doxorubicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 960 23214-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxorubicin
  • hydroxydaunomycin
  • hydroxydaunorubicin
  • rubidox
  • doxorubicin hydrochloride
  • liposomal doxorubicin
  • hydroxydaunorubicin hydrochloride
  • adriamycin
  • doxorubicin HCl
  • hydroxydaunorubicin HCl
  • adriacin
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
  • Molecular weight: 543.53
  • Formula: C27H29NO11
  • CLOGP: 0.26
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 6
  • TPSA: 206.07
  • ALOGS: -2.67
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.47 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.28 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 32 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1974 FDA
June 20, 1996 EMA BAXTER HOLDING B.V.
March 1, 1975 PMDA SANDOZ PHARMA K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5745.12 12.78 3151 105228 115298 63265345
Neutropenia 2913.74 12.78 2397 105982 172608 63208035
Disease progression 1930.56 12.78 1629 106750 121129 63259514
Acute myeloid leukaemia 1221.84 12.78 593 107786 16554 63364089
Cardiotoxicity 1103.73 12.78 447 107932 7991 63372652
Mucosal inflammation 1018.69 12.78 754 107625 46174 63334469
Thrombocytopenia 988.04 12.78 1252 107127 149905 63230738
Myelodysplastic syndrome 945.93 12.78 495 107884 16259 63364384
Haematotoxicity 897.67 12.78 398 107981 8978 63371665
Second primary malignancy 870.39 12.78 371 108008 7582 63373061
Malignant neoplasm progression 868.20 12.78 874 107505 81247 63299396
Pancytopenia 736.72 12.78 867 107512 96066 63284577
Palmar-plantar erythrodysaesthesia syndrome 704.47 12.78 457 107922 22558 63358085
Diffuse large B-cell lymphoma recurrent 655.94 12.78 217 108162 2103 63378540
Bone marrow failure 638.45 12.78 472 107907 28818 63351825
Cardiomyopathy 627.92 12.78 385 107994 17199 63363444
Neoplasm progression 601.15 12.78 498 107881 35930 63344713
Off label use 560.92 12.78 2452 105927 672010 62708633
Ejection fraction decreased 548.61 12.78 387 107992 21945 63358698
Anaemia 522.01 12.78 1379 107000 292051 63088592
Febrile bone marrow aplasia 520.63 12.78 253 108126 7072 63373571
Product use in unapproved indication 509.87 12.78 1014 107365 178066 63202577
Joint swelling 477.43 12.78 19 108360 327647 63052996
Hepatitis B reactivation 468.76 12.78 183 108196 2954 63377689
Pneumocystis jirovecii pneumonia 450.33 12.78 308 108071 16606 63364037
Myelosuppression 426.73 12.78 341 108038 23362 63357281
Metastases to bone 409.90 12.78 317 108062 20702 63359941
Rheumatoid arthritis 406.82 12.78 5 108374 253814 63126829
Neuropathy peripheral 388.21 12.78 696 107683 112971 63267672
Cardiac failure 381.77 12.78 604 107775 88538 63292105
Tumour lysis syndrome 376.02 12.78 218 108161 8772 63371871
Leukopenia 373.66 12.78 554 107825 76736 63303907
Pain 352.52 12.78 450 107929 740178 62640465
Left ventricular dysfunction 351.98 12.78 232 108147 11756 63368887
Abdominal discomfort 343.17 12.78 66 108313 320819 63059824
Systemic lupus erythematosus 335.25 12.78 4 108375 208914 63171729
Contraindicated product administered 329.66 12.78 9 108370 217639 63163004
Ovarian failure 324.72 12.78 111 108268 1199 63379444
Septic shock 316.88 12.78 474 107905 66155 63314488
Neutrophil count decreased 308.78 12.78 429 107950 55977 63324666
Therapy partial responder 305.01 12.78 203 108176 10455 63370188
Metastases to liver 304.95 12.78 281 108098 23358 63357285
Fall 304.14 12.78 145 108234 392189 62988454
Arthropathy 301.61 12.78 27 108352 234765 63145878
Cytopenia 301.12 12.78 208 108171 11393 63369250
Metastases to lung 290.23 12.78 211 108168 12539 63368104
Sepsis 287.32 12.78 735 107644 152388 63228255
Synovitis 285.79 12.78 7 108372 186911 63193732
Arthralgia 285.61 12.78 332 108047 569378 62811265
Pyrexia 285.56 12.78 1566 106813 468912 62911731
Swelling 285.29 12.78 61 108318 275317 63105326
Headache 275.59 12.78 410 107969 632831 62747812
Diffuse large B-cell lymphoma refractory 269.29 12.78 95 108284 1135 63379508
Product dose omission issue 263.92 12.78 42 108337 234271 63146372
Peripheral swelling 255.67 12.78 69 108310 265873 63114770
Nasopharyngitis 253.98 12.78 61 108318 254196 63126447
Disease recurrence 252.24 12.78 274 108105 27756 63352887
Bone pain 250.23 12.78 382 107997 54259 63326384
Neutropenic sepsis 244.93 12.78 212 108167 16226 63364417
Drug hypersensitivity 243.45 12.78 113 108266 310574 63070069
Therapeutic product effect decreased 240.72 12.78 25 108354 193162 63187481
Pruritus 240.68 12.78 161 108218 361292 63019351
Musculoskeletal stiffness 234.99 12.78 22 108357 184596 63196047
Completed suicide 232.70 12.78 3 108376 145670 63234973
Congestive cardiomyopathy 229.98 12.78 139 108240 6043 63374600
Wound 226.18 12.78 13 108366 163250 63217393
Weight increased 218.39 12.78 86 108293 260706 63119937
Staphylococcal bacteraemia 215.21 12.78 128 108251 5402 63375241
Posterior reversible encephalopathy syndrome 213.71 12.78 201 108178 17144 63363499
Acute promyelocytic leukaemia 208.31 12.78 73 108306 854 63379789
Neutropenic colitis 208.26 12.78 103 108276 2992 63377651
Sinusitis 199.41 12.78 69 108310 226584 63154059
Neurotoxicity 190.63 12.78 187 108192 16803 63363840
Drug intolerance 186.60 12.78 152 108227 308509 63072134
Rash 182.92 12.78 432 107947 560439 62820204
Ascites 182.60 12.78 282 108097 40446 63340197
Metastases to lymph nodes 181.12 12.78 133 108246 8025 63372618
Dizziness 166.40 12.78 300 108079 429625 62951018
Pericarditis 161.38 12.78 18 108361 131561 63249082
Pleural effusion 160.95 12.78 434 107945 92776 63287867
Interstitial lung disease 160.90 12.78 338 108041 61570 63319073
Pneumonitis 159.47 12.78 245 108134 34977 63345666
Hepatitis B 158.24 12.78 92 108287 3720 63376923
Hepatic enzyme increased 157.72 12.78 74 108305 202254 63178389
Discomfort 155.97 12.78 46 108333 167328 63213315
Contusion 153.70 12.78 34 108345 150010 63230633
Blood lactate dehydrogenase increased 149.77 12.78 191 108188 22925 63357718
Polyneuropathy 149.74 12.78 153 108226 14436 63366207
Breast cancer metastatic 145.62 12.78 138 108241 11880 63368763
Anti-Muellerian hormone level decreased 144.85 12.78 34 108345 70 63380573
Platelet count decreased 143.98 12.78 481 107898 115641 63265002
Insomnia 141.59 12.78 97 108282 215155 63165488
Multiple organ dysfunction syndrome 138.44 12.78 302 108077 56450 63324193
Injection site pain 137.92 12.78 27 108352 129773 63250870
Psoriatic arthropathy 137.68 12.78 4 108375 91516 63289127
Urticaria 136.54 12.78 56 108323 165746 63214897
Progressive multifocal leukoencephalopathy 134.89 12.78 137 108242 12834 63367809
Peripheral sensory neuropathy 133.64 12.78 107 108272 7344 63373299
Post transplant lymphoproliferative disorder 132.42 12.78 91 108288 4940 63375703
Psoriasis 130.08 12.78 4 108375 86953 63293690
Aplasia 128.85 12.78 84 108295 4175 63376468
Lymphadenopathy 126.66 12.78 232 108147 38226 63342417
Muscle spasms 124.96 12.78 55 108324 156095 63224548
Pain in extremity 124.86 12.78 235 108144 331251 63049392
Asthma 124.55 12.78 32 108347 127529 63253114
Anxiety 121.85 12.78 115 108264 217426 63163217
Arthritis 121.30 12.78 25 108354 115896 63264747
Breast cancer recurrent 120.15 12.78 81 108298 4260 63376383
Blood cholesterol increased 120.14 12.78 11 108368 94021 63286622
Fibromyalgia 119.22 12.78 4 108375 80416 63300227
Feeling abnormal 119.16 12.78 52 108327 148340 63232303
Acute lymphocytic leukaemia recurrent 116.60 12.78 63 108316 2206 63378437
Small intestinal obstruction 116.41 12.78 150 108229 18187 63362456
Metastasis 115.98 12.78 85 108294 5112 63375531
Metastases to central nervous system 115.95 12.78 127 108252 12978 63367665
Irritable bowel syndrome 115.84 12.78 6 108373 82406 63298237
Haemophagocytic lymphohistiocytosis 115.56 12.78 115 108264 10512 63370131
Helicobacter infection 115.53 12.78 12 108367 92773 63287870
Blood pressure increased 114.84 12.78 67 108312 161995 63218648
B-cell lymphoma recurrent 114.22 12.78 38 108341 375 63380268
Overdose 114.03 12.78 28 108351 115050 63265593
White blood cell count decreased 111.58 12.78 502 107877 138602 63242041
Computerised tomogram thorax abnormal 110.74 12.78 56 108323 1707 63378936
Respiratory failure 109.88 12.78 403 107976 101455 63279188
Metastases to peritoneum 109.33 12.78 70 108309 3372 63377271
Neoplasm recurrence 105.10 12.78 62 108317 2576 63378067
Wheezing 103.42 12.78 19 108360 95576 63285067
Malaise 103.39 12.78 364 108015 415590 62965053
Skin toxicity 102.72 12.78 76 108303 4638 63376005
Neutrophil count abnormal 102.38 12.78 63 108316 2829 63377814
Premature menopause 99.13 12.78 42 108337 844 63379799
Agranulocytosis 98.88 12.78 164 108215 24970 63355673
Premature delivery 98.86 12.78 182 108197 30099 63350544
Confusional state 98.59 12.78 157 108222 236223 63144420
Bacteraemia 96.44 12.78 133 108246 17215 63363428
Stomatitis 94.80 12.78 478 107901 138247 63242396
Impaired healing 92.23 12.78 30 108349 102512 63278131
Bone marrow disorder 91.65 12.78 55 108324 2359 63378284
Osteoarthritis 91.01 12.78 25 108354 95318 63285325
Folliculitis 90.43 12.78 8 108371 70309 63310334
Intentional product misuse 90.40 12.78 3 108376 60914 63319729
Alopecia 90.25 12.78 286 108093 337250 63043393
Epstein-Barr virus infection 89.17 12.78 88 108291 7962 63372681
Lower respiratory tract infection 89.14 12.78 58 108321 132249 63248394
Lymphoma 89.07 12.78 107 108272 12080 63368563
Injection site erythema 88.97 12.78 17 108362 83157 63297486
Mobility decreased 88.83 12.78 48 108331 121111 63259532
Depression 87.24 12.78 125 108254 196367 63184276
Somnolence 87.17 12.78 106 108273 178579 63202064
Loss of personal independence in daily activities 86.56 12.78 29 108350 97261 63283382
Hypogammaglobulinaemia 84.48 12.78 81 108298 7074 63373569
Bronchitis 83.85 12.78 55 108324 124880 63255763
Hospitalisation 83.70 12.78 21 108358 85060 63295583
Venoocclusive liver disease 83.67 12.78 68 108311 4767 63375876
Condition aggravated 82.83 12.78 379 108000 401838 62978805
Drug resistance 81.45 12.78 143 108236 22790 63357853
Pericardial effusion 81.45 12.78 167 108212 29891 63350752
Smooth muscle cell neoplasm 81.43 12.78 36 108343 805 63379838
Diffuse large B-cell lymphoma 81.17 12.78 77 108302 6635 63374008
Myeloid leukaemia 80.83 12.78 29 108350 365 63380278
Gait disturbance 79.87 12.78 118 108261 183060 63197583
Gene mutation 79.39 12.78 44 108335 1621 63379022
Injury 78.28 12.78 15 108364 73232 63307411
Lymphopenia 78.09 12.78 124 108255 18203 63362440
Cystitis haemorrhagic 77.78 12.78 61 108318 4062 63376581
Ventricular hypokinesia 77.61 12.78 64 108315 4580 63376063
Ileus 77.55 12.78 110 108269 14615 63366028
Computerised tomogram thorax 77.14 12.78 29 108350 420 63380223
Abdominal pain upper 76.20 12.78 148 108231 206296 63174347
Cardiomyopathy acute 75.94 12.78 25 108354 238 63380405
Hypersensitivity 75.44 12.78 252 108127 292433 63088210
Bronchopulmonary aspergillosis 75.21 12.78 83 108296 8552 63372091
Intestinal perforation 74.59 12.78 97 108282 11866 63368777
Neutropenic infection 73.17 12.78 39 108340 1328 63379315
Drug abuse 73.09 12.78 17 108362 72501 63308142
Metastases to breast 72.07 12.78 25 108354 283 63380360
Varicella zoster virus infection 71.63 12.78 49 108330 2640 63378003
Atelectasis 71.23 12.78 130 108249 21353 63359290
Encephalopathy 70.85 12.78 184 108195 38436 63342207
Refractory anaemia with an excess of blasts 70.06 12.78 27 108352 420 63380223
Systemic candida 70.00 12.78 52 108327 3193 63377450
Leukaemia 68.26 12.78 57 108322 4151 63376492
Organising pneumonia 67.46 12.78 65 108314 5711 63374932
Cataract 67.00 12.78 9 108370 57044 63323599
Pneumatosis intestinalis 66.72 12.78 45 108334 2368 63378275
Blister 66.54 12.78 74 108305 129740 63250903
Treatment failure 66.48 12.78 151 108228 198892 63181751
Cytokine release syndrome 65.38 12.78 100 108279 14214 63366429
Injection site swelling 65.19 12.78 4 108375 47568 63333075
White blood cell count abnormal 65.03 12.78 66 108313 6176 63374467
Acute lymphocytic leukaemia 65.02 12.78 45 108334 2471 63378172
Fatigue 64.59 12.78 1098 107281 886930 62493713
Acquired gene mutation 64.02 12.78 32 108347 951 63379692
Cardiac dysfunction 63.60 12.78 43 108336 2272 63378371
Migraine 63.45 12.78 50 108329 103296 63277347
Thrombotic microangiopathy 63.31 12.78 84 108295 10477 63370166
Type 2 diabetes mellitus 62.36 12.78 16 108363 63852 63316791
Adverse drug reaction 62.30 12.78 29 108350 79685 63300958
Injection site pruritus 61.21 12.78 4 108375 45112 63335531
Metastases to spine 61.14 12.78 48 108331 3201 63377442
Vasogenic cerebral oedema 60.82 12.78 30 108349 866 63379777
Metastases to pleura 59.89 12.78 36 108343 1549 63379094
Pneumocystis jirovecii infection 59.44 12.78 35 108344 1449 63379194
JC virus infection 58.52 12.78 39 108340 2012 63378631
Acute hepatic failure 58.37 12.78 109 108270 18218 63362425
Suicide attempt 58.08 12.78 16 108363 60902 63319741
Peripheral motor neuropathy 57.93 12.78 36 108343 1645 63378998
Chemotherapy 57.43 12.78 35 108344 1544 63379099
Embolism 57.10 12.78 69 108310 7837 63372806
Lymphadenitis 56.55 12.78 46 108333 3229 63377414
Heart rate decreased 56.43 12.78 6 108373 45554 63335089
Memory impairment 56.14 12.78 57 108322 104201 63276442
Joint stiffness 55.96 12.78 4 108375 41865 63338778
Hypoxia 55.79 12.78 226 108153 59566 63321077
Metastases to skin 55.76 12.78 35 108344 1628 63379015
Salivary gland cancer 55.48 12.78 18 108361 163 63380480
C-reactive protein abnormal 54.78 12.78 7 108372 46089 63334554
Pulmonary embolism 54.77 12.78 364 108015 116320 63264323
Injection site reaction 54.63 12.78 16 108363 58508 63322135
Invasive ductal breast carcinoma 54.00 12.78 63 108316 6895 63373748
Capillary leak syndrome 53.71 12.78 38 108341 2162 63378481
Venoocclusive disease 53.63 12.78 37 108342 2021 63378622
Gastrosplenic fistula 53.42 12.78 14 108365 53 63380590
Nephrolithiasis 53.38 12.78 5 108374 41979 63338664
Injection site bruising 53.26 12.78 5 108374 41905 63338738
Nephropathy toxic 53.18 12.78 73 108306 9406 63371237
Cutaneous calcification 53.17 12.78 16 108363 110 63380533
Stress 53.16 12.78 24 108355 67143 63313500
Nasal congestion 52.70 12.78 23 108356 65637 63315006
Illness 52.52 12.78 10 108369 49049 63331594
Mantle cell lymphoma recurrent 52.03 12.78 18 108361 202 63380441
Gastrointestinal toxicity 51.78 12.78 65 108314 7676 63372967
Klebsiella infection 51.15 12.78 68 108311 8498 63372145
Alveolitis 50.45 12.78 41 108338 2874 63377769
Recurrent cancer 50.09 12.78 35 108344 1952 63378691
Suicidal ideation 49.88 12.78 22 108357 62399 63318244
Pulmonary alveolar haemorrhage 49.80 12.78 50 108329 4618 63376025
Enterococcal bacteraemia 49.66 12.78 31 108348 1428 63379215
Musculoskeletal pain 49.06 12.78 51 108328 92226 63288417
Ototoxicity 49.05 12.78 30 108349 1332 63379311
Ileus paralytic 49.02 12.78 49 108330 4502 63376141
Central nervous system lymphoma 48.83 12.78 31 108348 1471 63379172
Lymphoma transformation 48.82 12.78 16 108363 150 63380493
Cerebrovascular accident 48.63 12.78 68 108311 107956 63272687
Cytomegalovirus chorioretinitis 48.53 12.78 33 108346 1760 63378883
Haemoglobin abnormal 47.97 12.78 51 108328 5037 63375606
Balance disorder 47.96 12.78 44 108335 84378 63296265
5q minus syndrome 47.74 12.78 17 108362 209 63380434
Drug interaction 47.62 12.78 215 108164 228916 63151727
Pulmonary toxicity 47.40 12.78 69 108310 9386 63371257
Acute hepatitis B 47.38 12.78 19 108360 330 63380313
Cardiac failure acute 47.02 12.78 69 108310 9454 63371189
Extravasation 46.71 12.78 36 108343 2336 63378307
Fluid retention 46.19 12.78 22 108357 59664 63320979
Perineal infection 46.12 12.78 15 108364 137 63380506
Bursitis 45.56 12.78 5 108374 37036 63343607
Troponin increased 45.23 12.78 70 108309 10051 63370592
Palpitations 45.01 12.78 77 108302 112693 63267950
Hepatitis E 44.96 12.78 29 108350 1415 63379228
Philadelphia chromosome positive 44.61 12.78 19 108360 387 63380256
Perineal necrosis 44.57 12.78 14 108365 113 63380530
Inappropriate schedule of product administration 44.30 12.78 68 108311 103897 63276746
Hypertriglyceridaemia 44.18 12.78 54 108325 6205 63374438
Plasmacytoma 44.06 12.78 36 108343 2543 63378100
Gastrointestinal fungal infection 43.90 12.78 18 108361 332 63380311
Amnesia 43.77 12.78 20 108359 55565 63325078
Joint range of motion decreased 43.62 12.78 3 108376 32425 63348218
Plasma cell leukaemia 43.56 12.78 26 108353 1104 63379539
Ovarian cancer recurrent 43.42 12.78 25 108354 992 63379651
Visual impairment 43.41 12.78 48 108331 84398 63296245
Mitral valve incompetence 42.99 12.78 100 108279 19494 63361149
Clostridium difficile colitis 42.98 12.78 103 108276 20466 63360177
Hydrothorax 42.75 12.78 24 108355 907 63379736
Osteolysis 42.67 12.78 37 108342 2837 63377806
Alveolar soft part sarcoma 42.63 12.78 13 108366 94 63380549
Blood pressure fluctuation 42.62 12.78 13 108366 46304 63334339
Dry mouth 42.57 12.78 42 108337 77821 63302822
Myeloproliferative neoplasm 42.43 12.78 20 108359 521 63380122
Pseudomonal sepsis 42.04 12.78 34 108345 2367 63378276
Unintentional medical device removal 41.95 12.78 52 108327 6063 63374580
Blood glucose increased 41.55 12.78 49 108330 83707 63296936
Hyperferritinaemia 41.51 12.78 15 108364 193 63380450
Clonal evolution 41.41 12.78 12 108367 71 63380572
Hypoaesthesia 41.30 12.78 148 108231 168245 63212398
Sleep disorder 41.23 12.78 47 108332 81519 63299124
Tremor 41.21 12.78 104 108275 132135 63248508
Incorrect dose administered 40.76 12.78 26 108353 59942 63320701
Amenorrhoea 40.76 12.78 66 108313 9848 63370795
Blood pressure systolic increased 40.65 12.78 15 108364 47382 63333261
Synovial sarcoma 40.55 12.78 11 108368 49 63380594
Premature baby 40.32 12.78 101 108278 20634 63360009
Cardiogenic shock 39.87 12.78 92 108287 17840 63362803
T-cell type acute leukaemia 39.67 12.78 11 108368 54 63380589
Acute monocytic leukaemia 39.66 12.78 13 108366 122 63380521
Platelet count abnormal 39.56 12.78 38 108341 3326 63377317
Drug clearance decreased 39.43 12.78 27 108352 1457 63379186
Administration site extravasation 39.29 12.78 23 108356 942 63379701
Myelopathy 39.19 12.78 35 108344 2791 63377852
Squamous cell carcinoma of the oral cavity 38.98 12.78 16 108363 296 63380347
Hypertransaminasaemia 38.75 12.78 52 108327 6557 63374086
Secondary immunodeficiency 38.74 12.78 26 108353 1357 63379286
Primary cardiac lymphoma 38.52 12.78 9 108370 18 63380625
Blast cells present 38.43 12.78 18 108361 462 63380181
Ear infection 38.42 12.78 9 108370 38204 63342439
Device related infection 38.42 12.78 107 108272 23285 63357358
Neck pain 38.35 12.78 37 108342 69281 63311362
Colony stimulating factor therapy 38.25 12.78 16 108363 311 63380332
