4 95356 11535 46579167
Vomiting 12.47 11.94 1080 94280 451714 46138988
Diffuse large B-cell lymphoma stage IV 12.47 11.94 7 95353 220 46590482
Anaplastic large cell lymphoma T- and null-cell types 12.45 11.94 5 95355 72 46590630
Encephalitis viral 12.45 11.94 16 95344 1614 46589088
Pseudomonas infection 12.41 11.94 46 95314 9712 46580990
Cancer in remission 12.40 11.94 4 95356 29 46590673
Myocardial oedema 12.33 11.94 5 95355 74 46590628
Leukocytosis 12.32 11.94 86 95274 23312 46567390
Diffuse large B-cell lymphoma stage I 12.30 11.94 3 95357 6 46590696
Cerebellar mutism 12.30 11.94 3 95357 6 46590696
Head discomfort 12.29 11.94 3 95357 10348 46580354
Pleurodesis 12.28 11.94 4 95356 30 46590672
Bladder perforation 12.27 11.94 6 95354 141 46590561
Blood potassium increased 12.23 11.94 10 95350 16957 46573745
Thrombocytopenic purpura 12.21 11.94 14 95346 1254 46589448
Oropharyngeal pain 12.18 11.94 95 95265 74073 46516629
Product intolerance 12.17 11.94 4 95356 31 46590671
Coronary ostial stenosis 12.15 11.94 5 95355 77 46590625
Areflexia 12.13 11.94 22 95338 3001 46587701
Hypoacusis 12.10 11.94 15 95345 20954 46569748
Cardiac ventricular thrombosis 12.09 11.94 9 95351 462 46590240
Hepatotoxicity 12.06 11.94 90 95270 24919 46565783
Candida pneumonia 12.04 11.94 6 95354 147 46590555
Viral haemorrhagic cystitis 12.03 11.94 10 95350 603 46590099
Skin laceration 12.03 11.94 12 95348 18490 46572212
Tumour marker increased 12.02 11.94 24 95336 3517 46587185
Hepatitis C RNULL increased 12.01 11.94 6 95354 148 46590554
Rash macular 11.95 11.94 13 95347 19247 46571455

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3200.69 13.40 2383 70170 104310 29775615
Neutropenia 1178.02 13.40 1499 71054 127041 29752884
Product use in unapproved indication 918.49 13.40 1007 71546 72686 29807239
Off label use 758.87 13.40 1781 70772 247509 29632416
Hepatitis B 656.36 13.40 312 72241 5760 29874165
Mucosal inflammation 611.60 13.40 541 72012 29953 29849972
Second primary malignancy 542.27 13.40 278 72275 6078 29873847
Diffuse large B-cell lymphoma recurrent 493.05 13.40 187 72366 1905 29878020
Diffuse large B-cell lymphoma 458.15 13.40 267 72286 7574 29872351
Myelodysplastic syndrome 458.09 13.40 373 72180 18405 29861520
Acute myeloid leukaemia 439.93 13.40 358 72195 17648 29862277
Cardiotoxicity 438.23 13.40 214 72339 4200 29875725
Bone marrow failure 434.08 13.40 443 72110 29342 29850583
Haematotoxicity 384.18 13.40 219 72334 5951 29873974
Febrile bone marrow aplasia 334.15 13.40 221 72332 7876 29872049
Tumour lysis syndrome 322.75 13.40 260 72293 12625 29867300
Hepatitis B reactivation 320.56 13.40 151 72402 2726 29877199
Pneumocystis jirovecii pneumonia 302.37 13.40 283 72270 16837 29863088
Pancytopenia 299.63 13.40 646 71907 84406 29795519
Myelosuppression 269.06 13.40 186 72367 7136 29872789
Leukopenia 259.55 13.40 478 72075 55681 29824244
Progressive multifocal leukoencephalopathy 256.21 13.40 196 72357 8817 29871108
Thrombocytopenia 249.69 13.40 814 71739 136230 29743695
Disease progression 249.07 13.40 578 71975 79296 29800629
Neutrophil count decreased 217.43 13.40 378 72175 42076 29837849
Neutropenic sepsis 215.80 13.40 196 72357 11213 29868712
Cytomegalovirus chorioretinitis 211.52 13.40 119 72434 3149 29876776
Acquired gene mutation 207.60 13.40 85 72468 1076 29878849
Diffuse large B-cell lymphoma refractory 188.67 13.40 71 72482 706 29879219
Fall 187.19 13.40 104 72449 181768 29698157
Pyrexia 184.54 13.40 1281 71272 293208 29586717
Product dose omission issue 172.37 13.40 13 72540 91618 29788307
Neoplasm progression 171.63 13.40 215 72338 17808 29862117
Posterior reversible encephalopathy syndrome 159.62 13.40 147 72406 8560 29871365
B-cell lymphoma recurrent 157.01 13.40 59 72494 584 29879341
Malignant neoplasm progression 154.18 13.40 454 72099 71833 29808092
Therapy partial responder 150.46 13.40 100 72453 3591 29876334
Myocardial infarction 148.93 13.40 59 72494 125566 29754359
Rash 148.13 13.40 148 72405 191741 29688184
Septic shock 142.87 13.40 407 72146 63200 29816725
Mantle cell lymphoma recurrent 137.69 13.40 48 72505 375 29879550
White blood cell count decreased 132.71 13.40 476 72077 83471 29796454
Acute lymphocytic leukaemia 129.51 13.40 85 72468 2987 29876938
Cytopenia 126.00 13.40 126 72427 8130 29871795
Neuropathy peripheral 122.11 13.40 412 72141 70063 29809862
Arthralgia 121.38 13.40 91 72462 135700 29744225
Dizziness 121.09 13.40 178 72375 194731 29685194
Central nervous system lymphoma 119.46 13.40 53 72500 827 29879098
Cardiomyopathy 116.91 13.40 163 72390 14980 29864945
Anxiety 115.35 13.40 37 72516 89834 29790091
Death 113.95 13.40 463 72090 356820 29523105
Ejection fraction decreased 113.67 13.40 161 72392 15014 29864911
