Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastics, taxane derivatives | 939 | 114977-28-5 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.15 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 14 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 27, 1995 | EMA | Sanofi Mature IP | |
May 14, 1996 | FDA | SANOFI AVENTIS US |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1686.49 | 14.34 | 1390 | 91413 | 117059 | 63279160 |
Neutropenia | 1510.99 | 14.34 | 1552 | 91251 | 173453 | 63222766 |
Myelosuppression | 1492.57 | 14.34 | 717 | 92086 | 22986 | 63373233 |
Diarrhoea | 1076.24 | 14.34 | 2855 | 89948 | 712511 | 62683708 |
Palmar-plantar erythrodysaesthesia syndrome | 1041.51 | 14.34 | 557 | 92246 | 22458 | 63373761 |
Disease progression | 1031.50 | 14.34 | 1074 | 91729 | 121684 | 63274535 |
Malignant neoplasm progression | 1020.31 | 14.34 | 892 | 91911 | 81229 | 63314990 |
Ejection fraction decreased | 860.23 | 14.34 | 486 | 92317 | 21846 | 63374373 |
Mucosal inflammation | 841.77 | 14.34 | 632 | 92171 | 46296 | 63349923 |
Neuropathy peripheral | 719.33 | 14.34 | 858 | 91945 | 112809 | 63283410 |
Metastases to bone | 712.55 | 14.34 | 421 | 92382 | 20598 | 63375621 |
Metastases to liver | 627.15 | 14.34 | 405 | 92398 | 23234 | 63372985 |
Bone marrow failure | 603.29 | 14.34 | 429 | 92374 | 28861 | 63367358 |
Metastases to central nervous system | 458.58 | 14.34 | 268 | 92535 | 12837 | 63383382 |
Agranulocytosis | 427.25 | 14.34 | 328 | 92475 | 24806 | 63371413 |
Metastases to lung | 420.61 | 14.34 | 251 | 92552 | 12499 | 63383720 |
Drug ineffective | 416.57 | 14.34 | 554 | 92249 | 1044211 | 62352008 |
Metastases to lymph nodes | 404.52 | 14.34 | 210 | 92593 | 7948 | 63388271 |
Cardiotoxicity | 397.84 | 14.34 | 210 | 92593 | 8228 | 63387991 |
Rheumatoid arthritis | 349.62 | 14.34 | 4 | 92799 | 253815 | 63142404 |
Neutropenic sepsis | 343.55 | 14.34 | 243 | 92560 | 16195 | 63380024 |
Neoplasm progression | 327.46 | 14.34 | 331 | 92472 | 36097 | 63360122 |
Joint swelling | 321.54 | 14.34 | 48 | 92755 | 327618 | 63068601 |
Leukopenia | 295.28 | 14.34 | 457 | 92346 | 76833 | 63319386 |
Polyneuropathy | 294.13 | 14.34 | 211 | 92592 | 14378 | 63381841 |
Neutrophil count decreased | 272.91 | 14.34 | 373 | 92430 | 56033 | 63340186 |
Contraindicated product administered | 270.64 | 14.34 | 11 | 92792 | 217637 | 63178582 |
Systemic lupus erythematosus | 268.72 | 14.34 | 8 | 92795 | 208910 | 63187309 |
Skin toxicity | 261.78 | 14.34 | 131 | 92672 | 4583 | 63391636 |
Arthropathy | 258.59 | 14.34 | 23 | 92780 | 234769 | 63161450 |
Pleural effusion | 257.58 | 14.34 | 477 | 92326 | 92733 | 63303486 |
White blood cell count decreased | 252.35 | 14.34 | 599 | 92204 | 138505 | 63257714 |
Peripheral sensory neuropathy | 243.95 | 14.34 | 146 | 92657 | 7305 | 63388914 |
Therapeutic product effect decreased | 242.77 | 14.34 | 9 | 92794 | 193178 | 63203041 |
Breast cancer recurrent | 239.19 | 14.34 | 120 | 92683 | 4221 | 63391998 |
Product dose omission issue | 235.16 | 14.34 | 32 | 92771 | 234281 | 63161938 |
Fall | 223.29 | 14.34 | 150 | 92653 | 392184 | 63004035 |
Vomiting | 216.13 | 14.34 | 1477 | 91326 | 558140 | 62838079 |
Bone pain | 209.90 | 14.34 | 324 | 92479 | 54317 | 63341902 |
Haematotoxicity | 208.49 | 14.34 | 144 | 92659 | 9232 | 63386987 |
Acute myeloid leukaemia | 208.00 | 14.34 | 184 | 92619 | 16963 | 63379256 |
Alopecia areata | 207.94 | 14.34 | 82 | 92721 | 1603 | 63394616 |
Hand deformity | 205.40 | 14.34 | 6 | 92797 | 159451 | 63236768 |
Nausea | 205.34 | 14.34 | 2024 | 90779 | 852447 | 62543772 |
Metastasis | 205.14 | 14.34 | 115 | 92688 | 5082 | 63391137 |
Sinusitis | 205.09 | 14.34 | 41 | 92762 | 226612 | 63169607 |
Abdominal discomfort | 198.77 | 14.34 | 111 | 92692 | 320774 | 63075445 |
Aortitis | 196.60 | 14.34 | 70 | 92733 | 1017 | 63395202 |
Left ventricular dysfunction | 196.16 | 14.34 | 153 | 92650 | 11835 | 63384384 |
Nail disorder | 193.48 | 14.34 | 157 | 92646 | 12858 | 63383361 |
Completed suicide | 189.41 | 14.34 | 5 | 92798 | 145668 | 63250551 |
Maternal exposure during pregnancy | 188.57 | 14.34 | 45 | 92758 | 220017 | 63176202 |
Decreased appetite | 186.00 | 14.34 | 793 | 92010 | 250259 | 63145960 |
Condition aggravated | 185.30 | 14.34 | 189 | 92614 | 402028 | 62994191 |
Pyrexia | 185.14 | 14.34 | 1248 | 91555 | 469230 | 62926989 |
Interstitial lung disease | 181.32 | 14.34 | 325 | 92478 | 61583 | 63334636 |
Madarosis | 181.10 | 14.34 | 89 | 92714 | 2992 | 63393227 |
Drug hypersensitivity | 180.44 | 14.34 | 116 | 92687 | 310571 | 63085648 |
Hair colour changes | 179.85 | 14.34 | 89 | 92714 | 3038 | 63393181 |
Neutropenic colitis | 177.74 | 14.34 | 88 | 92715 | 3007 | 63393212 |
Colitis | 175.62 | 14.34 | 280 | 92523 | 48248 | 63347971 |
Recall phenomenon | 173.25 | 14.34 | 56 | 92747 | 594 | 63395625 |
Anaemia | 173.14 | 14.34 | 867 | 91936 | 292563 | 63103656 |
Onycholysis | 172.17 | 14.34 | 71 | 92732 | 1565 | 63394654 |
Flushing | 167.12 | 14.34 | 351 | 92452 | 74736 | 63321483 |
Metastases to skin | 164.32 | 14.34 | 69 | 92734 | 1594 | 63394625 |
Wound | 159.77 | 14.34 | 24 | 92779 | 163239 | 63232980 |
Erythema | 157.22 | 14.34 | 589 | 92214 | 175162 | 63221057 |
Musculoskeletal stiffness | 155.71 | 14.34 | 39 | 92764 | 184579 | 63211640 |
Stomatitis | 154.51 | 14.34 | 500 | 92303 | 138225 | 63257994 |
Glossodynia | 152.39 | 14.34 | 37 | 92766 | 178839 | 63217380 |
Hair texture abnormal | 151.65 | 14.34 | 88 | 92715 | 4155 | 63392064 |
Second primary malignancy | 148.88 | 14.34 | 110 | 92693 | 7843 | 63388376 |
Treatment failure | 148 | 14.34 | 53 | 92750 | 198990 | 63197229 |
Confusional state | 145.95 | 14.34 | 82 | 92721 | 236298 | 63159921 |
Weight increased | 142.53 | 14.34 | 104 | 92699 | 260688 | 63135531 |
Product use issue | 141.26 | 14.34 | 73 | 92730 | 220447 | 63175772 |
Metastases to pleura | 140.85 | 14.34 | 61 | 92742 | 1524 | 63394695 |
Breast cancer metastatic | 137.92 | 14.34 | 125 | 92678 | 11893 | 63384326 |
Pain | 137.01 | 14.34 | 588 | 92215 | 740040 | 62656179 |
Injection site pain | 134.33 | 14.34 | 16 | 92787 | 129784 | 63266435 |
Lymphoedema | 132.98 | 14.34 | 121 | 92682 | 11571 | 63384648 |
Neurotoxicity | 130.50 | 14.34 | 142 | 92661 | 16848 | 63379371 |
Skin exfoliation | 127.11 | 14.34 | 227 | 92576 | 42875 | 63353344 |
Gastrointestinal toxicity | 127.09 | 14.34 | 99 | 92704 | 7642 | 63388577 |
Nail toxicity | 126.32 | 14.34 | 38 | 92765 | 311 | 63395908 |
Neutropenic infection | 126.04 | 14.34 | 54 | 92749 | 1313 | 63394906 |
Swelling | 126.00 | 14.34 | 130 | 92673 | 275248 | 63120971 |
Thrombocytopenia | 124.02 | 14.34 | 493 | 92310 | 150664 | 63245555 |
Epistaxis | 122.99 | 14.34 | 305 | 92498 | 72420 | 63323799 |
Hepatic enzyme increased | 122.29 | 14.34 | 72 | 92731 | 202256 | 63193963 |
Helicobacter infection | 121.29 | 14.34 | 3 | 92800 | 92782 | 63303437 |
Lacrimation increased | 119.27 | 14.34 | 149 | 92654 | 20482 | 63375737 |
Somnolence | 119.18 | 14.34 | 56 | 92747 | 178629 | 63217590 |
Dysgeusia | 114.13 | 14.34 | 227 | 92576 | 46483 | 63349736 |
Capillary leak syndrome | 107.24 | 14.34 | 56 | 92747 | 2144 | 63394075 |
Biopsy lung abnormal | 105.88 | 14.34 | 28 | 92775 | 134 | 63396085 |
Pericarditis | 104.89 | 14.34 | 31 | 92772 | 131548 | 63264671 |
Contusion | 103.21 | 14.34 | 45 | 92758 | 149999 | 63246220 |
Exposure during pregnancy | 101.81 | 14.34 | 50 | 92753 | 155497 | 63240722 |
Organising pneumonia | 101.68 | 14.34 | 77 | 92726 | 5699 | 63390520 |
Overdose | 99.56 | 14.34 | 23 | 92780 | 115055 | 63281164 |
Hypokalaemia | 99.56 | 14.34 | 356 | 92447 | 103448 | 63292771 |
Paronychia | 97.55 | 14.34 | 74 | 92729 | 5491 | 63390728 |
Duodenal ulcer perforation | 97.40 | 14.34 | 8 | 92795 | 87201 | 63309018 |
Dehydration | 96.99 | 14.34 | 505 | 92298 | 172849 | 63223370 |
Pneumonitis | 96.88 | 14.34 | 180 | 92623 | 35042 | 63361177 |
Vascular device infection | 95.80 | 14.34 | 82 | 92721 | 7230 | 63388989 |
Drug intolerance | 95.50 | 14.34 | 192 | 92611 | 308469 | 63087750 |
Drug abuse | 92.36 | 14.34 | 3 | 92800 | 72515 | 63323704 |
Dermatitis acneiform | 91.05 | 14.34 | 68 | 92735 | 4928 | 63391291 |
Myalgia | 90.51 | 14.34 | 439 | 92364 | 146090 | 63250129 |
Injury | 89.98 | 14.34 | 4 | 92799 | 73243 | 63322976 |
Osteoarthritis | 88.82 | 14.34 | 16 | 92787 | 95327 | 63300892 |
Arthritis | 87.61 | 14.34 | 30 | 92773 | 115891 | 63280328 |
Blood cholesterol increased | 87.12 | 14.34 | 16 | 92787 | 94016 | 63302203 |
Discomfort | 85.98 | 14.34 | 71 | 92732 | 167303 | 63228916 |
Headache | 85.95 | 14.34 | 558 | 92245 | 632683 | 62763536 |
Lymphangiosis carcinomatosa | 85.70 | 14.34 | 42 | 92761 | 1403 | 63394816 |
Mobility decreased | 83.85 | 14.34 | 36 | 92767 | 121123 | 63275096 |
Disease recurrence | 83.11 | 14.34 | 148 | 92655 | 27882 | 63368337 |
Nail dystrophy | 82.53 | 14.34 | 37 | 92766 | 1006 | 63395213 |
Hospitalisation | 82.07 | 14.34 | 13 | 92790 | 85068 | 63311151 |
Metastases to spine | 82.04 | 14.34 | 54 | 92749 | 3195 | 63393024 |
Hepatic function abnormal | 81.86 | 14.34 | 173 | 92630 | 36969 | 63359250 |
Dermatitis | 81.74 | 14.34 | 112 | 92691 | 16846 | 63379373 |
Irritable bowel syndrome | 80.85 | 14.34 | 12 | 92791 | 82400 | 63313819 |
Radiation skin injury | 79.59 | 14.34 | 35 | 92768 | 908 | 63395311 |
Loss of personal independence in daily activities | 79.23 | 14.34 | 22 | 92781 | 97268 | 63298951 |
Myositis | 79.23 | 14.34 | 82 | 92721 | 9184 | 63387035 |
Metastases to peritoneum | 79.20 | 14.34 | 54 | 92749 | 3388 | 63392831 |
Cardiomyopathy | 78.60 | 14.34 | 112 | 92691 | 17472 | 63378747 |
Ascites | 77.66 | 14.34 | 179 | 92624 | 40549 | 63355670 |
Acute promyelocytic leukaemia | 76.93 | 14.34 | 34 | 92769 | 893 | 63395326 |
Nail discolouration | 75.07 | 14.34 | 48 | 92755 | 2702 | 63393517 |
Inappropriate schedule of product administration | 75.01 | 14.34 | 29 | 92774 | 103936 | 63292283 |
Adverse drug reaction | 72.91 | 14.34 | 14 | 92789 | 79700 | 63316519 |
Asthenia | 72.52 | 14.34 | 868 | 91935 | 382736 | 63013483 |
Injection site erythema | 71.19 | 14.34 | 17 | 92786 | 83157 | 63313062 |
Intentional product use issue | 71.10 | 14.34 | 50 | 92753 | 127842 | 63268377 |
Large intestine perforation | 70.62 | 14.34 | 74 | 92729 | 8408 | 63387811 |
Bronchial polyp | 70.47 | 14.34 | 18 | 92785 | 73 | 63396146 |
Multifocal micronodular pneumocyte hyperplasia | 70.47 | 14.34 | 18 | 92785 | 73 | 63396146 |
Febrile bone marrow aplasia | 70.29 | 14.34 | 69 | 92734 | 7256 | 63388963 |
Hepatitis B reactivation | 69.32 | 14.34 | 48 | 92755 | 3089 | 63393130 |
Device related thrombosis | 69.09 | 14.34 | 39 | 92764 | 1746 | 63394473 |
Congestive cardiomyopathy | 66.46 | 14.34 | 62 | 92741 | 6120 | 63390099 |
Erysipelas | 65.88 | 14.34 | 69 | 92734 | 7836 | 63388383 |
Migraine | 64.95 | 14.34 | 35 | 92768 | 103311 | 63292908 |
Gastrointestinal necrosis | 64.63 | 14.34 | 44 | 92759 | 2754 | 63393465 |
Impaired healing | 64.05 | 14.34 | 35 | 92768 | 102507 | 63293712 |
Myocardial infarction | 64.01 | 14.34 | 33 | 92770 | 99860 | 63296359 |
Feeling abnormal | 63.44 | 14.34 | 74 | 92729 | 148318 | 63247901 |
Therapy partial responder | 63.24 | 14.34 | 78 | 92725 | 10580 | 63385639 |
Suicide attempt | 61.80 | 14.34 | 8 | 92795 | 60910 | 63335309 |
Depression | 61.77 | 14.34 | 121 | 92682 | 196371 | 63199848 |
Type 2 diabetes mellitus | 61.06 | 14.34 | 10 | 92793 | 63858 | 63332361 |
Metastases to meninges | 60.30 | 14.34 | 41 | 92762 | 2561 | 63393658 |
Cerebrovascular accident | 59.04 | 14.34 | 43 | 92760 | 107981 | 63288238 |
Pseudocirrhosis | 58.89 | 14.34 | 26 | 92777 | 681 | 63395538 |
Psoriasis | 58.33 | 14.34 | 27 | 92776 | 86930 | 63309289 |
Incorrect dose administered | 58.20 | 14.34 | 9 | 92794 | 59959 | 63336260 |
Osteonecrosis of jaw | 57.98 | 14.34 | 146 | 92657 | 34977 | 63361242 |
Chest discomfort | 57.79 | 14.34 | 315 | 92488 | 109654 | 63286565 |
Hot flush | 57.42 | 14.34 | 185 | 92618 | 50974 | 63345245 |
Blood lactate dehydrogenase increased | 57.24 | 14.34 | 113 | 92690 | 23003 | 63373216 |
Arthralgia | 57.15 | 14.34 | 545 | 92258 | 569165 | 62827054 |
Injection site swelling | 57.13 | 14.34 | 3 | 92800 | 47569 | 63348650 |
Dermatomyositis | 56.95 | 14.34 | 41 | 92762 | 2807 | 63393412 |
COVID-19 | 56.81 | 14.34 | 49 | 92754 | 113054 | 63283165 |
Metastases to chest wall | 56.57 | 14.34 | 24 | 92779 | 569 | 63395650 |
Injection site reaction | 56.31 | 14.34 | 9 | 92794 | 58515 | 63337704 |
Mucosal infection | 56.28 | 14.34 | 18 | 92785 | 184 | 63396035 |
Asthma | 56.28 | 14.34 | 62 | 92741 | 127499 | 63268720 |
Illness | 56.19 | 14.34 | 4 | 92799 | 49055 | 63347164 |
Granulocyte count decreased | 56.01 | 14.34 | 30 | 92773 | 1210 | 63395009 |
Device related infection | 55.11 | 14.34 | 112 | 92691 | 23280 | 63372939 |
Constipation | 54.97 | 14.34 | 536 | 92267 | 224407 | 63171812 |
Cardiac failure | 54.95 | 14.34 | 267 | 92536 | 88875 | 63307344 |
Blood pressure systolic increased | 53.90 | 14.34 | 4 | 92799 | 47393 | 63348826 |
Nasopharyngitis | 53.68 | 14.34 | 191 | 92612 | 254066 | 63142153 |
Dyspnoea | 53.02 | 14.34 | 1302 | 91501 | 660011 | 62736208 |
Enterocolitis infectious | 53.01 | 14.34 | 32 | 92771 | 1626 | 63394593 |
Alopecia totalis | 52.39 | 14.34 | 20 | 92783 | 357 | 63395862 |
Hyperfibrinogenaemia | 51.95 | 14.34 | 12 | 92791 | 28 | 63396191 |
Systemic scleroderma | 50.78 | 14.34 | 26 | 92777 | 955 | 63395264 |
Injection site pruritus | 50.76 | 14.34 | 4 | 92799 | 45112 | 63351107 |
Ventricular hypokinesia | 50.74 | 14.34 | 47 | 92756 | 4597 | 63391622 |
Performance status decreased | 49.72 | 14.34 | 42 | 92761 | 3636 | 63392583 |
Odynophagia | 49.69 | 14.34 | 58 | 92745 | 7428 | 63388791 |
Lumbosacral radiculoplexus neuropathy | 49.46 | 14.34 | 11 | 92792 | 20 | 63396199 |
Back pain | 48.22 | 14.34 | 594 | 92209 | 263551 | 63132668 |
Sepsis | 47.78 | 14.34 | 385 | 92418 | 152738 | 63243481 |
Enterocolitis | 47.42 | 14.34 | 58 | 92745 | 7800 | 63388419 |
Death | 46.87 | 14.34 | 788 | 92015 | 373593 | 63022626 |
Adverse event | 46.85 | 14.34 | 20 | 92783 | 67539 | 63328680 |
Tonsillar disorder | 46.83 | 14.34 | 26 | 92777 | 1127 | 63395092 |
Cellulitis | 46.63 | 14.34 | 240 | 92563 | 81718 | 63314501 |
Pericardial effusion | 46.57 | 14.34 | 122 | 92681 | 29936 | 63366283 |
Drug interaction | 46.47 | 14.34 | 175 | 92628 | 228956 | 63167263 |
Nasal congestion | 46.24 | 14.34 | 19 | 92784 | 65641 | 63330578 |
Drug resistance | 46.17 | 14.34 | 103 | 92700 | 22830 | 63373389 |
Wheezing | 46.11 | 14.34 | 43 | 92760 | 95552 | 63300667 |
Metastatic neoplasm | 46.02 | 14.34 | 43 | 92760 | 4252 | 63391967 |
Cardiac dysfunction | 45.55 | 14.34 | 33 | 92770 | 2282 | 63393937 |
Breast pain | 45.29 | 14.34 | 60 | 92743 | 8738 | 63387481 |
Gait inability | 44.97 | 14.34 | 11 | 92792 | 52948 | 63343271 |
Sedation | 44.92 | 14.34 | 3 | 92800 | 38806 | 63357413 |
Acute leukaemia | 44.50 | 14.34 | 25 | 92778 | 1109 | 63395110 |
Cystoid macular oedema | 44.26 | 14.34 | 28 | 92775 | 1547 | 63394672 |
Medication error | 44.13 | 14.34 | 11 | 92792 | 52273 | 63343946 |
Ear infection | 44.10 | 14.34 | 3 | 92800 | 38210 | 63358009 |
Metastases to the mediastinum | 44.08 | 14.34 | 19 | 92784 | 469 | 63395750 |
Myelodysplastic syndrome | 44.04 | 14.34 | 84 | 92719 | 16670 | 63379549 |
Blood creatinine decreased | 43.72 | 14.34 | 47 | 92756 | 5498 | 63390721 |
Periarticular thenar erythema with onycholysis | 43.59 | 14.34 | 11 | 92792 | 42 | 63396177 |
Onychalgia | 42.48 | 14.34 | 23 | 92780 | 948 | 63395271 |
Bursitis | 42.48 | 14.34 | 3 | 92800 | 37038 | 63359181 |
Suicidal ideation | 42.46 | 14.34 | 19 | 92784 | 62402 | 63333817 |
Road traffic accident | 41.91 | 14.34 | 3 | 92800 | 36629 | 63359590 |
Mastitis | 41.77 | 14.34 | 33 | 92770 | 2599 | 63393620 |
Excessive eye blinking | 41.68 | 14.34 | 25 | 92778 | 1255 | 63394964 |
Blood uric acid decreased | 40.80 | 14.34 | 21 | 92782 | 780 | 63395439 |
Dacryostenosis acquired | 40.05 | 14.34 | 19 | 92784 | 590 | 63395629 |
Onychomadesis | 40.02 | 14.34 | 46 | 92757 | 5794 | 63390425 |
Hallucination | 40.02 | 14.34 | 15 | 92788 | 54802 | 63341417 |
Invasive ductal breast carcinoma | 39.81 | 14.34 | 50 | 92753 | 6908 | 63389311 |
Hypocalcaemia | 39.58 | 14.34 | 119 | 92684 | 31594 | 63364625 |
Pregnancy | 39.46 | 14.34 | 4 | 92799 | 36832 | 63359387 |
Nephrolithiasis | 39.19 | 14.34 | 7 | 92796 | 41977 | 63354242 |
Metastases to adrenals | 38.80 | 14.34 | 20 | 92783 | 745 | 63395474 |
Influenza | 38.61 | 14.34 | 62 | 92741 | 108660 | 63287559 |
Folliculitis | 38.40 | 14.34 | 28 | 92775 | 70289 | 63325930 |
Plasma cell myeloma | 38.20 | 14.34 | 4 | 92799 | 35901 | 63360318 |
Anxiety | 37.99 | 14.34 | 176 | 92627 | 217365 | 63178854 |
Bone marrow infiltration | 37.95 | 14.34 | 19 | 92784 | 665 | 63395554 |
Cataract | 37.82 | 14.34 | 18 | 92785 | 57035 | 63339184 |
Bradycardia | 37.65 | 14.34 | 31 | 92772 | 73196 | 63323023 |
Alanine aminotransferase increased | 37.45 | 14.34 | 270 | 92533 | 103500 | 63292719 |
Radiation necrosis | 37.38 | 14.34 | 16 | 92787 | 388 | 63395831 |
Pulmonary mass | 37.37 | 14.34 | 94 | 92709 | 22502 | 63373717 |
Peripheral swelling | 37.12 | 14.34 | 232 | 92571 | 265710 | 63130509 |
Computerised tomogram thorax abnormal | 36.68 | 14.34 | 26 | 92777 | 1737 | 63394482 |
Fatigue | 36.43 | 14.34 | 1615 | 91188 | 886413 | 62509806 |
Cystitis noninfective | 36.37 | 14.34 | 21 | 92782 | 982 | 63395237 |
Electrocardiogram QT prolonged | 36.19 | 14.34 | 21 | 92782 | 59509 | 63336710 |
Therapy interrupted | 36.17 | 14.34 | 3 | 92800 | 32452 | 63363767 |
Mastectomy | 36.11 | 14.34 | 25 | 92778 | 1608 | 63394611 |
Eosinophil percentage increased | 35.87 | 14.34 | 21 | 92782 | 1008 | 63395211 |
Carotidynia | 35.86 | 14.34 | 12 | 92791 | 143 | 63396076 |
Bronchitis | 35.83 | 14.34 | 81 | 92722 | 124854 | 63271365 |
Gait disturbance | 35.78 | 14.34 | 142 | 92661 | 183036 | 63213183 |
Malignant pleural effusion | 35.73 | 14.34 | 30 | 92773 | 2576 | 63393643 |
Gastric disorder | 35.38 | 14.34 | 6 | 92797 | 37363 | 63358856 |
HER2 positive breast cancer | 35.15 | 14.34 | 15 | 92788 | 361 | 63395858 |
Blood alkaline phosphatase increased | 35.06 | 14.34 | 140 | 92663 | 42827 | 63353392 |
Obstructive shock | 34.57 | 14.34 | 9 | 92794 | 40 | 63396179 |
Acute interstitial pneumonitis | 34.54 | 14.34 | 18 | 92785 | 686 | 63395533 |
Nail infection | 34.50 | 14.34 | 29 | 92774 | 2494 | 63393725 |
Hyperpyrexia | 34.45 | 14.34 | 34 | 92769 | 3598 | 63392621 |
Abortion spontaneous | 34.31 | 14.34 | 13 | 92790 | 47182 | 63349037 |
Swollen tongue | 34.28 | 14.34 | 5 | 92798 | 34795 | 63361424 |
Intestinal perforation | 33.97 | 14.34 | 62 | 92741 | 11901 | 63384318 |
Red blood cell sedimentation rate increased | 33.88 | 14.34 | 11 | 92792 | 43971 | 63352248 |
Gamma-glutamyltransferase increased | 33.70 | 14.34 | 118 | 92685 | 33913 | 63362306 |
Gas gangrene | 33.67 | 14.34 | 11 | 92792 | 121 | 63396098 |
Troponin I increased | 33.26 | 14.34 | 27 | 92776 | 2211 | 63394008 |
Osteolysis | 33.18 | 14.34 | 30 | 92773 | 2844 | 63393375 |
Folate deficiency | 32.92 | 14.34 | 28 | 92775 | 2447 | 63393772 |
Hypertension | 32.90 | 14.34 | 256 | 92547 | 279047 | 63117172 |
Urticaria | 32.71 | 14.34 | 128 | 92675 | 165674 | 63230545 |
Tumour embolism | 32.66 | 14.34 | 11 | 92792 | 134 | 63396085 |
Intestinal ischaemia | 32.54 | 14.34 | 47 | 92756 | 7421 | 63388798 |
Nephritis bacterial | 32.47 | 14.34 | 8 | 92795 | 27 | 63396192 |
EGFR gene mutation | 31.63 | 14.34 | 13 | 92790 | 284 | 63395935 |
Pruritus | 31.55 | 14.34 | 357 | 92446 | 361096 | 63035123 |
Platelet count decreased | 31.48 | 14.34 | 283 | 92520 | 115839 | 63280380 |
Unevaluable event | 31.41 | 14.34 | 18 | 92785 | 51368 | 63344851 |
Hepatic lesion | 31.39 | 14.34 | 37 | 92766 | 4788 | 63391431 |
Osteoporosis | 31.09 | 14.34 | 23 | 92780 | 57315 | 63338904 |
Foetal exposure during pregnancy | 30.56 | 14.34 | 5 | 92798 | 31957 | 63364262 |
Blister | 30.48 | 14.34 | 93 | 92710 | 129721 | 63266498 |
Malaise | 30.28 | 14.34 | 427 | 92376 | 415527 | 62980692 |
Basal cell carcinoma | 30.08 | 14.34 | 3 | 92800 | 27988 | 63368231 |
Dysuria | 30.03 | 14.34 | 113 | 92690 | 33625 | 63362594 |
Scleroderma renal crisis | 29.93 | 14.34 | 13 | 92790 | 327 | 63395892 |
Breast inflammation | 29.92 | 14.34 | 11 | 92792 | 176 | 63396043 |
Barotrauma | 29.86 | 14.34 | 11 | 92792 | 177 | 63396042 |
Biliary sepsis | 29.84 | 14.34 | 18 | 92785 | 913 | 63395306 |
Systolic dysfunction | 29.67 | 14.34 | 22 | 92781 | 1577 | 63394642 |
Toxic optic neuropathy | 29.47 | 14.34 | 11 | 92792 | 184 | 63396035 |
Abdominal pain | 29.13 | 14.34 | 596 | 92207 | 292860 | 63103359 |
Vulvovaginal candidiasis | 28.78 | 14.34 | 29 | 92774 | 3146 | 63393073 |
Lactic acidosis | 28.76 | 14.34 | 10 | 92793 | 38277 | 63357942 |
Vascular fragility | 28.75 | 14.34 | 10 | 92793 | 135 | 63396084 |
Coma | 28.69 | 14.34 | 31 | 92772 | 64333 | 63331886 |
Autonomic neuropathy | 28.62 | 14.34 | 19 | 92784 | 1140 | 63395079 |
Therapy cessation | 28.60 | 14.34 | 5 | 92798 | 30452 | 63365767 |
Blood glucose increased | 28.59 | 14.34 | 49 | 92754 | 83707 | 63312512 |
Perforation | 28.27 | 14.34 | 19 | 92784 | 1164 | 63395055 |
Left ventricular dilatation | 28.04 | 14.34 | 14 | 92789 | 487 | 63395732 |
Lymphadenopathy | 28.00 | 14.34 | 121 | 92682 | 38337 | 63357882 |
Tongue coated | 27.97 | 14.34 | 20 | 92783 | 1355 | 63394864 |
Hypertransaminasaemia | 27.93 | 14.34 | 41 | 92762 | 6568 | 63389651 |
Invasive lobular breast carcinoma | 27.91 | 14.34 | 17 | 92786 | 878 | 63395341 |
Palmar erythema | 27.71 | 14.34 | 22 | 92781 | 1745 | 63394474 |
Treatment noncompliance | 27.60 | 14.34 | 10 | 92793 | 37315 | 63358904 |
Ejection fraction | 27.55 | 14.34 | 25 | 92778 | 2381 | 63393838 |
Intentional product misuse | 27.53 | 14.34 | 29 | 92774 | 60888 | 63335331 |
Nasal disorder | 27.52 | 14.34 | 27 | 92776 | 2837 | 63393382 |
Joint injury | 27.45 | 14.34 | 5 | 92798 | 29567 | 63366652 |
International normalised ratio increased | 27.34 | 14.34 | 17 | 92786 | 46408 | 63349811 |
Paraesthesia | 27.32 | 14.34 | 350 | 92453 | 156616 | 63239603 |
Eastern Cooperative Oncology Group performance status worsened | 27.27 | 14.34 | 19 | 92784 | 1235 | 63394984 |
Vulvovaginal dryness | 27.23 | 14.34 | 27 | 92776 | 2874 | 63393345 |
Vein discolouration | 27.16 | 14.34 | 11 | 92792 | 231 | 63395988 |
Coronary artery disease | 26.96 | 14.34 | 7 | 92796 | 32370 | 63363849 |
Hyperchlorhydria | 26.89 | 14.34 | 22 | 92781 | 1822 | 63394397 |
Onychoclasis | 26.88 | 14.34 | 39 | 92764 | 6183 | 63390036 |
Dizziness | 26.66 | 14.34 | 455 | 92348 | 429470 | 62966749 |
Hepatotoxicity | 26.55 | 14.34 | 116 | 92687 | 36925 | 63359294 |
Dyskinesia | 26.49 | 14.34 | 7 | 92796 | 31995 | 63364224 |
Vessel puncture site bruise | 26.45 | 14.34 | 13 | 92790 | 437 | 63395782 |
Subclavian vein thrombosis | 26.41 | 14.34 | 22 | 92781 | 1868 | 63394351 |
Breast cancer | 26.35 | 14.34 | 140 | 92663 | 48243 | 63347976 |
Asthenopia | 26.21 | 14.34 | 24 | 92779 | 2313 | 63393906 |
Metastases to soft tissue | 26.17 | 14.34 | 10 | 92793 | 179 | 63396040 |
Full blood count abnormal | 26.14 | 14.34 | 7 | 92796 | 31710 | 63364509 |
Balance disorder | 25.64 | 14.34 | 53 | 92750 | 84369 | 63311850 |
Axillary pain | 25.49 | 14.34 | 22 | 92781 | 1961 | 63394258 |
Aspartate aminotransferase increased | 25.48 | 14.34 | 222 | 92581 | 90055 | 63306164 |
Clostridium bacteraemia | 25.33 | 14.34 | 10 | 92793 | 196 | 63396023 |
Alopecia | 25.27 | 14.34 | 659 | 92144 | 336877 | 63059342 |
Foot deformity | 25.24 | 14.34 | 5 | 92798 | 27848 | 63368371 |
Nervousness | 25.22 | 14.34 | 7 | 92796 | 30972 | 63365247 |
Hiccups | 25.19 | 14.34 | 23 | 92780 | 2208 | 63394011 |
Granulocytopenia | 25.16 | 14.34 | 36 | 92767 | 5636 | 63390583 |
Injection site haemorrhage | 25.13 | 14.34 | 3 | 92800 | 24311 | 63371908 |
Pancreatitis | 24.93 | 14.34 | 21 | 92782 | 49034 | 63347185 |
Vascular pain | 24.72 | 14.34 | 15 | 92788 | 769 | 63395450 |
Retinal toxicity | 24.69 | 14.34 | 18 | 92785 | 1257 | 63394962 |
Blood pressure fluctuation | 24.57 | 14.34 | 19 | 92784 | 46298 | 63349921 |
Pneumocystis jirovecii pneumonia | 24.53 | 14.34 | 67 | 92736 | 16847 | 63379372 |
Toxicity to various agents | 24.49 | 14.34 | 237 | 92566 | 247013 | 63149206 |
Acoustic stimulation tests abnormal | 24.49 | 14.34 | 8 | 92795 | 88 | 63396131 |
Oral candidiasis | 24.28 | 14.34 | 81 | 92722 | 22717 | 63373502 |
Menopausal disorder | 24.22 | 14.34 | 7 | 92796 | 49 | 63396170 |
Pneumonia salmonella | 24.19 | 14.34 | 5 | 92798 | 5 | 63396214 |
Mouth ulceration | 24.18 | 14.34 | 104 | 92699 | 32880 | 63363339 |
Leukocytosis | 24.03 | 14.34 | 88 | 92715 | 25847 | 63370372 |
Acquired gene mutation | 24 | 14.34 | 16 | 92787 | 967 | 63395252 |
Extravasation | 23.99 | 14.34 | 23 | 92780 | 2349 | 63393870 |
Nail bed bleeding | 23.98 | 14.34 | 11 | 92792 | 316 | 63395903 |
Septic shock | 23.82 | 14.34 | 173 | 92630 | 66456 | 63329763 |
Accidental overdose | 23.79 | 14.34 | 3 | 92800 | 23306 | 63372913 |
Prescribed underdose | 23.63 | 14.34 | 7 | 92796 | 29682 | 63366537 |
Metastases to thorax | 23.61 | 14.34 | 10 | 92793 | 236 | 63395983 |
Ovarian necrosis | 23.56 | 14.34 | 6 | 92797 | 24 | 63396195 |
Cough | 23.51 | 14.34 | 577 | 92226 | 292166 | 63104053 |
Recurrent cancer | 23.45 | 14.34 | 21 | 92782 | 1966 | 63394253 |
Frequent bowel movements | 23.40 | 14.34 | 3 | 92800 | 23019 | 63373200 |
Depressed level of consciousness | 23.38 | 14.34 | 34 | 92769 | 62044 | 63334175 |
Panophthalmitis | 23.35 | 14.34 | 8 | 92795 | 103 | 63396116 |
Cannabinoid hyperemesis syndrome | 23.30 | 14.34 | 7 | 92796 | 57 | 63396162 |
Generalised oedema | 23.28 | 14.34 | 63 | 92740 | 15755 | 63380464 |
Adenocarcinoma | 23.25 | 14.34 | 25 | 92778 | 2925 | 63393294 |
Metastases to bone marrow | 23.21 | 14.34 | 12 | 92791 | 450 | 63395769 |
Thrombotic microangiopathy | 23.04 | 14.34 | 49 | 92754 | 10512 | 63385707 |
Peritonitis | 22.96 | 14.34 | 66 | 92737 | 17088 | 63379131 |
PIK3CA-activated mutation | 22.92 | 14.34 | 16 | 92787 | 1043 | 63395176 |
Meibomian gland dysfunction | 22.91 | 14.34 | 9 | 92794 | 174 | 63396045 |
Multiple sclerosis | 22.88 | 14.34 | 4 | 92799 | 24368 | 63371851 |
Choroidal effusion | 22.87 | 14.34 | 12 | 92791 | 464 | 63395755 |
Hepatic failure | 22.83 | 14.34 | 108 | 92695 | 35548 | 63360671 |
Portal hypertension | 22.74 | 14.34 | 28 | 92775 | 3791 | 63392428 |
Salmonella sepsis | 22.68 | 14.34 | 10 | 92793 | 261 | 63395958 |
Joint neoplasm | 22.68 | 14.34 | 7 | 92796 | 63 | 63396156 |
Overflow diarrhoea | 22.61 | 14.34 | 8 | 92795 | 114 | 63396105 |
Embolism | 22.48 | 14.34 | 41 | 92762 | 7865 | 63388354 |
Tremor | 22.47 | 14.34 | 108 | 92695 | 132131 | 63264088 |
Grip strength decreased | 22.43 | 14.34 | 3 | 92800 | 22284 | 63373935 |
Hydrothorax | 22.36 | 14.34 | 15 | 92788 | 916 | 63395303 |
Neck pain | 22.36 | 14.34 | 42 | 92761 | 69276 | 63326943 |
Osteitis condensans | 22.31 | 14.34 | 6 | 92797 | 31 | 63396188 |
Foot fracture | 22.29 | 14.34 | 4 | 92799 | 23910 | 63372309 |
Agitation | 22.24 | 14.34 | 33 | 92770 | 59724 | 63336495 |
Pneumothorax | 22.19 | 14.34 | 63 | 92740 | 16198 | 63380021 |
Lipoprotein increased | 22.17 | 14.34 | 5 | 92798 | 10 | 63396209 |
Inflammatory carcinoma of the breast | 22.03 | 14.34 | 7 | 92796 | 70 | 63396149 |
Pleural disorder | 22.02 | 14.34 | 13 | 92790 | 634 | 63395585 |
Chronic obstructive pulmonary disease | 22.01 | 14.34 | 36 | 92767 | 62650 | 63333569 |
Oral pain | 21.96 | 14.34 | 91 | 92712 | 28303 | 63367916 |
Therapeutic product effect incomplete | 21.91 | 14.34 | 101 | 92702 | 124955 | 63271264 |
Insomnia | 21.88 | 14.34 | 205 | 92598 | 215047 | 63181172 |
Soft tissue neoplasm | 21.85 | 14.34 | 7 | 92796 | 72 | 63396147 |
Muscle spasticity | 21.77 | 14.34 | 3 | 92800 | 21791 | 63374428 |
Nail bed tenderness | 21.63 | 14.34 | 11 | 92792 | 398 | 63395821 |
Herpes zoster | 21.63 | 14.34 | 56 | 92747 | 82406 | 63313813 |
Hip fracture | 21.62 | 14.34 | 8 | 92795 | 29466 | 63366753 |
Diabetes mellitus | 21.58 | 14.34 | 30 | 92773 | 55780 | 63340439 |
Acral peeling skin syndrome | 21.55 | 14.34 | 5 | 92798 | 12 | 63396207 |
Sclerema | 21.55 | 14.34 | 5 | 92798 | 12 | 63396207 |
Stress | 21.40 | 14.34 | 41 | 92762 | 67126 | 63329093 |
Hormone receptor positive breast cancer | 21.37 | 14.34 | 12 | 92791 | 532 | 63395687 |
Surgery | 21.36 | 14.34 | 13 | 92790 | 35899 | 63360320 |
Kidney infection | 21.34 | 14.34 | 4 | 92799 | 23172 | 63373047 |
Blood pressure increased | 21.26 | 14.34 | 144 | 92659 | 161918 | 63234301 |
Paraparesis | 21.24 | 14.34 | 21 | 92782 | 2227 | 63393992 |
Blood creatine increased | 21.19 | 14.34 | 33 | 92770 | 5568 | 63390651 |
Post-traumatic pain | 21.11 | 14.34 | 11 | 92792 | 419 | 63395800 |
Irritability | 21.00 | 14.34 | 10 | 92793 | 31684 | 63364535 |
Retinal detachment | 20.97 | 14.34 | 34 | 92769 | 5935 | 63390284 |
Underdose | 20.92 | 14.34 | 7 | 92796 | 27449 | 63368770 |
Red cell distribution width increased | 20.88 | 14.34 | 47 | 92756 | 10477 | 63385742 |
Transaminases | 20.80 | 14.34 | 7 | 92796 | 85 | 63396134 |
Lipidosis | 20.76 | 14.34 | 6 | 92797 | 42 | 63396177 |
Neuromuscular toxicity | 20.74 | 14.34 | 8 | 92795 | 147 | 63396072 |
No adverse event | 20.71 | 14.34 | 18 | 92785 | 41387 | 63354832 |
Lung infiltration | 20.68 | 14.34 | 57 | 92746 | 14406 | 63381813 |
Seasonal allergy | 20.66 | 14.34 | 3 | 92800 | 20947 | 63375272 |
Hypoglycaemia | 20.62 | 14.34 | 35 | 92768 | 60030 | 63336189 |
Hypomagnesaemia | 20.60 | 14.34 | 90 | 92713 | 28647 | 63367572 |
Miller Fisher syndrome | 20.51 | 14.34 | 7 | 92796 | 89 | 63396130 |
Chromosomal mutation | 20.50 | 14.34 | 5 | 92798 | 16 | 63396203 |
Metastases to ovary | 20.46 | 14.34 | 11 | 92792 | 447 | 63395772 |
Hypoalbuminaemia | 20.46 | 14.34 | 50 | 92753 | 11755 | 63384464 |
Purtscher retinopathy | 20.37 | 14.34 | 7 | 92796 | 91 | 63396128 |
Lymphangitis | 20.33 | 14.34 | 14 | 92789 | 893 | 63395326 |
Seroma | 20.31 | 14.34 | 20 | 92783 | 2111 | 63394108 |
Hypothalamo-pituitary disorder | 20.20 | 14.34 | 13 | 92790 | 740 | 63395479 |
Neutrophil count abnormal | 20.19 | 14.34 | 23 | 92780 | 2869 | 63393350 |
Neoplasm recurrence | 20.17 | 14.34 | 22 | 92781 | 2616 | 63393603 |
Monocyte count decreased | 20.13 | 14.34 | 20 | 92783 | 2133 | 63394086 |
Hyperkalaemia | 20.11 | 14.34 | 30 | 92773 | 54173 | 63342046 |
Mucosal disorder | 20.01 | 14.34 | 20 | 92783 | 2149 | 63394070 |
Intervertebral disc protrusion | 19.98 | 14.34 | 5 | 92798 | 23704 | 63372515 |
Product quality issue | 19.95 | 14.34 | 14 | 92789 | 35851 | 63360368 |
White blood cell count abnormal | 19.85 | 14.34 | 34 | 92769 | 6208 | 63390011 |
Pituitary tumour | 19.77 | 14.34 | 14 | 92789 | 934 | 63395285 |
Hydrocephalus | 19.74 | 14.34 | 31 | 92772 | 5269 | 63390950 |
Aggression | 19.72 | 14.34 | 5 | 92798 | 23493 | 63372726 |
Infection | 19.72 | 14.34 | 227 | 92576 | 228946 | 63167273 |
Retinitis pigmentosa | 19.70 | 14.34 | 7 | 92796 | 101 | 63396118 |
Gastritis | 19.68 | 14.34 | 107 | 92696 | 37196 | 63359023 |
Dysarthria | 19.67 | 14.34 | 20 | 92783 | 42691 | 63353528 |
Pulmonary toxicity | 19.63 | 14.34 | 43 | 92760 | 9412 | 63386807 |
Sciatica | 19.62 | 14.34 | 13 | 92790 | 34311 | 63361908 |
Therapy non-responder | 19.56 | 14.34 | 52 | 92751 | 75849 | 63320370 |
Carcinoembryonic antigen increased | 19.55 | 14.34 | 18 | 92785 | 1747 | 63394472 |
Leukaemia cutis | 19.51 | 14.34 | 7 | 92796 | 104 | 63396115 |
Chemical peritonitis | 19.45 | 14.34 | 7 | 92796 | 105 | 63396114 |
Acute respiratory distress syndrome | 19.45 | 14.34 | 77 | 92726 | 23457 | 63372762 |
Breast oedema | 19.44 | 14.34 | 6 | 92797 | 54 | 63396165 |
Oestradiol abnormal | 19.44 | 14.34 | 6 | 92797 | 54 | 63396165 |
Congenital syphilitic osteochondritis | 19.44 | 14.34 | 5 | 92798 | 21 | 63396198 |
Arteritis | 19.35 | 14.34 | 12 | 92791 | 640 | 63395579 |
Procedural pain | 19.27 | 14.34 | 4 | 92799 | 21565 | 63374654 |
Paralysis recurrent laryngeal nerve | 19.25 | 14.34 | 6 | 92797 | 56 | 63396163 |
Full blood count decreased | 19.20 | 14.34 | 7 | 92796 | 26017 | 63370202 |
Muscle necrosis | 19.08 | 14.34 | 12 | 92791 | 656 | 63395563 |
Ear pain | 18.93 | 14.34 | 15 | 92788 | 36103 | 63360116 |
Tympanic membrane disorder | 18.81 | 14.34 | 8 | 92795 | 191 | 63396028 |
Sleep disorder | 18.74 | 14.34 | 59 | 92744 | 81507 | 63314712 |
Distichiasis | 18.73 | 14.34 | 5 | 92798 | 25 | 63396194 |
Chills | 18.55 | 14.34 | 250 | 92553 | 113128 | 63283091 |
Limb injury | 18.55 | 14.34 | 7 | 92796 | 25470 | 63370749 |
Amnesia | 18.53 | 14.34 | 33 | 92770 | 55552 | 63340667 |
Carbohydrate antigen 15-3 increased | 18.48 | 14.34 | 16 | 92787 | 1432 | 63394787 |
Gastrointestinal perforation | 18.26 | 14.34 | 24 | 92779 | 3467 | 63392752 |
Metastases to nervous system | 18.20 | 14.34 | 6 | 92797 | 68 | 63396151 |
Feeling hot | 18.14 | 14.34 | 131 | 92672 | 50223 | 63345996 |
Vena cava thrombosis | 18.06 | 14.34 | 19 | 92784 | 2168 | 63394051 |
Drug ineffective for unapproved indication | 18.04 | 14.34 | 14 | 92789 | 34049 | 63362170 |
Phlebitis | 18.03 | 14.34 | 34 | 92769 | 6690 | 63389529 |
Vulvitis | 18.00 | 14.34 | 9 | 92794 | 314 | 63395905 |
Vaginitis gardnerella | 17.96 | 14.34 | 5 | 92798 | 30 | 63396189 |
Gallbladder disorder | 17.89 | 14.34 | 3 | 92800 | 18839 | 63377380 |
Joint dislocation | 17.84 | 14.34 | 3 | 92800 | 18797 | 63377422 |
Dysaesthesia | 17.81 | 14.34 | 27 | 92776 | 4451 | 63391768 |
Memory impairment | 17.80 | 14.34 | 85 | 92718 | 104173 | 63292046 |
Staphylococcal impetigo | 17.74 | 14.34 | 4 | 92799 | 8 | 63396211 |
Emotional distress | 17.72 | 14.34 | 13 | 92790 | 32536 | 63363683 |
Toxic erythema of chemotherapy | 17.69 | 14.34 | 7 | 92796 | 138 | 63396081 |
Femur fracture | 17.64 | 14.34 | 21 | 92782 | 41735 | 63354484 |
Metastases to muscle | 17.55 | 14.34 | 7 | 92796 | 141 | 63396078 |
Vaginal prolapse | 17.51 | 14.34 | 10 | 92793 | 458 | 63395761 |
Axillary vein thrombosis | 17.44 | 14.34 | 9 | 92794 | 336 | 63395883 |
Chemotherapy | 17.29 | 14.34 | 16 | 92787 | 1563 | 63394656 |
Radiation pneumonitis | 17.25 | 14.34 | 16 | 92787 | 1567 | 63394652 |
Viral infection | 17.24 | 14.34 | 16 | 92787 | 35647 | 63360572 |
Laboratory test abnormal | 17.07 | 14.34 | 9 | 92794 | 26903 | 63369316 |
Catheter site bruise | 17.06 | 14.34 | 10 | 92793 | 481 | 63395738 |
Duodenal ulcer | 16.94 | 14.34 | 36 | 92767 | 7720 | 63388499 |
Delirium | 16.85 | 14.34 | 30 | 92773 | 50511 | 63345708 |
Ill-defined disorder | 16.84 | 14.34 | 62 | 92741 | 81693 | 63314526 |
Clostridial infection | 16.79 | 14.34 | 26 | 92777 | 4366 | 63391853 |
Sensory disturbance | 16.77 | 14.34 | 51 | 92752 | 13621 | 63382598 |
Metastases to uterus | 16.67 | 14.34 | 6 | 92797 | 90 | 63396129 |
Breast neoplasm | 16.64 | 14.34 | 15 | 92788 | 1417 | 63394802 |
ALK gene rearrangement positive | 16.59 | 14.34 | 3 | 92800 | 0 | 63396219 |
Labia enlarged | 16.59 | 14.34 | 3 | 92800 | 0 | 63396219 |
Astringent therapy | 16.59 | 14.34 | 3 | 92800 | 0 | 63396219 |
Product administration error | 16.56 | 14.34 | 6 | 92797 | 22391 | 63373828 |
Appendiceal abscess | 16.55 | 14.34 | 8 | 92795 | 259 | 63395960 |
Cardiac tamponade | 16.51 | 14.34 | 27 | 92776 | 4748 | 63391471 |
Rash follicular | 16.40 | 14.34 | 5 | 92798 | 43 | 63396176 |
Herpes simplex sepsis | 16.40 | 14.34 | 5 | 92798 | 43 | 63396176 |
Joint range of motion decreased | 16.33 | 14.34 | 14 | 92789 | 32414 | 63363805 |
Vasculitis | 16.21 | 14.34 | 61 | 92742 | 18148 | 63378071 |
Muscle spasms | 16.17 | 14.34 | 148 | 92655 | 156002 | 63240217 |
Merycism | 16.17 | 14.34 | 8 | 92795 | 273 | 63395946 |
Colitis ischaemic | 16.11 | 14.34 | 43 | 92760 | 10665 | 63385554 |
Pneumonia aspiration | 16.11 | 14.34 | 16 | 92787 | 34524 | 63361695 |
Dandy-Walker syndrome | 16.04 | 14.34 | 6 | 92797 | 101 | 63396118 |
Skin reaction | 16.03 | 14.34 | 53 | 92750 | 14796 | 63381423 |
Chronic kidney disease | 16.01 | 14.34 | 26 | 92777 | 45372 | 63350847 |
Upper limb fracture | 15.99 | 14.34 | 4 | 92799 | 18964 | 63377255 |
Hypervolaemia | 15.92 | 14.34 | 11 | 92792 | 28402 | 63367817 |
Clostridium difficile infection | 15.90 | 14.34 | 86 | 92717 | 29836 | 63366383 |
Hyperaemia | 15.83 | 14.34 | 18 | 92785 | 2241 | 63393978 |
Ischaemic enteritis | 15.82 | 14.34 | 5 | 92798 | 49 | 63396170 |
Injection site rash | 15.79 | 14.34 | 4 | 92799 | 18805 | 63377414 |
Cytotoxic oedema | 15.76 | 14.34 | 7 | 92796 | 186 | 63396033 |
Immunodeficiency | 15.72 | 14.34 | 5 | 92798 | 20249 | 63375970 |
Device dislocation | 15.72 | 14.34 | 9 | 92794 | 25696 | 63370523 |
Abdominal rigidity | 15.69 | 14.34 | 17 | 92786 | 2007 | 63394212 |
Abdominal pain upper | 15.68 | 14.34 | 210 | 92593 | 206234 | 63189985 |
Pseudomembranous colitis | 15.67 | 14.34 | 21 | 92782 | 3091 | 63393128 |
Pain in extremity | 15.65 | 14.34 | 367 | 92436 | 331119 | 63065100 |
Joint effusion | 15.59 | 14.34 | 3 | 92800 | 17057 | 63379162 |
Caesarean section | 15.55 | 14.34 | 3 | 92800 | 17029 | 63379190 |
Appendicitis | 15.50 | 14.34 | 36 | 92767 | 8193 | 63388026 |
Disorientation | 15.46 | 14.34 | 21 | 92782 | 39431 | 63356788 |
Vagus nerve disorder | 15.42 | 14.34 | 6 | 92797 | 113 | 63396106 |
Anal erythema | 15.13 | 14.34 | 7 | 92796 | 205 | 63396014 |
Coating in mouth | 15.10 | 14.34 | 7 | 92796 | 206 | 63396013 |
Pulmonary embolism | 15.06 | 14.34 | 247 | 92556 | 116437 | 63279782 |
Necrosis | 15.03 | 14.34 | 28 | 92775 | 5459 | 63390760 |
Soft tissue infection | 14.93 | 14.34 | 17 | 92786 | 2120 | 63394099 |
Naevus haemorrhage | 14.86 | 14.34 | 6 | 92797 | 125 | 63396094 |
Salmonellosis | 14.85 | 14.34 | 13 | 92790 | 1181 | 63395038 |
Blood glucose decreased | 14.85 | 14.34 | 6 | 92797 | 20946 | 63375273 |
Monocytopenia | 14.84 | 14.34 | 5 | 92798 | 61 | 63396158 |
Urogenital prolapse | 14.82 | 14.34 | 4 | 92799 | 21 | 63396198 |
Pleomorphic adenoma | 14.66 | 14.34 | 4 | 92799 | 22 | 63396197 |
Therapy responder | 14.66 | 14.34 | 8 | 92795 | 335 | 63395884 |
Tumour marker increased | 14.63 | 14.34 | 26 | 92777 | 4889 | 63391330 |
Creatinine renal clearance decreased | 14.62 | 14.34 | 3 | 92800 | 16305 | 63379914 |
Tumour necrosis | 14.60 | 14.34 | 11 | 92792 | 808 | 63395411 |
Peripheral motor neuropathy | 14.59 | 14.34 | 15 | 92788 | 1666 | 63394553 |
Night sweats | 14.52 | 14.34 | 31 | 92772 | 48783 | 63347436 |
Arachnoid cyst | 14.42 | 14.34 | 7 | 92796 | 229 | 63395990 |
Neutrophil count increased | 14.41 | 14.34 | 55 | 92748 | 16472 | 63379747 |
Left ventricular enlargement | 14.41 | 14.34 | 5 | 92798 | 67 | 63396152 |
Product use in unapproved indication | 14.39 | 14.34 | 180 | 92623 | 178900 | 63217319 |
Cardiac arrest | 14.35 | 14.34 | 78 | 92725 | 92467 | 63303752 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1273.03 | 16.56 | 965 | 41519 | 87081 | 34827366 |
Febrile neutropenia | 585.32 | 16.56 | 773 | 41711 | 136076 | 34778371 |
Osteonecrosis of jaw | 547.19 | 16.56 | 314 | 42170 | 17575 | 34896872 |
Prostatic specific antigen increased | 474.01 | 16.56 | 267 | 42217 | 14413 | 34900034 |
Disease progression | 454.61 | 16.56 | 606 | 41878 | 107471 | 34806976 |
Metastases to bone | 417.28 | 16.56 | 229 | 42255 | 11741 | 34902706 |
Neutropenia | 384.95 | 16.56 | 685 | 41799 | 156093 | 34758354 |
Diarrhoea | 320.49 | 16.56 | 1118 | 41366 | 388794 | 34525653 |
Mucosal inflammation | 248.16 | 16.56 | 269 | 42215 | 38353 | 34876094 |
Metastases to lymph nodes | 211.77 | 16.56 | 107 | 42377 | 4621 | 34909826 |
Leukopenia | 177.83 | 16.56 | 293 | 42191 | 62563 | 34851884 |
Neoplasm progression | 172.30 | 16.56 | 175 | 42309 | 23125 | 34891322 |
Alopecia | 167.61 | 16.56 | 176 | 42308 | 24179 | 34890268 |
Stomatitis | 165.49 | 16.56 | 230 | 42254 | 42284 | 34872163 |
Hormone-refractory prostate cancer | 163.98 | 16.56 | 53 | 42431 | 687 | 34913760 |
Neutrophil count decreased | 163.47 | 16.56 | 252 | 42232 | 50852 | 34863595 |
Interstitial lung disease | 160.57 | 16.56 | 286 | 42198 | 64996 | 34849451 |
Pneumonitis | 159.17 | 16.56 | 201 | 42283 | 33677 | 34880770 |
Prostate cancer metastatic | 154.01 | 16.56 | 93 | 42391 | 5710 | 34908737 |
Metastases to lung | 153.79 | 16.56 | 111 | 42373 | 9209 | 34905238 |
Neutropenic sepsis | 151.37 | 16.56 | 129 | 42355 | 13638 | 34900809 |
Onycholysis | 137.92 | 16.56 | 47 | 42437 | 725 | 34913722 |
Metastases to liver | 122.34 | 16.56 | 114 | 42370 | 13549 | 34900898 |
Palmar-plantar erythrodysaesthesia syndrome | 114.87 | 16.56 | 121 | 42363 | 16674 | 34897773 |
Anaemia | 109.00 | 16.56 | 565 | 41919 | 232770 | 34681677 |
Nausea | 101.66 | 16.56 | 733 | 41751 | 339175 | 34575272 |
Product dose omission issue | 101.30 | 16.56 | 13 | 42471 | 119698 | 34794749 |
Dehydration | 99.18 | 16.56 | 365 | 42119 | 129604 | 34784843 |
Portal venous gas | 94.99 | 16.56 | 30 | 42454 | 359 | 34914088 |
Haematotoxicity | 94.63 | 16.56 | 79 | 42405 | 8115 | 34906332 |
Metastases to central nervous system | 94.53 | 16.56 | 79 | 42405 | 8126 | 34906321 |
Septic shock | 91.30 | 16.56 | 241 | 42243 | 71593 | 34842854 |
Drug interaction | 86.87 | 16.56 | 88 | 42396 | 225858 | 34688589 |
Bone marrow failure | 86.20 | 16.56 | 139 | 42345 | 29114 | 34885333 |
Decreased appetite | 85.39 | 16.56 | 414 | 42070 | 165978 | 34748469 |
Neuropathy peripheral | 84.96 | 16.56 | 258 | 42226 | 83005 | 34831442 |
Fall | 83.86 | 16.56 | 74 | 42410 | 202811 | 34711636 |
White blood cell count decreased | 82.18 | 16.56 | 279 | 42205 | 95166 | 34819281 |
Skin toxicity | 81.26 | 16.56 | 58 | 42426 | 4726 | 34909721 |
Polyneuropathy | 75.73 | 16.56 | 92 | 42392 | 14804 | 34899643 |
Hypocalcaemia | 75.12 | 16.56 | 118 | 42366 | 24171 | 34890276 |
Peripheral sensory neuropathy | 67.55 | 16.56 | 60 | 42424 | 6700 | 34907747 |
Headache | 63.42 | 16.56 | 91 | 42393 | 200544 | 34713903 |
Recall phenomenon | 61.74 | 16.56 | 24 | 42460 | 547 | 34913900 |
Metastasis | 60.81 | 16.56 | 46 | 42438 | 4098 | 34910349 |
Bacterial translocation | 60.74 | 16.56 | 21 | 42463 | 339 | 34914108 |
General physical health deterioration | 59.97 | 16.56 | 311 | 42173 | 127958 | 34786489 |
Prostate cancer | 59.76 | 16.56 | 142 | 42342 | 39507 | 34874940 |
Tremor | 58.88 | 16.56 | 14 | 42470 | 82573 | 34831874 |
Nasopharyngitis | 58.20 | 16.56 | 8 | 42476 | 69960 | 34844487 |
Bone pain | 57.83 | 16.56 | 96 | 42388 | 20590 | 34893857 |
Oesophagobronchial fistula | 56.67 | 16.56 | 17 | 42467 | 169 | 34914278 |
Pneumatosis intestinalis | 56.36 | 16.56 | 43 | 42441 | 3880 | 34910567 |
Fatigue | 55.81 | 16.56 | 691 | 41793 | 369962 | 34544485 |
Osteonecrosis | 55.57 | 16.56 | 79 | 42405 | 14811 | 34899636 |
Delusion of grandeur | 54.13 | 16.56 | 27 | 42457 | 1133 | 34913314 |
Weight increased | 51.96 | 16.56 | 24 | 42460 | 93009 | 34821438 |
Nail disorder | 51.78 | 16.56 | 32 | 42452 | 2047 | 34912400 |
Pleural effusion | 51.55 | 16.56 | 216 | 42268 | 81330 | 34833117 |
Bone lesion | 50.50 | 16.56 | 36 | 42448 | 2927 | 34911520 |
Radiation skin injury | 49.10 | 16.56 | 22 | 42462 | 723 | 34913724 |
Oesophageal fistula | 48.69 | 16.56 | 17 | 42467 | 283 | 34914164 |
Pulmonary toxicity | 46.93 | 16.56 | 47 | 42437 | 6100 | 34908347 |
Agitation | 46.71 | 16.56 | 7 | 42477 | 57392 | 34857055 |
Vomiting | 45.89 | 16.56 | 481 | 42003 | 247140 | 34667307 |
Depression | 45.66 | 16.56 | 31 | 42453 | 97067 | 34817380 |
Reproductive toxicity | 45.20 | 16.56 | 9 | 42475 | 9 | 34914438 |
Insomnia | 45.20 | 16.56 | 36 | 42448 | 103871 | 34810576 |
Therapy partial responder | 45.03 | 16.56 | 57 | 42427 | 9559 | 34904888 |
Urinary tract toxicity | 44.71 | 16.56 | 9 | 42475 | 10 | 34914437 |
Rhabdomyolysis | 44.01 | 16.56 | 14 | 42470 | 68149 | 34846298 |
Colon cancer stage III | 43.06 | 16.56 | 14 | 42470 | 185 | 34914262 |
Inappropriate schedule of product administration | 41.65 | 16.56 | 12 | 42472 | 62284 | 34852163 |
Pyrexia | 41.02 | 16.56 | 599 | 41885 | 332414 | 34582033 |
Onychomadesis | 40.85 | 16.56 | 18 | 42466 | 568 | 34913879 |
Myelosuppression | 40.53 | 16.56 | 79 | 42405 | 19186 | 34895261 |
Neutropenic colitis | 39.84 | 16.56 | 32 | 42452 | 3112 | 34911335 |
Prostate cancer recurrent | 39.80 | 16.56 | 21 | 42463 | 992 | 34913455 |
Musculoskeletal stiffness | 39.62 | 16.56 | 5 | 42479 | 46675 | 34867772 |
Somnolence | 39.60 | 16.56 | 46 | 42438 | 111070 | 34803377 |
Rhinalgia | 39.04 | 16.56 | 21 | 42463 | 1032 | 34913415 |
Cardiac failure congestive | 38.59 | 16.56 | 27 | 42457 | 83243 | 34831204 |
Metastases to skin | 38.50 | 16.56 | 16 | 42468 | 436 | 34914011 |
Intentional product misuse | 38.43 | 16.56 | 5 | 42479 | 45606 | 34868841 |
Asthma | 37.62 | 16.56 | 4 | 42480 | 42652 | 34871795 |
Paronychia | 37.60 | 16.56 | 32 | 42452 | 3373 | 34911074 |
Gastric perforation | 37.03 | 16.56 | 28 | 42456 | 2492 | 34911955 |
Plasma cell myeloma | 36.93 | 16.56 | 4 | 42480 | 42033 | 34872414 |
Overdose | 36.61 | 16.56 | 34 | 42450 | 91025 | 34823422 |
Hallucination | 36.17 | 16.56 | 9 | 42475 | 51489 | 34862958 |
Drug hypersensitivity | 36.16 | 16.56 | 27 | 42457 | 80502 | 34833945 |
Metastases to meninges | 35.25 | 16.56 | 22 | 42462 | 1432 | 34913015 |
Erythema | 35.23 | 16.56 | 206 | 42278 | 88574 | 34825873 |
Acute motor-sensory axonal neuropathy | 35.19 | 16.56 | 11 | 42473 | 127 | 34914320 |
Disseminated intravascular coagulation | 34.90 | 16.56 | 80 | 42404 | 21736 | 34892711 |
Dizziness | 34.85 | 16.56 | 142 | 42342 | 218379 | 34696068 |
Colitis | 34.79 | 16.56 | 113 | 42371 | 37637 | 34876810 |
Joint swelling | 34.13 | 16.56 | 15 | 42469 | 59875 | 34854572 |
Injection site pain | 33.54 | 16.56 | 4 | 42480 | 39001 | 34875446 |
Dermatitis | 33.52 | 16.56 | 49 | 42435 | 9419 | 34905028 |
Exposed bone in jaw | 33.50 | 16.56 | 22 | 42462 | 1564 | 34912883 |
Agranulocytosis | 33.41 | 16.56 | 83 | 42401 | 23738 | 34890709 |
Hypophagia | 32.95 | 16.56 | 83 | 42401 | 23939 | 34890508 |
Suicidal ideation | 32.69 | 16.56 | 5 | 42479 | 40383 | 34874064 |
Carbohydrate antigen 15-3 increased | 32.08 | 16.56 | 9 | 42475 | 69 | 34914378 |
Blood pressure increased | 31.89 | 16.56 | 36 | 42448 | 88066 | 34826381 |
Necrotising retinitis | 31.80 | 16.56 | 17 | 42467 | 825 | 34913622 |
Nail toxicity | 31.77 | 16.56 | 8 | 42476 | 38 | 34914409 |
Myocardial infarction | 31.65 | 16.56 | 62 | 42422 | 121023 | 34793424 |
Anxiety | 31.46 | 16.56 | 45 | 42439 | 99383 | 34815064 |
Second primary malignancy | 31.15 | 16.56 | 43 | 42441 | 7843 | 34906604 |
Bone disorder | 30.96 | 16.56 | 38 | 42446 | 6177 | 34908270 |
Gastrointestinal toxicity | 30.94 | 16.56 | 26 | 42458 | 2693 | 34911754 |
Urticaria | 30.56 | 16.56 | 19 | 42465 | 62358 | 34852089 |
Pneumothorax | 30.52 | 16.56 | 70 | 42414 | 19022 | 34895425 |
Muscle spasms | 30.15 | 16.56 | 28 | 42456 | 74973 | 34839474 |
Polyneuropathy in malignant disease | 29.00 | 16.56 | 11 | 42473 | 234 | 34914213 |
Lymphocyte count abnormal | 28.72 | 16.56 | 18 | 42466 | 1180 | 34913267 |
Eubacterium infection | 28.57 | 16.56 | 5 | 42479 | 0 | 34914447 |
Karnofsky scale worsened | 28.57 | 16.56 | 5 | 42479 | 0 | 34914447 |
Contusion | 28.32 | 16.56 | 5 | 42479 | 36359 | 34878088 |
Metastases to pleura | 28.30 | 16.56 | 13 | 42471 | 453 | 34913994 |
Flushing | 28.05 | 16.56 | 95 | 42389 | 32325 | 34882122 |
Metastases to spine | 27.95 | 16.56 | 24 | 42460 | 2560 | 34911887 |
BRCA1 gene mutation | 27.67 | 16.56 | 7 | 42477 | 34 | 34914413 |
Cerebrovascular accident | 27.20 | 16.56 | 38 | 42446 | 84773 | 34829674 |
Intestinal ischaemia | 27.10 | 16.56 | 40 | 42444 | 7754 | 34906693 |
Macroenzyme creatine kinase | 26.51 | 16.56 | 6 | 42478 | 16 | 34914431 |
Gastrointestinal ischaemia | 26.49 | 16.56 | 10 | 42474 | 210 | 34914237 |
Carotid artery aneurysm | 26.29 | 16.56 | 7 | 42477 | 43 | 34914404 |
Superior mesenteric artery syndrome | 26.28 | 16.56 | 8 | 42476 | 84 | 34914363 |
Mediastinitis | 26.14 | 16.56 | 14 | 42470 | 682 | 34913765 |
Metastases to soft tissue | 25.97 | 16.56 | 12 | 42472 | 424 | 34914023 |
Sinusitis | 25.85 | 16.56 | 9 | 42475 | 41393 | 34873054 |
Death | 25.49 | 16.56 | 648 | 41836 | 397401 | 34517046 |
Pancreatitis viral | 25.11 | 16.56 | 5 | 42479 | 5 | 34914442 |
Feeling abnormal | 24.95 | 16.56 | 24 | 42460 | 63211 | 34851236 |
Acute febrile neutrophilic dermatosis | 24.94 | 16.56 | 17 | 42467 | 1286 | 34913161 |
Rash | 24.65 | 16.56 | 164 | 42320 | 222588 | 34691859 |
Nicotinic acid deficiency | 24.45 | 16.56 | 8 | 42476 | 108 | 34914339 |
Rheumatoid arthritis | 24.41 | 16.56 | 8 | 42476 | 38230 | 34876217 |
VIth nerve paralysis | 23.77 | 16.56 | 14 | 42470 | 820 | 34913627 |
Arthralgia | 23.77 | 16.56 | 116 | 42368 | 169925 | 34744522 |
Dysphagia | 23.61 | 16.56 | 143 | 42341 | 62238 | 34852209 |
Blood glucose increased | 23.35 | 16.56 | 28 | 42456 | 66690 | 34847757 |
Prostatic specific antigen abnormal | 22.99 | 16.56 | 13 | 42471 | 705 | 34913742 |
Transdifferentiation of neoplasm | 22.95 | 16.56 | 7 | 42477 | 74 | 34914373 |
Nail ridging | 22.76 | 16.56 | 8 | 42476 | 136 | 34914311 |
Atypical haemolytic uraemic syndrome | 22.71 | 16.56 | 10 | 42474 | 315 | 34914132 |
Tumour pain | 22.64 | 16.56 | 15 | 42469 | 1082 | 34913365 |
Osteoradionecrosis | 22.62 | 16.56 | 7 | 42477 | 78 | 34914369 |
Hydronephrosis | 22.46 | 16.56 | 43 | 42441 | 10303 | 34904144 |
Affective disorder | 22.27 | 16.56 | 27 | 42457 | 4333 | 34910114 |
Pharyngeal abscess | 22.24 | 16.56 | 11 | 42473 | 453 | 34913994 |
BRCA2 gene mutation | 22.24 | 16.56 | 6 | 42478 | 39 | 34914408 |
Tooth extraction | 22.10 | 16.56 | 28 | 42456 | 4700 | 34909747 |
Chemotherapy | 21.81 | 16.56 | 12 | 42472 | 617 | 34913830 |
Enteritis | 21.70 | 16.56 | 37 | 42447 | 8105 | 34906342 |
Disturbance in attention | 21.48 | 16.56 | 3 | 42481 | 25942 | 34888505 |
Memory impairment | 21.48 | 16.56 | 13 | 42471 | 43305 | 34871142 |
Cholangitis sclerosing | 21.35 | 16.56 | 16 | 42468 | 1405 | 34913042 |
Aorto-oesophageal fistula | 21.27 | 16.56 | 6 | 42478 | 47 | 34914400 |
Non-small cell lung cancer | 21.11 | 16.56 | 25 | 42459 | 3915 | 34910532 |
Intentional product use issue | 21.04 | 16.56 | 25 | 42459 | 59791 | 34854656 |
Bronchial fistula | 20.63 | 16.56 | 8 | 42476 | 181 | 34914266 |
Free prostate-specific antigen positive | 20.62 | 16.56 | 4 | 42480 | 3 | 34914444 |
Influenza | 20.60 | 16.56 | 18 | 42466 | 49648 | 34864799 |
Oesophagitis | 20.51 | 16.56 | 48 | 42436 | 13213 | 34901234 |
Hypokalaemia | 20.50 | 16.56 | 131 | 42353 | 58083 | 34856364 |
Gastrointestinal necrosis | 20.46 | 16.56 | 23 | 42461 | 3406 | 34911041 |
Abnormal behaviour | 20.41 | 16.56 | 3 | 42481 | 24966 | 34889481 |
Blood creatine phosphokinase increased | 20.18 | 16.56 | 15 | 42469 | 44842 | 34869605 |
Trigeminal nerve paresis | 20.09 | 16.56 | 4 | 42480 | 4 | 34914443 |
Infusion site plaque | 20.09 | 16.56 | 4 | 42480 | 4 | 34914443 |
Laryngeal oedema | 20.03 | 16.56 | 23 | 42461 | 3485 | 34910962 |
Nephrolithiasis | 19.98 | 16.56 | 6 | 42478 | 30327 | 34884120 |
Hyponatraemia | 19.92 | 16.56 | 170 | 42314 | 82521 | 34831926 |
Metastases to bladder | 19.88 | 16.56 | 6 | 42478 | 61 | 34914386 |
Ischaemic enteritis | 19.81 | 16.56 | 5 | 42479 | 24 | 34914423 |
Acute respiratory distress syndrome | 19.80 | 16.56 | 73 | 42411 | 25896 | 34888551 |
Tracheal fistula | 19.59 | 16.56 | 7 | 42477 | 125 | 34914322 |
Eosinophilia | 19.58 | 16.56 | 4 | 42480 | 26218 | 34888229 |
Metastatic neoplasm | 19.42 | 16.56 | 21 | 42463 | 2979 | 34911468 |
Pruritus | 19.18 | 16.56 | 98 | 42386 | 141883 | 34772564 |
Oral candidiasis | 18.91 | 16.56 | 44 | 42440 | 12066 | 34902381 |
Tracheal stenosis | 18.82 | 16.56 | 8 | 42476 | 231 | 34914216 |
Oral pain | 18.77 | 16.56 | 41 | 42443 | 10786 | 34903661 |
Hospitalisation | 18.74 | 16.56 | 25 | 42459 | 56877 | 34857570 |
Neoplasm recurrence | 18.66 | 16.56 | 18 | 42466 | 2231 | 34912216 |
Polyserositis | 18.63 | 16.56 | 8 | 42476 | 237 | 34914210 |
Capillary leak syndrome | 18.60 | 16.56 | 18 | 42466 | 2240 | 34912207 |
Periorbital disorder | 18.60 | 16.56 | 5 | 42479 | 32 | 34914415 |
SARS-CoV-2 test positive | 18.58 | 16.56 | 29 | 42455 | 5904 | 34908543 |
Neutropenic infection | 18.46 | 16.56 | 15 | 42469 | 1483 | 34912964 |
Coma | 18.41 | 16.56 | 17 | 42467 | 45661 | 34868786 |
Aneurysm ruptured | 18.41 | 16.56 | 10 | 42474 | 501 | 34913946 |
Hypophosphataemia | 18.26 | 16.56 | 41 | 42443 | 10985 | 34903462 |
Coating in mouth | 18.07 | 16.56 | 6 | 42478 | 85 | 34914362 |
Heart rate decreased | 18.01 | 16.56 | 8 | 42476 | 31737 | 34882710 |
Irritability | 17.95 | 16.56 | 4 | 42480 | 24686 | 34889761 |
Lactic acidosis | 17.86 | 16.56 | 10 | 42474 | 34762 | 34879685 |
Dacryostenosis acquired | 17.85 | 16.56 | 8 | 42476 | 263 | 34914184 |
Loss of personal independence in daily activities | 17.84 | 16.56 | 9 | 42475 | 33170 | 34881277 |
Scleroderma | 17.82 | 16.56 | 15 | 42469 | 1557 | 34912890 |
Metastases to peritoneum | 17.69 | 16.56 | 16 | 42468 | 1828 | 34912619 |
Toxic erythema of chemotherapy | 17.58 | 16.56 | 6 | 42478 | 93 | 34914354 |
Vascular pseudoaneurysm | 17.34 | 16.56 | 17 | 42467 | 2150 | 34912297 |
Neutrophil count increased | 17.33 | 16.56 | 53 | 42431 | 17093 | 34897354 |
Metastases to the mediastinum | 17.31 | 16.56 | 8 | 42476 | 283 | 34914164 |
Cranial nerve disorder | 17.23 | 16.56 | 10 | 42474 | 570 | 34913877 |
Carotidynia | 17.14 | 16.56 | 3 | 42481 | 0 | 34914447 |
Hyperchromasia | 17.14 | 16.56 | 3 | 42481 | 0 | 34914447 |
Toxicity to various agents | 16.82 | 16.56 | 159 | 42325 | 200203 | 34714244 |
Pain in extremity | 16.70 | 16.56 | 88 | 42396 | 126425 | 34788022 |
Acute interstitial pneumonitis | 16.57 | 16.56 | 9 | 42475 | 451 | 34913996 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1801.82 | 13.37 | 1522 | 113366 | 134468 | 79495032 |
Febrile neutropenia | 1456.33 | 13.37 | 1726 | 113162 | 229273 | 79400227 |
Neutropenia | 1315.31 | 13.37 | 1833 | 113055 | 285877 | 79343623 |
Diarrhoea | 1205.79 | 13.37 | 3365 | 111523 | 877124 | 78752376 |
Myelosuppression | 1120.14 | 13.37 | 707 | 114181 | 39589 | 79589911 |
Disease progression | 1117.26 | 13.37 | 1351 | 113537 | 183011 | 79446489 |
Metastases to bone | 841.83 | 13.37 | 492 | 114396 | 23935 | 79605565 |
Mucosal inflammation | 800.26 | 13.37 | 746 | 114142 | 74834 | 79554666 |
Palmar-plantar erythrodysaesthesia syndrome | 789.74 | 13.37 | 528 | 114360 | 32606 | 79596894 |
Neuropathy peripheral | 722.50 | 13.37 | 952 | 113936 | 140353 | 79489147 |
Metastases to liver | 572.91 | 13.37 | 408 | 114480 | 27906 | 79601594 |
Bone marrow failure | 570.98 | 13.37 | 520 | 114368 | 50587 | 79578913 |
Metastases to central nervous system | 471.58 | 13.37 | 294 | 114594 | 16081 | 79613419 |
Metastases to lung | 468.07 | 13.37 | 304 | 114584 | 17859 | 79611641 |
Ejection fraction decreased | 460.81 | 13.37 | 389 | 114499 | 34188 | 79595312 |
Metastases to lymph nodes | 454.89 | 13.37 | 245 | 114643 | 10152 | 79619348 |
Neutropenic sepsis | 427.04 | 13.37 | 336 | 114552 | 26728 | 79602772 |
Osteonecrosis of jaw | 423.60 | 13.37 | 409 | 114479 | 42817 | 79586683 |
Neoplasm progression | 420.28 | 13.37 | 442 | 114446 | 51240 | 79578260 |
Agranulocytosis | 400.27 | 13.37 | 404 | 114484 | 44626 | 79584874 |
Leukopenia | 377.34 | 13.37 | 634 | 114254 | 115879 | 79513621 |
Neutrophil count decreased | 374.18 | 13.37 | 562 | 114326 | 93397 | 79536103 |
White blood cell count decreased | 337.70 | 13.37 | 800 | 114088 | 187488 | 79442012 |
Prostatic specific antigen increased | 315.62 | 13.37 | 193 | 114695 | 10193 | 79619307 |
Polyneuropathy | 314.16 | 13.37 | 268 | 114620 | 23883 | 79605617 |
Fall | 275.89 | 13.37 | 182 | 114706 | 487447 | 79142053 |
Interstitial lung disease | 273.46 | 13.37 | 541 | 114347 | 112059 | 79517441 |
Rheumatoid arthritis | 271.24 | 13.37 | 6 | 114882 | 208464 | 79421036 |
Nausea | 265.03 | 13.37 | 2311 | 112577 | 954885 | 78674615 |
Onycholysis | 257.18 | 13.37 | 101 | 114787 | 1982 | 79627518 |
Skin toxicity | 256.49 | 13.37 | 156 | 114732 | 8158 | 79621342 |
Stomatitis | 255.93 | 13.37 | 617 | 114271 | 146140 | 79483360 |
Joint swelling | 254.25 | 13.37 | 53 | 114835 | 288593 | 79340907 |
Decreased appetite | 238.59 | 13.37 | 1051 | 113837 | 341367 | 79288133 |
Product dose omission issue | 233.98 | 13.37 | 38 | 114850 | 247499 | 79382001 |
Recall phenomenon | 232.75 | 13.37 | 80 | 114808 | 1057 | 79628443 |
Haematotoxicity | 228.41 | 13.37 | 185 | 114703 | 15334 | 79614166 |
Pleural effusion | 217.03 | 13.37 | 576 | 114312 | 144686 | 79484814 |
Peripheral sensory neuropathy | 214.65 | 13.37 | 166 | 114722 | 12867 | 79616633 |
Drug abuse | 210.38 | 13.37 | 5 | 114883 | 162686 | 79466814 |
Arthropathy | 209.84 | 13.37 | 11 | 114877 | 177100 | 79452400 |
Flushing | 208.14 | 13.37 | 419 | 114469 | 87849 | 79541651 |
Pneumonitis | 201.99 | 13.37 | 335 | 114553 | 60525 | 79568975 |
Alopecia areata | 201.96 | 13.37 | 82 | 114806 | 1761 | 79627739 |
Neutropenic colitis | 201.95 | 13.37 | 117 | 114771 | 5590 | 79623910 |
Bone pain | 196.06 | 13.37 | 315 | 114573 | 55427 | 79574073 |
Therapeutic product effect decreased | 194.69 | 13.37 | 10 | 114878 | 163853 | 79465647 |
Metastasis | 194.22 | 13.37 | 122 | 114766 | 6758 | 79622742 |
Drug ineffective | 191.19 | 13.37 | 856 | 114032 | 1080057 | 78549443 |
Aortitis | 189.33 | 13.37 | 74 | 114814 | 1433 | 79628067 |
Madarosis | 187.27 | 13.37 | 88 | 114800 | 2714 | 79626786 |
Anaemia | 183.47 | 13.37 | 1182 | 113706 | 443833 | 79185667 |
Cardiotoxicity | 182.45 | 13.37 | 147 | 114741 | 12092 | 79617408 |
Vomiting | 181.17 | 13.37 | 1603 | 113285 | 664225 | 78965275 |
Colitis | 180.05 | 13.37 | 354 | 114534 | 72953 | 79556547 |
Contraindicated product administered | 179.89 | 13.37 | 12 | 114876 | 157526 | 79471974 |
Hair texture abnormal | 167.90 | 13.37 | 88 | 114800 | 3446 | 79626054 |
Sinusitis | 167.80 | 13.37 | 38 | 114850 | 195463 | 79434037 |
Erythema | 164.22 | 13.37 | 697 | 114191 | 222593 | 79406907 |
Nail disorder | 161.27 | 13.37 | 135 | 114753 | 11717 | 79617783 |
Hair colour changes | 158.41 | 13.37 | 90 | 114798 | 4142 | 79625358 |
Breast cancer recurrent | 158.39 | 13.37 | 80 | 114808 | 2897 | 79626603 |
Pyrexia | 157.59 | 13.37 | 1580 | 113308 | 677129 | 78952371 |
Weight increased | 157.37 | 13.37 | 103 | 114785 | 277283 | 79352217 |
Alopecia | 152.55 | 13.37 | 699 | 114189 | 230656 | 79398844 |
Metastases to skin | 152.42 | 13.37 | 66 | 114822 | 1673 | 79627827 |
Musculoskeletal stiffness | 152.24 | 13.37 | 33 | 114855 | 174975 | 79454525 |
Drug hypersensitivity | 151.43 | 13.37 | 125 | 114763 | 298791 | 79330709 |
Systemic lupus erythematosus | 145.15 | 13.37 | 7 | 114881 | 121142 | 79508358 |
Drug interaction | 137.72 | 13.37 | 242 | 114646 | 414941 | 79214559 |
Acute myeloid leukaemia | 136.25 | 13.37 | 194 | 114694 | 30691 | 79598809 |
Somnolence | 135.18 | 13.37 | 89 | 114799 | 238892 | 79390608 |
Injection site pain | 131.84 | 13.37 | 16 | 114872 | 129822 | 79499678 |
Confusional state | 131.27 | 13.37 | 159 | 114729 | 317838 | 79311662 |
Nail toxicity | 129.69 | 13.37 | 39 | 114849 | 324 | 79629176 |
Pemphigus | 128.95 | 13.37 | 3 | 114885 | 99579 | 79529921 |
Overdose | 128.83 | 13.37 | 52 | 114836 | 184154 | 79445346 |
Condition aggravated | 128.10 | 13.37 | 338 | 114550 | 500786 | 79128714 |
Gastrointestinal toxicity | 126.42 | 13.37 | 100 | 114788 | 8009 | 79621491 |
Second primary malignancy | 126.09 | 13.37 | 128 | 114760 | 14222 | 79615278 |
Hand deformity | 124.51 | 13.37 | 6 | 114882 | 103913 | 79525587 |
Dehydration | 124.29 | 13.37 | 694 | 114194 | 247493 | 79382007 |
Capillary leak syndrome | 121.97 | 13.37 | 74 | 114814 | 3851 | 79625649 |
Left ventricular dysfunction | 118.68 | 13.37 | 143 | 114745 | 19218 | 79610282 |
Breast cancer metastatic | 117.07 | 13.37 | 98 | 114790 | 8504 | 79620996 |
Lymphoedema | 116.95 | 13.37 | 115 | 114773 | 12298 | 79617202 |
Paronychia | 114.72 | 13.37 | 93 | 114795 | 7715 | 79621785 |
Radiation skin injury | 114.59 | 13.37 | 51 | 114837 | 1383 | 79628117 |
Abdominal discomfort | 113.72 | 13.37 | 116 | 114772 | 250611 | 79378889 |
Lacrimation increased | 112.40 | 13.37 | 150 | 114738 | 22327 | 79607173 |
Therapy partial responder | 110.76 | 13.37 | 131 | 114757 | 17266 | 79612234 |
Metastases to pleura | 110.67 | 13.37 | 51 | 114837 | 1503 | 79627997 |
Myocardial infarction | 110.45 | 13.37 | 64 | 114824 | 184065 | 79445435 |
Dermatitis | 109.25 | 13.37 | 144 | 114744 | 21177 | 79608323 |
Biopsy lung abnormal | 105.27 | 13.37 | 28 | 114860 | 140 | 79629360 |
Product use issue | 104.66 | 13.37 | 89 | 114799 | 209733 | 79419767 |
Inappropriate schedule of product administration | 101.43 | 13.37 | 33 | 114855 | 133595 | 79495905 |
Contusion | 100.80 | 13.37 | 44 | 114844 | 148732 | 79480768 |
Portal venous gas | 100.20 | 13.37 | 33 | 114855 | 379 | 79629121 |
Headache | 99.96 | 13.37 | 544 | 114344 | 653228 | 78976272 |
Maternal exposure during pregnancy | 99.69 | 13.37 | 36 | 114852 | 136502 | 79492998 |
Metastases to meninges | 99.50 | 13.37 | 63 | 114825 | 3538 | 79625962 |
Wound | 98.82 | 13.37 | 23 | 114865 | 116156 | 79513344 |
Dysgeusia | 98.06 | 13.37 | 239 | 114649 | 56938 | 79572562 |
Fatigue | 97.39 | 13.37 | 1878 | 113010 | 927849 | 78701651 |
Intentional product use issue | 93.92 | 13.37 | 51 | 114837 | 152061 | 79477439 |
Hepatic enzyme increased | 90.41 | 13.37 | 78 | 114810 | 182532 | 79446968 |
Cerebrovascular accident | 87.55 | 13.37 | 58 | 114830 | 155234 | 79474266 |
Dermatitis acneiform | 87.55 | 13.37 | 89 | 114799 | 9904 | 79619596 |
Nail dystrophy | 87.33 | 13.37 | 38 | 114850 | 975 | 79628525 |
Suicide attempt | 87.26 | 13.37 | 9 | 114879 | 82923 | 79546577 |
Septic shock | 86.84 | 13.37 | 379 | 114509 | 122422 | 79507078 |
Depression | 86.67 | 13.37 | 111 | 114777 | 216679 | 79412821 |
Injury | 82.61 | 13.37 | 8 | 114880 | 77488 | 79552012 |
Myositis | 82.48 | 13.37 | 119 | 114769 | 19049 | 79610451 |
Acute promyelocytic leukaemia | 82.06 | 13.37 | 41 | 114847 | 1450 | 79628050 |
Pain | 81.95 | 13.37 | 636 | 114252 | 703166 | 78926334 |
Metastases to peritoneum | 81.55 | 13.37 | 60 | 114828 | 4312 | 79625188 |
Mobility decreased | 81.39 | 13.37 | 37 | 114851 | 122138 | 79507362 |
Skin exfoliation | 80.68 | 13.37 | 217 | 114671 | 54883 | 79574617 |
Blood pressure systolic increased | 79.81 | 13.37 | 4 | 114884 | 66982 | 79562518 |
Arthritis | 79.37 | 13.37 | 33 | 114855 | 114847 | 79514653 |
Loss of personal independence in daily activities | 78.43 | 13.37 | 25 | 114863 | 102555 | 79526945 |
Hypokalaemia | 76.20 | 13.37 | 409 | 114479 | 143631 | 79485869 |
Lymphangiosis carcinomatosa | 75.79 | 13.37 | 44 | 114844 | 2110 | 79627390 |
Feeling abnormal | 75.21 | 13.37 | 71 | 114817 | 159128 | 79470372 |
Organising pneumonia | 74.02 | 13.37 | 85 | 114803 | 10854 | 79618646 |
Neutropenic infection | 73.47 | 13.37 | 45 | 114843 | 2382 | 79627118 |
Helicobacter infection | 72.22 | 13.37 | 8 | 114880 | 69696 | 79559804 |
Arthralgia | 71.62 | 13.37 | 506 | 114382 | 571297 | 79058203 |
Hypocalcaemia | 71.48 | 13.37 | 195 | 114693 | 49729 | 79579771 |
Osteoarthritis | 70.92 | 13.37 | 19 | 114869 | 87290 | 79542210 |
Multifocal micronodular pneumocyte hyperplasia | 70.73 | 13.37 | 18 | 114870 | 73 | 79629427 |
Blood cholesterol increased | 70.35 | 13.37 | 17 | 114871 | 83703 | 79545797 |
Bronchial polyp | 70.34 | 13.37 | 18 | 114870 | 75 | 79629425 |
Gastrointestinal necrosis | 68.79 | 13.37 | 60 | 114828 | 5505 | 79623995 |
Pseudocirrhosis | 66.86 | 13.37 | 28 | 114860 | 652 | 79628848 |
Nail discolouration | 66.69 | 13.37 | 46 | 114842 | 2985 | 79626515 |
Hormone-refractory prostate cancer | 66.42 | 13.37 | 25 | 114863 | 435 | 79629065 |
Medication error | 66.01 | 13.37 | 10 | 114878 | 68632 | 79560868 |
Prostate cancer metastatic | 65.89 | 13.37 | 51 | 114837 | 3956 | 79625544 |
Metastases to chest wall | 65.79 | 13.37 | 26 | 114862 | 519 | 79628981 |
Hallucination | 65.37 | 13.37 | 21 | 114867 | 85724 | 79543776 |
Vascular device infection | 64.78 | 13.37 | 77 | 114811 | 10199 | 79619301 |
Metastases to spine | 64.58 | 13.37 | 52 | 114836 | 4272 | 79625228 |
Pulmonary toxicity | 64.28 | 13.37 | 86 | 114802 | 12828 | 79616672 |
Febrile bone marrow aplasia | 63.73 | 13.37 | 86 | 114802 | 12934 | 79616566 |
Hospitalisation | 63.61 | 13.37 | 28 | 114860 | 94208 | 79535292 |
Toxicity to various agents | 62.52 | 13.37 | 354 | 114534 | 421186 | 79208314 |
Exposure during pregnancy | 62.28 | 13.37 | 34 | 114854 | 101098 | 79528402 |
Sedation | 62.14 | 13.37 | 3 | 114885 | 51892 | 79577608 |
Asthma | 61.78 | 13.37 | 62 | 114826 | 135033 | 79494467 |
Nasal congestion | 61.54 | 13.37 | 17 | 114871 | 76535 | 79552965 |
Pericarditis | 61.40 | 13.37 | 37 | 114851 | 104199 | 79525301 |
Drug intolerance | 60.83 | 13.37 | 187 | 114701 | 263932 | 79365568 |
Anxiety | 60.82 | 13.37 | 171 | 114717 | 248341 | 79381159 |
Thrombocytopenia | 60.48 | 13.37 | 616 | 114272 | 264643 | 79364857 |
Tremor | 60.12 | 13.37 | 95 | 114793 | 169988 | 79459512 |
Intestinal ischaemia | 59.47 | 13.37 | 84 | 114804 | 13186 | 79616314 |
Neurotoxicity | 59.06 | 13.37 | 139 | 114749 | 32379 | 79597121 |
Intentional product misuse | 58.59 | 13.37 | 32 | 114856 | 95133 | 79534367 |
Dacryostenosis acquired | 58.57 | 13.37 | 24 | 114864 | 528 | 79628972 |
Injection site erythema | 58.12 | 13.37 | 20 | 114868 | 78177 | 79551323 |
Irritable bowel syndrome | 57.76 | 13.37 | 10 | 114878 | 62231 | 79567269 |
COVID-19 | 57.72 | 13.37 | 86 | 114802 | 157588 | 79471912 |
Glossodynia | 57.69 | 13.37 | 39 | 114849 | 103298 | 79526202 |
Muscle injury | 57.53 | 13.37 | 3 | 114885 | 48558 | 79580942 |
Injection site reaction | 57.49 | 13.37 | 6 | 114882 | 54779 | 79574721 |
Epistaxis | 57.18 | 13.37 | 314 | 114574 | 111201 | 79518299 |
Mucosal infection | 56.55 | 13.37 | 23 | 114865 | 496 | 79629004 |
Large intestine perforation | 56.30 | 13.37 | 86 | 114802 | 14481 | 79615019 |
Drug reaction with eosinophilia and systemic symptoms | 56.07 | 13.37 | 12 | 114876 | 64232 | 79565268 |
Alopecia totalis | 55.55 | 13.37 | 21 | 114867 | 370 | 79629130 |
Plasma cell myeloma | 55.46 | 13.37 | 6 | 114882 | 53253 | 79576247 |
Aggression | 55.00 | 13.37 | 5 | 114883 | 50953 | 79578547 |
Migraine | 54.48 | 13.37 | 29 | 114859 | 87464 | 79542036 |
C-reactive protein abnormal | 54.27 | 13.37 | 4 | 114884 | 48363 | 79581137 |
Suicidal ideation | 54.25 | 13.37 | 21 | 114867 | 76319 | 79553181 |
Odynophagia | 54.20 | 13.37 | 74 | 114814 | 11253 | 79618247 |
Agitation | 53.86 | 13.37 | 39 | 114849 | 99676 | 79529824 |
Discomfort | 53.70 | 13.37 | 61 | 114827 | 125556 | 79503944 |
Nasopharyngitis | 53.45 | 13.37 | 187 | 114701 | 253694 | 79375806 |
Congestive cardiomyopathy | 53.43 | 13.37 | 75 | 114813 | 11705 | 79617795 |
Electrocardiogram QT prolonged | 53.35 | 13.37 | 32 | 114856 | 90354 | 79539146 |
Swelling | 53.11 | 13.37 | 149 | 114739 | 216562 | 79412938 |
Nephrolithiasis | 53.03 | 13.37 | 7 | 114881 | 53284 | 79576216 |
Dyspnoea | 52.35 | 13.37 | 1609 | 113279 | 855416 | 78774084 |
Treatment failure | 52.33 | 13.37 | 104 | 114784 | 170382 | 79459118 |
Blood pressure fluctuation | 51.97 | 13.37 | 16 | 114872 | 67129 | 79562371 |
Metastatic neoplasm | 51.81 | 13.37 | 49 | 114839 | 4993 | 79624507 |
Systemic scleroderma | 51.77 | 13.37 | 28 | 114860 | 1169 | 79628331 |
Illness | 51.75 | 13.37 | 4 | 114884 | 46507 | 79582993 |
Dizziness | 51.67 | 13.37 | 497 | 114391 | 525944 | 79103556 |
International normalised ratio increased | 51.42 | 13.37 | 29 | 114859 | 84692 | 79544808 |
Coma | 51.01 | 13.37 | 42 | 114846 | 100607 | 79528893 |
Duodenal ulcer perforation | 50.85 | 13.37 | 16 | 114872 | 66195 | 79563305 |
Wheezing | 50.59 | 13.37 | 56 | 114832 | 116608 | 79512892 |
Breast pain | 50.57 | 13.37 | 61 | 114827 | 8204 | 79621296 |
Bradycardia | 50.53 | 13.37 | 73 | 114815 | 135484 | 79494016 |
Device related thrombosis | 50.45 | 13.37 | 37 | 114851 | 2646 | 79626854 |
Injection site swelling | 49.88 | 13.37 | 5 | 114883 | 47127 | 79582373 |
Adverse drug reaction | 49.31 | 13.37 | 17 | 114871 | 66375 | 79563125 |
Lactic acidosis | 48.94 | 13.37 | 20 | 114868 | 70339 | 79559161 |
Hot flush | 48.86 | 13.37 | 182 | 114706 | 54695 | 79574805 |
Oesophagobronchial fistula | 48.49 | 13.37 | 17 | 114871 | 239 | 79629261 |
Acute interstitial pneumonitis | 48.46 | 13.37 | 27 | 114861 | 1196 | 79628304 |
Enterocolitis | 48.28 | 13.37 | 80 | 114808 | 14432 | 79615068 |
Road traffic accident | 47.90 | 13.37 | 4 | 114884 | 43660 | 79585840 |
Carotidynia | 47.50 | 13.37 | 15 | 114873 | 149 | 79629351 |
Back pain | 47.48 | 13.37 | 657 | 114231 | 303523 | 79325977 |
Pneumothorax | 47.07 | 13.37 | 117 | 114771 | 28206 | 79601294 |
Onychomadesis | 46.49 | 13.37 | 47 | 114841 | 5195 | 79624305 |
Drug resistance | 46.27 | 13.37 | 150 | 114738 | 42063 | 79587437 |
Injection site pruritus | 46.04 | 13.37 | 4 | 114884 | 42279 | 79587221 |
Stress | 45.85 | 13.37 | 29 | 114859 | 79583 | 79549917 |
Pneumatosis intestinalis | 45.48 | 13.37 | 51 | 114837 | 6346 | 79623154 |
Hepatic lesion | 45.29 | 13.37 | 53 | 114835 | 6906 | 79622594 |
Rhabdomyolysis | 45.27 | 13.37 | 49 | 114839 | 103082 | 79526418 |
Bone lesion | 45.21 | 13.37 | 49 | 114839 | 5870 | 79623630 |
Oesophageal fistula | 45.07 | 13.37 | 19 | 114869 | 450 | 79629050 |
Tonsillar disorder | 44.91 | 13.37 | 26 | 114862 | 1240 | 79628260 |
Bacterial translocation | 44.89 | 13.37 | 21 | 114867 | 641 | 79628859 |
Hypertension | 44.81 | 13.37 | 286 | 114602 | 330706 | 79298794 |
Angioedema | 44.76 | 13.37 | 27 | 114861 | 76008 | 79553492 |
Erysipelas | 44.71 | 13.37 | 66 | 114822 | 10784 | 79618716 |
Dermatomyositis | 44.66 | 13.37 | 39 | 114849 | 3584 | 79625916 |
Asthenia | 44.58 | 13.37 | 1007 | 113881 | 510682 | 79118818 |
Delusion of grandeur | 44.50 | 13.37 | 27 | 114861 | 1405 | 79628095 |
Insomnia | 44.29 | 13.37 | 192 | 114696 | 244978 | 79384522 |
Swollen tongue | 43.81 | 13.37 | 5 | 114883 | 42565 | 79586935 |
Cystoid macular oedema | 43.45 | 13.37 | 30 | 114858 | 1950 | 79627550 |
Metastases to the mediastinum | 43.38 | 13.37 | 20 | 114868 | 590 | 79628910 |
Onychalgia | 43.22 | 13.37 | 23 | 114865 | 929 | 79628571 |
Mastitis | 42.98 | 13.37 | 31 | 114857 | 2160 | 79627340 |
Periarticular thenar erythema with onycholysis | 42.77 | 13.37 | 11 | 114877 | 47 | 79629453 |
Blood lactate dehydrogenase increased | 42.76 | 13.37 | 139 | 114749 | 39031 | 79590469 |
Urticaria | 42.71 | 13.37 | 131 | 114757 | 185070 | 79444430 |
Performance status decreased | 42.21 | 13.37 | 48 | 114840 | 6065 | 79623435 |
Basal cell carcinoma | 42.20 | 13.37 | 3 | 114885 | 37372 | 79592128 |
Product prescribing error | 42.03 | 13.37 | 7 | 114881 | 44806 | 79584694 |
Type 2 diabetes mellitus | 41.78 | 13.37 | 15 | 114873 | 57107 | 79572393 |
Influenza | 41.57 | 13.37 | 77 | 114811 | 129529 | 79499971 |
Gait disturbance | 40.93 | 13.37 | 157 | 114731 | 207349 | 79422151 |
Hypoglycaemia | 40.59 | 13.37 | 52 | 114836 | 101542 | 79527958 |
PIK3CA-activated mutation | 40.49 | 13.37 | 19 | 114869 | 584 | 79628916 |
Adenocarcinoma | 40.38 | 13.37 | 38 | 114850 | 3848 | 79625652 |
Impaired healing | 40.33 | 13.37 | 40 | 114848 | 87615 | 79541885 |
Metastases to soft tissue | 40.31 | 13.37 | 19 | 114869 | 590 | 79628910 |
Lumbosacral radiculoplexus neuropathy | 39.96 | 13.37 | 11 | 114877 | 64 | 79629436 |
Hyperfibrinogenaemia | 39.87 | 13.37 | 12 | 114876 | 100 | 79629400 |
Accidental overdose | 39.87 | 13.37 | 5 | 114883 | 39576 | 79589924 |
Blood pressure increased | 39.73 | 13.37 | 163 | 114725 | 211197 | 79418303 |
Chemotherapy | 39.45 | 13.37 | 27 | 114861 | 1730 | 79627770 |
Psoriasis | 38.84 | 13.37 | 43 | 114845 | 89544 | 79539956 |
Full blood count abnormal | 38.68 | 13.37 | 6 | 114882 | 40468 | 79589032 |
Device related infection | 38.62 | 13.37 | 123 | 114765 | 34171 | 79595329 |
Myelodysplastic syndrome | 38.15 | 13.37 | 113 | 114775 | 30188 | 79599312 |
Chest discomfort | 38.12 | 13.37 | 334 | 114554 | 137710 | 79491790 |
Computerised tomogram thorax abnormal | 38.07 | 13.37 | 30 | 114858 | 2389 | 79627111 |
Prescribed overdose | 37.64 | 13.37 | 5 | 114883 | 37878 | 79591622 |
Enterocolitis infectious | 37.63 | 13.37 | 32 | 114856 | 2837 | 79626663 |
Bursitis | 37.42 | 13.37 | 4 | 114884 | 35840 | 79593660 |
Cardiac arrest | 37.40 | 13.37 | 125 | 114763 | 171971 | 79457529 |
Granulocyte count decreased | 36.43 | 13.37 | 26 | 114862 | 1782 | 79627718 |
Blood glucose increased | 36.26 | 13.37 | 69 | 114819 | 114906 | 79514594 |
Treatment noncompliance | 36.12 | 13.37 | 15 | 114873 | 52253 | 79577247 |
Cardiomyopathy | 35.93 | 13.37 | 107 | 114781 | 28667 | 79600833 |
EGFR gene mutation | 35.48 | 13.37 | 16 | 114872 | 448 | 79629052 |
Prostate cancer | 35.37 | 13.37 | 117 | 114771 | 33151 | 79596349 |
General physical health deterioration | 35.35 | 13.37 | 575 | 114313 | 274663 | 79354837 |
Cytokine release syndrome | 35.18 | 13.37 | 5 | 114883 | 35993 | 79593507 |
Tongue coated | 35.16 | 13.37 | 23 | 114865 | 1366 | 79628134 |
Gait inability | 34.57 | 13.37 | 21 | 114867 | 58896 | 79570604 |
Peripheral swelling | 34.44 | 13.37 | 237 | 114651 | 269380 | 79360120 |
Exposed bone in jaw | 34.18 | 13.37 | 34 | 114854 | 3686 | 79625814 |
Mastectomy | 33.96 | 13.37 | 21 | 114867 | 1131 | 79628369 |
Unevaluable event | 33.76 | 13.37 | 19 | 114869 | 55566 | 79573934 |
Toxic erythema of chemotherapy | 33.73 | 13.37 | 13 | 114875 | 242 | 79629258 |
Pruritus | 33.61 | 13.37 | 385 | 114503 | 394263 | 79235237 |
Coronary artery disease | 33.57 | 13.37 | 27 | 114861 | 65447 | 79564053 |
Myalgia | 33.56 | 13.37 | 412 | 114476 | 185229 | 79444271 |
Drug level increased | 33.41 | 13.37 | 8 | 114880 | 39643 | 79589857 |
Cellulitis | 33.36 | 13.37 | 270 | 114618 | 108790 | 79520710 |
Dysarthria | 33.30 | 13.37 | 29 | 114859 | 67593 | 79561907 |
Acoustic stimulation tests abnormal | 33.30 | 13.37 | 8 | 114880 | 24 | 79629476 |
Constipation | 32.95 | 13.37 | 582 | 114306 | 282468 | 79347032 |
Blood creatinine decreased | 32.82 | 13.37 | 48 | 114840 | 7777 | 79621723 |
Acute respiratory distress syndrome | 32.66 | 13.37 | 138 | 114750 | 43929 | 79585571 |
Coating in mouth | 32.64 | 13.37 | 13 | 114875 | 265 | 79629235 |
Dyskinesia | 32.34 | 13.37 | 12 | 114876 | 44761 | 79584739 |
Oral candidiasis | 32.21 | 13.37 | 105 | 114783 | 29523 | 79599977 |
Meibomian gland dysfunction | 31.87 | 13.37 | 12 | 114876 | 209 | 79629291 |
Gastric perforation | 31.85 | 13.37 | 34 | 114854 | 4003 | 79625497 |
Nervousness | 31.83 | 13.37 | 5 | 114883 | 33410 | 79596090 |
Ascites | 31.77 | 13.37 | 202 | 114686 | 75360 | 79554140 |
Asthenopia | 31.69 | 13.37 | 27 | 114861 | 2400 | 79627100 |
Vulvovaginal dryness | 31.64 | 13.37 | 26 | 114862 | 2198 | 79627302 |
Hiccups | 31.64 | 13.37 | 54 | 114834 | 9977 | 79619523 |
Gastrointestinal haemorrhage | 31.61 | 13.37 | 108 | 114780 | 147611 | 79481889 |
Frequent bowel movements | 31.61 | 13.37 | 3 | 114885 | 29536 | 79599964 |
Cardiac dysfunction | 31.26 | 13.37 | 34 | 114854 | 4090 | 79625410 |
Carbohydrate antigen 15-3 increased | 31.02 | 13.37 | 20 | 114868 | 1159 | 79628341 |
Gastric disorder | 30.67 | 13.37 | 8 | 114880 | 37425 | 79592075 |
Breast inflammation | 30.66 | 13.37 | 11 | 114877 | 166 | 79629334 |
Neoplasm recurrence | 30.65 | 13.37 | 34 | 114854 | 4180 | 79625320 |
Diabetes mellitus | 30.42 | 13.37 | 41 | 114847 | 78349 | 79551151 |
Disseminated intravascular coagulation | 30.35 | 13.37 | 117 | 114771 | 35725 | 79593775 |
Nephritis bacterial | 30.24 | 13.37 | 8 | 114880 | 39 | 79629461 |
Infusion site plaque | 30.21 | 13.37 | 6 | 114882 | 4 | 79629496 |
Cataract | 30.16 | 13.37 | 27 | 114861 | 62093 | 79567407 |
Arteritis | 30.16 | 13.37 | 18 | 114870 | 909 | 79628591 |
Osteonecrosis | 30.11 | 13.37 | 106 | 114782 | 30989 | 79598511 |
Pulmonary mass | 29.88 | 13.37 | 101 | 114787 | 28933 | 79600567 |
Non-small cell lung cancer | 29.60 | 13.37 | 41 | 114847 | 6319 | 79623181 |
Prostate cancer recurrent | 29.55 | 13.37 | 17 | 114871 | 801 | 79628699 |
Joint range of motion decreased | 29.49 | 13.37 | 6 | 114882 | 33276 | 79596224 |
Blood uric acid decreased | 29.41 | 13.37 | 20 | 114868 | 1268 | 79628232 |
Vascular fragility | 29.38 | 13.37 | 10 | 114878 | 128 | 79629372 |
Injection site haemorrhage | 29.38 | 13.37 | 3 | 114885 | 27867 | 79601633 |
Barotrauma | 29.35 | 13.37 | 11 | 114877 | 189 | 79629311 |
Hydrothorax | 29.32 | 13.37 | 21 | 114867 | 1447 | 79628053 |
Peritonitis | 29.27 | 13.37 | 98 | 114790 | 27938 | 79601562 |
Gas gangrene | 29.16 | 13.37 | 12 | 114876 | 267 | 79629233 |
Therapy interrupted | 29.16 | 13.37 | 5 | 114883 | 31336 | 79598164 |
Joint injury | 29.15 | 13.37 | 5 | 114883 | 31330 | 79598170 |
Limb injury | 29.09 | 13.37 | 4 | 114884 | 29524 | 79599976 |
Eastern Cooperative Oncology Group performance status worsened | 29.08 | 13.37 | 24 | 114864 | 2041 | 79627459 |
Invasive lobular breast carcinoma | 29.00 | 13.37 | 16 | 114872 | 695 | 79628805 |
Balance disorder | 28.89 | 13.37 | 62 | 114826 | 98795 | 79530705 |
Vulvovaginal candidiasis | 28.87 | 13.37 | 26 | 114862 | 2488 | 79627012 |
Ischaemic enteritis | 28.83 | 13.37 | 10 | 114878 | 136 | 79629364 |
Incorrect dose administered | 28.81 | 13.37 | 41 | 114847 | 76589 | 79552911 |
Excessive eye blinking | 28.74 | 13.37 | 22 | 114866 | 1679 | 79627821 |
Periorbital disorder | 28.72 | 13.37 | 8 | 114880 | 49 | 79629451 |
Neck pain | 28.70 | 13.37 | 40 | 114848 | 75377 | 79554123 |
Cystitis noninfective | 28.69 | 13.37 | 20 | 114868 | 1320 | 79628180 |
Obstructive shock | 28.63 | 13.37 | 9 | 114879 | 88 | 79629412 |
Blood alkaline phosphatase increased | 28.53 | 13.37 | 173 | 114715 | 63491 | 79566009 |
Eosinophilia | 28.27 | 13.37 | 15 | 114873 | 45330 | 79584170 |
White blood cell count abnormal | 28.20 | 13.37 | 38 | 114850 | 5707 | 79623793 |
Irritability | 28.12 | 13.37 | 12 | 114876 | 41132 | 79588368 |
Karnofsky scale worsened | 27.72 | 13.37 | 5 | 114883 | 0 | 79629500 |
Eubacterium infection | 27.72 | 13.37 | 5 | 114883 | 0 | 79629500 |
Dysaesthesia | 27.67 | 13.37 | 38 | 114850 | 5810 | 79623690 |
Bronchitis | 27.62 | 13.37 | 96 | 114792 | 130548 | 79498952 |
Perforation | 27.57 | 13.37 | 20 | 114868 | 1406 | 79628094 |
Pancreatitis | 27.49 | 13.37 | 35 | 114853 | 68540 | 79560960 |
Dysphagia | 27.49 | 13.37 | 283 | 114605 | 121853 | 79507647 |
Invasive ductal breast carcinoma | 27.45 | 13.37 | 38 | 114850 | 5854 | 79623646 |
Acquired gene mutation | 27.45 | 13.37 | 24 | 114864 | 2209 | 79627291 |
Delirium | 27.38 | 13.37 | 50 | 114838 | 84577 | 79544923 |
Lymphadenopathy | 27.32 | 13.37 | 150 | 114738 | 53097 | 79576403 |
Laryngeal oedema | 27.29 | 13.37 | 45 | 114843 | 8084 | 79621416 |
Therapy cessation | 27.24 | 13.37 | 10 | 114878 | 37552 | 79591948 |
Feeling hot | 27.20 | 13.37 | 163 | 114725 | 59571 | 79569929 |
Ejection fraction | 27.12 | 13.37 | 24 | 114864 | 2245 | 79627255 |
Adverse event | 27.10 | 13.37 | 28 | 114860 | 60186 | 79569314 |
Oral pain | 27.09 | 13.37 | 104 | 114784 | 31694 | 79597806 |
HER2 positive breast cancer | 26.94 | 13.37 | 12 | 114876 | 326 | 79629174 |
Intestinal perforation | 26.89 | 13.37 | 70 | 114818 | 17356 | 79612144 |
Hepatic function abnormal | 26.86 | 13.37 | 189 | 114699 | 72918 | 79556582 |
Retinal detachment | 26.85 | 13.37 | 48 | 114840 | 9199 | 79620301 |
Tumour pain | 26.85 | 13.37 | 24 | 114864 | 2275 | 79627225 |
Pleural disorder | 26.83 | 13.37 | 17 | 114871 | 956 | 79628544 |
No adverse event | 26.81 | 13.37 | 10 | 114878 | 37182 | 79592318 |
Emotional distress | 26.77 | 13.37 | 12 | 114876 | 39957 | 79589543 |
Radiation necrosis | 26.77 | 13.37 | 13 | 114875 | 432 | 79629068 |
Sepsis | 26.54 | 13.37 | 540 | 114348 | 268888 | 79360612 |
Eosinophil percentage increased | 26.45 | 13.37 | 20 | 114868 | 1498 | 79628002 |
Skin reaction | 26.31 | 13.37 | 66 | 114822 | 16002 | 79613498 |
Pericardial effusion | 26.29 | 13.37 | 134 | 114754 | 46103 | 79583397 |
Axillary pain | 26.22 | 13.37 | 23 | 114865 | 2126 | 79627374 |
Blood creatine phosphokinase increased | 26.22 | 13.37 | 34 | 114854 | 66056 | 79563444 |
Superior mesenteric artery syndrome | 26.15 | 13.37 | 10 | 114878 | 182 | 79629318 |
Nicotinic acid deficiency | 26.15 | 13.37 | 10 | 114878 | 182 | 79629318 |
Drug dependence | 26.14 | 13.37 | 13 | 114875 | 40756 | 79588744 |
Palmar erythema | 26.12 | 13.37 | 22 | 114866 | 1925 | 79627575 |
Hormone receptor positive breast cancer | 26.00 | 13.37 | 12 | 114876 | 355 | 79629145 |
Malignant pleural effusion | 25.85 | 13.37 | 28 | 114860 | 3352 | 79626148 |
Scleroderma renal crisis | 25.83 | 13.37 | 14 | 114874 | 587 | 79628913 |
Product administration error | 25.73 | 13.37 | 7 | 114881 | 31839 | 79597661 |
Metastases to gastrointestinal tract | 25.71 | 13.37 | 9 | 114879 | 126 | 79629374 |
Colitis ulcerative | 25.62 | 13.37 | 9 | 114879 | 34733 | 79594767 |
Menopausal disorder | 25.54 | 13.37 | 7 | 114881 | 40 | 79629460 |
Polyneuropathy in malignant disease | 25.47 | 13.37 | 11 | 114877 | 277 | 79629223 |
Tumour embolism | 25.42 | 13.37 | 10 | 114878 | 197 | 79629303 |
Sopor | 25.30 | 13.37 | 8 | 114880 | 33002 | 79596498 |
Ear infection | 25.25 | 13.37 | 9 | 114879 | 34423 | 79595077 |
Vessel puncture site bruise | 25.04 | 13.37 | 13 | 114875 | 499 | 79629001 |
Hyperchlorhydria | 24.87 | 13.37 | 22 | 114866 | 2057 | 79627443 |
Mucosal disorder | 24.86 | 13.37 | 28 | 114860 | 3500 | 79626000 |
Sleep disorder | 24.81 | 13.37 | 54 | 114834 | 85623 | 79543877 |
Paraesthesia | 24.76 | 13.37 | 374 | 114514 | 175949 | 79453551 |
Acute kidney injury | 24.70 | 13.37 | 565 | 114323 | 518839 | 79110661 |
Muscle spasms | 24.64 | 13.37 | 149 | 114739 | 174581 | 79454919 |
Osteoporosis | 24.54 | 13.37 | 25 | 114863 | 54087 | 79575413 |
Hip fracture | 24.41 | 13.37 | 7 | 114881 | 30754 | 79598746 |
Troponin I increased | 24.27 | 13.37 | 32 | 114856 | 4706 | 79624794 |
Neutrophil count increased | 24.11 | 13.37 | 95 | 114793 | 29301 | 79600199 |
Hypophagia | 24.09 | 13.37 | 129 | 114759 | 45238 | 79584262 |
Depressed level of consciousness | 24.00 | 13.37 | 66 | 114822 | 96586 | 79532914 |
Mouth ulceration | 23.77 | 13.37 | 114 | 114774 | 38280 | 79591220 |
Night sweats | 23.70 | 13.37 | 24 | 114864 | 52071 | 79577429 |
Unintentional medical device removal | 23.65 | 13.37 | 41 | 114847 | 7671 | 79621829 |
Mediastinitis | 23.58 | 13.37 | 15 | 114873 | 849 | 79628651 |
Retinal toxicity | 23.29 | 13.37 | 18 | 114870 | 1393 | 79628107 |
Vein discolouration | 23.26 | 13.37 | 11 | 114877 | 344 | 79629156 |
Heart rate decreased | 23.23 | 13.37 | 41 | 114847 | 70275 | 79559225 |
Metastases to ovary | 23.21 | 13.37 | 11 | 114877 | 346 | 79629154 |
Osteoradionecrosis | 23.05 | 13.37 | 8 | 114880 | 109 | 79629391 |
Procedural pain | 23.04 | 13.37 | 3 | 114885 | 23081 | 79606419 |
Necrotising retinitis | 23.03 | 13.37 | 17 | 114871 | 1228 | 79628272 |
Bone marrow infiltration | 23.01 | 13.37 | 14 | 114874 | 732 | 79628768 |
Ventricular hypokinesia | 22.99 | 13.37 | 45 | 114843 | 9234 | 79620266 |
Viral infection | 22.99 | 13.37 | 17 | 114871 | 42999 | 79586501 |
Gout | 22.91 | 13.37 | 4 | 114884 | 24745 | 79604755 |
Cannabinoid hyperemesis syndrome | 22.88 | 13.37 | 7 | 114881 | 62 | 79629438 |
Joint neoplasm | 22.78 | 13.37 | 7 | 114881 | 63 | 79629437 |
Liver function test abnormal | 22.78 | 13.37 | 36 | 114852 | 64439 | 79565061 |
Cytomegalovirus oesophagitis | 22.77 | 13.37 | 14 | 114874 | 746 | 79628754 |
Haemolytic uraemic syndrome | 22.71 | 13.37 | 30 | 114858 | 4419 | 79625081 |
Cytomegalovirus infection | 22.60 | 13.37 | 17 | 114871 | 42627 | 79586873 |
Folate deficiency | 22.55 | 13.37 | 26 | 114862 | 3334 | 79626166 |
Gastrointestinal ischaemia | 22.54 | 13.37 | 12 | 114876 | 485 | 79629015 |
Amnesia | 22.48 | 13.37 | 35 | 114853 | 63022 | 79566478 |
Respiratory arrest | 22.43 | 13.37 | 30 | 114858 | 57520 | 79571980 |
Osteitis condensans | 22.39 | 13.37 | 6 | 114882 | 31 | 79629469 |
Lymphocyte count abnormal | 22.29 | 13.37 | 18 | 114870 | 1485 | 79628015 |
Red blood cell sedimentation rate increased | 22.26 | 13.37 | 20 | 114868 | 45922 | 79583578 |
Lipoprotein increased | 22.24 | 13.37 | 5 | 114883 | 10 | 79629490 |
Nail infection | 22.18 | 13.37 | 22 | 114866 | 2377 | 79627123 |
Bronchiectasis | 22.13 | 13.37 | 3 | 114885 | 22383 | 79607117 |
Foot deformity | 22.05 | 13.37 | 4 | 114884 | 24070 | 79605430 |
Metastases to thorax | 21.96 | 13.37 | 9 | 114879 | 198 | 79629302 |
Enteritis | 21.91 | 13.37 | 58 | 114830 | 14525 | 79614975 |
Metastases to bone marrow | 21.76 | 13.37 | 14 | 114874 | 808 | 79628692 |
Oesophageal perforation | 21.59 | 13.37 | 18 | 114870 | 1553 | 79627947 |
Poisoning | 21.49 | 13.37 | 5 | 114883 | 25267 | 79604233 |
Full blood count decreased | 21.47 | 13.37 | 6 | 114882 | 26813 | 79602687 |
Abnormal behaviour | 21.34 | 13.37 | 13 | 114875 | 36408 | 79593092 |
Herpes zoster | 21.33 | 13.37 | 66 | 114822 | 93017 | 79536483 |
Acute motor-sensory axonal neuropathy | 21.29 | 13.37 | 11 | 114877 | 418 | 79629082 |
Infection | 21.26 | 13.37 | 234 | 114654 | 241478 | 79388022 |
Pharyngeal abscess | 21.24 | 13.37 | 13 | 114875 | 687 | 79628813 |
Oestradiol abnormal | 21.23 | 13.37 | 6 | 114882 | 39 | 79629461 |
Oesophagitis | 21.15 | 13.37 | 80 | 114808 | 24209 | 79605291 |
Biliary sepsis | 21.14 | 13.37 | 18 | 114870 | 1599 | 79627901 |
Mucocutaneous disorder | 21.11 | 13.37 | 8 | 114880 | 142 | 79629358 |
Lipidosis | 21.10 | 13.37 | 6 | 114882 | 40 | 79629460 |
Salmonellosis | 21.09 | 13.37 | 19 | 114869 | 1819 | 79627681 |
Hyperkalaemia | 21.00 | 13.37 | 89 | 114799 | 114309 | 79515191 |
Colitis ischaemic | 21.00 | 13.37 | 59 | 114829 | 15300 | 79614200 |
Muscle spasticity | 20.94 | 13.37 | 3 | 114885 | 21472 | 79608028 |
Haematochezia | 20.91 | 13.37 | 61 | 114827 | 87584 | 79541916 |
Soft tissue neoplasm | 20.90 | 13.37 | 7 | 114881 | 85 | 79629415 |
Sclerema | 20.85 | 13.37 | 6 | 114882 | 42 | 79629458 |
Radiation pneumonitis | 20.82 | 13.37 | 27 | 114861 | 3906 | 79625594 |
Macroenzyme creatine kinase | 20.81 | 13.37 | 5 | 114883 | 15 | 79629485 |
Therapy responder | 20.72 | 13.37 | 11 | 114877 | 442 | 79629058 |
Aplasia | 20.70 | 13.37 | 39 | 114849 | 7781 | 79621719 |
Panophthalmitis | 20.66 | 13.37 | 8 | 114880 | 151 | 79629349 |
Rhinalgia | 20.59 | 13.37 | 21 | 114867 | 2346 | 79627154 |
Post-traumatic pain | 20.54 | 13.37 | 11 | 114877 | 450 | 79629050 |
Vulvitis | 20.43 | 13.37 | 9 | 114879 | 238 | 79629262 |
Vascular pain | 20.40 | 13.37 | 14 | 114874 | 901 | 79628599 |
Blood triglycerides increased | 20.38 | 13.37 | 3 | 114885 | 21037 | 79608463 |
Throat tightness | 20.37 | 13.37 | 87 | 114801 | 27820 | 79601680 |
Pancreatitis viral | 20.34 | 13.37 | 5 | 114883 | 17 | 79629483 |
Breast neoplasm | 20.16 | 13.37 | 14 | 114874 | 918 | 79628582 |
Nasal disorder | 20.15 | 13.37 | 26 | 114862 | 3743 | 79625757 |
Hepatic encephalopathy | 20.12 | 13.37 | 5 | 114883 | 24161 | 79605339 |
Pain in extremity | 20.11 | 13.37 | 387 | 114501 | 364151 | 79265349 |
Overflow diarrhoea | 20.05 | 13.37 | 8 | 114880 | 164 | 79629336 |
Renal failure | 19.97 | 13.37 | 189 | 114699 | 200779 | 79428721 |
Spinal pain | 19.95 | 13.37 | 58 | 114830 | 15334 | 79614166 |
Memory impairment | 19.85 | 13.37 | 88 | 114800 | 111646 | 79517854 |
Transdifferentiation of neoplasm | 19.80 | 13.37 | 7 | 114881 | 101 | 79629399 |
Multiple sclerosis | 19.78 | 13.37 | 4 | 114884 | 22278 | 79607222 |
Nail ridging | 19.75 | 13.37 | 11 | 114877 | 487 | 79629013 |
Tumour haemorrhage | 19.72 | 13.37 | 27 | 114861 | 4117 | 79625383 |
Toxic optic neuropathy | 19.67 | 13.37 | 15 | 114873 | 1138 | 79628362 |
Necrotising fasciitis | 19.65 | 13.37 | 33 | 114855 | 6017 | 79623483 |
Ocular hyperaemia | 19.64 | 13.37 | 8 | 114880 | 28198 | 79601302 |
Delusion | 19.58 | 13.37 | 3 | 114885 | 20420 | 79609080 |
Disorientation | 19.50 | 13.37 | 38 | 114850 | 62738 | 79566762 |
Hyperpyrexia | 19.49 | 13.37 | 33 | 114855 | 6059 | 79623441 |
Laboratory test abnormal | 19.46 | 13.37 | 8 | 114880 | 28040 | 79601460 |
Trigeminal nerve paresis | 19.41 | 13.37 | 4 | 114884 | 4 | 79629496 |
Eye swelling | 19.27 | 13.37 | 7 | 114881 | 26461 | 79603039 |
Tympanic membrane disorder | 19.23 | 13.37 | 8 | 114880 | 183 | 79629317 |
Colony stimulating factor therapy | 19.23 | 13.37 | 11 | 114877 | 513 | 79628987 |
Clostridium bacteraemia | 19.16 | 13.37 | 10 | 114878 | 388 | 79629112 |
Ovarian necrosis | 19.14 | 13.37 | 5 | 114883 | 23 | 79629477 |
Choroidal effusion | 19.09 | 13.37 | 12 | 114876 | 665 | 79628835 |
VIth nerve paralysis | 19.06 | 13.37 | 17 | 114871 | 1607 | 79627893 |
Hypervolaemia | 19.04 | 13.37 | 20 | 114868 | 42670 | 79586830 |
Nail bed bleeding | 18.95 | 13.37 | 12 | 114876 | 674 | 79628826 |
Metastases to heart | 18.90 | 13.37 | 9 | 114879 | 286 | 79629214 |
Onychoclasis | 18.89 | 13.37 | 31 | 114857 | 5547 | 79623953 |
Salmonella sepsis | 18.84 | 13.37 | 10 | 114878 | 402 | 79629098 |
Nail bed tenderness | 18.79 | 13.37 | 10 | 114878 | 404 | 79629096 |
Surgery | 18.78 | 13.37 | 12 | 114876 | 32754 | 79596746 |
Purtscher retinopathy | 18.75 | 13.37 | 7 | 114881 | 119 | 79629381 |
Retinitis pigmentosa | 18.69 | 13.37 | 7 | 114881 | 120 | 79629380 |
Metastases to nervous system | 18.62 | 13.37 | 6 | 114882 | 64 | 79629436 |
Vaginal prolapse | 18.59 | 13.37 | 9 | 114879 | 297 | 79629203 |
Monocyte count decreased | 18.57 | 13.37 | 23 | 114865 | 3178 | 79626322 |
Vaginitis gardnerella | 18.48 | 13.37 | 5 | 114883 | 27 | 79629473 |
Hepatic cytolysis | 18.42 | 13.37 | 8 | 114880 | 27143 | 79602357 |
Bladder cancer | 18.42 | 13.37 | 3 | 114885 | 19523 | 79609977 |
Restlessness | 18.36 | 13.37 | 24 | 114864 | 46468 | 79583032 |
Recurrent cancer | 18.35 | 13.37 | 21 | 114867 | 2672 | 79626828 |
Iron deficiency anaemia | 18.34 | 13.37 | 7 | 114881 | 25665 | 79603835 |
Subclavian vein thrombosis | 18.17 | 13.37 | 20 | 114868 | 2437 | 79627063 |
Left ventricular dilatation | 18.08 | 13.37 | 14 | 114874 | 1087 | 79628413 |
Abdominal pain | 18.03 | 13.37 | 709 | 114179 | 388860 | 79240640 |
Metastases to uterus | 17.98 | 13.37 | 6 | 114882 | 72 | 79629428 |
Mental status changes | 17.94 | 13.37 | 44 | 114844 | 66915 | 79562585 |
Soft tissue infection | 17.88 | 13.37 | 25 | 114863 | 3887 | 79625613 |
Metabolic acidosis | 17.88 | 13.37 | 60 | 114828 | 82469 | 79547031 |
Mucosal toxicity | 17.84 | 13.37 | 11 | 114877 | 589 | 79628911 |
Catheter site bruise | 17.84 | 13.37 | 10 | 114878 | 448 | 79629052 |
Sarcoma | 17.81 | 13.37 | 13 | 114875 | 923 | 79628577 |
Obstruction gastric | 17.80 | 13.37 | 17 | 114871 | 1753 | 79627747 |
Pulmonary hypertension | 17.80 | 13.37 | 26 | 114862 | 48054 | 79581446 |
Metastases to adrenals | 17.78 | 13.37 | 15 | 114873 | 1315 | 79628185 |
Cardiac failure congestive | 17.76 | 13.37 | 126 | 114762 | 142276 | 79487224 |
Inflammatory carcinoma of the breast | 17.76 | 13.37 | 5 | 114883 | 32 | 79629468 |
Aorto-oesophageal fistula | 17.68 | 13.37 | 6 | 114882 | 76 | 79629424 |
Neuromuscular toxicity | 17.64 | 13.37 | 8 | 114880 | 227 | 79629273 |
Haematoma | 17.64 | 13.37 | 30 | 114858 | 52165 | 79577335 |
Chromosomal mutation | 17.63 | 13.37 | 5 | 114883 | 33 | 79629467 |
Intervertebral disc protrusion | 17.62 | 13.37 | 6 | 114882 | 23615 | 79605885 |
Hypovolaemic shock | 17.61 | 13.37 | 48 | 114840 | 12228 | 79617272 |
Transaminases | 17.61 | 13.37 | 6 | 114882 | 77 | 79629423 |
Respiratory failure | 17.60 | 13.37 | 362 | 114526 | 180549 | 79448951 |
Osteosclerosis | 17.59 | 13.37 | 25 | 114863 | 3946 | 79625554 |
Bone disorder | 17.52 | 13.37 | 64 | 114824 | 19049 | 79610451 |
Hallucination, visual | 17.41 | 13.37 | 13 | 114875 | 32716 | 79596784 |
Acute myocardial infarction | 17.39 | 13.37 | 55 | 114833 | 76981 | 79552519 |
Lip swelling | 17.33 | 13.37 | 20 | 114868 | 40891 | 79588609 |
Grip strength decreased | 17.31 | 13.37 | 5 | 114883 | 21864 | 79607636 |
Pulmonary embolism | 17.21 | 13.37 | 345 | 114543 | 171309 | 79458191 |
Metastases to muscle | 17.20 | 13.37 | 9 | 114879 | 351 | 79629149 |
Appendiceal abscess | 17.13 | 13.37 | 9 | 114879 | 354 | 79629146 |
Hypothalamo-pituitary disorder | 17.07 | 13.37 | 14 | 114874 | 1180 | 79628320 |
Hypersomnia | 16.99 | 13.37 | 6 | 114882 | 23080 | 79606420 |
Traumatic lung injury | 16.89 | 13.37 | 19 | 114869 | 2372 | 79627128 |
Platelet count decreased | 16.85 | 13.37 | 383 | 114505 | 194281 | 79435219 |
Therapeutic response unexpected | 16.85 | 13.37 | 4 | 114884 | 19942 | 79609558 |
Drug ineffective for unapproved indication | 16.82 | 13.37 | 30 | 114858 | 51208 | 79578292 |
Breast oedema | 16.79 | 13.37 | 5 | 114883 | 40 | 79629460 |
Malignant neoplasm of pleura | 16.75 | 13.37 | 7 | 114881 | 162 | 79629338 |
Merycism | 16.75 | 13.37 | 8 | 114880 | 256 | 79629244 |
Gastrointestinal perforation | 16.73 | 13.37 | 31 | 114857 | 6106 | 79623394 |
Sciatica | 16.66 | 13.37 | 14 | 114874 | 33208 | 79596292 |
Abortion spontaneous | 16.65 | 13.37 | 11 | 114877 | 29496 | 79600004 |
ALK gene rearrangement positive | 16.63 | 13.37 | 3 | 114885 | 0 | 79629500 |
Labia enlarged | 16.63 | 13.37 | 3 | 114885 | 0 | 79629500 |
Necrosis | 16.61 | 13.37 | 40 | 114848 | 9453 | 79620047 |
Generalised oedema | 16.61 | 13.37 | 73 | 114815 | 23636 | 79605864 |
Osteolysis | 16.61 | 13.37 | 26 | 114862 | 4472 | 79625028 |
Necrotising colitis | 16.59 | 13.37 | 13 | 114875 | 1027 | 79628473 |
Underdose | 16.59 | 13.37 | 14 | 114874 | 33137 | 79596363 |
Impaired work ability | 16.52 | 13.37 | 4 | 114884 | 19677 | 79609823 |
Hydronephrosis | 16.47 | 13.37 | 59 | 114829 | 17395 | 79612105 |
Upper limb fracture | 16.42 | 13.37 | 3 | 114885 | 17964 | 79611536 |
Carcinoembryonic antigen increased | 16.37 | 13.37 | 18 | 114870 | 2191 | 79627309 |
Renal disorder | 16.35 | 13.37 | 22 | 114866 | 42083 | 79587417 |
Ear pain | 16.30 | 13.37 | 14 | 114874 | 32855 | 79596645 |
Cancer pain | 16.23 | 13.37 | 28 | 114860 | 5217 | 79624283 |
Tumour marker increased | 16.20 | 13.37 | 25 | 114863 | 4247 | 79625253 |
Hepatotoxicity | 16.17 | 13.37 | 128 | 114760 | 51224 | 79578276 |
Subdural haematoma | 16.07 | 13.37 | 13 | 114875 | 31421 | 79598079 |
Skin laceration | 16.06 | 13.37 | 11 | 114877 | 28951 | 79600549 |
Dandy-Walker syndrome | 15.99 | 13.37 | 5 | 114883 | 48 | 79629452 |
Breast cancer | 15.90 | 13.37 | 93 | 114795 | 33688 | 79595812 |
Cranial nerve disorder | 15.84 | 13.37 | 13 | 114875 | 1097 | 79628403 |
Clostridial infection | 15.75 | 13.37 | 29 | 114859 | 5685 | 79623815 |
Blister | 15.75 | 13.37 | 104 | 114784 | 119372 | 79510128 |
Extravasation | 15.72 | 13.37 | 23 | 114865 | 3727 | 79625773 |
Granulocytopenia | 15.71 | 13.37 | 44 | 114844 | 11387 | 79618113 |
Administration site extravasation | 15.64 | 13.37 | 14 | 114874 | 1329 | 79628171 |
Kidney infection | 15.54 | 13.37 | 6 | 114882 | 21845 | 79607655 |
Acne | 15.52 | 13.37 | 10 | 114878 | 27180 | 79602320 |
Hypertransaminasaemia | 15.52 | 13.37 | 45 | 114843 | 11879 | 79617621 |
Dysuria | 15.49 | 13.37 | 126 | 114762 | 50825 | 79578675 |
Leukaemia cutis | 15.49 | 13.37 | 7 | 114881 | 197 | 79629303 |
Immunodeficiency | 15.44 | 13.37 | 6 | 114882 | 21762 | 79607738 |
Herpes simplex sepsis | 15.38 | 13.37 | 5 | 114883 | 55 | 79629445 |
Nasal discomfort | 15.33 | 13.37 | 28 | 114860 | 5455 | 79624045 |
Hernia | 15.27 | 13.37 | 3 | 114885 | 17056 | 79612444 |
Tracheo-oesophageal fistula | 15.26 | 13.37 | 10 | 114878 | 596 | 79628904 |
Epidermolysis | 15.22 | 13.37 | 12 | 114876 | 956 | 79628544 |
Staphylococcal impetigo | 15.21 | 13.37 | 4 | 114884 | 19 | 79629481 |
Metastases to pituitary gland | 15.21 | 13.37 | 4 | 114884 | 19 | 79629481 |
Joint dislocation | 15.12 | 13.37 | 3 | 114885 | 16936 | 79612564 |
Product quality issue | 15.03 | 13.37 | 16 | 114872 | 33924 | 79595576 |
Respiratory tract congestion | 15.01 | 13.37 | 5 | 114883 | 19949 | 79609551 |
Pneumonia salmonella | 14.98 | 13.37 | 5 | 114883 | 60 | 79629440 |
Naevus haemorrhage | 14.94 | 13.37 | 6 | 114882 | 125 | 79629375 |
Urogenital prolapse | 14.88 | 13.37 | 4 | 114884 | 21 | 79629479 |
Sinus bradycardia | 14.81 | 13.37 | 9 | 114879 | 25238 | 79604262 |
Glaucoma | 14.78 | 13.37 | 5 | 114883 | 19756 | 79609744 |
Pituitary tumour | 14.75 | 13.37 | 13 | 114875 | 1209 | 79628291 |
Distichiasis | 14.72 | 13.37 | 4 | 114884 | 22 | 79629478 |
Paralysis recurrent laryngeal nerve | 14.68 | 13.37 | 6 | 114882 | 131 | 79629369 |
Parkinsonism | 14.67 | 13.37 | 3 | 114885 | 16581 | 79612919 |
Haemodialysis | 14.66 | 13.37 | 4 | 114884 | 18164 | 79611336 |
Hyperchromasia | 14.56 | 13.37 | 3 | 114885 | 3 | 79629497 |
Subretinal hyperreflective exudation | 14.56 | 13.37 | 3 | 114885 | 3 | 79629497 |
Sarcomatosis | 14.56 | 13.37 | 3 | 114885 | 3 | 79629497 |
Malaise | 14.50 | 13.37 | 568 | 114320 | 489301 | 79140199 |
Hypoalbuminaemia | 14.48 | 13.37 | 65 | 114823 | 21232 | 79608268 |
Metastases to abdominal cavity | 14.43 | 13.37 | 10 | 114878 | 654 | 79628846 |
Injection site rash | 14.40 | 13.37 | 4 | 114884 | 17950 | 79611550 |
Chronic kidney disease | 14.39 | 13.37 | 48 | 114840 | 66106 | 79563394 |
Folliculitis | 14.36 | 13.37 | 37 | 114851 | 55343 | 79574157 |
Hypersensitivity pneumonitis | 14.34 | 13.37 | 22 | 114866 | 3717 | 79625783 |
Glycosylated haemoglobin increased | 14.18 | 13.37 | 5 | 114883 | 19255 | 79610245 |
Portosplenomesenteric venous thrombosis | 14.15 | 13.37 | 4 | 114884 | 26 | 79629474 |
Fear | 14.11 | 13.37 | 7 | 114881 | 21979 | 79607521 |
Infusion site vesicles | 14.09 | 13.37 | 9 | 114879 | 513 | 79628987 |
Bone cancer metastatic | 14.08 | 13.37 | 7 | 114881 | 245 | 79629255 |
Scleroderma | 13.99 | 13.37 | 27 | 114861 | 5483 | 79624017 |
Hydrocephalus | 13.99 | 13.37 | 36 | 114852 | 8864 | 79620636 |
Neutrophil count abnormal | 13.89 | 13.37 | 21 | 114867 | 3505 | 79625995 |
Atypical pneumonia | 13.87 | 13.37 | 30 | 114858 | 6606 | 79622894 |
Tooth extraction | 13.83 | 13.37 | 41 | 114847 | 10954 | 79618546 |
Loss of consciousness | 13.82 | 13.37 | 165 | 114723 | 167778 | 79461722 |
Cholangitis sclerosing | 13.80 | 13.37 | 18 | 114870 | 2619 | 79626881 |
Liver injury | 13.80 | 13.37 | 39 | 114849 | 56575 | 79572925 |
Chills | 13.78 | 13.37 | 315 | 114573 | 159919 | 79469581 |
Hypomagnesaemia | 13.72 | 13.37 | 115 | 114773 | 46796 | 79582704 |
Spinal stenosis | 13.67 | 13.37 | 3 | 114885 | 15788 | 79613712 |
Breast necrosis | 13.67 | 13.37 | 5 | 114883 | 80 | 79629420 |
Cachexia | 13.63 | 13.37 | 41 | 114847 | 11042 | 79618458 |
Circulatory collapse | 13.61 | 13.37 | 97 | 114791 | 37571 | 79591929 |
Chondritis | 13.61 | 13.37 | 6 | 114882 | 159 | 79629341 |
Acute hepatic failure | 13.55 | 13.37 | 14 | 114874 | 30099 | 79599401 |
Cardio-respiratory arrest | 13.54 | 13.37 | 96 | 114792 | 108414 | 79521086 |
Tracheal stenosis | 13.53 | 13.37 | 8 | 114880 | 397 | 79629103 |
Miller Fisher syndrome | 13.52 | 13.37 | 7 | 114881 | 267 | 79629233 |
None
Source | Code | Description |
---|---|---|
ATC | L01CD02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Taxanes |
FDA PE | N0000175085 | Microtubule Inhibition |
FDA EPC | N0000175592 | Microtubule Inhibitor |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:38068 | antimalarials |
CHEBI has role | CHEBI:47868 | photosensitising agent |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D050257 | Tubulin Modulators |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
Carcinoma of breast | indication | 254838004 | DOID:3459 |
Malignant tumor of head and/or neck | indication | 255056009 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Malignant tumor of prostate | indication | 399068003 | DOID:10283 |
Metastatic Breast Carcinoma | indication | ||
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Malignant tumor of esophagus | off-label use | 363402007 | |
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Invasive Bladder Malignancy | off-label use | ||
Refractory Osteosarcoma | off-label use | ||
Asthenia | contraindication | 13791008 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Cardiac tamponade | contraindication | 35304003 | DOID:115 |
Body fluid retention | contraindication | 43498006 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Diarrhea | contraindication | 62315008 | |
Acute infectious disease | contraindication | 63171007 | |
Peripheral motor neuropathy | contraindication | 95663000 | DOID:683 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Peripheral edema | contraindication | 271809000 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Ascites | contraindication | 389026000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Pleural Effusions | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.9 | acidic |
pKa2 | 11.64 | acidic |
pKa3 | 12.4 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | ID50 | 6.70 | WOMBAT-PK | CHEMBL | |||
Multidrug resistance protein 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Epidermal growth factor receptor | Kinase | INHIBITOR | Kd | 9.09 | WOMBAT-PK | ||||
Substance-K receptor | GPCR | Ki | 6.28 | DRUG MATRIX | |||||
Growth hormone-releasing hormone receptor | GPCR | IC50 | 9.85 | CHEMBL | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Nucleotide-binding oligomerization domain-containing protein 2 | Cytosolic other | IC50 | 5.30 | CHEMBL |
ID | Source |
---|---|
4020968 | VUID |
N0000148441 | NUI |
D02165 | KEGG_DRUG |
1299922 | RXNORM |
4020968 | VANDF |
C0246415 | UMLSCUI |
CHEBI:59809 | CHEBI |
TXL | PDB_CHEM_ID |
CHEMBL3545252 | ChEMBL_ID |
CHEMBL92 | ChEMBL_ID |
D000077143 | MESH_DESCRIPTOR_UI |
DB01248 | DRUGBANK_ID |
6809 | IUPHAR_LIGAND_ID |
15H5577CQD | UNII |
148124 | PUBCHEM_CID |
178776 | MMSL |
180476 | MMSL |
4626 | MMSL |
5984 | MMSL |
d04009 | MMSL |
005187 | NDDF |
005188 | NDDF |
108806006 | SNOMEDCT_US |
386918005 | SNOMEDCT_US |
6621 | INN_ID |
148408-66-6 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9204 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9205 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0016 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0016 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0201 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 32 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0201 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 32 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0365 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0365 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0366 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0366 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0367 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0367 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0368 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0368 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1732 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1732 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2026 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2026 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2956 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4235 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4235 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-5068 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-5068 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7870 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7870 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1020 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1020 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1020 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1021 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1021 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | NDA authorized generic | 30 sections |