Angioedema 38.17 12.78 17 108362 47948 63332695
Enterococcal sepsis 38.15 12.78 26 108353 1392 63379251
Premature labour 38.12 12.78 73 108306 12431 63368212
Road traffic accident 38.10 12.78 8 108371 36624 63344019
Hepatic infarction 38.10 12.78 20 108359 660 63379983
Clostridium bacteraemia 37.93 12.78 14 108365 192 63380451
Vision blurred 37.39 12.78 62 108317 91862 63288781
Myasthenia gravis crisis 37.33 12.78 18 108361 494 63380149
Chest pain 37.29 12.78 216 108163 215743 63164900
Gastric disorder 37.18 12.78 9 108370 37360 63343283
Bone lesion 37.15 12.78 48 108331 5833 63374810
Epstein-Barr virus associated lymphoma 37.13 12.78 18 108361 500 63380143
Heart rate abnormal 37.08 12.78 44 108335 4903 63375740
Hypoglycaemia 36.94 12.78 29 108350 60036 63320607
Escherichia bacteraemia 36.75 12.78 39 108340 3844 63376799
Sciatica 36.73 12.78 7 108372 34317 63346326
Gastrooesophageal reflux disease 36.63 12.78 67 108312 95572 63285071
Prescribed underdose 36.53 12.78 4 108375 29685 63350958
Lung infiltration 36.43 12.78 78 108301 14385 63366258
Pyomyositis 36.14 12.78 16 108363 359 63380284
Osteoporosis 36.13 12.78 27 108352 57311 63323332
Amniotic fluid index decreased 36.10 12.78 8 108371 11 63380632
Therapy interrupted 36.08 12.78 6 108373 32449 63348194
Mucosal toxicity 35.98 12.78 16 108363 363 63380280
Flagellate dermatitis 35.92 12.78 13 108366 168 63380475
Inflammation 35.83 12.78 53 108326 82220 63298423
Ovarian epithelial cancer recurrent 35.69 12.78 8 108371 12 63380631
Mesenteric abscess 35.44 12.78 11 108368 85 63380558
Systolic dysfunction 35.34 12.78 26 108353 1573 63379070
Hyperpyrexia 35.30 12.78 37 108342 3595 63377048
Acute myelomonocytic leukaemia 35.11 12.78 13 108366 180 63380463
Radiation necrosis 35.00 12.78 16 108363 388 63380255
Drug ineffective 34.90 12.78 1445 106934 1043320 62337323
Onycholysis 34.80 12.78 26 108353 1610 63379033
Nasal abscess 34.72 12.78 13 108366 186 63380457
Infection reactivation 34.69 12.78 23 108356 1176 63379467
Gait inability 34.60 12.78 24 108355 52935 63327708
Humoral immune defect 34.51 12.78 14 108365 251 63380392
Loss of consciousness 34.45 12.78 96 108283 118025 63262618
Aplastic anaemia 34.41 12.78 60 108319 9509 63371134
Leukoencephalopathy 34.32 12.78 40 108339 4373 63376270
Rhabdomyolysis 34.32 12.78 16 108363 43935 63336708
Body dysmorphic disorder 34.19 12.78 15 108364 329 63380314
Osteomyelitis bacterial 34.10 12.78 13 108366 196 63380447
Cardiac ventricular thrombosis 34.09 12.78 18 108361 601 63380042
Peripartum cardiomyopathy 34.04 12.78 12 108367 143 63380500
Metastases to meninges 33.68 12.78 31 108348 2571 63378072
Necrotising gastritis 33.58 12.78 10 108369 66 63380577
Large intestinal ulcer perforation 33.45 12.78 10 108369 67 63380576
Swollen tongue 33.43 12.78 9 108370 34791 63345852
Hepatic failure 33.43 12.78 135 108244 35521 63345122
Respiratory syncytial virus infection 33.43 12.78 50 108329 6968 63373675
Toxic cardiomyopathy 33.38 12.78 12 108367 152 63380491
Staphylococcal sepsis 33.26 12.78 54 108325 8074 63372569
Traumatic lung injury 33.24 12.78 25 108354 1564 63379079
Myocardial infarction 33.15 12.78 76 108303 99817 63280826
Invasive lobular breast carcinoma 32.97 12.78 20 108359 875 63379768
Localised infection 32.67 12.78 6 108373 30204 63350439
Cardiac failure chronic 32.63 12.78 39 108340 4379 63376264
Limb injury 32.48 12.78 3 108376 25474 63355169
Cytomegalovirus viraemia 32.44 12.78 44 108335 5605 63375038
Leukoerythroblastosis 32.41 12.78 13 108366 226 63380417
Metastases to the mediastinum 32.12 12.78 16 108363 472 63380171
Pneumonia fungal 32.10 12.78 43 108336 5412 63375231
Klebsiella bacteraemia 32.03 12.78 25 108354 1653 63378990
Vocal cord paralysis 32.00 12.78 28 108351 2173 63378470
Maternal exposure during pregnancy 31.94 12.78 232 108147 219830 63160813
Limb discomfort 31.93 12.78 6 108373 29710 63350933
Enterococcal infection 31.93 12.78 52 108327 7796 63372847
Rhinovirus infection 31.85 12.78 39 108340 4490 63376153
Rash pruritic 31.84 12.78 33 108346 59766 63320877
Left ventricular dilatation 31.72 12.78 16 108363 485 63380158
Fanconi syndrome 31.59 12.78 23 108356 1369 63379274
Dry eye 31.58 12.78 15 108364 40746 63339897
Liver injury 31.55 12.78 34 108345 60486 63320157
Nail pigmentation 31.53 12.78 12 108367 180 63380463
Intertrigo 31.36 12.78 17 108362 599 63380044
Product quality issue 31.35 12.78 11 108368 35854 63344789
Aspergillus infection 30.75 12.78 52 108327 8041 63372602
Peripheral T-cell lymphoma unspecified 30.71 12.78 12 108367 194 63380449
B-cell lymphoma refractory 30.30 12.78 10 108369 96 63380547
Heart rate increased 30.23 12.78 73 108306 94165 63286478
Emotional distress 30.19 12.78 9 108370 32540 63348103
Therapeutic response delayed 30.17 12.78 17 108362 647 63379996
Unevaluable event 30.12 12.78 26 108353 51360 63329283
Adverse event 29.93 12.78 43 108336 67516 63313127
T-cell lymphoma 29.89 12.78 17 108362 659 63379984
Carbohydrate antigen 125 increased 29.74 12.78 30 108349 2786 63377857
Flatulence 29.73 12.78 11 108368 34691 63345952
Bone marrow infiltration 29.70 12.78 17 108362 667 63379976
Colitis 29.52 12.78 162 108217 48366 63332277
Hallucination 29.47 12.78 30 108349 54787 63325856
Clostridium difficile infection 29.43 12.78 115 108264 29807 63350836
Tumour marker increased 29.32 12.78 39 108340 4876 63375767
Intentional product use issue 29.01 12.78 116 108263 127776 63252867
Hyperhidrosis 29.01 12.78 91 108288 107745 63272898
Bicytopenia 28.90 12.78 28 108351 2477 63378166
Medication error 28.81 12.78 28 108351 52256 63328387
Chronic myeloid leukaemia 28.81 12.78 27 108352 2291 63378352
Acute leukaemia 28.64 12.78 20 108359 1114 63379529
Red blood cell sedimentation rate increased 28.64 12.78 20 108359 43962 63336681
Respiratory arrest 28.56 12.78 10 108369 32635 63348008
Thyroid dermatopathy 28.47 12.78 7 108372 19 63380624
Malignant transformation 28.42 12.78 14 108365 403 63380240
Quadriplegia 28.41 12.78 24 108355 1776 63378867
Hepatocellular injury 28.38 12.78 107 108272 27274 63353369
Cytogenetic abnormality 28.32 12.78 15 108364 504 63380139
Tissue infiltration 28.30 12.78 16 108363 613 63380030
Vena cava thrombosis 28.20 12.78 26 108353 2161 63378482
Ankle brachial index decreased 27.89 12.78 9 108370 80 63380563
Pulse waveform abnormal 27.89 12.78 9 108370 80 63380563
Klebsiella test positive 27.82 12.78 20 108359 1167 63379476
Leukaemic lymphoma 27.79 12.78 9 108370 81 63380562
Swelling face 27.53 12.78 41 108338 63434 63317209
Carotid intima-media thickness increased 27.50 12.78 9 108370 84 63380559
Basal ganglion degeneration 27.47 12.78 14 108365 434 63380209
Invasive breast carcinoma 27.38 12.78 16 108363 653 63379990
Febrile infection 27.16 12.78 22 108357 1535 63379108
Device pacing issue 27.13 12.78 9 108370 88 63380555
Cerebellar haemangioma 27.13 12.78 9 108370 88 63380555
Candida infection 27.11 12.78 108 108271 28243 63352400
Depressed level of consciousness 27.02 12.78 40 108339 62038 63318605
Influenza 27.01 12.78 95 108284 108627 63272016
Diarrhoea haemorrhagic 26.60 12.78 52 108327 8990 63371653
Acne 26.58 12.78 4 108375 23289 63357354
Periorbital cellulitis 26.44 12.78 16 108363 697 63379946
Bacterial sepsis 26.10 12.78 33 108346 3925 63376718
Multiple sclerosis 26.02 12.78 5 108374 24367 63356276
Death 25.94 12.78 829 107550 373552 63007091
Sinus polyp 25.84 12.78 13 108366 392 63380251
Light chain analysis increased 25.75 12.78 20 108359 1313 63379330
Chronic obstructive pulmonary disease 25.75 12.78 42 108337 62644 63317999
Treatment noncompliance 25.62 12.78 16 108363 37309 63343334
Urinary tract infection 25.52 12.78 309 108070 264375 63116268
Basal cell carcinoma 25.49 12.78 8 108371 27983 63352660
Drug reaction with eosinophilia and systemic symptoms 25.38 12.78 13 108366 33823 63346820
Infusion site streaking 25.38 12.78 14 108365 511 63380132
COVID-19 pneumonia 25.34 12.78 67 108312 14142 63366501
Seasonal allergy 25.33 12.78 3 108376 20947 63359696
Ventricular internal diameter abnormal 25.31 12.78 7 108372 34 63380609
Toxic neuropathy 25.16 12.78 13 108366 415 63380228
Granulomatous liver disease 25.15 12.78 16 108363 762 63379881
Dermatitis bullous 25.12 12.78 49 108330 8459 63372184
Clonal haematopoiesis 25.05 12.78 6 108373 14 63380629
Soft tissue neoplasm 24.80 12.78 8 108371 71 63380572
Lip swelling 24.73 12.78 11 108368 31052 63349591
Radiation skin injury 24.68 12.78 17 108362 926 63379717
Metastases to soft tissue 24.66 12.78 10 108369 179 63380464
Streptococcal bacteraemia 24.63 12.78 22 108357 1755 63378888
Cerebral venous sinus thrombosis 24.57 12.78 23 108356 1949 63378694
Hypoalbuminaemia 24.54 12.78 59 108320 11746 63368897
Cytomegalovirus infection reactivation 24.50 12.78 32 108347 3931 63376712
Tumour necrosis 24.40 12.78 16 108363 803 63379840
Ventricular dysfunction 24.31 12.78 27 108352 2801 63377842
Carbohydrate antigen 15-3 increased 24.29 12.78 20 108359 1428 63379215
International normalised ratio increased 24.29 12.78 26 108353 46399 63334244
Sinus disorder 24.26 12.78 6 108373 24547 63356096
Myocarditis 24.09 12.78 54 108325 10271 63370372
Large intestine perforation 24.01 12.78 48 108331 8434 63372209
Primary immunodeficiency syndrome 23.93 12.78 7 108372 43 63380600
Abdominal compartment syndrome 23.79 12.78 14 108365 579 63380064
Deep vein thrombosis 23.76 12.78 233 108146 83567 63297076
Eosinophilia 23.60 12.78 5 108374 22751 63357892
Acute respiratory distress syndrome 23.59 12.78 91 108288 23443 63357200
Toxic erythema of chemotherapy 23.59 12.78 9 108370 136 63380507
Immune effector cell-associated neurotoxicity syndrome 23.58 12.78 24 108355 2253 63378390
Mediastinitis 23.55 12.78 10 108369 202 63380441
Small intestinal perforation 23.50 12.78 20 108359 1495 63379148
Listeria sepsis 23.47 12.78 15 108364 720 63379923
Cerebellar stroke 23.46 12.78 11 108368 283 63380360
Device electrical impedance issue 23.42 12.78 5 108374 5 63380638
Increased liver stiffness 23.42 12.78 5 108374 5 63380638
Refractory cytopenia with multilineage dysplasia 23.41 12.78 9 108370 139 63380504
Eye swelling 23.33 12.78 6 108373 23912 63356731
Fungal oesophagitis 23.31 12.78 15 108364 729 63379914
Intussusception 23.25 12.78 14 108365 604 63380039
Nodular regenerative hyperplasia 23.11 12.78 13 108366 493 63380150
Nervousness 23.09 12.78 12 108367 30967 63349676
Product prescribing error 23.09 12.78 8 108371 26281 63354362
Left atrial enlargement 22.98 12.78 11 108368 297 63380346
Cardio-respiratory arrest 22.96 12.78 42 108337 59917 63320726
PIK3CA-activated mutation 22.91 12.78 17 108362 1042 63379601
Acute pulmonary oedema 22.90 12.78 46 108333 8112 63372531
Influenza like illness 22.85 12.78 50 108329 66774 63313869
Oedema peripheral 22.82 12.78 210 108169 189301 63191342
Disseminated intravascular coagulation 22.77 12.78 78 108301 18973 63361670
Lymphadenopathy mediastinal 22.76 12.78 26 108353 2782 63377861
Eye pain 22.57 12.78 15 108364 33839 63346804
Strongyloidiasis 22.55 12.78 18 108361 1230 63379413
Proteinuria 22.54 12.78 78 108301 19067 63361576
Oophoritis 22.49 12.78 8 108371 98 63380545
Hip arthroplasty 22.44 12.78 29 108350 47617 63333026
Inflammatory myofibroblastic tumour 22.44 12.78 6 108373 25 63380618
Liver abscess 22.41 12.78 26 108353 2828 63377815
Brain oedema 22.40 12.78 64 108315 14131 63366512
Pregnancy 22.38 12.78 18 108361 36818 63343825
Uterine enlargement 22.29 12.78 18 108361 1250 63379393
Drug dependence 22.29 12.78 7 108372 24476 63356167
Hepatotoxicity 22.09 12.78 123 108256 36918 63343725
Pharyngeal inflammation 21.98 12.78 14 108365 668 63379975
Dementia 21.98 12.78 3 108376 18791 63361852
Chronic myelomonocytic leukaemia 21.97 12.78 11 108368 328 63380315
Mass 21.97 12.78 63 108316 13937 63366706
Combined immunodeficiency 21.86 12.78 8 108371 107 63380536
Exposure during pregnancy 21.80 12.78 380 107999 155167 63225476
Neurological symptom 21.76 12.78 37 108342 5746 63374897
Central nervous system enteroviral infection 21.72 12.78 6 108373 29 63380614
Subdural hygroma 21.70 12.78 10 108369 247 63380396
Abdominal neoplasm 21.64 12.78 11 108368 339 63380304
Joint neoplasm 21.61 12.78 7 108372 63 63380580
Serotonin syndrome 21.54 12.78 11 108368 28671 63351972
Epstein-Barr virus associated lymphoproliferative disorder 21.53 12.78 21 108358 1873 63378770
Pseudocirrhosis 21.52 12.78 14 108365 693 63379950
Hypercholesterolaemia 21.50 12.78 5 108374 21329 63359314
Dysaesthesia 21.46 12.78 32 108347 4446 63376197
Metastases to bone marrow 21.46 12.78 12 108367 450 63380193
Amputation stump pain 21.39 12.78 6 108373 31 63380612
Hypokalaemia 21.37 12.78 271 108108 103533 63277110
Splenomegaly 21.33 12.78 54 108325 11103 63369540
Atrial fibrillation 21.32 12.78 298 108081 116338 63264305
Oedema 21.23 12.78 90 108289 97532 63283111
Metastases to chest wall 21.20 12.78 13 108366 580 63380063
Encephalitis viral 21.19 12.78 20 108359 1712 63378931
Geotrichum infection 21.17 12.78 12 108367 462 63380181
Heart rate irregular 21.16 12.78 6 108373 22415 63358228
Colitis ulcerative 21.15 12.78 9 108370 26082 63354561
Blood pressure decreased 21.14 12.78 50 108329 64972 63315671
Anastomotic leak 21.10 12.78 12 108367 465 63380178
Respiratory distress 21.09 12.78 114 108265 33837 63346806
Acute erythroid leukaemia 21.05 12.78 7 108372 69 63380574
Gastric stenosis 21.05 12.78 7 108372 69 63380574
Hepatic lesion 21.04 12.78 33 108346 4792 63375851
Panic attack 21.03 12.78 6 108373 22325 63358318
Agitation 21.03 12.78 44 108335 59713 63320930
Grip strength decreased 20.97 12.78 6 108373 22281 63358362
Blood lactate dehydrogenase abnormal 20.92 12.78 11 108368 364 63380279
Joint ankylosis 20.87 12.78 16 108363 1030 63379613
Rhinorrhoea 20.87 12.78 51 108328 65526 63315117
Hyperbilirubinaemia 20.84 12.78 54 108325 11260 63369383
Ovarian cancer metastatic 20.76 12.78 15 108364 882 63379761
Acute biphenotypic leukaemia 20.70 12.78 7 108372 73 63380570
Accidental overdose 20.63 12.78 7 108372 23302 63357341
Eczema 20.61 12.78 15 108364 32276 63348367
Diabetes mellitus 20.57 12.78 40 108339 55770 63324873
Eye irritation 20.51 12.78 6 108373 21965 63358678
Foetal growth restriction 20.50 12.78 42 108337 7511 63373132
Lymphocyte count decreased 20.45 12.78 104 108275 30153 63350490
Kidney infection 20.44 12.78 7 108372 23169 63357474
Mantle cell lymphoma 20.44 12.78 12 108367 494 63380149
Eastern Cooperative Oncology Group performance status worsened 20.37 12.78 17 108362 1237 63379406
Metastases to pancreas 20.36 12.78 10 108369 286 63380357
Nightmare 20.36 12.78 4 108375 19190 63361453
Blood magnesium decreased 20.34 12.78 59 108320 13139 63367504
Paraparesis 20.26 12.78 22 108357 2226 63378417
Subileus 20.16 12.78 26 108353 3153 63377490
Pleural disorder 20.16 12.78 13 108366 634 63380009
Pulmonary vein stenosis 20.04 12.78 7 108372 81 63380562
Mucoepidermoid carcinoma 19.97 12.78 6 108373 41 63380602
Glaucoma 19.92 12.78 4 108375 18901 63361742
Cardiac tamponade 19.92 12.78 32 108347 4743 63375900
Systemic toxicity 19.89 12.78 7 108372 83 63380560
Irritability 19.87 12.78 15 108364 31679 63348964
Lipidosis 19.84 12.78 6 108373 42 63380601
Gallbladder disorder 19.83 12.78 4 108375 18838 63361805
Abdominal abscess 19.80 12.78 31 108348 4495 63376148
Injection site rash 19.78 12.78 4 108375 18805 63361838
Joint dislocation 19.77 12.78 4 108375 18796 63361847
Lymphocytosis 19.74 12.78 24 108355 2743 63377900
Transaminases 19.74 12.78 7 108372 85 63380558
Hip fracture 19.73 12.78 13 108366 29461 63351182
Jejunal stenosis 19.72 12.78 6 108373 43 63380600
Duodenal stenosis 19.68 12.78 12 108367 530 63380113
Granulocytopenia 19.66 12.78 35 108344 5637 63375006
Therapy cessation 19.63 12.78 14 108365 30443 63350200
Ovarian cancer 19.60 12.78 36 108343 5940 63374703
Left ventricular failure 19.60 12.78 35 108344 5652 63374991
Intervertebral disc protrusion 19.51 12.78 8 108371 23701 63356942
Malnutrition 19.49 12.78 64 108315 15234 63365409
Platelet disorder 19.49 12.78 20 108359 1896 63378747
Poor quality sleep 19.45 12.78 5 108374 19930 63360713
Opsoclonus myoclonus 19.44 12.78 8 108371 149 63380494
Tooth disorder 19.42 12.78 12 108367 28145 63352498
Lactic acidosis 19.41 12.78 22 108357 38265 63342378
Follicular lymphoma 19.40 12.78 9 108370 226 63380417
Anaesthesia 19.39 12.78 11 108368 424 63380219
Renal tubular dysfunction 19.39 12.78 11 108368 424 63380219
Post-acute COVID-19 syndrome 19.37 12.78 11 108368 425 63380218
Dysstasia 19.36 12.78 6 108373 21160 63359483
BRCA2 gene mutation 19.31 12.78 7 108372 91 63380552
Muscular weakness 19.22 12.78 126 108253 122227 63258416
Necrosis 19.20 12.78 34 108345 5453 63375190
Oligohydramnios 19.20 12.78 37 108342 6329 63374314
Non-cirrhotic portal hypertension 19.18 12.78 9 108370 232 63380411
Peritonitis viral 19.15 12.78 6 108373 48 63380595
Vulvovaginitis 19.13 12.78 10 108369 327 63380316
Liver function test abnormal 19.12 12.78 33 108346 48148 63332495
Epstein Barr virus positive mucocutaneous ulcer 19.12 12.78 11 108368 436 63380207
Device dislocation 19.10 12.78 10 108369 25695 63354948
Mucormycosis 19.03 12.78 24 108355 2847 63377796
Tendonitis 18.98 12.78 5 108374 19610 63361033
Neoplasm 18.95 12.78 40 108339 7305 63373338
Renal disorder 18.94 12.78 17 108362 32957 63347686
Sneezing 18.90 12.78 4 108375 18214 63362429
Fasciitis 18.89 12.78 12 108367 570 63380073
Carpal tunnel syndrome 18.87 12.78 6 108373 20811 63359832
Transient ischaemic attack 18.81 12.78 22 108357 37731 63342912
Leukoplakia oral 18.78 12.78 8 108371 163 63380480
Metastases to abdominal cavity 18.78 12.78 11 108368 451 63380192
Enterocutaneous fistula 18.78 12.78 17 108362 1380 63379263
Neonatal lupus erythematosus 18.73 12.78 4 108375 4 63380639
Osteosarcoma metastatic 18.67 12.78 5 108374 21 63380622
Paranasal sinus mucosal hypertrophy 18.67 12.78 5 108374 21 63380622
Chromosomal deletion 18.58 12.78 7 108372 102 63380541
Chronic hepatitis 18.53 12.78 14 108365 882 63379761
Breast oedema 18.53 12.78 6 108373 54 63380589
Mitral valve disease 18.49 12.78 22 108357 2458 63378185
Metastatic lymphoma 18.47 12.78 8 108371 170 63380473
Leukaemia cutis 18.46 12.78 7 108372 104 63380539
Breast neoplasm 18.42 12.78 17 108362 1415 63379228
Pseudomonal bacteraemia 18.41 12.78 18 108361 1610 63379033
Malignant ascites 18.39 12.78 14 108365 892 63379751
Respiratory tract congestion 18.33 12.78 4 108375 17828 63362815
Heavy menstrual bleeding 18.24 12.78 4 108375 17769 63362874
Enterocolitis 18.23 12.78 41 108338 7817 63372826
Pleuroparenchymal fibroelastosis 18.16 12.78 7 108372 109 63380534
Venous thrombosis limb 18.15 12.78 24 108355 2984 63377659
Enterocolitis infectious 18.13 12.78 18 108361 1640 63379003
HER2 positive breast cancer 18.10 12.78 10 108369 366 63380277
