Stem definition | Drug id | CAS RN |
---|---|---|
antineoplastics, taxane derivatives | 939 | 114977-28-5 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 5 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.15 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 14 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 14, 1996 | FDA | SANOFI AVENTIS US |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 1669.12 | 14.07 | 1347 | 85567 | 104198 | 56100955 |
Neutropenia | 1446.97 | 14.07 | 1484 | 85430 | 156683 | 56048470 |
Palmar-plantar erythrodysaesthesia syndrome | 1008.37 | 14.07 | 539 | 86375 | 20526 | 56184627 |
Myelosuppression | 1006.14 | 14.07 | 506 | 86408 | 16949 | 56188204 |
Diarrhoea | 996.74 | 14.07 | 2674 | 84240 | 635833 | 55569320 |
Malignant neoplasm progression | 931.13 | 14.07 | 827 | 86087 | 72760 | 56132393 |
Disease progression | 858.84 | 14.07 | 930 | 85984 | 104243 | 56100910 |
Mucosal inflammation | 769.18 | 14.07 | 590 | 86324 | 42220 | 56162933 |
Ejection fraction decreased | 742.77 | 14.07 | 432 | 86482 | 19409 | 56185744 |
Neuropathy peripheral | 652.86 | 14.07 | 799 | 86115 | 102094 | 56103059 |
Metastases to bone | 626.85 | 14.07 | 385 | 86529 | 19123 | 56186030 |
Bone marrow failure | 591.10 | 14.07 | 427 | 86487 | 27859 | 56177294 |
Rheumatoid arthritis | 568.74 | 14.07 | 4 | 86910 | 382600 | 55822553 |
Metastases to liver | 549.79 | 14.07 | 368 | 86546 | 21218 | 56183935 |
Drug ineffective | 420.52 | 14.07 | 483 | 86431 | 918506 | 55286647 |
Metastases to central nervous system | 403.86 | 14.07 | 245 | 86669 | 11891 | 56193262 |
Metastases to lung | 401.40 | 14.07 | 241 | 86673 | 11477 | 56193676 |
Breast cancer metastatic | 356.55 | 14.07 | 248 | 86666 | 15221 | 56189932 |
Agranulocytosis | 354.47 | 14.07 | 288 | 86626 | 22371 | 56182782 |
Metastases to lymph nodes | 343.98 | 14.07 | 186 | 86728 | 7237 | 56197916 |
Cardiotoxicity | 311.42 | 14.07 | 176 | 86738 | 7474 | 56197679 |
Neutropenic sepsis | 305.24 | 14.07 | 224 | 86690 | 14961 | 56190192 |
Joint swelling | 304.67 | 14.07 | 43 | 86871 | 289757 | 55915396 |
Neoplasm progression | 276.41 | 14.07 | 292 | 86622 | 31724 | 56173429 |
Polyneuropathy | 267.95 | 14.07 | 195 | 86719 | 12855 | 56192298 |
Leukopenia | 264.08 | 14.07 | 427 | 86487 | 70513 | 56134640 |
Skin toxicity | 261.71 | 14.07 | 128 | 86786 | 4025 | 56201128 |
Contraindicated product administered | 247.89 | 14.07 | 9 | 86905 | 186277 | 56018876 |
Systemic lupus erythematosus | 245.69 | 14.07 | 7 | 86907 | 180071 | 56025082 |
Peripheral sensory neuropathy | 238.05 | 14.07 | 143 | 86771 | 6813 | 56198340 |
Arthropathy | 226.93 | 14.07 | 23 | 86891 | 200252 | 56004901 |
Therapeutic product effect decreased | 226.10 | 14.07 | 8 | 86906 | 169444 | 56035709 |
Fall | 225.07 | 14.07 | 137 | 86777 | 357373 | 55847780 |
Pleural effusion | 224.76 | 14.07 | 442 | 86472 | 85038 | 56120115 |
Breast cancer recurrent | 222.61 | 14.07 | 114 | 86800 | 3961 | 56201192 |
Product dose omission issue | 211.31 | 14.07 | 32 | 86882 | 204721 | 56000432 |
Breast cancer | 211.12 | 14.07 | 315 | 86599 | 48518 | 56156635 |
Neutrophil count decreased | 207.74 | 14.07 | 316 | 86598 | 49506 | 56155647 |
Vomiting | 205.67 | 14.07 | 1393 | 85521 | 496835 | 55708318 |
Haematotoxicity | 201.64 | 14.07 | 138 | 86776 | 8245 | 56196908 |
Acute myeloid leukaemia | 200.97 | 14.07 | 184 | 86730 | 16788 | 56188365 |
Alopecia areata | 200.35 | 14.07 | 78 | 86836 | 1389 | 56203764 |
Left ventricular dysfunction | 190.20 | 14.07 | 149 | 86765 | 10974 | 56194179 |
Bone pain | 189.33 | 14.07 | 304 | 86610 | 49881 | 56155272 |
Nausea | 187.67 | 14.07 | 1899 | 85015 | 762279 | 55442874 |
Sinusitis | 184.20 | 14.07 | 40 | 86874 | 197541 | 56007612 |
Completed suicide | 183.26 | 14.07 | 5 | 86909 | 133828 | 56071325 |
Hand deformity | 180.62 | 14.07 | 6 | 86908 | 134486 | 56070667 |
Colitis | 179.71 | 14.07 | 269 | 86645 | 41542 | 56163611 |
Abdominal discomfort | 177.56 | 14.07 | 104 | 86810 | 277170 | 55927983 |
Decreased appetite | 175.08 | 14.07 | 736 | 86178 | 218495 | 55986658 |
Drug hypersensitivity | 172.32 | 14.07 | 106 | 86808 | 275099 | 55930054 |
Pyrexia | 171.46 | 14.07 | 1169 | 85745 | 417604 | 55787549 |
Neutropenic colitis | 168.23 | 14.07 | 83 | 86831 | 2660 | 56202493 |
White blood cell count decreased | 168.03 | 14.07 | 501 | 86413 | 125489 | 56079664 |
Metastasis | 167.99 | 14.07 | 100 | 86814 | 4684 | 56200469 |
Madarosis | 167.94 | 14.07 | 83 | 86831 | 2670 | 56202483 |
Onycholysis | 166.00 | 14.07 | 67 | 86847 | 1317 | 56203836 |
Hair colour changes | 163.99 | 14.07 | 83 | 86831 | 2812 | 56202341 |
Maternal exposure during pregnancy | 163.76 | 14.07 | 45 | 86869 | 189508 | 56015645 |
Condition aggravated | 163.51 | 14.07 | 175 | 86739 | 344723 | 55860430 |
Nail disorder | 163.33 | 14.07 | 138 | 86776 | 11313 | 56193840 |
Aortitis | 163.31 | 14.07 | 61 | 86853 | 965 | 56204188 |
Stomatitis | 162.62 | 14.07 | 482 | 86432 | 120328 | 56084825 |
Interstitial lung disease | 160.88 | 14.07 | 304 | 86610 | 56759 | 56148394 |
Flushing | 147.52 | 14.07 | 331 | 86583 | 69769 | 56135384 |
Erythema | 144.01 | 14.07 | 548 | 86366 | 155391 | 56049762 |
Metastases to skin | 142.54 | 14.07 | 61 | 86853 | 1397 | 56203756 |
Hair texture abnormal | 140.96 | 14.07 | 83 | 86831 | 3809 | 56201344 |
Second primary malignancy | 139.35 | 14.07 | 105 | 86809 | 7297 | 56197856 |
Wound | 137.98 | 14.07 | 24 | 86890 | 138780 | 56066373 |
Anaemia | 137.48 | 14.07 | 792 | 86122 | 266719 | 55938434 |
Treatment failure | 135.40 | 14.07 | 47 | 86867 | 170345 | 56034808 |
Glossodynia | 133.92 | 14.07 | 35 | 86879 | 152423 | 56052730 |
Gastrointestinal toxicity | 133.25 | 14.07 | 95 | 86819 | 6061 | 56199092 |
Musculoskeletal stiffness | 131.10 | 14.07 | 39 | 86875 | 155968 | 56049185 |
Product use issue | 130.48 | 14.07 | 62 | 86852 | 185979 | 56019174 |
Confusional state | 130.47 | 14.07 | 80 | 86834 | 208075 | 55997078 |
Neutropenic infection | 130.37 | 14.07 | 53 | 86861 | 1062 | 56204091 |
Injection site pain | 128.64 | 14.07 | 15 | 86899 | 117103 | 56088050 |
Recall phenomenon | 128.27 | 14.07 | 44 | 86870 | 536 | 56204617 |
Skin exfoliation | 127.65 | 14.07 | 215 | 86699 | 36685 | 56168468 |
Lymphoedema | 126.29 | 14.07 | 115 | 86799 | 10415 | 56194738 |
Weight increased | 125.92 | 14.07 | 102 | 86812 | 229601 | 55975552 |
Neurotoxicity | 125.64 | 14.07 | 138 | 86776 | 15657 | 56189496 |
Nail toxicity | 124.60 | 14.07 | 38 | 86876 | 308 | 56204845 |
Pain | 123.63 | 14.07 | 566 | 86348 | 662618 | 55542535 |
Somnolence | 116.84 | 14.07 | 53 | 86861 | 163360 | 56041793 |
Dysgeusia | 114.09 | 14.07 | 217 | 86697 | 40698 | 56164455 |
Epistaxis | 108.42 | 14.07 | 286 | 86628 | 66737 | 56138416 |
Swelling | 107.67 | 14.07 | 127 | 86787 | 239644 | 55965509 |
Thrombocytopenia | 107.54 | 14.07 | 456 | 86458 | 135768 | 56069385 |
Biopsy lung abnormal | 104.36 | 14.07 | 28 | 86886 | 134 | 56205019 |
Hepatic enzyme increased | 103.09 | 14.07 | 69 | 86845 | 171315 | 56033838 |
Metastases to pleura | 100.48 | 14.07 | 47 | 86867 | 1335 | 56203818 |
Paronychia | 99.83 | 14.07 | 73 | 86841 | 4845 | 56200308 |
Dehydration | 99.68 | 14.07 | 497 | 86417 | 158328 | 56046825 |
Lacrimation increased | 99.53 | 14.07 | 132 | 86782 | 18216 | 56186937 |
Helicobacter infection | 99.31 | 14.07 | 3 | 86911 | 73265 | 56131888 |
Capillary leak syndrome | 98.78 | 14.07 | 52 | 86862 | 1914 | 56203239 |
Contusion | 97.66 | 14.07 | 38 | 86876 | 128392 | 56076761 |
Overdose | 95.42 | 14.07 | 23 | 86891 | 105807 | 56099346 |
Hypokalaemia | 93.04 | 14.07 | 339 | 86575 | 94098 | 56111055 |
Drug abuse | 90.80 | 14.07 | 3 | 86911 | 67607 | 56137546 |
Pericarditis | 90.09 | 14.07 | 28 | 86886 | 108895 | 56096258 |
Exposure during pregnancy | 88.78 | 14.07 | 50 | 86864 | 136292 | 56068861 |
Pneumonitis | 88.73 | 14.07 | 168 | 86746 | 31396 | 56173757 |
Lymphangiosis carcinomatosa | 86.27 | 14.07 | 41 | 86873 | 1208 | 56203945 |
Organising pneumonia | 85.92 | 14.07 | 69 | 86845 | 5266 | 56199887 |
Dermatitis | 85.24 | 14.07 | 111 | 86803 | 15046 | 56190107 |
Headache | 84.47 | 14.07 | 512 | 86402 | 558532 | 55646621 |
Drug intolerance | 82.32 | 14.07 | 179 | 86735 | 264639 | 55940514 |
Myalgia | 81.30 | 14.07 | 411 | 86503 | 131614 | 56073539 |
Nail dystrophy | 80.62 | 14.07 | 36 | 86878 | 916 | 56204237 |
Radiation skin injury | 80.11 | 14.07 | 35 | 86879 | 844 | 56204309 |
Injection site erythema | 80.06 | 14.07 | 12 | 86902 | 77436 | 56127717 |
Invasive ductal breast carcinoma | 78.84 | 14.07 | 73 | 86841 | 6753 | 56198400 |
Arthritis | 78.50 | 14.07 | 28 | 86886 | 99824 | 56105329 |
Osteoarthritis | 77.36 | 14.07 | 15 | 86899 | 80281 | 56124872 |
Duodenal ulcer perforation | 76.94 | 14.07 | 8 | 86906 | 68334 | 56136819 |
Vascular device infection | 76.91 | 14.07 | 66 | 86848 | 5524 | 56199629 |
Myositis | 76.20 | 14.07 | 79 | 86835 | 8389 | 56196764 |
Injury | 75.89 | 14.07 | 4 | 86910 | 59847 | 56145306 |
Blood cholesterol increased | 75.59 | 14.07 | 11 | 86903 | 72568 | 56132585 |
Acute promyelocytic leukaemia | 74.90 | 14.07 | 34 | 86880 | 900 | 56204253 |
Psoriasis | 74.58 | 14.07 | 25 | 86889 | 92667 | 56112486 |
Hospitalisation | 74.43 | 14.07 | 13 | 86901 | 74987 | 56130166 |
Disease recurrence | 73.35 | 14.07 | 132 | 86782 | 23728 | 56181425 |
Discomfort | 72.69 | 14.07 | 67 | 86847 | 141694 | 56063459 |
Nail discolouration | 71.93 | 14.07 | 46 | 86868 | 2450 | 56202703 |
Febrile bone marrow aplasia | 71.52 | 14.07 | 68 | 86846 | 6504 | 56198649 |
Large intestine perforation | 70.21 | 14.07 | 73 | 86841 | 7778 | 56197375 |
Multifocal micronodular pneumocyte hyperplasia | 69.50 | 14.07 | 18 | 86896 | 73 | 56205080 |
Bronchial polyp | 69.50 | 14.07 | 18 | 86896 | 73 | 56205080 |
Metastases to spine | 69.04 | 14.07 | 48 | 86866 | 2941 | 56202212 |
Irritable bowel syndrome | 67.64 | 14.07 | 12 | 86902 | 68446 | 56136707 |
Loss of personal independence in daily activities | 67.13 | 14.07 | 21 | 86893 | 81348 | 56123805 |
Metastases to peritoneum | 66.49 | 14.07 | 47 | 86867 | 2957 | 56202196 |
Mobility decreased | 66.33 | 14.07 | 35 | 86879 | 98956 | 56106197 |
Inappropriate schedule of product administration | 64.50 | 14.07 | 24 | 86890 | 83363 | 56121790 |
