Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastics, taxane derivatives | 939 | 114977-28-5 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.15 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 14 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 14, 1996 | FDA | SANOFI AVENTIS US |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1638.93 | 13.47 | 1316 | 80614 | 96351 | 50426843 |
Neutropenia | 1394.84 | 13.47 | 1442 | 80488 | 146523 | 50376671 |
Palmar-plantar erythrodysaesthesia syndrome | 991.39 | 13.47 | 533 | 81397 | 19565 | 50503629 |
Diarrhoea | 935.11 | 13.47 | 2556 | 79374 | 585920 | 49937274 |
Malignant neoplasm progression | 892.42 | 13.47 | 797 | 81133 | 67327 | 50455867 |
Mucosal inflammation | 753.92 | 13.47 | 579 | 81351 | 39563 | 50483631 |
Myelosuppression | 750.30 | 13.47 | 388 | 81542 | 13129 | 50510065 |
Disease progression | 717.95 | 13.47 | 829 | 81101 | 95037 | 50428157 |
Ejection fraction decreased | 693.22 | 13.47 | 410 | 81520 | 18110 | 50505084 |
Neuropathy peripheral | 603.92 | 13.47 | 763 | 81167 | 95994 | 50427200 |
Metastases to bone | 585.01 | 13.47 | 364 | 81566 | 17631 | 50505563 |
Bone marrow failure | 570.78 | 13.47 | 422 | 81508 | 27202 | 50495992 |
Metastases to liver | 509.73 | 13.47 | 348 | 81582 | 19756 | 50503438 |
Drug ineffective | 434.40 | 13.47 | 415 | 81515 | 818918 | 49704276 |
Metastases to lung | 368.47 | 13.47 | 227 | 81703 | 10793 | 50512401 |
Metastases to central nervous system | 356.01 | 13.47 | 224 | 81706 | 11058 | 50512136 |
Metastases to lymph nodes | 334.21 | 13.47 | 182 | 81748 | 6842 | 50516352 |
Rheumatoid arthritis | 306.95 | 13.47 | 4 | 81926 | 202546 | 50320648 |
Neutropenic sepsis | 298.59 | 13.47 | 219 | 81711 | 13928 | 50509266 |
Agranulocytosis | 288.72 | 13.47 | 255 | 81675 | 21166 | 50502028 |
Cardiotoxicity | 277.14 | 13.47 | 161 | 81769 | 6866 | 50516328 |
Polyneuropathy | 265.57 | 13.47 | 192 | 81738 | 11939 | 50511255 |
Skin toxicity | 260.18 | 13.47 | 127 | 81803 | 3786 | 50519408 |
Joint swelling | 259.30 | 13.47 | 43 | 81887 | 245243 | 50277951 |
Neoplasm progression | 251.87 | 13.47 | 272 | 81658 | 28885 | 50494309 |
Leukopenia | 243.15 | 13.47 | 411 | 81519 | 67117 | 50456077 |
Fall | 239.35 | 13.47 | 122 | 81808 | 334810 | 50188384 |
Peripheral sensory neuropathy | 226.01 | 13.47 | 138 | 81792 | 6453 | 50516741 |
Contraindicated product administered | 206.25 | 13.47 | 8 | 81922 | 148950 | 50374244 |
Pleural effusion | 204.75 | 13.47 | 425 | 81505 | 81029 | 50442165 |
Acute myeloid leukaemia | 204.22 | 13.47 | 180 | 81750 | 14894 | 50508300 |
Haematotoxicity | 198.46 | 13.47 | 136 | 81794 | 7759 | 50515435 |
Systemic lupus erythematosus | 196.59 | 13.47 | 7 | 81923 | 140615 | 50382579 |
Breast cancer recurrent | 196.07 | 13.47 | 104 | 81826 | 3704 | 50519490 |
Product dose omission issue | 194.70 | 13.47 | 32 | 81898 | 183806 | 50339388 |
Alopecia areata | 191.42 | 13.47 | 75 | 81855 | 1293 | 50521901 |
Completed suicide | 190.02 | 13.47 | 5 | 81925 | 131884 | 50391310 |
Therapeutic product effect decreased | 189.40 | 13.47 | 7 | 81923 | 136043 | 50387151 |
Stomatitis | 186.12 | 13.47 | 467 | 81463 | 100877 | 50422317 |
Vomiting | 182.49 | 13.47 | 1322 | 80608 | 459436 | 50063758 |
Bone pain | 181.41 | 13.47 | 296 | 81634 | 46933 | 50476261 |
Arthropathy | 177.59 | 13.47 | 23 | 81907 | 157883 | 50365311 |
Left ventricular dysfunction | 176.44 | 13.47 | 142 | 81788 | 10364 | 50512830 |
Decreased appetite | 171.17 | 13.47 | 711 | 81219 | 200212 | 50322982 |
Drug hypersensitivity | 171.01 | 13.47 | 97 | 81833 | 250913 | 50272281 |
Pyrexia | 168.12 | 13.47 | 1121 | 80809 | 379082 | 50144112 |
Neutrophil count decreased | 166.76 | 13.47 | 281 | 81649 | 45745 | 50477449 |
Sinusitis | 165.12 | 13.47 | 37 | 81893 | 170521 | 50352673 |
Colitis | 162.44 | 13.47 | 252 | 81678 | 38277 | 50484917 |
Onycholysis | 162.17 | 13.47 | 66 | 81864 | 1262 | 50521932 |
Nausea | 161.36 | 13.47 | 1795 | 80135 | 703603 | 49819591 |
Madarosis | 158.04 | 13.47 | 79 | 81851 | 2481 | 50520713 |
Condition aggravated | 156.84 | 13.47 | 150 | 81780 | 296908 | 50226286 |
Hair colour changes | 156.29 | 13.47 | 80 | 81850 | 2644 | 50520550 |
Nail disorder | 156.25 | 13.47 | 128 | 81802 | 9580 | 50513614 |
Interstitial lung disease | 152.21 | 13.47 | 293 | 81637 | 52883 | 50470311 |
Neutropenic colitis | 150.43 | 13.47 | 75 | 81855 | 2342 | 50520852 |
Metastasis | 145.91 | 13.47 | 90 | 81840 | 4285 | 50518909 |
Maternal exposure during pregnancy | 142.45 | 13.47 | 41 | 81889 | 159737 | 50363457 |
Abdominal discomfort | 141.99 | 13.47 | 101 | 81829 | 231540 | 50291654 |
Gastrointestinal toxicity | 140.39 | 13.47 | 90 | 81840 | 4587 | 50518607 |
Second primary malignancy | 139.07 | 13.47 | 104 | 81826 | 6810 | 50516384 |
Hand deformity | 136.59 | 13.47 | 6 | 81924 | 100193 | 50423001 |
Hair texture abnormal | 134.26 | 13.47 | 80 | 81850 | 3576 | 50519618 |
Aortitis | 133.36 | 13.47 | 51 | 81879 | 821 | 50522373 |
Metastases to skin | 129.77 | 13.47 | 57 | 81873 | 1326 | 50521868 |
Neutropenic infection | 129.24 | 13.47 | 53 | 81877 | 1034 | 50522160 |
Somnolence | 128.85 | 13.47 | 45 | 81885 | 154940 | 50368254 |
Injection site pain | 127.66 | 13.47 | 15 | 81915 | 111009 | 50412185 |
Erythema | 126.83 | 13.47 | 521 | 81409 | 145893 | 50377301 |
Skin exfoliation | 124.12 | 13.47 | 207 | 81723 | 33405 | 50489789 |
Nail toxicity | 123.47 | 13.47 | 38 | 81892 | 302 | 50522892 |
Breast cancer metastatic | 119.35 | 13.47 | 113 | 81817 | 10251 | 50512943 |
Flushing | 116.91 | 13.47 | 303 | 81627 | 66712 | 50456482 |
Weight increased | 116.05 | 13.47 | 94 | 81836 | 201797 | 50321397 |
Confusional state | 115.31 | 13.47 | 80 | 81850 | 185848 | 50337346 |
Neurotoxicity | 114.30 | 13.47 | 130 | 81800 | 14610 | 50508584 |
Lymphoedema | 111.87 | 13.47 | 103 | 81827 | 9019 | 50514175 |
Treatment failure | 109.29 | 13.47 | 43 | 81887 | 137594 | 50385600 |
Anaemia | 109.27 | 13.47 | 741 | 81189 | 251715 | 50271479 |
Recall phenomenon | 108.89 | 13.47 | 39 | 81891 | 517 | 50522677 |
White blood cell count decreased | 108.77 | 13.47 | 425 | 81505 | 116297 | 50406897 |
Musculoskeletal stiffness | 105.59 | 13.47 | 38 | 81892 | 128443 | 50394751 |
Dysgeusia | 104.75 | 13.47 | 209 | 81721 | 38707 | 50484487 |
Epistaxis | 100.29 | 13.47 | 278 | 81652 | 63676 | 50459518 |
Wound | 100.25 | 13.47 | 24 | 81906 | 105770 | 50417424 |
Product use issue | 99.93 | 13.47 | 59 | 81871 | 149416 | 50373778 |
Glossodynia | 98.74 | 13.47 | 32 | 81898 | 115537 | 50407657 |
Paronychia | 97.06 | 13.47 | 71 | 81859 | 4493 | 50518701 |
Lacrimation increased | 96.37 | 13.47 | 128 | 81802 | 16864 | 50506330 |
Biopsy lung abnormal | 95.41 | 13.47 | 26 | 81904 | 126 | 50523068 |
Overdose | 93.75 | 13.47 | 23 | 81907 | 99704 | 50423490 |
Dehydration | 93.20 | 13.47 | 490 | 81440 | 151959 | 50371235 |
Capillary leak syndrome | 92.76 | 13.47 | 50 | 81880 | 1840 | 50521354 |
Pain | 92.34 | 13.47 | 555 | 81375 | 578348 | 49944846 |
Metastases to pleura | 91.68 | 13.47 | 44 | 81886 | 1262 | 50521932 |
Thrombocytopenia | 88.34 | 13.47 | 425 | 81505 | 127248 | 50395946 |
Swelling | 86.84 | 13.47 | 119 | 81811 | 200753 | 50322441 |
Hepatic enzyme increased | 86.63 | 13.47 | 58 | 81872 | 137322 | 50385872 |
Lymphangiosis carcinomatosa | 86.11 | 13.47 | 41 | 81889 | 1155 | 50522039 |
Contusion | 85.89 | 13.47 | 37 | 81893 | 112146 | 50411048 |
Hypokalaemia | 85.71 | 13.47 | 325 | 81605 | 87667 | 50435527 |
Headache | 84.78 | 13.47 | 478 | 81452 | 506057 | 50017137 |
Injection site erythema | 83.99 | 13.47 | 11 | 81919 | 74925 | 50448269 |
Pneumonitis | 83.67 | 13.47 | 162 | 81768 | 29348 | 50493846 |
Drug abuse | 83.52 | 13.47 | 3 | 81927 | 59843 | 50463351 |
Organising pneumonia | 83.30 | 13.47 | 66 | 81864 | 4708 | 50518486 |
Exposure during pregnancy | 79.15 | 13.47 | 49 | 81881 | 120966 | 50402228 |
Radiation skin injury | 79.14 | 13.47 | 35 | 81895 | 828 | 50522366 |
Dermatitis | 78.74 | 13.47 | 106 | 81824 | 14145 | 50509049 |
Acute promyelocytic leukaemia | 75.14 | 13.47 | 34 | 81896 | 850 | 50522344 |
Myalgia | 74.86 | 13.47 | 398 | 81532 | 123921 | 50399273 |
Myositis | 73.88 | 13.47 | 77 | 81853 | 7843 | 50515351 |
Disease recurrence | 71.90 | 13.47 | 122 | 81808 | 19959 | 50503235 |
Febrile bone marrow aplasia | 71.13 | 13.47 | 68 | 81862 | 6243 | 50516951 |
Nail discolouration | 69.92 | 13.47 | 45 | 81885 | 2309 | 50520885 |
Metastases to spine | 69.34 | 13.47 | 48 | 81882 | 2783 | 50520411 |
Hospitalisation | 69.29 | 13.47 | 13 | 81917 | 67924 | 50455270 |
Helicobacter infection | 67.64 | 13.47 | 3 | 81927 | 49699 | 50473495 |
Arthritis | 67.34 | 13.47 | 28 | 81902 | 86693 | 50436501 |
Vascular device infection | 66.79 | 13.47 | 56 | 81874 | 4328 | 50518866 |
Osteoarthritis | 66.10 | 13.47 | 15 | 81915 | 68591 | 50454603 |
Multifocal micronodular pneumocyte hyperplasia | 64.82 | 13.47 | 17 | 81913 | 69 | 50523125 |
Bronchial polyp | 64.82 | 13.47 | 17 | 81913 | 69 | 50523125 |
Metastases to peritoneum | 64.65 | 13.47 | 46 | 81884 | 2787 | 50520407 |
Myocardial infarction | 64.05 | 13.47 | 32 | 81898 | 88995 | 50434199 |
Injury | 63.30 | 13.47 | 4 | 81926 | 48921 | 50474273 |
Large intestine perforation | 63.09 | 13.47 | 69 | 81861 | 7425 | 50515769 |
Nail dystrophy | 62.07 | 13.47 | 29 | 81901 | 782 | 50522412 |
Pericarditis | 61.75 | 13.47 | 25 | 81905 | 78664 | 50444530 |
Cerebrovascular accident | 60.99 | 13.47 | 39 | 81891 | 94641 | 50428553 |
Feeling abnormal | 60.86 | 13.47 | 68 | 81862 | 125424 | 50397770 |
Drug intolerance | 60.64 | 13.47 | 169 | 81761 | 218935 | 50304259 |
Ascites | 60.32 | 13.47 | 160 | 81770 | 35701 | 50487493 |
Pseudocirrhosis | 59.22 | 13.47 | 26 | 81904 | 604 | 50522590 |
Cardiomyopathy | 58.88 | 13.47 | 97 | 81833 | 15489 | 50507705 |
Inappropriate schedule of product administration | 57.72 | 13.47 | 22 | 81908 | 71809 | 50451385 |
Loss of personal independence in daily activities | 57.05 | 13.47 | 21 | 81909 | 70029 | 50453165 |
Device related thrombosis | 57.04 | 13.47 | 32 | 81898 | 1275 | 50521919 |
Suicide attempt | 57.00 | 13.47 | 8 | 81922 | 51724 | 50471470 |
Congestive cardiomyopathy | 55.74 | 13.47 | 56 | 81874 | 5462 | 50517732 |
Blood cholesterol increased | 55.38 | 13.47 | 11 | 81919 | 55204 | 50467990 |
Injection site swelling | 55.31 | 13.47 | 3 | 81927 | 41770 | 50481424 |
Drug interaction | 55.21 | 13.47 | 154 | 81776 | 199467 | 50323727 |
Injection site reaction | 54.51 | 13.47 | 8 | 81922 | 50024 | 50473170 |
Depression | 54.07 | 13.47 | 117 | 81813 | 165306 | 50357888 |
Constipation | 53.19 | 13.47 | 496 | 81434 | 185212 | 50337982 |
Dermatomyositis | 51.43 | 13.47 | 36 | 81894 | 2125 | 50521069 |
Hepatic function abnormal | 51.15 | 13.47 | 142 | 81788 | 32539 | 50490655 |
Enterocolitis infectious | 50.80 | 13.47 | 31 | 81899 | 1447 | 50521747 |
Periarticular thenar erythema with onycholysis | 50.70 | 13.47 | 11 | 81919 | 14 | 50523180 |
Injection site pruritus | 50.27 | 13.47 | 4 | 81926 | 40407 | 50482787 |
Mobility decreased | 50.04 | 13.47 | 34 | 81896 | 79914 | 50443280 |
Incorrect dose administered | 49.93 | 13.47 | 9 | 81921 | 48405 | 50474789 |
Migraine | 49.88 | 13.47 | 30 | 81900 | 75250 | 50447944 |
Gastrointestinal necrosis | 49.85 | 13.47 | 38 | 81892 | 2560 | 50520634 |
Adverse drug reaction | 49.48 | 13.47 | 14 | 81916 | 55208 | 50467986 |
Enterocolitis | 49.36 | 13.47 | 57 | 81873 | 6510 | 50516684 |
Psoriasis | 49.33 | 13.47 | 25 | 81905 | 68975 | 50454219 |
Lumbosacral radiculoplexus neuropathy | 48.34 | 13.47 | 11 | 81919 | 20 | 50523174 |
Duodenal ulcer perforation | 48.09 | 13.47 | 8 | 81922 | 45603 | 50477591 |
Irritable bowel syndrome | 48.07 | 13.47 | 12 | 81918 | 51429 | 50471765 |
Therapy partial responder | 47.52 | 13.47 | 56 | 81874 | 6535 | 50516659 |
Performance status decreased | 47.00 | 13.47 | 40 | 81890 | 3155 | 50520039 |
Metastases to meninges | 46.83 | 13.47 | 33 | 81897 | 1969 | 50521225 |
Dermatitis acneiform | 46.26 | 13.47 | 44 | 81886 | 4013 | 50519181 |
Influenza | 46.22 | 13.47 | 46 | 81884 | 89492 | 50433702 |
Discomfort | 45.99 | 13.47 | 65 | 81865 | 108315 | 50414879 |
Ventricular hypokinesia | 45.07 | 13.47 | 43 | 81887 | 3937 | 50519257 |
Asthma | 44.86 | 13.47 | 47 | 81883 | 89290 | 50433904 |
Asthenia | 44.71 | 13.47 | 745 | 81185 | 318297 | 50204897 |