Dysplasia 18.06 12.78 14 108365 916 63379727
Ear pain 18.05 12.78 21 108358 36097 63344546
BK virus infection 18.01 12.78 25 108354 3254 63377389
Transaminases increased 17.94 12.78 103 108276 31264 63349379
Rash erythematous 17.91 12.78 28 108351 42482 63338161
Alopecia areata 17.89 12.78 18 108361 1667 63378976
Lymphangioleiomyomatosis 17.89 12.78 8 108371 184 63380459
Human rhinovirus test positive 17.85 12.78 8 108371 185 63380458
Feeling hot 17.78 12.78 37 108342 50317 63330326
Aggression 17.67 12.78 9 108370 23489 63357154
Urethritis 17.66 12.78 9 108370 279 63380364
Artificial menopause 17.64 12.78 5 108374 27 63380616
Oral fungal infection 17.63 12.78 24 108355 3067 63377576
Secondary cerebellar degeneration 17.62 12.78 6 108373 64 63380579
Liver function test increased 17.58 12.78 18 108361 32793 63347850
Burning sensation 17.56 12.78 42 108337 54365 63326278
Primary mediastinal large B-cell lymphoma recurrent 17.53 12.78 6 108373 65 63380578
Cholelithiasis 17.51 12.78 30 108349 43895 63336748
Reproductive toxicity 17.46 12.78 4 108375 7 63380636
Low birth weight baby 17.44 12.78 38 108341 7091 63373552
Atrial flutter 17.35 12.78 46 108333 9726 63370917
Pulmonary haemorrhage 17.25 12.78 38 108341 7143 63373500
Herpes zoster meningoencephalitis 17.20 12.78 9 108370 295 63380348
Failure to thrive 17.19 12.78 38 108341 7160 63373483
Joint effusion 17.18 12.78 4 108375 17056 63363587
Head injury 17.13 12.78 13 108366 27383 63353260
Hormone receptor positive breast cancer 17.12 12.78 11 108368 533 63380110
Vulvovaginal inflammation 17.11 12.78 13 108366 826 63379817
Coronary artery disease 17.08 12.78 18 108361 32359 63348284
Mediastinum neoplasm 17.06 12.78 6 108373 71 63380572
Frequent bowel movements 17.04 12.78 9 108370 23013 63357630
Orthostatic hypotension 17.04 12.78 22 108357 36138 63344505
Breast cancer 17.02 12.78 141 108238 48242 63332401
Mood swings 17.01 12.78 5 108374 18243 63362400
Pneumonia 16.91 12.78 947 107432 455820 62924823
IIIrd nerve paralysis 16.91 12.78 12 108367 686 63379957
Metastatic neoplasm 16.85 12.78 28 108351 4267 63376376
Lymph node fibrosis 16.80 12.78 4 108375 9 63380634
Ventricular remodelling 16.80 12.78 4 108375 9 63380634
Hydronephrosis 16.75 12.78 48 108331 10614 63370029
Right ventricular dysfunction 16.74 12.78 18 108361 1801 63378842
Movement disorder 16.73 12.78 8 108371 21653 63358990
Duodenal perforation 16.73 12.78 13 108366 854 63379789
Intestinal obstruction 16.72 12.78 100 108279 30799 63349844
Stem cell transplant 16.71 12.78 18 108361 1804 63378839
Jejunal ulcer perforation 16.54 12.78 5 108374 35 63380608
Trichodysplasia spinulosa 16.53 12.78 11 108368 566 63380077
Gastroenteritis viral 16.49 12.78 10 108369 23690 63356953
VIth nerve paresis 16.48 12.78 6 108373 79 63380564
Abnormal behaviour 16.42 12.78 8 108371 21418 63359225
Triple negative breast cancer 16.41 12.78 7 108372 143 63380500
Therapy non-responder 16.41 12.78 200 108179 75701 63304942
Splenic marginal zone lymphoma 16.41 12.78 5 108374 36 63380607
Acute hepatitis C 16.41 12.78 6 108373 80 63380563
Diabetes mellitus inadequate control 16.37 12.78 3 108376 15123 63365520
Weight decreased 16.35 12.78 354 108025 276444 63104199
Atypical haemolytic uraemic syndrome 16.35 12.78 12 108367 723 63379920
Obliterative bronchiolitis 16.31 12.78 19 108360 2076 63378567
Upper limb fracture 16.27 12.78 6 108373 18962 63361681
Pseudomonas infection 16.20 12.78 49 108330 11164 63369479
Aortitis 16.15 12.78 14 108365 1073 63379570
Sputum discoloured 16.14 12.78 4 108375 16343 63364300
Mucoepidermoid carcinoma of salivary gland 16.12 12.78 3 108376 0 63380643
Meningitis streptococcal 16.11 12.78 7 108372 150 63380493
Necrotising colitis 16.09 12.78 11 108368 592 63380051
Creatinine renal clearance decreased 16.08 12.78 4 108375 16304 63364339
Blood stem cell transplant failure 16.06 12.78 7 108372 151 63380492
Orthopnoea 16.04 12.78 34 108345 6227 63374416
Pneumonia influenzal 15.98 12.78 17 108362 1680 63378963
Oesophageal candidiasis 15.97 12.78 32 108347 5631 63375012
Infusion site joint movement impairment 15.97 12.78 4 108375 12 63380631
Cytology abnormal 15.97 12.78 4 108375 12 63380631
Enterovirus test positive 15.90 12.78 7 108372 155 63380488
Lymphoedema 15.88 12.78 50 108329 11642 63369001
Tricuspid valve incompetence 15.87 12.78 58 108321 14563 63366080
Chronic hepatitis B 15.84 12.78 9 108370 348 63380295
Neurological decompensation 15.84 12.78 21 108358 2617 63378026
Metastases to retroperitoneum 15.81 12.78 7 108372 157 63380486
Mucosal erosion 15.74 12.78 16 108363 1500 63379143
Acral peeling skin syndrome 15.73 12.78 4 108375 13 63380630
B-cell aplasia 15.71 12.78 6 108373 91 63380552
Infusion related reaction 15.68 12.78 310 108069 245211 63135432
Restless legs syndrome 15.66 12.78 6 108373 18525 63362118
Faeces discoloured 15.63 12.78 6 108373 18503 63362140
Ill-defined disorder 15.62 12.78 79 108300 81676 63298967
Sleep apnoea syndrome 15.59 12.78 16 108363 29117 63351526
Paraesthesia 15.59 12.78 182 108197 156784 63223859
Myasthenic syndrome 15.58 12.78 8 108371 252 63380391
Renal tubular disorder 15.57 12.78 21 108358 2661 63377982
General physical health deterioration 15.53 12.78 452 107927 200950 63179693
Blood pressure diastolic abnormal 15.49 12.78 3 108376 14539 63366104
Pneumonia cytomegaloviral 15.46 12.78 19 108360 2195 63378448
Listeria encephalitis 15.46 12.78 8 108371 256 63380387
Antithrombin III decreased 15.43 12.78 8 108371 257 63380386
Gastrointestinal perforation 15.40 12.78 24 108355 3467 63377176
Hepatomegaly 15.38 12.78 50 108329 11839 63368804
Syphilis 15.38 12.78 7 108372 168 63380475
Pyloric stenosis 15.36 12.78 9 108370 369 63380274
Cancer in remission 15.34 12.78 5 108374 46 63380597
Laboratory test abnormal 15.31 12.78 14 108365 26898 63353745
Disturbance in attention 15.30 12.78 26 108353 38163 63342480
Leiomyosarcoma metastatic 15.29 12.78 4 108375 15 63380628
Upper respiratory tract infection 15.27 12.78 80 108299 81967 63298676
Salmonella sepsis 15.27 12.78 8 108371 263 63380380
Genital infection 15.26 12.78 7 108372 171 63380472
Haemorrhage intracranial 15.22 12.78 54 108325 13365 63367278
Blood pressure diastolic decreased 15.22 12.78 10 108369 22696 63357947
Thrombophlebitis 15.20 12.78 27 108352 4341 63376302
Diarrhoea 15.13 12.78 1035 107344 714331 62666312
Portal hypertension 15.12 12.78 25 108354 3794 63376849
Beta 2 microglobulin decreased 15.09 12.78 4 108375 16 63380627
Angioimmunoblastic T-cell lymphoma 15.08 12.78 6 108373 102 63380541
Muscle necrosis 15.07 12.78 11 108368 657 63379986
Rectal fissure 15.04 12.78 11 108368 659 63379984
Cerebral haemangioma 15.03 12.78 6 108373 103 63380540
Hypersomnia 15.01 12.78 6 108373 18049 63362594
Constipation 15.00 12.78 496 107883 224447 63156196
Ovarian cancer stage IV 14.99 12.78 8 108371 273 63380370
Tachycardia induced cardiomyopathy 14.92 12.78 6 108373 105 63380538
Metastases to vagina 14.90 12.78 4 108375 17 63380626
Vomiting 14.89 12.78 1128 107251 558489 62822154
Diverticulitis 14.88 12.78 28 108351 39529 63341114
Inappropriate antidiuretic hormone secretion 14.86 12.78 59 108320 15403 63365240
Rhabdomyosarcoma 14.82 12.78 6 108373 107 63380536
Pulmonary mass 14.81 12.78 77 108302 22519 63358124
Blood uric acid increased 14.75 12.78 30 108349 5337 63375306
Throat irritation 14.74 12.78 26 108353 37621 63343022
Blood potassium decreased 14.74 12.78 31 108348 41995 63338648
Marginal zone lymphoma recurrent 14.71 12.78 4 108375 18 63380625
Dry skin 14.60 12.78 49 108330 56838 63323805
Jugular vein thrombosis 14.54 12.78 22 108357 3096 63377547
Pulmonary artery stenosis 14.52 12.78 7 108372 192 63380451
Hypoglossal nerve paresis 14.52 12.78 6 108373 113 63380530
Subclavian vein thrombosis 14.48 12.78 17 108362 1873 63378770
Low cardiac output syndrome 14.47 12.78 9 108370 412 63380231
Malignant neoplasm of orbit 14.37 12.78 4 108375 20 63380623
Ulcer 14.36 12.78 14 108365 26093 63354550
Clostridium colitis 14.31 12.78 17 108362 1897 63378746
Hypersensitivity pneumonitis 14.25 12.78 20 108359 2630 63378013
Blood disorder 14.25 12.78 34 108345 6737 63373906
Fungaemia 14.23 12.78 19 108360 2384 63378259
Ocular lymphoma 14.23 12.78 5 108374 59 63380584
Tumour ulceration 14.23 12.78 7 108372 201 63380442
Non-cardiogenic pulmonary oedema 14.19 12.78 11 108368 720 63379923
Venous thrombosis 14.19 12.78 28 108351 4874 63375769
Retroperitoneal mass 14.19 12.78 6 108373 120 63380523
Photosensitivity reaction 14.17 12.78 4 108375 14990 63365653
Lymphoproliferative disorder 14.16 12.78 22 108357 3168 63377475
Granulomatous pneumonitis 14.15 12.78 5 108374 60 63380583
Sinus tachycardia 14.08 12.78 80 108299 24188 63356455
B-lymphocyte count abnormal 14.08 12.78 5 108374 61 63380582
Wrist fracture 14.06 12.78 3 108376 13584 63367059
Peripheral sensorimotor neuropathy 14.05 12.78 15 108364 1488 63379155
Chondrosarcoma metastatic 14.05 12.78 3 108376 3 63380640
Abortion spontaneous 14.02 12.78 38 108341 47157 63333486
Musculoskeletal disorder 13.96 12.78 9 108370 20635 63360008
Vessel puncture site bruise 13.92 12.78 9 108370 441 63380202
Poor venous access 13.87 12.78 4 108375 14781 63365862
Live birth 13.80 12.78 14 108365 25616 63355027
Toxic encephalopathy 13.80 12.78 33 108346 6546 63374097
Infusion site necrosis 13.79 12.78 5 108374 65 63380578
Vertigo 13.78 12.78 54 108325 59833 63320810
Metastases to ovary 13.77 12.78 9 108370 449 63380194
Skin mass 13.73 12.78 31 108348 5924 63374719
Haematoma 13.68 12.78 24 108355 34796 63345847
Osteonecrosis 13.67 12.78 80 108299 24450 63356193
Leukaemia recurrent 13.67 12.78 14 108365 1324 63379319
Adenovirus infection 13.64 12.78 23 108356 3548 63377095
Bone density decreased 13.62 12.78 4 108375 14608 63366035
Mediastinal fibrosis 13.62 12.78 4 108375 25 63380618
Infusion site ulcer 13.62 12.78 4 108375 25 63380618
B-cell lymphoma 13.58 12.78 22 108357 3283 63377360
Chemotherapeutic drug level increased 13.54 12.78 6 108373 135 63380508
Sinus congestion 13.54 12.78 7 108372 18116 63362527
Laryngitis 13.52 12.78 6 108373 16961 63363682
Metastases to stomach 13.50 12.78 7 108372 225 63380418
Corneal graft rejection 13.48 12.78 4 108375 26 63380617
Rosai-Dorfman syndrome 13.48 12.78 4 108375 26 63380617
B precursor type acute leukaemia 13.47 12.78 7 108372 226 63380417
Hepatitis C RNA increased 13.46 12.78 6 108373 137 63380506
Crying 13.45 12.78 12 108367 23331 63357312
Infusion site hypoaesthesia 13.35 12.78 4 108375 27 63380616
Hypofibrinogenaemia 13.35 12.78 13 108366 1157 63379486
Arrhythmia 13.34 12.78 111 108268 38029 63342614
Immune-mediated hypophysitis 13.33 12.78 5 108374 72 63380571
Bradycardia 13.30 12.78 72 108307 73155 63307488
Full blood count abnormal 13.26 12.78 21 108358 31696 63348947
Thrombocytopenic purpura 13.22 12.78 14 108365 1377 63379266
Hypercalcaemia 13.06 12.78 88 108291 28234 63352409
Deafness 13.04 12.78 63 108316 17894 63362749
Impaired fasting glucose 13.04 12.78 7 108372 242 63380401
Peritoneal disorder 13.02 12.78 9 108370 493 63380150
Lung adenocarcinoma 13.00 12.78 26 108353 4571 63376072
Hepatic calcification 12.99 12.78 4 108375 30 63380613
Scintillating scotoma 12.96 12.78 6 108373 150 63380493
Pleural neoplasm 12.92 12.78 8 108371 363 63380280
Ligament sprain 12.90 12.78 3 108376 12797 63367846
Cyst 12.89 12.78 4 108375 14095 63366548
Osteopenia 12.88 12.78 9 108370 19776 63360867
Femur fracture 12.87 12.78 33 108346 41723 63338920
Squamous cell carcinoma of the tongue 12.84 12.78 8 108371 367 63380276
Acute lymphocytic leukaemia refractory 12.84 12.78 5 108374 80 63380563
Coronary ostial stenosis 12.84 12.78 5 108374 80 63380563
Cerebellar mutism 12.84 12.78 3 108376 6 63380637
Lymph node pain 12.83 12.78 14 108365 1424 63379219
Soft tissue infection 12.81 12.78 17 108362 2120 63378523
Muscle spasticity 12.80 12.78 11 108368 21783 63358860

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3905.61 14.22 2963 81537 133886 34738545
Disease progression 1427.40 14.22 1520 82980 106557 34765874
Neutropenia 1342.36 14.22 1766 82734 155012 34717419
Off label use 976.22 14.22 2701 81799 416823 34455608
Product use in unapproved indication 840.11 14.22 1215 83285 116284 34756147
Diffuse large B-cell lymphoma recurrent 719.99 14.22 277 84223 2951 34869480
Mucosal inflammation 708.48 14.22 651 83849 37971 34834460
Haematotoxicity 621.50 14.22 331 84169 7863 34864568
Second primary malignancy 596.55 14.22 318 84182 7568 34864863
Hepatitis B 570.53 14.22 282 84218 5701 34866730
Myelosuppression 568.82 14.22 428 84072 18837 34853594
Cardiotoxicity 537.93 14.22 266 84234 5382 34867049
Hepatitis B reactivation 521.36 14.22 232 84268 3659 34868772
Myelodysplastic syndrome 468.04 14.22 381 84119 18827 34853604
Acute myeloid leukaemia 467.67 14.22 373 84127 17897 34854534
Tumour lysis syndrome 423.27 14.22 342 84158 16717 34855714
Bone marrow failure 399.72 14.22 420 84080 28833 34843598
Pancytopenia 396.96 14.22 774 83726 94383 34778048
Therapy partial responder 379.34 14.22 255 84245 9361 34863070
Thrombocytopenia 341.98 14.22 988 83512 155259 34717172
Neoplasm progression 304.91 14.22 327 84173 22973 34849458
Neutropenic sepsis 281.66 14.22 247 84253 13520 34858911
Febrile bone marrow aplasia 277.51 14.22 198 84302 8011 34864420
Cytopenia 273.88 14.22 235 84265 12488 34859943
Progressive multifocal leukoencephalopathy 261.94 14.22 205 84295 9559 34862872
Diffuse large B-cell lymphoma refractory 255.28 14.22 101 84399 1165 34871266
Pneumocystis jirovecii pneumonia 246.30 14.22 270 84230 19440 34852991
Product dose omission issue 242.86 14.22 11 84489 119700 34752731
Leukopenia 236.37 14.22 490 84010 62366 34810065
Neutrophil count decreased 231.68 14.22 431 84069 50673 34821758
Fall 222.93 14.22 106 84394 202779 34669652
Cytomegalovirus chorioretinitis 217.23 14.22 125 84375 3464 34868967
Acquired gene mutation 211.52 14.22 90 84410 1265 34871166
B-cell lymphoma recurrent 197.30 14.22 74 84426 730 34871701
Neuropathy peripheral 191.93 14.22 537 83963 82726 34789705
Mantle cell lymphoma recurrent 190.06 14.22 71 84429 692 34871739
Septic shock 188.42 14.22 486 84014 71348 34801083
Pyrexia 186.38 14.22 1408 83092 331605 34540826
Malignant neoplasm progression 175.31 14.22 539 83961 87507 34784924
Disease recurrence 174.88 14.22 237 84263 21253 34851178
Hypogammaglobulinaemia 168.67 14.22 144 84356 7596 34864835
Lymphadenopathy 168.18 14.22 270 84230 28193 34844238
Rash 164.19 14.22 178 84322 222574 34649857
Arthralgia 163.30 14.22 105 84395 169936 34702495
Sepsis 161.95 14.22 813 83687 165748 34706683
Posterior reversible encephalopathy syndrome 159.77 14.22 156 84344 9798 34862633
Dizziness 158.43 14.22 177 84323 218344 34654087
Cardiomyopathy 157.95 14.22 199 84301 16609 34855822
Myocardial infarction 149.47 14.22 53 84447 121032 34751399
Diffuse large B-cell lymphoma 144.28 14.22 129 84371 7241 34865190
Anxiety 144.08 14.22 32 84468 99396 34773035
Polyneuropathy 142.58 14.22 178 84322 14718 34857713
Blood lactate dehydrogenase increased 132.96 14.22 216 84284 22774 34849657
Pruritus 129.14 14.22 93 84407 141888 34730543
Cytokine release syndrome 124.32 14.22 209 84291 22668 34849763
Muscle spasms 124.22 14.22 17 84483 74984 34797447
Somnolence 123.50 14.22 57 84443 111059 34761372
Drug interaction 122.25 14.22 225 84275 225721 34646710
Lymphoma 120.57 14.22 150 84350 12357 34860074
Rhabdomyolysis 118.89 14.22 13 84487 68150 34804281
Weight increased 117.76 14.22 39 84461 92994 34779437
Blood pressure increased 116.77 14.22 34 84466 88068 34784363
Cytomegalovirus infection 116.57 14.22 219 84281 25916 34846515
Fatigue 113.69 14.22 486 84014 370167 34502264
Neoplasm recurrence 111.79 14.22 69 84431 2180 34870251
Cystitis haemorrhagic 110.37 14.22 99 84401 5580 34866851
Joint swelling 108.15 14.22 10 84490 59880 34812551
Feeling abnormal 107.93 14.22 13 84487 63222 34809209
Dyspnoea 107.17 14.22 508 83992 376274 34496157
Candida infection 105.93 14.22 169 84331 17546 34854885
Ejection fraction decreased 105.42 14.22 176 84324 18978 34853453
Anaemia 105.00 14.22 940 83560 232395 34640036
Depression 104.54 14.22 52 84448 97046 34775385
Death 104.47 14.22 552 83948 397497 34474934
Pain 104.42 14.22 211 84289 204464 34667967
Insomnia 104.05 14.22 61 84439 103846 34768585
Headache 103.06 14.22 206 84294 200429 34672002
Sweat gland tumour 102.63 14.22 39 84461 400 34872031
Overdose 100.72 14.22 47 84453 91012 34781419
Myalgia 100.08 14.22 39 84461 84071 34788360
Pain in extremity 100.01 14.22 95 84405 126418 34746013
Peripheral swelling 98.78 14.22 31 84469 76510 34795921
Tremor 98.75 14.22 38 84462 82549 34789882
Neurotoxicity 98.47 14.22 165 84335 17845 34854586
Herpes simplex 96.54 14.22 91 84409 5468 34866963
Intentional product misuse 96.51 14.22 3 84497 45608 34826823
Epstein-Barr virus infection 96.13 14.22 105 84395 7523 34864908
Drug resistance 94.86 14.22 200 84300 25727 34846704
Venoocclusive liver disease 94.10 14.22 106 84394 7860 34864571
Central nervous system lymphoma 93.67 14.22 47 84453 981 34871450
Drug hypersensitivity 89.94 14.22 41 84459 80488 34791943
White blood cell count decreased 89.84 14.22 462 84038 94983 34777448
Lymphopenia 88.43 14.22 149 84351 16186 34856245
Inappropriate schedule of product administration 88.32 14.22 21 84479 62275 34810156
Hospitalisation 87.21 14.22 16 84484 56886 34815545
Blood glucose increased 86.13 14.22 27 84473 66691 34805740
Malaise 86.12 14.22 202 84298 185623 34686808
Azoospermia 84.80 14.22 34 84466 407 34872024
Aspergillus infection 84.65 14.22 125 84375 12129 34860302
Hepatic failure 83.70 14.22 227 84273 34304 34838127
Haemophagocytic lymphohistiocytosis 83.45 14.22 128 84372 12845 34859586
Cerebrovascular accident 83.20 14.22 51 84449 84760 34787671
Confusional state 80.15 14.22 141 84359 144019 34728412
Stomatitis 78.74 14.22 254 84246 42260 34830171
Bradycardia 77.31 14.22 43 84457 75375 34797056
Musculoskeletal stiffness 76.29 14.22 11 84489 46669 34825762
Rheumatoid arthritis 75.92 14.22 4 84496 38234 34834197
Chest pain 75.07 14.22 119 84381 126643 34745788
Drug ineffective 75.00 14.22 1532 82968 455219 34417212
Suicide attempt 74.90 14.22 5 84495 39111 34833320
Anaplastic lymphoma kinase gene mutation 72.47 14.22 22 84478 104 34872327
Aggression 71.71 14.22 6 84494 38958 34833473
Viral haemorrhagic cystitis 71.14 14.22 41 84459 1139 34871292
Osteonecrosis 70.44 14.22 128 84372 14762 34857669
End stage renal disease 69.46 14.22 96 84404 8765 34863666
Left ventricular dysfunction 67.57 14.22 101 84399 9906 34862525
Nasopharyngitis 67.34 14.22 43 84457 69925 34802506
BK virus infection 67.17 14.22 76 84424 5662 34866769
Blood creatine phosphokinase increased 65.83 14.22 14 84486 44843 34827588
Post transplant lymphoproliferative disorder 65.67 14.22 80 84420 6448 34865983