Dermatitis acneiform | 63.28 | 14.07 | 53 | 86861 | 4291 | 56200862 |
Feeling abnormal | 62.93 | 14.07 | 68 | 86846 | 133534 | 56071619 |
Erysipelas | 62.60 | 14.07 | 66 | 86848 | 7147 | 56198006 |
Suicide attempt | 62.04 | 14.07 | 8 | 86906 | 57828 | 56147325 |
Myocardial infarction | 61.98 | 14.07 | 33 | 86881 | 92837 | 56112316 |
Cardiomyopathy | 61.98 | 14.07 | 99 | 86815 | 16159 | 56188994 |
Ascites | 61.49 | 14.07 | 161 | 86753 | 37383 | 56167770 |
Cerebrovascular accident | 60.97 | 14.07 | 39 | 86875 | 99231 | 56105922 |
HER2 positive breast cancer | 60.65 | 14.07 | 23 | 86891 | 380 | 56204773 |
Hepatic function abnormal | 60.54 | 14.07 | 152 | 86762 | 34406 | 56170747 |
Device related thrombosis | 60.00 | 14.07 | 35 | 86879 | 1578 | 56203575 |
Pseudocirrhosis | 59.97 | 14.07 | 26 | 86888 | 615 | 56204538 |
Constipation | 59.57 | 14.07 | 523 | 86391 | 201420 | 56003733 |
Plasma cell myeloma | 59.51 | 14.07 | 3 | 86911 | 46643 | 56158510 |
Adverse drug reaction | 59.00 | 14.07 | 14 | 86900 | 65118 | 56140035 |
Depression | 58.23 | 14.07 | 119 | 86795 | 179998 | 56025155 |
Migraine | 57.69 | 14.07 | 31 | 86883 | 86766 | 56118387 |
Injection site reaction | 55.61 | 14.07 | 8 | 86906 | 53239 | 56151914 |
Blood lactate dehydrogenase increased | 55.59 | 14.07 | 108 | 86806 | 20567 | 56184586 |
Congestive cardiomyopathy | 55.47 | 14.07 | 56 | 86858 | 5763 | 56199390 |
Asthenia | 55.15 | 14.07 | 788 | 86126 | 342185 | 55862968 |
Injection site swelling | 54.98 | 14.07 | 3 | 86911 | 43575 | 56161578 |
Dyspnoea | 54.08 | 14.07 | 1245 | 85669 | 591332 | 55613821 |
Asthma | 53.54 | 14.07 | 57 | 86857 | 112713 | 56092440 |
Enterocolitis infectious | 52.57 | 14.07 | 32 | 86882 | 1561 | 56203592 |
Intentional product use issue | 52.48 | 14.07 | 46 | 86868 | 99687 | 56105466 |
Incorrect dose administered | 52.37 | 14.07 | 9 | 86905 | 52538 | 56152615 |
Impaired healing | 52.13 | 14.07 | 35 | 86879 | 86806 | 56118347 |
Therapy partial responder | 51.75 | 14.07 | 62 | 86852 | 7723 | 56197430 |
Performance status decreased | 51.44 | 14.07 | 42 | 86872 | 3281 | 56201872 |
Periarticular thenar erythema with onycholysis | 51.22 | 14.07 | 11 | 86903 | 14 | 56205139 |
Gastrointestinal necrosis | 51.10 | 14.07 | 38 | 86876 | 2588 | 56202565 |
Ventricular hypokinesia | 50.61 | 14.07 | 46 | 86868 | 4155 | 56200998 |
Device related infection | 50.17 | 14.07 | 107 | 86807 | 21773 | 56183380 |
Dermatomyositis | 49.88 | 14.07 | 38 | 86876 | 2684 | 56202469 |
Hot flush | 49.64 | 14.07 | 172 | 86742 | 46554 | 56158599 |
Injection site pruritus | 49.63 | 14.07 | 4 | 86910 | 41927 | 56163226 |
Metastases to meninges | 49.05 | 14.07 | 35 | 86879 | 2235 | 56202918 |
Arthralgia | 48.95 | 14.07 | 517 | 86397 | 501152 | 55704001 |
Lumbosacral radiculoplexus neuropathy | 48.86 | 14.07 | 11 | 86903 | 20 | 56205133 |
Blood pressure systolic increased | 48.04 | 14.07 | 4 | 86910 | 40832 | 56164321 |
Enterocolitis | 47.92 | 14.07 | 57 | 86857 | 7047 | 56198106 |
Cellulitis | 46.57 | 14.07 | 234 | 86680 | 74715 | 56130438 |
Alopecia totalis | 46.26 | 14.07 | 18 | 86896 | 320 | 56204833 |
Nasopharyngitis | 46.22 | 14.07 | 180 | 86734 | 220779 | 55984374 |
Back pain | 46.01 | 14.07 | 564 | 86350 | 236606 | 55968547 |
Chest discomfort | 45.08 | 14.07 | 284 | 86630 | 98573 | 56106580 |
Drug interaction | 45.08 | 14.07 | 169 | 86745 | 209586 | 55995567 |
Pericardial effusion | 44.98 | 14.07 | 117 | 86797 | 27058 | 56178095 |
Osteonecrosis of jaw | 44.72 | 14.07 | 133 | 86781 | 33225 | 56171928 |
Type 2 diabetes mellitus | 44.62 | 14.07 | 9 | 86905 | 46853 | 56158300 |
Tonsillar disorder | 44.14 | 14.07 | 25 | 86889 | 1065 | 56204088 |
Metastases to the mediastinum | 43.49 | 14.07 | 19 | 86895 | 458 | 56204695 |
Cystoid macular oedema | 43.41 | 14.07 | 28 | 86886 | 1513 | 56203640 |
Desmoplastic small round cell tumour | 43.34 | 14.07 | 15 | 86899 | 188 | 56204965 |
Death | 42.59 | 14.07 | 752 | 86162 | 340674 | 55864479 |
Sedation | 42.17 | 14.07 | 3 | 86911 | 34851 | 56170302 |
Influenza | 42.12 | 14.07 | 51 | 86863 | 95210 | 56109943 |
Onychalgia | 41.36 | 14.07 | 22 | 86892 | 827 | 56204326 |
Cardiac failure | 41.33 | 14.07 | 242 | 86672 | 81851 | 56123302 |
Blood uric acid decreased | 41.02 | 14.07 | 21 | 86893 | 729 | 56204424 |
Suicidal ideation | 40.81 | 14.07 | 19 | 86895 | 57723 | 56147430 |
Nasal congestion | 40.70 | 14.07 | 18 | 86896 | 56352 | 56148801 |
Myelodysplastic syndrome | 39.68 | 14.07 | 82 | 86832 | 16324 | 56188829 |
Excessive eye blinking | 39.65 | 14.07 | 23 | 86891 | 1026 | 56204127 |
Computerised tomogram thorax abnormal | 39.59 | 14.07 | 26 | 86888 | 1449 | 56203704 |
Sepsis | 39.57 | 14.07 | 359 | 86555 | 139481 | 56065672 |
Pulmonary mass | 39.00 | 14.07 | 93 | 86821 | 20377 | 56184776 |
Wheezing | 38.99 | 14.07 | 35 | 86879 | 74991 | 56130162 |
Paraesthesia | 38.95 | 14.07 | 339 | 86575 | 130175 | 56074978 |
Granulocyte count decreased | 38.89 | 14.07 | 22 | 86892 | 935 | 56204218 |
Onychomadesis | 38.85 | 14.07 | 42 | 86872 | 4679 | 56200474 |
Metastases to adrenals | 38.81 | 14.07 | 20 | 86894 | 704 | 56204449 |
Dacryostenosis acquired | 38.78 | 14.07 | 18 | 86896 | 502 | 56204651 |
Acute leukaemia | 38.60 | 14.07 | 23 | 86891 | 1079 | 56204074 |
Odynophagia | 38.44 | 14.07 | 50 | 86864 | 6768 | 56198385 |
Hallucination | 38.25 | 14.07 | 14 | 86900 | 49135 | 56156018 |
Hyperfibrinogenaemia | 38.18 | 14.07 | 9 | 86905 | 22 | 56205131 |
Bone marrow infiltration | 38.14 | 14.07 | 18 | 86896 | 522 | 56204631 |
Nephrolithiasis | 38.09 | 14.07 | 6 | 86908 | 37329 | 56167824 |
Breast pain | 38.05 | 14.07 | 54 | 86860 | 7940 | 56197213 |
Blood creatinine decreased | 37.43 | 14.07 | 43 | 86871 | 5123 | 56200030 |
Cardiac dysfunction | 37.20 | 14.07 | 28 | 86886 | 1942 | 56203211 |
Radiation necrosis | 37.12 | 14.07 | 16 | 86898 | 373 | 56204780 |
Ear infection | 36.99 | 14.07 | 3 | 86911 | 31292 | 56173861 |
Hypocalcaemia | 36.98 | 14.07 | 113 | 86801 | 28647 | 56176506 |
Pregnancy | 36.83 | 14.07 | 4 | 86910 | 33029 | 56172124 |
Adverse event | 36.47 | 14.07 | 20 | 86894 | 55356 | 56149797 |
Mastectomy | 36.35 | 14.07 | 25 | 86889 | 1505 | 56203648 |
Anxiety | 36.27 | 14.07 | 164 | 86750 | 193008 | 56012145 |
Obstructive shock | 36.12 | 14.07 | 9 | 86905 | 30 | 56205123 |
Cataract | 36.00 | 14.07 | 17 | 86897 | 51230 | 56153923 |
Cystitis noninfective | 35.87 | 14.07 | 21 | 86893 | 953 | 56204200 |
Purtscher retinopathy | 35.83 | 14.07 | 7 | 86907 | 3 | 56205150 |
Metastases to chest wall | 35.80 | 14.07 | 17 | 86897 | 500 | 56204653 |
Bradycardia | 35.67 | 14.07 | 31 | 86883 | 67473 | 56137680 |
Drug resistance | 35.60 | 14.07 | 90 | 86824 | 20452 | 56184701 |
COVID-19 | 35.55 | 14.07 | 38 | 86876 | 75020 | 56130133 |
Electrocardiogram QT prolonged | 35.54 | 14.07 | 20 | 86894 | 54568 | 56150585 |
Mucosal infection | 35.30 | 14.07 | 12 | 86902 | 142 | 56205011 |
Eosinophil percentage increased | 35.28 | 14.07 | 21 | 86893 | 983 | 56204170 |
Carotidynia | 35.22 | 14.07 | 12 | 86902 | 143 | 56205010 |
Medication error | 34.78 | 14.07 | 11 | 86903 | 42324 | 56162829 |
Acute interstitial pneumonitis | 34.58 | 14.07 | 18 | 86896 | 647 | 56204506 |
Urticaria | 34.13 | 14.07 | 112 | 86802 | 144564 | 56060589 |
Gait inability | 34.12 | 14.07 | 11 | 86903 | 41807 | 56163346 |
Bronchitis | 33.95 | 14.07 | 77 | 86837 | 112234 | 56092919 |
Systemic scleroderma | 33.84 | 14.07 | 20 | 86894 | 924 | 56204229 |
Ejection fraction | 33.78 | 14.07 | 25 | 86889 | 1690 | 56203463 |
Abortion spontaneous | 33.15 | 14.07 | 13 | 86901 | 43740 | 56161413 |
Intestinal ischaemia | 33.13 | 14.07 | 47 | 86867 | 6908 | 56198245 |
Nail infection | 32.82 | 14.07 | 28 | 86886 | 2325 | 56202828 |
Tumour embolism | 32.76 | 14.07 | 11 | 86903 | 125 | 56205028 |
Alanine aminotransferase increased | 32.63 | 14.07 | 252 | 86662 | 93410 | 56111743 |
Fatigue | 32.46 | 14.07 | 1507 | 85407 | 787045 | 55418108 |
Gastric disorder | 32.42 | 14.07 | 6 | 86908 | 33204 | 56171949 |
Osteolysis | 32.24 | 14.07 | 29 | 86885 | 2584 | 56202569 |
Road traffic accident | 32.13 | 14.07 | 3 | 86911 | 27924 | 56177229 |
Hepatitis B reactivation | 32.09 | 14.07 | 28 | 86886 | 2396 | 56202757 |
Nephritis bacterial | 32.03 | 14.07 | 8 | 86906 | 27 | 56205126 |
Unevaluable event | 31.73 | 14.07 | 17 | 86897 | 47670 | 56157483 |
Bursitis | 31.64 | 14.07 | 3 | 86911 | 27579 | 56177574 |
Coronary artery disease | 31.30 | 14.07 | 5 | 86909 | 30791 | 56174362 |
EGFR gene mutation | 31.28 | 14.07 | 13 | 86901 | 276 | 56204877 |
Osteoporosis | 31.20 | 14.07 | 21 | 86893 | 52031 | 56153122 |
Foetal exposure during pregnancy | 31.17 | 14.07 | 7 | 86907 | 33816 | 56171337 |
Mastitis | 31.08 | 14.07 | 28 | 86886 | 2500 | 56202653 |
Scleroderma renal crisis | 30.94 | 14.07 | 13 | 86901 | 284 | 56204869 |
Dysuria | 30.81 | 14.07 | 111 | 86803 | 30618 | 56174535 |
Swollen tongue | 30.65 | 14.07 | 5 | 86909 | 30319 | 56174834 |
Intentional product misuse | 30.58 | 14.07 | 21 | 86893 | 51483 | 56153670 |
Abdominal pain | 30.46 | 14.07 | 565 | 86349 | 258240 | 55946913 |
Blood alkaline phosphatase increased | 30.39 | 14.07 | 130 | 86784 | 38815 | 56166338 |
International normalised ratio increased | 30.34 | 14.07 | 15 | 86899 | 44026 | 56161127 |
Hyperpyrexia | 30.33 | 14.07 | 31 | 86883 | 3237 | 56201916 |
Peripheral swelling | 30.27 | 14.07 | 225 | 86689 | 234501 | 55970652 |
Oral candidiasis | 30.25 | 14.07 | 80 | 86834 | 18683 | 56186470 |
Hepatic lesion | 30.13 | 14.07 | 35 | 86879 | 4220 | 56200933 |
Gait disturbance | 29.86 | 14.07 | 140 | 86774 | 163181 | 56041972 |
Uterine leiomyosarcoma | 29.69 | 14.07 | 8 | 86906 | 39 | 56205114 |
Gas gangrene | 29.67 | 14.07 | 10 | 86904 | 115 | 56205038 |
Biliary sepsis | 29.61 | 14.07 | 18 | 86896 | 876 | 56204277 |
Troponin I increased | 29.51 | 14.07 | 25 | 86889 | 2056 | 56203097 |
Perforation | 29.45 | 14.07 | 19 | 86895 | 1027 | 56204126 |
Multiple sclerosis | 29.44 | 14.07 | 4 | 86910 | 27798 | 56177355 |
Barotrauma | 29.33 | 14.07 | 11 | 86903 | 176 | 56204977 |
Red blood cell sedimentation rate increased | 29.23 | 14.07 | 10 | 86904 | 36613 | 56168540 |
Metastatic neoplasm | 29.07 | 14.07 | 33 | 86881 | 3880 | 56201273 |