Cystoid macular oedema | 44.68 | 13.47 | 28 | 81902 | 1371 | 50521823 |
Dyspnoea | 44.47 | 13.47 | 1180 | 80750 | 546428 | 49976766 |
Tonsillar disorder | 44.27 | 13.47 | 25 | 81905 | 1009 | 50522185 |
Erysipelas | 44.13 | 13.47 | 54 | 81876 | 6554 | 50516640 |
Device related infection | 43.85 | 13.47 | 101 | 81829 | 20634 | 50502560 |
Hot flush | 42.86 | 13.47 | 163 | 81767 | 44006 | 50479188 |
Cellulitis | 42.81 | 13.47 | 227 | 81703 | 70571 | 50452623 |
Alopecia totalis | 42.76 | 13.47 | 17 | 81913 | 305 | 50522889 |
Cardiac failure | 42.74 | 13.47 | 239 | 81691 | 75801 | 50447393 |
Blood lactate dehydrogenase increased | 42.16 | 13.47 | 96 | 81834 | 19466 | 50503728 |
Blood uric acid decreased | 41.96 | 13.47 | 21 | 81909 | 661 | 50522533 |
Onychalgia | 41.74 | 13.47 | 22 | 81908 | 773 | 50522421 |
Onychomadesis | 41.56 | 13.47 | 39 | 81891 | 3497 | 50519697 |
Suicidal ideation | 41.22 | 13.47 | 19 | 81911 | 55366 | 50467828 |
Ejection fraction | 40.82 | 13.47 | 25 | 81905 | 1175 | 50522019 |
Nasal congestion | 40.50 | 13.47 | 16 | 81914 | 51104 | 50472090 |
Alopecia | 39.92 | 13.47 | 587 | 81343 | 244460 | 50278734 |
Pericardial effusion | 39.86 | 13.47 | 111 | 81819 | 25478 | 50497716 |
Metastases to the mediastinum | 39.71 | 13.47 | 18 | 81912 | 452 | 50522742 |
Cardiac dysfunction | 39.70 | 13.47 | 28 | 81902 | 1673 | 50521521 |
Osteonecrosis of jaw | 39.27 | 13.47 | 129 | 81801 | 32397 | 50490797 |
Plasma cell myeloma | 39.24 | 13.47 | 3 | 81927 | 31319 | 50491875 |
Metastases to adrenals | 38.71 | 13.47 | 20 | 81910 | 674 | 50522520 |
Electrocardiogram QT prolonged | 38.30 | 13.47 | 18 | 81912 | 51868 | 50471326 |
Odynophagia | 38.26 | 13.47 | 50 | 81880 | 6482 | 50516712 |
Sedation | 38.16 | 13.47 | 3 | 81927 | 30607 | 50492587 |
Fatigue | 38.08 | 13.47 | 1451 | 80479 | 706150 | 49817044 |
Acute leukaemia | 38.02 | 13.47 | 23 | 81907 | 1057 | 50522137 |
Myelodysplastic syndrome | 38.01 | 13.47 | 79 | 81851 | 15053 | 50508141 |
Hallucination | 37.96 | 13.47 | 14 | 81916 | 46643 | 50476551 |
Hyperfibrinogenaemia | 37.75 | 13.47 | 9 | 81921 | 22 | 50523172 |
Computerised tomogram thorax abnormal | 37.56 | 13.47 | 25 | 81905 | 1358 | 50521836 |
Nasopharyngitis | 37.26 | 13.47 | 173 | 81757 | 192754 | 50330440 |
Impaired healing | 37.01 | 13.47 | 35 | 81895 | 69751 | 50453443 |
Bradycardia | 36.96 | 13.47 | 30 | 81900 | 64396 | 50458798 |
Nephrolithiasis | 36.76 | 13.47 | 6 | 81924 | 34687 | 50488507 |
Back pain | 36.59 | 13.47 | 529 | 81401 | 219501 | 50303693 |
Mastectomy | 36.19 | 13.47 | 25 | 81905 | 1444 | 50521750 |
Invasive ductal breast carcinoma | 35.74 | 13.47 | 46 | 81884 | 5875 | 50517319 |
Hypocalcaemia | 35.71 | 13.47 | 110 | 81820 | 26706 | 50496488 |
Obstructive shock | 35.70 | 13.47 | 9 | 81921 | 30 | 50523164 |
Cataract | 35.55 | 13.47 | 16 | 81914 | 47284 | 50475910 |
Excessive eye blinking | 35.52 | 13.47 | 21 | 81909 | 925 | 50522269 |
Purtscher retinopathy | 35.50 | 13.47 | 7 | 81923 | 3 | 50523191 |
Blood creatinine decreased | 35.42 | 13.47 | 42 | 81888 | 4934 | 50518260 |
Eosinophil percentage increased | 35.27 | 13.47 | 21 | 81909 | 937 | 50522257 |
Dacryostenosis acquired | 35.06 | 13.47 | 17 | 81913 | 499 | 50522695 |
Sepsis | 35.05 | 13.47 | 349 | 81581 | 132576 | 50390618 |
Carotidynia | 34.89 | 13.47 | 12 | 81918 | 140 | 50523054 |
COVID-19 | 34.73 | 13.47 | 16 | 81914 | 46646 | 50476548 |
Hypoglycaemia | 34.59 | 13.47 | 22 | 81908 | 53559 | 50469635 |
Arthralgia | 34.32 | 13.47 | 502 | 81428 | 438200 | 50084994 |
Breast pain | 34.12 | 13.47 | 51 | 81879 | 7493 | 50515701 |
Unevaluable event | 33.97 | 13.47 | 16 | 81914 | 46050 | 50477144 |
Therapeutic product effect incomplete | 33.97 | 13.47 | 60 | 81870 | 91455 | 50431739 |
Pregnancy | 33.97 | 13.47 | 4 | 81926 | 29573 | 50493621 |
Paraesthesia | 33.81 | 13.47 | 320 | 81610 | 119923 | 50403271 |
Bronchitis | 33.74 | 13.47 | 74 | 81856 | 104085 | 50419109 |
Abortion spontaneous | 33.21 | 13.47 | 13 | 81917 | 41759 | 50481435 |
Pulmonary mass | 33.03 | 13.47 | 85 | 81845 | 18620 | 50504574 |
Cystitis noninfective | 33.02 | 13.47 | 19 | 81911 | 795 | 50522399 |
Chest discomfort | 33 | 13.47 | 260 | 81670 | 92462 | 50430732 |
Intentional product use issue | 32.76 | 13.47 | 46 | 81884 | 76872 | 50446322 |
Anxiety | 32.69 | 13.47 | 162 | 81768 | 177444 | 50345750 |
Intestinal ischaemia | 32.46 | 13.47 | 47 | 81883 | 6710 | 50516484 |
Tumour embolism | 32.40 | 13.47 | 11 | 81919 | 123 | 50523071 |
EGFR gene mutation | 32.26 | 13.47 | 13 | 81917 | 242 | 50522952 |
Systemic scleroderma | 32.07 | 13.47 | 19 | 81911 | 840 | 50522354 |
Intentional product misuse | 31.84 | 13.47 | 18 | 81912 | 46716 | 50476478 |
Coronary artery disease | 31.82 | 13.47 | 5 | 81925 | 29721 | 50493473 |
International normalised ratio increased | 31.80 | 13.47 | 15 | 81915 | 43137 | 50480057 |
Radiation necrosis | 31.74 | 13.47 | 14 | 81916 | 329 | 50522865 |
Mucosal infection | 31.70 | 13.47 | 11 | 81919 | 132 | 50523062 |
Nephritis bacterial | 31.66 | 13.47 | 8 | 81922 | 27 | 50523167 |
Osteolysis | 31.60 | 13.47 | 29 | 81901 | 2528 | 50520666 |
Gas gangrene | 31.50 | 13.47 | 10 | 81920 | 89 | 50523105 |
Urticaria | 31.48 | 13.47 | 106 | 81824 | 129455 | 50393739 |
Therapy cessation | 31.20 | 13.47 | 3 | 81927 | 26008 | 50497186 |
Ear infection | 31.13 | 13.47 | 3 | 81927 | 25967 | 50497227 |
Wheezing | 30.75 | 13.47 | 33 | 81897 | 62014 | 50461180 |
Gait inability | 30.31 | 13.47 | 11 | 81919 | 37016 | 50486178 |
Type 2 diabetes mellitus | 30.27 | 13.47 | 9 | 81921 | 34366 | 50488828 |
Swollen tongue | 30.23 | 13.47 | 5 | 81925 | 28625 | 50494569 |
Death | 30.12 | 13.47 | 714 | 81216 | 324665 | 50198529 |
Blood glucose increased | 30.03 | 13.47 | 43 | 81887 | 71281 | 50451913 |
Coma | 29.60 | 13.47 | 29 | 81901 | 56850 | 50466344 |
Nail infection | 29.55 | 13.47 | 25 | 81905 | 1956 | 50521238 |
Gastric disorder | 29.39 | 13.47 | 6 | 81924 | 29542 | 50493652 |
Tremor | 29.30 | 13.47 | 92 | 81838 | 114811 | 50408383 |
Gait disturbance | 29.25 | 13.47 | 134 | 81796 | 149871 | 50373323 |
Drug resistance | 29.21 | 13.47 | 82 | 81848 | 18907 | 50504287 |
Medication error | 29.09 | 13.47 | 11 | 81919 | 36093 | 50487101 |
Hyperpyrexia | 29.08 | 13.47 | 30 | 81900 | 3019 | 50520175 |
Barotrauma | 28.82 | 13.47 | 11 | 81919 | 176 | 50523018 |
Hepatic lesion | 28.81 | 13.47 | 34 | 81896 | 3974 | 50519220 |
Road traffic accident | 28.71 | 13.47 | 3 | 81927 | 24349 | 50498845 |
Vascular fragility | 28.67 | 13.47 | 10 | 81920 | 122 | 50523072 |
Foetal exposure during pregnancy | 28.40 | 13.47 | 5 | 81925 | 27354 | 50495840 |
Pruritus | 28.30 | 13.47 | 308 | 81622 | 283260 | 50239934 |
Hypertransaminasaemia | 28.25 | 13.47 | 32 | 81898 | 3579 | 50519615 |
Nasal disorder | 28.18 | 13.47 | 26 | 81904 | 2282 | 50520912 |
Agitation | 28.04 | 13.47 | 27 | 81903 | 53357 | 50469837 |
Malignant pleural effusion | 27.97 | 13.47 | 26 | 81904 | 2304 | 50520890 |
Granulocyte count decreased | 27.95 | 13.47 | 17 | 81913 | 789 | 50522405 |
Vessel puncture site bruise | 27.91 | 13.47 | 13 | 81917 | 348 | 50522846 |
Vein discolouration | 27.38 | 13.47 | 11 | 81919 | 203 | 50522991 |
Asthenopia | 27.35 | 13.47 | 24 | 81906 | 1973 | 50521221 |
Metastases to chest wall | 27.31 | 13.47 | 14 | 81916 | 464 | 50522730 |
Scleroderma renal crisis | 27.28 | 13.47 | 12 | 81918 | 280 | 50522914 |
Metastatic neoplasm | 27.24 | 13.47 | 32 | 81898 | 3722 | 50519472 |
Basal cell carcinoma | 27.22 | 13.47 | 3 | 81927 | 23353 | 50499841 |
Lactic acidosis | 27.15 | 13.47 | 10 | 81920 | 33345 | 50489849 |
Vulvovaginal dryness | 27.12 | 13.47 | 25 | 81905 | 2192 | 50521002 |
Systolic dysfunction | 27.08 | 13.47 | 21 | 81909 | 1451 | 50521743 |
Dyskinesia | 27.01 | 13.47 | 6 | 81924 | 27855 | 50495339 |
Autonomic neuropathy | 26.76 | 13.47 | 18 | 81912 | 995 | 50522199 |
Dysuria | 26.67 | 13.47 | 104 | 81826 | 28400 | 50494794 |
Intestinal perforation | 26.66 | 13.47 | 55 | 81875 | 10424 | 50512770 |
Insomnia | 26.48 | 13.47 | 170 | 81760 | 174695 | 50348499 |
Tongue coated | 26.43 | 13.47 | 19 | 81911 | 1170 | 50522024 |
Alanine aminotransferase increased | 26.26 | 13.47 | 238 | 81692 | 88121 | 50435073 |
Mastitis | 25.90 | 13.47 | 25 | 81905 | 2322 | 50520872 |
General physical health deterioration | 25.89 | 13.47 | 348 | 81582 | 142086 | 50381108 |
Irritability | 25.85 | 13.47 | 7 | 81923 | 28419 | 50494775 |
Thrombotic microangiopathy | 25.82 | 13.47 | 49 | 81881 | 8742 | 50514452 |
Toxicity to various agents | 25.77 | 13.47 | 220 | 81710 | 212279 | 50310915 |
Full blood count decreased | 25.72 | 13.47 | 3 | 81927 | 22343 | 50500851 |
Osteoporosis | 25.61 | 13.47 | 21 | 81909 | 44858 | 50478336 |
Adverse event | 25.57 | 13.47 | 20 | 81910 | 43743 | 50479451 |
Toxic optic neuropathy | 25.54 | 13.47 | 10 | 81920 | 172 | 50523022 |
Bursitis | 25.40 | 13.47 | 3 | 81927 | 22132 | 50501062 |
Subclavian vein thrombosis | 25.40 | 13.47 | 22 | 81908 | 1777 | 50521417 |
PIK3CA-activated mutation | 25.34 | 13.47 | 16 | 81914 | 794 | 50522400 |
Vascular pain | 25.22 | 13.47 | 15 | 81915 | 668 | 50522526 |
Hepatotoxicity | 25.20 | 13.47 | 99 | 81831 | 27127 | 50496067 |
Perforation | 25.16 | 13.47 | 17 | 81913 | 947 | 50522247 |
Clostridium bacteraemia | 25.07 | 13.47 | 10 | 81920 | 181 | 50523013 |
Abdominal pain | 24.86 | 13.47 | 528 | 81402 | 235700 | 50287494 |
Sclerema | 24.79 | 13.47 | 5 | 81925 | 3 | 50523191 |
Nervousness | 24.79 | 13.47 | 7 | 81923 | 27644 | 50495550 |
Biliary sepsis | 24.63 | 13.47 | 16 | 81914 | 834 | 50522360 |
Depressed level of consciousness | 24.25 | 13.47 | 29 | 81901 | 51924 | 50471270 |
Injection site haemorrhage | 24.23 | 13.47 | 3 | 81927 | 21343 | 50501851 |
Retinal toxicity | 24.18 | 13.47 | 18 | 81912 | 1170 | 50522024 |
Troponin I increased | 24.10 | 13.47 | 22 | 81908 | 1904 | 50521290 |
Oral candidiasis | 24.04 | 13.47 | 71 | 81859 | 16844 | 50506350 |
Nail bed bleeding | 23.98 | 13.47 | 11 | 81919 | 284 | 50522910 |
Palmar erythema | 23.88 | 13.47 | 20 | 81910 | 1543 | 50521651 |
Recurrent cancer | 23.83 | 13.47 | 21 | 81909 | 1736 | 50521458 |
Folate deficiency | 23.82 | 13.47 | 22 | 81908 | 1933 | 50521261 |
Acoustic stimulation tests abnormal | 23.68 | 13.47 | 8 | 81922 | 88 | 50523106 |
Axillary pain | 23.65 | 13.47 | 20 | 81910 | 1564 | 50521630 |
Septic shock | 23.55 | 13.47 | 166 | 81764 | 57009 | 50466185 |
Metastases to thorax | 23.53 | 13.47 | 10 | 81920 | 214 | 50522980 |
Menopausal disorder | 23.52 | 13.47 | 7 | 81923 | 49 | 50523145 |
Chronic kidney disease | 23.46 | 13.47 | 18 | 81912 | 39753 | 50483441 |
Pneumocystis jirovecii pneumonia | 23.22 | 13.47 | 64 | 81866 | 14599 | 50508595 |
Metastases to soft tissue | 23.19 | 13.47 | 9 | 81921 | 151 | 50523043 |
Portal hypertension | 23.11 | 13.47 | 28 | 81902 | 3364 | 50519830 |
Pancreatitis | 23.03 | 13.47 | 21 | 81909 | 42593 | 50480601 |
Balance disorder | 22.98 | 13.47 | 50 | 81880 | 70540 | 50452654 |
Multiple sclerosis | 22.97 | 13.47 | 3 | 81927 | 20490 | 50502704 |
Treatment noncompliance | 22.97 | 13.47 | 10 | 81920 | 30140 | 50493054 |
Gamma-glutamyltransferase increased | 22.95 | 13.47 | 102 | 81828 | 29521 | 50493673 |
Ovarian necrosis | 22.95 | 13.47 | 6 | 81924 | 24 | 50523170 |
Left ventricular dilatation | 22.91 | 13.47 | 12 | 81918 | 416 | 50522778 |
Therapy interrupted | 22.47 | 13.47 | 3 | 81927 | 20149 | 50503045 |
Foot fracture | 22.38 | 13.47 | 3 | 81927 | 20088 | 50503106 |
Choroidal effusion | 22.25 | 13.47 | 12 | 81918 | 442 | 50522752 |
Metastases to ovary | 22.19 | 13.47 | 11 | 81919 | 339 | 50522855 |
Femur fracture | 22.04 | 13.47 | 17 | 81913 | 37447 | 50485747 |
Red blood cell sedimentation rate increased | 22.03 | 13.47 | 10 | 81920 | 29406 | 50493788 |
Peripheral swelling | 22.03 | 13.47 | 220 | 81710 | 205716 | 50317478 |
Panophthalmitis | 21.98 | 13.47 | 7 | 81923 | 63 | 50523131 |
Embolism | 21.92 | 13.47 | 40 | 81890 | 6928 | 50516266 |
Bone marrow infiltration | 21.91 | 13.47 | 12 | 81918 | 456 | 50522738 |
Osteitis condensans | 21.70 | 13.47 | 6 | 81924 | 31 | 50523163 |
Accidental overdose | 21.56 | 13.47 | 3 | 81927 | 19530 | 50503664 |
Metastases to nervous system | 21.54 | 13.47 | 6 | 81924 | 32 | 50523162 |
Herpes zoster | 21.54 | 13.47 | 52 | 81878 | 70734 | 50452460 |
