Stem definition | Drug id | CAS RN |
---|---|---|
946 | 120014-06-4 |
Dose | Unit | Route |
---|---|---|
7.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10.60 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.38 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 25, 1996 | FDA | EISAI INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Bradycardia | 548.25 | 12.94 | 410 | 32886 | 70646 | 53245124 |
Fall | 422.60 | 12.94 | 780 | 32516 | 357660 | 52958110 |
Dementia | 312.15 | 12.94 | 169 | 33127 | 16581 | 53299189 |
Syncope | 289.77 | 12.94 | 353 | 32943 | 111640 | 53204130 |
Electrocardiogram QT prolonged | 281.91 | 12.94 | 253 | 33043 | 56150 | 53259620 |
Confusional state | 237.13 | 12.94 | 430 | 32866 | 193791 | 53121979 |
Sinus bradycardia | 232.87 | 12.94 | 133 | 33163 | 14468 | 53301302 |
Hallucination | 207.07 | 12.94 | 209 | 33087 | 53629 | 53262141 |
Drug interaction | 203.85 | 12.94 | 433 | 32863 | 218896 | 53096874 |
Torsade de pointes | 187.61 | 12.94 | 111 | 33185 | 12894 | 53302876 |
Agitation | 176.70 | 12.94 | 200 | 33096 | 58426 | 53257344 |
Cognitive disorder | 165.19 | 12.94 | 170 | 33126 | 44608 | 53271162 |
Dementia Alzheimer's type | 160.97 | 12.94 | 50 | 33246 | 1147 | 53314623 |
Delusion | 156.42 | 12.94 | 96 | 33200 | 11913 | 53303857 |
Aggression | 156.00 | 12.94 | 124 | 33172 | 23279 | 53292491 |
Abnormal behaviour | 143.92 | 12.94 | 115 | 33181 | 21751 | 53294019 |
Delirium | 139.80 | 12.94 | 150 | 33146 | 41279 | 53274491 |
Rheumatoid arthritis | 133.41 | 12.94 | 19 | 33277 | 314512 | 53001258 |
Neuroleptic malignant syndrome | 131.28 | 12.94 | 86 | 33210 | 11947 | 53303823 |
Parkinsonism | 130.18 | 12.94 | 77 | 33219 | 8936 | 53306834 |
Drug ineffective | 129.07 | 12.94 | 195 | 33101 | 817050 | 52498720 |
Pleurothotonus | 118.29 | 12.94 | 41 | 33255 | 1338 | 53314432 |
Seizure | 107.92 | 12.94 | 245 | 33051 | 129264 | 53186506 |
Arthralgia | 105.41 | 12.94 | 73 | 33223 | 439710 | 52876060 |
Hallucination, visual | 103.02 | 12.94 | 89 | 33207 | 18743 | 53297027 |
Somnolence | 97.67 | 12.94 | 277 | 33019 | 167457 | 53148313 |
Cholinergic syndrome | 90.74 | 12.94 | 25 | 33271 | 370 | 53315400 |
Sinus node dysfunction | 89.65 | 12.94 | 47 | 33249 | 4314 | 53311456 |
Pain | 88.24 | 12.94 | 145 | 33151 | 588253 | 52727517 |
Tremor | 87.65 | 12.94 | 222 | 33074 | 125514 | 53190256 |
Loss of consciousness | 86.31 | 12.94 | 208 | 33088 | 114004 | 53201766 |
Extrapyramidal disorder | 85.40 | 12.94 | 67 | 33229 | 12335 | 53303435 |
Myoclonus | 85.21 | 12.94 | 74 | 33222 | 15690 | 53300080 |
Alopecia | 82.94 | 12.94 | 22 | 33274 | 234561 | 53081209 |
Altered state of consciousness | 80.39 | 12.94 | 88 | 33208 | 24748 | 53291022 |
Electrocardiogram PR prolongation | 80.00 | 12.94 | 26 | 33270 | 693 | 53315077 |
Femoral neck fracture | 79.66 | 12.94 | 55 | 33241 | 8328 | 53307442 |
Muscle rigidity | 77.75 | 12.94 | 60 | 33236 | 10781 | 53304989 |
Hypersensitivity | 75.92 | 12.94 | 19 | 33277 | 210646 | 53105124 |
Decreased appetite | 75.18 | 12.94 | 299 | 32997 | 214675 | 53101095 |
Depressed level of consciousness | 74.58 | 12.94 | 127 | 33169 | 54301 | 53261469 |
Atrioventricular block first degree | 74.45 | 12.94 | 48 | 33248 | 6487 | 53309283 |
Joint swelling | 74.01 | 12.94 | 27 | 33269 | 234611 | 53081159 |
Dehydration | 72.04 | 12.94 | 250 | 33046 | 168160 | 53147610 |
Hypothermia | 72.01 | 12.94 | 62 | 33234 | 12994 | 53302776 |
Torticollis | 71.21 | 12.94 | 31 | 33265 | 1879 | 53313891 |
Rash | 70.54 | 12.94 | 106 | 33190 | 446085 | 52869685 |
Mental status changes | 68.88 | 12.94 | 103 | 33193 | 39468 | 53276302 |
Immobile | 66.11 | 12.94 | 41 | 33255 | 5179 | 53310591 |
Urinary retention | 65.89 | 12.94 | 85 | 33211 | 28381 | 53287389 |
Mania | 64.89 | 12.94 | 56 | 33240 | 11773 | 53303997 |
Treatment failure | 64.24 | 12.94 | 4 | 33292 | 128399 | 53187371 |
Disorientation | 63.64 | 12.94 | 99 | 33197 | 39260 | 53276510 |
Urinary incontinence | 63.60 | 12.94 | 87 | 33209 | 30734 | 53285036 |
Hypokalaemia | 62.68 | 12.94 | 166 | 33130 | 96351 | 53219419 |
Infusion related reaction | 62.46 | 12.94 | 11 | 33285 | 155946 | 53159824 |
Systemic lupus erythematosus | 59.60 | 12.94 | 5 | 33291 | 125409 | 53190361 |
Nightmare | 59.37 | 12.94 | 64 | 33232 | 17687 | 53298083 |
Hypophagia | 58.61 | 12.94 | 84 | 33212 | 30978 | 53284792 |
Sinusitis | 57.34 | 12.94 | 17 | 33279 | 168547 | 53147223 |
Arthropathy | 56.60 | 12.94 | 10 | 33286 | 141443 | 53174327 |
Lethargy | 55.45 | 12.94 | 111 | 33185 | 53649 | 53262121 |
Urinary tract infection | 54.42 | 12.94 | 294 | 33002 | 239609 | 53076161 |