Tremor | 29.07 | 14.07 | 93 | 86821 | 120996 | 56084157 |
Toxic optic neuropathy | 28.99 | 14.07 | 11 | 86903 | 182 | 56204971 |
Vulvovaginal candidiasis | 28.95 | 14.07 | 29 | 86885 | 2957 | 56202196 |
Therapy interrupted | 28.83 | 14.07 | 3 | 86911 | 25622 | 56179531 |
Autonomic neuropathy | 28.82 | 14.07 | 19 | 86895 | 1066 | 56204087 |
Therapy cessation | 28.69 | 14.07 | 4 | 86910 | 27260 | 56177893 |
Gamma-glutamyltransferase increased | 28.58 | 14.07 | 109 | 86805 | 30896 | 56174257 |
Pruritus | 28.54 | 14.07 | 332 | 86582 | 316291 | 55888862 |
Coma | 28.48 | 14.07 | 30 | 86884 | 59625 | 56145528 |
Blood glucose increased | 28.44 | 14.07 | 45 | 86869 | 75106 | 56130047 |
Hypertension | 28.33 | 14.07 | 241 | 86673 | 244037 | 55961116 |
Basal cell carcinoma | 28.26 | 14.07 | 3 | 86911 | 25218 | 56179935 |
Invasive lobular breast carcinoma | 28.25 | 14.07 | 17 | 86897 | 812 | 56204341 |
Vascular fragility | 28.22 | 14.07 | 10 | 86904 | 135 | 56205018 |
Malignant pleural effusion | 28.22 | 14.07 | 26 | 86888 | 2390 | 56202763 |
Folliculitis | 28.14 | 14.07 | 26 | 86888 | 54953 | 56150200 |
Left ventricular dilatation | 27.86 | 14.07 | 14 | 86900 | 467 | 56204686 |
Lactic acidosis | 27.62 | 14.07 | 10 | 86904 | 35336 | 56169817 |
Vein discolouration | 27.40 | 14.07 | 11 | 86903 | 213 | 56204940 |
Systolic dysfunction | 27.25 | 14.07 | 21 | 86893 | 1509 | 56203644 |
Triple negative breast cancer | 27.17 | 14.07 | 11 | 86903 | 218 | 56204935 |
Asthenopia | 27.12 | 14.07 | 24 | 86890 | 2093 | 56203060 |
Dyskinesia | 26.87 | 14.07 | 6 | 86908 | 29102 | 56176051 |
Intestinal perforation | 26.76 | 14.07 | 55 | 86859 | 10904 | 56194249 |
Nasal disorder | 26.74 | 14.07 | 26 | 86888 | 2556 | 56202597 |
Vessel puncture site bruise | 26.45 | 14.07 | 13 | 86901 | 413 | 56204740 |
Tongue coated | 26.42 | 14.07 | 19 | 86895 | 1228 | 56203925 |
Palmar erythema | 26.11 | 14.07 | 21 | 86893 | 1606 | 56203547 |
Septic shock | 26.02 | 14.07 | 172 | 86742 | 60663 | 56144490 |
Subclavian vein thrombosis | 25.96 | 14.07 | 22 | 86892 | 1810 | 56203343 |
Panophthalmitis | 25.89 | 14.07 | 8 | 86906 | 68 | 56205085 |
Vulvovaginal dryness | 25.87 | 14.07 | 25 | 86889 | 2440 | 56202713 |
Full blood count decreased | 25.60 | 14.07 | 3 | 86911 | 23346 | 56181807 |
Irritability | 25.56 | 14.07 | 7 | 86907 | 29581 | 56175572 |
Clostridium bacteraemia | 25.43 | 14.07 | 10 | 86904 | 183 | 56204970 |
Vascular pain | 25.30 | 14.07 | 15 | 86899 | 697 | 56204456 |
Insomnia | 25.16 | 14.07 | 183 | 86731 | 191677 | 56013476 |
Thrombotic microangiopathy | 25.10 | 14.07 | 49 | 86865 | 9362 | 56195791 |
Therapeutic product effect incomplete | 25.06 | 14.07 | 82 | 86832 | 105949 | 56099204 |
Axillary pain | 25.03 | 14.07 | 21 | 86893 | 1704 | 56203449 |
Retinal toxicity | 24.84 | 14.07 | 18 | 86896 | 1178 | 56203975 |
Nervousness | 24.81 | 14.07 | 7 | 86907 | 29008 | 56176145 |
Agitation | 24.76 | 14.07 | 30 | 86884 | 56006 | 56149147 |
Alopecia | 24.63 | 14.07 | 610 | 86304 | 292848 | 55912305 |
Toxicity to various agents | 24.51 | 14.07 | 225 | 86689 | 224339 | 55980814 |
Sclerema | 24.44 | 14.07 | 5 | 86909 | 4 | 56205149 |
Nail bed bleeding | 24.38 | 14.07 | 11 | 86903 | 287 | 56204866 |
Hepatotoxicity | 24.31 | 14.07 | 104 | 86810 | 31049 | 56174104 |
Joint injury | 24.27 | 14.07 | 5 | 86909 | 25649 | 56179504 |
Treatment noncompliance | 24.21 | 14.07 | 10 | 86904 | 32613 | 56172540 |
Hypertransaminasaemia | 24.20 | 14.07 | 33 | 86881 | 4674 | 56200479 |
Acoustic stimulation tests abnormal | 24.06 | 14.07 | 8 | 86906 | 88 | 56205065 |
Injection site haemorrhage | 23.98 | 14.07 | 3 | 86911 | 22198 | 56182955 |
Recurrent cancer | 23.97 | 14.07 | 21 | 86893 | 1807 | 56203346 |
Pneumonia salmonella | 23.92 | 14.07 | 5 | 86909 | 5 | 56205148 |
Menopausal disorder | 23.84 | 14.07 | 7 | 86907 | 49 | 56205104 |
Metastases to thorax | 23.82 | 14.07 | 10 | 86904 | 218 | 56204935 |
Metastases to soft tissue | 23.61 | 14.07 | 9 | 86905 | 151 | 56205002 |
PIK3CA-activated mutation | 23.58 | 14.07 | 16 | 86898 | 942 | 56204211 |
Balance disorder | 23.50 | 14.07 | 52 | 86862 | 76468 | 56128685 |
Pancreatitis | 23.45 | 14.07 | 21 | 86893 | 45059 | 56160094 |
Foot fracture | 23.42 | 14.07 | 3 | 86911 | 21806 | 56183347 |
Pneumocystis jirovecii pneumonia | 23.36 | 14.07 | 65 | 86849 | 15636 | 56189517 |
Full blood count abnormal | 23.35 | 14.07 | 6 | 86908 | 26456 | 56178697 |
Ovarian necrosis | 23.23 | 14.07 | 6 | 86908 | 24 | 56205129 |
Portal hypertension | 23.21 | 14.07 | 28 | 86886 | 3513 | 56201640 |
Depressed level of consciousness | 23.10 | 14.07 | 32 | 86882 | 56401 | 56148752 |
Embolism | 22.96 | 14.07 | 41 | 86873 | 7323 | 56197830 |
Extravasation | 22.95 | 14.07 | 22 | 86892 | 2125 | 56203028 |
Herpes zoster | 22.95 | 14.07 | 52 | 86862 | 75837 | 56129316 |
Salmonella sepsis | 22.82 | 14.07 | 10 | 86904 | 243 | 56204910 |
Folate deficiency | 22.70 | 14.07 | 22 | 86892 | 2155 | 56202998 |
Chronic kidney disease | 22.60 | 14.07 | 19 | 86895 | 42037 | 56163116 |
Pneumothorax | 22.57 | 14.07 | 62 | 86852 | 14805 | 56190348 |
Malaise | 22.57 | 14.07 | 416 | 86498 | 367444 | 55837709 |
Choroidal effusion | 22.44 | 14.07 | 12 | 86902 | 456 | 56204697 |
Joint neoplasm | 22.30 | 14.07 | 7 | 86907 | 63 | 56205090 |
Feeling hot | 22.21 | 14.07 | 125 | 86789 | 41662 | 56163491 |
Eastern Cooperative Oncology Group performance status worsened | 22.18 | 14.07 | 15 | 86899 | 878 | 56204275 |
Femur fracture | 22.05 | 14.07 | 17 | 86897 | 39278 | 56165875 |
Osteitis condensans | 21.98 | 14.07 | 6 | 86908 | 31 | 56205122 |
Blister | 21.92 | 14.07 | 90 | 86824 | 108797 | 56096356 |
Platelet count decreased | 21.91 | 14.07 | 256 | 86658 | 106127 | 56099026 |
Nail bed tenderness | 21.86 | 14.07 | 11 | 86903 | 368 | 56204785 |
Post-traumatic pain | 21.83 | 14.07 | 11 | 86903 | 369 | 56204784 |
Foot deformity | 21.81 | 14.07 | 5 | 86909 | 23820 | 56181333 |
Blood creatine increased | 21.81 | 14.07 | 33 | 86881 | 5140 | 56200013 |
Generalised oedema | 21.54 | 14.07 | 60 | 86854 | 14441 | 56190712 |
Metastases to ovary | 21.53 | 14.07 | 11 | 86903 | 380 | 56204773 |
Accidental overdose | 21.53 | 14.07 | 3 | 86911 | 20458 | 56184695 |
Diabetes mellitus | 21.48 | 14.07 | 30 | 86884 | 52705 | 56152448 |
Soft tissue neoplasm | 21.47 | 14.07 | 7 | 86907 | 72 | 56205081 |
Metastases to nervous system | 21.37 | 14.07 | 6 | 86908 | 35 | 56205118 |
Neck pain | 21.32 | 14.07 | 39 | 86875 | 61516 | 56143637 |
Breast inflammation | 21.28 | 14.07 | 8 | 86906 | 129 | 56205024 |
Acral peeling skin syndrome | 21.27 | 14.07 | 5 | 86909 | 12 | 56205141 |
Malignant neoplasm of pleura | 21.22 | 14.07 | 7 | 86907 | 75 | 56205078 |
Lymphadenopathy | 21.21 | 14.07 | 109 | 86805 | 35099 | 56170054 |
Surgery | 21.00 | 14.07 | 12 | 86902 | 32474 | 56172679 |
Muscle spasticity | 20.83 | 14.07 | 3 | 86911 | 19957 | 56185196 |
Monocyte count decreased | 20.80 | 14.07 | 20 | 86894 | 1940 | 56203213 |
Blood pressure fluctuation | 20.76 | 14.07 | 19 | 86895 | 40341 | 56164812 |
Lymphangitis | 20.70 | 14.07 | 14 | 86900 | 820 | 56204333 |
Hyperkalaemia | 20.66 | 14.07 | 29 | 86885 | 50836 | 56154317 |
Red cell distribution width increased | 20.64 | 14.07 | 45 | 86869 | 9295 | 56195858 |
Hypoglycaemia | 20.57 | 14.07 | 34 | 86880 | 55781 | 56149372 |
Neuromuscular toxicity | 20.57 | 14.07 | 8 | 86906 | 142 | 56205011 |
Lung infiltration | 20.56 | 14.07 | 57 | 86857 | 13681 | 56191472 |
Hiccups | 20.56 | 14.07 | 20 | 86894 | 1968 | 56203185 |
Eye pain | 20.51 | 14.07 | 11 | 86903 | 30836 | 56174317 |
Vasculitis | 20.47 | 14.07 | 60 | 86854 | 14863 | 56190290 |
Hip fracture | 20.45 | 14.07 | 8 | 86906 | 26965 | 56178188 |
Transaminases | 20.43 | 14.07 | 7 | 86907 | 85 | 56205068 |
Hypothalamo-pituitary disorder | 20.42 | 14.07 | 13 | 86901 | 687 | 56204466 |
Epidermolysis | 20.34 | 14.07 | 9 | 86905 | 224 | 56204929 |
Mucosal disorder | 20.24 | 14.07 | 20 | 86894 | 2006 | 56203147 |
Chromosomal mutation | 20.22 | 14.07 | 5 | 86909 | 16 | 56205137 |
Chronic obstructive pulmonary disease | 20.22 | 14.07 | 36 | 86878 | 57379 | 56147774 |
Cough | 20.22 | 14.07 | 535 | 86379 | 259426 | 55945727 |
Miller Fisher syndrome | 20.21 | 14.07 | 7 | 86907 | 88 | 56205065 |
Leukaemia cutis | 20.21 | 14.07 | 7 | 86907 | 88 | 56205065 |
Acute respiratory distress syndrome | 20.14 | 14.07 | 77 | 86837 | 21849 | 56183304 |
White blood cell count abnormal | 20.03 | 14.07 | 34 | 86880 | 5833 | 56199320 |
Pituitary tumour | 20.03 | 14.07 | 14 | 86900 | 865 | 56204288 |
Hypoalbuminaemia | 20.02 | 14.07 | 48 | 86866 | 10551 | 56194602 |
Leukocytosis | 19.80 | 14.07 | 81 | 86833 | 23710 | 56181443 |
Hepatic failure | 19.71 | 14.07 | 103 | 86811 | 33383 | 56171770 |
Kidney infection | 19.69 | 14.07 | 4 | 86910 | 20721 | 56184432 |
Muscle necrosis | 19.57 | 14.07 | 12 | 86902 | 593 | 56204560 |
Chemical peritonitis | 19.52 | 14.07 | 7 | 86907 | 98 | 56205055 |
Chemotherapy | 19.45 | 14.07 | 17 | 86897 | 1458 | 56203695 |
Breast oedema | 19.42 | 14.07 | 6 | 86908 | 51 | 56205102 |
Aggression | 19.40 | 14.07 | 5 | 86909 | 22001 | 56183152 |
Seroma | 19.34 | 14.07 | 19 | 86895 | 1892 | 56203261 |
Retinitis pigmentosa | 19.33 | 14.07 | 7 | 86907 | 101 | 56205052 |
Peritonitis | 19.30 | 14.07 | 62 | 86852 | 16140 | 56189013 |
General physical health deterioration | 19.23 | 14.07 | 369 | 86545 | 169641 | 56035512 |
Paralysis recurrent laryngeal nerve | 19.22 | 14.07 | 6 | 86908 | 53 | 56205100 |
Paraparesis | 19.22 | 14.07 | 20 | 86894 | 2133 | 56203020 |
Retinal detachment | 19.20 | 14.07 | 32 | 86882 | 5409 | 56199744 |
Congenital syphilitic osteochondritis | 19.16 | 14.07 | 5 | 86909 | 21 | 56205132 |
Distichiasis | 19.16 | 14.07 | 5 | 86909 | 21 | 56205132 |
Ear pain | 19.14 | 14.07 | 12 | 86902 | 30878 | 56174275 |
Dizziness | 19.03 | 14.07 | 439 | 86475 | 375701 | 55829452 |
Overflow diarrhoea | 19.02 | 14.07 | 7 | 86907 | 106 | 56205047 |
Chills | 18.99 | 14.07 | 242 | 86672 | 102362 | 56102791 |
Intervertebral disc protrusion | 18.99 | 14.07 | 5 | 86909 | 21689 | 56183464 |
Neutrophil count abnormal | 18.97 | 14.07 | 22 | 86892 | 2648 | 56202505 |
Skin laceration | 18.92 | 14.07 | 4 | 86910 | 20152 | 56185001 |