Coronary artery disease 65.17 14.22 18 84482 48287 34824144
Myelopathy 63.89 14.22 51 84449 2446 34869985
Product use issue 63.67 14.22 312 84188 62904 34809527
Neutropenic colitis 63.46 14.22 56 84444 3088 34869343
Peripheral sensory neuropathy 63.43 14.22 80 84420 6680 34865751
Oedema peripheral 63.18 14.22 121 84379 119691 34752740
Strongyloidiasis 62.27 14.22 52 84448 2659 34869772
Plasma cell myeloma refractory 61.63 14.22 30 84470 585 34871846
Abdominal discomfort 61.48 14.22 34 84466 59801 34812630
Hallucination 61.04 14.22 24 84476 51474 34820957
Stress 60.80 14.22 3 84497 30344 34842087
Incorrect dose administered 60.79 14.22 12 84488 40503 34831928
Wheezing 60.59 14.22 13 84487 41389 34831042
B-cell lymphoma refractory 60.51 14.22 21 84479 162 34872269
Therapy non-responder 60.33 14.22 220 84280 38926 34833505
Agranulocytosis 60.14 14.22 159 84341 23662 34848769
Pneumonitis 59.67 14.22 199 84301 33679 34838752
Lymphoma transformation 59.01 14.22 23 84477 254 34872177
Loss of personal independence in daily activities 58.68 14.22 6 84494 33173 34839258
Contusion 58.43 14.22 9 84491 36355 34836076
Escherichia sepsis 57.97 14.22 64 84436 4640 34867791
Venoocclusive disease 57.73 14.22 51 84449 2816 34869615
Intestinal perforation 57.72 14.22 89 84411 8971 34863460
Gait disturbance 56.22 14.22 74 84426 85066 34787365
Traumatic lung injury 55.96 14.22 36 84464 1224 34871207
Refractory cancer 55.74 14.22 19 84481 138 34872293
Asthma 55.51 14.22 17 84483 42639 34829792
Heart rate decreased 55.47 14.22 6 84494 31739 34840692
Sleep disorder 55.35 14.22 6 84494 31682 34840749
Fungal infection 54.92 14.22 120 84380 15815 34856616
Hypoglycaemia 54.77 14.22 32 84468 54608 34817823
Chronic obstructive pulmonary disease 54.45 14.22 25 84475 48893 34823538
Injection site pain 53.62 14.22 14 84486 38991 34833440
Memory impairment 53.33 14.22 19 84481 43299 34829132
Psoriasis 53.22 14.22 14 84486 38798 34833633
Agitation 52.91 14.22 37 84463 57362 34815069
Hyperhidrosis 52.88 14.22 63 84437 75629 34796802
Infection reactivation 52.62 14.22 37 84463 1461 34870970
Aplasia 52.40 14.22 60 84440 4528 34867903
Bronchopulmonary aspergillosis 52.36 14.22 112 84388 14547 34857884
Cytomegalovirus infection reactivation 51.93 14.22 63 84437 5055 34867376
Nephropathy toxic 51.84 14.22 102 84398 12486 34859945
Loss of consciousness 50.45 14.22 76 84424 82591 34789840
Administration site extravasation 50.29 14.22 26 84474 579 34871852
Pneumonia fungal 49.87 14.22 73 84427 7027 34865404
Malignant transformation 49.80 14.22 29 84471 822 34871609
Cardio-respiratory arrest 49.16 14.22 37 84463 55236 34817195
Salivary gland cancer 49.10 14.22 21 84479 299 34872132
Escherichia infection 48.38 14.22 78 84422 8167 34864264
JC virus infection 47.94 14.22 41 84459 2167 34870264
Urticaria 47.90 14.22 48 84452 62329 34810102
Chloroma 47.78 14.22 24 84476 502 34871929
Post embolisation syndrome 47.41 14.22 14 84486 59 34872372
Arthropathy 47.24 14.22 5 84495 26902 34845529
Peripheral T-cell lymphoma unspecified 47.14 14.22 23 84477 451 34871980
Respiratory failure 46.92 14.22 434 84066 108138 34764293
Infection 46.92 14.22 378 84122 90537 34781894
Acute lymphocytic leukaemia 45.87 14.22 46 84454 2983 34869448
Gastritis bacterial 45.69 14.22 18 84482 205 34872226
Ill-defined disorder 44.85 14.22 102 84398 13807 34858624
Device related thrombosis 44.03 14.22 30 84470 1125 34871306
Product prescribing error 43.69 14.22 3 84497 22924 34849507
Lung infiltration 43.13 14.22 96 84404 12809 34859622
Gene mutation 43.12 14.22 32 84468 1376 34871055
Anal inflammation 43.11 14.22 31 84469 1269 34871162
Platelet count decreased 42.75 14.22 460 84040 119257 34753174
Retinal haemorrhage 42.71 14.22 57 84443 5032 34867399
Heart rate increased 42.54 14.22 30 84470 46313 34826118
Epstein-Barr virus associated lymphoma 42.39 14.22 24 84476 644 34871787
Multiple organ dysfunction syndrome 42.06 14.22 323 84177 76243 34796188
Autoimmune neutropenia 41.67 14.22 18 84482 263 34872168
Cardiac failure 41.07 14.22 368 84132 90880 34781551
Neoplasm 41.01 14.22 58 84442 5409 34867022
Pneumonia klebsiella 40.84 14.22 45 84455 3255 34869176
Cytogenetic abnormality 40.81 14.22 26 84474 869 34871562
Gastrointestinal toxicity 40.64 14.22 41 84459 2678 34869753
Congenital cardiovascular anomaly 40.48 14.22 16 84484 184 34872247
Unevaluable event 38.92 14.22 15 84485 32575 34839856
Injury 38.58 14.22 3 84497 20684 34851747
Spinal column injury 38.47 14.22 22 84478 602 34871829
Endocarditis noninfective 38.46 14.22 14 84486 126 34872305
Blood cholesterol increased 38.25 14.22 3 84497 20540 34851891
Vision blurred 38.08 14.22 33 84467 45930 34826501
Hypertension 37.98 14.22 185 84315 136258 34736173
Nephrolithiasis 37.86 14.22 13 84487 30320 34842111
Abdominal pain upper 37.83 14.22 72 84428 71418 34801013
Blood stem cell transplant failure 37.59 14.22 19 84481 403 34872028
Mobility decreased 37.45 14.22 13 84487 30115 34842316
Angioedema 37.29 14.22 22 84478 37352 34835079
Gastrooesophageal reflux disease 36.90 14.22 23 84477 37901 34834530
Dry skin 36.38 14.22 15 84485 31272 34841159
Back pain 36.34 14.22 161 84339 121628 34750803
Staphylococcal sepsis 36.07 14.22 76 84424 9768 34862663
Pseudomonas infection 35.78 14.22 87 84413 12295 34860136
Cardiac failure congestive 35.78 14.22 94 84406 83176 34789255
Metastases to spleen 35.70 14.22 19 84481 450 34871981
International normalised ratio increased 35.67 14.22 37 84463 47290 34825141
Acute lymphocytic leukaemia recurrent 35.09 14.22 40 84460 3004 34869427
Interstitial lung disease 35.07 14.22 274 84226 65008 34807423
Pneumonia 34.96 14.22 1134 83366 361493 34510938
Weight decreased 34.94 14.22 266 84234 176035 34696396
Diarrhoea 34.94 14.22 699 83801 389213 34483218
Bacteraemia 34.87 14.22 116 84384 19601 34852830
Recurrent cancer 34.78 14.22 28 84472 1359 34871072
Osteosarcoma recurrent 34.77 14.22 9 84491 20 34872411
Cardiac arrest 34.52 14.22 118 84382 96041 34776390
Syncope 34.36 14.22 110 84390 91341 34781090
Colitis 34.26 14.22 181 84319 37569 34834862
Metastases to lung 34.20 14.22 72 84428 9248 34863183
Transformation to acute myeloid leukaemia 34.09 14.22 22 84478 752 34871679
Drug withdrawal syndrome 34.02 14.22 4 84496 19830 34852601
Blood pressure systolic increased 34.00 14.22 7 84493 22945 34849486
Chylothorax 33.91 14.22 22 84478 759 34871672
Drug ineffective for unapproved indication 33.80 14.22 130 84370 23585 34848846
Pneumothorax spontaneous 33.47 14.22 20 84480 595 34871836
Cerebral toxoplasmosis 33.43 14.22 30 84470 1691 34870740
Chest discomfort 33.39 14.22 50 84450 54480 34817951
Ganglioneuroblastoma 32.84 14.22 9 84491 27 34872404
Balance disorder 32.70 14.22 30 84470 40624 34831807
Cardiac dysfunction 32.67 14.22 34 84466 2304 34870127
Abdominal neoplasm 32.67 14.22 17 84483 384 34872047
Autoimmune lymphoproliferative syndrome 32.62 14.22 13 84487 153 34872278
Haemorrhage 32.53 14.22 46 84454 51324 34821107
Accidental overdose 32.32 14.22 5 84495 20135 34852296
Chronic myeloid leukaemia 32.26 14.22 33 84467 2191 34870240
Blood pressure decreased 31.77 14.22 47 84453 51468 34820963
Osteosarcoma 31.50 14.22 15 84485 278 34872153
Toxicity to various agents 31.45 14.22 321 84179 200041 34672390
Road traffic accident 31.26 14.22 3 84497 17447 34854984
Blood HIV RNA increased 31.21 14.22 25 84475 1205 34871226
Disorientation 31.10 14.22 21 84479 33167 34839264
Congestive cardiomyopathy 31.10 14.22 61 84439 7449 34864982
Glioma 31.08 14.22 16 84484 353 34872078
COVID-19 pneumonia 31.06 14.22 101 84399 16866 34855565
Drug reaction with eosinophilia and systemic symptoms 30.78 14.22 21 84479 32991 34839440
5q minus syndrome 30.59 14.22 12 84488 135 34872296
Hepatic fibrosis 30.39 14.22 46 84454 4561 34867870
Pleural effusion 30.34 14.22 316 84184 81230 34791201
Swelling 29.86 14.22 35 84465 42331 34830100
Splenic lesion 29.72 14.22 14 84486 253 34872178
Oxygen saturation decreased 29.54 14.22 53 84447 53765 34818666
Bone marrow infiltration 29.43 14.22 13 84487 201 34872230
Transient ischaemic attack 29.37 14.22 15 84485 27598 34844833
Abnormal behaviour 28.99 14.22 12 84488 24957 34847474
Subdural hygroma 28.98 14.22 15 84485 335 34872096
Respiratory arrest 28.70 14.22 16 84484 28027 34844404
SARS-CoV-2 test negative 28.62 14.22 22 84478 998 34871433
Hyperkalaemia 28.55 14.22 80 84420 69309 34803122
Erythema 28.55 14.22 114 84386 88666 34783765
Irritability 28.45 14.22 12 84488 24678 34847753
Adverse drug reaction 28.26 14.22 18 84482 29324 34843107
Gastrointestinal haemorrhage 28.21 14.22 114 84386 88363 34784068
Peripheral motor neuropathy 28.15 14.22 28 84472 1798 34870633
Head injury 28.04 14.22 5 84495 18155 34854276
Psychotic disorder 27.99 14.22 12 84488 24440 34847991
Product quality issue 27.86 14.22 4 84496 17031 34855400
Gastrosplenic fistula 27.73 14.22 9 84491 55 34872376
Hepatosplenic candidiasis 27.70 14.22 13 84487 233 34872198
Renal-limited thrombotic microangiopathy 27.67 14.22 10 84490 88 34872343
Toxic erythema of chemotherapy 27.57 14.22 10 84490 89 34872342
Treatment failure 27.32 14.22 200 84300 46497 34825934
Cardiomyopathy acute 27.23 14.22 8 84492 33 34872398
Haematochezia 27.21 14.22 44 84456 46490 34825941
Immunosuppression 27.07 14.22 52 84448 6252 34866179
Pneumocystis jirovecii infection 27.02 14.22 27 84473 1743 34870688
Nausea 27.02 14.22 621 83879 339287 34533144
Stevens-Johnson syndrome 26.97 14.22 6 84494 18633 34853798
Klebsiella infection 26.88 14.22 62 84438 8469 34863962
Tidal volume decreased 26.85 14.22 8 84492 35 34872396
Primitive neuroectodermal tumour 26.81 14.22 9 84491 62 34872369
Pulmonary toxicity 26.76 14.22 51 84449 6096 34866335
Toxic cardiomyopathy 26.68 14.22 13 84487 254 34872177
Mass 26.64 14.22 59 84441 7846 34864585
Meningitis tuberculous 26.61 14.22 18 84482 667 34871764
Fluid retention 26.58 14.22 16 84484 26871 34845560
Herpes simplex encephalitis 26.52 14.22 14 84486 326 34872105
Burning sensation 26.45 14.22 6 84494 18388 34854043
Unresponsive to stimuli 26.43 14.22 17 84483 27552 34844879
Depressed mood 26.42 14.22 7 84493 19310 34853121
Drug clearance decreased 26.42 14.22 27 84473 1791 34870640
Encephalitis enteroviral 26.42 14.22 11 84489 146 34872285
Secondary immunodeficiency 26.41 14.22 15 84485 405 34872026
Escherichia bacteraemia 26.40 14.22 36 84464 3244 34869187
COVID-19 26.29 14.22 295 84205 77255 34795176
Hypertriglyceridaemia 26.18 14.22 61 84439 8387 34864044
Treatment noncompliance 26.04 14.22 18 84482 28082 34844349
Plasmacytoma 25.99 14.22 38 84462 3653 34868778
Renal tubular disorder 25.99 14.22 43 84457 4600 34867831
Haemoglobin abnormal 25.96 14.22 39 84461 3841 34868590
Hypoaesthesia 25.90 14.22 70 84430 61374 34811057
Visual impairment 25.86 14.22 29 84471 35773 34836658
Device related infection 25.81 14.22 96 84404 17141 34855290
Lip swelling 25.78 14.22 4 84496 16076 34856355
Pseudomonal bacteraemia 25.69 14.22 24 84476 1425 34871006
Labelled drug-drug interaction medication error 25.65 14.22 3 84497 14936 34857495
Injection site erythema 25.39 14.22 4 84496 15895 34856536
Acute lymphocytic leukaemia refractory 25.30 14.22 10 84490 115 34872316
West Nile viral infection 25.20 14.22 18 84482 729 34871702
Biliary-bronchial fistula 25.14 14.22 5 84495 0 34872431
Cytomegalovirus hepatitis 25.05 14.22 15 84485 448 34871983
Adenocarcinoma gastric 24.96 14.22 22 84478 1211 34871220
Sleep apnoea syndrome 24.86 14.22 9 84491 20312 34852119
Skin exfoliation 24.85 14.22 18 84482 27414 34845017
Flushing 24.82 14.22 25 84475 32395 34840036
Intestinal atresia 24.72 14.22 9 84491 81 34872350
Amnesia 24.63 14.22 17 84483 26546 34845885
Electrocardiogram QT prolonged 24.63 14.22 38 84462 40914 34831517
Eczema 24.62 14.22 7 84493 18429 34854002
Plasma cell myeloma recurrent 24.52 14.22 41 84459 4424 34868007
Dysgeusia 24.51 14.22 17 84483 26480 34845951
Nightmare 24.44 14.22 3 84497 14388 34858043
Cellulitis gangrenous 24.23 14.22 11 84489 182 34872249
Metastases to retroperitoneum 24.20 14.22 12 84488 244 34872187
Hepatitis 24.06 14.22 118 84382 23786 34848645
Mucosal toxicity 23.98 14.22 12 84488 249 34872182
Gastric perforation 23.92 14.22 30 84470 2490 34869941
Hypersensitivity 23.92 14.22 72 84428 60963 34811468
Swelling face 23.91 14.22 13 84487 23092 34849339
Hepatic infection fungal 23.91 14.22 11 84489 188 34872243
Peripheral sensorimotor neuropathy 23.91 14.22 24 84476 1558 34870873
Viral load increased 23.86 14.22 30 84470 2497 34869934
Refractory anaemia with an excess of blasts 23.84 14.22 14 84486 403 34872028
Bone marrow disorder 23.83 14.22 25 84475 1710 34870721
Extravasation 23.78 14.22 26 84474 1864 34870567
Metastases to meninges 23.72 14.22 23 84477 1431 34871000
Disturbance in attention 23.54 14.22 17 84483 25928 34846503
Ototoxicity 23.48 14.22 26 84474 1891 34870540
Dry mouth 23.39 14.22 23 84477 30142 34842289
Disorder of orbit 23.37 14.22 9 84491 96 34872335
Laboratory test abnormal 23.35 14.22 10 84490 20381 34852050
Neurofibrosarcoma 23.25 14.22 7 84493 32 34872399
Ureteric compression 23.18 14.22 12 84488 268 34872163
Proctalgia 23.11 14.22 46 84454 5677 34866754
Hepatotoxicity 23.03 14.22 108 84392 21377 34851054
Wrong technique in product usage process 23.01 14.22 32 84468 35954 34836477
Staphylococcal bacteraemia 22.96 14.22 58 84442 8394 34864037
Marginal zone lymphoma recurrent 22.90 14.22 7 84493 34 34872397
Vertigo 22.82 14.22 17 84483 25519 34846912
Plasmablastic lymphoma 22.79 14.22 13 84487 354 34872077
Molluscum contagiosum 22.71 14.22 12 84488 280 34872151
Metastasis 22.69 14.22 38 84462 4106 34868325
Pathogen resistance 22.63 14.22 62 84438 9420 34863011
Dehydration 22.59 14.22 203 84297 129766 34742665
Small intestinal perforation 22.48 14.22 27 84473 2144 34870287
Skin toxicity 22.46 14.22 41 84459 4743 34867688
Acute hepatic failure 22.44 14.22 80 84420 13994 34858437
Candida pneumonia 22.44 14.22 14 84486 451 34871980
Myelitis transverse 22.40 14.22 20 84480 1120 34871311
Chromosome analysis abnormal 22.39 14.22 10 84490 159 34872272
Clostridium difficile colitis 22.23 14.22 86 84414 15644 34856787
Psoriatic arthropathy 22.21 14.22 10 84490 19788 34852643
Haematopoietic stem cell mobilisation 22.16 14.22 10 84490 163 34872268
Influenza 22.15 14.22 55 84445 49611 34822820
Candida endophthalmitis 22.13 14.22 9 84491 112 34872319
Cutaneous T-cell lymphoma recurrent 22.11 14.22 7 84493 39 34872392
Hot flush 22.10 14.22 8 84492 18058 34854373
Respiratory depression 22.00 14.22 6 84494 16239 34856192
Enterococcal bacteraemia 21.99 14.22 25 84475 1872 34870559
Meningitis cryptococcal 21.84 14.22 28 84472 2376 34870055
Lymphocytosis 21.84 14.22 29 84471 2548 34869883
Metastases to muscle 21.73 14.22 11 84489 234 34872197
Surgery 21.64 14.22 4 84496 14153 34858278
Immune effector cell-associated neurotoxicity syndrome 21.61 14.22 35 84465 3678 34868753
Pulmonary sarcoidosis 21.59 14.22 15 84485 581 34871850
Hallucination, visual 21.56 14.22 8 84492 17783 34854648
Phlebitis infective 21.51 14.22 9 84491 121 34872310
Blood urea increased 21.49 14.22 25 84475 30339 34842092
B-cell type acute leukaemia 21.47 14.22 12 84488 314 34872117
Restlessness 21.46 14.22 18 84482 25464 34846967
Plasma cell leukaemia 21.46 14.22 18 84482 926 34871505
Injection site reaction 21.45 14.22 3 84497 13030 34859401
Streptococcal infection 21.40 14.22 41 84459 4920 34867511
Tracheal fistula 21.38 14.22 9 84491 123 34872308
Sphingomonas paucimobilis infection 21.26 14.22 7 84493 45 34872386
Spindle cell sarcoma 21.18 14.22 9 84491 126 34872305
Acute hepatitis B 21.17 14.22 10 84490 182 34872249
Lactic acidosis 21.17 14.22 32 84468 34740 34837691
Herpes zoster 21.09 14.22 149 84351 34250 34838181
Gait inability 21.02 14.22 12 84488 20746 34851685
Corynebacterium infection 20.94 14.22 15 84485 610 34871821
Glioblastoma multiforme 20.89 14.22 16 84484 722 34871709
Musculoskeletal pain 20.86 14.22 28 84472 31935 34840496
Infusion site discolouration 20.80 14.22 9 84491 132 34872299
Helicobacter sepsis 20.77 14.22 6 84494 23 34872408
Mucormycosis 20.76 14.22 45 84455 5897 34866534
Spinal cord ischaemia 20.72 14.22 8 84492 86 34872345
Bacterial infection 20.71 14.22 89 84411 16974 34855457
Discomfort 20.57 14.22 10 84490 18928 34853503
Metastases to bone marrow 20.57 14.22 14 84486 524 34871907
Morphoea 20.50 14.22 10 84490 196 34872235
Taeniasis 20.40 14.22 7 84493 52 34872379
Influenza like illness 20.38 14.22 22 84478 27612 34844819
Depressed level of consciousness 20.25 14.22 46 84454 42795 34829636
Positron emission tomogram abnormal 20.04 14.22 9 84491 145 34872286
Neck pain 20.04 14.22 19 84481 25330 34847101
Splenic marginal zone lymphoma 20.00 14.22 6 84494 27 34872404
Arthritis 19.91 14.22 28 84472 31318 34841113
Periorbital infection 19.88 14.22 9 84491 148 34872283
Mucoepidermoid carcinoma of salivary gland 19.67 14.22 5 84495 10 34872421
Leukoencephalopathy 19.63 14.22 36 84464 4179 34868252
Disseminated cytomegaloviral infection 19.62 14.22 10 84490 216 34872215
Testicular disorder 19.55 14.22 16 84484 795 34871636
Suspected product quality issue 19.55 14.22 9 84491 154 34872277
Granulocyte count decreased 19.48 14.22 16 84484 799 34871632
Rhabdomyosarcoma recurrent 19.43 14.22 8 84492 103 34872328
Thrombosis 19.43 14.22 60 84440 50398 34822033
Cryptosporidiosis infection 19.43 14.22 13 84487 473 34871958
Acute lung injury 19.40 14.22 21 84479 1489 34870942
Blindness cortical 19.39 14.22 12 84488 381 34872050
Peritoneal lesion 19.36 14.22 8 84492 104 34872327
Hepatitis viral 19.34 14.22 14 84486 579 34871852
Sarcoma metastatic 19.33 14.22 7 84493 62 34872369
Coma 19.28 14.22 52 84448 45626 34826805
Hepatic amoebiasis 19.23 14.22 7 84493 63 34872368
Palmar-plantar erythrodysaesthesia syndrome 19.16 14.22 86 84414 16709 34855722
Gastrointestinal protozoal infection 19.13 14.22 7 84493 64 34872367
Hip fracture 19.04 14.22 3 84497 11922 34860509
Acute pulmonary histoplasmosis 19.04 14.22 9 84491 164 34872267
Salivary gland neoplasm 19.01 14.22 6 84494 33 34872398
Lentigo 19.00 14.22 13 84487 491 34871940
Adverse event 18.99 14.22 11 84489 18866 34853565
Human herpesvirus 8 infection 18.95 14.22 17 84483 958 34871473
Extrapyramidal disorder 18.93 14.22 4 84496 12876 34859555
Dementia 18.77 14.22 5 84495 13743 34858688
Disease susceptibility 18.76 14.22 7 84493 68 34872363
B-cell lymphoma 18.75 14.22 36 84464 4327 34868104
Obstructive airways disorder 18.72 14.22 7 84493 15487 34856944
Swollen tongue 18.68 14.22 6 84494 14599 34857832
Dyskinesia 18.67 14.22 16 84484 22397 34850034
Leukaemia 18.59 14.22 37 84463 4566 34867865
Oesophageal candidiasis 18.56 14.22 36 84464 4360 34868071
Liver function test abnormal 18.53 14.22 29 84471 31045 34841386
