doxofylline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 959 69975-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxofylline
  • ansimar
  • dioxyfilline
  • doxophylline
  • Molecular weight: 266.26
  • Formula: C11H14N4O4
  • CLOGP: -0.42
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 0
  • TPSA: 76.90
  • ALOGS: -1.26
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.80 g O
0.80 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.03 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.83 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.66 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DA11 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:49167 anti-asthmatic drug
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000996 Antitussive Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03898 KEGG_DRUG
010905 NDDF
CHEBI:94714 CHEBI
MPM23GMO7Z UNII
5156 INN_ID
DB09273 DRUGBANK_ID
50942 PUBCHEM_CID
CHEMBL1527608 ChEMBL_ID
C029797 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None