Gastrointestinal perforation | 18.88 | 14.07 | 24 | 86890 | 3175 | 56201978 |
Drug ineffective for unapproved indication | 18.87 | 14.07 | 8 | 86906 | 25685 | 56179468 |
Tympanic membrane disorder | 18.82 | 14.07 | 8 | 86906 | 180 | 56204973 |
Dysarthria | 18.75 | 14.07 | 20 | 86894 | 39530 | 56165623 |
Phlebitis | 18.61 | 14.07 | 34 | 86880 | 6182 | 56198971 |
Hydrothorax | 18.60 | 14.07 | 13 | 86901 | 803 | 56204350 |
Onychoclasis | 18.59 | 14.07 | 32 | 86882 | 5553 | 56199600 |
Gastritis | 18.57 | 14.07 | 104 | 86810 | 34598 | 56170555 |
Vulvitis | 18.51 | 14.07 | 9 | 86905 | 279 | 56204874 |
Hydrocephalus | 18.49 | 14.07 | 30 | 86884 | 4959 | 56200194 |
Aspartate aminotransferase increased | 18.46 | 14.07 | 202 | 86712 | 82400 | 56122753 |
Inflammatory carcinoma of the breast | 18.38 | 14.07 | 6 | 86908 | 62 | 56205091 |
Granulocytopenia | 18.29 | 14.07 | 31 | 86883 | 5313 | 56199840 |
Appendiceal abscess | 18.19 | 14.07 | 8 | 86906 | 196 | 56204957 |
Hyperchlorhydria | 18.13 | 14.07 | 17 | 86897 | 1598 | 56203555 |
Underdose | 18.09 | 14.07 | 7 | 86907 | 23750 | 56181403 |
Vena cava thrombosis | 18.07 | 14.07 | 19 | 86895 | 2050 | 56203103 |
Non-small cell lung cancer | 17.84 | 14.07 | 25 | 86889 | 3633 | 56201520 |
Blood pressure increased | 17.83 | 14.07 | 141 | 86773 | 145035 | 56060118 |
Merycism | 17.75 | 14.07 | 8 | 86906 | 208 | 56204945 |
No adverse event | 17.69 | 14.07 | 18 | 86896 | 36356 | 56168797 |
Acquired gene mutation | 17.63 | 14.07 | 13 | 86901 | 874 | 56204279 |
Staphylococcal impetigo | 17.52 | 14.07 | 4 | 86910 | 8 | 56205145 |
Vaginal prolapse | 17.49 | 14.07 | 10 | 86904 | 434 | 56204719 |
Product quality issue | 17.47 | 14.07 | 14 | 86900 | 31722 | 56173431 |
Metastases to muscle | 17.42 | 14.07 | 7 | 86907 | 136 | 56205017 |
Meibomian gland dysfunction | 17.32 | 14.07 | 7 | 86907 | 138 | 56205015 |
Stress | 17.30 | 14.07 | 41 | 86873 | 58869 | 56146284 |
Gallbladder disorder | 17.20 | 14.07 | 3 | 86911 | 17331 | 56187822 |
Axillary vein thrombosis | 17.10 | 14.07 | 9 | 86905 | 331 | 56204822 |
Neoplasm recurrence | 17.00 | 14.07 | 20 | 86894 | 2444 | 56202709 |
Oral pain | 16.97 | 14.07 | 83 | 86831 | 26210 | 56178943 |
Clostridial infection | 16.90 | 14.07 | 26 | 86888 | 4109 | 56201044 |
Seasonal allergy | 16.89 | 14.07 | 3 | 86911 | 17105 | 56188048 |
Metastases to uterus | 16.73 | 14.07 | 6 | 86908 | 84 | 56205069 |
Abdominal rigidity | 16.69 | 14.07 | 17 | 86897 | 1768 | 56203385 |
Injection site rash | 16.69 | 14.07 | 3 | 86911 | 16955 | 56188198 |
Emotional distress | 16.55 | 14.07 | 13 | 86901 | 29750 | 56175403 |
Memory impairment | 16.52 | 14.07 | 73 | 86841 | 86484 | 56118669 |
Pain in extremity | 16.51 | 14.07 | 342 | 86572 | 297089 | 55908064 |
Skin reaction | 16.49 | 14.07 | 51 | 86863 | 13012 | 56192141 |
Cannabinoid hyperemesis syndrome | 16.45 | 14.07 | 5 | 86909 | 40 | 56205113 |
ALK gene rearrangement positive | 16.43 | 14.07 | 3 | 86911 | 0 | 56205153 |
Astringent therapy | 16.43 | 14.07 | 3 | 86911 | 0 | 56205153 |
Labia enlarged | 16.43 | 14.07 | 3 | 86911 | 0 | 56205153 |
Pulmonary embolism | 16.30 | 14.07 | 244 | 86670 | 106880 | 56098273 |
Therapy non-responder | 16.25 | 14.07 | 45 | 86869 | 61310 | 56143843 |
Limb injury | 16.25 | 14.07 | 7 | 86907 | 22263 | 56182890 |
Clostridium difficile infection | 16.24 | 14.07 | 84 | 86830 | 27114 | 56178039 |
Dandy-Walker syndrome | 16.23 | 14.07 | 6 | 86908 | 92 | 56205061 |
Product administration error | 16.22 | 14.07 | 6 | 86908 | 20923 | 56184230 |
Sleep disorder | 16.21 | 14.07 | 52 | 86862 | 67611 | 56137542 |
Hormone receptor positive breast cancer | 16.17 | 14.07 | 10 | 86904 | 502 | 56204651 |
Tumour marker increased | 16.17 | 14.07 | 26 | 86888 | 4267 | 56200886 |
Laboratory test abnormal | 16.14 | 14.07 | 9 | 86905 | 24686 | 56180467 |
Pulmonary hypertension | 16.14 | 14.07 | 19 | 86895 | 35925 | 56169228 |
Rash follicular | 16.13 | 14.07 | 5 | 86909 | 43 | 56205110 |
Herpes simplex sepsis | 16.13 | 14.07 | 5 | 86909 | 43 | 56205110 |
Frequent bowel movements | 15.96 | 14.07 | 3 | 86911 | 16421 | 56188732 |
Hyperaemia | 15.94 | 14.07 | 18 | 86896 | 2104 | 56203049 |
Cytotoxic oedema | 15.94 | 14.07 | 7 | 86907 | 171 | 56204982 |
Pseudomembranous colitis | 15.92 | 14.07 | 21 | 86893 | 2882 | 56202271 |
Transient ischaemic attack | 15.89 | 14.07 | 17 | 86897 | 33560 | 56171593 |
Prescribed underdose | 15.82 | 14.07 | 6 | 86908 | 20611 | 56184542 |
Pneumonia aspiration | 15.80 | 14.07 | 16 | 86898 | 32395 | 56172758 |
Entropion | 15.74 | 14.07 | 5 | 86909 | 47 | 56205106 |
Necrosis | 15.73 | 14.07 | 28 | 86886 | 4988 | 56200165 |
Grip strength decreased | 15.73 | 14.07 | 3 | 86911 | 16253 | 56188900 |
Dysaesthesia | 15.60 | 14.07 | 25 | 86889 | 4091 | 56201062 |
Cardiac tamponade | 15.58 | 14.07 | 26 | 86888 | 4400 | 56200753 |
Caesarean section | 15.51 | 14.07 | 3 | 86911 | 16088 | 56189065 |
Coating in mouth | 15.50 | 14.07 | 7 | 86907 | 183 | 56204970 |
Radiation pneumonitis | 15.43 | 14.07 | 15 | 86899 | 1474 | 56203679 |
Hypervolaemia | 15.42 | 14.07 | 11 | 86903 | 26447 | 56178706 |
Colitis ischaemic | 15.42 | 14.07 | 42 | 86872 | 9978 | 56195175 |
Vasogenic cerebral oedema | 15.38 | 14.07 | 10 | 86904 | 548 | 56204605 |
Viral infection | 15.32 | 14.07 | 16 | 86898 | 31930 | 56173223 |
Pleural disorder | 15.31 | 14.07 | 10 | 86904 | 552 | 56204601 |
Mouth ulceration | 15.31 | 14.07 | 88 | 86826 | 29552 | 56175601 |
Anal erythema | 15.26 | 14.07 | 7 | 86907 | 190 | 56204963 |
Vision blurred | 15.20 | 14.07 | 71 | 86843 | 82872 | 56122281 |
Sarcoidosis | 15.19 | 14.07 | 29 | 86885 | 5451 | 56199702 |
Soft tissue infection | 15.18 | 14.07 | 17 | 86897 | 1970 | 56203183 |
Cardiac arrest | 15.17 | 14.07 | 75 | 86839 | 86239 | 56118914 |
Vagus nerve disorder | 15.15 | 14.07 | 6 | 86908 | 112 | 56205041 |
Joint dislocation | 15.07 | 14.07 | 3 | 86911 | 15770 | 56189383 |
Dermatitis bullous | 15.07 | 14.07 | 35 | 86879 | 7538 | 56197615 |
Arachnoid cyst | 15.06 | 14.07 | 7 | 86907 | 196 | 56204957 |
Adenocarcinoma | 15.04 | 14.07 | 20 | 86894 | 2765 | 56202388 |
Sarcoma | 15.01 | 14.07 | 10 | 86904 | 571 | 56204582 |
Necrotising myositis | 14.99 | 14.07 | 9 | 86905 | 428 | 56204725 |
Peripheral motor neuropathy | 14.94 | 14.07 | 15 | 86899 | 1533 | 56203620 |
Upper limb fracture | 14.93 | 14.07 | 4 | 86910 | 17151 | 56188002 |
Monocytopenia | 14.80 | 14.07 | 5 | 86909 | 58 | 56205095 |
Hypomagnesaemia | 14.76 | 14.07 | 77 | 86837 | 24938 | 56180215 |
Disorientation | 14.74 | 14.07 | 21 | 86893 | 36592 | 56168561 |
Atypical pneumonia | 14.72 | 14.07 | 24 | 86890 | 3984 | 56201169 |
Faeces discoloured | 14.72 | 14.07 | 4 | 86910 | 16992 | 56188161 |
Appendicitis | 14.72 | 14.07 | 34 | 86880 | 7298 | 56197855 |
Arteritis | 14.69 | 14.07 | 10 | 86904 | 592 | 56204561 |
Naevus haemorrhage | 14.63 | 14.07 | 6 | 86908 | 123 | 56205030 |
Urogenital prolapse | 14.60 | 14.07 | 4 | 86910 | 21 | 56205132 |
Carcinoembryonic antigen increased | 14.43 | 14.07 | 15 | 86899 | 1597 | 56203556 |
Subretinal hyperreflective exudation | 14.35 | 14.07 | 3 | 86911 | 3 | 56205150 |
Non-small cell lung cancer metastatic | 14.35 | 14.07 | 10 | 86904 | 615 | 56204538 |
Therapy responder | 14.23 | 14.07 | 8 | 86906 | 336 | 56204817 |
Left ventricular enlargement | 14.21 | 14.07 | 5 | 86909 | 66 | 56205087 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1225.18 | 16.00 | 915 | 38907 | 78083 | 31579439 |
Febrile neutropenia | 573.93 | 16.00 | 734 | 39088 | 121115 | 31536407 |
Osteonecrosis of jaw | 540.51 | 16.00 | 310 | 39512 | 16761 | 31640761 |
Prostatic specific antigen increased | 407.61 | 16.00 | 238 | 39584 | 13300 | 31644222 |
Hormone-refractory prostate cancer | 380.25 | 16.00 | 123 | 39699 | 1544 | 31655978 |
Neutropenia | 361.45 | 16.00 | 638 | 39184 | 139726 | 31517796 |
Disease progression | 360.76 | 16.00 | 503 | 39319 | 89961 | 31567561 |
Metastases to bone | 356.69 | 16.00 | 202 | 39620 | 10646 | 31646876 |
Prostate cancer metastatic | 348.85 | 16.00 | 164 | 39658 | 5840 | 31651682 |
Diarrhoea | 295.45 | 16.00 | 1040 | 38782 | 351369 | 31306153 |
Mucosal inflammation | 203.08 | 16.00 | 233 | 39589 | 34194 | 31623328 |
Metastases to lymph nodes | 177.81 | 16.00 | 93 | 39729 | 4175 | 31653347 |
Neutropenic sepsis | 159.63 | 16.00 | 129 | 39693 | 12250 | 31645272 |
Stomatitis | 157.87 | 16.00 | 220 | 39602 | 39218 | 31618304 |
Interstitial lung disease | 156.04 | 16.00 | 278 | 39544 | 61125 | 31596397 |
Neutrophil count decreased | 154.13 | 16.00 | 237 | 39585 | 46157 | 31611365 |
Neoplasm progression | 143.42 | 16.00 | 151 | 39671 | 20121 | 31637401 |
Onycholysis | 142.05 | 16.00 | 46 | 39776 | 579 | 31656943 |
Alopecia | 140.84 | 16.00 | 151 | 39671 | 20544 | 31636978 |
Leukopenia | 140.78 | 16.00 | 257 | 39565 | 57571 | 31599951 |
Pneumonitis | 137.88 | 16.00 | 181 | 39641 | 30471 | 31627051 |
Metastases to lung | 124.18 | 16.00 | 95 | 39727 | 8327 | 31649195 |
Prostate cancer | 119.16 | 16.00 | 188 | 39634 | 37413 | 31620109 |
Metastases to liver | 108.70 | 16.00 | 105 | 39717 | 12622 | 31644900 |
Palmar-plantar erythrodysaesthesia syndrome | 107.15 | 16.00 | 114 | 39708 | 15369 | 31642153 |
Dehydration | 105.35 | 16.00 | 359 | 39463 | 118752 | 31538770 |
Haematotoxicity | 101.93 | 16.00 | 79 | 39743 | 7058 | 31650464 |
Anaemia | 101.40 | 16.00 | 532 | 39290 | 212990 | 31444532 |
Nausea | 91.48 | 16.00 | 680 | 39142 | 307267 | 31350255 |
Product dose omission issue | 89.63 | 16.00 | 13 | 39809 | 105573 | 31551949 |
Metastases to central nervous system | 88.88 | 16.00 | 75 | 39747 | 7561 | 31649961 |
Drug interaction | 88.71 | 16.00 | 79 | 39743 | 208464 | 31449058 |
Skin toxicity | 86.87 | 16.00 | 58 | 39764 | 4101 | 31653421 |
Fall | 83.41 | 16.00 | 67 | 39755 | 186022 | 31471500 |
Portal venous gas | 80.16 | 16.00 | 26 | 39796 | 329 | 31657193 |
Bone marrow failure | 79.15 | 16.00 | 133 | 39689 | 27875 | 31629647 |
Septic shock | 78.48 | 16.00 | 221 | 39601 | 65937 | 31591585 |
Hypocalcaemia | 78.21 | 16.00 | 116 | 39706 | 21862 | 31635660 |
White blood cell count decreased | 75.08 | 16.00 | 261 | 39561 | 87137 | 31570385 |
Non-small cell lung cancer | 73.30 | 16.00 | 52 | 39770 | 4057 | 31653465 |