Dyskinesia | 52.76 | 12.94 | 81 | 33215 | 31752 | 53284018 |
Swelling | 52.29 | 12.94 | 27 | 33269 | 191078 | 53124692 |
Pruritus | 52.23 | 12.94 | 64 | 33232 | 293768 | 53022002 |
Sudden death | 49.21 | 12.94 | 45 | 33251 | 10203 | 53305567 |
Drug hypersensitivity | 49.03 | 12.94 | 56 | 33240 | 265186 | 53050584 |
Wandering pacemaker | 48.49 | 12.94 | 8 | 33288 | 3 | 53315767 |
Unresponsive to stimuli | 48.44 | 12.94 | 80 | 33216 | 33346 | 53282424 |
Gastrointestinal haemorrhage | 46.02 | 12.94 | 132 | 33164 | 80198 | 53235572 |
Restlessness | 45.89 | 12.94 | 71 | 33225 | 28016 | 53287754 |
Pain in extremity | 45.66 | 12.94 | 67 | 33229 | 284983 | 53030787 |
Cerebral atrophy | 45.60 | 12.94 | 32 | 33264 | 4972 | 53310798 |
Reduced facial expression | 45.11 | 12.94 | 22 | 33274 | 1732 | 53314038 |
Glossodynia | 45.01 | 12.94 | 5 | 33291 | 100286 | 53215484 |
Pemphigus | 44.69 | 12.94 | 6 | 33290 | 104025 | 53211745 |
Psychomotor hyperactivity | 43.99 | 12.94 | 42 | 33254 | 10054 | 53305716 |
Hypocapnia | 43.33 | 12.94 | 14 | 33282 | 366 | 53315404 |
Circulatory collapse | 42.23 | 12.94 | 61 | 33235 | 22653 | 53293117 |
Atrioventricular block complete | 42.06 | 12.94 | 37 | 33259 | 7978 | 53307792 |
Generalised tonic-clonic seizure | 41.90 | 12.94 | 69 | 33227 | 28689 | 53287081 |
Tardive dyskinesia | 41.84 | 12.94 | 37 | 33259 | 8033 | 53307737 |
Drug intolerance | 41.76 | 12.94 | 40 | 33256 | 205453 | 53110317 |
Encephalopathy | 41.60 | 12.94 | 79 | 33217 | 36729 | 53279041 |
Anal incontinence | 41.24 | 12.94 | 45 | 33251 | 12602 | 53303168 |
Apathy | 40.89 | 12.94 | 37 | 33259 | 8275 | 53307495 |
Medication error | 39.81 | 12.94 | 77 | 33219 | 36288 | 53279482 |
Cough | 39.57 | 12.94 | 62 | 33234 | 256831 | 53058939 |
Hypersexuality | 39.24 | 12.94 | 14 | 33282 | 498 | 53315272 |
Memory impairment | 38.98 | 12.94 | 129 | 33167 | 84628 | 53231142 |
Sexually inappropriate behaviour | 38.77 | 12.94 | 10 | 33286 | 113 | 53315657 |
Hip fracture | 38.77 | 12.94 | 66 | 33230 | 28191 | 53287579 |
Febrile neutropenia | 38.68 | 12.94 | 9 | 33287 | 104927 | 53210843 |
Headache | 37.59 | 12.94 | 190 | 33106 | 536631 | 52779139 |
Lower respiratory tract infection | 37.34 | 12.94 | 6 | 33290 | 90975 | 53224795 |
Off label use | 37.26 | 12.94 | 160 | 33136 | 472052 | 52843718 |
Neuropsychiatric symptoms | 36.39 | 12.94 | 14 | 33282 | 617 | 53315153 |
Pneumonia aspiration | 35.57 | 12.94 | 71 | 33225 | 34230 | 53281540 |
Gait disturbance | 35.52 | 12.94 | 194 | 33102 | 158648 | 53157122 |
Long QT syndrome | 34.59 | 12.94 | 23 | 33273 | 3273 | 53312497 |
Miosis | 34.12 | 12.94 | 31 | 33265 | 6971 | 53308799 |
Epilepsy | 33.80 | 12.94 | 59 | 33237 | 25708 | 53290062 |
Psoriasis | 33.04 | 12.94 | 7 | 33289 | 87082 | 53228688 |
Dementia with Lewy bodies | 32.97 | 12.94 | 11 | 33285 | 319 | 53315451 |
Therapeutic product effect decreased | 32.54 | 12.94 | 19 | 33277 | 125636 | 53190134 |
Listless | 32.03 | 12.94 | 20 | 33276 | 2556 | 53313214 |
Weight increased | 31.84 | 12.94 | 49 | 33247 | 204518 | 53111252 |
Atrioventricular block | 31.67 | 12.94 | 30 | 33266 | 7110 | 53308660 |
Atrial tachycardia | 31.64 | 12.94 | 19 | 33277 | 2265 | 53313505 |
Dyspnoea | 31.30 | 12.94 | 226 | 33070 | 586006 | 52729764 |
Infection | 31.10 | 12.94 | 37 | 33259 | 172168 | 53143602 |
Rhabdomyolysis | 31.02 | 12.94 | 78 | 33218 | 43845 | 53271925 |
Lack of spontaneous speech | 30.97 | 12.94 | 9 | 33287 | 163 | 53315607 |
Fatigue | 30.73 | 12.94 | 300 | 32996 | 730206 | 52585564 |
Dizziness | 30.68 | 12.94 | 361 | 32935 | 371898 | 52943872 |
Hyponatraemia | 30.14 | 12.94 | 141 | 33155 | 108466 | 53207304 |
Parkinson's disease | 30.05 | 12.94 | 16 | 33280 | 1515 | 53314255 |
Sinus arrest | 29.93 | 12.94 | 17 | 33279 | 1827 | 53313943 |
Incontinence | 29.56 | 12.94 | 35 | 33261 | 10708 | 53305062 |
Pericarditis | 29.43 | 12.94 | 3 | 33293 | 64403 | 53251367 |
Product administration interrupted | 29.43 | 12.94 | 13 | 33283 | 816 | 53314954 |
Paratonia | 29.05 | 12.94 | 6 | 33290 | 22 | 53315748 |
Fluid intake reduced | 28.88 | 12.94 | 21 | 33275 | 3448 | 53312322 |
Hypotension | 28.80 | 12.94 | 263 | 33033 | 253813 | 53061957 |
Fracture | 28.66 | 12.94 | 45 | 33251 | 17974 | 53297796 |
Stomatitis | 28.14 | 12.94 | 13 | 33283 | 98145 | 53217625 |
Accidental overdose | 27.94 | 12.94 | 49 | 33247 | 21430 | 53294340 |
Wrong patient received product | 27.67 | 12.94 | 17 | 33279 | 2111 | 53313659 |
Dysarthria | 27.56 | 12.94 | 71 | 33225 | 40497 | 53275273 |
Atrial fibrillation | 27.43 | 12.94 | 140 | 33156 | 111512 | 53204258 |
Delusional disorder, persecutory type | 27.22 | 12.94 | 8 | 33288 | 151 | 53315619 |
Nasopharyngitis | 27.20 | 12.94 | 49 | 33247 | 192246 | 53123524 |
Hypernatraemia | 26.56 | 12.94 | 27 | 33269 | 6970 | 53308800 |
Abdominal discomfort | 26.46 | 12.94 | 62 | 33234 | 221000 | 53094770 |
Posture abnormal | 26.17 | 12.94 | 17 | 33279 | 2326 | 53313444 |
Speech disorder | 26.03 | 12.94 | 68 | 33228 | 39113 | 53276657 |
Overconfidence | 25.52 | 12.94 | 4 | 33292 | 0 | 53315770 |
Cerebrovascular accident | 25.23 | 12.94 | 131 | 33165 | 105043 | 53210727 |
Therapeutic product effect incomplete | 25.03 | 12.94 | 13 | 33283 | 91771 | 53223999 |
Hyperhidrosis | 24.93 | 12.94 | 123 | 33173 | 96670 | 53219100 |
Oropharyngeal pain | 24.51 | 12.94 | 10 | 33286 | 81258 | 53234512 |
Grandiosity | 24.28 | 12.94 | 8 | 33288 | 223 | 53315547 |
Pelvic fracture | 24.15 | 12.94 | 34 | 33262 | 12330 | 53303440 |
Suspiciousness | 24.10 | 12.94 | 9 | 33287 | 365 | 53315405 |
Cerebral haemorrhage | 24.10 | 12.94 | 56 | 33240 | 29940 | 53285830 |
Product use issue | 23.11 | 12.94 | 32 | 33264 | 139552 | 53176218 |
Colitis microscopic | 22.71 | 12.94 | 25 | 33271 | 7069 | 53308701 |
Anger | 22.63 | 12.94 | 33 | 33263 | 12357 | 53303413 |
Chorea | 22.58 | 12.94 | 13 | 33283 | 1434 | 53314336 |
Ventricular tachycardia | 22.43 | 12.94 | 40 | 33256 | 17722 | 53298048 |
Social avoidant behaviour | 22.34 | 12.94 | 17 | 33279 | 2991 | 53312779 |
Bedridden | 22.17 | 12.94 | 29 | 33267 | 9808 | 53305962 |
Drug level increased | 22.05 | 12.94 | 43 | 33253 | 20378 | 53295392 |
Chest discomfort | 21.93 | 12.94 | 18 | 33278 | 99677 | 53216093 |
Hepatic enzyme increased | 21.84 | 12.94 | 28 | 33268 | 126167 | 53189603 |
Food refusal | 21.67 | 12.94 | 8 | 33288 | 314 | 53315456 |
Incoherent | 21.43 | 12.94 | 20 | 33276 | 4652 | 53311118 |
Salivary hypersecretion | 21.42 | 12.94 | 24 | 33272 | 6919 | 53308851 |
Skull fracture | 21.35 | 12.94 | 11 | 33285 | 974 | 53314796 |
Sedation | 21.26 | 12.94 | 53 | 33243 | 29622 | 53286148 |
Hypertonia | 21.20 | 12.94 | 20 | 33276 | 4717 | 53311053 |
Orthostatic hypotension | 21.17 | 12.94 | 53 | 33243 | 29700 | 53286070 |
Impaired healing | 20.88 | 12.94 | 7 | 33289 | 64198 | 53251572 |
Hypomania | 20.68 | 12.94 | 20 | 33276 | 4862 | 53310908 |
Brain compression | 20.47 | 12.94 | 8 | 33288 | 368 | 53315402 |
Psoriatic arthropathy | 20.17 | 12.94 | 3 | 33293 | 48187 | 53267583 |
Psychotic disorder | 20.11 | 12.94 | 46 | 33250 | 24339 | 53291431 |
Cerebral infarction | 20.04 | 12.94 | 46 | 33250 | 24398 | 53291372 |
Drooling | 20.04 | 12.94 | 17 | 33279 | 3491 | 53312279 |
Executive dysfunction | 19.99 | 12.94 | 6 | 33290 | 122 | 53315648 |
Sinoatrial block | 19.93 | 12.94 | 10 | 33286 | 837 | 53314933 |
Catatonia | 19.91 | 12.94 | 18 | 33278 | 4022 | 53311748 |
Pyrexia | 19.77 | 12.94 | 159 | 33137 | 403034 | 52912736 |
Urticaria | 19.77 | 12.94 | 34 | 33262 | 135851 | 53179919 |
Vomiting | 19.51 | 12.94 | 426 | 32870 | 496713 | 52819057 |
Inappropriate affect | 19.47 | 12.94 | 10 | 33286 | 879 | 53314891 |
Hyponatraemic syndrome | 19.36 | 12.94 | 9 | 33287 | 637 | 53315133 |
Adams-Stokes syndrome | 19.35 | 12.94 | 5 | 33291 | 57 | 53315713 |
Peripheral swelling | 19.33 | 12.94 | 65 | 33231 | 206043 | 53109727 |
Non-24-hour sleep-wake disorder | 19.30 | 12.94 | 4 | 33292 | 15 | 53315755 |
Upper gastrointestinal haemorrhage | 19.18 | 12.94 | 37 | 33259 | 17393 | 53298377 |
Normal pressure hydrocephalus | 18.89 | 12.94 | 7 | 33289 | 278 | 53315492 |
Myalgia | 18.88 | 12.94 | 34 | 33262 | 133457 | 53182313 |
Paranoia | 18.82 | 12.94 | 29 | 33267 | 11395 | 53304375 |
Blood pressure orthostatic decreased | 18.75 | 12.94 | 5 | 33291 | 65 | 53315705 |
Intentional product use issue | 18.71 | 12.94 | 11 | 33285 | 72483 | 53243287 |
Antisocial behaviour | 18.70 | 12.94 | 7 | 33289 | 286 | 53315484 |
Death | 18.37 | 12.94 | 319 | 32977 | 356913 | 52958857 |
Injection site erythema | 18.19 | 12.94 | 13 | 33283 | 77236 | 53238534 |
Muscle contracture | 18.12 | 12.94 | 11 | 33285 | 1337 | 53314433 |
Foreign body | 17.97 | 12.94 | 13 | 33283 | 2118 | 53313652 |
Anaphylactic reaction | 17.87 | 12.94 | 7 | 33289 | 58319 | 53257451 |
Emotional poverty | 17.87 | 12.94 | 7 | 33289 | 324 | 53315446 |
Herbal interaction | 17.84 | 12.94 | 5 | 33291 | 79 | 53315691 |
Injection site pain | 17.78 | 12.94 | 27 | 33269 | 113364 | 53202406 |
Obsessive thoughts | 17.63 | 12.94 | 8 | 33288 | 535 | 53315235 |
Abnormal dreams | 17.59 | 12.94 | 27 | 33269 | 10574 | 53305196 |
Prescription drug used without a prescription | 17.58 | 12.94 | 12 | 33284 | 1782 | 53313988 |
Wound | 17.24 | 12.94 | 19 | 33277 | 91538 | 53224232 |
Affect lability | 17.16 | 12.94 | 25 | 33271 | 9350 | 53306420 |
Dyspepsia | 17.07 | 12.94 | 14 | 33282 | 77586 | 53238184 |
Aphasia | 17.06 | 12.94 | 50 | 33246 | 30728 | 53285042 |
Asthma | 17.04 | 12.94 | 26 | 33270 | 108946 | 53206824 |
Leukaemoid reaction | 17.02 | 12.94 | 6 | 33290 | 206 | 53315564 |
Pressure of speech | 16.86 | 12.94 | 8 | 33288 | 593 | 53315177 |
Liver function test abnormal | 16.85 | 12.94 | 67 | 33229 | 48004 | 53267766 |
Rash papulosquamous | 16.79 | 12.94 | 5 | 33291 | 99 | 53315671 |
Anorgasmia | 16.76 | 12.94 | 8 | 33288 | 601 | 53315169 |
Discomfort | 16.71 | 12.94 | 21 | 33275 | 95451 | 53220319 |
Paraesthesia | 16.70 | 12.94 | 34 | 33262 | 127481 | 53188289 |
Hypoglycaemia | 16.64 | 12.94 | 77 | 33219 | 58936 | 53256834 |
Duodenal ulcer haemorrhage | 16.31 | 12.94 | 13 | 33283 | 2447 | 53313323 |
Communication disorder | 16.30 | 12.94 | 13 | 33283 | 2448 | 53313322 |
Disease progression | 16.24 | 12.94 | 24 | 33272 | 101896 | 53213874 |
Intercepted product dispensing error | 16.16 | 12.94 | 5 | 33291 | 113 | 53315657 |
Hypoaesthesia | 16.14 | 12.94 | 37 | 33259 | 132958 | 53182812 |
Injection site reaction | 15.91 | 12.94 | 6 | 33290 | 51160 | 53264610 |
Fibromyalgia | 15.80 | 12.94 | 4 | 33292 | 44071 | 53271699 |
Neutropenia | 15.75 | 12.94 | 49 | 33247 | 159136 | 53156634 |
Irritable bowel syndrome | 15.57 | 12.94 | 4 | 33292 | 43628 | 53272142 |
Product use in unapproved indication | 15.52 | 12.94 | 29 | 33267 | 112260 | 53203510 |
Product dispensing error | 15.50 | 12.94 | 25 | 33271 | 10215 | 53305555 |
Arthritis | 15.49 | 12.94 | 19 | 33277 | 87279 | 53228491 |
Drop attacks | 15.17 | 12.94 | 8 | 33288 | 743 | 53315027 |
Haematoma | 15.09 | 12.94 | 51 | 33245 | 33793 | 53281977 |
Erythema | 15.06 | 12.94 | 49 | 33247 | 156920 | 53158850 |
Injection site swelling | 15.03 | 12.94 | 4 | 33292 | 42624 | 53273146 |
Gastric ulcer | 14.95 | 12.94 | 40 | 33256 | 23329 | 53292441 |
Dysphagia | 14.93 | 12.94 | 97 | 33199 | 84300 | 53231470 |
Delusion of grandeur | 14.79 | 12.94 | 5 | 33291 | 151 | 53315619 |
Gastric ulcer haemorrhage | 14.72 | 12.94 | 17 | 33279 | 5065 | 53310705 |
Libido increased | 14.69 | 12.94 | 9 | 33287 | 1112 | 53314658 |
Language disorder | 14.63 | 12.94 | 11 | 33285 | 1900 | 53313870 |
Pemphigoid | 14.53 | 12.94 | 19 | 33277 | 6425 | 53309345 |
Cholesteatoma | 14.52 | 12.94 | 5 | 33291 | 160 | 53315610 |
Heart rate increased | 14.51 | 12.94 | 18 | 33278 | 82297 | 53233473 |
Impaired self-care | 14.51 | 12.94 | 11 | 33285 | 1924 | 53313846 |
Blood glucose fluctuation | 14.50 | 12.94 | 16 | 33280 | 4535 | 53311235 |
Malignant neoplasm progression | 14.43 | 12.94 | 14 | 33282 | 71527 | 53244243 |
Amnesia | 14.21 | 12.94 | 61 | 33235 | 45227 | 53270543 |
Crying | 14.14 | 12.94 | 38 | 33258 | 22224 | 53293546 |
Neuropathy peripheral | 13.95 | 12.94 | 27 | 33269 | 103160 | 53212610 |
Opisthotonus | 13.95 | 12.94 | 6 | 33290 | 353 | 53315417 |
Nasal congestion | 13.87 | 12.94 | 8 | 33288 | 53279 | 53262491 |
Progressive supranuclear palsy | 13.74 | 12.94 | 4 | 33292 | 73 | 53315697 |
Acute abdomen | 13.72 | 12.94 | 10 | 33286 | 1648 | 53314122 |
Subdural haematoma | 13.61 | 12.94 | 28 | 33268 | 13785 | 53301985 |
Muscle twitching | 13.56 | 12.94 | 31 | 33265 | 16395 | 53299375 |
Visuospatial deficit | 13.46 | 12.94 | 3 | 33293 | 17 | 53315753 |
Thalamus haemorrhage | 13.46 | 12.94 | 7 | 33289 | 632 | 53315138 |
Hypoglycaemic coma | 13.41 | 12.94 | 12 | 33284 | 2646 | 53313124 |
Product blister packaging issue | 13.39 | 12.94 | 5 | 33291 | 203 | 53315567 |
Haematemesis | 13.32 | 12.94 | 46 | 33250 | 30811 | 53284959 |
Bundle branch block left | 13.27 | 12.94 | 19 | 33277 | 6994 | 53308776 |
Gait inability | 13.11 | 12.94 | 53 | 33243 | 38258 | 53277512 |
Apraxia | 13.10 | 12.94 | 10 | 33286 | 1768 | 53314002 |
Inflammation | 12.96 | 12.94 | 10 | 33286 | 57126 | 53258644 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hallucination | 379.43 | 14.39 | 313 | 23786 | 52306 | 32437121 |
Dementia | 369.74 | 14.39 | 186 | 23913 | 13200 | 32476227 |
Fall | 331.85 | 14.39 | 551 | 23548 | 195650 | 32293777 |
Bradycardia | 311.46 | 14.39 | 321 | 23778 | 71241 | 32418186 |
Confusional state | 271.67 | 14.39 | 424 | 23675 | 142691 | 32346736 |
Agitation | 185.19 | 14.39 | 220 | 23879 | 57016 | 32432411 |
Delusion | 184.10 | 14.39 | 117 | 23982 | 12991 | 32476436 |
Delirium | 146.87 | 14.39 | 172 | 23927 | 43874 | 32445553 |
Aggression | 136.65 | 14.39 | 157 | 23942 | 39232 | 32450195 |
Pleurothotonus | 129.10 | 14.39 | 43 | 24056 | 1038 | 32488389 |
Abnormal behaviour | 128.20 | 14.39 | 126 | 23973 | 26340 | 32463087 |
Cognitive disorder | 126.78 | 14.39 | 124 | 23975 | 25770 | 32463657 |
Cholinergic syndrome | 100.93 | 14.39 | 30 | 24069 | 492 | 32488935 |
Depressed level of consciousness | 94.34 | 14.39 | 133 | 23966 | 40714 | 32448713 |
Hallucination, visual | 93.12 | 14.39 | 87 | 24012 | 17072 | 32472355 |
Somnolence | 85.36 | 14.39 | 217 | 23882 | 103580 | 32385847 |
Mania | 83.58 | 14.39 | 64 | 24035 | 9568 | 32479859 |
Neuroleptic malignant syndrome | 82.30 | 14.39 | 82 | 24017 | 17413 | 32472014 |
Syncope | 78.90 | 14.39 | 193 | 23906 | 89931 | 32399496 |
Urinary incontinence | 74.19 | 14.39 | 79 | 24020 | 18128 | 32471299 |
Sinus node dysfunction | 69.28 | 14.39 | 41 | 24058 | 4003 | 32485424 |
Sinus bradycardia | 69.04 | 14.39 | 65 | 24034 | 12873 | 32476554 |
Dementia Alzheimer's type | 66.61 | 14.39 | 21 | 24078 | 423 | 32489004 |
Gait disturbance | 61.83 | 14.39 | 164 | 23935 | 80244 | 32409183 |
Memory impairment | 61.75 | 14.39 | 109 | 23990 | 40370 | 32449057 |
Febrile neutropenia | 61.52 | 14.39 | 8 | 24091 | 119558 | 32369869 |
Balance disorder | 59.86 | 14.39 | 106 | 23993 | 39353 | 32450074 |
Nightmare | 58.78 | 14.39 | 60 | 24039 | 13106 | 32476321 |
Blood cholinesterase decreased | 55.28 | 14.39 | 14 | 24085 | 121 | 32489306 |
Serotonin syndrome | 49.77 | 14.39 | 66 | 24033 | 19051 | 32470376 |
Pneumonia aspiration | 45.81 | 14.39 | 97 | 24002 | 41059 | 32448368 |
Parkinsonism | 44.81 | 14.39 | 41 | 24058 | 7828 | 32481599 |
Neutropenia | 44.55 | 14.39 | 25 | 24074 | 142150 | 32347277 |
Unresponsive to stimuli | 44.25 | 14.39 | 76 | 24023 | 27533 | 32461894 |
Tremor | 43.64 | 14.39 | 146 | 23953 | 81131 | 32408296 |
Prescribed underdose | 41.48 | 14.39 | 41 | 24058 | 8618 | 32480809 |
Poriomania | 41.05 | 14.39 | 11 | 24088 | 121 | 32489306 |
Extrapyramidal disorder | 40.50 | 14.39 | 47 | 24052 | 11848 | 32477579 |
Loss of consciousness | 40.42 | 14.39 | 144 | 23955 | 82563 | 32406864 |
Orthostatic hypotension | 40.31 | 14.39 | 70 | 24029 | 25580 | 32463847 |
Death | 39.67 | 14.39 | 445 | 23654 | 382072 | 32107355 |
Libido increased | 39.37 | 14.39 | 17 | 24082 | 848 | 32488579 |
Hyperhidrosis | 39.23 | 14.39 | 129 | 23970 | 71039 | 32418388 |
Myoclonus | 38.84 | 14.39 | 51 | 24048 | 14578 | 32474849 |
Disorientation | 37.45 | 14.39 | 79 | 24020 | 33346 | 32456081 |
Anal incontinence | 35.96 | 14.39 | 35 | 24064 | 7219 | 32482208 |
Dyskinesia | 35.26 | 14.39 | 63 | 24036 | 23540 | 32465887 |
Arthralgia | 35.06 | 14.39 | 35 | 24064 | 148413 | 32341014 |
Automatism | 34.18 | 14.39 | 9 | 24090 | 92 | 32489335 |
Jealous delusion | 33.08 | 14.39 | 11 | 24088 | 264 | 32489163 |
Restlessness | 32.88 | 14.39 | 63 | 24036 | 24818 | 32464609 |
Paranoia | 32.38 | 14.39 | 40 | 24059 | 10759 | 32478668 |
Mental status changes | 32.32 | 14.39 | 81 | 24018 | 38256 | 32451171 |
Hypersomnia | 32.22 | 14.39 | 42 | 24057 | 11919 | 32477508 |
Rhabdomyolysis | 31.90 | 14.39 | 116 | 23983 | 67149 | 32422278 |
Somatic delusion | 31.59 | 14.39 | 9 | 24090 | 126 | 32489301 |
Dizziness | 31.58 | 14.39 | 264 | 23835 | 209354 | 32280073 |
Lethargy | 31.56 | 14.39 | 84 | 24015 | 41144 | 32448283 |
Product prescribing issue | 31.45 | 14.39 | 16 | 24083 | 1159 | 32488268 |
Blood glucose fluctuation | 31.23 | 14.39 | 25 | 24074 | 3984 | 32485443 |
Salivary hypersecretion | 31.02 | 14.39 | 34 | 24065 | 8054 | 32481373 |
Intestinal haemorrhage | 30.51 | 14.39 | 23 | 24076 | 3356 | 32486071 |
Dyspnoea | 29.66 | 14.39 | 153 | 23946 | 361892 | 32127535 |
Bradyarrhythmia | 29.66 | 14.39 | 19 | 24080 | 2135 | 32487292 |
Parkinson's disease | 28.26 | 14.39 | 17 | 24082 | 1709 | 32487718 |
Abdominal pain | 28.18 | 14.39 | 42 | 24057 | 149487 | 32339940 |
Sexually inappropriate behaviour | 27.46 | 14.39 | 11 | 24088 | 453 | 32488974 |
Nonspecific reaction | 26.80 | 14.39 | 15 | 24084 | 1317 | 32488110 |
Drooling | 26.62 | 14.39 | 21 | 24078 | 3276 | 32486151 |
Electrocardiogram QT prolonged | 26.61 | 14.39 | 77 | 24022 | 39564 | 32449863 |
Hypothermia | 26.47 | 14.39 | 35 | 24064 | 10068 | 32479359 |
Dementia with Lewy bodies | 26.45 | 14.39 | 12 | 24087 | 674 | 32488753 |
Psychomotor hyperactivity | 26.33 | 14.39 | 33 | 24066 | 9006 | 32480421 |
Flight of ideas | 26.19 | 14.39 | 10 | 24089 | 362 | 32489065 |
Dysstasia | 25.89 | 14.39 | 37 | 24062 | 11449 | 32477978 |
Thrombocytopenia | 25.73 | 14.39 | 44 | 24055 | 148255 | 32341172 |
Miosis | 25.71 | 14.39 | 32 | 24067 | 8672 | 32480755 |
Drug abuse | 25.27 | 14.39 | 14 | 24085 | 80229 | 32409198 |
Seizure | 25.18 | 14.39 | 147 | 23952 | 103707 | 32385720 |
Muscle rigidity | 25.17 | 14.39 | 36 | 24063 | 11150 | 32478277 |
Hip fracture | 24.95 | 14.39 | 37 | 24062 | 11838 | 32477589 |
Drug interaction | 24.90 | 14.39 | 259 | 23840 | 217926 | 32271501 |
Neuropathy peripheral | 24.87 | 14.39 | 13 | 24086 | 76969 | 32412458 |
Gastrointestinal haemorrhage | 24.41 | 14.39 | 128 | 23971 | 86754 | 32402673 |
Muscle contractions involuntary | 24.08 | 14.39 | 16 | 24083 | 1912 | 32487515 |
Altered state of consciousness | 23.49 | 14.39 | 51 | 24048 | 21946 | 32467481 |
Atrioventricular block complete | 23.46 | 14.39 | 31 | 24068 | 8913 | 32480514 |
Contusion | 23.43 | 14.39 | 66 | 24033 | 33402 | 32456025 |
Pain | 23.22 | 14.39 | 67 | 24032 | 187489 | 32301938 |
Gait inability | 23.17 | 14.39 | 48 | 24051 | 19999 | 32469428 |
Dehydration | 23.01 | 14.39 | 169 | 23930 | 128789 | 32360638 |
Cerebral atrophy | 22.73 | 14.39 | 22 | 24077 | 4505 | 32484922 |
Neutrophil count decreased | 22.29 | 14.39 | 4 | 24095 | 47135 | 32442292 |
Irritability | 21.74 | 14.39 | 53 | 24046 | 24601 | 32464826 |
Daydreaming | 21.72 | 14.39 | 10 | 24089 | 581 | 32488846 |
Inappropriate antidiuretic hormone secretion | 21.72 | 14.39 | 35 | 24064 | 12028 | 32477399 |
Skin swelling | 21.67 | 14.39 | 12 | 24087 | 1032 | 32488395 |
Atrioventricular block first degree | 21.57 | 14.39 | 24 | 24075 | 5779 | 32483648 |
Hangover | 21.10 | 14.39 | 12 | 24087 | 1087 | 32488340 |
Femoral neck fracture | 21.07 | 14.39 | 18 | 24081 | 3138 | 32486289 |
Cold sweat | 20.91 | 14.39 | 31 | 24068 | 9915 | 32479512 |
Pruritus | 20.69 | 14.39 | 40 | 24059 | 128662 | 32360765 |
Blood glucose abnormal | 20.58 | 14.39 | 23 | 24076 | 5565 | 32483862 |
Gastrointestinal ulcer | 20.37 | 14.39 | 14 | 24085 | 1769 | 32487658 |
Septic shock | 20.36 | 14.39 | 13 | 24086 | 68976 | 32420451 |
Malignant neoplasm progression | 20.30 | 14.39 | 17 | 24082 | 78479 | 32410948 |
Subdural haematoma | 19.88 | 14.39 | 45 | 24054 | 19908 | 32469519 |
Executive dysfunction | 19.86 | 14.39 | 7 | 24092 | 201 | 32489226 |
Multiple organ dysfunction syndrome | 19.50 | 14.39 | 14 | 24085 | 69840 | 32419587 |
Intention tremor | 19.30 | 14.39 | 8 | 24091 | 360 | 32489067 |
Defect conduction intraventricular | 19.27 | 14.39 | 7 | 24092 | 220 | 32489207 |
Paraesthesia | 18.97 | 14.39 | 10 | 24089 | 58934 | 32430493 |
Speech disorder | 18.59 | 14.39 | 52 | 24047 | 26201 | 32463226 |
Urinary tract infection | 18.53 | 14.39 | 112 | 23987 | 79959 | 32409468 |
Gastroenteritis pseudomonas | 18.41 | 14.39 | 4 | 24095 | 16 | 32489411 |
Duodenal ulcer | 18.37 | 14.39 | 30 | 24069 | 10425 | 32479002 |
Decreased appetite | 18.36 | 14.39 | 191 | 23908 | 160622 | 32328805 |
Hiccups | 18.21 | 14.39 | 29 | 24070 | 9866 | 32479561 |
Posture abnormal | 17.77 | 14.39 | 14 | 24085 | 2179 | 32487248 |
Potentiating drug interaction | 17.40 | 14.39 | 20 | 24079 | 4988 | 32484439 |
Behaviour disorder | 17.06 | 14.39 | 17 | 24082 | 3607 | 32485820 |
Condition aggravated | 16.89 | 14.39 | 183 | 23916 | 155478 | 32333949 |
Leukopenia | 16.84 | 14.39 | 12 | 24087 | 60110 | 32429317 |
Rheumatoid arthritis | 16.80 | 14.39 | 6 | 24093 | 44538 | 32444889 |
Atrioventricular block | 16.29 | 14.39 | 24 | 24075 | 7631 | 32481796 |
Foaming at mouth | 16.02 | 14.39 | 9 | 24090 | 796 | 32488631 |
Underdose | 15.94 | 14.39 | 32 | 24067 | 13037 | 32476390 |
Multiple drug therapy | 15.88 | 14.39 | 7 | 24092 | 367 | 32489060 |
Tardive dyskinesia | 15.80 | 14.39 | 20 | 24079 | 5511 | 32483916 |
Impulsive behaviour | 15.68 | 14.39 | 13 | 24086 | 2176 | 32487251 |
Incontinence | 15.53 | 14.39 | 20 | 24079 | 5606 | 32483821 |
Drug hypersensitivity | 15.44 | 14.39 | 19 | 24080 | 73381 | 32416046 |
Urticaria | 15.30 | 14.39 | 13 | 24086 | 59601 | 32429826 |
Post-traumatic stress disorder | 15.28 | 14.39 | 12 | 24087 | 1859 | 32487568 |
Pyrexia | 15.12 | 14.39 | 158 | 23941 | 319810 | 32169617 |
Loss of personal independence in daily activities | 15.09 | 14.39 | 49 | 24050 | 26784 | 32462643 |
Hypernatraemia | 14.97 | 14.39 | 24 | 24075 | 8209 | 32481218 |
Hypomania | 14.60 | 14.39 | 13 | 24086 | 2396 | 32487031 |
Musculoskeletal pain | 14.46 | 14.39 | 3 | 24096 | 31894 | 32457533 |
Frontotemporal dementia | 14.39 | 14.39 | 6 | 24093 | 274 | 32489153 |
Source | Code | Description |
---|---|---|
ATC | N06DA02 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTI-DEMENTIA DRUGS Anticholinesterases |
ATC | N06DA52 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTI-DEMENTIA DRUGS Anticholinesterases |
ATC | N06DA53 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTI-DEMENTIA DRUGS Anticholinesterases |
FDA MoA | N0000000177 | Cholinesterase Inhibitors |
CHEBI has role | CHEBI:38462 | acetylcholine esterase inhibitor |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D018678 | Cholinergic Agents |
MeSH PA | D002800 | Cholinesterase Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018697 | Nootropic Agents |
FDA EPC | N0000175723 | Cholinesterase Inhibitor |
CHEBI has role | CHEBI:37733 | BChE inhibitor |
CHEBI has role | CHEBI:66980 | nootropics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Alzheimer's disease | indication | 26929004 | DOID:10652 |
Moderate to Severe Alzheimer's Type Dementia | indication | ||
Diffuse Lewy body disease | off-label use | 80098002 | |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Sinus bradycardia | contraindication | 49710005 | |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Asthma | contraindication | 195967001 | DOID:2841 |
Atrioventricular block | contraindication | 233917008 | DOID:0050820 |
Bladder outflow obstruction | contraindication | 236645006 | |
NSAID-Induced Gastric Ulcer | contraindication | ||
Chronic Obstructive Pulmonary Disease with Bronchospasms | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.4 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8173708 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8283379 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8338486 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8362085 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580858 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8173708 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8283379 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8338486 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8362085 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580858 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8173708 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8283379 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8338486 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8362085 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580858 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8173708 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8283379 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8338486 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8362085 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580858 | Nov. 22, 2025 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8039009 | March 24, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8039009 | March 24, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8039009 | March 24, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8039009 | March 24, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;14MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8058291 | Dec. 5, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;21MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8058291 | Dec. 5, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;28MG | NAMZARIC | ALLERGAN | N206439 | Dec. 23, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8058291 | Dec. 5, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
10MG;7MG | NAMZARIC | ALLERGAN | N206439 | July 18, 2016 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8058291 | Dec. 5, 2029 | MEMANTINE HCL/DONEPEZIL HCL COMBINATION FOR THE TREATMENT OF MODERATE TO SEVERE DEMENTIA OF THE ALZHEIMERS TYPE |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase | Enzyme | INHIBITOR | Ki | 7.80 | WOMBAT-PK | CHEMBL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.70 | CHEMBL | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 4.46 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.05 | WOMBAT-PK | |||||
Amine oxidase [flavin-containing] B | Enzyme | IC50 | 4.82 | CHEMBL | |||||
Cholinesterase | Enzyme | Ki | 4.90 | CHEMBL | |||||
Histamine H3 receptor | GPCR | IC50 | 6.46 | CHEMBL | |||||
Beta-secretase 1 | Enzyme | IC50 | 5.49 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.84 | CHEMBL | |||||
Acetylcholinesterase | Enzyme | IC50 | 8.24 | CHEMBL | |||||
Acetylcholinesterase | Enzyme | IC50 | 8.24 | CHEMBL | |||||
Butyrylcholinesterase; Protein Bche | Enzyme | IC50 | 5.56 | CHEMBL | |||||
Acetylcholinesterase | Enzyme | IC50 | 8.77 | CHEMBL | |||||
Acetylcholinesterase | Enzyme | Ki | 7.25 | CHEMBL | |||||
Acetylcholinesterase | Enzyme | Ki | 8.54 | CHEMBL | |||||
Choline O-acetyltransferase | Enzyme | IC50 | 8.28 | CHEMBL | |||||
Amine oxidase [flavin-containing] B | Enzyme | IC50 | 4.82 | CHEMBL | |||||
Cholinesterase | Enzyme | IC50 | 5.15 | CHEMBL | |||||
Butyrylcholinesterase | Enzyme | Ki | 6.19 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane other | Ki | 7.84 | CHEMBL | |||||
Cholinesterase | Enzyme | IC50 | 6.08 | CHEMBL |
ID | Source |
---|---|
D00670 | KEGG_DRUG |
120011-70-3 | SECONDARY_CAS_RN |
4021006 | VANDF |
4024045 | VANDF |
C0527316 | UMLSCUI |
CHEBI:53289 | CHEBI |
E20 | PDB_CHEM_ID |
CHEMBL502 | ChEMBL_ID |
CHEMBL1678 | ChEMBL_ID |
DB00843 | DRUGBANK_ID |
D000077265 | MESH_DESCRIPTOR_UI |
3152 | PUBCHEM_CID |
6599 | IUPHAR_LIGAND_ID |
7517 | INN_ID |
8SSC91326P | UNII |
135446 | RXNORM |
15004 | MMSL |
178540 | MMSL |
4631 | MMSL |
6432 | MMSL |
d04099 | MMSL |
006295 | NDDF |
006296 | NDDF |
108497001 | SNOMEDCT_US |
386855006 | SNOMEDCT_US |
386856007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9747 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 24 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9748 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 24 sections |
Namzaric | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0456-1207 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Namzaric | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0456-1214 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Namzaric | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0456-1221 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Namzaric | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0456-1228 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7951 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 18 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7952 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 18 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8313 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 19 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5276 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 26 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5277 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 26 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6477 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 24 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6478 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 24 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-102 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 25 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-103 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
Donepezil Hydrochloride | Human Prescription Drug Label | 1 | 16571-778 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
Donepezil Hydrochloride | Human Prescription Drug Label | 1 | 16571-779 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
DONEPEZIL HYDROCHLORIDE | Human Prescription Drug Label | 1 | 24724-028 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 25 sections |
DONEPEZIL HYDROCHLORIDE | Human Prescription Drug Label | 1 | 24724-029 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24979-004 | TABLET, FILM COATED | 23 mg | ORAL | ANDA | 16 sections |
donepezil hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-248 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 23 sections |
donepezil hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-249 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 23 sections |
donepezil hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-250 | TABLET, ORALLY DISINTEGRATING | 5 mg | ORAL | ANDA | 23 sections |
donepezil hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-251 | TABLET, ORALLY DISINTEGRATING | 10 mg | ORAL | ANDA | 23 sections |
Donepezil hydrochloride | Human Prescription Drug Label | 1 | 31722-139 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 25 sections |
Donepezil hydrochloride | Human Prescription Drug Label | 1 | 31722-140 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
Donepezil | Human Prescription Drug Label | 1 | 31722-737 | TABLET | 5 mg | ORAL | ANDA | 19 sections |
Donepezil | Human Prescription Drug Label | 1 | 31722-738 | TABLET | 10 mg | ORAL | ANDA | 19 sections |
Donepezil Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-817 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 19 sections |
Donepezil Hydrochloride | Human Prescription Drug Label | 1 | 33342-027 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 18 sections |