Sepsis 112.88 13.40 672 71881 145723 29734202
Cytomegalovirus infection 106.08 13.40 199 72354 23475 29856450
Pain 105.89 13.40 159 72394 172482 29707443
Lymphadenopathy 101.97 13.40 199 72354 24177 29855748
Muscle spasms 100.20 13.40 18 72535 64820 29815105
Insomnia 99.35 13.40 51 72502 93285 29786640
Overdose 97.63 13.40 41 72512 84296 29795629
Rhabdomyolysis 97.50 13.40 18 72535 63562 29816363
Herpes simplex 97.01 13.40 83 72470 4381 29875544
Sweat gland tumour 96.40 13.40 37 72516 390 29879535
Epstein-Barr virus infection 96.23 13.40 99 72454 6607 29873318
Fatigue 95.12 13.40 427 72126 320246 29559679
Lymphopenia 94.69 13.40 137 72416 13026 29866899
Headache 94.36 13.40 187 72366 182119 29697806
Hypogammaglobulinaemia 93.03 13.40 87 72466 5165 29874760
Depression 91.04 13.40 53 72500 90384 29789541
Hepatic failure 89.56 13.40 231 72322 33812 29846113
Neoplasm recurrence 89.45 13.40 56 72497 1811 29878114
Somnolence 88.82 13.40 63 72490 96700 29783225
Post transplant lymphoproliferative disorder 88.46 13.40 85 72468 5221 29874704
Pruritus 86.77 13.40 95 72458 118109 29761816
Polyneuropathy 86.43 13.40 124 72429 11699 29868226
Disease recurrence 85.71 13.40 136 72417 14025 29865900
Feeling abnormal 85.04 13.40 17 72536 56739 29823186
Product use issue 84.99 13.40 275 72278 45741 29834184
Blood pressure increased 84.81 13.40 34 72519 71894 29808031
Weight increased 84.19 13.40 38 72515 74875 29805050
Peripheral swelling 84.12 13.40 22 72531 61052 29818873
Cerebrovascular accident 83.91 13.40 49 72504 83428 29796497
Joint swelling 81.96 13.40 9 72544 46937 29832988
Drug interaction 81.53 13.40 232 72321 199336 29680589
Anaemia 81.49 13.40 815 71738 207177 29672748
Drug hypersensitivity 81.42 13.40 32 72521 68487 29811438
Myalgia 81.42 13.40 42 72511 76625 29803300
Venoocclusive liver disease 81.40 13.40 90 72463 6523 29873402
Rheumatoid arthritis 79.88 13.40 5 72548 41192 29838733
B-cell lymphoma 78.52 13.40 74 72479 4436 29875489
Malaise 76.65 13.40 183 72370 166779 29713146
Blood glucose increased 76.02 13.40 27 72526 61503 29818422
Suicidal ideation 74.41 13.40 3 72550 36111 29843814
Tremor 73.27 13.40 46 72507 75317 29804608
Azoospermia 72.41 13.40 30 72523 392 29879533
Acute lymphocytic leukaemia recurrent 71.42 13.40 56 72497 2611 29877314
Intentional product misuse 71.02 13.40 3 72550 34664 29845261
Hallucination 70.83 13.40 16 72537 49043 29830882
Coronary artery disease 70.21 13.40 17 72536 49695 29830230
Stomatitis 69.93 13.40 224 72329 37055 29842870
Left ventricular dysfunction 69.24 13.40 95 72458 8596 29871329
Osteonecrosis 69.02 13.40 133 72420 16002 29863923
Neurotoxicity 66.92 13.40 117 72436 13065 29866860
Blood creatine phosphokinase increased 65.97 13.40 13 72540 43835 29836090
Aspergillus infection 65.85 13.40 101 72452 10113 29869812
Myelopathy 65.79 13.40 47 72506 1900 29878025
Hypoglycaemia 65.36 13.40 21 72532 50960 29828965
Peripheral sensory neuropathy 65.31 13.40 76 72477 5825 29874100
Psoriasis 65.23 13.40 12 72541 42494 29837431
Pain in extremity 65.12 13.40 104 72449 110117 29769808
Aggression 64.62 13.40 7 72546 36900 29843025
Pulmonary toxicity 63.58 13.40 66 72487 4450 29875475
Anaplastic lymphoma kinase gene mutation 62.69 13.40 19 72534 89 29879836
Candida infection 62.52 13.40 124 72429 15238 29864687
Bradycardia 62.32 13.40 41 72512 65485 29814440
Dyspnoea 61.85 13.40 514 72039 332781 29547144
Chest pain 61.35 13.40 120 72433 117507 29762418
Interstitial lung disease 60.97 13.40 298 72255 59899 29820026
Hospitalisation 60.95 13.40 16 72537 44303 29835622
Traumatic lung injury 60.58 13.40 37 72516 1144 29878781
Pneumonitis 58.98 13.40 173 72380 27281 29852644
Drug resistance 58.59 13.40 142 72411 19991 29859934
Salivary gland cancer 57.82 13.40 22 72531 226 29879699
Nasopharyngitis 57.09 13.40 36 72517 58813 29821112
Venoocclusive disease 55.96 13.40 48 72505 2542 29877383
Chronic obstructive pulmonary disease 55.68 13.40 21 72532 46105 29833820
Confusional state 55.54 13.40 156 72397 134678 29745247
Cytogenetic abnormality 54.34 13.40 30 72523 764 29879161
Inappropriate schedule of product administration 53.40 13.40 15 72538 39713 29840212
Aplasia 53.28 13.40 57 72496 3980 29875945
Plasmablastic lymphoma 52.51 13.40 21 72532 249 29879676
Escherichia sepsis 52.02 13.40 56 72497 3938 29875987
Lung infiltration 51.86 13.40 102 72451 12457 29867468
Lymphoma 51.59 13.40 90 72463 10031 29869894
Infection 50.49 13.40 343 72210 77731 29802194
Cardio-respiratory arrest 50.37 13.40 39 72514 57267 29822658
Cytokine release syndrome 50.20 13.40 88 72465 9845 29870080
Abnormal behaviour 50.00 13.40 3 72550 25620 29854305
Colitis 48.81 13.40 175 72378 30645 29849280