Decreased appetite | 71.38 | 16.00 | 380 | 39442 | 152837 | 31504685 |
Neuropathy peripheral | 68.54 | 16.00 | 230 | 39592 | 75419 | 31582103 |
Peripheral sensory neuropathy | 63.36 | 16.00 | 57 | 39765 | 6258 | 31651264 |
Bacterial translocation | 62.16 | 16.00 | 21 | 39801 | 304 | 31657218 |
Recall phenomenon | 61.26 | 16.00 | 24 | 39798 | 540 | 31656982 |
Overdose | 60.16 | 16.00 | 16 | 39806 | 84648 | 31572874 |
Headache | 58.16 | 16.00 | 88 | 39734 | 183564 | 31473958 |
Bone pain | 57.49 | 16.00 | 94 | 39728 | 19257 | 31638265 |
Osteonecrosis | 56.32 | 16.00 | 78 | 39744 | 13806 | 31643716 |
Plasma cell myeloma | 55.57 | 16.00 | 4 | 39818 | 56527 | 31600995 |
Nasopharyngitis | 55.52 | 16.00 | 7 | 39815 | 63238 | 31594284 |
Tremor | 55.14 | 16.00 | 14 | 39808 | 76406 | 31581116 |
Pleural effusion | 54.44 | 16.00 | 212 | 39610 | 74708 | 31582814 |
Polyneuropathy | 54.09 | 16.00 | 74 | 39748 | 12948 | 31644574 |
Nail disorder | 53.54 | 16.00 | 32 | 39790 | 1863 | 31655659 |
Oesophagobronchial fistula | 53.09 | 16.00 | 16 | 39806 | 156 | 31657366 |
General physical health deterioration | 52.53 | 16.00 | 281 | 39541 | 113154 | 31544368 |
Oesophageal fistula | 52.06 | 16.00 | 17 | 39805 | 220 | 31657302 |
Vomiting | 51.92 | 16.00 | 468 | 39354 | 223505 | 31434017 |
Metastasis | 51.49 | 16.00 | 40 | 39782 | 3584 | 31653938 |
Fatigue | 49.18 | 16.00 | 639 | 39183 | 334567 | 31322955 |
Bone lesion | 48.87 | 16.00 | 35 | 39787 | 2772 | 31654750 |
Pulmonary toxicity | 47.11 | 16.00 | 45 | 39777 | 5332 | 31652190 |
Weight increased | 46.54 | 16.00 | 23 | 39799 | 82924 | 31574598 |
Agitation | 45.18 | 16.00 | 7 | 39815 | 54162 | 31603360 |
Reproductive toxicity | 44.90 | 16.00 | 9 | 39813 | 9 | 31657513 |
Therapy partial responder | 44.83 | 16.00 | 48 | 39774 | 6514 | 31651008 |
Urinary tract toxicity | 44.42 | 16.00 | 9 | 39813 | 10 | 31657512 |
Radiation skin injury | 43.48 | 16.00 | 20 | 39802 | 676 | 31656846 |
Neutropenic colitis | 43.31 | 16.00 | 32 | 39790 | 2660 | 31654862 |
Prostate cancer recurrent | 43.22 | 16.00 | 22 | 39800 | 932 | 31656590 |
Depression | 42.79 | 16.00 | 31 | 39791 | 90784 | 31566738 |
Pyrexia | 42.76 | 16.00 | 575 | 39247 | 303265 | 31354257 |
Colon cancer stage III | 42.00 | 16.00 | 14 | 39808 | 194 | 31657328 |
Asthma | 41.92 | 16.00 | 3 | 39819 | 42608 | 31614914 |
Onychomadesis | 41.63 | 16.00 | 18 | 39804 | 524 | 31656998 |
Rhabdomyolysis | 41.55 | 16.00 | 14 | 39808 | 63567 | 31593955 |
Insomnia | 40.15 | 16.00 | 36 | 39786 | 94800 | 31562722 |
Metastases to skin | 38.61 | 16.00 | 16 | 39806 | 418 | 31657104 |
Lung adenocarcinoma | 38.44 | 16.00 | 37 | 39785 | 4425 | 31653097 |
Neoplasm recurrence | 38.28 | 16.00 | 27 | 39795 | 2087 | 31655435 |
Rheumatoid arthritis | 38.05 | 16.00 | 7 | 39815 | 47802 | 31609720 |
Gastric perforation | 37.85 | 16.00 | 28 | 39794 | 2331 | 31655191 |
Cardiac failure congestive | 37.52 | 16.00 | 27 | 39795 | 79360 | 31578162 |
Disseminated intravascular coagulation | 36.37 | 16.00 | 80 | 39742 | 20457 | 31637065 |
Paronychia | 36.20 | 16.00 | 31 | 39791 | 3187 | 31654335 |
Musculoskeletal stiffness | 35.24 | 16.00 | 5 | 39817 | 41320 | 31616202 |
Erythema | 35.05 | 16.00 | 196 | 39626 | 80209 | 31577313 |
Acute motor-sensory axonal neuropathy | 34.83 | 16.00 | 11 | 39811 | 127 | 31657395 |
Gastrointestinal toxicity | 34.28 | 16.00 | 26 | 39796 | 2248 | 31655274 |
Exposed bone in jaw | 33.99 | 16.00 | 22 | 39800 | 1475 | 31656047 |
Dermatitis | 33.11 | 16.00 | 47 | 39775 | 8509 | 31649013 |
Somnolence | 33.05 | 16.00 | 46 | 39776 | 99399 | 31558123 |
Hallucination | 32.52 | 16.00 | 9 | 39813 | 46401 | 31611121 |
Myocardial infarction | 32.47 | 16.00 | 58 | 39764 | 113396 | 31544126 |
Pneumatosis intestinalis | 32.40 | 16.00 | 31 | 39791 | 3680 | 31653842 |
Second primary malignancy | 32.33 | 16.00 | 42 | 39780 | 6990 | 31650532 |
Metastases to spine | 32.03 | 16.00 | 25 | 39797 | 2255 | 31655267 |
Metastases to soft tissue | 31.89 | 16.00 | 12 | 39810 | 241 | 31657281 |
Inappropriate schedule of product administration | 31.82 | 16.00 | 12 | 39810 | 50811 | 31606711 |
Metastases to meninges | 31.76 | 16.00 | 20 | 39802 | 1279 | 31656243 |
Necrotising retinitis | 31.75 | 16.00 | 17 | 39805 | 800 | 31656722 |
Carbohydrate antigen 15-3 increased | 31.67 | 16.00 | 9 | 39813 | 70 | 31657452 |
Bone disorder | 31.54 | 16.00 | 38 | 39784 | 5861 | 31651661 |
Nail toxicity | 31.50 | 16.00 | 8 | 39814 | 38 | 31657484 |
Drug hypersensitivity | 31.39 | 16.00 | 27 | 39795 | 72572 | 31584950 |
Pneumothorax | 31.23 | 16.00 | 67 | 39755 | 16843 | 31640679 |
Joint swelling | 31.22 | 16.00 | 14 | 39808 | 53417 | 31604105 |
Hypophagia | 30.50 | 16.00 | 78 | 39744 | 21964 | 31635558 |
Dizziness | 30.24 | 16.00 | 138 | 39684 | 199009 | 31458513 |
Metastases to pleura | 30.05 | 16.00 | 13 | 39809 | 379 | 31657143 |
Injection site pain | 29.98 | 16.00 | 4 | 39818 | 34630 | 31622892 |
Suicidal ideation | 29.69 | 16.00 | 5 | 39817 | 36401 | 31621121 |
Flushing | 29.40 | 16.00 | 94 | 39728 | 30034 | 31627488 |
Anxiety | 29.37 | 16.00 | 43 | 39779 | 90990 | 31566532 |
Urticaria | 29.28 | 16.00 | 18 | 39804 | 57499 | 31600023 |
Death | 29.22 | 16.00 | 624 | 39198 | 359945 | 31297577 |
Intestinal ischaemia | 29.20 | 16.00 | 40 | 39782 | 7005 | 31650517 |
Muscle spasms | 28.82 | 16.00 | 26 | 39796 | 68292 | 31589230 |
Eubacterium infection | 28.40 | 16.00 | 5 | 39817 | 0 | 31657522 |
Karnofsky scale worsened | 28.40 | 16.00 | 5 | 39817 | 0 | 31657522 |
Gastrointestinal ischaemia | 28.34 | 16.00 | 10 | 39812 | 166 | 31657356 |
Blood pressure increased | 28.34 | 16.00 | 35 | 39787 | 79598 | 31577924 |
Cerebrovascular accident | 27.18 | 16.00 | 36 | 39786 | 79448 | 31578074 |
Colitis | 27.16 | 16.00 | 99 | 39723 | 33788 | 31623734 |
Macroenzyme creatine kinase | 26.31 | 16.00 | 6 | 39816 | 16 | 31657506 |
Superior mesenteric artery syndrome | 26.10 | 16.00 | 8 | 39814 | 83 | 31657439 |
Mediastinitis | 26.07 | 16.00 | 14 | 39808 | 663 | 31656859 |
Carotid artery aneurysm | 26.06 | 16.00 | 7 | 39815 | 43 | 31657479 |
Drug ineffective | 25.98 | 16.00 | 346 | 39476 | 395227 | 31262295 |
Contusion | 25.93 | 16.00 | 5 | 39817 | 33023 | 31624499 |
Sinusitis | 25.93 | 16.00 | 7 | 39815 | 36689 | 31620833 |
Atypical haemolytic uraemic syndrome | 25.56 | 16.00 | 10 | 39812 | 224 | 31657298 |
Acute febrile neutrophilic dermatosis | 25.34 | 16.00 | 17 | 39805 | 1211 | 31656311 |
Pancreatitis viral | 24.95 | 16.00 | 5 | 39817 | 5 | 31657517 |
Blood glucose increased | 24.88 | 16.00 | 24 | 39798 | 61059 | 31596463 |
Nicotinic acid deficiency | 24.83 | 16.00 | 8 | 39814 | 99 | 31657423 |
Hypophosphataemia | 24.80 | 16.00 | 41 | 39781 | 8473 | 31649049 |
Rash | 24.77 | 16.00 | 150 | 39672 | 201336 | 31456186 |
Dysphagia | 24.72 | 16.00 | 140 | 39682 | 57536 | 31599986 |
Nail ridging | 24.06 | 16.00 | 8 | 39814 | 110 | 31657412 |
Tooth extraction | 23.09 | 16.00 | 28 | 39794 | 4347 | 31653175 |
Transdifferentiation of neoplasm | 22.98 | 16.00 | 7 | 39815 | 71 | 31657451 |
Hyponatraemia | 22.89 | 16.00 | 165 | 39657 | 73634 | 31583888 |
Cholangitis sclerosing | 22.73 | 16.00 | 16 | 39806 | 1233 | 31656289 |
Chemotherapy | 22.52 | 16.00 | 12 | 39810 | 559 | 31656963 |
Pharyngeal abscess | 22.45 | 16.00 | 11 | 39811 | 429 | 31657093 |
Osteoradionecrosis | 22.39 | 16.00 | 7 | 39815 | 78 | 31657444 |
Agranulocytosis | 22.30 | 16.00 | 68 | 39754 | 21179 | 31636343 |
Hydronephrosis | 21.97 | 16.00 | 41 | 39781 | 9320 | 31648202 |
Oesophagitis | 21.57 | 16.00 | 48 | 39774 | 12368 | 31645154 |
Tracheal fistula | 21.48 | 16.00 | 7 | 39815 | 90 | 31657432 |
Feeling abnormal | 21.40 | 16.00 | 24 | 39798 | 56978 | 31600544 |
Arthralgia | 21.18 | 16.00 | 108 | 39714 | 151316 | 31506206 |
Aorto-oesophageal fistula | 21.07 | 16.00 | 6 | 39816 | 47 | 31657475 |
Tracheal stenosis | 20.97 | 16.00 | 8 | 39814 | 167 | 31657355 |
Myelosuppression | 20.85 | 16.00 | 53 | 39769 | 14867 | 31642655 |
Bronchial fistula | 20.80 | 16.00 | 8 | 39814 | 171 | 31657351 |
Acute respiratory distress syndrome | 20.78 | 16.00 | 73 | 39749 | 24467 | 31633055 |
Tumour pain | 20.50 | 16.00 | 14 | 39808 | 1027 | 31656495 |
Free prostate-specific antigen positive | 20.49 | 16.00 | 4 | 39818 | 3 | 31657519 |
Seizure | 20.46 | 16.00 | 61 | 39761 | 99707 | 31557815 |
Ischaemic enteritis | 20.38 | 16.00 | 5 | 39817 | 20 | 31657502 |
Hypokalaemia | 20.36 | 16.00 | 126 | 39696 | 53448 | 31604074 |
Blood creatine phosphokinase increased | 20.19 | 16.00 | 14 | 39808 | 41960 | 31615562 |
Metastases to bladder | 20.05 | 16.00 | 6 | 39816 | 57 | 31657465 |
Abnormal behaviour | 20.04 | 16.00 | 3 | 39819 | 23825 | 31633697 |
Delusion of grandeur | 19.98 | 16.00 | 12 | 39810 | 705 | 31656817 |
Trigeminal nerve paresis | 19.96 | 16.00 | 4 | 39818 | 4 | 31657518 |
Infusion site plaque | 19.96 | 16.00 | 4 | 39818 | 4 | 31657518 |
Capillary leak syndrome | 19.86 | 16.00 | 18 | 39804 | 1995 | 31655527 |
Gastrointestinal necrosis | 19.79 | 16.00 | 22 | 39800 | 3112 | 31654410 |
Hospitalisation | 19.78 | 16.00 | 20 | 39802 | 49787 | 31607735 |
Sarcoma | 19.77 | 16.00 | 10 | 39812 | 418 | 31657104 |
Polyserositis | 19.63 | 16.00 | 8 | 39814 | 200 | 31657322 |
Dacryostenosis acquired | 19.60 | 16.00 | 8 | 39814 | 201 | 31657321 |
Laryngeal oedema | 19.32 | 16.00 | 22 | 39800 | 3195 | 31654327 |
Periorbital disorder | 19.00 | 16.00 | 5 | 39817 | 28 | 31657494 |
Irritability | 18.98 | 16.00 | 3 | 39819 | 22886 | 31634636 |
Scleroderma | 18.85 | 16.00 | 15 | 39807 | 1392 | 31656130 |
Metastases to peritoneum | 18.69 | 16.00 | 16 | 39806 | 1644 | 31655878 |
Malignant sweat gland neoplasm | 18.69 | 16.00 | 4 | 39818 | 7 | 31657515 |
Disturbance in attention | 18.49 | 16.00 | 3 | 39819 | 22447 | 31635075 |
Aneurysm ruptured | 18.48 | 16.00 | 10 | 39812 | 481 | 31657041 |
Oral pain | 18.38 | 16.00 | 39 | 39783 | 9726 | 31647796 |
Coating in mouth | 18.35 | 16.00 | 6 | 39816 | 78 | 31657444 |
Metastases to the mediastinum | 18.34 | 16.00 | 8 | 39814 | 238 | 31657284 |
Psoriasis | 18.28 | 16.00 | 19 | 39803 | 46700 | 31610822 |
Coma | 18.15 | 16.00 | 15 | 39807 | 41135 | 31616387 |
Memory impairment | 17.96 | 16.00 | 13 | 39809 | 38117 | 31619405 |