Delusion 18.42 14.22 4 84496 12631 34859800
Blastic plasmacytoid dendritic cell neoplasia 18.40 14.22 7 84493 72 34872359
Rectal haemorrhage 18.39 14.22 44 84456 40205 34832226
Scedosporium infection 18.38 14.22 16 84484 866 34871565
Splenic candidiasis 18.32 14.22 7 84493 73 34872358
Neutrophil count increased 18.23 14.22 86 84414 17060 34855371
Diabetes mellitus inadequate control 18.18 14.22 5 84495 13459 34858972
Gastric stenosis 18.15 14.22 7 84493 75 34872356
Medication error 18.14 14.22 21 84479 25544 34846887
Facial paresis 18.10 14.22 29 84471 3020 34869411
Hypersomnia 17.94 14.22 4 84496 12403 34860028
Mental status changes 17.91 14.22 41 84459 38042 34834389
Chromosomal mutation 17.88 14.22 4 84496 3 34872428
Haemoptysis 17.87 14.22 36 84464 34970 34837461
Guillain-Barre syndrome 17.83 14.22 43 84457 6044 34866387
Cancer fatigue 17.83 14.22 7 84493 79 34872352
Premature ageing 17.75 14.22 7 84493 80 34872351
Hepatitis B DNA increased 17.66 14.22 13 84487 552 34871879
Urethral obstruction 17.63 14.22 9 84491 195 34872236
Ventricular tachycardia 17.63 14.22 23 84477 26556 34845875
Colitis ulcerative 17.53 14.22 9 84491 16511 34855920
Wound 17.49 14.22 7 84493 14857 34857574
Diabetic ketoacidosis 17.45 14.22 11 84489 18021 34854410
Hepatosplenomegaly 17.43 14.22 34 84466 4135 34868296
Clostridium difficile infection 17.41 14.22 91 84409 18807 34853624
Febrile infection 17.39 14.22 24 84476 2187 34870244
Anaplastic large-cell lymphoma 17.37 14.22 7 84493 85 34872346
Pneumonia adenoviral 17.31 14.22 11 84489 366 34872065
Chronic lymphocytic leukaemia refractory 17.29 14.22 7 84493 86 34872345
Asthenia 17.28 14.22 456 84044 244795 34627636
Rhinorrhoea 17.25 14.22 22 84478 25646 34846785
Rash pruritic 17.18 14.22 24 84476 26917 34845514
Fanconi syndrome 17.17 14.22 21 84479 1699 34870732
Urinary retention 17.12 14.22 39 84461 36249 34836182
Systemic mycosis 17.01 14.22 20 84480 1553 34870878
Pneumonia salmonella 16.99 14.22 6 84494 49 34872382
Coronary artery occlusion 16.97 14.22 3 84497 10959 34861472
Renal disorder 16.95 14.22 22 84478 25458 34846973
Cough 16.95 14.22 258 84242 149882 34722549
Dyspepsia 16.91 14.22 40 84460 36692 34835739
Enterovirus infection 16.85 14.22 16 84484 970 34871461
Resorption bone increased 16.84 14.22 9 84491 215 34872216
Cerebral aspergillosis 16.82 14.22 19 84481 1413 34871018
Retroperitoneal mass 16.80 14.22 7 84493 93 34872338
Cardiac disorder 16.80 14.22 51 84449 43075 34829356
Graft versus host disease 16.78 14.22 60 84440 10509 34861922
Granulocytopenia neonatal 16.76 14.22 5 84495 22 34872409
Enterococcal infection 16.67 14.22 55 84445 9251 34863180
Embolism 16.55 14.22 49 84451 7780 34864651
Cholelithiasis 16.54 14.22 16 84484 21132 34851299
Human polyomavirus infection 16.53 14.22 14 84486 730 34871701
Focal nodular hyperplasia 16.48 14.22 8 84492 155 34872276
Cryptococcal fungaemia 16.47 14.22 7 84493 98 34872333
Limb injury 16.44 14.22 4 84496 11685 34860746
Superior vena cava syndrome 16.38 14.22 13 84487 618 34871813
Nasal congestion 16.30 14.22 19 84481 23038 34849393
Ileus 16.28 14.22 81 84419 16418 34856013
Speech disorder 16.26 14.22 23 84477 25663 34846768
Skin laceration 16.24 14.22 5 84495 12504 34859927
Myeloid leukaemia 16.16 14.22 11 84489 412 34872019
Blood triglycerides increased 16.12 14.22 7 84493 14152 34858279
Condition aggravated 16.12 14.22 348 84152 191848 34680583
Ichthyosis 16.10 14.22 7 84493 104 34872327
Eosinophilia 16.09 14.22 24 84476 26198 34846233
IIIrd nerve paresis 16.04 14.22 7 84493 105 34872326
Appendiceal abscess 15.98 14.22 7 84493 106 34872325
Abdominal wound dehiscence 15.98 14.22 7 84493 106 34872325
Wound evisceration 15.92 14.22 7 84493 107 34872324
Adenoviral hepatitis 15.85 14.22 12 84488 532 34871899
Diabetes mellitus 15.82 14.22 59 84441 46814 34825617
Pneumonia respiratory syncytial viral 15.82 14.22 15 84485 908 34871523
Neuroendocrine carcinoma of the skin 15.79 14.22 14 84486 777 34871654
Postural tremor 15.78 14.22 10 84490 331 34872100
Mastitis 15.77 14.22 8 84492 171 34872260
Carnitine deficiency 15.69 14.22 7 84493 111 34872320
Bladder cancer 15.66 14.22 10 84490 16268 34856163
Congenital hepatobiliary anomaly 15.62 14.22 5 84495 29 34872402
Adrenocortical carcinoma 15.62 14.22 5 84495 29 34872402
Therapy responder 15.60 14.22 8 84492 175 34872256
Asthenospermia 15.58 14.22 6 84494 64 34872367
Transplant rejection 15.58 14.22 3 84497 10308 34862123
Venous thrombosis 15.58 14.22 29 84471 3406 34869025
Catheter site thrombosis 15.58 14.22 7 84493 113 34872318
Body temperature decreased 15.56 14.22 6 84494 13028 34859403
Nervous system disorder 15.51 14.22 73 84427 14470 34857961
Sopor 15.49 14.22 5 84495 12131 34860300
Visual acuity reduced 15.42 14.22 10 84490 16139 34856292
Leukonychia 15.42 14.22 4 84496 9 34872422
Ear infection 15.41 14.22 3 84497 10228 34862203
Scleroderma 15.38 14.22 19 84481 1553 34870878
Hepatic enzyme increased 15.38 14.22 46 84454 39034 34833397
Combined immunodeficiency 15.34 14.22 6 84494 67 34872364
Cerebral haemorrhage 15.33 14.22 39 84461 34898 34837533
Aplastic anaemia 15.29 14.22 55 84445 9661 34862770
Abdominal distension 15.29 14.22 81 84419 58411 34814020
Benign prostatic hyperplasia 15.23 14.22 8 84492 14487 34857944
Seizure 15.21 14.22 171 84329 104686 34767745
Haematoma 15.17 14.22 24 84476 25581 34846850
Acne 15.15 14.22 4 84496 11062 34861369
Delirium 15.09 14.22 55 84445 43936 34828495
Sudden death 15.09 14.22 9 84491 15192 34857239
Administration site injury 15.08 14.22 3 84497 0 34872431
Cataract 15.08 14.22 25 84475 26161 34846270
Therapeutic product effect decreased 15.08 14.22 39 84461 34704 34837727
Lewis-Sumner syndrome 14.95 14.22 5 84495 34 34872397
Neuroborreliosis 14.95 14.22 5 84495 34 34872397
Paternal exposure timing unspecified 14.95 14.22 5 84495 34 34872397
Acute myelomonocytic leukaemia 14.89 14.22 7 84493 126 34872305
Abdominal lymphadenopathy 14.87 14.22 14 84486 840 34871591
Epidural haemorrhage 14.80 14.22 6 84494 74 34872357
Diffuse alopecia 14.80 14.22 6 84494 74 34872357
Joint stiffness 14.76 14.22 4 84496 10869 34861562
Metabolic acidosis 14.73 14.22 55 84445 43625 34828806
Pneumaturia 14.70 14.22 5 84495 36 34872395
Genotoxicity 14.70 14.22 5 84495 36 34872395
Orthostatic hypotension 14.69 14.22 25 84475 25894 34846537
Blood urine present 14.68 14.22 4 84496 10830 34861601
Metastases to chest wall 14.68 14.22 8 84492 199 34872232
Fusarium infection 14.67 14.22 16 84484 1144 34871287
Rales 14.67 14.22 3 84497 9880 34862551
Prostate cancer 14.66 14.22 48 84452 39601 34832830
Metapneumovirus bronchiolitis 14.59 14.22 4 84496 12 34872419
Peripheral T-cell lymphoma unspecified refractory 14.59 14.22 4 84496 12 34872419
Food protein-induced enterocolitis syndrome 14.59 14.22 5 84495 37 34872394
Hepatitis C RNA increased 14.53 14.22 9 84491 286 34872145
Bronchiectasis 14.50 14.22 3 84497 9798 34862633
B precursor type acute leukaemia 14.39 14.22 8 84492 207 34872224
Klebsiella sepsis 14.38 14.22 21 84479 2016 34870415
Palpitations 14.38 14.22 49 84451 39937 34832494
Hyposplenism 14.35 14.22 4 84496 13 34872418
Chemotherapeutic drug level increased 14.29 14.22 8 84492 210 34872221

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 8548.78 12.33 5536 160497 225463 79352892
Neutropenia 3428.35 12.33 3570 162463 284140 79294215
Disease progression 2303.56 12.33 2350 163683 182012 79396343
Acute myeloid leukaemia 1522.82 12.33 893 165140 29992 79548363
Mucosal inflammation 1445.57 12.33 1223 164810 74357 79503998
Myelodysplastic syndrome 1337.66 12.33 816 165217 29485 79548870
Second primary malignancy 1315.49 12.33 628 165405 13722 79564633
Haematotoxicity 1301.50 12.33 639 165394 14880 79563475
Off label use 1216.88 12.33 4386 161647 902829 78675526
Product use in unapproved indication 1199.63 12.33 1987 164046 248372 79329983
Cardiotoxicity 1162.80 12.33 549 165484 11690 79566665
Thrombocytopenia 1086.00 12.33 1964 164069 263295 79315060
Pancytopenia 1072.49 12.33 1513 164520 164232 79414123
Diffuse large B-cell lymphoma recurrent 1012.98 12.33 367 165666 3840 79574515
Bone marrow failure 984.99 12.33 831 165202 50276 79528079
Myelosuppression 861.58 12.33 696 165337 39600 79538755
Hepatitis B reactivation 853.27 12.33 359 165674 5749 79572606
Malignant neoplasm progression 840.48 12.33 1215 164818 134775 79443580
Tumour lysis syndrome 728.84 12.33 511 165522 23428 79554927
Hepatitis B 716.24 12.33 349 165684 7983 79570372
Cardiomyopathy 688.18 12.33 531 165502 28243 79550112
Pneumocystis jirovecii pneumonia 681.19 12.33 555 165478 31953 79546402
Febrile bone marrow aplasia 669.37 12.33 387 165646 12633 79565722
Neoplasm progression 622.12 12.33 647 165386 51035 79527320
Therapy partial responder 563.94 12.33 386 165647 17011 79561344
Interstitial lung disease 523.68 12.33 883 165150 111717 79466638
Neutropenic sepsis 502.66 12.33 431 165602 26633 79551722
Joint swelling 500.69 12.33 24 166009 288622 79289733
Neuropathy peripheral 498.46 12.33 983 165050 140322 79438033
Ejection fraction decreased 497.48 12.33 477 165556 34100 79544255
Fall 489.12 12.33 202 165831 487427 79090928
Leukopenia 484.88 12.33 870 165163 115643 79462712
Septic shock 484.52 12.33 896 165137 121905 79456450
Cytopenia 473.98 12.33 370 165663 20013 79558342
Arthralgia 441.95 12.33 328 165705 571475 79006880
Sepsis 438.90 12.33 1395 164638 268033 79310322
Anaemia 433.76 12.33 1954 164079 443061 79135294
Neutrophil count decreased 418.57 12.33 723 165310 93236 79485119
Pyrexia 415.08 12.33 2620 163413 676089 78902266
Pain 414.57 12.33 515 165518 703287 78875068
Rheumatoid arthritis 402.91 12.33 6 166027 208464 79369891
Product dose omission issue 363.79 12.33 44 165989 247493 79330862
Posterior reversible encephalopathy syndrome 352.63 12.33 349 165684 25932 79552423
Disease recurrence 341.57 12.33 440 165593 43669 79534686
Peripheral swelling 338.13 12.33 74 165959 269543 79308812
Headache 333.37 12.33 530 165503 653242 78925113
Progressive multifocal leukoencephalopathy 316.94 12.33 295 165738 20305 79558050
Pruritus 308.93 12.33 223 165810 394425 79183930
Drug hypersensitivity 308.92 12.33 118 165915 298798 79279557
Cardiac failure 307.07 12.33 860 165173 153982 79424373
Diffuse large B-cell lymphoma refractory 300.54 12.33 113 165920 1322 79577033
Palmar-plantar erythrodysaesthesia syndrome 297.44 12.33 356 165677 32778 79545577
Left ventricular dysfunction 297.37 12.33 277 165756 19084 79559271
Dizziness 295.35 12.33 399 165634 526042 79052313
Abdominal discomfort 294.45 12.33 79 165954 250648 79327707
Synovitis 288.43 12.33 5 166028 150729 79427626
Weight increased 275.98 12.33 116 165917 277270 79301085
Nasopharyngitis 274.57 12.33 93 165940 253788 79324567
Drug abuse 274.21 12.33 16 166017 162675 79415680
Arthropathy 266.36 12.33 29 166004 177082 79401273
Acquired gene mutation 265.07 12.33 117 165916 2116 79576239
Musculoskeletal stiffness 262.32 12.33 29 166004 174979 79403376
Rash 260.95 12.33 506 165527 577852 79000503
Metastases to bone 248.62 12.33 280 165753 24147 79554208
Swelling 245.67 12.33 73 165960 216638 79361717
B-cell lymphoma recurrent 243.57 12.33 88 165945 912 79577443
Lymphadenopathy 239.98 12.33 412 165621 52835 79525520
Cytomegalovirus chorioretinitis 237.39 12.33 146 165887 5344 79573011
Anxiety 228.45 12.33 116 165917 248396 79329959
Blood pressure increased 222.36 12.33 81 165952 211279 79367076
Insomnia 218.64 12.33 119 165914 245051 79333304
Metastases to lung 215.96 12.33 226 165807 17937 79560418
Congestive cardiomyopathy 211.40 12.33 184 165849 11596 79566759
Polyneuropathy 209.42 12.33 255 165778 23896 79554459
Neutropenic colitis 205.01 12.33 135 165898 5572 79572783
Pain in extremity 204.50 12.33 276 165757 364262 79214093
Haemophagocytic lymphohistiocytosis 203.20 12.33 239 165794 21598 79556757
Neurotoxicity 202.64 12.33 292 165741 32226 79546129
Muscle spasms 201.43 12.33 57 165976 174673 79403682
Intentional overdose 200.72 12.33 4 166029 105956 79472399
Contusion 196.51 12.33 36 165997 148740 79429615
White blood cell count decreased 195.07 12.33 843 165190 187445 79390910
Blood lactate dehydrogenase increased 193.73 12.33 316 165717 38854 79539501
Overdose 193.07 12.33 71 165962 184135 79394220
Contraindicated product administered 191.88 12.33 46 165987 157492 79420863
Pemphigus 191.76 12.33 3 166030 99579 79478776
Hypogammaglobulinaemia 190.65 12.33 181 165852 12770 79565585
Acute promyelocytic leukaemia 186.32 12.33 81 165952 1410 79576945
Therapeutic product effect decreased 186.04 12.33 55 165978 163808 79414547
Feeling abnormal 185.24 12.33 51 165982 159148 79419207
Platelet count decreased 184.67 12.33 849 165184 193815 79384540
Cystitis haemorrhagic 182.45 12.33 152 165881 9020 79569335
Multiple organ dysfunction syndrome 182.21 12.33 608 165425 119638 79458717
Metastases to liver 181.94 12.33 258 165775 28056 79550299
Wound 179.91 12.33 17 166016 116162 79462193
Intentional product misuse 178.64 12.33 4 166029 95161 79483194
Aplasia 177.55 12.33 140 165893 7680 79570675
Somnolence 176.65 12.33 143 165890 238838 79339517
Pneumonitis 175.37 12.33 390 165643 60470 79517885
Malaise 173.05 12.33 488 165545 489381 79088974
Urticaria 172.34 12.33 85 165948 185116 79393239
Asthma 169.41 12.33 37 165996 135058 79443297
Diffuse large B-cell lymphoma 166.04 12.33 163 165870 11986 79566369
Injection site pain 166.01 12.33 34 165999 129804 79448551
Glossodynia 165.79 12.33 13 166020 103324 79475031
Cytokine release syndrome 165.43 12.33 281 165752 35717 79542638
Mantle cell lymphoma recurrent 165.39 12.33 58 165975 547 79577808
Venoocclusive liver disease 159.15 12.33 157 165876 11614 79566741
Fatigue 156.92 12.33 1214 164819 928513 78649842
Drug resistance 156.33 12.33 300 165733 41913 79536442
Pleural effusion 156.29 12.33 658 165375 144604 79433751
Epstein-Barr virus infection 154.87 12.33 170 165863 14246 79564109
Wheezing 152.40 12.33 29 166004 116635 79461720
Depression 146.60 12.33 141 165892 216649 79361706
Confusional state 145.92 12.33 275 165758 317722 79260633
Peripheral sensory neuropathy 145.78 12.33 157 165876 12876 79565479
Agranulocytosis 145.15 12.33 302 165731 44728 79533627
Respiratory failure 145.01 12.33 752 165281 180159 79398196
Discomfort 144.72 12.33 41 165992 125576 79452779
Drug interaction 144.05 12.33 417 165616 414766 79163589
Sinusitis 143.19 12.33 118 165915 195383 79382972
Hepatic enzyme increased 139.04 12.33 106 165927 182504 79395851
Psoriasis 138.99 12.33 13 166020 89574 79488781
Rhabdomyolysis 138.24 12.33 24 166009 103107 79475248
Anti-Muellerian hormone level decreased 138.14 12.33 34 165999 70 79578285
Neoplasm recurrence 137.72 12.33 94 165939 4120 79574235
Myocardial infarction 136.26 12.33 110 165923 184019 79394336
Blood cholesterol increased 135.81 12.33 10 166023 83710 79494645
Arthritis 135.14 12.33 36 165997 114844 79463511
Psoriatic arthropathy 133.46 12.33 7 166026 77992 79500363
Lymphopenia 133.16 12.33 233 165800 30324 79548031
Intestinal perforation 130.45 12.33 171 165862 17255 79561100
Hepatic failure 130.17 12.33 349 165684 60863 79517492
Post transplant lymphoproliferative disorder 129.81 12.33 139 165894 11325 79567030
Bronchopulmonary aspergillosis 127.09 12.33 192 165841 22102 79556253
Cytomegalovirus infection 127.06 12.33 277 165756 42367 79535988
Gene mutation 125.31 12.33 75 165958 2611 79575744
Metastases to lymph nodes 122.94 12.33 129 165904 10268 79568087
Loss of personal independence in daily activities 122.85 12.33 31 166002 102549 79475806
Candida infection 122.82 12.33 256 165777 37958 79540397
Lymphoma 122.51 12.33 166 165867 17294 79561061
Fibromyalgia 119.62 12.33 3 166030 64337 79514018
Mobility decreased 118.37 12.33 53 165980 122122 79456233
Hospitalisation 117.75 12.33 26 166007 94210 79484145
Drug intolerance 117.13 12.33 233 165800 263886 79314469
Injury 115.68 12.33 13 166020 77483 79500872
Osteoarthritis 115.54 12.33 21 166012 87288 79491067
Bronchitis 115.54 12.33 64 165969 130580 79447775
Metastasis 114.54 12.33 103 165930 6777 79571578
Venoocclusive disease 112.81 12.33 86 165947 4487 79573868
Staphylococcal bacteraemia 112.47 12.33 133 165900 12085 79566270
Bacteraemia 111.52 12.33 225 165808 32599 79545756
Bone pain 110.74 12.33 310 165723 55432 79522923
Aspergillus infection 110.62 12.33 166 165867 18995 79559360
Abdominal pain upper 110.33 12.33 185 165848 223634 79354721
Suicide attempt 109.63 12.33 20 166013 82912 79495443
Heart rate decreased 109.62 12.33 10 166023 70306 79508049
Irritable bowel syndrome 108.36 12.33 5 166028 62236 79516119
Cerebrovascular accident 107.31 12.33 99 165934 155193 79423162
Stomatitis 105.34 12.33 592 165441 146165 79432190
Injection site erythema 105.23 12.33 18 166015 78179 79500176
Stress 103.53 12.33 20 166013 79592 79498763
Myelopathy 103.16 12.33 82 165951 4551 79573804
Acute lymphocytic leukaemia recurrent 101.75 12.33 82 165951 4642 79573713
Metastases to peritoneum 100.83 12.33 79 165954 4293 79574062
Gait disturbance 99.09 12.33 175 165858 207331 79371024
Inappropriate schedule of product administration 98.63 12.33 80 165953 133548 79444807
Acute lymphocytic leukaemia 98.11 12.33 82 165951 4887 79573468
Tremor 97.05 12.33 127 165906 169956 79408399
Bradycardia 96.55 12.33 84 165949 135473 79442882
Salivary gland cancer 95.52 12.33 36 165997 424 79577931
Traumatic lung injury 94.34 12.33 60 165973 2331 79576024
Central nervous system lymphoma 94.22 12.33 59 165974 2230 79576125
Administration site extravasation 94.12 12.33 49 165984 1294 79577061
Herpes simplex 93.41 12.33 121 165912 12066 79566289
Breast cancer metastatic 93.37 12.33 102 165931 8500 79569855
Hypoglycaemia 92.42 12.33 48 165985 101546 79476809
Blood glucose increased 92.38 12.33 63 165970 114912 79463443
Cardiomyopathy acute 92.28 12.33 32 166001 291 79578064
Myeloid leukaemia 92.18 12.33 40 165993 693 79577662
Suicidal ideation 91.54 12.33 23 166010 76317 79502038
Blister 91.37 12.33 69 165964 119407 79458948
Blood pressure fluctuation 91.37 12.33 15 166018 67130 79511225
Ascites 91.34 12.33 355 165678 75207 79503148
Sweat gland tumour 90.70 12.33 36 165997 492 79577863
Musculoskeletal pain 90.70 12.33 50 165983 102304 79476051
Hypersensitivity 90.40 12.33 264 165769 261975 79316380
Computerised tomogram thorax abnormal 88.78 12.33 58 165975 2361 79575994
Chest pain 88.30 12.33 297 165736 282007 79296348
Osteonecrosis 88.13 12.33 198 165835 30897 79547458
BK virus infection 88.01 12.33 100 165933 8704 79569651
JC virus infection 84.94 12.33 68 165965 3813 79574542
Skin toxicity 84.07 12.33 95 165938 8219 79570136
Helicobacter infection 83.58 12.33 21 166012 69683 79508672
Pulmonary toxicity 81.96 12.33 117 165916 12797 79565558
Leukaemia 81.91 12.33 80 165953 5845 79572510
Injection site swelling 81.36 12.33 4 166029 47128 79531227