Cardiac failure congestive 48.56 13.40 81 72472 84326 29795599
Agitation 48.55 13.40 36 72517 54037 29825888
Abdominal discomfort 48.50 13.40 29 72524 48762 29831163
Post embolisation syndrome 48.16 13.40 14 72539 55 29879870
Plasma cell myeloma 48.07 13.40 256 72297 53206 29826719
Bronchopulmonary aspergillosis 47.41 13.40 97 72456 12187 29867738
Multiple organ dysfunction syndrome 47.24 13.40 289 72264 63198 29816727
Stem cell transplant 47.07 13.40 40 72513 2091 29877834
Malignant transformation 46.23 13.40 26 72527 687 29879238
End stage renal disease 45.81 13.40 72 72481 7363 29872562
Strongyloidiasis 45.71 13.40 41 72512 2305 29877620
Escherichia infection 45.09 13.40 66 72487 6339 29873586
Loss of consciousness 44.90 13.40 77 72476 79298 29800627
Gastritis bacterial 44.73 13.40 17 72536 174 29879751
Gait disturbance 44.67 13.40 70 72483 74707 29805218
Asthma 44.45 13.40 16 72537 36158 29843767
B-cell lymphoma refractory 43.73 13.40 15 72538 111 29879814
Haemophagocytic lymphohistiocytosis 43.47 13.40 82 72471 9709 29870216
Platelet count decreased 43.43 13.40 420 72133 105709 29774216
Refractory cancer 42.94 13.40 15 72538 118 29879807
Gene mutation 42.83 13.40 26 72527 795 29879130
JC virus infection 42.44 13.40 35 72518 1755 29878170
Musculoskeletal stiffness 42.21 13.40 17 72536 35864 29844061
Sleep disorder 41.95 13.40 5 72548 24474 29855451
Refractory anaemia with an excess of blasts 41.71 13.40 20 72533 376 29879549
Viral haemorrhagic cystitis 41.69 13.40 26 72527 835 29879090
Cardiac arrest 41.57 13.40 103 72450 92747 29787178
Injury 41.06 13.40 3 72550 21728 29858197
Epstein-Barr virus associated lymphoma 41.03 13.40 22 72531 528 29879397
Hyperhidrosis 40.84 13.40 62 72491 67028 29812897
Congenital cardiovascular anomaly 40.84 13.40 16 72537 179 29879746
Myelitis transverse 40.53 13.40 27 72526 973 29878952
Blood stem cell transplant failure 40.37 13.40 20 72533 405 29879520
Nephrolithiasis 40.29 13.40 6 72547 24804 29855121
Encephalitis enteroviral 39.87 13.40 15 72538 149 29879776
Injection site pain 39.71 13.40 12 72541 30298 29849627
Skin toxicity 39.61 13.40 44 72509 3205 29876720
Agranulocytosis 39.47 13.40 130 72423 21812 29858113
Lymphoma transformation 39.43 13.40 15 72538 154 29879771
Haemoglobin abnormal 39.23 13.40 43 72510 3086 29876839
Sarcoma metastatic 39.15 13.40 13 72540 86 29879839
Peripheral T-cell lymphoma unspecified 39.09 13.40 21 72532 506 29879419
Incorrect dose administered 38.96 13.40 14 72539 31672 29848253
Drug clearance decreased 38.88 13.40 29 72524 1254 29878671
Arthropathy 38.77 13.40 3 72550 20724 29859201
Peripheral motor neuropathy 38.42 13.40 32 72521 1627 29878298
Contusion 38.15 13.40 14 72539 31266 29848659
Pneumonia klebsiella 36.73 13.40 38 72515 2552 29877373
Staphylococcal sepsis 36.69 13.40 75 72478 9416 29870509
Recurrent cancer 36.58 13.40 27 72526 1149 29878776
Glioma 36.32 13.40 17 72536 302 29879623
Endocarditis noninfective 36.28 13.40 13 72540 111 29879814
Intestinal perforation 36.16 13.40 70 72483 8449 29871476
Wheezing 35.84 13.40 15 72538 30923 29849002
Back pain 35.69 13.40 128 72425 102468 29777457
Memory impairment 35.69 13.40 23 72530 37151 29842774
Plasma cell leukaemia 35.16 13.40 24 72529 901 29879024
Neutropenic infection 35.11 13.40 25 72528 1005 29878920
Gastrointestinal toxicity 35.05 13.40 33 72520 1975 29877950
Angioedema 34.78 13.40 20 72533 34364 29845561
Osteosarcoma recurrent 34.75 13.40 9 72544 20 29879905
Hyperkalaemia 34.68 13.40 67 72486 65943 29813982
Autoimmune neutropenia 34.66 13.40 16 72537 275 29879650
Infection reactivation 34.53 13.40 24 72529 928 29878997
Drug withdrawal syndrome 34.06 13.40 4 72549 19805 29860120
Gastric perforation 34.05 13.40 33 72520 2048 29877877
Neutropenic colitis 33.96 13.40 34 72519 2196 29877729
Chloroma 33.72 13.40 18 72535 428 29879497
Urticaria 33.68 13.40 50 72503 54556 29825369
Osteoarthritis 33.37 13.40 3 72550 18346 29861579
Cystitis haemorrhagic 33.22 13.40 49 72504 4738 29875187
Balance disorder 33.13 13.40 24 72529 36469 29843456
Hepatic fibrosis 32.94 13.40 42 72511 3538 29876387
Therapy non-responder 32.86 13.40 150 72403 29303 29850622
Unevaluable event 32.86 13.40 18 72535 31767 29848158
Ganglioneuroblastoma 32.82 13.40 9 72544 27 29879898
Device related infection 32.58 13.40 103 72450 16912 29863013
Autoimmune lymphoproliferative syndrome 32.52 13.40 13 72540 154 29879771
Hepatosplenic candidiasis 32.48 13.40 14 72539 203 29879722
Guillain-Barre syndrome 32.39 13.40 50 72503 5033 29874892
International normalised ratio increased 32.16 13.40 41 72512 47698 29832227
Adenoviral hepatitis 32.14 13.40 13 72540 159 29879766
Hypertension 32.07 13.40 168 72385 121186 29758739