Extravasation | 21.48 | 13.47 | 21 | 81909 | 1981 | 50521213 |
Post-traumatic pain | 21.45 | 13.47 | 11 | 81919 | 365 | 50522829 |
Hypertension | 21.21 | 13.47 | 229 | 81701 | 210974 | 50312220 |
Diabetes mellitus | 21.20 | 13.47 | 29 | 81901 | 49004 | 50474190 |
Blood alkaline phosphatase increased | 21.11 | 13.47 | 118 | 81812 | 37408 | 50485786 |
Vasculitis | 21.11 | 13.47 | 60 | 81870 | 13931 | 50509263 |
Acral peeling skin syndrome | 21.04 | 13.47 | 5 | 81925 | 12 | 50523182 |
Eastern Cooperative Oncology Group performance status worsened | 20.96 | 13.47 | 13 | 81917 | 625 | 50522569 |
Muscle necrosis | 20.90 | 13.47 | 12 | 81918 | 500 | 50522694 |
Product quality issue | 20.85 | 13.47 | 12 | 81918 | 30846 | 50492348 |
Generalised oedema | 20.83 | 13.47 | 59 | 81871 | 13672 | 50509522 |
Full blood count abnormal | 20.82 | 13.47 | 6 | 81924 | 23382 | 50499812 |
Eye pain | 20.79 | 13.47 | 10 | 81920 | 28439 | 50494755 |
White blood cell count abnormal | 20.74 | 13.47 | 34 | 81896 | 5406 | 50517788 |
Hip fracture | 20.73 | 13.47 | 8 | 81922 | 25923 | 50497271 |
Red cell distribution width increased | 20.70 | 13.47 | 44 | 81886 | 8515 | 50514679 |
Monocyte count decreased | 20.64 | 13.47 | 20 | 81910 | 1866 | 50521328 |
Blood creatine increased | 20.63 | 13.47 | 32 | 81898 | 4855 | 50518339 |
Skin laceration | 20.55 | 13.47 | 3 | 81927 | 18839 | 50504355 |
Joint injury | 20.51 | 13.47 | 5 | 81925 | 21784 | 50501410 |
HER2 positive breast cancer | 20.39 | 13.47 | 10 | 81920 | 301 | 50522893 |
Dizziness | 20.37 | 13.47 | 417 | 81513 | 345952 | 50177242 |
Neuromuscular toxicity | 20.36 | 13.47 | 8 | 81922 | 139 | 50523055 |
Lymphangitis | 20.31 | 13.47 | 14 | 81916 | 806 | 50522388 |
Epidermolysis | 20.31 | 13.47 | 9 | 81921 | 214 | 50522980 |
Hyperkalaemia | 20.23 | 13.47 | 29 | 81901 | 48060 | 50475134 |
Transaminases | 20.10 | 13.47 | 7 | 81923 | 85 | 50523109 |
Hypothalamo-pituitary disorder | 20.07 | 13.47 | 13 | 81917 | 674 | 50522520 |
Surgery | 20.05 | 13.47 | 12 | 81918 | 30193 | 50493001 |
Vision blurred | 20.03 | 13.47 | 63 | 81867 | 78584 | 50444610 |
Chromosomal mutation | 19.99 | 13.47 | 5 | 81925 | 16 | 50523178 |
Miller Fisher syndrome | 19.88 | 13.47 | 7 | 81923 | 88 | 50523106 |
Leukaemia cutis | 19.88 | 13.47 | 7 | 81923 | 88 | 50523106 |
Nail bed tenderness | 19.86 | 13.47 | 10 | 81920 | 319 | 50522875 |
Neck pain | 19.77 | 13.47 | 39 | 81891 | 57028 | 50466166 |
Hypoalbuminaemia | 19.72 | 13.47 | 47 | 81883 | 9813 | 50513381 |
Neutrophil count abnormal | 19.59 | 13.47 | 22 | 81908 | 2437 | 50520757 |
Aggression | 19.58 | 13.47 | 5 | 81925 | 21111 | 50502083 |
Dysarthria | 19.54 | 13.47 | 19 | 81911 | 37384 | 50485810 |
Phlebitis | 19.48 | 13.47 | 34 | 81896 | 5686 | 50517508 |
Chemical peritonitis | 19.46 | 13.47 | 7 | 81923 | 94 | 50523100 |
Hydrothorax | 19.34 | 13.47 | 13 | 81917 | 718 | 50522476 |
Seroma | 19.18 | 13.47 | 19 | 81911 | 1822 | 50521372 |
Paraparesis | 19.13 | 13.47 | 20 | 81910 | 2044 | 50521150 |
Malaise | 19.13 | 13.47 | 406 | 81524 | 335126 | 50188068 |
Ear pain | 19.11 | 13.47 | 11 | 81919 | 28272 | 50494922 |
Retinitis pigmentosa | 19.00 | 13.47 | 7 | 81923 | 101 | 50523093 |
Chronic obstructive pulmonary disease | 18.96 | 13.47 | 36 | 81894 | 53399 | 50469795 |
Paralysis recurrent laryngeal nerve | 18.94 | 13.47 | 6 | 81924 | 53 | 50523141 |
Congenital syphilitic osteochondritis | 18.93 | 13.47 | 5 | 81925 | 21 | 50523173 |
Lung infiltration | 18.82 | 13.47 | 56 | 81874 | 13337 | 50509857 |
Mucosal disorder | 18.71 | 13.47 | 19 | 81911 | 1876 | 50521318 |
Intervertebral disc protrusion | 18.58 | 13.47 | 5 | 81925 | 20388 | 50502806 |
Vulvitis | 18.53 | 13.47 | 9 | 81921 | 265 | 50522929 |
Tympanic membrane disorder | 18.50 | 13.47 | 8 | 81922 | 179 | 50523015 |
Blood pressure increased | 18.37 | 13.47 | 133 | 81797 | 132999 | 50390195 |
Merycism | 18.33 | 13.47 | 8 | 81922 | 183 | 50523011 |
Pneumonia aspiration | 18.33 | 13.47 | 14 | 81916 | 30990 | 50492204 |
Kidney infection | 18.25 | 13.47 | 4 | 81926 | 18742 | 50504452 |
Hyperchlorhydria | 18.24 | 13.47 | 17 | 81913 | 1511 | 50521683 |
Breast inflammation | 18.23 | 13.47 | 7 | 81923 | 114 | 50523080 |
Vaginal prolapse | 18.21 | 13.47 | 10 | 81920 | 382 | 50522812 |
Muscle spasticity | 18.14 | 13.47 | 3 | 81927 | 17181 | 50506013 |
Eosinophilia | 18.12 | 13.47 | 4 | 81926 | 18648 | 50504546 |
Renal failure | 18.07 | 13.47 | 100 | 81830 | 106533 | 50416661 |
Vulvovaginal candidiasis | 17.98 | 13.47 | 22 | 81908 | 2670 | 50520524 |
Drug ineffective for unapproved indication | 17.97 | 13.47 | 6 | 81924 | 21275 | 50501919 |
Cardiac arrest | 17.97 | 13.47 | 72 | 81858 | 83579 | 50439615 |
Lymphadenopathy | 17.96 | 13.47 | 104 | 81826 | 33395 | 50489799 |
Appendiceal abscess | 17.87 | 13.47 | 8 | 81922 | 195 | 50522999 |
Onychoclasis | 17.85 | 13.47 | 31 | 81899 | 5165 | 50518029 |
Chemotherapy | 17.85 | 13.47 | 16 | 81914 | 1353 | 50521841 |
Blood pressure fluctuation | 17.80 | 13.47 | 19 | 81911 | 35804 | 50487390 |
Vena cava thrombosis | 17.70 | 13.47 | 19 | 81911 | 2002 | 50521192 |
Meibomian gland dysfunction | 17.69 | 13.47 | 7 | 81923 | 124 | 50523070 |
Leukocytosis | 17.68 | 13.47 | 78 | 81852 | 22501 | 50500693 |
Cytotoxic oedema | 17.64 | 13.47 | 7 | 81923 | 125 | 50523069 |
Pulmonary toxicity | 17.58 | 13.47 | 32 | 81898 | 5530 | 50517664 |
Gallbladder disorder | 17.51 | 13.47 | 3 | 81927 | 16739 | 50506455 |
Pituitary tumour | 17.37 | 13.47 | 13 | 81917 | 852 | 50522342 |
Staphylococcal impetigo | 17.33 | 13.47 | 4 | 81926 | 8 | 50523186 |
Amnesia | 17.27 | 13.47 | 26 | 81904 | 42234 | 50480960 |
Gastrointestinal perforation | 17.26 | 13.47 | 23 | 81907 | 3038 | 50520156 |
Transient ischaemic attack | 17.25 | 13.47 | 16 | 81914 | 32194 | 50491000 |
Hypervolaemia | 17.11 | 13.47 | 10 | 81920 | 25489 | 50497705 |
Metastases to muscle | 17.10 | 13.47 | 7 | 81923 | 136 | 50523058 |
Metastases to uterus | 17.07 | 13.47 | 6 | 81924 | 75 | 50523119 |
Platelet count decreased | 17.03 | 13.47 | 243 | 81687 | 100483 | 50422711 |
Cough | 16.99 | 13.47 | 511 | 81419 | 240753 | 50282441 |
Foot deformity | 16.97 | 13.47 | 5 | 81925 | 19205 | 50503989 |
Emotional distress | 16.87 | 13.47 | 13 | 81917 | 28650 | 50494544 |
Gastritis | 16.78 | 13.47 | 101 | 81829 | 32882 | 50490312 |
Axillary vein thrombosis | 16.70 | 13.47 | 9 | 81921 | 331 | 50522863 |
Injection site rash | 16.69 | 13.47 | 3 | 81927 | 16174 | 50507020 |
Abdominal rigidity | 16.67 | 13.47 | 17 | 81913 | 1687 | 50521507 |
Clostridial infection | 16.67 | 13.47 | 26 | 81904 | 3964 | 50519230 |
Underdose | 16.64 | 13.47 | 6 | 81924 | 20272 | 50502922 |
Faeces discoloured | 16.62 | 13.47 | 3 | 81927 | 16121 | 50507073 |
Acute respiratory distress syndrome | 16.61 | 13.47 | 73 | 81857 | 21026 | 50502168 |
Dysaesthesia | 16.53 | 13.47 | 25 | 81905 | 3710 | 50519484 |
Hepatic failure | 16.52 | 13.47 | 99 | 81831 | 32184 | 50491010 |
No adverse event | 16.48 | 13.47 | 18 | 81912 | 33560 | 50489634 |
Hiccups | 16.38 | 13.47 | 17 | 81913 | 1722 | 50521472 |
Pneumothorax | 16.35 | 13.47 | 55 | 81875 | 13979 | 50509215 |
Acute interstitial pneumonitis | 16.29 | 13.47 | 11 | 81919 | 612 | 50522582 |
Labia enlarged | 16.28 | 13.47 | 3 | 81927 | 0 | 50523194 |
Astringent therapy | 16.28 | 13.47 | 3 | 81927 | 0 | 50523194 |
Chills | 16.25 | 13.47 | 233 | 81697 | 96454 | 50426740 |
Radiation pneumonitis | 16.22 | 13.47 | 15 | 81915 | 1320 | 50521874 |
Breast cancer | 16.21 | 13.47 | 122 | 81808 | 42768 | 50480426 |
Hormone receptor positive breast cancer | 16.21 | 13.47 | 10 | 81920 | 476 | 50522718 |
Muscle spasms | 16.10 | 13.47 | 128 | 81802 | 125425 | 50397769 |
Tumour marker increased | 16.01 | 13.47 | 25 | 81905 | 3815 | 50519379 |
Dandy-Walker syndrome | 15.96 | 13.47 | 6 | 81924 | 92 | 50523102 |
Herpes simplex sepsis | 15.90 | 13.47 | 5 | 81925 | 43 | 50523151 |
Rash follicular | 15.90 | 13.47 | 5 | 81925 | 43 | 50523151 |
Product administration error | 15.87 | 13.47 | 6 | 81924 | 19693 | 50503501 |
Coating in mouth | 15.85 | 13.47 | 7 | 81923 | 165 | 50523029 |
Pseudomembranous colitis | 15.82 | 13.47 | 21 | 81909 | 2764 | 50520430 |
Necrotising myositis | 15.76 | 13.47 | 9 | 81921 | 371 | 50522823 |
Laboratory test abnormal | 15.72 | 13.47 | 9 | 81921 | 23199 | 50499995 |
Nodular regenerative hyperplasia | 15.64 | 13.47 | 8 | 81922 | 264 | 50522930 |
Colitis ischaemic | 15.62 | 13.47 | 42 | 81888 | 9441 | 50513753 |
Retinal detachment | 15.57 | 13.47 | 29 | 81901 | 5100 | 50518094 |
Atypical pneumonia | 15.42 | 13.47 | 24 | 81906 | 3651 | 50519543 |
Vagus nerve disorder | 15.34 | 13.47 | 6 | 81924 | 103 | 50523091 |
Disorientation | 15.32 | 13.47 | 21 | 81909 | 35463 | 50487731 |
Cardio-respiratory arrest | 15.30 | 13.47 | 41 | 81889 | 53851 | 50469343 |
Acne pustular | 15.28 | 13.47 | 6 | 81924 | 104 | 50523090 |
Neoplasm recurrence | 15.24 | 13.47 | 19 | 81911 | 2350 | 50520844 |
Dermatitis bullous | 15.23 | 13.47 | 35 | 81895 | 7138 | 50516056 |
Pulmonary hypertension | 15.23 | 13.47 | 19 | 81911 | 33398 | 50489796 |
Anal erythema | 15.22 | 13.47 | 7 | 81923 | 182 | 50523012 |
Stress | 15.22 | 13.47 | 41 | 81889 | 53752 | 50469442 |
Granulocytopenia | 15.17 | 13.47 | 29 | 81901 | 5202 | 50517992 |
Pleural disorder | 15.11 | 13.47 | 10 | 81920 | 538 | 50522656 |
Limb injury | 14.98 | 13.47 | 7 | 81923 | 20243 | 50502951 |
Inflammatory carcinoma of the breast | 14.89 | 13.47 | 5 | 81925 | 54 | 50523140 |
Memory impairment | 14.81 | 13.47 | 72 | 81858 | 79288 | 50443906 |
Viral infection | 14.80 | 13.47 | 16 | 81914 | 29970 | 50493224 |
Sarcoidosis | 14.78 | 13.47 | 28 | 81902 | 4989 | 50518205 |
Arachnoid cyst | 14.74 | 13.47 | 7 | 81923 | 196 | 50522998 |
Monocytopenia | 14.56 | 13.47 | 5 | 81925 | 58 | 50523136 |
Seasonal allergy | 14.56 | 13.47 | 3 | 81927 | 14673 | 50508521 |
Hypomagnesaemia | 14.51 | 13.47 | 75 | 81855 | 23081 | 50500113 |
Left ventricular enlargement | 14.49 | 13.47 | 5 | 81925 | 59 | 50523135 |
Hydrocephalus | 14.45 | 13.47 | 27 | 81903 | 4761 | 50518433 |
Urogenital prolapse | 14.41 | 13.47 | 4 | 81926 | 21 | 50523173 |
Mouth ulceration | 14.38 | 13.47 | 86 | 81844 | 27938 | 50495256 |
Folliculitis | 14.30 | 13.47 | 26 | 81904 | 39199 | 50483995 |
Oral pain | 14.27 | 13.47 | 79 | 81851 | 24954 | 50498240 |
Upper limb fracture | 14.26 | 13.47 | 4 | 81926 | 15869 | 50507325 |
Cardiac tamponade | 14.21 | 13.47 | 25 | 81905 | 4207 | 50518987 |
Subretinal hyperreflective exudation | 14.21 | 13.47 | 3 | 81927 | 3 | 50523191 |
Delirium | 14.20 | 13.47 | 25 | 81905 | 38167 | 50485027 |
Fibrous histiocytoma | 14.19 | 13.47 | 9 | 81921 | 450 | 50522744 |
Borrelia infection | 14.18 | 13.47 | 6 | 81924 | 127 | 50523067 |
Pulmonary embolism | 14.00 | 13.47 | 237 | 81693 | 101467 | 50421727 |
Feeling hot | 13.98 | 13.47 | 110 | 81820 | 39092 | 50484102 |
Therapy responder | 13.96 | 13.47 | 8 | 81922 | 332 | 50522862 |
Liver function test abnormal | 13.94 | 13.47 | 32 | 81898 | 44307 | 50478887 |
Blood glucose decreased | 13.94 | 13.47 | 6 | 81924 | 18205 | 50504989 |
Pain in extremity | 13.88 | 13.47 | 336 | 81594 | 272529 | 50250665 |
Vein disorder | 13.85 | 13.47 | 25 | 81905 | 4294 | 50518900 |
Sleep disorder | 13.81 | 13.47 | 47 | 81883 | 57236 | 50465958 |
Iron deficiency anaemia | 13.78 | 13.47 | 5 | 81925 | 16829 | 50506365 |
Respiratory arrest | 13.74 | 13.47 | 17 | 81913 | 29992 | 50493202 |
Crying | 13.71 | 13.47 | 8 | 81922 | 20408 | 50502786 |
Device dislocation | 13.69 | 13.47 | 9 | 81921 | 21537 | 50501657 |
Clostridium difficile infection | 13.65 | 13.47 | 79 | 81851 | 25360 | 50497834 |
Therapy non-responder | 13.61 | 13.47 | 40 | 81890 | 50982 | 50472212 |
Peripheral motor neuropathy | 13.50 | 13.47 | 14 | 81916 | 1417 | 50521777 |
Acute respiratory failure | 13.50 | 13.47 | 16 | 81914 | 28766 | 50494428 |
Frequent bowel movements | 13.49 | 13.47 | 3 | 81927 | 13915 | 50509279 |
Peritoneal abscess | 13.49 | 13.47 | 6 | 81924 | 144 | 50523050 |
Oesophagitis | 13.48 | 13.47 | 50 | 81880 | 13333 | 50509861 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1198.65 | 15.55 | 881 | 36482 | 72978 | 29464186 |
Febrile neutropenia | 568.52 | 15.55 | 703 | 36660 | 111537 | 29425627 |
Osteonecrosis of jaw | 535.13 | 15.55 | 305 | 37058 | 16205 | 29520959 |
Prostatic specific antigen increased | 385.39 | 15.55 | 224 | 37139 | 12340 | 29524824 |
Metastases to bone | 356.35 | 15.55 | 196 | 37167 | 9702 | 29527462 |
Neutropenia | 339.76 | 15.55 | 601 | 36762 | 131110 | 29406054 |
Disease progression | 313.56 | 15.55 | 448 | 36915 | 81468 | 29455696 |
Diarrhoea | 301.41 | 15.55 | 1011 | 36352 | 331687 | 29205477 |
Mucosal inflammation | 190.75 | 15.55 | 217 | 37146 | 31378 | 29505786 |
Metastases to lymph nodes | 173.97 | 15.55 | 90 | 37273 | 3927 | 29533237 |
Hormone-refractory prostate cancer | 170.44 | 15.55 | 53 | 37310 | 576 | 29536588 |
Neutropenic sepsis | 165.17 | 15.55 | 129 | 37234 | 11598 | 29525566 |
Stomatitis | 164.29 | 15.55 | 218 | 37145 | 36895 | 29500269 |
Interstitial lung disease | 162.18 | 15.55 | 274 | 37089 | 57444 | 29479720 |
Neutrophil count decreased | 148.65 | 15.55 | 226 | 37137 | 43341 | 29493823 |
Prostate cancer metastatic | 148.13 | 15.55 | 87 | 37276 | 4879 | 29532285 |
Neoplasm progression | 126.37 | 15.55 | 136 | 37227 | 18476 | 29518688 |
Leukopenia | 125.50 | 15.55 | 239 | 37124 | 54964 | 29482200 |
Metastases to lung | 122.89 | 15.55 | 92 | 37271 | 7763 | 29529401 |
Alopecia | 120.11 | 15.55 | 134 | 37229 | 18950 | 29518214 |
Pneumonitis | 118.37 | 15.55 | 161 | 37202 | 27883 | 29509281 |
Palmar-plantar erythrodysaesthesia syndrome | 111.17 | 15.55 | 114 | 37249 | 14645 | 29522519 |
Onycholysis | 106.44 | 15.55 | 35 | 37328 | 461 | 29536703 |
Dehydration | 104.92 | 15.55 | 351 | 37012 | 114397 | 29422767 |
Metastases to liver | 103.04 | 15.55 | 99 | 37264 | 11757 | 29525407 |
Anaemia | 99.12 | 15.55 | 508 | 36855 | 200443 | 29336721 |
Skin toxicity | 91.76 | 15.55 | 58 | 37305 | 3713 | 29533451 |
Metastases to central nervous system | 90.90 | 15.55 | 74 | 37289 | 7057 | 29530107 |
Haematotoxicity | 88.53 | 15.55 | 71 | 37292 | 6628 | 29530536 |
Nausea | 84.54 | 15.55 | 639 | 36724 | 288616 | 29248548 |
Hypocalcaemia | 81.73 | 15.55 | 115 | 37248 | 20550 | 29516614 |
Drug interaction | 81.11 | 15.55 | 78 | 37285 | 197307 | 29339857 |
Portal venous gas | 80.82 | 15.55 | 26 | 37337 | 318 | 29536846 |
Product dose omission issue | 79.84 | 15.55 | 13 | 37350 | 96370 | 29440794 |
Fall | 76.35 | 15.55 | 67 | 37296 | 177111 | 29360053 |
Bone marrow failure | 75.27 | 15.55 | 129 | 37234 | 27320 | 29509844 |
Decreased appetite | 73.33 | 15.55 | 370 | 36993 | 144972 | 29392192 |
Bacterial translocation | 70.49 | 15.55 | 21 | 37342 | 195 | 29536969 |
Septic shock | 67.73 | 15.55 | 203 | 37160 | 62357 | 29474807 |
Prostate cancer | 66.12 | 15.55 | 117 | 37246 | 25410 | 29511754 |
White blood cell count decreased | 64.91 | 15.55 | 242 | 37121 | 83120 | 29454044 |
Peripheral sensory neuropathy | 64.10 | 15.55 | 56 | 37307 | 5883 | 29531281 |
Recall phenomenon | 62.36 | 15.55 | 24 | 37339 | 511 | 29536653 |
Neuropathy peripheral | 61.94 | 15.55 | 214 | 37149 | 70813 | 29466351 |
Bone pain | 60.45 | 15.55 | 94 | 37269 | 18358 | 29518806 |
Overdose | 59.30 | 15.55 | 14 | 37349 | 79805 | 29457359 |
Osteonecrosis | 57.60 | 15.55 | 78 | 37285 | 13441 | 29523723 |
Headache | 56.24 | 15.55 | 83 | 37280 | 173924 | 29363240 |
Vomiting | 55.27 | 15.55 | 457 | 36906 | 211803 | 29325361 |
Oesophageal fistula | 55.06 | 15.55 | 17 | 37346 | 180 | 29536984 |
Oesophagobronchial fistula | 54.35 | 15.55 | 16 | 37347 | 142 | 29537022 |
Tremor | 52.49 | 15.55 | 14 | 37349 | 73524 | 29463640 |
Nasopharyngitis | 51.80 | 15.55 | 7 | 37356 | 59658 | 29477506 |
Bone lesion | 49.87 | 15.55 | 35 | 37328 | 2669 | 29534495 |
Nail disorder | 49.31 | 15.55 | 30 | 37333 | 1794 | 29535370 |
Metastasis | 48.87 | 15.55 | 38 | 37325 | 3391 | 29533773 |
Pleural effusion | 48.84 | 15.55 | 200 | 37163 | 71708 | 29465456 |
Fatigue | 48.74 | 15.55 | 612 | 36751 | 316209 | 29220955 |
General physical health deterioration | 48.43 | 15.55 | 257 | 37106 | 102600 | 29434564 |
Colon cancer stage III | 48.19 | 15.55 | 14 | 37349 | 118 | 29537046 |
Polyneuropathy | 45.64 | 15.55 | 66 | 37297 | 12086 | 29525078 |
Reproductive toxicity | 44.85 | 15.55 | 9 | 37354 | 9 | 29537155 |
Urinary tract toxicity | 44.37 | 15.55 | 9 | 37354 | 10 | 29537154 |
Radiation skin injury | 43.82 | 15.55 | 20 | 37343 | 660 | 29536504 |
Agitation | 42.28 | 15.55 | 7 | 37356 | 51297 | 29485867 |
Onychomadesis | 42.18 | 15.55 | 18 | 37345 | 504 | 29536660 |
Neutropenic colitis | 41.68 | 15.55 | 30 | 37333 | 2381 | 29534783 |
Metastases to skin | 41.51 | 15.55 | 16 | 37347 | 342 | 29536822 |
Prostate cancer recurrent | 41.05 | 15.55 | 21 | 37342 | 894 | 29536270 |
Weight increased | 40.86 | 15.55 | 23 | 37340 | 76644 | 29460520 |
Pyrexia | 39.74 | 15.55 | 545 | 36818 | 287077 | 29250087 |
Rhabdomyolysis | 39.04 | 15.55 | 14 | 37349 | 60794 | 29476370 |
Insomnia | 38.85 | 15.55 | 33 | 37330 | 88728 | 29448436 |
Depression | 38.08 | 15.55 | 31 | 37332 | 85116 | 29452048 |
Cardiac failure congestive | 37.99 | 15.55 | 25 | 37338 | 76556 | 29460608 |
Disseminated intravascular coagulation | 37.56 | 15.55 | 80 | 37283 | 19900 | 29517264 |
Somnolence | 37.50 | 15.55 | 38 | 37325 | 93917 | 29443247 |
Pulmonary toxicity | 37.22 | 15.55 | 38 | 37325 | 4852 | 29532312 |
Pneumatosis intestinalis | 36.46 | 15.55 | 31 | 37332 | 3138 | 29534026 |
Dermatitis | 36.31 | 15.55 | 47 | 37316 | 7751 | 29529413 |
Gastrointestinal toxicity | 35.66 | 15.55 | 26 | 37337 | 2105 | 29535059 |
Gastric perforation | 35.07 | 15.55 | 26 | 37337 | 2160 | 29535004 |
Acute motor-sensory axonal neuropathy | 35.01 | 15.55 | 11 | 37352 | 124 | 29537040 |
Exposed bone in jaw | 34.03 | 15.55 | 22 | 37341 | 1464 | 29535700 |
Plasma cell myeloma | 33.07 | 15.55 | 4 | 37359 | 37111 | 29500053 |
Metastases to meninges | 33.04 | 15.55 | 20 | 37343 | 1185 | 29535979 |
Nail toxicity | 32.98 | 15.55 | 8 | 37355 | 30 | 29537134 |
Death | 32.83 | 15.55 | 610 | 36753 | 341474 | 29195690 |
Necrotising retinitis | 32.65 | 15.55 | 17 | 37346 | 751 | 29536413 |
Metastases to soft tissue | 32.44 | 15.55 | 12 | 37351 | 228 | 29536936 |
Carbohydrate antigen 15-3 increased | 31.73 | 15.55 | 9 | 37354 | 69 | 29537095 |
Pneumothorax | 31.61 | 15.55 | 65 | 37298 | 15777 | 29521387 |
Nail ridging | 31.46 | 15.55 | 8 | 37355 | 38 | 29537126 |
Musculoskeletal stiffness | 31.11 | 15.55 | 5 | 37358 | 37453 | 29499711 |
Hallucination | 30.99 | 15.55 | 9 | 37354 | 44703 | 29492461 |
Erythema | 30.95 | 15.55 | 182 | 37181 | 75424 | 29461740 |
Metastases to pleura | 30.91 | 15.55 | 13 | 37350 | 351 | 29536813 |
Myocardial infarction | 30.60 | 15.55 | 58 | 37305 | 110238 | 29426926 |
Second primary malignancy | 30.57 | 15.55 | 40 | 37323 | 6665 | 29530499 |
Drug hypersensitivity | 30.46 | 15.55 | 25 | 37338 | 68381 | 29468783 |
Blood pressure increased | 29.27 | 15.55 | 30 | 37333 | 73773 | 29463391 |
Intestinal ischaemia | 29.09 | 15.55 | 39 | 37324 | 6653 | 29530511 |
Atypical haemolytic uraemic syndrome | 28.86 | 15.55 | 10 | 37353 | 156 | 29537008 |
Drug ineffective | 28.77 | 15.55 | 307 | 37056 | 362863 | 29174301 |
Hypophagia | 28.76 | 15.55 | 74 | 37289 | 20798 | 29516366 |
Bone disorder | 28.73 | 15.55 | 36 | 37327 | 5747 | 29531417 |
Gastrointestinal ischaemia | 28.62 | 15.55 | 10 | 37353 | 160 | 29537004 |
Metastases to spine | 28.61 | 15.55 | 23 | 37340 | 2153 | 29535011 |
Eubacterium infection | 28.38 | 15.55 | 5 | 37358 | 0 | 29537164 |
Karnofsky scale worsened | 28.38 | 15.55 | 5 | 37358 | 0 | 29537164 |
Suicidal ideation | 28.02 | 15.55 | 5 | 37358 | 34711 | 29502453 |
Dizziness | 27.90 | 15.55 | 134 | 37229 | 189550 | 29347614 |
Joint swelling | 27.74 | 15.55 | 14 | 37349 | 49616 | 29487548 |
Injection site pain | 27.70 | 15.55 | 4 | 37359 | 32442 | 29504722 |
Cerebrovascular accident | 27.52 | 15.55 | 34 | 37329 | 76877 | 29460287 |
Inappropriate schedule of product administration | 27.27 | 15.55 | 11 | 37352 | 44461 | 29492703 |
Anxiety | 27.25 | 15.55 | 41 | 37322 | 85324 | 29451840 |
Urticaria | 26.89 | 15.55 | 18 | 37345 | 54642 | 29482522 |
Nicotinic acid deficiency | 26.88 | 15.55 | 8 | 37355 | 74 | 29537090 |
Mediastinitis | 26.71 | 15.55 | 14 | 37349 | 627 | 29536537 |
Muscle spasms | 26.33 | 15.55 | 26 | 37337 | 65056 | 29472108 |
Macroenzyme creatine kinase | 26.28 | 15.55 | 6 | 37357 | 16 | 29537148 |
Colitis | 26.21 | 15.55 | 93 | 37270 | 31155 | 29506009 |
Incorrect dose administered | 26.09 | 15.55 | 5 | 37358 | 32979 | 29504185 |
Carotid artery aneurysm | 26.02 | 15.55 | 7 | 37356 | 43 | 29537121 |
Hyponatraemia | 25.89 | 15.55 | 160 | 37203 | 67473 | 29469691 |
Dysphagia | 25.64 | 15.55 | 137 | 37226 | 54789 | 29482375 |
Hypophosphataemia | 25.43 | 15.55 | 40 | 37323 | 7884 | 29529280 |
Cholangitis sclerosing | 24.93 | 15.55 | 16 | 37347 | 1051 | 29536113 |
Pancreatitis viral | 24.92 | 15.55 | 5 | 37358 | 5 | 29537159 |
Tooth extraction | 24.28 | 15.55 | 28 | 37335 | 4101 | 29533063 |
Seizure | 24.08 | 15.55 | 51 | 37312 | 93072 | 29444092 |
Contusion | 23.99 | 15.55 | 5 | 37358 | 31090 | 29506074 |
Sinusitis | 23.64 | 15.55 | 7 | 37356 | 34343 | 29502821 |
Blood glucose increased | 23.36 | 15.55 | 24 | 37339 | 58960 | 29478204 |
Pharyngeal abscess | 23.26 | 15.55 | 11 | 37352 | 394 | 29536770 |
Flushing | 23.22 | 15.55 | 85 | 37278 | 28907 | 29508257 |
Rheumatoid arthritis | 23.16 | 15.55 | 6 | 37357 | 32146 | 29505018 |
Transdifferentiation of neoplasm | 22.94 | 15.55 | 7 | 37356 | 71 | 29537093 |
Chemotherapy | 22.80 | 15.55 | 12 | 37351 | 542 | 29536622 |
Hypokalaemia | 22.61 | 15.55 | 124 | 37239 | 50079 | 29487085 |
Hydronephrosis | 22.57 | 15.55 | 40 | 37323 | 8690 | 29528474 |
Paronychia | 22.57 | 15.55 | 23 | 37340 | 2930 | 29534234 |
Acute respiratory distress syndrome | 22.54 | 15.55 | 72 | 37291 | 22863 | 29514301 |
Tracheal fistula | 22.51 | 15.55 | 7 | 37356 | 76 | 29537088 |
Rash | 22.49 | 15.55 | 144 | 37219 | 189675 | 29347489 |
Therapy partial responder | 22.14 | 15.55 | 30 | 37333 | 5169 | 29531995 |
Tumour pain | 22.06 | 15.55 | 14 | 37349 | 902 | 29536262 |
Hospitalisation | 21.49 | 15.55 | 16 | 37347 | 45972 | 29491192 |
Tracheal stenosis | 21.48 | 15.55 | 8 | 37355 | 155 | 29537009 |
Bronchial fistula | 21.16 | 15.55 | 8 | 37355 | 162 | 29537002 |
Aorto-oesophageal fistula | 21.04 | 15.55 | 6 | 37357 | 47 | 29537117 |
Capillary leak syndrome | 20.68 | 15.55 | 18 | 37345 | 1881 | 29535283 |
Blood creatine phosphokinase increased | 20.51 | 15.55 | 13 | 37350 | 40631 | 29496533 |
Free prostate-specific antigen positive | 20.47 | 15.55 | 4 | 37359 | 3 | 29537161 |
Metastases to bladder | 20.40 | 15.55 | 6 | 37357 | 53 | 29537111 |
Gastrointestinal necrosis | 20.35 | 15.55 | 22 | 37341 | 3000 | 29534164 |
Trigeminal nerve paresis | 19.93 | 15.55 | 4 | 37359 | 4 | 29537160 |
Infusion site plaque | 19.93 | 15.55 | 4 | 37359 | 4 | 29537160 |
Metastases to peritoneum | 19.85 | 15.55 | 16 | 37347 | 1504 | 29535660 |
Feeling abnormal | 19.54 | 15.55 | 24 | 37339 | 54421 | 29482743 |
Scleroderma | 19.44 | 15.55 | 15 | 37348 | 1323 | 29535841 |
Abnormal behaviour | 19.40 | 15.55 | 3 | 37360 | 23124 | 29514040 |
Lacrimation increased | 19.38 | 15.55 | 33 | 37330 | 6947 | 29530217 |
Oesophagitis | 19.32 | 15.55 | 45 | 37318 | 11878 | 29525286 |
Periorbital disorder | 18.98 | 15.55 | 5 | 37358 | 28 | 29537136 |
Metastases to the mediastinum | 18.85 | 15.55 | 8 | 37355 | 221 | 29536943 |
Superior mesenteric artery syndrome | 18.75 | 15.55 | 6 | 37357 | 72 | 29537092 |
Cranial nerve disorder | 18.73 | 15.55 | 10 | 37353 | 465 | 29536699 |
Enteritis | 18.71 | 15.55 | 32 | 37331 | 6759 | 29530405 |
Hypovolaemic shock | 18.59 | 15.55 | 30 | 37333 | 6042 | 29531122 |
Aneurysm ruptured | 18.56 | 15.55 | 10 | 37353 | 474 | 29536690 |
Osteoradionecrosis | 18.53 | 15.55 | 6 | 37357 | 75 | 29537089 |
Irritability | 18.30 | 15.55 | 3 | 37360 | 22149 | 29515015 |
Oral candidiasis | 17.96 | 15.55 | 41 | 37322 | 10681 | 29526483 |
Memory impairment | 17.95 | 15.55 | 12 | 37351 | 36458 | 29500706 |
Acute interstitial pneumonitis | 17.93 | 15.55 | 9 | 37354 | 368 | 29536796 |
Bradycardia | 17.76 | 15.55 | 35 | 37328 | 65594 | 29471570 |
Neutropenic infection | 17.58 | 15.55 | 14 | 37349 | 1293 | 29535871 |
Disturbance in attention | 17.48 | 15.55 | 3 | 37360 | 21421 | 29515743 |
Agranulocytosis | 17.45 | 15.55 | 61 | 37302 | 20279 | 29516885 |
Oral pain | 17.18 | 15.55 | 37 | 37326 | 9270 | 29527894 |
Carotidynia | 17.03 | 15.55 | 3 | 37360 | 0 | 29537164 |
Hyperchromasia | 17.03 | 15.55 | 3 | 37360 | 0 | 29537164 |
Arthralgia | 16.99 | 15.55 | 105 | 37258 | 139512 | 29397652 |
Adenocarcinoma | 16.89 | 15.55 | 15 | 37348 | 1610 | 29535554 |
Pruritus | 16.89 | 15.55 | 83 | 37280 | 116766 | 29420398 |
Oesophageal perforation | 16.85 | 15.55 | 11 | 37352 | 744 | 29536420 |
Coma | 16.84 | 15.55 | 15 | 37348 | 39435 | 29497729 |
Retroperitoneal lymphadenopathy | 16.83 | 15.55 | 11 | 37352 | 746 | 29536418 |
Dacryostenosis acquired | 16.82 | 15.55 | 7 | 37356 | 184 | 29536980 |
Tracheo-oesophageal fistula | 16.81 | 15.55 | 9 | 37354 | 421 | 29536743 |
Thrombocytopenia | 16.74 | 15.55 | 251 | 37112 | 134572 | 29402592 |
PO2 increased | 16.65 | 15.55 | 10 | 37353 | 584 | 29536580 |
Traumatic lung injury | 16.65 | 15.55 | 13 | 37350 | 1167 | 29535997 |
International normalised ratio increased | 16.52 | 15.55 | 19 | 37344 | 44353 | 29492811 |
Portosplenomesenteric venous thrombosis | 16.49 | 15.55 | 4 | 37359 | 15 | 29537149 |
Vascular pseudoaneurysm | 16.41 | 15.55 | 16 | 37347 | 1933 | 29535231 |
Polyneuropathy in malignant disease | 16.37 | 15.55 | 6 | 37357 | 111 | 29537053 |
Enterovesical fistula | 16.33 | 15.55 | 10 | 37353 | 605 | 29536559 |
Psychotic disorder | 16.28 | 15.55 | 3 | 37360 | 20351 | 29516813 |
Nephrolithiasis | 15.97 | 15.55 | 6 | 37357 | 25328 | 29511836 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1659.70 | 13.20 | 1385 | 98844 | 111486 | 64287017 |
Febrile neutropenia | 1406.82 | 13.20 | 1590 | 98639 | 186067 | 64212436 |
Neutropenia | 1198.88 | 13.20 | 1658 | 98571 | 237966 | 64160537 |
Diarrhoea | 1076.62 | 13.20 | 2988 | 97241 | 719716 | 63678787 |
Palmar-plantar erythrodysaesthesia syndrome | 749.78 | 13.20 | 499 | 99730 | 28320 | 64370183 |
Disease progression | 738.11 | 13.20 | 1001 | 99228 | 140679 | 64257824 |
Metastases to bone | 720.40 | 13.20 | 429 | 99800 | 20006 | 64378497 |
Mucosal inflammation | 668.36 | 13.20 | 642 | 99587 | 61942 | 64336561 |
Neuropathy peripheral | 588.65 | 13.20 | 815 | 99414 | 116710 | 64281793 |
Myelosuppression | 547.09 | 13.20 | 382 | 99847 | 23448 | 64375055 |
Bone marrow failure | 532.95 | 13.20 | 503 | 99726 | 47449 | 64351054 |
Metastases to liver | 485.75 | 13.20 | 356 | 99873 | 23585 | 64374918 |
Metastases to lung | 415.57 | 13.20 | 272 | 99957 | 14992 | 64383511 |
Neutropenic sepsis | 396.89 | 13.20 | 312 | 99917 | 22960 | 64375543 |
Metastases to central nervous system | 386.31 | 13.20 | 251 | 99978 | 13661 | 64384842 |
Metastases to lymph nodes | 384.85 | 13.20 | 212 | 100017 | 8505 | 64389998 |
Osteonecrosis of jaw | 379.33 | 13.20 | 384 | 99845 | 39441 | 64359062 |
Ejection fraction decreased | 343.72 | 13.20 | 314 | 99915 | 28393 | 64370110 |
Neoplasm progression | 319.19 | 13.20 | 355 | 99874 | 40609 | 64357894 |
Stomatitis | 295.73 | 13.20 | 575 | 99654 | 109030 | 64289473 |
Fall | 281.02 | 13.20 | 149 | 100080 | 416677 | 63981826 |
Leukopenia | 279.08 | 13.20 | 536 | 99693 | 100706 | 64297797 |
Skin toxicity | 273.51 | 13.20 | 154 | 100075 | 6448 | 64392055 |
Polyneuropathy | 262.69 | 13.20 | 230 | 99999 | 19664 | 64378839 |
Agranulocytosis | 258.59 | 13.20 | 308 | 99921 | 37921 | 64360582 |
Neutrophil count decreased | 256.22 | 13.20 | 443 | 99786 | 76753 | 64321750 |
Interstitial lung disease | 249.46 | 13.20 | 501 | 99728 | 97231 | 64301272 |
Prostatic specific antigen increased | 245.52 | 13.20 | 159 | 100070 | 8601 | 64389902 |
Rheumatoid arthritis | 235.00 | 13.20 | 4 | 100225 | 164290 | 64234213 |
Drug ineffective | 233.92 | 13.20 | 610 | 99619 | 839637 | 63558866 |
Onycholysis | 216.40 | 13.20 | 85 | 100144 | 1541 | 64396962 |
Haematotoxicity | 213.62 | 13.20 | 170 | 100059 | 12726 | 64385777 |
Nausea | 212.97 | 13.20 | 2004 | 98225 | 783796 | 63614707 |
Decreased appetite | 208.96 | 13.20 | 928 | 99301 | 280361 | 64118142 |
Joint swelling | 195.85 | 13.20 | 47 | 100182 | 215335 | 64183168 |
Peripheral sensory neuropathy | 194.94 | 13.20 | 153 | 100076 | 11225 | 64387278 |
Alopecia areata | 186.36 | 13.20 | 75 | 100154 | 1453 | 64397050 |
Product dose omission issue | 186.13 | 13.20 | 38 | 100191 | 194709 | 64203794 |
Drug abuse | 182.32 | 13.20 | 5 | 100224 | 132369 | 64266134 |
Pleural effusion | 180.85 | 13.20 | 518 | 99711 | 126041 | 64272462 |
White blood cell count decreased | 178.17 | 13.20 | 595 | 99634 | 157242 | 64241261 |
Neutropenic colitis | 176.71 | 13.20 | 102 | 100127 | 4479 | 64394024 |
Bone pain | 176.45 | 13.20 | 287 | 99942 | 47285 | 64351218 |
Recall phenomenon | 171.45 | 13.20 | 63 | 100166 | 943 | 64397560 |
Madarosis | 168.19 | 13.20 | 79 | 100150 | 2251 | 64396252 |
Vomiting | 160.16 | 13.20 | 1428 | 98801 | 549689 | 63848814 |
Flushing | 157.96 | 13.20 | 366 | 99863 | 78282 | 64320221 |
Pneumonitis | 157.94 | 13.20 | 282 | 99947 | 50083 | 64348420 |
Colitis | 155.91 | 13.20 | 306 | 99923 | 58368 | 64340135 |
Alopecia | 155.59 | 13.20 | 588 | 99641 | 165102 | 64233401 |
Nail disorder | 152.14 | 13.20 | 118 | 100111 | 8506 | 64389997 |
Hair texture abnormal | 152.00 | 13.20 | 80 | 100149 | 2924 | 64395579 |
Metastasis | 151.37 | 13.20 | 100 | 100129 | 5595 | 64392908 |
Overdose | 148.64 | 13.20 | 33 | 100196 | 159533 | 64238970 |
Therapeutic product effect decreased | 146.52 | 13.20 | 8 | 100221 | 115343 | 64283160 |
Arthropathy | 145.91 | 13.20 | 11 | 100218 | 120956 | 64277547 |
Pyrexia | 142.50 | 13.20 | 1408 | 98821 | 557236 | 63841267 |
Drug interaction | 140.47 | 13.20 | 216 | 100013 | 361867 | 64036636 |
Metastases to skin | 139.11 | 13.20 | 60 | 100169 | 1392 | 64397111 |
Hair colour changes | 138.50 | 13.20 | 81 | 100148 | 3646 | 64394857 |
Somnolence | 138.16 | 13.20 | 72 | 100157 | 203573 | 64194930 |
Gastrointestinal toxicity | 135.54 | 13.20 | 91 | 100138 | 5231 | 64393272 |
Acute myeloid leukaemia | 135.03 | 13.20 | 189 | 100040 | 27274 | 64371229 |
Erythema | 133.32 | 13.20 | 610 | 99619 | 186460 | 64212043 |
Anaemia | 133.23 | 13.20 | 1025 | 99204 | 377655 | 64020848 |
Contraindicated product administered | 132.37 | 13.20 | 9 | 100220 | 107820 | 64290683 |
Sinusitis | 128.44 | 13.20 | 34 | 100195 | 145894 | 64252609 |
Cardiotoxicity | 128.08 | 13.20 | 115 | 100114 | 10159 | 64388344 |
Drug hypersensitivity | 127.81 | 13.20 | 109 | 100120 | 237706 | 64160797 |
Nail toxicity | 127.53 | 13.20 | 39 | 100190 | 317 | 64398186 |
Dehydration | 124.70 | 13.20 | 665 | 99564 | 216098 | 64182405 |
Second primary malignancy | 121.15 | 13.20 | 121 | 100108 | 12216 | 64386287 |
Aortitis | 120.47 | 13.20 | 50 | 100179 | 1051 | 64397452 |
Breast cancer recurrent | 120.03 | 13.20 | 65 | 100164 | 2518 | 64395985 |
Weight increased | 119.34 | 13.20 | 94 | 100135 | 213254 | 64185249 |
Injection site pain | 119.15 | 13.20 | 16 | 100213 | 111392 | 64287111 |
Capillary leak syndrome | 115.56 | 13.20 | 69 | 100160 | 3228 | 64395275 |
Myocardial infarction | 111.90 | 13.20 | 59 | 100170 | 165762 | 64232741 |
Confusional state | 109.87 | 13.20 | 147 | 100082 | 260997 | 64137506 |
Dermatitis | 108.52 | 13.20 | 137 | 100092 | 17892 | 64380611 |
Radiation skin injury | 108.20 | 13.20 | 49 | 100180 | 1281 | 64397222 |
Left ventricular dysfunction | 103.91 | 13.20 | 130 | 100099 | 16824 | 64381679 |
Musculoskeletal stiffness | 102.34 | 13.20 | 32 | 100197 | 123174 | 64275329 |
Breast cancer metastatic | 100.93 | 13.20 | 86 | 100143 | 7083 | 64391420 |
Paronychia | 97.84 | 13.20 | 81 | 100148 | 6411 | 64392092 |
Systemic lupus erythematosus | 96.67 | 13.20 | 6 | 100223 | 77606 | 64320897 |
Lacrimation increased | 95.81 | 13.20 | 130 | 100099 | 18216 | 64380287 |
Biopsy lung abnormal | 95.47 | 13.20 | 26 | 100203 | 132 | 64398371 |
Dysgeusia | 94.48 | 13.20 | 219 | 100010 | 46828 | 64351675 |
Condition aggravated | 93.72 | 13.20 | 283 | 99946 | 372143 | 64026360 |
Lymphoedema | 93.33 | 13.20 | 95 | 100134 | 9810 | 64388693 |
Fatigue | 90.40 | 13.20 | 1648 | 98581 | 747082 | 63651421 |
Headache | 90.22 | 13.20 | 470 | 99759 | 528997 | 63869506 |
Metastases to pleura | 88.60 | 13.20 | 42 | 100187 | 1222 | 64397281 |
Cerebrovascular accident | 88.41 | 13.20 | 52 | 100177 | 137531 | 64260972 |
Portal venous gas | 86.70 | 13.20 | 29 | 100200 | 323 | 64398180 |
Contusion | 83.84 | 13.20 | 36 | 100193 | 113929 | 64284574 |
Metastases to meninges | 83.60 | 13.20 | 53 | 100176 | 2762 | 64395741 |
Product use issue | 83.36 | 13.20 | 68 | 100161 | 151647 | 64246856 |
Pemphigus | 81.03 | 13.20 | 3 | 100226 | 60698 | 64337805 |
Suicide attempt | 78.84 | 13.20 | 9 | 100220 | 70998 | 64327505 |
Lymphangiosis carcinomatosa | 76.84 | 13.20 | 43 | 100186 | 1778 | 64396725 |
Skin exfoliation | 76.34 | 13.20 | 196 | 100033 | 44689 | 64353814 |
Depression | 76.21 | 13.20 | 104 | 100125 | 183187 | 64215316 |
Septic shock | 75.16 | 13.20 | 344 | 99885 | 105093 | 64293410 |
Hand deformity | 74.86 | 13.20 | 6 | 100223 | 62765 | 64335738 |
Acute promyelocytic leukaemia | 73.18 | 13.20 | 38 | 100191 | 1350 | 64397153 |
Abdominal discomfort | 72.29 | 13.20 | 107 | 100122 | 182215 | 64216288 |
Inappropriate schedule of product administration | 71.39 | 13.20 | 27 | 100202 | 92259 | 64306244 |
Myositis | 70.72 | 13.20 | 106 | 100123 | 16271 | 64382232 |
Hypocalcaemia | 70.67 | 13.20 | 182 | 100047 | 41571 | 64356932 |
Metastases to peritoneum | 70.23 | 13.20 | 52 | 100177 | 3495 | 64395008 |
Hypokalaemia | 70.01 | 13.20 | 374 | 99855 | 121529 | 64276974 |
Hormone-refractory prostate cancer | 69.75 | 13.20 | 25 | 100204 | 347 | 64398156 |
Neutropenic infection | 68.55 | 13.20 | 41 | 100188 | 1924 | 64396579 |
Injection site erythema | 67.20 | 13.20 | 14 | 100215 | 70786 | 64327717 |
Febrile bone marrow aplasia | 66.90 | 13.20 | 85 | 100144 | 11170 | 64387333 |
Nail dystrophy | 66.29 | 13.20 | 30 | 100199 | 783 | 64397720 |
Pseudocirrhosis | 66.24 | 13.20 | 28 | 100201 | 617 | 64397886 |
Feeling abnormal | 66.08 | 13.20 | 66 | 100163 | 133536 | 64264967 |
Multifocal micronodular pneumocyte hyperplasia | 65.51 | 13.20 | 17 | 100212 | 69 | 64398434 |
Bronchial polyp | 65.13 | 13.20 | 17 | 100212 | 71 | 64398432 |
Nail discolouration | 64.27 | 13.20 | 43 | 100186 | 2457 | 64396046 |
Blood pressure systolic increased | 64.15 | 13.20 | 3 | 100226 | 49450 | 64349053 |
Hospitalisation | 63.40 | 13.20 | 19 | 100210 | 75188 | 64323315 |
Maternal exposure during pregnancy | 63.37 | 13.20 | 35 | 100194 | 95849 | 64302654 |
Organising pneumonia | 62.92 | 13.20 | 74 | 100155 | 8981 | 64389522 |
Tremor | 62.73 | 13.20 | 83 | 100146 | 148147 | 64250356 |
Prostate cancer metastatic | 62.21 | 13.20 | 47 | 100182 | 3257 | 64395246 |
Intestinal ischaemia | 62.08 | 13.20 | 83 | 100146 | 11466 | 64387037 |
Therapy partial responder | 61.87 | 13.20 | 78 | 100151 | 10170 | 64388333 |
Toxicity to various agents | 59.96 | 13.20 | 326 | 99903 | 363187 | 64035316 |
Injury | 59.95 | 13.20 | 8 | 100221 | 55984 | 64342519 |
Intentional product misuse | 59.62 | 13.20 | 19 | 100210 | 72276 | 64326227 |
Hepatic enzyme increased | 58.92 | 13.20 | 69 | 100160 | 129874 | 64268629 |
Hallucination | 58.50 | 13.20 | 20 | 100209 | 72768 | 64325735 |
International normalised ratio increased | 58.23 | 13.20 | 25 | 100204 | 79142 | 64319361 |
Metastases to spine | 58.15 | 13.20 | 47 | 100182 | 3596 | 64394907 |
Wound | 58.12 | 13.20 | 23 | 100206 | 76454 | 64322049 |
Bradycardia | 57.77 | 13.20 | 59 | 100170 | 118160 | 64280343 |
Arthritis | 57.73 | 13.20 | 29 | 100200 | 83785 | 64314718 |
Agitation | 57.32 | 13.20 | 33 | 100196 | 88334 | 64310169 |
Gastrointestinal necrosis | 56.62 | 13.20 | 53 | 100176 | 4939 | 64393564 |
Incorrect dose administered | 55.68 | 13.20 | 13 | 100216 | 60752 | 64337751 |
Dacryostenosis acquired | 54.86 | 13.20 | 22 | 100207 | 422 | 64398081 |
Pulmonary toxicity | 54.63 | 13.20 | 67 | 100162 | 8494 | 64390009 |
Injection site reaction | 54.17 | 13.20 | 5 | 100224 | 46659 | 64351844 |
Hypoglycaemia | 53.59 | 13.20 | 37 | 100192 | 89855 | 64308648 |
Aggression | 53.54 | 13.20 | 5 | 100224 | 46227 | 64352276 |
Plasma cell myeloma | 53.31 | 13.20 | 5 | 100224 | 46070 | 64352433 |
Drug reaction with eosinophilia and systemic symptoms | 52.97 | 13.20 | 10 | 100219 | 54207 | 64344296 |
Electrocardiogram QT prolonged | 52.49 | 13.20 | 29 | 100200 | 79419 | 64319084 |
Sedation | 52.25 | 13.20 | 3 | 100226 | 41459 | 64357044 |
Neurotoxicity | 52.22 | 13.20 | 125 | 100104 | 27279 | 64371224 |
Enterocolitis | 52.19 | 13.20 | 78 | 100151 | 11940 | 64386563 |
Large intestine perforation | 52.18 | 13.20 | 80 | 100149 | 12524 | 64385979 |
Bacterial translocation | 51.93 | 13.20 | 21 | 100208 | 412 | 64398091 |
Mobility decreased | 51.61 | 13.20 | 35 | 100194 | 85805 | 64312698 |
Loss of personal independence in daily activities | 51.53 | 13.20 | 24 | 100205 | 72430 | 64326073 |
Dermatitis acneiform | 50.56 | 13.20 | 64 | 100165 | 8379 | 64390124 |
Nasal congestion | 50.42 | 13.20 | 15 | 100214 | 59643 | 64338860 |
Anxiety | 50.16 | 13.20 | 155 | 100074 | 202494 | 64196009 |
Osteoarthritis | 49.87 | 13.20 | 18 | 100211 | 63318 | 64335185 |
Onychomadesis | 49.87 | 13.20 | 39 | 100190 | 2845 | 64395658 |
Coma | 49.70 | 13.20 | 38 | 100191 | 87577 | 64310926 |
Periarticular thenar erythema with onycholysis | 49.15 | 13.20 | 11 | 100218 | 19 | 64398484 |
Suicidal ideation | 48.96 | 13.20 | 21 | 100208 | 66521 | 64331982 |
Asthma | 48.28 | 13.20 | 46 | 100183 | 95179 | 64303324 |
Rhabdomyolysis | 48.06 | 13.20 | 43 | 100186 | 91683 | 64306820 |
Nephrolithiasis | 47.35 | 13.20 | 6 | 100223 | 43677 | 64354826 |
Intentional product use issue | 47.27 | 13.20 | 47 | 100182 | 95317 | 64303186 |
Medication error | 47.17 | 13.20 | 10 | 100219 | 49956 | 64348547 |
Carotidynia | 46.66 | 13.20 | 15 | 100214 | 146 | 64398357 |
Injection site swelling | 46.51 | 13.20 | 5 | 100224 | 41348 | 64357155 |
Thrombocytopenia | 46.45 | 13.20 | 542 | 99687 | 223259 | 64175244 |
Tonsillar disorder | 45.99 | 13.20 | 25 | 100204 | 976 | 64397527 |
Pain | 45.85 | 13.20 | 596 | 99633 | 552915 | 63845588 |
Oesophagobronchial fistula | 45.74 | 13.20 | 16 | 100213 | 206 | 64398297 |
Insomnia | 45.72 | 13.20 | 156 | 100073 | 197680 | 64200823 |
Metastases to the mediastinum | 44.48 | 13.20 | 20 | 100209 | 514 | 64397989 |
Cystoid macular oedema | 44.38 | 13.20 | 30 | 100199 | 1744 | 64396759 |
Lactic acidosis | 44.21 | 13.20 | 20 | 100209 | 61390 | 64337113 |
Injection site pruritus | 44.05 | 13.20 | 4 | 100225 | 37822 | 64360681 |
Prostate cancer | 44.04 | 13.20 | 96 | 100133 | 19699 | 64378804 |
Alopecia totalis | 43.96 | 13.20 | 17 | 100212 | 295 | 64398208 |
Exposure during pregnancy | 43.67 | 13.20 | 34 | 100195 | 77641 | 64320862 |
Metastases to soft tissue | 43.56 | 13.20 | 18 | 100211 | 374 | 64398129 |
Blood cholesterol increased | 43.39 | 13.20 | 12 | 100217 | 50054 | 64348449 |
General physical health deterioration | 43.28 | 13.20 | 497 | 99732 | 203928 | 64194575 |
Dyspnoea | 43.08 | 13.20 | 1439 | 98790 | 717235 | 63681268 |
Arthralgia | 42.84 | 13.20 | 460 | 99769 | 441800 | 63956703 |
Influenza | 42.71 | 13.20 | 62 | 100167 | 106469 | 64292034 |
Migraine | 42.70 | 13.20 | 22 | 100207 | 62655 | 64335848 |
Bone lesion | 42.55 | 13.20 | 46 | 100183 | 5091 | 64393412 |
Onychalgia | 42.54 | 13.20 | 22 | 100207 | 775 | 64397728 |
PIK3CA-activated mutation | 41.63 | 13.20 | 19 | 100210 | 506 | 64397997 |
Epistaxis | 41.51 | 13.20 | 278 | 99951 | 97853 | 64300650 |
Chemotherapy | 41.36 | 13.20 | 27 | 100202 | 1480 | 64397023 |
Pneumothorax | 41.20 | 13.20 | 106 | 100123 | 24192 | 64374311 |
Hepatic lesion | 41.14 | 13.20 | 48 | 100181 | 5776 | 64392727 |
Odynophagia | 41.05 | 13.20 | 62 | 100167 | 9579 | 64388924 |
Oesophageal fistula | 40.48 | 13.20 | 16 | 100213 | 295 | 64398208 |
Vascular device infection | 40.47 | 13.20 | 49 | 100180 | 6131 | 64392372 |
Angioedema | 40.22 | 13.20 | 23 | 100206 | 61798 | 64336705 |
Dermatomyositis | 40.19 | 13.20 | 34 | 100195 | 2772 | 64395731 |
Device related thrombosis | 40.01 | 13.20 | 30 | 100199 | 2055 | 64396448 |
Breast pain | 39.89 | 13.20 | 52 | 100177 | 7009 | 64391494 |
Eosinophilia | 39.45 | 13.20 | 6 | 100223 | 38070 | 64360433 |
Cardiac arrest | 39.43 | 13.20 | 116 | 100113 | 153948 | 64244555 |
Lumbosacral radiculoplexus neuropathy | 39.43 | 13.20 | 11 | 100218 | 62 | 64398441 |
Computerised tomogram thorax abnormal | 39.28 | 13.20 | 29 | 100200 | 1940 | 64396563 |
Performance status decreased | 39.22 | 13.20 | 45 | 100184 | 5319 | 64393184 |
Back pain | 38.99 | 13.20 | 575 | 99654 | 249596 | 64148907 |
Blood pressure fluctuation | 38.76 | 13.20 | 16 | 100213 | 51855 | 64346648 |
EGFR gene mutation | 38.05 | 13.20 | 16 | 100213 | 348 | 64398155 |
Nasopharyngitis | 37.97 | 13.20 | 166 | 100063 | 195907 | 64202596 |
Dizziness | 37.89 | 13.20 | 457 | 99772 | 429706 | 63968797 |
Accidental overdose | 37.89 | 13.20 | 4 | 100225 | 33553 | 64364950 |
Constipation | 37.68 | 13.20 | 532 | 99697 | 228805 | 64169698 |
Enterocolitis infectious | 37.67 | 13.20 | 31 | 100198 | 2433 | 64396070 |
Ejection fraction | 37.66 | 13.20 | 24 | 100205 | 1262 | 64397241 |
Blood glucose increased | 37.46 | 13.20 | 59 | 100170 | 98014 | 64300489 |
Swollen tongue | 37.40 | 13.20 | 5 | 100224 | 34949 | 64363554 |
Coronary artery disease | 37.19 | 13.20 | 24 | 100205 | 60409 | 64338094 |
Metastases to chest wall | 36.94 | 13.20 | 16 | 100213 | 375 | 64398128 |
Urticaria | 36.93 | 13.20 | 112 | 100117 | 147205 | 64251298 |
Basal cell carcinoma | 36.62 | 13.20 | 3 | 100226 | 30835 | 64367668 |
Congestive cardiomyopathy | 36.44 | 13.20 | 61 | 100168 | 10283 | 64388220 |
COVID-19 | 36 | 13.20 | 29 | 100200 | 65111 | 64333392 |
Systemic scleroderma | 35.97 | 13.20 | 21 | 100208 | 942 | 64397561 |
Helicobacter infection | 35.56 | 13.20 | 8 | 100221 | 38354 | 64360149 |
Product prescribing error | 35.55 | 13.20 | 6 | 100223 | 35263 | 64363240 |
Paraesthesia | 35.49 | 13.20 | 342 | 99887 | 134180 | 64264323 |
Drug intolerance | 35.30 | 13.20 | 161 | 100068 | 187831 | 64210672 |
Hot flush | 35.29 | 13.20 | 154 | 100075 | 46081 | 64352422 |
Gastrointestinal haemorrhage | 35.05 | 13.20 | 98 | 100131 | 132214 | 64266289 |
Mastectomy | 34.89 | 13.20 | 21 | 100208 | 997 | 64397506 |
Wheezing | 34.20 | 13.20 | 45 | 100184 | 80534 | 64317969 |
Unevaluable event | 33.98 | 13.20 | 18 | 100211 | 50471 | 64348032 |
Asthenopia | 33.93 | 13.20 | 27 | 100202 | 2020 | 64396483 |
Road traffic accident | 33.87 | 13.20 | 4 | 100225 | 30741 | 64367762 |
Exposed bone in jaw | 33.86 | 13.20 | 34 | 100195 | 3453 | 64395050 |
Irritability | 33.39 | 13.20 | 8 | 100221 | 36738 | 64361765 |
Gait disturbance | 33.18 | 13.20 | 146 | 100083 | 172009 | 64226494 |
Blood pressure increased | 32.86 | 13.20 | 147 | 100082 | 172405 | 64226098 |
Vulvovaginal dryness | 32.80 | 13.20 | 24 | 100205 | 1584 | 64396919 |
Acoustic stimulation tests abnormal | 32.70 | 13.20 | 8 | 100221 | 24 | 64398479 |
Psychotic disorder | 32.48 | 13.20 | 7 | 100222 | 34571 | 64363932 |
Full blood count abnormal | 32.46 | 13.20 | 4 | 100225 | 29753 | 64368750 |
Adverse drug reaction | 32.42 | 13.20 | 15 | 100214 | 45449 | 64353054 |
Acute respiratory distress syndrome | 32.29 | 13.20 | 133 | 100096 | 38802 | 64359701 |
Hypertension | 32.29 | 13.20 | 253 | 99976 | 259008 | 64139495 |
Obstructive shock | 32.08 | 13.20 | 9 | 100220 | 52 | 64398451 |
Metastatic neoplasm | 32.03 | 13.20 | 37 | 100192 | 4405 | 64394098 |
Acute interstitial pneumonitis | 31.81 | 13.20 | 20 | 100209 | 1027 | 64397476 |
Purtscher retinopathy | 31.69 | 13.20 | 7 | 100222 | 11 | 64398492 |
Drug resistance | 31.58 | 13.20 | 123 | 100106 | 34979 | 64363524 |
Blood lactate dehydrogenase increased | 31.48 | 13.20 | 118 | 100111 | 32960 | 64365543 |
C-reactive protein abnormal | 31.45 | 13.20 | 4 | 100225 | 29043 | 64369460 |
Dyskinesia | 31.34 | 13.20 | 11 | 100218 | 39377 | 64359126 |
Oral candidiasis | 31.17 | 13.20 | 93 | 100136 | 23119 | 64375384 |
White blood cell count abnormal | 30.99 | 13.20 | 38 | 100191 | 4816 | 64393687 |
Stress | 30.96 | 13.20 | 29 | 100200 | 60505 | 64337998 |
Dysarthria | 30.93 | 13.20 | 28 | 100201 | 59378 | 64339125 |
Blood uric acid decreased | 30.80 | 13.20 | 20 | 100209 | 1086 | 64397417 |
Pericarditis | 30.76 | 13.20 | 31 | 100198 | 62485 | 64336018 |
Treatment failure | 30.58 | 13.20 | 87 | 100142 | 116729 | 64281774 |
Irritable bowel syndrome | 30.49 | 13.20 | 10 | 100219 | 37359 | 64361144 |
Nephritis bacterial | 30.35 | 13.20 | 8 | 100221 | 35 | 64398468 |
Coating in mouth | 30.27 | 13.20 | 12 | 100217 | 223 | 64398280 |
Muscle injury | 30.24 | 13.20 | 3 | 100226 | 26434 | 64372069 |
Treatment noncompliance | 30.01 | 13.20 | 15 | 100214 | 43467 | 64355036 |
Drug level increased | 30.00 | 13.20 | 8 | 100221 | 34188 | 64364315 |
Gastric perforation | 29.98 | 13.20 | 32 | 100197 | 3491 | 64395012 |
Nervousness | 29.85 | 13.20 | 5 | 100224 | 29551 | 64368952 |
Prostate cancer recurrent | 29.83 | 13.20 | 17 | 100212 | 728 | 64397775 |
Pruritus | 29.77 | 13.20 | 326 | 99903 | 312074 | 64086429 |
Device related infection | 29.77 | 13.20 | 110 | 100119 | 30516 | 64367987 |
Cardiac dysfunction | 29.64 | 13.20 | 30 | 100199 | 3076 | 64395427 |
Swelling | 29.60 | 13.20 | 138 | 100091 | 160080 | 64238423 |
Adenocarcinoma | 29.51 | 13.20 | 31 | 100198 | 3320 | 64395183 |
Psoriasis | 29.46 | 13.20 | 41 | 100188 | 71662 | 64326841 |
Hyperfibrinogenaemia | 29.34 | 13.20 | 9 | 100220 | 74 | 64398429 |
Periorbital disorder | 29.31 | 13.20 | 8 | 100221 | 41 | 64398462 |
Vascular fragility | 29.22 | 13.20 | 10 | 100219 | 120 | 64398383 |
Mucosal infection | 28.80 | 13.20 | 14 | 100215 | 431 | 64398072 |
Cardiac failure congestive | 28.79 | 13.20 | 105 | 100124 | 130475 | 64268028 |
Pneumatosis intestinalis | 28.75 | 13.20 | 38 | 100191 | 5191 | 64393312 |
Tumour embolism | 28.71 | 13.20 | 10 | 100219 | 127 | 64398376 |
Barotrauma | 28.65 | 13.20 | 11 | 100218 | 187 | 64398316 |
Erysipelas | 28.65 | 13.20 | 51 | 100178 | 9030 | 64389473 |
Meibomian gland dysfunction | 28.64 | 13.20 | 10 | 100219 | 128 | 64398375 |
Glossodynia | 28.63 | 13.20 | 35 | 100194 | 64661 | 64333842 |
Bronchitis | 28.46 | 13.20 | 81 | 100148 | 108662 | 64289841 |
Myelodysplastic syndrome | 28.46 | 13.20 | 101 | 100128 | 27478 | 64371025 |
Ascites | 28.26 | 13.20 | 179 | 100050 | 61822 | 64336681 |
Nicotinic acid deficiency | 28.22 | 13.20 | 10 | 100219 | 134 | 64398369 |
Acute kidney injury | 28.16 | 13.20 | 510 | 99719 | 448730 | 63949773 |
Therapy cessation | 27.76 | 13.20 | 8 | 100221 | 32481 | 64366022 |
Pulmonary mass | 27.45 | 13.20 | 91 | 100138 | 23925 | 64374578 |
Tongue coated | 27.41 | 13.20 | 19 | 100210 | 1151 | 64397352 |
Karnofsky scale worsened | 27.34 | 13.20 | 5 | 100224 | 0 | 64398503 |
Eubacterium infection | 27.34 | 13.20 | 5 | 100224 | 0 | 64398503 |
Diabetes mellitus | 27.32 | 13.20 | 38 | 100191 | 66436 | 64332067 |
Injection site haemorrhage | 27.14 | 13.20 | 3 | 100226 | 24275 | 64374228 |
Osteonecrosis | 27.11 | 13.20 | 101 | 100128 | 28128 | 64370375 |
Scleroderma renal crisis | 27.09 | 13.20 | 13 | 100216 | 389 | 64398114 |
Drug dependence | 27.03 | 13.20 | 9 | 100220 | 33303 | 64365200 |
Discomfort | 26.95 | 13.20 | 53 | 100176 | 80825 | 64317678 |
Myalgia | 26.86 | 13.20 | 370 | 99859 | 158247 | 64240256 |
Tumour pain | 26.83 | 13.20 | 23 | 100206 | 1910 | 64396593 |
Blood creatinine decreased | 26.76 | 13.20 | 43 | 100186 | 7007 | 64391496 |
Blood creatine phosphokinase increased | 26.63 | 13.20 | 31 | 100198 | 58527 | 64339976 |
Mastitis | 26.61 | 13.20 | 23 | 100206 | 1931 | 64396572 |
Gas gangrene | 26.56 | 13.20 | 11 | 100218 | 230 | 64398273 |
Vessel puncture site bruise | 26.43 | 13.20 | 13 | 100216 | 411 | 64398092 |
Pericardial effusion | 26.42 | 13.20 | 126 | 100103 | 39128 | 64359375 |
Mucosal disorder | 26.39 | 13.20 | 28 | 100201 | 3034 | 64395469 |
Balance disorder | 26.27 | 13.20 | 57 | 100172 | 83869 | 64314634 |
Eosinophil percentage increased | 26.24 | 13.20 | 20 | 100209 | 1404 | 64397099 |
Hydrothorax | 26.18 | 13.20 | 19 | 100210 | 1238 | 64397265 |
Renal failure | 26.16 | 13.20 | 170 | 100059 | 181518 | 64216985 |
Feeling hot | 26.12 | 13.20 | 140 | 100089 | 45523 | 64352980 |
Cystitis noninfective | 26.00 | 13.20 | 18 | 100211 | 1088 | 64397415 |
Cataract | 25.70 | 13.20 | 25 | 100204 | 51237 | 64347266 |
Metastases to ovary | 25.67 | 13.20 | 11 | 100218 | 251 | 64398252 |
Disseminated intravascular coagulation | 25.65 | 13.20 | 109 | 100120 | 32239 | 64366264 |
Emotional distress | 25.53 | 13.20 | 12 | 100217 | 36026 | 64362477 |
Osteoporosis | 25.50 | 13.20 | 17 | 100212 | 42063 | 64356440 |
Cardiomyopathy | 25.43 | 13.20 | 92 | 100137 | 25264 | 64373239 |
Perforation | 25.39 | 13.20 | 18 | 100211 | 1130 | 64397373 |
Malignant pleural effusion | 25.34 | 13.20 | 27 | 100202 | 2940 | 64395563 |
Delirium | 25.14 | 13.20 | 43 | 100186 | 69151 | 64329352 |
Intestinal perforation | 25.13 | 13.20 | 66 | 100163 | 15247 | 64383256 |
Menopausal disorder | 25.01 | 13.20 | 7 | 100222 | 40 | 64398463 |
Axillary pain | 24.84 | 13.20 | 21 | 100208 | 1711 | 64396792 |
Osteolysis | 24.81 | 13.20 | 26 | 100203 | 2777 | 64395726 |
Cytomegalovirus oesophagitis | 24.64 | 13.20 | 14 | 100215 | 596 | 64397907 |
Necrotising retinitis | 24.29 | 13.20 | 17 | 100212 | 1046 | 64397457 |
Nail ridging | 24.17 | 13.20 | 11 | 100218 | 291 | 64398212 |
Respiratory arrest | 24.15 | 13.20 | 28 | 100201 | 52957 | 64345546 |
Sopor | 24.09 | 13.20 | 8 | 100221 | 29653 | 64368850 |
Excessive eye blinking | 23.89 | 13.20 | 18 | 100211 | 1242 | 64397261 |
Disorientation | 23.87 | 13.20 | 31 | 100198 | 55797 | 64342706 |
Invasive ductal breast carcinoma | 23.74 | 13.20 | 34 | 100195 | 5008 | 64393495 |
Limb injury | 23.68 | 13.20 | 4 | 100225 | 23501 | 64375002 |
Pancreatitis | 23.58 | 13.20 | 35 | 100194 | 59572 | 64338931 |
Neck pain | 23.51 | 13.20 | 37 | 100192 | 61496 | 64337007 |
Gastric disorder | 23.50 | 13.20 | 8 | 100221 | 29189 | 64369314 |
Vein discolouration | 23.49 | 13.20 | 11 | 100218 | 311 | 64398192 |
Nail bed bleeding | 23.49 | 13.20 | 11 | 100218 | 311 | 64398192 |
Mediastinitis | 23.45 | 13.20 | 15 | 100214 | 794 | 64397709 |
Neoplasm recurrence | 23.44 | 13.20 | 29 | 100200 | 3710 | 64394793 |
Asthenia | 23.27 | 13.20 | 848 | 99381 | 427196 | 63971307 |
Product administration error | 23.26 | 13.20 | 7 | 100222 | 27636 | 64370867 |
Radiation necrosis | 23.17 | 13.20 | 11 | 100218 | 321 | 64398182 |
Carbohydrate antigen 15-3 increased | 23.05 | 13.20 | 16 | 100213 | 971 | 64397532 |
Retinal toxicity | 23.03 | 13.20 | 18 | 100211 | 1312 | 64397191 |
Palmar erythema | 23.03 | 13.20 | 20 | 100209 | 1690 | 64396813 |
Muscle spasms | 22.90 | 13.20 | 127 | 100102 | 140896 | 64257607 |
Retinal detachment | 22.89 | 13.20 | 43 | 100186 | 7933 | 64390570 |
Sepsis | 22.86 | 13.20 | 493 | 99736 | 229848 | 64168655 |
Pulmonary hypertension | 22.86 | 13.20 | 20 | 100209 | 43119 | 64355384 |
Hiccups | 22.61 | 13.20 | 44 | 100185 | 8332 | 64390171 |
Abnormal behaviour | 22.60 | 13.20 | 12 | 100217 | 33610 | 64364893 |
Hepatic encephalopathy | 22.57 | 13.20 | 3 | 100226 | 21063 | 64377440 |
Hip fracture | 22.56 | 13.20 | 7 | 100222 | 27092 | 64371411 |
Metastases to thorax | 22.47 | 13.20 | 9 | 100220 | 172 | 64398331 |
Nasal disorder | 22.46 | 13.20 | 25 | 100204 | 2859 | 64395644 |
Liver function test abnormal | 22.43 | 13.20 | 36 | 100193 | 59365 | 64339138 |
Pleural disorder | 22.28 | 13.20 | 14 | 100215 | 718 | 64397785 |
Sclerema | 22.28 | 13.20 | 6 | 100223 | 29 | 64398474 |
Colitis ischaemic | 22.21 | 13.20 | 58 | 100171 | 13356 | 64385147 |
Epidermolysis | 22.08 | 13.20 | 12 | 100217 | 468 | 64398035 |
Gait inability | 22.02 | 13.20 | 20 | 100209 | 42348 | 64356155 |
Osteitis condensans | 21.94 | 13.20 | 6 | 100223 | 31 | 64398472 |
Metastases to gastrointestinal tract | 21.88 | 13.20 | 8 | 100221 | 118 | 64398385 |
Eastern Cooperative Oncology Group performance status worsened | 21.85 | 13.20 | 17 | 100212 | 1231 | 64397272 |
Pharyngeal abscess | 21.68 | 13.20 | 13 | 100216 | 613 | 64397890 |
Type 2 diabetes mellitus | 21.64 | 13.20 | 13 | 100216 | 34007 | 64364496 |
Bone marrow infiltration | 21.58 | 13.20 | 12 | 100217 | 490 | 64398013 |
Clostridium bacteraemia | 21.45 | 13.20 | 10 | 100219 | 280 | 64398223 |
Poisoning | 21.44 | 13.20 | 4 | 100225 | 21875 | 64376628 |
Dysphagia | 21.38 | 13.20 | 257 | 99972 | 106555 | 64291948 |
Gastrointestinal ischaemia | 21.26 | 13.20 | 11 | 100218 | 388 | 64398115 |
Hypervolaemia | 21.21 | 13.20 | 17 | 100212 | 38268 | 64360235 |
Ventricular hypokinesia | 21.20 | 13.20 | 41 | 100188 | 7728 | 64390775 |
Hyperkalaemia | 21.19 | 13.20 | 83 | 100146 | 101046 | 64297457 |
Mucocutaneous disorder | 21.17 | 13.20 | 8 | 100221 | 130 | 64398373 |
Radiation pneumonitis | 21.16 | 13.20 | 26 | 100203 | 3302 | 64395201 |
Post-traumatic pain | 21.13 | 13.20 | 11 | 100218 | 393 | 64398110 |
Vulvitis | 20.94 | 13.20 | 9 | 100220 | 207 | 64398296 |
Acute motor-sensory axonal neuropathy | 20.92 | 13.20 | 11 | 100218 | 401 | 64398102 |
Bursitis | 20.90 | 13.20 | 4 | 100225 | 21481 | 64377022 |
Skin laceration | 20.88 | 13.20 | 6 | 100223 | 24411 | 64374092 |
Joint injury | 20.84 | 13.20 | 5 | 100224 | 22942 | 64375561 |
Cellulitis | 20.83 | 13.20 | 230 | 99999 | 93427 | 64305076 |
Gout | 20.81 | 13.20 | 4 | 100225 | 21409 | 64377094 |
Vascular pain | 20.74 | 13.20 | 14 | 100215 | 812 | 64397691 |
Hormone receptor positive breast cancer | 20.57 | 13.20 | 10 | 100219 | 308 | 64398195 |
Chest discomfort | 20.53 | 13.20 | 273 | 99956 | 115833 | 64282670 |
Oesophagitis | 20.45 | 13.20 | 77 | 100152 | 21553 | 64376950 |
Macroenzyme creatine kinase | 20.43 | 13.20 | 5 | 100224 | 15 | 64398488 |
Metastases to heart | 20.39 | 13.20 | 9 | 100220 | 221 | 64398282 |
Depressed level of consciousness | 20.33 | 13.20 | 62 | 100167 | 81374 | 64317129 |
Therapy responder | 20.22 | 13.20 | 11 | 100218 | 430 | 64398073 |
Unintentional medical device removal | 20.20 | 13.20 | 37 | 100192 | 6697 | 64391806 |
Tumour haemorrhage | 20.16 | 13.20 | 26 | 100203 | 3467 | 64395036 |
Viral infection | 20.08 | 13.20 | 16 | 100213 | 36124 | 64362379 |
Haematochezia | 20.02 | 13.20 | 46 | 100183 | 66327 | 64332176 |
Cytomegalovirus infection | 20.01 | 13.20 | 17 | 100212 | 37182 | 64361321 |
Pancreatitis viral | 19.96 | 13.20 | 5 | 100224 | 17 | 64398486 |
Metabolic acidosis | 19.96 | 13.20 | 51 | 100178 | 70907 | 64327596 |
Troponin I increased | 19.83 | 13.20 | 27 | 100202 | 3794 | 64394709 |
Impaired healing | 19.82 | 13.20 | 40 | 100189 | 60433 | 64338070 |
Enteritis | 19.77 | 13.20 | 52 | 100177 | 12025 | 64386478 |
Hypophagia | 19.75 | 13.20 | 117 | 100112 | 39470 | 64359033 |
Hypovolaemic shock | 19.74 | 13.20 | 47 | 100182 | 10219 | 64388284 |
Obstruction gastric | 19.65 | 13.20 | 17 | 100212 | 1429 | 64397074 |
Superior mesenteric artery syndrome | 19.60 | 13.20 | 8 | 100221 | 161 | 64398342 |
Metastases to nervous system | 19.59 | 13.20 | 6 | 100223 | 49 | 64398454 |
Peritonitis | 19.59 | 13.20 | 84 | 100145 | 24939 | 64373564 |
Multiple sclerosis | 19.59 | 13.20 | 3 | 100226 | 18938 | 64379565 |
Transdifferentiation of neoplasm | 19.54 | 13.20 | 7 | 100222 | 97 | 64398406 |
No adverse event | 19.49 | 13.20 | 10 | 100219 | 28551 | 64369952 |
Blood triglycerides increased | 19.48 | 13.20 | 3 | 100226 | 18863 | 64379640 |
Vaginal prolapse | 19.47 | 13.20 | 9 | 100220 | 247 | 64398256 |
Amnesia | 19.43 | 13.20 | 28 | 100201 | 48241 | 64350262 |
Granulocyte count decreased | 19.39 | 13.20 | 16 | 100213 | 1260 | 64397243 |
Choroidal effusion | 19.37 | 13.20 | 12 | 100217 | 600 | 64397903 |
Monocyte count decreased | 19.27 | 13.20 | 23 | 100206 | 2834 | 64395669 |
Herpes zoster | 19.27 | 13.20 | 61 | 100168 | 79126 | 64319377 |
Osteoradionecrosis | 19.22 | 13.20 | 7 | 100222 | 102 | 64398401 |
Panophthalmitis | 19.22 | 13.20 | 7 | 100222 | 102 | 64398401 |
Recurrent cancer | 19.22 | 13.20 | 21 | 100208 | 2352 | 64396151 |
Trigeminal nerve paresis | 19.11 | 13.20 | 4 | 100225 | 4 | 64398499 |
Infusion site plaque | 19.11 | 13.20 | 4 | 100225 | 4 | 64398499 |
Mucosal toxicity | 19.10 | 13.20 | 11 | 100218 | 481 | 64398022 |
Toxic optic neuropathy | 19.01 | 13.20 | 14 | 100215 | 933 | 64397570 |
Tympanic membrane disorder | 18.98 | 13.20 | 8 | 100221 | 175 | 64398328 |
Lymphadenopathy | 18.98 | 13.20 | 131 | 100098 | 46555 | 64351948 |
Metastases to uterus | 18.89 | 13.20 | 6 | 100223 | 56 | 64398447 |
Breast inflammation | 18.85 | 13.20 | 7 | 100222 | 108 | 64398395 |
Non-small cell lung cancer | 18.80 | 13.20 | 30 | 100199 | 4860 | 64393643 |
Haemolytic uraemic syndrome | 18.77 | 13.20 | 27 | 100202 | 3994 | 64394509 |
Ovarian necrosis | 18.77 | 13.20 | 5 | 100224 | 23 | 64398480 |
Bone disorder | 18.70 | 13.20 | 63 | 100166 | 16696 | 64381807 |
Laboratory test abnormal | 18.67 | 13.20 | 7 | 100222 | 24056 | 64374447 |
Appendiceal abscess | 18.64 | 13.20 | 9 | 100220 | 273 | 64398230 |
Duodenal ulcer perforation | 18.41 | 13.20 | 16 | 100213 | 34609 | 64363894 |
Chronic kidney disease | 18.40 | 13.20 | 39 | 100190 | 57880 | 64340623 |
Oral pain | 18.32 | 13.20 | 88 | 100141 | 27405 | 64371098 |
Neuromuscular toxicity | 18.30 | 13.20 | 8 | 100221 | 192 | 64398311 |
Metastases to adrenals | 18.26 | 13.20 | 15 | 100214 | 1174 | 64397329 |
Necrotising fasciitis | 18.22 | 13.20 | 31 | 100198 | 5295 | 64393208 |
Acute myocardial infarction | 18.19 | 13.20 | 52 | 100177 | 69666 | 64328837 |
Retinitis pigmentosa | 18.18 | 13.20 | 7 | 100222 | 120 | 64398383 |
Peripheral swelling | 18.06 | 13.20 | 223 | 100006 | 208930 | 64189573 |
Skin reaction | 18.04 | 13.20 | 51 | 100178 | 12301 | 64386202 |
Cytokine release syndrome | 18.03 | 13.20 | 5 | 100224 | 20824 | 64377679 |
Mental status changes | 17.95 | 13.20 | 43 | 100186 | 61119 | 64337384 |
Nail infection | 17.92 | 13.20 | 18 | 100211 | 1829 | 64396674 |
Subclavian vein thrombosis | 17.92 | 13.20 | 20 | 100209 | 2294 | 64396209 |
Biliary sepsis | 17.83 | 13.20 | 16 | 100213 | 1412 | 64397091 |
Chromosomal mutation | 17.80 | 13.20 | 5 | 100224 | 29 | 64398474 |
Hypothalamo-pituitary disorder | 17.80 | 13.20 | 14 | 100215 | 1030 | 64397473 |
Cranial nerve disorder | 17.78 | 13.20 | 13 | 100216 | 857 | 64397646 |
Surgery | 17.64 | 13.20 | 11 | 100218 | 28202 | 64370301 |
Administration site extravasation | 17.62 | 13.20 | 14 | 100215 | 1045 | 64397458 |
Iron deficiency anaemia | 17.61 | 13.20 | 6 | 100223 | 21883 | 64376620 |
Vasculitis | 17.59 | 13.20 | 65 | 100164 | 18030 | 64380473 |
Merycism | 17.56 | 13.20 | 8 | 100221 | 212 | 64398291 |
Aorto-oesophageal fistula | 17.53 | 13.20 | 6 | 100223 | 72 | 64398431 |
Vulvovaginal candidiasis | 17.51 | 13.20 | 19 | 100210 | 2111 | 64396392 |
Hydronephrosis | 17.48 | 13.20 | 55 | 100174 | 14070 | 64384433 |
Metastases to muscle | 17.40 | 13.20 | 9 | 100220 | 317 | 64398186 |
Prescribed overdose | 17.38 | 13.20 | 5 | 100224 | 20326 | 64378177 |
Cholangitis sclerosing | 17.34 | 13.20 | 18 | 100211 | 1901 | 64396602 |
Tumour marker increased | 17.34 | 13.20 | 24 | 100205 | 3426 | 64395077 |
Blood alkaline phosphatase increased | 17.33 | 13.20 | 148 | 100081 | 56131 | 64342372 |
Status epilepticus | 17.32 | 13.20 | 6 | 100223 | 21657 | 64376846 |
Intervertebral disc protrusion | 17.20 | 13.20 | 5 | 100224 | 20186 | 64378317 |
Nail bed tenderness | 17.20 | 13.20 | 9 | 100220 | 325 | 64398178 |
Transaminases | 17.17 | 13.20 | 6 | 100223 | 77 | 64398426 |
Osteosclerosis | 17.14 | 13.20 | 24 | 100205 | 3462 | 64395041 |
Restlessness | 17.10 | 13.20 | 22 | 100207 | 39763 | 64358740 |
Leukaemia cutis | 17.09 | 13.20 | 7 | 100222 | 142 | 64398361 |
Therapy interrupted | 16.99 | 13.20 | 5 | 100224 | 20031 | 64378472 |
Pain in extremity | 16.85 | 13.20 | 351 | 99878 | 302734 | 64095769 |
Acquired gene mutation | 16.83 | 13.20 | 18 | 100211 | 1968 | 64396535 |
Abdominal pain | 16.74 | 13.20 | 618 | 99611 | 311757 | 64086746 |
Hyperpyrexia | 16.64 | 13.20 | 29 | 100200 | 5048 | 64393455 |
Malignant neoplasm of pleura | 16.61 | 13.20 | 7 | 100222 | 153 | 64398350 |
Staphylococcal impetigo | 16.60 | 13.20 | 4 | 100225 | 11 | 64398492 |
Hypersomnia | 16.58 | 13.20 | 5 | 100224 | 19712 | 64378791 |
Hyperchlorhydria | 16.48 | 13.20 | 17 | 100212 | 1782 | 64396721 |
Head injury | 16.48 | 13.20 | 16 | 100213 | 32826 | 64365677 |
Traumatic lung injury | 16.48 | 13.20 | 19 | 100210 | 2257 | 64396246 |
Night sweats | 16.48 | 13.20 | 19 | 100210 | 36027 | 64362476 |
Clostridial infection | 16.47 | 13.20 | 29 | 100200 | 5090 | 64393413 |
Cachexia | 16.45 | 13.20 | 41 | 100188 | 9176 | 64389327 |
Miller Fisher syndrome | 16.45 | 13.20 | 7 | 100222 | 157 | 64398346 |
Muscle spasticity | 16.44 | 13.20 | 3 | 100226 | 16666 | 64381837 |
Eye swelling | 16.44 | 13.20 | 7 | 100222 | 22274 | 64376229 |
Spinal pain | 16.41 | 13.20 | 50 | 100179 | 12571 | 64385932 |
Labia enlarged | 16.41 | 13.20 | 3 | 100226 | 0 | 64398503 |
Generalised oedema | 16.33 | 13.20 | 70 | 100159 | 20783 | 64377720 |
Mouth ulceration | 16.25 | 13.20 | 96 | 100133 | 32348 | 64366155 |
Renal impairment | 16.21 | 13.20 | 133 | 100096 | 134884 | 64263619 |
Herpes simplex sepsis | 16.20 | 13.20 | 5 | 100224 | 42 | 64398461 |
Transfusion | 16.19 | 13.20 | 4 | 100225 | 17990 | 64380513 |
Colony stimulating factor therapy | 16.05 | 13.20 | 10 | 100219 | 505 | 64397998 |
Aspergillus infection | 16.04 | 13.20 | 3 | 100226 | 16376 | 64382127 |
Hypoalbuminaemia | 15.95 | 13.20 | 62 | 100167 | 17612 | 64380891 |
Tracheo-oesophageal fistula | 15.95 | 13.20 | 10 | 100219 | 511 | 64397992 |
Therapeutic product effect incomplete | 15.83 | 13.20 | 95 | 100134 | 103387 | 64295116 |
Infusion site vesicles | 15.82 | 13.20 | 9 | 100220 | 384 | 64398119 |
Oesophageal perforation | 15.71 | 13.20 | 13 | 100216 | 1028 | 64397475 |
Memory impairment | 15.70 | 13.20 | 74 | 100155 | 85608 | 64312895 |
Dysaesthesia | 15.69 | 13.20 | 28 | 100201 | 4967 | 64393536 |
Haematoma | 15.67 | 13.20 | 30 | 100199 | 46220 | 64352283 |
Dandy-Walker syndrome | 15.61 | 13.20 | 5 | 100224 | 48 | 64398455 |
Bone cancer metastatic | 15.60 | 13.20 | 7 | 100222 | 179 | 64398324 |
Tubulointerstitial nephritis | 15.58 | 13.20 | 15 | 100214 | 30894 | 64367609 |
Hepatotoxicity | 15.58 | 13.20 | 111 | 100118 | 39851 | 64358652 |
Soft tissue infection | 15.57 | 13.20 | 22 | 100207 | 3201 | 64395302 |
Product quality issue | 15.57 | 13.20 | 14 | 100215 | 29785 | 64368718 |
Thrombotic microangiopathy | 15.50 | 13.20 | 59 | 100170 | 16596 | 64381907 |
Portosplenomesenteric venous thrombosis | 15.46 | 13.20 | 4 | 100225 | 16 | 64398487 |
Ear pain | 15.44 | 13.20 | 10 | 100219 | 25126 | 64373377 |
Ocular hyperaemia | 15.25 | 13.20 | 8 | 100221 | 22556 | 64375947 |
Tracheal stenosis | 15.21 | 13.20 | 8 | 100221 | 292 | 64398211 |
Eye pain | 15.20 | 13.20 | 16 | 100213 | 31609 | 64366894 |
Injection site rash | 15.17 | 13.20 | 3 | 100226 | 15739 | 64382764 |
Heart rate decreased | 15.16 | 13.20 | 40 | 100189 | 55027 | 64343476 |
Scleroderma | 15.12 | 13.20 | 27 | 100202 | 4791 | 64393712 |
Pulmonary embolism | 15.07 | 13.20 | 315 | 99914 | 146041 | 64252462 |
Folate deficiency | 15.07 | 13.20 | 20 | 100209 | 2743 | 64395760 |
Pituitary tumour | 15.02 | 13.20 | 13 | 100216 | 1093 | 64397410 |
Tracheal fistula | 15.01 | 13.20 | 6 | 100223 | 114 | 64398389 |
Hypertransaminasaemia | 15.01 | 13.20 | 34 | 100195 | 7157 | 64391346 |
Haemodialysis | 14.97 | 13.20 | 4 | 100225 | 17073 | 64381430 |
Inflammatory carcinoma of the breast | 14.91 | 13.20 | 4 | 100225 | 19 | 64398484 |
Therapeutic response unexpected | 14.87 | 13.20 | 4 | 100225 | 16997 | 64381506 |
Subdural haematoma | 14.87 | 13.20 | 13 | 100216 | 28041 | 64370462 |
Procedural pain | 14.85 | 13.20 | 3 | 100226 | 15505 | 64382998 |
Left ventricular dilatation | 14.82 | 13.20 | 12 | 100217 | 920 | 64397583 |
Ear infection | 14.80 | 13.20 | 9 | 100220 | 23395 | 64375108 |
Metastatic lymphoma | 14.76 | 13.20 | 7 | 100222 | 204 | 64398299 |
Paralysis recurrent laryngeal nerve | 14.64 | 13.20 | 6 | 100223 | 122 | 64398381 |
Hallucination, visual | 14.63 | 13.20 | 13 | 100216 | 27821 | 64370682 |
Urogenital prolapse | 14.58 | 13.20 | 4 | 100225 | 21 | 64398482 |
Cholestasis | 14.44 | 13.20 | 30 | 100199 | 44842 | 64353661 |
Joint range of motion decreased | 14.39 | 13.20 | 6 | 100223 | 19337 | 64379166 |
Red cell distribution width increased | 14.39 | 13.20 | 47 | 100182 | 12262 | 64386241 |
Colitis ulcerative | 14.37 | 13.20 | 9 | 100220 | 23019 | 64375484 |
Neutrophil count abnormal | 14.33 | 13.20 | 20 | 100209 | 2876 | 64395627 |
Sarcomatosis | 14.33 | 13.20 | 3 | 100226 | 3 | 64398500 |
Hyperchromasia | 14.33 | 13.20 | 3 | 100226 | 3 | 64398500 |
Blood pressure systolic inspiratory decreased | 14.33 | 13.20 | 3 | 100226 | 3 | 64398500 |
Subretinal hyperreflective exudation | 14.33 | 13.20 | 3 | 100226 | 3 | 64398500 |
Non-pitting oedema | 14.33 | 13.20 | 3 | 100226 | 3 | 64398500 |
Extravasation | 14.33 | 13.20 | 21 | 100208 | 3159 | 64395344 |
Abdominal rigidity | 14.30 | 13.20 | 19 | 100210 | 2608 | 64395895 |
Dysuria | 14.24 | 13.20 | 113 | 100116 | 41944 | 64356559 |
Foot deformity | 14.22 | 13.20 | 4 | 100225 | 16500 | 64382003 |
Face oedema | 14.21 | 13.20 | 76 | 100153 | 24685 | 64373818 |
Sinus bradycardia | 14.21 | 13.20 | 9 | 100220 | 22884 | 64375619 |
Metastases to bladder | 14.15 | 13.20 | 7 | 100222 | 224 | 64398279 |
Laryngeal oedema | 14.15 | 13.20 | 33 | 100196 | 7080 | 64391423 |
Abortion spontaneous | 14.13 | 13.20 | 11 | 100218 | 25132 | 64373371 |
Borrelia infection | 14.12 | 13.20 | 6 | 100223 | 134 | 64398369 |
Hypersensitivity pneumonitis | 14.07 | 13.20 | 21 | 100208 | 3211 | 64395292 |
Gastrointestinal perforation | 14.05 | 13.20 | 28 | 100201 | 5396 | 64393107 |
Glaucoma | 14.01 | 13.20 | 4 | 100225 | 16344 | 64382159 |
Upper limb fracture | 13.98 | 13.20 | 3 | 100226 | 14863 | 64383640 |
Acute hepatic failure | 13.96 | 13.20 | 12 | 100217 | 26100 | 64372403 |
Carotid artery aneurysm | 13.93 | 13.20 | 7 | 100222 | 232 | 64398271 |
Adverse event | 13.92 | 13.20 | 25 | 100204 | 39464 | 64359039 |
Muscle necrosis | 13.90 | 13.20 | 13 | 100216 | 1210 | 64397293 |
Fear | 13.85 | 13.20 | 7 | 100222 | 20164 | 64378339 |
Sleep disorder | 13.83 | 13.20 | 47 | 100182 | 59662 | 64338841 |
Metastases to abdominal cavity | 13.81 | 13.20 | 9 | 100220 | 492 | 64398011 |
Diabetes mellitus inadequate control | 13.77 | 13.20 | 8 | 100221 | 21313 | 64377190 |
Renal disorder | 13.76 | 13.20 | 21 | 100208 | 35344 | 64363159 |
Papilloedema | 13.76 | 13.20 | 28 | 100201 | 5477 | 64393026 |
Ventricular tachycardia | 13.67 | 13.20 | 20 | 100209 | 34245 | 64364258 |
Underdose | 13.65 | 13.20 | 12 | 100217 | 25817 | 64372686 |
Chondritis | 13.65 | 13.20 | 6 | 100223 | 146 | 64398357 |
Drug ineffective for unapproved indication | 13.61 | 13.20 | 17 | 100212 | 31116 | 64367387 |
Breast necrosis | 13.60 | 13.20 | 5 | 100224 | 75 | 64398428 |
Cancer pain | 13.55 | 13.20 | 24 | 100205 | 4233 | 64394270 |
Femur fracture | 13.54 | 13.20 | 20 | 100209 | 34115 | 64364388 |
Non-small cell lung cancer metastatic | 13.54 | 13.20 | 11 | 100218 | 848 | 64397655 |
Tooth extraction | 13.40 | 13.20 | 39 | 100190 | 9562 | 64388941 |
Atypical haemolytic uraemic syndrome | 13.38 | 13.20 | 10 | 100219 | 682 | 64397821 |
Generalised tonic-clonic seizure | 13.38 | 13.20 | 26 | 100203 | 39831 | 64358672 |
Diabetic ketoacidosis | 13.36 | 13.20 | 16 | 100213 | 29829 | 64368674 |
Polyneuropathy in malignant disease | 13.35 | 13.20 | 6 | 100223 | 154 | 64398349 |
Parkinsonism | 13.31 | 13.20 | 3 | 100226 | 14370 | 64384133 |
Postural orthostatic tachycardia syndrome | 13.25 | 13.20 | 9 | 100220 | 527 | 64397976 |
Fibrous histiocytoma | 13.21 | 13.20 | 9 | 100220 | 530 | 64397973 |
None
Source | Code | Description |
---|---|---|
ATC | L01CD02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Taxanes |
FDA PE | N0000175085 | Microtubule Inhibition |
FDA EPC | N0000175592 | Microtubule Inhibitor |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:38068 | antimalarials |
CHEBI has role | CHEBI:47868 | photosensitising agent |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D050257 | Tubulin Modulators |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
Carcinoma of breast | indication | 254838004 | DOID:3459 |
Malignant tumor of head and/or neck | indication | 255056009 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Malignant tumor of prostate | indication | 399068003 | DOID:10283 |
Metastatic Breast Carcinoma | indication | ||
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Malignant tumor of esophagus | off-label use | 363402007 | |
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Invasive Bladder Malignancy | off-label use | ||
Refractory Osteosarcoma | off-label use | ||
Asthenia | contraindication | 13791008 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Cardiac tamponade | contraindication | 35304003 | DOID:115 |
Body fluid retention | contraindication | 43498006 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Diarrhea | contraindication | 62315008 | |
Acute infectious disease | contraindication | 63171007 | |
Peripheral motor neuropathy | contraindication | 95663000 | DOID:683 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Peripheral edema | contraindication | 271809000 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Ascites | contraindication | 389026000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Pleural Effusions | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.9 | acidic |
pKa2 | 11.64 | acidic |
pKa3 | 12.4 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | ID50 | 6.70 | WOMBAT-PK | CHEMBL | |||
Multidrug resistance protein 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Epidermal growth factor receptor | Kinase | INHIBITOR | Kd | 9.09 | WOMBAT-PK | ||||
Substance-K receptor | GPCR | Ki | 6.28 | DRUG MATRIX | |||||
Growth hormone-releasing hormone receptor | GPCR | IC50 | 9.85 | CHEMBL | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Nucleotide-binding oligomerization domain-containing protein 2 | Cytosolic other | IC50 | 5.30 | CHEMBL |
ID | Source |
---|---|
4020968 | VUID |
N0000148441 | NUI |
D02165 | KEGG_DRUG |
1299922 | RXNORM |
4020968 | VANDF |
C0246415 | UMLSCUI |
CHEBI:59809 | CHEBI |
TXL | PDB_CHEM_ID |
CHEMBL3545252 | ChEMBL_ID |
CHEMBL92 | ChEMBL_ID |
D000077143 | MESH_DESCRIPTOR_UI |
DB01248 | DRUGBANK_ID |
6809 | IUPHAR_LIGAND_ID |
15H5577CQD | UNII |
148124 | PUBCHEM_CID |
178776 | MMSL |
180476 | MMSL |
4626 | MMSL |
5984 | MMSL |
d04009 | MMSL |
005187 | NDDF |
005188 | NDDF |
108806006 | SNOMEDCT_US |
386918005 | SNOMEDCT_US |
6621 | INN_ID |
148408-66-6 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9204 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9205 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0016 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0201 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0365 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0366 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0367 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0368 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1732 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2026 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2956 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4235 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-5068 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7870 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1020 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1021 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1022 | INJECTION, SOLUTION, CONCENTRATE | 160 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
DOCETAXEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-231 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 30 sections |
DOCETAXEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-267 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-245 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 29 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-001 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 28 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-006 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 28 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-010 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 28 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-258 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 26 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-259 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 26 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-389 | INJECTION, SOLUTION | 160 mg | INTRAVENOUS | ANDA | 26 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-610 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 26 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-611 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 26 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-734 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 22 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-765 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 22 sections |