Refractory anaemia with an excess of blasts 81.02 12.33 39 165994 867 79577488
Pneumonia fungal 80.81 12.33 108 165925 11102 79567253
Myalgia 80.36 12.33 166 165867 185475 79392880
Lymphoma transformation 80.23 12.33 29 166004 301 79578054
Small intestinal obstruction 79.93 12.33 176 165857 27096 79551259
Incorrect dose administered 79.47 12.33 30 166003 76600 79501755
Gastrosplenic fistula 79.27 12.33 23 166010 108 79578247
Nephropathy toxic 79.16 12.33 148 165885 20271 79558084
Smooth muscle cell neoplasm 78.80 12.33 39 165994 923 79577432
Blood pressure systolic increased 78.75 12.33 21 166012 66965 79511390
Peripheral T-cell lymphoma unspecified 78.20 12.33 35 165998 655 79577700
Neutrophil count abnormal 77.63 12.33 62 165971 3464 79574891
Heart rate increased 77.59 12.33 82 165951 120642 79457713
Lower respiratory tract infection 77.35 12.33 93 165940 129127 79449228
Klebsiella infection 76.60 12.33 126 165907 15594 79562761
Impaired healing 75.97 12.33 44 165989 87611 79490744
5q minus syndrome 75.94 12.33 27 166006 266 79578089
C-reactive protein abnormal 75.07 12.33 7 166026 48360 79529995
Injection site pruritus 74.92 12.33 3 166030 42280 79536075
Enterococcal bacteraemia 74.15 12.33 57 165976 3011 79575344
Bone marrow disorder 74.07 12.33 59 165974 3284 79575071
Memory impairment 73.95 12.33 74 165959 111660 79466695
Cytomegalovirus infection reactivation 73.89 12.33 91 165942 8625 79569730
Pericarditis 73.73 12.33 65 165968 104171 79474184
Systemic candida 73.63 12.33 80 165953 6626 79571729
Anaplastic lymphoma kinase gene mutation 72.96 12.33 22 166011 121 79578234
Malignant transformation 72.87 12.33 40 165993 1178 79577177
Cardio-respiratory arrest 72.81 12.33 71 165962 108439 79469916
Injection site bruising 72.34 12.33 3 166030 40999 79537356
Infection reactivation 72.31 12.33 53 165980 2604 79575751
Viral haemorrhagic cystitis 72.20 12.33 48 165985 2013 79576342
Drug reaction with eosinophilia and systemic symptoms 72.09 12.33 22 166011 64222 79514133
Lung infiltration 71.88 12.33 152 165881 22760 79555595
Pneumonia 71.78 12.33 1840 164193 658406 78919949
Plasmacytoma 71.50 12.33 65 165968 4338 79574017
Computerised tomogram thorax 71.48 12.33 29 166004 421 79577934
Nasal congestion 71.37 12.33 35 165998 76517 79501838
Oedema peripheral 71.21 12.33 277 165756 252011 79326344
Hyperhidrosis 71.19 12.33 129 165904 151363 79426992
Injection site reaction 70.73 12.33 14 166019 54771 79523584
Balance disorder 70.70 12.33 61 165972 98796 79479559
Remission not achieved 70.66 12.33 28 166005 381 79577974
Angioedema 70.53 12.33 35 165998 76000 79502355
Cytogenetic abnormality 70.23 12.33 38 165995 1087 79577268
Metastases to central nervous system 70.22 12.33 124 165909 16251 79562104
Strongyloidiasis 70.16 12.33 61 165972 3837 79574518
Condition aggravated 69.67 12.33 687 165346 500437 79077918
Acute hepatitis B 69.15 12.33 29 166004 460 79577895
Breast cancer recurrent 69.10 12.33 54 165979 2923 79575432
Illness 68.91 12.33 8 166025 46503 79531852
Adverse drug reaction 68.83 12.33 26 166007 66366 79511989
Chronic obstructive pulmonary disease 68.35 12.33 47 165986 85372 79492983
Nephrolithiasis 68.00 12.33 14 166019 53277 79525078
End stage renal disease 67.89 12.33 104 165929 12116 79566239
Loss of consciousness 67.87 12.33 156 165877 167787 79410568
Encephalopathy 67.59 12.33 299 165734 67098 79511257
Sleep disorder 67.43 12.33 48 165985 85629 79492726
Chronic myeloid leukaemia 67.29 12.33 58 165975 3606 79574749
Varicella zoster virus infection 67.15 12.33 63 165970 4378 79573977
Fluid retention 66.49 12.33 31 166002 69778 79508577
Ventricular hypokinesia 66.28 12.33 89 165944 9190 79569165
Gastrointestinal toxicity 66.08 12.33 83 165950 8026 79570329
Road traffic accident 65.99 12.33 7 166026 43657 79534698
Joint stiffness 65.86 12.33 5 166028 40825 79537530
Hallucination 64.94 12.33 50 165983 85695 79492660
Pericardial effusion 64.90 12.33 228 165805 46009 79532346
Respiratory arrest 64.05 12.33 20 166013 57530 79520825
Alopecia 64.02 12.33 256 165777 231099 79347256
Dyspnoea 63.84 12.33 1331 164702 855694 78722661
Aggression 63.77 12.33 14 166019 50944 79527411
Plasma cell leukaemia 63.55 12.33 42 165991 1744 79576611
Thrombotic microangiopathy 63.50 12.33 134 165899 20035 79558320
Ileus paralytic 62.30 12.33 88 165945 9532 79568823
COVID-19 pneumonia 61.83 12.33 165 165868 28684 79549671
Pneumocystis jirovecii infection 61.83 12.33 50 165983 2844 79575511
Metastases to breast 61.40 12.33 23 166010 266 79578089
Serotonin syndrome 61.39 12.33 10 166023 45017 79533338
Cardiac dysfunction 61.39 12.33 58 165975 4066 79574289
Coronary artery disease 60.94 12.33 30 166003 65444 79512911
International normalised ratio increased 60.92 12.33 52 165981 84669 79493686
Dry mouth 60.92 12.33 56 165977 87963 79490392
Recurrent cancer 60.68 12.33 48 165985 2645 79575710
Organising pneumonia 60.63 12.33 93 165940 10846 79567509
Drug clearance decreased 59.76 12.33 52 165981 3275 79575080
Colitis 59.55 12.33 306 165727 73001 79505354
Pneumatosis intestinalis 59.48 12.33 70 165963 6327 79572028
Escherichia infection 59.41 12.33 122 165911 17895 79560460
Premature menopause 59.36 12.33 28 166005 594 79577761
Gastrooesophageal reflux disease 58.26 12.33 79 165954 104167 79474188
Extravasation 58.24 12.33 54 165979 3696 79574659
Type 2 diabetes mellitus 58.17 12.33 23 166010 57099 79521256
Epstein-Barr virus associated lymphoma 57.64 12.33 33 166000 1056 79577299
Blood creatine phosphokinase increased 57.52 12.33 33 166000 66057 79512298
Vision blurred 57.44 12.33 82 165951 105816 79472539
Peripheral motor neuropathy 57.22 12.33 51 165982 3316 79575039
Neck pain 57.09 12.33 44 165989 75373 79502982
Chemotherapy 56.96 12.33 39 165994 1718 79576637
Product prescribing error 56.71 12.33 12 166021 44801 79533554
Palpitations 56.67 12.33 111 165922 126499 79451856
Toxic cardiomyopathy 56.59 12.33 24 166009 392 79577963
Escherichia bacteraemia 56.41 12.33 69 165964 6493 79571862
Bursitis 56.13 12.33 5 166028 35839 79542516
Hypoaesthesia 55.82 12.33 189 165844 179163 79399192
Migraine 55.58 12.33 60 165973 87433 79490922
Neoplasm 55.53 12.33 81 165952 9035 79569320
Post embolisation syndrome 55.52 12.33 16 166017 73 79578282
Agitation 55.29 12.33 76 165957 99639 79478716
Diarrhoea 54.46 12.33 1407 164626 879082 78699273
Mucosal toxicity 54.18 12.33 26 166007 574 79577781
Ovarian failure 54.17 12.33 27 166006 649 79577706
Drug withdrawal syndrome 53.94 12.33 5 166028 34713 79543642
Staphylococcal sepsis 53.70 12.33 104 165929 14622 79563733
Visual impairment 53.35 12.33 68 165965 92063 79486292
Swollen tongue 52.66 12.33 12 166021 42558 79535797
Hepatitis E 52.28 12.33 46 165987 2940 79575415
Clostridium difficile colitis 52.23 12.33 167 165866 32116 79546239
Bone marrow infiltration 51.65 12.33 27 166006 719 79577636
Enterococcal infection 51.59 12.33 106 165927 15554 79562801
Pseudomonas infection 51.48 12.33 126 165907 20777 79557578
Rash pruritic 51.46 12.33 44 165989 71585 79506770
Atelectasis 51.40 12.33 166 165867 32091 79546264
Amnesia 51.38 12.33 34 165999 63023 79515332
Accidental overdose 51.34 12.33 10 166023 39571 79538784
Cataract 51.29 12.33 33 166000 62087 79516268
Joint range of motion decreased 51.16 12.33 5 166028 33277 79545078
Adverse event 51.08 12.33 31 166002 60183 79518172
Chloroma 50.85 12.33 27 166006 743 79577612
Swelling face 50.85 12.33 44 165989 71168 79507187
Folliculitis 50.60 12.33 26 166007 55354 79523001
B-cell lymphoma refractory 50.50 12.33 17 166016 140 79578215
Gait inability 50.45 12.33 30 166003 58887 79519468
Limb discomfort 50.33 12.33 5 166028 32845 79545510
Metastases to skin 50.31 12.33 36 165997 1703 79576652
Metastases to spine 49.96 12.33 53 165980 4271 79574084
Toxic erythema of chemotherapy 49.51 12.33 19 166014 236 79578119
Hypertransaminasaemia 49.47 12.33 89 165944 11835 79566520
Anal inflammation 49.36 12.33 33 166000 1397 79576958
Ototoxicity 48.65 12.33 46 165987 3228 79575127
Plasma cell myeloma recurrent 48.63 12.33 56 165977 4945 79573410
Acute myelomonocytic leukaemia 48.46 12.33 20 166013 304 79578051
Ear infection 48.42 12.33 7 166026 34425 79543930
Sopor 48.11 12.33 6 166027 33004 79545351
Vasogenic cerebral oedema 48.07 12.33 33 166000 1460 79576895
Device related infection 48.04 12.33 169 165864 34125 79544230
Cutaneous calcification 47.94 12.33 16 166017 128 79578227
Lip swelling 47.76 12.33 13 166020 40898 79537457
Surgery 47.65 12.33 6 166027 32760 79545595
Blood pressure decreased 47.34 12.33 84 165949 99382 79478973
Weight decreased 47.21 12.33 492 165541 354706 79223649
Escherichia sepsis 46.69 12.33 72 165961 8436 79569919
Pneumonia klebsiella 46.49 12.33 55 165978 4999 79573356
Therapy non-responder 46.22 12.33 340 165693 91965 79486390
Injection site haemorrhage 46.15 12.33 3 166030 27867 79550488
Hypoxia 45.96 12.33 370 165663 102873 79475482
Neutropenic infection 45.76 12.33 39 165994 2388 79575967
Treatment noncompliance 45.62 12.33 26 166007 52242 79526113
Unevaluable event 45.25 12.33 30 166003 55555 79522800
Aplastic anaemia 45.24 12.33 109 165924 17796 79560559
Colony stimulating factor therapy 45.18 12.33 22 166011 502 79577853
Heart rate irregular 45.13 12.33 7 166026 32672 79545683
Lymphadenitis 45.05 12.33 52 165981 4603 79573752
Dry skin 45.02 12.33 45 165988 67950 79510405
Philadelphia chromosome positive 45.02 12.33 24 166009 666 79577689
B-cell lymphoma 44.99 12.33 60 165973 6155 79572200
Therapy interrupted 44.95 12.33 6 166027 31335 79547020
Transient ischaemic attack 44.88 12.33 27 166006 52668 79525687
Blood stem cell transplant failure 44.75 12.33 22 166011 513 79577842
Immune effector cell-associated neurotoxicity syndrome 44.72 12.33 58 165975 5790 79572565
Hepatotoxicity 44.27 12.33 218 165815 51134 79527221
Withdrawal syndrome 44.15 12.33 3 166030 26851 79551504
Depressed level of consciousness 43.89 12.33 84 165949 96568 79481787
Labelled drug-drug interaction medication error 42.91 12.33 4 166029 27646 79550709
Ileus 42.78 12.33 136 165897 26075 79552280
Medication error 42.57 12.33 48 165985 68594 79509761
Myelitis 42.20 12.33 37 165996 2354 79576001
Nervousness 42.18 12.33 9 166024 33406 79544949
Abdominal neoplasm 42.05 12.33 22 166011 587 79577768
Lactic acidosis 41.71 12.33 51 165982 70308 79508047
Hypertriglyceridaemia 41.69 12.33 86 165947 12654 79565701
Limb injury 41.53 12.33 6 166027 29522 79548833
Pseudomonal bacteraemia 41.46 12.33 41 165992 3041 79575314
Clostridium bacteraemia 41.35 12.33 19 166014 379 79577976
SARS-CoV-2 test negative 41.09 12.33 29 166004 1342 79577013
Metastases to bone marrow 41.09 12.33 24 166009 798 79577557
Perineal necrosis 41.00 12.33 14 166019 121 79578234
Alveolitis 40.97 12.33 47 165986 4133 79574222
Alveolar soft part sarcoma 40.95 12.33 13 166020 87 79578268
Endocarditis noninfective 40.56 12.33 16 166017 215 79578140
Clonal evolution 40.49 12.33 16 166017 216 79578139
Fanconi syndrome 40.30 12.33 39 165994 2817 79575538
Clostridium difficile infection 40.27 12.33 186 165847 42499 79535856
Refractory cancer 40.22 12.33 16 166017 220 79578135
Liver function test abnormal 40.08 12.33 45 165988 64430 79513925
Osteosarcoma recurrent 39.94 12.33 11 166022 41 79578314
Red blood cell sedimentation rate increased 39.89 12.33 23 166010 45919 79532436
Head injury 39.81 12.33 14 166019 37355 79541000
Electrocardiogram QT prolonged 39.79 12.33 80 165953 90306 79488049
Gastrointestinal fungal infection 39.34 12.33 20 166013 502 79577853
Hydrothorax 39.31 12.33 29 166004 1439 79576916
Gastritis bacterial 39.22 12.33 18 166015 358 79577997
Rhinorrhoea 39.21 12.33 61 165972 76013 79502342
West Nile viral infection 39.18 12.33 25 166008 977 79577378
Osteosarcoma metastatic 39.13 12.33 11 166022 45 79578310
Tooth malformation 38.84 12.33 14 166019 144 79578211
Acute monocytic leukaemia 38.73 12.33 20 166013 519 79577836
Peripheral sensorimotor neuropathy 38.57 12.33 39 165994 2971 79575384
Mass 38.53 12.33 101 165932 17371 79560984
Ganglioneuroblastoma 38.47 12.33 10 166023 28 79578327
Therapy cessation 38.45 12.33 15 166018 37547 79540808
Gastric stenosis 38.42 12.33 14 166019 149 79578206
Influenza like illness 38.41 12.33 56 165977 71651 79506704
Capillary leak syndrome 38.25 12.33 44 165989 3881 79574474
Gastric disorder 38.23 12.33 15 166018 37418 79540937
Blast cells present 38.19 12.33 24 166009 913 79577442
Haematopoietic stem cell mobilisation 38.06 12.33 15 166018 201 79578154
Synovial sarcoma 37.97 12.33 12 166021 79 79578276
Flagellate dermatitis 37.97 12.33 16 166017 257 79578098
Leukoencephalopathy 37.89 12.33 63 165970 7866 79570489
Cytomegalovirus viraemia 37.86 12.33 83 165950 12738 79565617
Eczema 37.54 12.33 19 166014 40799 79537556
Oxygen saturation decreased 37.47 12.33 140 165893 128907 79449448
Subdural hygroma 36.90 12.33 19 166014 490 79577865
Invasive ductal breast carcinoma 36.83 12.33 53 165980 5839 79572516
Primary cardiac lymphoma 36.74 12.33 9 166024 18 79578337
Oedema 36.53 12.33 127 165906 119453 79458902
Unintentional medical device removal 36.48 12.33 61 165972 7651 79570704
White blood cell count abnormal 36.38 12.33 52 165981 5693 79572662
Emotional distress 36.17 12.33 19 166014 39950 79538405
Metastases to meninges 36.16 12.33 41 165992 3560 79574795
Nasal abscess 36.11 12.33 14 166019 179 79578176
Glioma 36.04 12.33 20 166013 602 79577753
Hyperkalaemia 35.96 12.33 120 165913 114278 79464077
Vocal cord paralysis 35.89 12.33 35 165998 2552 79575803
Intertrigo 35.65 12.33 22 166011 810 79577545
Gastric perforation 35.60 12.33 43 165990 3994 79574361
Product administration error 35.56 12.33 11 166022 31835 79546520
Influenza 35.46 12.33 144 165889 129462 79448893
Metastases to spleen 35.39 12.33 20 166013 624 79577731
Burning sensation 35.28 12.33 42 165991 58590 79519765
Frequent bowel movements 35.21 12.33 9 166024 29530 79548825
Multiple sclerosis 35.18 12.33 3 166030 22279 79556076
Pneumothorax spontaneous 35.11 12.33 27 166006 1427 79576928
Rhinovirus infection 35.11 12.33 61 165972 7892 79570463
Vertigo 35.03 12.33 56 165977 69026 79509329
Nail pigmentation 34.96 12.33 16 166017 316 79578039
Metastases to retroperitoneum 34.95 12.33 17 166016 387 79577968
Urinary tract infection 34.94 12.33 384 165649 274128 79304227
Haemorrhage 34.92 12.33 87 165946 91031 79487324
Eosinophilia 34.90 12.33 26 166007 45319 79533036
Necrotising gastritis 34.73 12.33 11 166022 73 79578282
Amniotic fluid index decreased 34.52 12.33 8 166025 11 79578344
Renal tubular disorder 34.35 12.33 54 165979 6432 79571923
Enterococcal sepsis 34.35 12.33 35 165998 2691 79575664
Hypertension 34.24 12.33 484 165549 330508 79247847
Procedural pain 34.12 12.33 4 166029 23080 79555275
Central nervous system enteroviral infection 34.11 12.33 11 166022 78 79578277
Autoimmune neutropenia 33.94 12.33 19 166014 582 79577773
Cerebral venous sinus thrombosis 33.68 12.33 32 166001 2259 79576096
Lymphocytosis 33.50 12.33 45 165988 4648 79573707
Prescribed underdose 33.30 12.33 10 166023 29504 79548851
Abortion spontaneous 33.29 12.33 10 166023 29497 79548858
Inflammation 33.28 12.33 93 165940 93660 79484695
Ventricular dysfunction 33.09 12.33 51 165982 5972 79572383
Autoimmune lymphoproliferative syndrome 32.86 12.33 13 166020 176 79578179
Hyperferritinaemia 32.84 12.33 20 166013 719 79577636
Osteosarcoma 32.58 12.33 16 166017 372 79577983
Nightmare 32.57 12.33 7 166026 25854 79552501
Dementia 32.47 12.33 6 166027 24653 79553702
Product quality issue 32.43 12.33 15 166018 33925 79544430
Chronic myelomonocytic leukaemia 32.36 12.33 21 166012 845 79577510
Mucormycosis 32.35 12.33 61 165972 8408 79569947
Splenic marginal zone lymphoma 32.29 12.33 10 166023 61 79578294
Peripartum cardiomyopathy 32.18 12.33 12 166021 137 79578218
Pseudomonal sepsis 32.14 12.33 51 165982 6123 79572232
Acute hepatic failure 32.02 12.33 136 165897 29977 79548378
Orthostatic hypotension 31.95 12.33 42 165991 56122 79522233
Systemic toxicity 31.94 12.33 12 166021 140 79578215
Feeling hot 31.65 12.33 47 165986 59687 79518668
Hepatitis C RNA increased 31.53 12.33 16 166017 400 79577955
Large intestinal ulcer perforation 31.49 12.33 10 166023 67 79578288
Unresponsive to stimuli 31.45 12.33 42 165991 55746 79522609
Cholelithiasis 31.40 12.33 38 165995 52626 79525729
Dysgeusia 31.27 12.33 44 165989 57133 79521222
Toxicity to various agents 31.15 12.33 655 165378 420885 79157470
Secondary immunodeficiency 31.09 12.33 36 165997 3198 79575157
Depressed mood 31.06 12.33 33 166000 48447 79529908
Renal-limited thrombotic microangiopathy 31.06 12.33 12 166021 152 79578203
Blood pressure diastolic decreased 31.04 12.33 12 166021 30204 79548151
Extrapyramidal disorder 31.00 12.33 5 166028 22674 79555681
Invasive lobular breast carcinoma 30.97 12.33 19 166014 692 79577663
Eye pain 30.97 12.33 20 166013 37558 79540797
Haematoma 30.76 12.33 38 165995 52157 79526198
Colitis ulcerative 30.73 12.33 17 166016 34725 79543630
Squamous cell carcinoma of the oral cavity 30.66 12.33 17 166016 511 79577844
Muscle rigidity 30.53 12.33 3 166030 19879 79558476
Death 30.37 12.33 923 165110 565591 79012764
Meningitis cryptococcal 30.36 12.33 37 165996 3469 79574886
Pulmonary alveolar haemorrhage 30.30 12.33 71 165962 11386 79566969
Therapy responder 30.24 12.33 16 166017 437 79577918
Left ventricular dilatation 30.05 12.33 22 166011 1079 79577276
Retinal haemorrhage 29.92 12.33 58 165975 8159 79570196
Irritability 29.89 12.33 25 166008 41119 79537236
Fungal oesophagitis 29.85 12.33 21 166012 967 79577388
Respiratory distress 29.83 12.33 216 165817 58123 79520232
Eye swelling 29.81 12.33 9 166024 26459 79551896
Flatulence 29.77 12.33 27 166006 42697 79535658
Sciatica 29.76 12.33 16 166017 33206 79545149
Diabetes mellitus inadequate control 29.69 12.33 7 166026 24257 79554098
Localised infection 29.63 12.33 21 166012 37554 79540801
Hypercholesterolaemia 29.60 12.33 6 166027 23089 79555266
Paraparesis 29.52 12.33 38 165995 3765 79574590
Kidney infection 29.46 12.33 5 166028 21846 79556509
Metastases to pleura 29.35 12.33 25 166008 1529 79576826
Osteomyelitis bacterial 29.31 12.33 16 166017 466 79577889
T-cell type acute leukaemia 29.28 12.33 12 166021 179 79578176
Blood pressure diastolic abnormal 29.22 12.33 3 166030 19199 79559156
Abnormal behaviour 29.19 12.33 20 166013 36401 79541954
Candida pneumonia 29.16 12.33 18 166015 663 79577692
Respiratory syncytial virus infection 29.06 12.33 62 165971 9340 79569015
Acute lung injury 28.95 12.33 34 165999 3066 79575289
Hepatosplenic candidiasis 28.95 12.33 17 166016 571 79577784
Amenorrhoea 28.88 12.33 55 165978 7637 79570718
T-cell lymphoma 28.88 12.33 23 166010 1280 79577075
VIth nerve paresis 28.85 12.33 11 166022 134 79578221
Carotid intima-media thickness increased 28.83 12.33 10 166023 91 79578264
Bacterial sepsis 28.80 12.33 57 165976 8141 79570214
Hip fracture 28.77 12.33 14 166019 30747 79547608
Pathogen resistance 28.71 12.33 80 165953 14262 79564093
Dry eye 28.65 12.33 21 166012 36910 79541445
Tumour necrosis 28.55 12.33 27 166006 1895 79576460
Leukaemia cutis 28.52 12.33 12 166021 192 79578163
Maternal exposure during pregnancy 28.48 12.33 167 165866 136371 79441984
Sinus disorder 28.46 12.33 6 166027 22458 79555897
Blood urine present 28.43 12.33 5 166028 21292 79557063
Anastomotic leak 28.43 12.33 21 166012 1044 79577311
Throat irritation 28.39 12.33 26 166007 40920 79537435
Respiratory depression 28.34 12.33 11 166022 27619 79550736
Mesenteric abscess 28.28 12.33 11 166022 142 79578213
Meningitis tuberculous 28.28 12.33 22 166011 1183 79577172
Bone lesion 28.24 12.33 47 165986 5872 79572483
Respiratory tract congestion 28.19 12.33 4 166029 19950 79558405
Pleuroparenchymal fibroelastosis 28.14 12.33 11 166022 144 79578211
Photosensitivity reaction 28.12 12.33 5 166028 21122 79557233
Coma 28.05 12.33 111 165922 100538 79477817
Body temperature decreased 28.04 12.33 16 166017 32129 79546226
Blood potassium increased 27.87 12.33 13 166020 29262 79549093
Chemotherapeutic drug level increased 27.84 12.33 14 166019 343 79578012
Panic attack 27.70 12.33 8 166025 24208 79554147
Sneezing 27.68 12.33 4 166029 19679 79558676
Rectal haemorrhage 27.59 12.33 75 165958 76225 79502130
Pyloric stenosis 27.58 12.33 16 166017 525 79577830
Myeloproliferative neoplasm 27.53 12.33 20 166013 969 79577386
COVID-19 27.37 12.33 471 165562 157203 79421152
Premature delivery 27.33 12.33 109 165924 23358 79554997
Dysaesthesia 27.32 12.33 46 165987 5802 79572553
Hallucination, auditory 27.32 12.33 5 166028 20688 79557667
Neurological symptom 27.24 12.33 58 165975 8725 79569630
Immunosuppression 27.21 12.33 73 165960 12730 79565625
Adrenocortical carcinoma 27.18 12.33 9 166024 70 79578285
Stem cell transplant 27.18 12.33 36 165997 3668 79574687
Dyspepsia 27.14 12.33 125 165908 108562 79469793
Gallbladder disorder 27.03 12.33 4 166029 19336 79559019
Pregnancy 27.03 12.33 11 166022 26840 79551515
Viral load increased 26.98 12.33 32 166001 2916 79575439
Haematochezia 26.82 12.33 93 165940 87552 79490803
Positron emission tomogram abnormal 26.81 12.33 14 166019 372 79577983
Chronic hepatitis 26.77 12.33 23 166010 1424 79576931
Iron deficiency anaemia 26.70 12.33 10 166023 25662 79552693
Lymphadenopathy mediastinal 26.69 12.33 39 165994 4357 79573998
Back pain 26.65 12.33 459 165574 303721 79274634
Leukoerythroblastosis 26.60 12.33 13 166020 299 79578056
Klebsiella bacteraemia 26.44 12.33 32 166001 2978 79575377
Hot flush 26.42 12.33 46 165987 54831 79523524
Rhabdomyosarcoma recurrent 26.29 12.33 10 166023 121 79578234
Restlessness 26.21 12.33 35 165998 46457 79531898
Hepatitis B DNA increased 26.21 12.33 18 166015 797 79577558
Ankle brachial index decreased 26.13 12.33 9 166024 80 79578275
Body dysmorphic disorder 26.10 12.33 13 166020 312 79578043
Disorder of orbit 26.07 12.33 10 166023 124 79578231
Poisoning 26.02 12.33 10 166023 25262 79553093
Device related thrombosis 26.02 12.33 30 166003 2653 79575702
Acute respiratory distress syndrome 26.00 12.33 169 165864 43898 79534457
Hyperpyrexia 25.95 12.33 46 165987 6046 79572309
Infection 25.95 12.33 673 165360 241039 79337316
Leukaemic lymphoma 25.94 12.33 9 166024 82 79578273
Biliary-bronchial fistula 25.88 12.33 5 166028 0 79578355
Pulse waveform abnormal 25.84 12.33 9 166024 83 79578272
Mood swings 25.83 12.33 5 166028 19875 79558480
Epstein Barr virus positive mucocutaneous ulcer 25.81 12.33 18 166015 817 79577538
Hypersomnia 25.73 12.33 8 166025 23078 79555277
Thyroid dermatopathy 25.65 12.33 7 166026 25 79578330
Sleep apnoea syndrome 25.48 12.33 23 166010 36455 79541900
Pyomyositis 25.45 12.33 16 166017 609 79577746
Grip strength decreased 25.43 12.33 7 166026 21862 79556493
Cerebellar haemangioma 25.37 12.33 9 166024 88 79578267
Tendonitis 25.26 12.33 9 166024 23821 79554534
Embolism 25.10 12.33 75 165958 13907 79564448
Recall phenomenon 25.05 12.33 20 166013 1117 79577238
Disturbance in attention 24.99 12.33 42 165991 50759 79527596
Ovarian cancer recurrent 24.97 12.33 14 166019 430 79577925
Ovarian epithelial cancer recurrent 24.83 12.33 6 166027 11 79578344
Poor venous access 24.81 12.33 4 166029 18145 79560210
Ureteric compression 24.76 12.33 12 166021 271 79578084
Subclavian vein thrombosis 24.72 12.33 28 166005 2429 79575926
Glycosylated haemoglobin increased 24.70 12.33 5 166028 19255 79559100
Cutaneous T-cell lymphoma recurrent 24.65 12.33 8 166025 58 79578297
Enterovirus infection 24.54 12.33 25 166008 1922 79576433
Upper limb fracture 24.47 12.33 4 166029 17963 79560392
Cytomegalovirus hepatitis 24.47 12.33 17 166016 767 79577588
Injection site rash 24.45 12.33 4 166029 17950 79560405
Tooth disorder 24.44 12.33 12 166021 26221 79552134
Laboratory test abnormal 24.41 12.33 14 166019 28034 79550321
Hepatic infarction 24.33 12.33 18 166015 897 79577458
Oesophageal candidiasis 24.24 12.33 57 165976 9161 79569194
Blood HIV RNA increased 24.23 12.33 24 166009 1784 79576571
Vena cava thrombosis 24.18 12.33 30 166003 2865 79575490
Muscular weakness 24.13 12.33 216 165817 160513 79417842
Combined immunodeficiency 24.11 12.33 9 166024 103 79578252
Abdominal distension 24.08 12.33 148 165885 119502 79458853
Hypoalbuminaemia 24.07 12.33 98 165935 21199 79557156
Drug ineffective 24.05 12.33 2585 163448 1078328 78500027
Acute biphenotypic leukaemia 24.00 12.33 10 166023 156 79578199
Intestinal atresia 23.97 12.33 8 166025 64 79578291
Chromosomal deletion 23.88 12.33 10 166023 158 79578197
Fear 23.83 12.33 8 166025 21978 79556377
Marginal zone lymphoma recurrent 23.77 12.33 7 166026 35 79578320
Osteoporosis 23.72 12.33 48 165985 54064 79524291
Glioblastoma multiforme 23.70 12.33 20 166013 1208 79577147
Gastroenteritis viral 23.68 12.33 11 166022 24820 79553535
Stevens-Johnson syndrome 23.62 12.33 28 166005 39138 79539217
Encephalitis viral 23.61 12.33 28 166005 2551 79575804
Heart rate abnormal 23.60 12.33 44 165989 6013 79572342
Skin mass 23.58 12.33 52 165981 8011 79570344
Renal disorder 23.43 12.33 32 166001 42073 79536282
Sputum discoloured 23.41 12.33 8 166025 21735 79556620
Streptococcal bacteraemia 23.37 12.33 33 166000 3573 79574782
Disseminated intravascular coagulation 23.35 12.33 141 165892 35701 79542654
Faeces discoloured 23.33 12.33 16 166017 29111 79549244
Myasthenia gravis crisis 23.33 12.33 19 166014 1092 79577263
Movement disorder 23.17 12.33 14 166019 27245 79551110
Clonal haematopoiesis 23.14 12.33 7 166026 39 79578316
Pneumonia adenoviral 23.12 12.33 14 166019 498 79577857
Pneumonia cytomegaloviral 23.10 12.33 39 165994 4930 79573425
Skin laceration 23.08 12.33 16 166017 28946 79549409
Splenomegaly 23.06 12.33 95 165938 20659 79557696
Sarcoma metastatic 23.04 12.33 8 166025 73 79578282
Chromosome analysis abnormal 22.96 12.33 11 166022 242 79578113
Cryptosporidiosis infection 22.93 12.33 16 166017 727 79577628
Hernia 22.79 12.33 4 166029 17055 79561300
Deep vein thrombosis 22.74 12.33 366 165667 120553 79457802
Infusion site streaking 22.72 12.33 14 166019 514 79577841
Paraesthesia 22.68 12.33 246 165787 176077 79402278
Erythropenia 22.65 12.33 13 166020 418 79577937
Small intestinal perforation 22.60 12.33 31 166002 3266 79575089
Delirium 22.53 12.33 95 165938 84532 79493823
Humoral immune defect 22.51 12.33 13 166020 423 79577932
Sinus polyp 22.48 12.33 14 166019 524 79577831
Cerebral haemangioma 22.48 12.33 9 166024 126 79578229
Intussusception 22.46 12.33 19 166014 1151 79577204
Mucosal disorder 22.44 12.33 32 166001 3496 79574859
Joint effusion 22.43 12.33 5 166028 18009 79560346
Device electrical impedance issue 22.43 12.33 5 166028 5 79578350
Oral fungal infection 22.42 12.33 33 166000 3710 79574645
Device pacing issue 22.41 12.33 9 166024 127 79578228
Granulocyte count decreased 22.39 12.33 23 166010 1785 79576570
Pulmonary embolism 22.39 12.33 491 165542 171163 79407192
Haemoglobin abnormal 22.36 12.33 47 165986 7007 79571348
B-cell type acute leukaemia 22.36 12.33 14 166019 529 79577826
Metastases to abdominal wall 22.35 12.33 10 166023 187 79578168
Rash erythematous 22.26 12.33 55 165978 57714 79520641
Creatinine renal clearance decreased 22.25 12.33 6 166027 18996 79559359
Refractory cytopenia with multilineage dysplasia 22.24 12.33 11 166022 260 79578095
Cardiac failure acute 22.11 12.33 88 165945 18841 79559514
Venous thrombosis 22.08 12.33 47 165986 7069 79571286
Soft tissue neoplasm 22.05 12.33 8 166025 84 79578271
Ageusia 22.00 12.33 4 166029 16628 79561727
Lip dry 21.99 12.33 3 166030 15415 79562940
Sinus congestion 21.98 12.33 7 166026 19889 79558466
Leukaemia recurrent 21.98 12.33 28 166005 2746 79575609
Nodular regenerative hyperplasia 21.92 12.33 20 166013 1341 79577014
Drug ineffective for unapproved indication 21.92 12.33 182 165851 51056 79527299
Coronary artery occlusion 21.80 12.33 3 166030 15312 79563043
Oophoritis 21.80 12.33 8 166025 87 79578268
Cellulitis gangrenous 21.79 12.33 11 166022 272 79578083
Obstructive airways disorder 21.78 12.33 20 166013 31439 79546916
Mediastinum neoplasm 21.64 12.33 8 166025 89 79578266
Tissue infiltration 21.60 12.33 15 166018 676 79577679
Fungal infection 21.59 12.33 155 165878 41593 79536762
Blood glucose decreased 21.57 12.33 14 166019 26220 79552135
Clostridium colitis 21.46 12.33 28 166005 2811 79575544
Helicobacter sepsis 21.45 12.33 6 166027 24 79578331
Taeniasis 21.42 12.33 7 166026 52 79578303
Encephalitis enteroviral 21.39 12.33 9 166024 144 79578211
Carpal tunnel syndrome 21.35 12.33 7 166026 19521 79558834
Follicular lymphoma 21.25 12.33 12 166021 374 79577981
Human rhinovirus test positive 21.13 12.33 13 166020 476 79577879
Blood calcium decreased 21.13 12.33 21 166012 31798 79546557
Vascular injury 21.11 12.33 18 166015 1103 79577252
Adenocarcinoma gastric 21.09 12.33 22 166011 1739 79576616
Geotrichum infection 21.07 12.33 17 166016 964 79577391
Enterovirus test positive 21.01 12.33 11 166022 294 79578061
Diabetic ketoacidosis 21.01 12.33 24 166009 34098 79544257
Obstruction gastric 20.99 12.33 22 166011 1748 79576607
Epstein-Barr virus associated lymphoproliferative disorder 20.96 12.33 31 166002 3501 79574854
Metastases to soft tissue 20.89 12.33 14 166019 595 79577760
Abdominal abscess 20.89 12.33 46 165987 7081 79571274
Lentigo 20.84 12.33 13 166020 488 79577867
Transformation to acute myeloid leukaemia 20.83 12.33 17 166016 980 79577375
Rhabdomyosarcoma 20.79 12.33 9 166024 155 79578200
Herpes simplex encephalitis 20.75 12.33 15 166018 721 79577634
Azoospermia 20.74 12.33 9 166024 156 79578199
Mucoepidermoid carcinoma of salivary gland 20.73 12.33 8 166025 101 79578254
Cerebral aspergillosis 20.73 12.33 22 166011 1774 79576581
Quadriplegia 20.67 12.33 30 166003 3330 79575025
Blood potassium decreased 20.61 12.33 41 165992 46471 79531884
Neuroendocrine carcinoma of the skin 20.58 12.33 19 166014 1293 79577062
Osteolysis 20.51 12.33 35 165998 4463 79573892
Acute lymphocytic leukaemia refractory 20.48 12.33 9 166024 161 79578194
Miosis 20.45 12.33 4 166029 15785 79562570
Hyperbilirubinaemia 20.36 12.33 103 165930 24415 79553940
Poor quality sleep 20.27 12.33 11 166022 22711 79555644
Neurological decompensation 20.27 12.33 38 165995 5215 79573140
Joint neoplasm 20.25 12.33 7 166026 63 79578292
Urinary retention 20.22 12.33 56 165977 56574 79521781
Product use issue 20.18 12.33 576 165457 209246 79369109
Candida endophthalmitis 20.18 12.33 9 166024 167 79578188
Listeria sepsis 20.11 12.33 15 166018 757 79577598
B precursor type acute leukaemia 20.09 12.33 12 166021 416 79577939
Drug level decreased 20.08 12.33 3 166030 14399 79563956
Uterine enlargement 20.06 12.33 16 166017 892 79577463
Chylothorax 20.06 12.33 15 166018 760 79577595
Glaucoma 20.05 12.33 8 166025 19753 79558602
Fungaemia 19.99 12.33 35 165998 4556 79573799
Liver abscess 19.97 12.33 41 165992 6013 79572342
Metabolic acidosis 19.96 12.33 96 165937 82433 79495922
Respiratory rate increased 19.94 12.33 10 166023 21590 79556765
Campylobacter gastroenteritis 19.94 12.33 19 166014 1346 79577009
Retroperitoneal mass 19.93 12.33 10 166023 244 79578111
Diverticulitis 19.92 12.33 41 165992 45895 79532460
Blood loss anaemia 19.92 12.33 4 166029 15494 79562861
Hepatosplenomegaly 19.90 12.33 41 165992 6028 79572327
Respiratory tract infection fungal 19.88 12.33 18 166015 1195 79577160
Duodenal stenosis 19.85 12.33 15 166018 772 79577583
Metastases to pelvis 19.83 12.33 14 166019 648 79577707
Vulvovaginal inflammation 19.82 12.33 13 166020 533 79577822
Trichodysplasia spinulosa 19.77 12.33 15 166018 777 79577578
Primary immunodeficiency syndrome 19.69 12.33 7 166026 69 79578286
Radiation necrosis 19.66 12.33 12 166021 433 79577922
Basal ganglion degeneration 19.59 12.33 12 166021 436 79577919
Meningoencephalitis viral 19.56 12.33 12 166021 437 79577918
Seasonal allergy 19.55 12.33 5 166028 16401 79561954
Haemoptysis 19.54 12.33 56 165977 55943 79522412
Rotator cuff syndrome 19.51 12.33 3 166030 14092 79564263
Liver function test increased 19.46 12.33 33 166000 39740 79538615
Metastases to eye 19.45 12.33 10 166023 257 79578098
Abdominal mass 19.45 12.33 30 166003 3515 79574840
Superior vena cava syndrome 19.43 12.33 18 166015 1231 79577124
Dyskinesia 19.39 12.33 40 165993 44733 79533622
Amputation stump pain 19.32 12.33 6 166027 37 79578318
Metastases to muscle 19.30 12.33 11 166022 349 79578006
Ear pain 19.29 12.33 24 166009 32845 79545510
Human polyomavirus infection 19.29 12.33 17 166016 1089 79577266
Systolic dysfunction 19.28 12.33 31 166002 3764 79574591
Platelet disorder 19.27 12.33 27 166006 2902 79575453
Mental status changes 19.20 12.33 73 165960 66886 79511469
Lymphadenitis viral 19.17 12.33 7 166026 75 79578280
Splenic candidiasis 19.17 12.33 7 166026 75 79578280
Splenic lesion 19.14 12.33 13 166020 565 79577790
Hepatic fibrosis 19.13 12.33 45 165988 7235 79571120
Hormone receptor positive breast cancer 19.10 12.33 11 166022 356 79577999
Cardiac arrest 19.09 12.33 248 165785 171848 79406507
Transaminases 19.08 12.33 7 166026 76 79578279
Secretion discharge 19.05 12.33 4 166029 15018 79563337
Cyst 19.03 12.33 3 166030 13837 79564518
Anger 19.03 12.33 6 166027 17156 79561199
Primary mediastinal large B-cell lymphoma recurrent 19.00 12.33 7 166026 77 79578278
Guillain-Barre syndrome 18.93 12.33 51 165982 8914 79569441
Lipidosis 18.92 12.33 6 166027 40 79578315
Abdominal wound dehiscence 18.84 12.33 10 166023 275 79578080
Therapeutic response delayed 18.82 12.33 17 166016 1125 79577230
Fracture 18.80 12.33 11 166022 21790 79556565
PIK3CA-activated mutation 18.64 12.33 13 166020 590 79577765
Neuroborreliosis 18.63 12.33 8 166025 135 79578220
Hypertensive crisis 18.61 12.33 10 166023 20760 79557595
Musculoskeletal discomfort 18.59 12.33 9 166024 19826 79558529
Obliterative bronchiolitis 18.58 12.33 27 166006 3001 79575354
Asthenospermia 18.55 12.33 6 166027 43 79578312
Performance status decreased 18.53 12.33 40 165993 6073 79572282
Klebsiella sepsis 18.52 12.33 28 166005 3224 79575131
Diabetes mellitus 18.49 12.33 92 165941 78298 79500057
Spinal stenosis 18.46 12.33 5 166028 15786 79562569
Premature ageing 18.31 12.33 7 166026 86 79578269
Pharyngeal inflammation 18.30 12.33 16 166017 1014 79577341
Ocular hyperaemia 18.29 12.33 19 166014 28187 79550168
Hepatic lesion 18.27 12.33 43 165990 6916 79571439
Chromaturia 18.26 12.33 16 166017 25730 79552625
Vulvovaginitis 18.20 12.33 10 166023 295 79578060
Rash macular 18.15 12.33 20 166013 28879 79549476
Mydriasis 18.13 12.33 7 166026 17636 79560719
Bone density decreased 18.11 12.33 3 166030 13344 79565011
Head discomfort 18.11 12.33 4 166029 14498 79563857
Neurofibrosarcoma 18.11 12.33 9 166024 215 79578140
Inappropriate antidiuretic hormone secretion 18.10 12.33 105 165928 26208 79552147
Leukonychia 18.09 12.33 6 166027 47 79578308
Necrosis 18.07 12.33 52 165981 9441 79568914
Onycholysis 18.06 12.33 22 166011 2061 79576294
Pneumoperitoneum 18.04 12.33 27 166006 3081 79575274
Gastrointestinal protozoal infection 18.02 12.33 7 166026 90 79578265
Crying 18.01 12.33 13 166020 23030 79555325
Light chain analysis increased 18.00 12.33 20 166013 1698 79576657
Chest discomfort 17.98 12.33 192 165841 137852 79440503
Klebsiella test positive 17.95 12.33 20 166013 1703 79576652
Transplant rejection 17.94 12.33 9 166024 19428 79558927
Angina unstable 17.93 12.33 6 166027 16521 79561834
Paranasal sinus mucosal hypertrophy 17.88 12.33 7 166026 92 79578263
Spindle cell sarcoma 17.73 12.33 9 166024 225 79578130
Thrombocytopenia neonatal 17.68 12.33 5 166028 21 79578334
Gastric pneumatosis 17.68 12.33 5 166028 21 79578334
Graft versus host disease 17.66 12.33 70 165963 14956 79563399
Cachexia 17.62 12.33 57 165976 11026 79567329
Myelitis transverse 17.60 12.33 21 166012 1926 79576429
Periorbital cellulitis 17.58 12.33 15 166018 920 79577435
Jejunal stenosis 17.55 12.33 7 166026 97 79578258
Pulmonary vein stenosis 17.53 12.33 8 166025 157 79578198
Restless legs syndrome 17.53 12.33 10 166023 20082 79558273
Neutrophil count increased 17.50 12.33 113 165920 29283 79549072
Cardiac ventricular thrombosis 17.49 12.33 20 166013 1753 79576602
Pulmonary hypoplasia 17.46 12.33 6 166027 53 79578302
Ecchymosis 17.43 12.33 5 166028 15201 79563154
Cerebral toxoplasmosis 17.40 12.33 23 166010 2339 79576016
Enterocolitis 17.38 12.33 68 165965 14444 79563911
Plasma cell myeloma refractory 17.38 12.33 13 166020 659 79577696
Perineal infection 17.36 12.33 14 166019 793 79577562
Radiation skin injury 17.32 12.33 18 166015 1416 79576939
Adrenal insufficiency 17.26 12.33 110 165923 28377 79549978
Pseudocirrhosis 17.24 12.33 13 166020 667 79577688
Evans syndrome 17.23 12.33 11 166022 430 79577925
Heavy menstrual bleeding 17.23 12.33 4 166029 14007 79564348
Sphingomonas paucimobilis infection 17.17 12.33 7 166026 103 79578252
Cerebellar stroke 17.16 12.33 12 166021 547 79577808
Mitral valve incompetence 17.13 12.33 110 165923 28455 79549900
Hepatic amoebiasis 17.11 12.33 7 166026 104 79578251
Laryngitis 17.10 12.33 6 166027 16033 79562322
Peritonitis viral 17.07 12.33 6 166027 57 79578298
Secondary cerebellar degeneration 17.07 12.33 6 166027 57 79578298
Cancer fatigue 17.03 12.33 8 166025 168 79578187
Chronic hepatitis B 17.01 12.33 11 166022 440 79577915
Tracheal fistula 16.99 12.33 8 166025 169 79578186
Peripheral coldness 16.98 12.33 6 166027 15964 79562391
Acute pulmonary histoplasmosis 16.91 12.33 9 166024 249 79578106
Pneumonia salmonella 16.89 12.33 6 166027 59 79578296
Photophobia 16.81 12.33 11 166022 20517 79557838
Adenovirus infection 16.79 12.33 47 165986 8400 79569955
Enterocolitis infectious 16.76 12.33 25 166008 2844 79575511
Angioimmunoblastic T-cell lymphoma 16.72 12.33 11 166022 453 79577902
Underdose 16.69 12.33 27 166006 33124 79545231
Delusion 16.65 12.33 11 166022 20412 79557943
Pulmonary artery stenosis 16.64 12.33 7 166026 112 79578243
Facial paresis 16.57 12.33 36 165997 5490 79572865
Toxic encephalopathy 16.56 12.33 57 165976 11383 79566972
Febrile infection 16.55 12.33 27 166006 3319 79575036
Corynebacterium infection 16.53 12.33 17 166016 1321 79577034
Disseminated cytomegaloviral infection 16.49 12.33 11 166022 464 79577891
Herpes zoster 16.48 12.33 279 165754 92804 79485551
Bladder perforation 16.48 12.33 10 166023 357 79577998
Metastatic neoplasm 16.46 12.33 34 165999 5008 79573347
Streptococcal infection 16.45 12.33 48 165985 8782 79569573
Cutaneous T-cell lymphoma 16.44 12.33 24 166009 2679 79575676
Mantle cell lymphoma refractory 16.36 12.33 7 166026 117 79578238
Drug monitoring procedure incorrectly performed 16.32 12.33 11 166022 472 79577883
Hip arthroplasty 16.29 12.33 31 166002 35725 79542630
IIIrd nerve paralysis 16.29 12.33 16 166017 1177 79577178
Tenosynovitis 16.27 12.33 6 166027 15548 79562807
Chronic lymphocytic leukaemia refractory 16.25 12.33 7 166026 119 79578236
Ligament sprain 16.25 12.33 4 166029 13460 79564895
Acute leukaemia 16.24 12.33 19 166014 1707 79576648
Metastases to the mediastinum 16.22 12.33 12 166021 598 79577757
Urethral obstruction 16.22 12.33 9 166024 271 79578084
Pneumaturia 16.22 12.33 5 166028 30 79578325
Sarcoidosis 16.20 12.33 46 165987 8289 79570066
Molluscum contagiosum 16.20 12.33 11 166022 478 79577877
Acute erythroid leukaemia 16.19 12.33 9 166024 272 79578083
Squamous cell carcinoma of head and neck 16.16 12.33 9 166024 273 79578082
Staphylococcal infection 16.09 12.33 189 165844 58106 79520249
Gingivitis ulcerative 16.07 12.33 9 166024 276 79578079
Leukoplakia oral 16.07 12.33 9 166024 276 79578079
Tidal volume decreased 16.05 12.33 6 166027 69 79578286
Drug eruption 16.02 12.33 43 165990 43892 79534463
Gastrointestinal inflammation 16.01 12.33 43 165990 7501 79570854
Lymph node fibrosis 16.01 12.33 4 166029 9 79578346
Human herpesvirus 8 infection 15.99 12.33 16 166017 1204 79577151
Bone marrow necrosis 15.98 12.33 9 166024 279 79578076
Sudden death 15.96 12.33 14 166019 22497 79555858
Blood creatinine increased 15.92 12.33 227 165806 154830 79423525
Aspergilloma 15.91 12.33 12 166021 616 79577739
Bicytopenia 15.84 12.33 32 166001 4638 79573717
Minimal residual disease 15.84 12.33 11 166022 496 79577859
Mucoepidermoid carcinoma 15.82 12.33 6 166027 72 79578283
Feeling cold 15.82 12.33 22 166011 28707 79549648
Salivary gland neoplasm 15.79 12.33 7 166026 128 79578227
Papillary thyroid cancer 15.78 12.33 23 166010 2563 79575792
Product storage error 15.77 12.33 7 166026 16219 79562136
Angina pectoris 15.75 12.33 55 165978 51677 79526678
Intensive care 15.75 12.33 15 166018 1062 79577293
Eye irritation 15.73 12.33 12 166021 20669 79557686
Post-acute COVID-19 syndrome 15.68 12.33 11 166022 504 79577851
Incorrect product administration duration 15.67 12.33 3 166030 12019 79566336
Muscle spasticity 15.66 12.33 13 166020 21462 79556893
Large intestine perforation 15.65 12.33 66 165967 14501 79563854
Extramedullary haemopoiesis 15.64 12.33 7 166026 131 79578224
Wound evisceration 15.64 12.33 7 166026 131 79578224
Hypercalcaemia 15.64 12.33 135 165898 38295 79540060
Hypersensitivity pneumonitis 15.63 12.33 28 166005 3711 79574644
Hyperleukocytosis 15.62 12.33 23 166010 2587 79575768
Mucosal infection 15.61 12.33 11 166022 508 79577847
Skin haemorrhage 15.59 12.33 3 166030 11978 79566377
Spinal column injury 15.57 12.33 21 166012 2177 79576178
Lymphoedema 15.55 12.33 59 165974 12354 79566001
Dystonia 15.54 12.33 13 166020 21386 79556969
Hypofibrinogenaemia 15.53 12.33 20 166013 1982 79576373
Omental infarction 15.53 12.33 3 166030 0 79578355
Administration site injury 15.53 12.33 3 166030 0 79578355
Anaplastic large cell lymphoma T- and null-cell types recurrent 15.53 12.33 3 166030 0 79578355
Wrist fracture 15.48 12.33 3 166030 11918 79566437
Retroperitoneal lymphadenopathy 15.48 12.33 15 166018 1085 79577270
Right ventricular dysfunction 15.45 12.33 23 166010 2612 79575743
Blood urea increased 15.45 12.33 51 165982 48739 79529616
Paraesthesia oral 15.42 12.33 12 166021 20459 79557896
Mood altered 15.40 12.33 9 166024 17838 79560517
Empyema 15.35 12.33 30 166003 4246 79574109
Bacterial translocation 15.35 12.33 12 166021 650 79577705
Food protein-induced enterocolitis syndrome 15.32 12.33 5 166028 37 79578318
Metastases to abdominal cavity 15.32 12.33 12 166021 652 79577703
Paraplegia 15.25 12.33 33 166000 5020 79573335
Peripheral venous disease 15.25 12.33 7 166026 15902 79562453
Invasive breast carcinoma 15.21 12.33 11 166022 529 79577826
Device dislocation 15.20 12.33 19 166014 25951 79552404
Disorientation 15.19 12.33 73 165960 62703 79515652
Infusion site joint movement impairment 15.19 12.33 4 166029 12 79578343
Metapneumovirus bronchiolitis 15.19 12.33 4 166029 12 79578343
Suspected product quality issue 15.18 12.33 9 166024 308 79578047
Lethargy 15.11 12.33 103 165930 81189 79497166
Oligospermia 15.09 12.33 5 166028 39 79578316
Torulopsis infection 15.09 12.33 5 166028 39 79578316
Pleural disorder 15.09 12.33 14 166019 959 79577396
Right ventricular failure 15.04 12.33 16 166017 23481 79554874
Dysarthria 15.02 12.33 81 165952 67541 79510814
Blood triglycerides increased 15.02 12.33 13 166020 21027 79557328
Toxic neuropathy 15.00 12.33 14 166019 966 79577389
Lewis-Sumner syndrome 14.98 12.33 5 166028 40 79578315
Malnutrition 14.97 12.33 89 165944 22413 79555942
Fasciitis 14.95 12.33 13 166020 818 79577537
Opsoclonus myoclonus 14.94 12.33 8 166025 224 79578131
Blastic plasmacytoid dendritic cell neoplasia 14.92 12.33 6 166027 85 79578270
Cancer in remission 14.87 12.33 5 166028 41 79578314
Aortitis 14.86 12.33 17 166016 1490 79576865
Enteritis 14.84 12.33 65 165968 14518 79563837
Parkinsonism 14.83 12.33 8 166025 16576 79561779
Osteopenia 14.83 12.33 10 166023 18354 79560001
Anaplastic large-cell lymphoma 14.81 12.33 8 166025 228 79578127
Parainfluenzae virus infection 14.80 12.33 35 165998 5647 79572708
Rib fracture 14.79 12.33 22 166011 27925 79550430
Hepatic infection fungal 14.75 12.33 8 166025 230 79578125
Soft tissue infection 14.72 12.33 28 166005 3884 79574471
Troponin increased 14.68 12.33 79 165954 19176 79559179
Device issue 14.68 12.33 21 166012 27087 79551268
Morphoea 14.64 12.33 10 166023 439 79577916
Adult T-cell lymphoma/leukaemia 14.59 12.33 9 166024 331 79578024
Coordination abnormal 14.56 12.33 9 166024 17303 79561052
Pneumothorax 14.55 12.33 105 165928 28218 79550137
Ichthyosis 14.53 12.33 7 166026 156 79578199
Blood disorder 14.49 12.33 44 165989 8229 79570126
Hypothalamo-pituitary disorder 14.45 12.33 15 166018 1179 79577176
Post procedural complication 14.41 12.33 17 166016 23812 79554543
Central nervous system infection 14.38 12.33 16 166017 1361 79576994
Granulomatous pneumonitis 14.37 12.33 6 166027 94 79578261
Hallucination, visual 14.37 12.33 29 166004 32700 79545655
T-cell prolymphocytic leukaemia 14.37 12.33 5 166028 46 79578309
Mediastinal mass 14.33 12.33 11 166022 580 79577775
Hypogonadism 14.32 12.33 18 166015 1742 79576613
Noctiphobia 14.30 12.33 4 166029 16 79578339
Beta 2 microglobulin decreased 14.30 12.33 4 166029 16 79578339
Hydronephrosis 14.26 12.33 73 165960 17381 79560974
BRCA2 gene mutation 14.26 12.33 6 166027 96 79578259
Metastatic lymphoma 14.26 12.33 9 166024 345 79578010
Skin irritation 14.24 12.33 3 166030 11237 79567118
Intervertebral disc protrusion 14.13 12.33 17 166016 23604 79554751
Synovial sarcoma metastatic 14.11 12.33 4 166029 17 79578338
Metastases to vagina 14.11 12.33 4 166029 17 79578338
KMT2A gene mutation 14.11 12.33 4 166029 17 79578338
Hepatomegaly 14.10 12.33 77 165956 18797 79559558
Hepatitis viral 14.09 12.33 14 166019 1044 79577311
Tracheo-oesophageal fistula 14.08 12.33 11 166022 595 79577760
Akathisia 14.07 12.33 5 166028 13254 79565101
Melaena 14.05 12.33 72 165961 60818 79517537
Ankylosing spondylitis 14.02 12.33 4 166029 12201 79566154
Blood culture positive 13.99 12.33 44 165989 8385 79569970
Spinal cord ischaemia 13.98 12.33 7 166026 170 79578185
Joint dislocation 13.98 12.33 9 166024 16930 79561425
Pulmonary thrombosis 13.96 12.33 4 166029 12167 79566188
Lung adenocarcinoma 13.94 12.33 42 165991 7822 79570533
Pneumonia aspiration 13.91 12.33 82 165951 66885 79511470
Splenic necrosis 13.90 12.33 7 166026 172 79578183
Cryptococcal fungaemia 13.90 12.33 7 166026 172 79578183
Upper respiratory tract infection 13.90 12.33 122 165911 91046 79487309
Oropharyngeal pain 13.88 12.33 153 165880 109200 79469155
Dermatitis contact 13.87 12.33 3 166030 11030 79567325
Infusion related reaction 13.85 12.33 369 165664 229868 79348487
Failure to thrive 13.78 12.33 55 165978 11789 79566566
Proctalgia 13.76 12.33 49 165984 9952 79568403
Fusarium infection 13.74 12.33 18 166015 1814 79576541
Full blood count abnormal 13.74 12.33 41 165992 40433 79537922
Cough 13.69 12.33 624 165409 366165 79212190
Acanthosis 13.68 12.33 10 166023 489 79577866
Eructation 13.64 12.33 3 166030 10906 79567449
Malignant neoplasm of orbit 13.58 12.33 4 166029 20 79578335
Pulmonary cavitation 13.57 12.33 17 166016 1639 79576716
Gas gangrene 13.56 12.33 8 166025 271 79578084
Oligohydramnios 13.56 12.33 25 166008 3387 79574968
Respiratory tract infection 13.50 12.33 158 165875 48531 79529824
Nervous system disorder 13.48 12.33 99 165934 26757 79551598
Autoimmune disorder 13.47 12.33 9 166024 16603 79561752
Cerebellar syndrome 13.46 12.33 33 166000 5447 79572908
Increased liver stiffness 13.46 12.33 3 166030 3 79578352
Scedosporium infection 13.45 12.33 16 166017 1462 79576893
Diaphragm muscle weakness 13.41 12.33 7 166026 186 79578169
Hyperlipidaemia 13.37 12.33 21 166012 26072 79552283
Pneumonia respiratory syncytial viral 13.30 12.33 18 166015 1872 79576483
Pharyngitis streptococcal 13.29 12.33 3 166030 10711 79567644
Mediastinal fibrosis 13.27 12.33 4 166029 22 79578333
Genital infection 13.24 12.33 7 166026 191 79578164
Adenoviral haemorrhagic cystitis 13.23 12.33 10 166023 515 79577840
Triple negative breast cancer 13.23 12.33 6 166027 116 79578239
Deafness 13.23 12.33 82 165951 20955 79557400
Anaesthesia 13.20 12.33 10 166023 517 79577838
Rectal fissure 13.17 12.33 13 166020 962 79577393
Systemic inflammatory response syndrome 13.15 12.33 53 165980 11412 79566943
Cryptococcosis 13.14 12.33 25 166008 3468 79574887
Scrotal abscess 13.11 12.33 10 166023 522 79577833
Platelet transfusion 13.10 12.33 20 166013 2322 79576033
Hypoglossal nerve paresis 13.09 12.33 6 166027 119 79578236
Granulomatous liver disease 13.09 12.33 15 166018 1318 79577037
Paresis 13.05 12.33 28 166005 4233 79574122
Blood pressure diastolic increased 13.03 12.33 7 166026 14535 79563820
Lymphoproliferative disorder 12.94 12.33 33 166000 5582 79572773
Skin discolouration 12.92 12.33 43 165990 40991 79537364
Gastrointestinal haemorrhage 12.89 12.33 223 165810 147496 79430859
Hip deformity 12.88 12.33 7 166026 202 79578153
Hepatic cirrhosis 12.85 12.33 34 165999 34872 79543483
Stomatitis necrotising 12.85 12.33 7 166026 203 79578152
Lymph node pain 12.84 12.33 16 166017 1534 79576821
Listeria encephalitis 12.81 12.33 8 166025 301 79578054
Duodenal perforation 12.80 12.33 19 166014 2153 79576202
Extravasation blood 12.78 12.33 9 166024 415 79577940
Breast cancer female 12.72 12.33 4 166029 11457 79566898
Platelet count abnormal 12.72 12.33 30 166003 4832 79573523
Deafness bilateral 12.71 12.33 19 166014 2166 79576189
Thirst 12.70 12.33 12 166021 18607 79559748
Pulmonary sarcoidosis 12.69 12.33 15 166018 1362 79576993
Device use error 12.66 12.33 38 165995 7063 79571292
T-cell lymphoma recurrent 12.62 12.33 5 166028 68 79578287
Hyperviscosity syndrome 12.61 12.33 9 166024 424 79577931
Mediastinitis 12.57 12.33 12 166021 852 79577503
Infusion site necrosis 12.55 12.33 5 166028 69 79578286
Femur fracture 12.52 12.33 40 165993 38612 79539743
B-cell aplasia 12.52 12.33 7 166026 214 79578141
C-reactive protein increased 12.51 12.33 191 165842 128836 79449519
Systemic mycosis 12.49 12.33 21 166012 2645 79575710
Tuberculosis liver 12.49 12.33 5 166028 70 79578285
Spinal disorder 12.47 12.33 3 166030 10257 79568098
Necrotising colitis 12.47 12.33 13 166020 1027 79577328
Staphyloma 12.45 12.33 4 166029 28 79578327
Incontinence 12.43 12.33 7 166026 14157 79564198
Acute hepatitis C 12.40 12.33 7 166026 218 79578137
Metastases to pancreas 12.35 12.33 10 166023 570 79577785
Obesity 12.35 12.33 35 165998 35090 79543265

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01DB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
FDA CS M0028312 Anthracyclines
FDA MoA N0000000176 Topoisomerase Inhibitors
FDA EPC N0000175414 Anthracycline Topoisomerase Inhibitor
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute myeloid leukemia, disease indication 91861009
Kaposi's sarcoma indication 109385007
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Small cell carcinoma of lung indication 254632001 DOID:5409
Carcinoma of breast indication 254838004 DOID:3459
Nephroblastoma indication 302849000 DOID:2154
Osteosarcoma of bone indication 307576001 DOID:3376
Follicular non-Hodgkin's lymphoma indication 308121000
Malignant tumor of lung indication 363358000
Advanced ovarian cancer indication 363443007 DOID:2394
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Kaposi's sarcoma associated with AIDS indication 420524008
Neuroblastoma indication 432328008 DOID:769
Carcinoma of female breast indication 447782002
Soft or Connective Tissue Sarcoma indication
Metastatic Breast Carcinoma indication
Invasive Bladder Malignancy indication
Metastatic Gastric Cancer indication
Carcinoid syndrome off-label use 35868009
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Malignant neoplasm of liver off-label use 93870000 DOID:3571
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Primary cutaneous T-cell lymphoma off-label use 400122007
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Pancreatic Neuroendocrine Tumor off-label use 717919005
Mycosis contraindication 3218000 DOID:1564
Bundle branch block contraindication 6374002
Hyperbilirubinemia contraindication 14783006 DOID:2741
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Conduction disorder of the heart contraindication 44808001
Myocarditis contraindication 50920009 DOID:820
Heart disease contraindication 56265001 DOID:114
Hepatic failure contraindication 59927004
Heart failure contraindication 84114007 DOID:6000
Leukopenia contraindication 84828003 DOID:615
Cardiomyopathy contraindication 85898001 DOID:0050700
Bacterial infectious disease contraindication 87628006
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Atrioventricular block contraindication 233917008 DOID:0050820
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Asymptomatic left ventricular systolic dysfunction contraindication 698592004
Protozoal Infection contraindication
Severe Cardiac Disease contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.85 acidic
pKa2 9.21 acidic
pKa3 9.92 acidic
pKa4 11.11 acidic
pKa5 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 6 CHEMBL CHEMBL
Multidrug resistance protein 1 Transporter IC50 4.01 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.43 DRUG MATRIX
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Caspase-1 Enzyme IC50 4.91 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.29 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.61 DRUG MATRIX
72 kDa type IV collagenase Enzyme IC50 5.96 CHEMBL
DNA topoisomerase 1 Enzyme IC50 4.70 CHEMBL
Telomerase reverse transcriptase Enzyme IC50 4.14 CHEMBL
DNA topoisomerase 2-beta Enzyme IC50 5.46 CHEMBL
Aurora kinase A Kinase IC50 7.40 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Unclassified Ki 5.46 CHEMBL
Ribonuclease pancreatic Enzyme IC50 4.60 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 4.87 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 4.81 DRUG MATRIX
Integrase Enzyme IC50 6.05 CHEMBL
Reverse transcriptase/RNaseH Enzyme IC50 4.28 CHEMBL
Reverse transcriptase Enzyme IC50 4.28 CHEMBL
Type-2 restriction enzyme HindIII Unclassified IC50 4.02 CHEMBL
Type-2 restriction enzyme ScaI Unclassified IC50 4.60 CHEMBL
ORF 73 Unclassified AC50 5.84 CHEMBL
UDP-galactopyranose mutase Enzyme AC50 4.49 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 5.68 DRUG MATRIX
DNA Enzyme IC50 5.52 CHEMBL

External reference:

IDSource
4019737 VUID
N0000147829 NUI
D01275 KEGG_DRUG
25316-40-9 SECONDARY_CAS_RN
4018106 VANDF
4019737 VANDF
C0013089 UMLSCUI
CHEBI:28748 CHEBI
DM2 PDB_CHEM_ID
CHEMBL53463 ChEMBL_ID
CHEMBL359744 ChEMBL_ID
D004317 MESH_DESCRIPTOR_UI
DB00997 DRUGBANK_ID
7069 IUPHAR_LIGAND_ID
C506643 MESH_SUPPLEMENTAL_RECORD_UI
3005 INN_ID
80168379AG UNII
31703 PUBCHEM_CID
142433 RXNORM
3368 MMSL
4639 MMSL
47543 MMSL
47549 MMSL
d00218 MMSL
d04004 MMSL
002659 NDDF
004818 NDDF
372817009 SNOMEDCT_US
428681007 SNOMEDCT_US
68444001 SNOMEDCT_US
90875009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3030 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3030 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3032 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3032 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3033 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3033 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3034 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3034 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4004 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4004 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4015 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4015 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4026 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4026 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4037 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4037 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9084 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9085 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9086 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9087 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9088 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9089 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9090 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9091 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9092 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9092 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9093 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9093 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections