Stem definition | Drug id | CAS RN |
---|---|---|
N-methylated xanthine derivatives | 959 | 69975-86-6 |
Molecule | Description |
---|---|
Synonyms:
|
|
Dose | Unit | Route |
---|---|---|
0.80 | g | O |
0.80 | g | P |
Property | Value | Reference |
---|---|---|
Vd (Volume of distribution) | 1.03 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 6.83 mL/min/kg | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.66 hours | Lombardo F, Berellini G, Obach RS |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pneumonia | 63.56 | 41.51 | 44 | 381 | 362583 | 34593923 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pneumonia | 84.46 | 45.09 | 54 | 517 | 660192 | 79083625 |
None
Source | Code | Description |
---|---|---|
ATC | R03DA11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Xanthines |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D000996 | Antitussive Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D019141 | Respiratory System Agents |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
CHEBI has role | CHEBI:51177 | anti-tussive |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 0.36 | Basic |
None
None
None
ID | Source |
---|---|
D03898 | KEGG_DRUG |
C0058721 | UMLSCUI |
CHEBI:94714 | CHEBI |
7UH | PDB_CHEM_ID |
CHEMBL1527608 | ChEMBL_ID |
DB09273 | DRUGBANK_ID |
C029797 | MESH_SUPPLEMENTAL_RECORD_UI |
50942 | PUBCHEM_CID |
5156 | INN_ID |
MPM23GMO7Z | UNII |
010905 | NDDF |
1173992002 | SNOMEDCT_US |
1177091008 | SNOMEDCT_US |
None