domperidone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antipsychotics, risperidone derivatives 945 57808-66-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • domperidone betadex
  • domperidone betacyclodextrin
  • domperidone
  • motilium
  • peridon
  • domperidone maleate
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
  • Molecular weight: 425.92
  • Formula: C22H24ClN5O2
  • CLOGP: 3.87
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 67.92
  • ALOGS: -3.66
  • ROTB: 5

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P
0.12 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.34 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.08 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1982 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature labour 154.57 11.89 94 31750 11382 50561898
Derealisation 129.09 11.89 41 31803 1005 50572275
Gastric pH decreased 124.97 11.89 36 31808 626 50572654
Depersonalisation/derealisation disorder 111.74 11.89 38 31806 1160 50572120
H1N1 influenza 90.29 11.89 35 31809 1562 50571718
Cogwheel rigidity 86.66 11.89 35 31809 1742 50571538
Dissociation 84.53 11.89 37 31807 2254 50571026
Feeling of despair 82.36 11.89 35 31809 1983 50571297
Hypoaesthesia oral 82.28 11.89 62 31782 10666 50562614
Hyperprolactinaemia 76.76 11.89 39 31805 3326 50569954
Drug ineffective 73.20 11.89 268 31576 819065 49754215
Pulmonary malformation 70.85 11.89 18 31826 189 50573091
Completed suicide 66.96 11.89 4 31840 131885 50441395
Sensory loss 66.74 11.89 48 31796 7690 50565590
Drooling 65.13 11.89 35 31809 3349 50569931
Systemic lupus erythematosus 63.83 11.89 7 31837 140615 50432665
Muscle disorder 62.10 11.89 37 31807 4313 50568967
Pituitary tumour benign 60.04 11.89 27 31817 1754 50571526
Feeling of body temperature change 59.38 11.89 36 31808 4331 50568949
Vomiting 58.76 11.89 492 31352 460266 50113014
Menstrual disorder 56.80 11.89 35 31809 4335 50568945
Parosmia 56.32 11.89 35 31809 4401 50568879
Hallucinations, mixed 56.24 11.89 34 31810 4069 50569211
Cestode infection 55.93 11.89 16 31828 271 50573009
Restless legs syndrome 55.74 11.89 59 31785 15838 50557442
Product dose omission issue 54.07 11.89 24 31820 183814 50389466
Nightmare 53.41 11.89 58 31786 16028 50557252
Dyskinesia 53.06 11.89 76 31768 27785 50545495
Therapeutic product ineffective 51.74 11.89 22 31822 1248 50572032
Muscle rigidity 50.51 11.89 45 31799 9784 50563496
Gangrene 49.62 11.89 33 31811 4659 50568621
On and off phenomenon 49.50 11.89 22 31822 1390 50571890
Mydriasis 49.42 11.89 46 31798 10581 50562699
Arterial occlusive disease 48.89 11.89 33 31811 4775 50568505
Mood swings 48.62 11.89 55 31789 15899 50557381
Schizophrenia 48.58 11.89 39 31805 7358 50565922
Stoma site erythema 48.50 11.89 19 31825 872 50572408
Stoma site discharge 48.37 11.89 21 31823 1254 50572026
Contraindicated product administered 47.80 11.89 17 31827 148941 50424339
Psychotic disorder 46.77 11.89 63 31781 21749 50551531
Dystonia 46.76 11.89 47 31797 11879 50561401
Arthropathy 45.82 11.89 21 31823 157885 50415395
Decreased appetite 45.75 11.89 248 31596 200675 50372605
Synovitis 45.48 11.89 11 31833 123854 50449426
Lung cyst 44.47 11.89 12 31832 162 50573118
Hypersensitivity 44.37 11.89 42 31802 215119 50358161
Neutropenic sepsis 43.50 11.89 49 31795 14098 50559182
Therapeutic product effect decreased 42.85 11.89 16 31828 136034 50437246
Electrocardiogram QT prolonged 42.43 11.89 98 31746 51788 50521492
Abdominal discomfort 41.35 11.89 51 31793 231590 50341690
Respiratory tract malformation 41.05 11.89 10 31834 87 50573193
Glossodynia 41.01 11.89 11 31833 115558 50457722
Akathisia 40.95 11.89 37 31807 8192 50565088
Forced vital capacity decreased 40.67 11.89 17 31827 924 50572356
Lung diffusion test decreased 40.39 11.89 15 31829 594 50572686
Premenstrual syndrome 40.32 11.89 15 31829 597 50572683
Neuroleptic malignant syndrome 40.26 11.89 42 31802 11088 50562192
Inguinal hernia 39.58 11.89 20 31824 1686 50571594
Magnesium deficiency 39.45 11.89 14 31830 486 50572794
Paralysis 39.32 11.89 37 31807 8627 50564653
Rash 38.90 11.89 143 31701 437328 50135952
Basal ganglion degeneration 38.28 11.89 13 31831 395 50572885
Pericarditis 38.14 11.89 3 31841 78686 50494594
Maternal exposure during pregnancy 38.13 11.89 27 31817 159751 50413529
Tissue infiltration 38.08 11.89 14 31830 539 50572741
Lip pruritus 37.50 11.89 15 31829 728 50572552
Secondary adrenocortical insufficiency 37.49 11.89 17 31827 1126 50572154
Emotional disorder 34.70 11.89 40 31804 11796 50561484
Hallucination, auditory 34.43 11.89 38 31806 10690 50562590
Wound 34.06 11.89 12 31832 105782 50467498
Mania 33.89 11.89 38 31806 10878 50562402
Lichen sclerosus 33.42 11.89 15 31829 970 50572310
Hepatic enzyme increased 33.06 11.89 23 31821 137357 50435923
Hand deformity 32.89 11.89 11 31833 100188 50473092
Hyperchlorhydria 32.80 11.89 17 31827 1511 50571769
Skin discolouration 32.63 11.89 67 31777 32690 50540590
Serotonin syndrome 32.62 11.89 57 31787 24656 50548624
Total lung capacity decreased 32.50 11.89 16 31828 1275 50572005
Maternal exposure during breast feeding 32.29 11.89 22 31822 3232 50570048
Uterine enlargement 32.28 11.89 15 31829 1051 50572229
Exposure via breast milk 31.98 11.89 17 31827 1591 50571689
Polymenorrhoea 31.69 11.89 15 31829 1096 50572184
Incontinence 31.41 11.89 35 31809 9950 50563330
Tinnitus 30.97 11.89 60 31784 28072 50545208
Menstruation delayed 30.94 11.89 16 31828 1415 50571865
Blood sodium decreased 30.85 11.89 51 31793 21096 50552184
Treatment failure 29.38 11.89 26 31818 137611 50435669
Biliary sepsis 29.02 11.89 13 31831 837 50572443
Body temperature fluctuation 28.73 11.89 17 31827 1956 50571324
Paranoia 28.72 11.89 34 31810 10314 50562966
Anti-cyclic citrullinated peptide antibody positive 28.52 11.89 5 31839 70582 50502698
Cyanosis 28.29 11.89 41 31803 15143 50558137
Subileus 28.20 11.89 19 31825 2740 50570540
Anaesthesia 28.10 11.89 10 31834 350 50572930
Bronchopulmonary aspergillosis allergic 27.74 11.89 14 31830 1177 50572103
Unresponsive to stimuli 27.46 11.89 60 31784 30549 50542731
Chronic sinusitis 27.42 11.89 26 31818 6119 50567161
Abdominal tenderness 27.28 11.89 28 31816 7252 50566028
Thyroid stimulating immunoglobulin increased 27.17 11.89 7 31837 78 50573202
Blepharospasm 27.06 11.89 19 31825 2929 50570351
Freezing phenomenon 26.81 11.89 13 31831 1002 50572278
Mental disorder 26.81 11.89 49 31795 21942 50551338
Joint swelling 26.79 11.89 73 31771 245213 50328067
Rhinalgia 26.68 11.89 13 31831 1013 50572267
Feeling jittery 26.66 11.89 34 31810 11126 50562154
Nail dystrophy 26.40 11.89 12 31832 799 50572481
Stoma site hypergranulation 26.30 11.89 9 31835 280 50573000
Folate deficiency 26.28 11.89 16 31828 1939 50571341
Hypokalaemia 25.96 11.89 117 31727 87875 50485405
Gastritis fungal 25.77 11.89 7 31837 97 50573183
Adrenal suppression 25.57 11.89 12 31832 860 50572420
Discomfort 24.96 11.89 19 31825 108361 50464919
Cardiac failure congestive 24.81 11.89 11 31833 84371 50488909
Restlessness 24.49 11.89 51 31793 25122 50548158
Neuropathy peripheral 24.44 11.89 123 31721 96634 50476646
Adverse drug reaction 24.42 11.89 3 31841 55219 50518061
Tremor 24.22 11.89 139 31705 114764 50458516
Limbic encephalitis 24.14 11.89 8 31836 225 50573055
Vascular encephalopathy 23.67 11.89 9 31835 381 50572899
Lung opacity 23.62 11.89 15 31829 1958 50571322
Torsade de pointes 23.58 11.89 33 31811 11802 50561478
Stoma site pain 23.39 11.89 11 31833 792 50572488
Constipation 23.37 11.89 198 31646 185510 50387770
Stoma site inflammation 23.29 11.89 9 31835 398 50572882
Infection 23.28 11.89 46 31798 172908 50400372
Glomerulonephritis chronic 23.10 11.89 7 31837 146 50573134
Pallor 22.57 11.89 47 31797 23152 50550128
Pulmonary function test decreased 22.54 11.89 18 31826 3370 50569910
Heart rate increased 22.25 11.89 102 31742 77148 50496132
Suicidal ideation 22.20 11.89 81 31763 55304 50517976
Urinary retention 21.99 11.89 50 31794 26140 50547140
Febrile neutropenia 21.81 11.89 120 31724 97547 50475733
Delirium 21.77 11.89 63 31781 38129 50535151
Psychogenic seizure 21.38 11.89 13 31831 1572 50571708
Overdose 21.08 11.89 19 31825 99708 50473572
Hypochromic anaemia 20.57 11.89 13 31831 1683 50571597
Adrenal insufficiency 20.31 11.89 34 31810 14209 50559071
Swelling 20.30 11.89 62 31782 200810 50372470
Irritable bowel syndrome 20.02 11.89 4 31840 51437 50521843
Terminal ileitis 19.76 11.89 9 31835 602 50572678
Speech disorder 19.65 11.89 58 31786 35490 50537790
Stoma site infection 19.62 11.89 9 31835 612 50572668
Neurological decompensation 19.39 11.89 14 31830 2256 50571024
Oral cavity fistula 19.32 11.89 9 31835 634 50572646
Pyrexia 19.26 11.89 341 31503 379862 50193418
Rheumatoid factor positive 19.15 11.89 4 31840 49855 50523425
Sputum discoloured 19.13 11.89 32 31812 13363 50559917
Gastric disorder 19.07 11.89 51 31793 29497 50543783
Galactorrhoea 19.04 11.89 17 31827 3706 50569574
Stoma complication 18.98 11.89 7 31837 272 50573008
Monoplegia 18.97 11.89 15 31829 2768 50570512
Axillary pain 18.86 11.89 12 31832 1572 50571708
Carcinoid tumour 18.30 11.89 7 31837 301 50572979
Nail bed tenderness 17.85 11.89 7 31837 322 50572958
Disorientation 17.84 11.89 56 31788 35428 50537852
Impaired healing 17.70 11.89 11 31833 69775 50503505
Chest discomfort 17.51 11.89 109 31735 92613 50480667
Injection site erythema 17.42 11.89 13 31831 74923 50498357
Feeling abnormal 17.21 11.89 33 31811 125459 50447821
Hypomagnesaemia 17.05 11.89 42 31802 23114 50550166
Acute hepatic failure 16.72 11.89 33 31811 15644 50557636
Lung disorder 16.68 11.89 64 31780 44735 50528545
Infusion site vesicles 16.56 11.89 7 31837 391 50572889
Vision blurred 16.47 11.89 95 31749 78552 50494728
Off label use 16.32 11.89 402 31442 474024 50099256
Anti-thyroid antibody positive 16.27 11.89 7 31837 409 50572871
Dementia 16.26 11.89 33 31811 15964 50557316
Aphasia 16.24 11.89 47 31797 28447 50544833
Abdominal pain 16.18 11.89 223 31621 236005 50337275
Weight decreased 16.04 11.89 211 31633 221034 50352246
Drug withdrawal syndrome 15.89 11.89 43 31801 25038 50548242
Stoma site extravasation 15.87 11.89 6 31838 250 50573030
Epilepsy 15.75 11.89 39 31805 21528 50551752
Psoriatic arthropathy 15.71 11.89 5 31839 47027 50526253
Angina pectoris 15.70 11.89 44 31800 26144 50547136
Renal failure 15.55 11.89 27 31817 106606 50466674
Bezoar 15.52 11.89 10 31834 1338 50571942
Gastrointestinal sounds abnormal 15.50 11.89 15 31829 3619 50569661
Autonomic neuropathy 15.47 11.89 9 31835 1004 50572276
Dermatitis exfoliative generalised 15.44 11.89 14 31830 3112 50570168
Therapeutic product effect incomplete 15.42 11.89 21 31823 91494 50481786
Folliculitis 15.37 11.89 3 31841 39222 50534058
Duodenal stenosis 15.09 11.89 7 31837 489 50572791
Dysaesthesia pharynx 15.01 11.89 5 31839 143 50573137
Oral candidiasis 14.99 11.89 33 31811 16882 50556398
Injury 14.98 11.89 6 31838 48919 50524361
Taste disorder 14.82 11.89 22 31822 8302 50564978
Cataract 14.78 11.89 64 31780 47236 50526044
Sprue-like enteropathy 14.73 11.89 7 31837 516 50572764
Mucosal inflammation 14.66 11.89 57 31787 40085 50533195
Repetitive strain injury 14.63 11.89 5 31839 155 50573125
Thyroxine free increased 14.62 11.89 8 31836 793 50572487
Microvillous inclusion disease 14.50 11.89 3 31841 11 50573269
Paraesthesia 14.48 11.89 127 31717 120116 50453164
Cardio-respiratory arrest 14.37 11.89 8 31836 53884 50519396
Hospitalisation 14.29 11.89 13 31831 67924 50505356
Needle issue 14.07 11.89 20 31824 7255 50566025
Ejection fraction decreased 14.07 11.89 34 31810 18486 50554794
Impaired gastric emptying 14.05 11.89 22 31822 8696 50564584
Vulvovaginal pruritus 13.97 11.89 12 31832 2484 50570796
Functional residual capacity decreased 13.97 11.89 4 31840 68 50573212
Sleep disorder 13.88 11.89 72 31772 57211 50516069
Gingival pain 13.88 11.89 18 31826 5988 50567292
Injection site pustule 13.86 11.89 4 31840 70 50573210
Intention tremor 13.82 11.89 6 31838 358 50572922
Helicobacter infection 13.81 11.89 7 31837 49695 50523585
Hyperpyrexia 13.79 11.89 13 31831 3036 50570244
Hypothyroidism 13.75 11.89 50 31794 34075 50539205
Wrong technique in product usage process 13.74 11.89 9 31835 55501 50517779
Disturbance in attention 13.69 11.89 47 31797 31139 50542141
Infertility 13.68 11.89 7 31837 606 50572674
Psoriasis 13.59 11.89 14 31830 68986 50504294
Illness 13.52 11.89 40 31804 24500 50548780
Eye pain 13.48 11.89 44 31800 28405 50544875
Myopathy 13.27 11.89 22 31822 9117 50564163
Pseudocholinesterase deficiency 13.22 11.89 4 31840 83 50573197
Limb injury 13.11 11.89 35 31809 20215 50553065
Pancreatitis chronic 13.10 11.89 11 31833 2209 50571071
Internal haemorrhage 13.07 11.89 15 31829 4402 50568878
Aspiration 13.05 11.89 22 31822 9242 50564038
Poor sucking reflex 13.03 11.89 5 31839 217 50573063
Fibromyalgia 13.00 11.89 6 31838 44972 50528308
Exposed bone in jaw 12.79 11.89 12 31832 2788 50570492
Catheter site haemorrhage 12.75 11.89 12 31832 2798 50570482
Dysphagia 12.73 11.89 88 31756 77430 50495850
Odynophagia 12.70 11.89 18 31826 6514 50566766
Onychoclasis 12.68 11.89 16 31828 5180 50568100
Hypoaesthesia 12.62 11.89 129 31715 127128 50446152
Pharyngeal hypoaesthesia 12.41 11.89 5 31839 247 50573033
Sclerodactylia 12.41 11.89 4 31840 103 50573177
Arthritis 12.26 11.89 95 31749 86626 50486654
Aphthous ulcer 12.15 11.89 23 31821 10574 50562706
Pneumonia aspiration 12.13 11.89 45 31799 30959 50542321
Aortic embolus 11.94 11.89 3 31841 30 50573250
Salivary gland cancer stage IV 11.94 11.89 3 31841 30 50573250
Mucosal haemorrhage 11.93 11.89 7 31837 793 50572487
Neck pain 11.91 11.89 11 31833 57056 50516224

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
On and off phenomenon 68.12 13.65 26 10966 1902 29561633
Regurgitation 66.23 13.65 23 10969 1284 29562251
Oropharyngeal discomfort 44.98 13.65 21 10971 2535 29561000
Vitamin B12 deficiency 42.94 13.65 22 10970 3249 29560286
Eructation 41.47 13.65 23 10969 3983 29559552
Stoma site discharge 38.37 13.65 14 10978 903 29562632
Stoma site erythema 35.41 13.65 12 10980 622 29562913
Intentional medical device removal by patient 33.81 13.65 9 10983 201 29563334
Vomiting 31.62 13.65 159 10833 212101 29351434
Device dislocation 31.21 13.65 20 10972 4507 29559028
Hyperkinesia 30.83 13.65 14 10978 1585 29561950
Oesophagitis 29.94 13.65 29 10963 11894 29551641
Dyspepsia 28.85 13.65 45 10947 30080 29533455
Oesophageal haemorrhage 28.42 13.65 12 10980 1141 29562394
Stoma site inflammation 27.38 13.65 9 10983 424 29563111
Saliva altered 26.40 13.65 7 10985 154 29563381
Drug ineffective 25.78 13.65 61 10931 363109 29200426
Akinesia 25.01 13.65 13 10979 1977 29561558
Impaired gastric emptying 24.79 13.65 15 10977 3055 29560480
Aspiration 24.14 13.65 24 10968 10156 29553379
Cataract 23.65 13.65 35 10957 22343 29541192
Dysphagia 22.00 13.65 57 10935 54869 29508666
Stoma site pain 22.00 13.65 8 10984 511 29563024
Impulse-control disorder 21.35 13.65 10 10982 1215 29562320
Toxicity to various agents 21.20 13.65 20 10972 173641 29389894
Freezing phenomenon 21.06 13.65 10 10982 1253 29562282
Electrocardiogram QT prolonged 19.35 13.65 42 10950 36095 29527440
Embedded device 19.34 13.65 6 10986 234 29563301
Lower respiratory tract infection 19.25 13.65 35 10957 26467 29537068
Dyskinesia 19.24 13.65 30 10962 20031 29543504
Inappropriate antidiuretic hormone secretion 19.24 13.65 22 10970 10910 29552625
Paralysis recurrent laryngeal nerve 18.20 13.65 4 10988 38 29563497
Pneumonia aspiration 17.77 13.65 41 10951 36696 29526839
Completed suicide 17.25 13.65 6 10986 90240 29473295
Sputum increased 17.08 13.65 10 10982 1917 29561618
Dyskinesia oesophageal 16.99 13.65 4 10988 53 29563482
Gastroenteritis 16.71 13.65 22 10970 12594 29550941
Stoma site infection 16.28 13.65 7 10985 696 29562839
Bradykinesia 16.13 13.65 12 10980 3435 29560100
Fanconi syndrome 16.06 13.65 9 10983 1589 29561946
Dermatitis atopic 15.78 13.65 10 10982 2209 29561326
Skin erosion 15.37 13.65 9 10983 1727 29561808
Shock symptom 15.08 13.65 4 10988 88 29563447
Renal tubular acidosis 15.05 13.65 9 10983 1794 29561741
Post inflammatory pigmentation change 15.02 13.65 5 10987 245 29563290
Lumbosacral plexus injury 14.86 13.65 3 10989 18 29563517
General physical health deterioration 14.52 13.65 76 10916 102781 29460754
Pyroglutamic acidosis 14.48 13.65 5 10987 274 29563261
Device related infection 14.47 13.65 23 10969 15613 29547922
Colitis ischaemic 14.31 13.65 14 10978 5809 29557726
Drug abuse 14.12 13.65 6 10986 79877 29483658

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastric pH decreased 116.86 11.68 35 40604 700 64457393
Derealisation 114.67 11.68 41 40598 1454 64456639
Completed suicide 105.12 11.68 10 40629 224404 64233689
Depersonalisation/derealisation disorder 100.03 11.68 38 40601 1602 64456491
On and off phenomenon 90.68 11.68 40 40599 2479 64455614
Premature labour 86.40 11.68 56 40583 7564 64450529
Drug ineffective 81.20 11.68 266 40373 839981 63618112
Vomiting 78.97 11.68 605 40034 550512 63907581
H1N1 influenza 78.42 11.68 35 40604 2231 64455862
Hypoaesthesia oral 78.00 11.68 62 40577 11518 64446575
Dissociation 74.82 11.68 37 40602 2974 64455119
Feeling of despair 74.23 11.68 35 40604 2533 64455560
Cogwheel rigidity 70.72 11.68 35 40604 2818 64455275
Hyperprolactinaemia 67.07 11.68 38 40601 4027 64454066
Menstrual disorder 65.27 11.68 35 40604 3330 64454763
Stoma site discharge 64.75 11.68 28 40611 1654 64456439
Stoma site erythema 62.45 11.68 25 40614 1214 64456879
Muscle disorder 57.64 11.68 37 40602 4914 64453179
Parosmia 57.32 11.68 36 40603 4604 64453489
Sensory loss 57.12 11.68 49 40590 10120 64447973
Feeling of body temperature change 56.11 11.68 36 40603 4778 64453315
Dyskinesia 56.06 11.68 94 40545 39294 64418799
Restless legs syndrome 55.52 11.68 61 40578 17055 64441038
Pituitary tumour benign 53.51 11.68 27 40612 2266 64455827
Cestode infection 51.93 11.68 15 40624 263 64457830
Pulmonary malformation 51.28 11.68 13 40626 135 64457958
Dystonia 50.68 11.68 61 40578 18804 64439289
Drooling 50.47 11.68 35 40604 5284 64452809
Mood swings 49.43 11.68 58 40581 17410 64440683
Electrocardiogram QT prolonged 48.09 11.68 134 40505 79314 64378779
Therapeutic product ineffective 48.01 11.68 22 40617 1491 64456602
Product dose omission issue 47.80 11.68 32 40607 194715 64263378
Neutropenic sepsis 45 11.68 64 40575 23208 64434885
Toxicity to various agents 44.73 11.68 102 40537 363411 64094682
Gangrene 44.59 11.68 37 40602 7301 64450792
Hallucinations, mixed 44.21 11.68 34 40605 6018 64452075
Decreased appetite 43.63 11.68 315 40324 280974 64177119
Premenstrual syndrome 42.58 11.68 15 40624 509 64457584
Arterial occlusive disease 39.72 11.68 34 40605 6999 64451094
Schizophrenia 38.31 11.68 41 40598 11127 64446966
Lip pruritus 38.24 11.68 15 40624 690 64457403
Muscle rigidity 38.22 11.68 51 40588 17422 64440671
Magnesium deficiency 37.81 11.68 14 40625 549 64457544
Mydriasis 37.09 11.68 47 40592 15265 64442828
Drug abuse 36.35 11.68 19 40620 132355 64325738
Skin discolouration 36.10 11.68 73 40566 35182 64422911
Lung cyst 35.65 11.68 10 40629 157 64457936
Akathisia 35.57 11.68 40 40599 11470 64446623
Arthropathy 35.29 11.68 16 40623 120951 64337142
Lichen sclerosus 34.75 11.68 15 40624 882 64457211
Polymenorrhoea 34.54 11.68 15 40624 895 64457198
Emotional disorder 34.25 11.68 41 40598 12566 64445527
Menstruation delayed 34.12 11.68 16 40623 1143 64456950
Paralysis 33.64 11.68 39 40600 11556 64446537
Hallucination, auditory 33.36 11.68 47 40592 16892 64441201
Exposure via breast milk 33.15 11.68 14 40625 780 64457313
Synovitis 32.37 11.68 11 40628 99079 64359014
Psychotic disorder 32.36 11.68 69 40570 34509 64423584
Mental disorder 31.03 11.68 58 40581 26387 64431706
Therapeutic product effect decreased 31.02 11.68 17 40622 115334 64342759
Constipation 30.59 11.68 248 40391 229089 64229004
Basal ganglion degeneration 30.58 11.68 11 40628 397 64457696
Aspiration 30.55 11.68 45 40594 16840 64441253
Regurgitation 30.24 11.68 18 40621 2091 64456002
Uterine enlargement 30.06 11.68 13 40626 768 64457325
Forced vital capacity decreased 30.05 11.68 16 40623 1500 64456593
Tissue infiltration 30.01 11.68 12 40627 581 64457512
Freezing phenomenon 29.76 11.68 16 40623 1530 64456563
Impaired gastric emptying 29.63 11.68 32 40607 8772 64449321
Feeling jittery 29.57 11.68 35 40604 10600 64447493
Tinnitus 29.54 11.68 66 40573 34067 64424026
Incontinence 29.13 11.68 37 40602 12044 64446049
Cardiac failure congestive 28.75 11.68 24 40615 130556 64327537
Cataract 28.62 11.68 84 40555 51178 64406915
Secondary adrenocortical insufficiency 28.48 11.68 18 40621 2327 64455766
Stoma site pain 28.38 11.68 14 40625 1119 64456974
Maternal exposure during breast feeding 28.37 11.68 17 40622 1999 64456094
Systemic lupus erythematosus 28.32 11.68 7 40632 77605 64380488
Total lung capacity decreased 28.14 11.68 16 40623 1706 64456387
Lung diffusion test decreased 27.66 11.68 14 40625 1182 64456911
Hyperchlorhydria 27.49 11.68 16 40623 1783 64456310
Nightmare 27.11 11.68 48 40591 20945 64437148
Stoma site inflammation 26.93 11.68 11 40628 563 64457530
Gingival pain 26.61 11.68 26 40613 6341 64451752
Renal failure 26.60 11.68 46 40593 181642 64276451
Thyroid stimulating immunoglobulin increased 26.39 11.68 7 40632 88 64458005
Nail dystrophy 26.36 11.68 12 40627 801 64457292
Abdominal tenderness 26.23 11.68 31 40608 9374 64448719
Folate deficiency 25.79 11.68 18 40621 2745 64455348
Oral cavity fistula 25.19 11.68 11 40628 665 64457428
Chronic sinusitis 25.01 11.68 25 40614 6267 64451826
Hepatic enzyme increased 24.96 11.68 27 40612 129916 64328177
Rhinalgia 24.86 11.68 13 40626 1175 64456918
Gastrooesophageal reflux disease 24.78 11.68 111 40528 83032 64375061
Hyperkinesia 24.74 11.68 17 40622 2529 64455564
Tremor 24.69 11.68 169 40470 148061 64310032
Neuropathy peripheral 24.56 11.68 142 40497 117383 64340710
Stoma site infection 24.39 11.68 13 40626 1222 64456871
Akinesia 24.04 11.68 18 40621 3061 64455032
Subileus 24.00 11.68 22 40617 4955 64453138
Restlessness 23.96 11.68 67 40572 39718 64418375
Impulse-control disorder 23.94 11.68 14 40625 1574 64456519
Inguinal hernia 23.72 11.68 23 40616 5558 64452535
Bronchopulmonary aspergillosis allergic 23.67 11.68 14 40625 1608 64456485
Lower respiratory tract infection 23.61 11.68 120 40519 94494 64363599
Stoma site hypergranulation 23.52 11.68 9 40630 387 64457706
Anaesthesia 23.03 11.68 9 40630 410 64457683
Hypokalaemia 22.74 11.68 143 40496 121760 64336333
Biliary sepsis 22.62 11.68 13 40626 1415 64456678
Blood sodium decreased 22.22 11.68 54 40585 29428 64428665
Mania 22.02 11.68 38 40601 16248 64441845
Sleep disorder 21.93 11.68 85 40554 59624 64398469
Intentional medical device removal by patient 21.90 11.68 8 40631 302 64457791
Serotonin syndrome 21.57 11.68 64 40575 39218 64418875
Joint swelling 21.48 11.68 67 40572 215315 64242778
Contraindicated product administered 21.16 11.68 22 40617 107807 64350286
Rash 21.14 11.68 186 40453 458363 63999730
Respiratory tract malformation 21.00 11.68 5 40634 39 64458054
Body temperature fluctuation 20.81 11.68 17 40622 3281 64454812
Cyanosis 20.48 11.68 44 40595 22111 64435982
Blepharospasm 20.47 11.68 17 40622 3358 64454735
Fanconi syndrome 20.38 11.68 15 40624 2486 64455607
Dysphagia 20.36 11.68 126 40513 106686 64351407
Vascular encephalopathy 20.32 11.68 9 40630 563 64457530
Delirium 19.59 11.68 91 40548 69103 64388990
Gastric disorder 19.41 11.68 51 40588 29146 64428947
Glomerulonephritis chronic 19.14 11.68 7 40632 265 64457828
Pneumonia aspiration 19.08 11.68 81 40558 59190 64398903
Drug hypersensitivity 19.07 11.68 81 40558 237734 64220359
Dementia 18.92 11.68 41 40598 20725 64437368
Oesophageal haemorrhage 18.84 11.68 12 40627 1572 64456521
Stoma complication 18.67 11.68 8 40631 462 64457631
Treatment failure 18.57 11.68 28 40611 116788 64341305
Pallor 18.35 11.68 60 40579 38721 64419372
Taste disorder 18.32 11.68 26 40613 9407 64448686
Adrenal suppression 18.18 11.68 11 40628 1316 64456777
Axillary pain 17.86 11.68 12 40627 1720 64456373
Hypomagnesaemia 17.84 11.68 58 40581 37318 64420775
Overdose 17.84 11.68 47 40592 159519 64298574
Speech disorder 17.82 11.68 69 40570 48372 64409721
Nail bed tenderness 17.74 11.68 7 40632 327 64457766
Myocardial infarction 17.67 11.68 50 40589 165771 64292322
Coronary artery disease 17.61 11.68 8 40631 60425 64397668
Gastritis fungal 17.51 11.68 6 40633 187 64457906
Abdominal pain 17.42 11.68 285 40354 312090 64146003
Heart rate increased 17.32 11.68 114 40525 98561 64359532
Maternal exposure during pregnancy 17.24 11.68 21 40618 95863 64362230
Cardio-respiratory arrest 17.22 11.68 22 40617 98371 64359722
Psychogenic seizure 17.20 11.68 12 40627 1829 64456264
Sputum discoloured 17.13 11.68 36 40603 17820 64440273
Lung opacity 17.13 11.68 15 40624 3184 64454909
Anti-cyclic citrullinated peptide antibody positive 17.08 11.68 5 40634 49557 64408536
Oral candidiasis 16.94 11.68 42 40597 23170 64434923
Vulvovaginal pruritus 16.94 11.68 12 40627 1874 64456219
Pyrexia 16.90 11.68 466 40173 558178 63899915
Paranoia 16.90 11.68 34 40605 16318 64441775
Vitamin B12 deficiency 16.88 11.68 19 40620 5453 64452640
Injection site erythema 16.87 11.68 12 40627 70788 64387305
Infusion site vesicles 16.64 11.68 7 40632 386 64457707
Cerebrovascular accident 16.56 11.68 39 40600 137544 64320549
Diarrhoea 16.37 11.68 582 40057 722122 63735971
Illness 16.33 11.68 40 40599 21898 64436195
Terminal ileitis 16.31 11.68 8 40631 632 64457461
Drug withdrawal syndrome 16.26 11.68 50 40589 31241 64426852
Saliva altered 16.18 11.68 7 40632 414 64457679
Monoplegia 16.18 11.68 15 40624 3428 64454665
Pyelonephritis acute 16.13 11.68 18 40621 5116 64452977
Lower respiratory tract infection viral 15.95 11.68 9 40630 946 64457147
Neuroleptic malignant syndrome 15.95 11.68 43 40596 24953 64433140
Limbic encephalitis 15.95 11.68 8 40631 663 64457430
Abdominal discomfort 15.94 11.68 60 40579 182262 64275831
Eye pain 15.94 11.68 50 40589 31575 64426518
Hand deformity 15.81 11.68 10 40629 62761 64395332
Device kink 15.73 11.68 11 40628 1682 64456411
Pericarditis 15.69 11.68 10 40629 62506 64395587
Bradykinesia 15.67 11.68 20 40619 6540 64451553
Urinary retention 15.65 11.68 67 40572 49134 64408959
Suicidal ideation 15.63 11.68 83 40556 66459 64391634
Oropharyngeal discomfort 15.57 11.68 18 40621 5317 64452776
Torsade de pointes 15.50 11.68 34 40605 17329 64440764
Discomfort 15.31 11.68 17 40622 80861 64377232
Bezoar 15.27 11.68 12 40627 2191 64455902
Anti-thyroid antibody positive 15.27 11.68 7 40632 475 64457618
Hypersensitivity 15.09 11.68 68 40571 196384 64261709
Stoma site extravasation 14.96 11.68 6 40633 293 64457800
Adverse drug reaction 14.93 11.68 5 40634 45459 64412634
Repetitive strain injury 14.91 11.68 5 40634 146 64457947
Febrile neutropenia 14.79 11.68 182 40457 187475 64270618
Infertility 14.74 11.68 7 40632 515 64457578
Oesophagitis 14.60 11.68 38 40601 21592 64436501
Limb injury 14.56 11.68 40 40599 23465 64434628
Hypochromic anaemia 14.51 11.68 12 40627 2356 64455737
Vision blurred 14.46 11.68 102 40537 90214 64367879
Dyskinesia oesophageal 14.43 11.68 4 40635 60 64458033
Shock symptom 14.38 11.68 5 40634 163 64457930
Poor sucking reflex 14.37 11.68 4 40635 61 64458032
Pulmonary function test decreased 14.35 11.68 19 40620 6442 64451651
Onychoclasis 14.26 11.68 16 40623 4576 64453517
Vulvovaginal burning sensation 14.19 11.68 9 40630 1170 64456923
Sequestrectomy 14.18 11.68 8 40631 841 64457252
Bronchiectasis 14.14 11.68 29 40610 14111 64443982
Exposed bone in jaw 14.13 11.68 14 40625 3473 64454620
Functional residual capacity decreased 13.85 11.68 4 40635 70 64458023
Psoriatic arthropathy 13.80 11.68 5 40634 43276 64414817
Aggression 13.66 11.68 6 40633 46226 64411867
Psoriasis 13.65 11.68 15 40624 71688 64386405
Faecaloma 13.55 11.68 23 40616 9705 64448388
General physical health deterioration 13.50 11.68 192 40447 204233 64253860
Injection site pustule 13.50 11.68 4 40635 77 64458016
Dysaesthesia pharynx 13.39 11.68 5 40634 201 64457892
Mucosal inflammation 13.32 11.68 76 40563 62508 64395585
Lumbosacral plexus injury 13.29 11.68 3 40636 18 64458075
Angina pectoris 13.29 11.68 60 40579 45021 64413072
Sinus bradycardia 13.24 11.68 38 40601 22855 64435238
Lung disorder 13.10 11.68 74 40565 60626 64397467
Wrong technique in product usage process 13.04 11.68 13 40626 64961 64393132
Dyspepsia 13.03 11.68 91 40548 80221 64377872
Bone marrow failure 12.98 11.68 7 40632 47945 64410148
Obstructive airways disorder 12.94 11.68 38 40601 23147 64434946
Glossodynia 12.92 11.68 13 40626 64683 64393410
Duodenal stenosis 12.91 11.68 7 40632 681 64457412
Intestinal dilatation 12.90 11.68 11 40628 2253 64455840
Injury 12.68 11.68 10 40629 55982 64402111
Unresponsive to stimuli 12.63 11.68 64 40575 50329 64407764
Carcinoid tumour 12.62 11.68 6 40633 442 64457651
Disturbance in attention 12.35 11.68 55 40584 41019 64417074
Treatment noncompliance 12.29 11.68 6 40633 43476 64414617
Thyroxine free increased 12.22 11.68 8 40631 1099 64456994
Lacrimation increased 12.15 11.68 32 40607 18314 64439779
HER2 positive breast cancer 12.13 11.68 5 40634 262 64457831
Asthma-chronic obstructive pulmonary disease overlap syndrome 12.10 11.68 8 40631 1117 64456976
Multiple organ dysfunction syndrome 12.00 11.68 29 40610 101384 64356709
Swelling 11.98 11.68 56 40583 160162 64297931
Nausea 11.94 11.68 607 40032 785193 63672900
Gastrointestinal sounds abnormal 11.94 11.68 15 40624 4828 64453265
Emotional distress 11.77 11.68 4 40635 36034 64422059
Adrenal insufficiency 11.74 11.68 36 40603 22451 64435642
Deep vein thrombosis 11.73 11.68 31 40608 105151 64352942
Hepatocellular injury 11.72 11.68 58 40581 45177 64412916
Epilepsy 11.72 11.68 47 40592 33484 64424609
Needle issue 11.71 11.68 21 40618 9251 64448842
Paralysis recurrent laryngeal nerve 11.70 11.68 4 40635 124 64457969

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Generalised tonic-clonic seizure 31.25 20.09 6 7 98 84567

Pharmacologic Action:

SourceCodeDescription
ATC A03FA03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Acute gastric ulcer with perforation contraindication 19850005
Torsades de pointes contraindication 31722008
Acute nephropathy contraindication 58574008
Acute gastric ulcer with hemorrhage contraindication 89748001
Prolonged QT interval contraindication 111975006
Gastrointestinal obstruction contraindication 126765001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Congenital long QT syndrome contraindication 442917000
Pituitary Prolactinoma contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Horses Prevention of fescue toxicosis in periparturient mares Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Equidone Gel Dechra, Ltd. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.45 acidic
pKa2 10.04 acidic
pKa3 7.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.40 IUPHAR IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 5.99 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.79 WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.79 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.59 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 7.96 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.78 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.16 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR Ki 6.65 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 6.01 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 8.46 CHEMBL
Histamine H1 receptor GPCR Ki 6.81 DRUG MATRIX
Aldehyde oxidase Enzyme IC50 5.52 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 6.83 DRUG MATRIX
Cytochrome P450 2D6 Enzyme Ki 5.10 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.94 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 6.28 WOMBAT-PK
Kappa-type opioid receptor GPCR Ki 5.55 DRUG MATRIX
Calmodulin Cytosolic other WOMBAT-PK
Retinoic acid receptor RXR-alpha Nuclear hormone receptor Kd 5.06 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.10 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.64 CHEMBL
Mu-type opioid receptor GPCR Ki 5.77 DRUG MATRIX
Multidrug and toxin extrusion protein 2 Transporter IC50 4.83 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 7.06 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 6.55 CHEMBL
D(2) dopamine receptor GPCR Ki 9.28 CHEMBL
D(3) dopamine receptor GPCR Ki 7.93 CHEMBL

External reference:

IDSource
4025225 VUID
N0000171760 NUI
D01745 KEGG_DRUG
83898-65-1 SECONDARY_CAS_RN
203007 RXNORM
4025225 VANDF
C0013015 UMLSCUI
CHEBI:31515 CHEBI
CHEMBL219916 ChEMBL_ID
D004294 MESH_DESCRIPTOR_UI
DB01184 DRUGBANK_ID
3151 PUBCHEM_CID
965 IUPHAR_LIGAND_ID
4110 INN_ID
5587267Z69 UNII
003454 NDDF
005091 NDDF
32955006 SNOMEDCT_US
384972001 SNOMEDCT_US
387181004 SNOMEDCT_US

Pharmaceutical products:

None