B precursor type acute leukaemia 32.00 13.40 11 72542 82 29879843
Toxicity to various agents 31.94 13.40 275 72278 176908 29703017
Haematochezia 31.74 13.40 22 72531 34200 29845725
Neuroblastoma 31.46 13.40 14 72539 220 29879705
Restlessness 31.37 13.40 8 72545 22591 29857334
Vision blurred 31.31 13.40 33 72520 41783 29838142
Splenic lesion 31.22 13.40 12 72541 127 29879798
Loss of personal independence in daily activities 31.12 13.40 7 72546 21528 29858397
Computerised tomogram coronary artery abnormal 30.15 13.40 6 72547 0 29879925
Transformation to acute myeloid leukaemia 30.00 13.40 19 72534 627 29879298
Oedema peripheral 29.97 13.40 143 72410 105689 29774236
Extravasation 29.93 13.40 29 72524 1799 29878126
Respiratory arrest 29.62 13.40 17 72536 29241 29850684
Subdural hygroma 29.61 13.40 15 72538 319 29879606
Product quality issue 29.45 13.40 5 72548 18769 29861156
Cardiomyopathy acute 29.42 13.40 8 72545 23 29879902
Pneumocystis jirovecii infection 29.21 13.40 25 72528 1320 29878605
Enterovirus infection 29.09 13.40 18 72535 570 29879355
Primitive neuroectodermal tumour 28.92 13.40 10 72543 76 29879849
West Nile viral infection 28.73 13.40 18 72535 583 29879342
Fungal infection 28.53 13.40 85 72468 13515 29866410
Device related thrombosis 28.42 13.40 20 72533 789 29879136
Pneumonia 28.38 13.40 1032 71521 333274 29546651
Chronic myeloid leukaemia 28.20 13.40 33 72520 2544 29877381
Syncope 28.16 13.40 108 72445 84795 29795130
Herpes simplex encephalitis 28.14 13.40 14 72539 286 29879639
Heart rate decreased 28.07 13.40 8 72545 20986 29858939
Mobility decreased 27.94 13.40 14 72539 25985 29853940
Anaplastic large-cell lymphoma 27.71 13.40 12 72541 176 29879749
Diarrhoea 27.69 13.40 608 71945 333495 29546430
Haemorrhage 27.63 13.40 43 72510 46036 29833889
Cardiac dysfunction 27.54 13.40 23 72530 1174 29878751
Neurofibrosarcoma 27.41 13.40 8 72545 32 29879893
Tidal volume decreased 27.41 13.40 8 72545 32 29879893
Rhabdomyosarcoma recurrent 27.35 13.40 10 72543 91 29879834
Bone marrow necrosis 27.02 13.40 11 72542 137 29879788
Mucosal toxicity 26.89 13.40 12 72541 190 29879735
Pleural effusion 26.86 13.40 286 72267 73780 29806145
Acute myelomonocytic leukaemia 26.81 13.40 11 72542 140 29879785
Nephropathy toxic 26.74 13.40 71 72482 10568 29869357
Respiratory failure 26.61 13.40 366 72187 100276 29779649
Chronic lymphocytic leukaemia refractory 26.52 13.40 10 72543 100 29879825
Accidental overdose 26.29 13.40 6 72547 18269 29861656
Fluid retention 26.07 13.40 14 72539 24984 29854941
Clostridium difficile colitis 26.03 13.40 79 72474 12689 29867236
Metastases to retroperitoneum 26.01 13.40 12 72541 206 29879719
5q minus syndrome 26.00 13.40 11 72542 152 29879773
Acute lymphocytic leukaemia refractory 25.92 13.40 10 72543 107 29879818
Hepatic infection fungal 25.87 13.40 11 72542 154 29879771
Depressed mood 25.71 13.40 5 72548 17024 29862901
Plasmacytoma 25.71 13.40 36 72517 3320 29876605
Intestinal atresia 25.63 13.40 9 72544 72 29879853
Hypertriglyceridaemia 25.60 13.40 59 72494 8039 29871886
Drug reaction with eosinophilia and systemic symptoms 25.52 13.40 19 72534 28469 29851456
Metastases to lung 25.49 13.40 58 72495 7837 29872088
Irritability 25.40 13.40 12 72541 23038 29856887
Chylothorax 25.26 13.40 17 72536 623 29879302
Lactic acidosis 25.25 13.40 23 72530 31190 29848735
Biliary-bronchial fistula 25.13 13.40 5 72548 0 29879925
Immunosuppression 25.06 13.40 45 72508 5130 29874795
Diffuse large B-cell lymphoma stage IV 25.01 13.40 12 72541 226 29879699
Electrocardiogram QT prolonged 24.95 13.40 30 72523 35805 29844120
Acute lung injury 24.91 13.40 21 72532 1086 29878839
Product administration error 24.48 13.40 3 72550 14374 29865551
Disorientation 24.43 13.40 24 72529 31394 29848531
Mantle cell lymphoma 24.40 13.40 24 72529 1517 29878408
Pseudomonas infection 24.39 13.40 68 72485 10414 29869511
Pulmonary embolism 24.39 13.40 293 72260 77842 29802083
Blastic plasmacytoid dendritic cell neoplasia 24.23 13.40 9 72544 86 29879839
T-cell type acute leukaemia 24.21 13.40 11 72542 182 29879743
Pseudomonal sepsis 24.21 13.40 33 72520 2967 29876958
Osteosarcoma 24.05 13.40 11 72542 185 29879740
Stomatitis necrotising 23.96 13.40 9 72544 89 29879836
Abdominal pain upper 23.82 13.40 75 72478 62476 29817449
Head injury 23.67 13.40 6 72547 17014 29862911
Transient ischaemic attack 23.63 13.40 16 72537 25184 29854741
Metastases to spleen 23.59 13.40 13 72540 330 29879595
Morphoea 23.45 13.40 10 72543 141 29879784
Cerebral toxoplasmosis 23.44 13.40 23 72530 1449 29878476
Testicular disorder 23.36 13.40 16 72537 604 29879321
Mucormycosis 23.23 13.40 44 72509 5224 29874701
Cardiac disorder 23.19 13.40 38 72515 39855 29840070
Metastases to muscle 23.17 13.40 11 72542 202 29879723
Molluscum contagiosum 23.16 13.40 12 72541 268 29879657
Chest discomfort 23.16 13.40 47 72506 45433 29834492
Cutaneous T-cell lymphoma recurrent 23.06 13.40 7 72546 33 29879892
Rash pruritic 23.01 13.40 13 72540 22559 29857366
Positron emission tomogram abnormal 22.95 13.40 9 72544 101 29879824
Enterovesical fistula 22.92 13.40 16 72537 623 29879302
Dysgeusia 22.92 13.40 16 72537 24785 29855140
Infusion site discolouration 22.71 13.40 9 72544 104 29879821
Klebsiella infection 22.68 13.40 51 72502 6836 29873089
Bacteraemia 22.65 13.40 86 72467 15474 29864451
Myeloid leukaemia 22.63 13.40 13 72540 358 29879567
Liver function test abnormal 22.53 13.40 25 72528 30925 29849000
Psychotic disorder 22.50 13.40 12 72541 21503 29858422
Gastrooesophageal reflux disease 22.46 13.40 27 72526 32228 29847697
Pneumaturia 22.40 13.40 7 72546 37 29879888
Blood HIV RNULL increased 22.32 13.40 22 72531 1394 29878531
Hepatic amoebiasis 22.26 13.40 8 72545 69 29879856
Splenic marginal zone lymphoma 22.09 13.40 7 72546 39 29879886
Haematopoietic stem cell mobilisation 21.82 13.40 10 72543 169 29879756
Pulmonary sarcoidosis 21.79 13.40 15 72538 571 29879354
Congestive cardiomyopathy 21.74 13.40 49 72504 6578 29873347
Pneumonia fungal 21.71 13.40 44 72509 5489 29874436
Bone marrow disorder 21.63 13.40 22 72531 1448 29878477
Bacterial sepsis 21.55 13.40 41 72512 4885 29875040
Palmar-plantar erythrodysaesthesia syndrome 21.49 13.40 82 72471 14788 29865137
Burkitt's lymphoma 21.40 13.40 10 72543 177 29879748
Cellulitis gangrenous 21.40 13.40 10 72543 177 29879748
Periorbital infection 21.29 13.40 9 72544 124 29879801
Sphingomonas paucimobilis infection 21.25 13.40 7 72546 45 29879880
Metastases to bone marrow 21.25 13.40 14 72539 495 29879430
BK virus infection 21.20 13.40 38 72515 4326 29875599
Hypersensitivity 21.12 13.40 64 72489 53964 29825961
Pneumothorax spontaneous 21.03 13.40 13 72540 411 29879514
Lip swelling 20.88 13.40 3 72550 12741 29867184
Hepatitis B DNULL increased 20.81 13.40 14 72539 513 29879412
Amnesia 20.80 13.40 17 72536 24304 29855621
Secondary immunodeficiency 20.78 13.40 12 72541 334 29879591
Superior vena cava syndrome 20.56 13.40 13 72540 428 29879497
Abdominal neoplasm 20.48 13.40 10 72543 196 29879729
Congenital herpes simplex infection 20.38 13.40 7 72546 52 29879873
Acute hepatic failure 20.31 13.40 69 72484 11758 29868167
Ileus 20.24 13.40 83 72470 15472 29864453
Salivary gland neoplasm 20.17 13.40 6 72547 26 29879899
Blood urea increased 20.07 13.40 28 72525 31353 29848572
Blood cholesterol increased 20.02 13.40 8 72545 16962 29862963
Ichthyosis 19.99 13.40 8 72545 95 29879830
Pneumonia salmonella 19.99 13.40 6 72547 27 29879898
Treatment noncompliance 19.97 13.40 19 72534 25234 29854691
Renal tubular disorder 19.87 13.40 40 72513 4966 29874959
Fanconi syndrome 19.87 13.40 23 72530 1752 29878173
Phlebitis infective 19.80 13.40 9 72544 149 29879776
Focal nodular hyperplasia 19.75 13.40 9 72544 150 29879775
Wrong technique in product usage process 19.72 13.40 28 72525 31127 29848798
Candida endophthalmitis 19.70 13.40 8 72545 99 29879826
Mucoepidermoid carcinoma of salivary gland 19.66 13.40 5 72548 10 29879915
Swollen tongue 19.65 13.40 4 72549 13188 29866737
Marginal zone lymphoma recurrent 19.64 13.40 6 72547 29 29879896
Adrenocortical carcinoma 19.64 13.40 6 72547 29 29879896
Granulocytopenia neonatal 19.64 13.40 6 72547 29 29879896
Unresponsive to stimuli 19.61 13.40 21 72532 26398 29853527
Stevens-Johnson syndrome 19.56 13.40 9 72544 17547 29862378
Lymphocytosis 19.54 13.40 24 72529 1946 29877979
Renal disorder 19.53 13.40 17 72536 23567 29856358
Influenza 19.52 13.40 48 72505 43350 29836575
Intentional product use issue 19.46 13.40 153 72400 36287 29843638
Nightmare 19.42 13.40 3 72550 12073 29867852
Prostatic specific antigen increased 19.27 13.40 3 72550 12001 29867924
Faeces discoloured 19.23 13.40 5 72548 13941 29865984
Gastric stenosis 19.16 13.40 6 72547 32 29879893
Streptococcal infection 19.15 13.40 38 72515 4670 29875255
Burning sensation 19.06 13.40 8 72545 16466 29863459
Sinusitis bacterial 19.05 13.40 11 72542 306 29879619
Metastasis 19.03 13.40 31 72522 3267 29876658
Injection site erythema 19.00 13.40 5 72548 13829 29866096
Herpes zoster 19 13.40 131 72422 29812 29850113
Small intestinal perforation 19.00 13.40 22 72531 1677 29878248
Suspected product quality issue 18.97 13.40 9 72544 165 29879760
Dry skin 18.82 13.40 16 72537 22438 29857487
Adverse drug reaction 18.79 13.40 17 72536 23128 29856797
Neck pain 18.72 13.40 14 72539 20930 29858995
Glioblastoma multiforme 18.66 13.40 16 72537 847 29879078
Hepatotoxicity 18.47 13.40 90 72463 18055 29861870
Cardiac failure 18.37 13.40 294 72259 83124 29796801
Oesophageal candidiasis 18.36 13.40 35 72518 4175 29875750
Peripheral sensorimotor neuropathy 18.36 13.40 19 72534 1276 29878649
Total lung capacity decreased 18.36 13.40 14 72539 626 29879299
Adenocarcinoma gastric 18.36 13.40 18 72535 1133 29878792
Surgery 18.29 13.40 3 72550 11548 29868377
Sleep apnoea syndrome 18.23 13.40 9 72544 16848 29863077
Acute respiratory distress syndrome 18.17 13.40 108 72445 23364 29856561
Taeniasis 18.05 13.40 7 72546 76 29879849
Scleroderma 17.98 13.40 19 72534 1308 29878617
Cutaneous T-cell lymphoma 17.88 13.40 19 72534 1316 29878609
Dyskinesia 17.77 13.40 16 72537 21818 29858107
Leiomyosarcoma 17.68 13.40 8 72545 131 29879794
Plasma cell myeloma refractory 17.66 13.40 6 72547 43 29879882
Swelling 17.62 13.40 38 72515 35937 29843988
Hepatitis D 17.54 13.40 6 72547 44 29879881
Peripheral T-cell lymphoma unspecified stage III 17.54 13.40 6 72547 44 29879881
Diaphragm muscle weakness 17.50 13.40 7 72546 83 29879842
Musculoskeletal pain 17.49 13.40 30 72523 30910 29849015
Human herpesvirus 8 infection 17.45 13.40 14 72539 675 29879250
Premature ageing 17.43 13.40 7 72546 84 29879841
IIIrd nerve paresis 17.43 13.40 7 72546 84 29879841
Cryptococcal fungaemia 17.43 13.40 7 72546 84 29879841
Acute promyelocytic leukaemia 17.41 13.40 13 72540 563 29879362
Anger 17.36 13.40 3 72550 11117 29868808
Nausea 17.32 13.40 568 71985 296389 29583536
Central nervous system enteroviral infection 17.31 13.40 6 72547 46 29879879
Chronic lymphocytic leukaemia 17.22 13.40 36 72517 4592 29875333
Candida sepsis 17.18 13.40 17 72536 1082 29878843
Helicobacter sepsis 17.13 13.40 5 72548 20 29879905
Leukoencephalopathy 17.12 13.40 33 72520 3969 29875956
Disturbance in attention 17.09 13.40 17 72536 22112 29857813
Postural tremor 16.95 13.40 10 72543 290 29879635
Staphylococcal bacteraemia 16.84 13.40 45 72508 6723 29873202
Adenovirus infection 16.82 13.40 34 72519 4234 29875691
Hypophosphataemia 16.79 13.40 51 72502 8194 29871731
Chemotherapeutic drug level increased 16.71 13.40 9 72544 218 29879707
Weight decreased 16.71 13.40 261 72292 150660 29729265
Viral load increased 16.70 13.40 27 72526 2827 29877098
Hypoaesthesia 16.70 13.40 71 72482 54159 29825766
Empyema 16.69 13.40 27 72526 2829 29877096
Cerebral venous sinus thrombosis 16.67 13.40 10 72543 299 29879626
Blindness cortical 16.61 13.40 10 72543 301 29879624
Retinal haemorrhage 16.61 13.40 36 72517 4707 29875218
Clostridium difficile infection 16.58 13.40 79 72474 15704 29864221
Meningitis enteroviral 16.57 13.40 6 72547 53 29879872
Hypercalcaemia 16.52 13.40 67 72486 12428 29867497
Disseminated cryptococcosis 16.51 13.40 16 72537 993 29878932
Heart rate increased 16.51 13.40 44 72509 38677 29841248
Laboratory test abnormal 16.45 13.40 11 72542 17431 29862494
Escherichia bacteraemia 16.37 13.40 27 72526 2875 29877050
Erythema 16.36 13.40 115 72438 77336 29802589
Gait inability 16.32 13.40 13 72540 18828 29861097
Eczema 16.27 13.40 6 72547 13363 29866562
Lymphadenitis viral 16.23 13.40 5 72548 25 29879900
Influenza like illness 16.22 13.40 23 72530 25582 29854343
Emotional distress 16.19 13.40 9 72544 15756 29864169
Blood pressure decreased 16.17 13.40 59 72494 47016 29832909
Paresis 16.03 13.40 21 72532 1817 29878108
Bone marrow infiltration 16.03 13.40 7 72546 105 29879820
Encephalopathy 15.99 13.40 133 72420 32072 29847853
Pancreatitis 15.91 13.40 41 72512 36449 29843476
Escherichia test positive 15.88 13.40 16 72537 1041 29878884
Embolism 15.85 13.40 45 72508 6964 29872961
Mantle cell lymphoma stage IV 15.82 13.40 6 72547 61 29879864
Respiratory tract infection fungal 15.79 13.40 13 72540 650 29879275
Fusarium infection 15.79 13.40 16 72537 1048 29878877
Pneumonia cytomegaloviral 15.75 13.40 26 72527 2770 29877155
Systemic mycosis 15.75 13.40 17 72536 1199 29878726
Abdominal wound dehiscence 15.73 13.40 7 72546 110 29879815
Asthenia 15.71 13.40 412 72141 220878 29659047
Neutrophil count abnormal 15.70 13.40 18 72535 1357 29878568
Vertigo 15.70 13.40 19 72534 22616 29857309
Diffuse large B-cell lymphoma stage III 15.65 13.40 6 72547 63 29879862
Hot flush 15.63 13.40 8 72545 14672 29865253
Chromosome analysis abnormal 15.62 13.40 7 72546 112 29879813
Congenital hepatobiliary anomaly 15.61 13.40 5 72548 29 29879896
Pulmonary fibrosis 15.59 13.40 78 72475 15812 29864113
Cytomegalovirus infection reactivation 15.59 13.40 20 72533 1695 29878230
Swelling face 15.57 13.40 17 72536 21187 29858738
Venous thrombosis 15.50 13.40 28 72525 3206 29876719
Malignant fibrous histiocytoma 15.45 13.40 7 72546 115 29879810
Hallucination, visual 15.42 13.40 10 72543 16103 29863822
Leukonychia 15.41 13.40 4 72549 9 29879916
Bacterial infection 15.40 13.40 66 72487 12544 29867381
Coronary artery occlusion 15.39 13.40 4 72549 11153 29868772
White blood cell disorder 15.34 13.40 17 72536 1235 29878690
Paternal exposure timing unspecified 15.33 13.40 5 72548 31 29879894
Lewis-Sumner syndrome 15.33 13.40 5 72548 31 29879894
Therapy responder 15.30 13.40 8 72545 182 29879743
Wound evisceration 15.29 13.40 7 72546 118 29879807
Heart disease congenital 15.27 13.40 17 72536 1241 29878684
Mastitis 15.27 13.40 8 72545 183 29879742
Delirium 15.26 13.40 49 72504 40582 29839343
H1N1 influenza 15.24 13.40 15 72538 949 29878976
Gastrosplenic fistula 15.20 13.40 5 72548 32 29879893
Diabetic ketoacidosis 15.19 13.40 10 72543 15976 29863949
Leiomyosarcoma metastatic 15.12 13.40 4 72549 10 29879915
Cholelithiasis 15.09 13.40 16 72537 20209 29859716
Diabetes mellitus inadequate control 15.08 13.40 6 72547 12756 29867169
Ureteric compression 15.07 13.40 5 72548 33 29879892
Visual impairment 15.03 13.40 32 72521 30406 29849519
Organising pneumonia 14.98 13.40 36 72517 5038 29874887
Blood pressure systolic increased 14.98 13.40 9 72544 15101 29864824
Metabolic acidosis 14.91 13.40 44 72509 37417 29842508
Gastrointestinal haemorrhage 14.79 13.40 130 72423 83316 29796609
Psoriatic arthropathy 14.79 13.40 10 72543 15751 29864174
Haemoperitoneum 14.78 13.40 18 72535 1447 29878478
Vascular injury 14.71 13.40 9 72544 279 29879646
Cancer fatigue 14.69 13.40 5 72548 36 29879889
Genotoxicity 14.69 13.40 5 72548 36 29879889
Hepatitis viral 14.62 13.40 11 72542 482 29879443
Pneumonia aspiration 14.59 13.40 45 72508 37735 29842190
Peripheral T-cell lymphoma unspecified refractory 14.59 13.40 4 72549 12 29879913
B-cell type acute leukaemia 14.57 13.40 9 72544 284 29879641
Injection site reaction 14.57 13.40 4 72549 10756 29869169
Administration site extravasation 14.43 13.40 10 72543 385 29879540
Febrile infection 14.30 13.40 19 72534 1666 29878259
Hepatitis 14.30 13.40 98 72455 22258 29857667
Clostridium test positive 14.20 13.40 21 72532 2035 29877890
Nervous system disorder 14.16 13.40 66 72487 13003 29866922
Acute pulmonary histoplasmosis 14.11 13.40 6 72547 84 29879841
Treatment failure 14.03 13.40 137 72416 34542 29845383
Therapeutic product effect decreased 14.00 13.40 31 72522 29045 29850880
Splenic candidiasis 13.98 13.40 6 72547 86 29879839
Human polyomavirus infection 13.95 13.40 12 72541 638 29879287
Benign prostatic hyperplasia 13.93 13.40 4 72549 10443 29869482
Lymphoplasmacytoid lymphoma/immunocytoma 13.92 13.40 5 72548 43 29879882
Oxygen saturation decreased 13.92 13.40 56 72497 43384 29836541
Hypersomnia 13.91 13.40 5 72548 11311 29868614
Seizure 13.89 13.40 162 72391 98313 29781612
Abdominal mass 13.85 13.40 16 72537 1216 29878709
Chronic myelomonocytic leukaemia 13.85 13.40 12 72541 644 29879281
Non-Hodgkin's lymphoma unspecified histology aggressive 13.82 13.40 5 72548 44 29879881
Spinal cord ischaemia 13.80 13.40 6 72547 89 29879836
Hip deformity 13.80 13.40 6 72547 89 29879836
Skin laceration 13.78 13.40 5 72548 11246 29868679
Colitis ulcerative 13.75 13.40 9 72544 14425 29865500
Respiratory tract infection 13.75 13.40 74 72479 15432 29864493
Mental status changes 13.73 13.40 45 72508 37034 29842891
Coxsackie viral infection 13.70 13.40 4 72549 16 29879909
T-cell lymphoma 13.62 13.40 14 72539 933 29878992
Skin exfoliation 13.53 13.40 22 72531 23150 29856775
Diffuse large B-cell lymphoma stage II 13.53 13.40 5 72548 47 29879878
Hip fracture 13.53 13.40 5 72548 11119 29868806
Granulocyte count decreased 13.49 13.40 12 72541 667 29879258

Pharmacologic Action:

SourceCodeDescription
ATC L01DB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
FDA CS M0028312 Anthracyclines
FDA MoA N0000000176 Topoisomerase Inhibitors
FDA EPC N0000175414 Anthracycline Topoisomerase Inhibitor
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
CHEBI has role CHEBI:76971 e.coli metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute myeloid leukemia, disease indication 91861009
Kaposi's sarcoma indication 109385007
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Small cell carcinoma of lung indication 254632001 DOID:5409
Carcinoma of breast indication 254838004 DOID:3459
Nephroblastoma indication 302849000 DOID:2154
Osteosarcoma of bone indication 307576001 DOID:3376
Follicular non-Hodgkin's lymphoma indication 308121000
Malignant tumor of lung indication 363358000
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Kaposi's sarcoma associated with AIDS indication 420524008
Neuroblastoma indication 432328008 DOID:769
Carcinoma of female breast indication 447782002
Soft or Connective Tissue Sarcoma indication
Invasive Bladder Malignancy indication
Metastatic Breast Carcinoma indication
Metastatic Gastric Cancer indication
Carcinoid syndrome off-label use 35868009
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Malignant neoplasm of liver off-label use 93870000 DOID:3571
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Primary cutaneous T-cell lymphoma off-label use 400122007
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Pancreatic Neuroendocrine Tumor off-label use
Mycosis contraindication 3218000 DOID:1564
Bundle branch block contraindication 6374002
Hyperbilirubinemia contraindication 14783006 DOID:2741
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Conduction disorder of the heart contraindication 44808001
Myocarditis contraindication 50920009 DOID:820
Heart disease contraindication 56265001 DOID:114
Hepatic failure contraindication 59927004
Heart failure contraindication 84114007 DOID:6000
Leukopenia contraindication 84828003 DOID:615
Cardiomyopathy contraindication 85898001 DOID:0050700
Bacterial infectious disease contraindication 87628006
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Atrioventricular block contraindication 233917008 DOID:0050820
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Asymptomatic left ventricular systolic dysfunction contraindication 698592004
Protozoal Infection contraindication
Severe Cardiac Disease contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.85 acidic
pKa2 9.21 acidic
pKa3 9.92 acidic
pKa4 11.11 acidic
pKa5 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 6 CHEMBL CHEMBL
Caspase-1 Enzyme IC50 4.91 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.29 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.60 DRUG MATRIX
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Telomerase reverse transcriptase Enzyme IC50 4.14 CHEMBL
DNA topoisomerase 1 Enzyme IC50 4.70 CHEMBL
Aurora kinase A Kinase IC50 7.40 CHEMBL
72 kDa type IV collagenase Enzyme IC50 5.96 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.43 DRUG MATRIX
5-hydroxytryptamine receptor 4 GPCR Ki 5.68 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 4.87 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 4.81 DRUG MATRIX
Type-2 restriction enzyme HindIII Unclassified IC50 4.02 CHEMBL
Type-2 restriction enzyme ScaI Unclassified IC50 4.60 CHEMBL
Ribonuclease pancreatic Enzyme IC50 4.60 CHEMBL
Integrase Enzyme IC50 6.05 CHEMBL
ORF 73 Unclassified AC50 5.84 CHEMBL
UDP-galactopyranose mutase Unclassified AC50 4.49 CHEMBL
Reverse transcriptase Enzyme IC50 4.28 CHEMBL

External reference:

IDSource
4019737 VUID
N0000147829 NUI
D01275 KEGG_DRUG
25316-40-9 SECONDARY_CAS_RN
4018106 VANDF
4019737 VANDF
C0085752 UMLSCUI
CHEBI:28748 CHEBI
DM2 PDB_CHEM_ID
CHEMBL53463 ChEMBL_ID
CHEMBL359744 ChEMBL_ID
31703 PUBCHEM_CID
DB00997 DRUGBANK_ID
D004317 MESH_DESCRIPTOR_UI
C506643 MESH_SUPPLEMENTAL_RECORD_UI
7069 IUPHAR_LIGAND_ID
3005 INN_ID
80168379AG UNII
142433 RXNORM
3368 MMSL
4639 MMSL
47543 MMSL
47549 MMSL
d00218 MMSL
d04004 MMSL
002659 NDDF
004818 NDDF
372817009 SNOMEDCT_US
428681007 SNOMEDCT_US
68444001 SNOMEDCT_US
90875009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3030 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3032 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3033 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3034 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4004 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4015 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4026 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4030 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4032 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4033 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4034 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4037 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9084 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9085 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9086 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9087 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9088 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9089 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9090 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9091 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9092 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9093 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9275 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9277 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9369 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9370 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9371 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9372 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections