doxofylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 959 69975-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxofylline
  • ansimar
  • dioxyfilline
  • doxophylline
  • Molecular weight: 266.26
  • Formula: C11H14N4O4
  • CLOGP: -0.42
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 0
  • TPSA: 76.90
  • ALOGS: -1.26
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.80 g O
0.80 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.03 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.83 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.66 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia 63.56 41.51 44 381 362583 34593923

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia 84.46 45.09 54 517 660192 79083625

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DA11 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000996 Antitussive Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:51177 anti-tussive

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03898 KEGG_DRUG
C0058721 UMLSCUI
CHEBI:94714 CHEBI
7UH PDB_CHEM_ID
CHEMBL1527608 ChEMBL_ID
DB09273 DRUGBANK_ID
C029797 MESH_SUPPLEMENTAL_RECORD_UI
50942 PUBCHEM_CID
5156 INN_ID
MPM23GMO7Z UNII
010905 NDDF
1173992002 SNOMEDCT_US
1177091008 SNOMEDCT_US

Pharmaceutical products:

None