Nephrolithiasis | 17.89 | 16.00 | 6 | 39816 | 27333 | 31630189 |
Lacrimation increased | 17.85 | 16.00 | 33 | 39789 | 7449 | 31650073 |
Enteritis | 17.81 | 16.00 | 32 | 39790 | 7067 | 31650455 |
Acute interstitial pneumonitis | 17.80 | 16.00 | 9 | 39813 | 376 | 31657146 |
Pruritus | 17.65 | 16.00 | 89 | 39733 | 125078 | 31532444 |
Adenocarcinoma | 17.64 | 16.00 | 16 | 39806 | 1775 | 31655747 |
Malignant neoplasm of pleura | 17.60 | 16.00 | 7 | 39815 | 164 | 31657358 |
Neutropenic infection | 17.48 | 16.00 | 14 | 39808 | 1311 | 31656211 |
Toxic erythema of chemotherapy | 17.38 | 16.00 | 6 | 39816 | 93 | 31657429 |
Cranial nerve disorder | 17.38 | 16.00 | 10 | 39812 | 542 | 31656980 |
Influenza | 17.38 | 16.00 | 18 | 39804 | 44307 | 31613215 |
Hypovolaemic shock | 17.34 | 16.00 | 30 | 39792 | 6432 | 31651090 |
Oral candidiasis | 17.23 | 16.00 | 41 | 39781 | 11036 | 31646486 |
Hyperchromasia | 17.04 | 16.00 | 3 | 39819 | 0 | 31657522 |
Carotidynia | 17.04 | 16.00 | 3 | 39819 | 0 | 31657522 |
Foetal exposure during pregnancy | 16.71 | 16.00 | 16 | 39806 | 40860 | 31616662 |
Tracheo-oesophageal fistula | 16.61 | 16.00 | 9 | 39813 | 434 | 31657088 |
Traumatic lung injury | 16.60 | 16.00 | 13 | 39809 | 1178 | 31656344 |
PO2 increased | 16.53 | 16.00 | 10 | 39812 | 595 | 31656927 |
Portosplenomesenteric venous thrombosis | 16.51 | 16.00 | 4 | 39818 | 15 | 31657507 |
Oesophageal perforation | 16.45 | 16.00 | 12 | 39810 | 978 | 31656544 |
Polyneuropathy in malignant disease | 16.40 | 16.00 | 6 | 39816 | 111 | 31657411 |
Lactic acidosis | 16.24 | 16.00 | 10 | 39812 | 31927 | 31625595 |
Retroperitoneal lymphadenopathy | 16.24 | 16.00 | 11 | 39811 | 796 | 31656726 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Malignant neoplasm progression | 1714.99 | 13.14 | 1438 | 105344 | 120301 | 70701361 |
Febrile neutropenia | 1430.90 | 13.14 | 1646 | 105136 | 202672 | 70618990 |
Neutropenia | 1254.09 | 13.14 | 1729 | 105053 | 255427 | 70566235 |
Diarrhoea | 1114.69 | 13.14 | 3122 | 103660 | 780219 | 70041443 |
Disease progression | 891.05 | 13.14 | 1137 | 105645 | 155535 | 70666127 |
Palmar-plantar erythrodysaesthesia syndrome | 756.58 | 13.14 | 505 | 106277 | 29742 | 70791920 |
Metastases to bone | 740.60 | 13.14 | 446 | 106336 | 21930 | 70799732 |
Myelosuppression | 717.39 | 13.14 | 488 | 106294 | 29657 | 70792005 |
Mucosal inflammation | 697.61 | 13.14 | 672 | 106110 | 67178 | 70754484 |
Neuropathy peripheral | 634.54 | 13.14 | 865 | 105917 | 126031 | 70695631 |
Bone marrow failure | 554.52 | 13.14 | 512 | 106270 | 48498 | 70773164 |
Metastases to liver | 513.64 | 13.14 | 375 | 106407 | 25503 | 70796159 |
Metastases to lung | 435.81 | 13.14 | 285 | 106497 | 16199 | 70805463 |
Metastases to central nervous system | 424.73 | 13.14 | 271 | 106511 | 14763 | 70806899 |
Rheumatoid arthritis | 412.82 | 13.14 | 5 | 106777 | 291800 | 70529862 |
Osteonecrosis of jaw | 396.71 | 13.14 | 393 | 106389 | 40609 | 70781053 |
Neutropenic sepsis | 396.27 | 13.14 | 316 | 106466 | 24514 | 70797148 |
Metastases to lymph nodes | 396.05 | 13.14 | 218 | 106564 | 9020 | 70812642 |
Ejection fraction decreased | 376.56 | 13.14 | 336 | 106446 | 30426 | 70791236 |
Neoplasm progression | 357.50 | 13.14 | 389 | 106393 | 44839 | 70776823 |
Agranulocytosis | 322.69 | 13.14 | 349 | 106433 | 39949 | 70781713 |
Leukopenia | 313.86 | 13.14 | 570 | 106212 | 105990 | 70715672 |
Neutrophil count decreased | 302.70 | 13.14 | 490 | 106292 | 83066 | 70738596 |
Fall | 278.14 | 13.14 | 162 | 106620 | 443934 | 70377728 |
Polyneuropathy | 274.23 | 13.14 | 240 | 106542 | 21175 | 70800487 |
Breast cancer metastatic | 269.59 | 13.14 | 176 | 106606 | 9970 | 70811692 |
Skin toxicity | 268.31 | 13.14 | 155 | 106627 | 7043 | 70814619 |
Prostatic specific antigen increased | 265.79 | 13.14 | 170 | 106612 | 9296 | 70812366 |
Stomatitis | 263.17 | 13.14 | 591 | 106191 | 127920 | 70693742 |
Interstitial lung disease | 253.01 | 13.14 | 515 | 106267 | 104170 | 70717492 |
Onycholysis | 252.64 | 13.14 | 97 | 106685 | 1706 | 70819956 |
White blood cell count decreased | 247.81 | 13.14 | 687 | 106095 | 169454 | 70652208 |
Nausea | 240.42 | 13.14 | 2138 | 104644 | 849950 | 69971712 |
Joint swelling | 236.35 | 13.14 | 47 | 106735 | 253164 | 70568498 |
Haematotoxicity | 231.01 | 13.14 | 180 | 106602 | 13494 | 70808168 |
Drug ineffective | 219.01 | 13.14 | 708 | 106074 | 939044 | 69882618 |
Decreased appetite | 210.96 | 13.14 | 963 | 105819 | 303817 | 70517845 |
Product dose omission issue | 207.95 | 13.14 | 38 | 106744 | 217430 | 70604232 |
Peripheral sensory neuropathy | 205.85 | 13.14 | 160 | 106622 | 11950 | 70809712 |
Drug abuse | 197.95 | 13.14 | 5 | 106777 | 147251 | 70674411 |
Pleural effusion | 197.85 | 13.14 | 541 | 106241 | 132323 | 70689339 |
Neutropenic colitis | 195.62 | 13.14 | 112 | 106670 | 5002 | 70816660 |
Alopecia areata | 194.01 | 13.14 | 78 | 106704 | 1558 | 70820104 |
Flushing | 191.13 | 13.14 | 398 | 106384 | 81774 | 70739888 |
Recall phenomenon | 188.82 | 13.14 | 68 | 106714 | 991 | 70820671 |
Arthropathy | 181.88 | 13.14 | 11 | 106771 | 150046 | 70671616 |
Pneumonitis | 181.30 | 13.14 | 308 | 106474 | 54289 | 70767373 |
Bone pain | 178.50 | 13.14 | 294 | 106488 | 50528 | 70771134 |
Therapeutic product effect decreased | 177.94 | 13.14 | 9 | 106773 | 143009 | 70678653 |
Madarosis | 176.82 | 13.14 | 83 | 106699 | 2440 | 70819222 |
Vomiting | 176.44 | 13.14 | 1507 | 105275 | 591604 | 70230058 |
Colitis | 173.55 | 13.14 | 330 | 106452 | 63484 | 70758178 |
Metastasis | 169.66 | 13.14 | 109 | 106673 | 6005 | 70815657 |
Contraindicated product administered | 162.74 | 13.14 | 10 | 106772 | 134602 | 70687060 |
Aortitis | 159.51 | 13.14 | 65 | 106717 | 1346 | 70820316 |
Hair texture abnormal | 158.60 | 13.14 | 83 | 106699 | 3097 | 70818565 |
Nail disorder | 158.50 | 13.14 | 129 | 106653 | 10295 | 70811367 |
Anaemia | 154.74 | 13.14 | 1088 | 105694 | 402335 | 70419327 |
Erythema | 151.86 | 13.14 | 649 | 106133 | 198914 | 70622748 |
Pyrexia | 151.42 | 13.14 | 1485 | 105297 | 605467 | 70216195 |
Overdose | 151.20 | 13.14 | 35 | 106747 | 169710 | 70651952 |
Sinusitis | 148.51 | 13.14 | 36 | 106746 | 169159 | 70652503 |
Hormone-refractory prostate cancer | 147.81 | 13.14 | 56 | 106726 | 948 | 70820714 |
Breast cancer recurrent | 145.32 | 13.14 | 75 | 106707 | 2718 | 70818944 |
Hair colour changes | 144.94 | 13.14 | 84 | 106698 | 3839 | 70817823 |
Cardiotoxicity | 141.58 | 13.14 | 124 | 106658 | 10946 | 70810716 |
Metastases to skin | 139.63 | 13.14 | 61 | 106721 | 1510 | 70820152 |
Alopecia | 136.99 | 13.14 | 627 | 106155 | 197863 | 70623799 |
Gastrointestinal toxicity | 134.30 | 13.14 | 96 | 106686 | 6309 | 70815353 |
Drug hypersensitivity | 133.68 | 13.14 | 119 | 106663 | 262340 | 70559322 |
Drug interaction | 133.45 | 13.14 | 231 | 106551 | 381210 | 70440452 |
Weight increased | 133.16 | 13.14 | 102 | 106680 | 242229 | 70579433 |
Dehydration | 130.73 | 13.14 | 679 | 106103 | 225463 | 70596199 |
Nail toxicity | 128.32 | 13.14 | 39 | 106743 | 321 | 70821341 |
Systemic lupus erythematosus | 128.07 | 13.14 | 6 | 106776 | 101896 | 70719766 |
Acute myeloid leukaemia | 128.03 | 13.14 | 193 | 106589 | 30747 | 70790915 |
Musculoskeletal stiffness | 126.65 | 13.14 | 33 | 106749 | 147727 | 70673935 |
Prostate cancer metastatic | 125.82 | 13.14 | 77 | 106705 | 3892 | 70817770 |
Somnolence | 123.31 | 13.14 | 87 | 106695 | 215519 | 70606143 |
Injection site pain | 122.73 | 13.14 | 16 | 106766 | 117603 | 70704059 |
Second primary malignancy | 122.31 | 13.14 | 123 | 106659 | 12928 | 70808734 |
Confusional state | 119.10 | 13.14 | 152 | 106630 | 284246 | 70537416 |
Capillary leak syndrome | 117.06 | 13.14 | 70 | 106712 | 3392 | 70818270 |
Paronychia | 114.90 | 13.14 | 91 | 106691 | 6983 | 70814679 |
Left ventricular dysfunction | 112.43 | 13.14 | 137 | 106645 | 17820 | 70803842 |
Dermatitis | 111.73 | 13.14 | 142 | 106640 | 19275 | 70802387 |
Lymphoedema | 111.59 | 13.14 | 109 | 106673 | 11060 | 70810602 |
Myocardial infarction | 110.98 | 13.14 | 60 | 106722 | 171585 | 70650077 |
Pemphigus | 110.89 | 13.14 | 3 | 106779 | 83033 | 70738629 |
Radiation skin injury | 108.54 | 13.14 | 49 | 106733 | 1314 | 70820348 |
Hand deformity | 105.81 | 13.14 | 6 | 106776 | 86476 | 70735186 |
Biopsy lung abnormal | 104.05 | 13.14 | 28 | 106754 | 140 | 70821522 |
Product use issue | 102.36 | 13.14 | 73 | 106709 | 179864 | 70641798 |
Condition aggravated | 101.30 | 13.14 | 319 | 106463 | 427316 | 70394346 |
Breast cancer | 99.34 | 13.14 | 180 | 106602 | 33369 | 70788293 |
Dysgeusia | 98.25 | 13.14 | 225 | 106557 | 49277 | 70772385 |
Lacrimation increased | 96.75 | 13.14 | 134 | 106648 | 19765 | 70801897 |
Abdominal discomfort | 95.92 | 13.14 | 109 | 106673 | 214549 | 70607113 |
Contusion | 94.80 | 13.14 | 37 | 106745 | 127999 | 70693663 |
Headache | 93.10 | 13.14 | 504 | 106278 | 579901 | 70241761 |
Metastases to pleura | 91.26 | 13.14 | 43 | 106739 | 1275 | 70820387 |
Plasma cell myeloma | 89.79 | 13.14 | 5 | 106777 | 73196 | 70748466 |
Therapy partial responder | 89.42 | 13.14 | 102 | 106680 | 12372 | 70809290 |
Cerebrovascular accident | 88.66 | 13.14 | 53 | 106729 | 143417 | 70678245 |
Suicide attempt | 87.47 | 13.14 | 9 | 106773 | 79501 | 70742161 |
Portal venous gas | 86.03 | 13.14 | 29 | 106753 | 343 | 70821319 |
Fatigue | 85.17 | 13.14 | 1725 | 105057 | 822594 | 69999068 |
Nail dystrophy | 84.88 | 13.14 | 37 | 106745 | 911 | 70820751 |
Metastases to meninges | 84.77 | 13.14 | 55 | 106727 | 3081 | 70818581 |
Wound | 82.80 | 13.14 | 23 | 106759 | 98709 | 70722953 |
Septic shock | 82.16 | 13.14 | 361 | 106421 | 111897 | 70709765 |
Depression | 81.55 | 13.14 | 108 | 106674 | 198866 | 70622796 |
Inappropriate schedule of product administration | 81.43 | 13.14 | 30 | 106752 | 107525 | 70714137 |
Maternal exposure during pregnancy | 81.09 | 13.14 | 36 | 106746 | 115309 | 70706353 |
Myositis | 77.97 | 13.14 | 113 | 106669 | 17376 | 70804286 |
Skin exfoliation | 77.33 | 13.14 | 203 | 106579 | 48423 | 70773239 |
Lymphangiosis carcinomatosa | 76.39 | 13.14 | 43 | 106739 | 1858 | 70819804 |
Hepatic enzyme increased | 74.24 | 13.14 | 76 | 106706 | 156914 | 70664748 |
Neutropenic infection | 74.17 | 13.14 | 43 | 106739 | 1966 | 70819696 |
Prostate cancer | 72.48 | 13.14 | 151 | 106631 | 31012 | 70790650 |
Hypokalaemia | 72.35 | 13.14 | 389 | 106393 | 130799 | 70690863 |
Hypocalcaemia | 72.08 | 13.14 | 188 | 106594 | 44671 | 70776991 |
Acute promyelocytic leukaemia | 71.49 | 13.14 | 38 | 106744 | 1464 | 70820198 |
Feeling abnormal | 70.65 | 13.14 | 66 | 106716 | 142253 | 70679409 |
Intentional product use issue | 70.62 | 13.14 | 47 | 106735 | 120095 | 70701567 |
Metastases to peritoneum | 70.48 | 13.14 | 53 | 106729 | 3766 | 70817896 |
Injury | 70.20 | 13.14 | 8 | 106774 | 65237 | 70756425 |
Pain | 70.01 | 13.14 | 608 | 106174 | 628208 | 70193454 |
Blood pressure systolic increased | 69.95 | 13.14 | 4 | 106778 | 57255 | 70764407 |
Multifocal micronodular pneumocyte hyperplasia | 69.95 | 13.14 | 18 | 106764 | 73 | 70821589 |
Bronchial polyp | 69.56 | 13.14 | 18 | 106764 | 75 | 70821587 |
Non-small cell lung cancer | 69.19 | 13.14 | 65 | 106717 | 6282 | 70815380 |
Arthritis | 68.22 | 13.14 | 31 | 106751 | 97949 | 70723713 |
Pseudocirrhosis | 66.85 | 13.14 | 28 | 106754 | 623 | 70821039 |
Mobility decreased | 66.56 | 13.14 | 36 | 106746 | 102963 | 70718699 |
Dermatitis acneiform | 65.57 | 13.14 | 74 | 106708 | 8871 | 70812791 |
Injection site erythema | 64.97 | 13.14 | 15 | 106767 | 72909 | 70748753 |
Nail discolouration | 64.78 | 13.14 | 44 | 106738 | 2662 | 70819000 |
Febrile bone marrow aplasia | 64.77 | 13.14 | 85 | 106697 | 11906 | 70809756 |
Tremor | 64.23 | 13.14 | 84 | 106698 | 155540 | 70666122 |
Loss of personal independence in daily activities | 63.74 | 13.14 | 24 | 106758 | 84886 | 70736776 |
Organising pneumonia | 63.44 | 13.14 | 77 | 106705 | 9973 | 70811689 |
Intestinal ischaemia | 62.83 | 13.14 | 84 | 106698 | 11980 | 70809682 |
Hospitalisation | 62.55 | 13.14 | 23 | 106759 | 82545 | 70739117 |
Intentional product misuse | 62.30 | 13.14 | 21 | 106761 | 79574 | 70742088 |
Dacryostenosis acquired | 62.04 | 13.14 | 24 | 106758 | 431 | 70821231 |
Arthralgia | 61.79 | 13.14 | 474 | 106308 | 502916 | 70318746 |
Metastases to spine | 61.64 | 13.14 | 49 | 106733 | 3780 | 70817882 |
Toxicity to various agents | 61.08 | 13.14 | 332 | 106450 | 381840 | 70439822 |
Osteoarthritis | 60.82 | 13.14 | 18 | 106764 | 74129 | 70747533 |
Blood cholesterol increased | 60.19 | 13.14 | 12 | 106770 | 64592 | 70757070 |
Asthma | 59.97 | 13.14 | 56 | 106726 | 120737 | 70700925 |
Hallucination | 59.90 | 13.14 | 20 | 106762 | 76240 | 70745422 |
Large intestine perforation | 58.45 | 13.14 | 85 | 106697 | 13110 | 70808552 |
Sedation | 57.91 | 13.14 | 3 | 106779 | 46728 | 70774934 |
Helicobacter infection | 57.03 | 13.14 | 8 | 106774 | 55648 | 70766014 |
Gastrointestinal necrosis | 56.92 | 13.14 | 53 | 106729 | 5065 | 70816597 |
Injection site reaction | 56.53 | 13.14 | 5 | 106777 | 49847 | 70771815 |
Pulmonary toxicity | 55.95 | 13.14 | 75 | 106707 | 10723 | 70810939 |
Anxiety | 55.93 | 13.14 | 159 | 106623 | 220171 | 70601491 |
Agitation | 55.59 | 13.14 | 36 | 106746 | 93339 | 70728323 |
International normalised ratio increased | 55.48 | 13.14 | 26 | 106756 | 80700 | 70740962 |
Psoriasis | 54.56 | 13.14 | 41 | 106741 | 98392 | 70723270 |
Aggression | 54.56 | 13.14 | 5 | 106777 | 48441 | 70773221 |
Medication error | 54.23 | 13.14 | 10 | 106772 | 56902 | 70764760 |
Neurotoxicity | 54.20 | 13.14 | 131 | 106651 | 29695 | 70791967 |
Nasal congestion | 53.76 | 13.14 | 16 | 106766 | 65656 | 70756006 |
Drug reaction with eosinophilia and systemic symptoms | 53.57 | 13.14 | 11 | 106771 | 58002 | 70763660 |
Thrombocytopenia | 53.08 | 13.14 | 572 | 106210 | 238538 | 70583124 |
Invasive ductal breast carcinoma | 53.06 | 13.14 | 54 | 106728 | 5755 | 70815907 |
Dyspnoea | 52.77 | 13.14 | 1524 | 105258 | 768536 | 70053126 |
Bradycardia | 52.73 | 13.14 | 66 | 106716 | 124549 | 70697113 |
Exposure during pregnancy | 51.97 | 13.14 | 34 | 106748 | 87683 | 70733979 |
Electrocardiogram QT prolonged | 51.37 | 13.14 | 31 | 106751 | 83486 | 70738176 |
Coma | 51.24 | 13.14 | 38 | 106744 | 91806 | 70729856 |
Drug intolerance | 50.81 | 13.14 | 172 | 106610 | 225515 | 70596147 |
Enterocolitis | 50.52 | 13.14 | 79 | 106703 | 12987 | 70808675 |
Nephrolithiasis | 50.42 | 13.14 | 6 | 106776 | 47317 | 70774345 |
Alopecia totalis | 50.29 | 13.14 | 19 | 106763 | 319 | 70821343 |
Suicidal ideation | 50.06 | 13.14 | 21 | 106761 | 69575 | 70752087 |
Acute interstitial pneumonitis | 49.80 | 13.14 | 27 | 106755 | 1083 | 70820579 |
Periarticular thenar erythema with onycholysis | 49.49 | 13.14 | 11 | 106771 | 19 | 70821643 |
HER2 positive breast cancer | 49.08 | 13.14 | 19 | 106763 | 342 | 70821320 |
Pericarditis | 48.62 | 13.14 | 34 | 106748 | 84671 | 70736991 |
Bacterial translocation | 48.25 | 13.14 | 21 | 106761 | 515 | 70821147 |
Oesophageal fistula | 48.18 | 13.14 | 19 | 106763 | 360 | 70821302 |
Injection site swelling | 47.17 | 13.14 | 5 | 106777 | 43152 | 70778510 |
Migraine | 47.03 | 13.14 | 25 | 106757 | 72213 | 70749449 |
Carotidynia | 46.85 | 13.14 | 15 | 106767 | 149 | 70821513 |
Back pain | 46.70 | 13.14 | 618 | 106164 | 270534 | 70551128 |
Glossodynia | 46.69 | 13.14 | 37 | 106745 | 86450 | 70735212 |
Vascular device infection | 46.63 | 13.14 | 59 | 106723 | 7971 | 70813691 |
Pneumothorax | 46.41 | 13.14 | 113 | 106669 | 25733 | 70795929 |
Insomnia | 46.35 | 13.14 | 170 | 106612 | 217636 | 70604026 |
Nasopharyngitis | 46.26 | 13.14 | 175 | 106607 | 222031 | 70599631 |
Irritable bowel syndrome | 46.22 | 13.14 | 10 | 106772 | 50840 | 70770822 |
Lactic acidosis | 46.16 | 13.14 | 20 | 106762 | 65004 | 70756658 |
Muscle injury | 46.08 | 13.14 | 3 | 106779 | 38491 | 70783171 |
Blood pressure fluctuation | 45.44 | 13.14 | 16 | 106766 | 58996 | 70762666 |
Metastases to chest wall | 45.35 | 13.14 | 19 | 106763 | 423 | 70821239 |
Epistaxis | 45.32 | 13.14 | 287 | 106495 | 102340 | 70719322 |
Treatment failure | 45.28 | 13.14 | 93 | 106689 | 144049 | 70677613 |
Oesophagobronchial fistula | 45.28 | 13.14 | 16 | 106766 | 220 | 70821442 |
Metastases to the mediastinum | 44.73 | 13.14 | 20 | 106762 | 524 | 70821138 |
Onychomadesis | 44.71 | 13.14 | 42 | 106740 | 4059 | 70817603 |
Tonsillar disorder | 44.65 | 13.14 | 25 | 106757 | 1069 | 70820593 |
Rhabdomyolysis | 44.53 | 13.14 | 47 | 106735 | 95713 | 70725949 |
Discomfort | 44.44 | 13.14 | 56 | 106726 | 105380 | 70716282 |
Injection site pruritus | 44.28 | 13.14 | 4 | 106778 | 39206 | 70782456 |
Neoplasm recurrence | 44.19 | 13.14 | 41 | 106741 | 3900 | 70817762 |
Breast pain | 44.14 | 13.14 | 55 | 106727 | 7316 | 70814346 |
Device related thrombosis | 43.73 | 13.14 | 33 | 106749 | 2357 | 70819305 |
Metastases to soft tissue | 43.54 | 13.14 | 18 | 106764 | 387 | 70821275 |
C-reactive protein abnormal | 43.39 | 13.14 | 4 | 106778 | 38575 | 70783087 |
Bone lesion | 43.39 | 13.14 | 47 | 106735 | 5383 | 70816279 |
Urticaria | 43.35 | 13.14 | 115 | 106667 | 162934 | 70658728 |
COVID-19 | 42.70 | 13.14 | 58 | 106724 | 105699 | 70715963 |
Cystoid macular oedema | 42.64 | 13.14 | 30 | 106752 | 1922 | 70819740 |
Erysipelas | 42.61 | 13.14 | 63 | 106719 | 9861 | 70811801 |
Onychalgia | 42.20 | 13.14 | 22 | 106760 | 814 | 70820848 |
Performance status decreased | 42.19 | 13.14 | 47 | 106735 | 5554 | 70816108 |
Hepatic lesion | 42.13 | 13.14 | 49 | 106733 | 6068 | 70815594 |
Wheezing | 41.83 | 13.14 | 48 | 106734 | 94122 | 70727540 |
Desmoplastic small round cell tumour | 41.50 | 13.14 | 15 | 106767 | 221 | 70821441 |
General physical health deterioration | 41.49 | 13.14 | 540 | 106242 | 235491 | 70586171 |
Influenza | 41.38 | 13.14 | 67 | 106715 | 113633 | 70708029 |
Hot flush | 41.36 | 13.14 | 166 | 106616 | 49418 | 70772244 |
Hypertension | 41.01 | 13.14 | 269 | 106513 | 295764 | 70525898 |
Hypoglycaemia | 40.95 | 13.14 | 49 | 106733 | 94315 | 70727347 |
Swelling | 40.87 | 13.14 | 146 | 106636 | 188393 | 70633269 |
Blood lactate dehydrogenase increased | 40.74 | 13.14 | 131 | 106651 | 34996 | 70786666 |
Computerised tomogram thorax abnormal | 40.70 | 13.14 | 30 | 106752 | 2068 | 70819594 |
PIK3CA-activated mutation | 40.58 | 13.14 | 19 | 106763 | 555 | 70821107 |
Chemotherapy | 40.42 | 13.14 | 27 | 106755 | 1589 | 70820073 |
Odynophagia | 40.01 | 13.14 | 62 | 106720 | 10113 | 70811549 |
Lumbosacral radiculoplexus neuropathy | 39.78 | 13.14 | 11 | 106771 | 62 | 70821600 |
Congestive cardiomyopathy | 39.41 | 13.14 | 64 | 106718 | 10862 | 70810800 |
Incorrect dose administered | 39.33 | 13.14 | 26 | 106756 | 66693 | 70754969 |
Basal cell carcinoma | 39.26 | 13.14 | 3 | 106779 | 33695 | 70787967 |
Product prescribing error | 38.98 | 13.14 | 6 | 106776 | 38946 | 70782716 |
Dizziness | 38.74 | 13.14 | 480 | 106302 | 463661 | 70358001 |
Swollen tongue | 38.73 | 13.14 | 5 | 106777 | 37041 | 70784621 |
Dermatomyositis | 38.67 | 13.14 | 36 | 106746 | 3439 | 70818223 |
Accidental overdose | 38.56 | 13.14 | 4 | 106778 | 35117 | 70786545 |
Enterocolitis infectious | 38.16 | 13.14 | 32 | 106750 | 2662 | 70819000 |
Mucosal infection | 38.00 | 13.14 | 17 | 106765 | 446 | 70821216 |
Road traffic accident | 37.95 | 13.14 | 4 | 106778 | 34678 | 70786984 |
Angioedema | 37.88 | 13.14 | 27 | 106755 | 66583 | 70755079 |
Drug resistance | 37.76 | 13.14 | 135 | 106647 | 38055 | 70783607 |
Lung adenocarcinoma | 37.70 | 13.14 | 52 | 106730 | 7638 | 70814024 |
Coronary artery disease | 37.59 | 13.14 | 24 | 106758 | 62712 | 70758950 |
Paraesthesia | 37.46 | 13.14 | 359 | 106423 | 145178 | 70676484 |
Constipation | 37.28 | 13.14 | 560 | 106222 | 251878 | 70569784 |
Blood glucose increased | 37.18 | 13.14 | 61 | 106721 | 102921 | 70718741 |
Adverse drug reaction | 36.93 | 13.14 | 17 | 106765 | 53327 | 70768335 |
Full blood count abnormal | 36.83 | 13.14 | 4 | 106778 | 33874 | 70787788 |
Stress | 36.78 | 13.14 | 29 | 106753 | 67937 | 70753725 |
EGFR gene mutation | 36.66 | 13.14 | 16 | 106766 | 395 | 70821267 |
Cardiac arrest | 36.51 | 13.14 | 121 | 106661 | 159713 | 70661949 |
Oral candidiasis | 36.48 | 13.14 | 101 | 106681 | 24851 | 70796811 |
Gait disturbance | 35.84 | 13.14 | 150 | 106632 | 184956 | 70636706 |
Duodenal ulcer perforation | 35.84 | 13.14 | 16 | 106766 | 51096 | 70770566 |
Systemic scleroderma | 35.75 | 13.14 | 22 | 106760 | 1123 | 70820539 |
Device related infection | 34.62 | 13.14 | 117 | 106665 | 32068 | 70789594 |
Feeling hot | 34.44 | 13.14 | 155 | 106627 | 48515 | 70773147 |
Mastectomy | 34.43 | 13.14 | 21 | 106761 | 1055 | 70820607 |
Acute respiratory distress syndrome | 34.31 | 13.14 | 138 | 106644 | 41116 | 70780546 |
Exposed bone in jaw | 34.27 | 13.14 | 34 | 106748 | 3515 | 70818147 |
Unevaluable event | 33.92 | 13.14 | 18 | 106764 | 52045 | 70769617 |
Irritability | 33.77 | 13.14 | 8 | 106774 | 38217 | 70783445 |
Adenocarcinoma | 33.44 | 13.14 | 34 | 106748 | 3619 | 70818043 |
Blood pressure increased | 33.34 | 13.14 | 158 | 106624 | 188359 | 70633303 |
Coating in mouth | 33.32 | 13.14 | 13 | 106769 | 239 | 70821423 |
Metastatic neoplasm | 33.30 | 13.14 | 38 | 106744 | 4610 | 70817052 |
Asthenopia | 33.01 | 13.14 | 27 | 106755 | 2169 | 70819493 |
Acoustic stimulation tests abnormal | 32.95 | 13.14 | 8 | 106774 | 24 | 70821638 |
Gastrointestinal haemorrhage | 32.79 | 13.14 | 102 | 106680 | 137306 | 70684356 |
Myelodysplastic syndrome | 32.68 | 13.14 | 109 | 106673 | 29676 | 70791986 |
Malignant neoplasm of pleura | 32.58 | 13.14 | 12 | 106770 | 187 | 70821475 |
Obstructive shock | 32.36 | 13.14 | 9 | 106773 | 52 | 70821610 |
Prostate cancer recurrent | 32.33 | 13.14 | 18 | 106764 | 761 | 70820901 |
Gastric perforation | 32.21 | 13.14 | 34 | 106748 | 3781 | 70817881 |
Treatment noncompliance | 32.00 | 13.14 | 15 | 106767 | 46559 | 70775103 |
Mastitis | 31.99 | 13.14 | 26 | 106756 | 2070 | 70819592 |
Pulmonary mass | 31.95 | 13.14 | 99 | 106683 | 25934 | 70795728 |
Purtscher retinopathy | 31.91 | 13.14 | 7 | 106775 | 11 | 70821651 |
Tongue coated | 31.88 | 13.14 | 21 | 106761 | 1207 | 70820455 |
Dyskinesia | 31.86 | 13.14 | 11 | 106771 | 41063 | 70780599 |
Osteoporosis | 31.73 | 13.14 | 17 | 106765 | 48890 | 70772772 |
Ejection fraction | 31.51 | 13.14 | 24 | 106758 | 1738 | 70819924 |
Drug level increased | 31.51 | 13.14 | 8 | 106774 | 36461 | 70785201 |
Vulvovaginal dryness | 30.99 | 13.14 | 24 | 106758 | 1782 | 70819880 |
Eosinophilia | 30.92 | 13.14 | 11 | 106771 | 40308 | 70781354 |
Pruritus | 30.86 | 13.14 | 352 | 106430 | 345208 | 70476454 |
Impaired healing | 30.82 | 13.14 | 40 | 106742 | 74334 | 70747328 |
Dysarthria | 30.79 | 13.14 | 29 | 106753 | 62284 | 70759378 |
Drug dependence | 30.71 | 13.14 | 9 | 106773 | 37312 | 70784350 |
Nervousness | 30.67 | 13.14 | 5 | 106777 | 31115 | 70790547 |
Type 2 diabetes mellitus | 30.59 | 13.14 | 14 | 106768 | 44066 | 70777596 |
Uterine leiomyosarcoma | 30.42 | 13.14 | 8 | 106774 | 36 | 70821626 |
Bronchitis | 30.17 | 13.14 | 84 | 106698 | 117159 | 70704503 |
Nephritis bacterial | 29.90 | 13.14 | 8 | 106774 | 39 | 70821623 |
Blood uric acid decreased | 29.89 | 13.14 | 20 | 106762 | 1180 | 70820482 |
Myalgia | 29.85 | 13.14 | 385 | 106397 | 167507 | 70654155 |
Invasive lobular breast carcinoma | 29.83 | 13.14 | 16 | 106766 | 628 | 70821034 |
Scleroderma renal crisis | 29.65 | 13.14 | 14 | 106768 | 417 | 70821245 |
Osteonecrosis | 29.61 | 13.14 | 104 | 106678 | 29056 | 70792606 |
Sarcoma | 29.59 | 13.14 | 18 | 106764 | 900 | 70820762 |
Periorbital disorder | 29.56 | 13.14 | 8 | 106774 | 41 | 70821621 |
Pericardial effusion | 29.52 | 13.14 | 133 | 106649 | 41643 | 70780019 |
Vulvovaginal candidiasis | 29.25 | 13.14 | 26 | 106756 | 2340 | 70819322 |
White blood cell count abnormal | 29.12 | 13.14 | 38 | 106744 | 5292 | 70816370 |
Barotrauma | 28.99 | 13.14 | 11 | 106771 | 187 | 70821475 |
Vascular fragility | 28.95 | 13.14 | 10 | 106772 | 128 | 70821534 |
Perforation | 28.94 | 13.14 | 20 | 106762 | 1245 | 70820417 |
Asthenia | 28.84 | 13.14 | 897 | 105885 | 456769 | 70364893 |
Hyperfibrinogenaemia | 28.61 | 13.14 | 9 | 106773 | 84 | 70821578 |
Cystitis noninfective | 28.57 | 13.14 | 20 | 106762 | 1271 | 70820391 |
Cellulitis | 28.47 | 13.14 | 250 | 106532 | 98678 | 70722984 |
Diabetes mellitus | 28.37 | 13.14 | 40 | 106742 | 71784 | 70749878 |
Tumour embolism | 28.07 | 13.14 | 10 | 106772 | 141 | 70821521 |
Ascites | 28.03 | 13.14 | 186 | 106596 | 67361 | 70754301 |
Skin reaction | 28.02 | 13.14 | 64 | 106718 | 13985 | 70807677 |
Blood creatinine decreased | 27.81 | 13.14 | 44 | 106738 | 7305 | 70814357 |
Injection site haemorrhage | 27.79 | 13.14 | 3 | 106779 | 25524 | 70796138 |
Meibomian gland dysfunction | 27.56 | 13.14 | 10 | 106772 | 149 | 70821513 |
Karnofsky scale worsened | 27.50 | 13.14 | 5 | 106777 | 0 | 70821662 |
Eubacterium infection | 27.50 | 13.14 | 5 | 106777 | 0 | 70821662 |
Gastric disorder | 27.49 | 13.14 | 8 | 106774 | 33314 | 70788348 |
Radiation necrosis | 27.42 | 13.14 | 13 | 106769 | 391 | 70821271 |
Cataract | 27.37 | 13.14 | 26 | 106756 | 55619 | 70766043 |
Hiccups | 27.34 | 13.14 | 49 | 106733 | 9003 | 70812659 |
Chest discomfort | 27.31 | 13.14 | 297 | 106485 | 124084 | 70697578 |
Cardiac dysfunction | 27.19 | 13.14 | 30 | 106752 | 3507 | 70818155 |
Laryngeal oedema | 27.17 | 13.14 | 44 | 106738 | 7451 | 70814211 |
Bursitis | 26.94 | 13.14 | 4 | 106778 | 26669 | 70794993 |
Disseminated intravascular coagulation | 26.84 | 13.14 | 111 | 106671 | 33487 | 70788175 |
Bone marrow infiltration | 26.76 | 13.14 | 14 | 106768 | 522 | 70821140 |
Balance disorder | 26.75 | 13.14 | 60 | 106722 | 90068 | 70731594 |
Cardiomyopathy | 26.73 | 13.14 | 94 | 106688 | 26279 | 70795383 |
Excessive eye blinking | 26.52 | 13.14 | 20 | 106762 | 1427 | 70820235 |
Eosinophil percentage increased | 26.49 | 13.14 | 20 | 106762 | 1430 | 70820232 |
Nicotinic acid deficiency | 26.46 | 13.14 | 10 | 106772 | 168 | 70821494 |
Colitis ulcerative | 26.46 | 13.14 | 9 | 106773 | 33914 | 70787748 |
Neck pain | 26.45 | 13.14 | 37 | 106745 | 66620 | 70755042 |
Toxic erythema of chemotherapy | 26.42 | 13.14 | 11 | 106771 | 241 | 70821421 |
Blood creatine phosphokinase increased | 26.37 | 13.14 | 32 | 106750 | 61231 | 70760431 |
Superior mesenteric artery syndrome | 26.25 | 13.14 | 10 | 106772 | 172 | 70821490 |
Pneumatosis intestinalis | 26.18 | 13.14 | 38 | 106744 | 5849 | 70815813 |
Therapy cessation | 26.15 | 13.14 | 9 | 106773 | 33667 | 70787995 |
Mucosal disorder | 26.11 | 13.14 | 28 | 106754 | 3170 | 70818492 |
Peripheral swelling | 26.09 | 13.14 | 229 | 106553 | 236334 | 70585328 |
Tumour pain | 25.82 | 13.14 | 23 | 106759 | 2075 | 70819587 |
Retinal detachment | 25.79 | 13.14 | 46 | 106736 | 8421 | 70813241 |
Limb injury | 25.69 | 13.14 | 4 | 106778 | 25748 | 70795914 |
Gait inability | 25.69 | 13.14 | 20 | 106762 | 47155 | 70774507 |
Gas gangrene | 25.69 | 13.14 | 11 | 106771 | 259 | 70821403 |
Axillary pain | 25.59 | 13.14 | 22 | 106760 | 1893 | 70819769 |
Ischaemic enteritis | 25.52 | 13.14 | 9 | 106773 | 123 | 70821539 |
Emotional distress | 25.51 | 13.14 | 12 | 106770 | 37176 | 70784486 |
Peritonitis | 25.46 | 13.14 | 92 | 106690 | 26067 | 70795595 |
Arteritis | 25.44 | 13.14 | 16 | 106766 | 849 | 70820813 |
Hydrothorax | 25.43 | 13.14 | 19 | 106763 | 1337 | 70820325 |
Prescribed overdose | 25.42 | 13.14 | 5 | 106777 | 27176 | 70794486 |
Menopausal disorder | 25.23 | 13.14 | 7 | 106775 | 40 | 70821622 |
Vessel puncture site bruise | 25.11 | 13.14 | 13 | 106769 | 474 | 70821188 |
Joint injury | 25.09 | 13.14 | 5 | 106777 | 26927 | 70794735 |
Multiple sclerosis | 25.06 | 13.14 | 4 | 106778 | 25281 | 70796381 |
Sopor | 24.90 | 13.14 | 8 | 106774 | 31259 | 70790403 |
Malignant pleural effusion | 24.78 | 13.14 | 27 | 106755 | 3112 | 70818550 |
Palmar erythema | 24.68 | 13.14 | 21 | 106761 | 1782 | 70819880 |
Metastases to ovary | 24.68 | 13.14 | 11 | 106771 | 286 | 70821376 |
Pancreatitis | 24.66 | 13.14 | 35 | 106747 | 62633 | 70759029 |
Product administration error | 24.51 | 13.14 | 7 | 106775 | 29516 | 70792146 |
Intestinal perforation | 24.51 | 13.14 | 66 | 106716 | 15978 | 70805684 |
Cytokine release syndrome | 24.47 | 13.14 | 5 | 106777 | 26462 | 70795200 |
Granulocyte count decreased | 24.45 | 13.14 | 19 | 106763 | 1418 | 70820244 |
Delirium | 24.40 | 13.14 | 47 | 106735 | 74567 | 70747095 |
Ventricular hypokinesia | 24.23 | 13.14 | 44 | 106738 | 8168 | 70813494 |
Blood alkaline phosphatase increased | 24.20 | 13.14 | 161 | 106621 | 58360 | 70763302 |
Troponin I increased | 23.56 | 13.14 | 30 | 106752 | 4078 | 70817584 |
Haemolytic uraemic syndrome | 23.43 | 13.14 | 30 | 106752 | 4100 | 70817562 |
Respiratory arrest | 23.40 | 13.14 | 28 | 106754 | 53905 | 70767757 |
Vein discolouration | 23.38 | 13.14 | 11 | 106771 | 325 | 70821337 |
Oesophageal perforation | 23.37 | 13.14 | 18 | 106764 | 1326 | 70820336 |
Mediastinitis | 23.24 | 13.14 | 15 | 106767 | 833 | 70820829 |
Retinal toxicity | 23.22 | 13.14 | 18 | 106764 | 1338 | 70820324 |
Dysphagia | 23.20 | 13.14 | 266 | 106516 | 112568 | 70709094 |
Lymphadenopathy | 23.13 | 13.14 | 139 | 106643 | 48652 | 70773010 |
Cardiac failure congestive | 23.09 | 13.14 | 115 | 106667 | 135342 | 70686320 |
Hepatic encephalopathy | 23.08 | 13.14 | 3 | 106779 | 22115 | 70799547 |
Cytomegalovirus oesophagitis | 23.05 | 13.14 | 14 | 106768 | 698 | 70820964 |
Osteoradionecrosis | 22.98 | 13.14 | 8 | 106774 | 105 | 70821557 |
Hip fracture | 22.92 | 13.14 | 7 | 106775 | 28256 | 70793406 |
Sepsis | 22.85 | 13.14 | 505 | 106277 | 244040 | 70577622 |
Necrotising retinitis | 22.78 | 13.14 | 17 | 106765 | 1194 | 70820468 |
Metastases to thorax | 22.75 | 13.14 | 9 | 106773 | 172 | 70821490 |
Renal failure | 22.67 | 13.14 | 179 | 106603 | 188891 | 70632771 |
No adverse event | 22.64 | 13.14 | 10 | 106772 | 32143 | 70789519 |
Abnormal behaviour | 22.61 | 13.14 | 12 | 106770 | 34697 | 70786965 |
Pulmonary hypertension | 22.59 | 13.14 | 22 | 106760 | 46514 | 70775148 |
Eastern Cooperative Oncology Group performance status worsened | 22.57 | 13.14 | 19 | 106763 | 1589 | 70820073 |
Carbohydrate antigen 15-3 increased | 22.51 | 13.14 | 16 | 106766 | 1042 | 70820620 |
Joint neoplasm | 22.48 | 13.14 | 7 | 106775 | 63 | 70821599 |
Panophthalmitis | 22.44 | 13.14 | 8 | 106774 | 113 | 70821549 |
Acute kidney injury | 22.33 | 13.14 | 544 | 106238 | 474080 | 70347582 |
Oesophagitis | 22.33 | 13.14 | 80 | 106702 | 22572 | 70799090 |
Sclerema | 22.30 | 13.14 | 6 | 106776 | 30 | 70821632 |
Therapy interrupted | 22.29 | 13.14 | 5 | 106777 | 24797 | 70796865 |
Liver function test abnormal | 22.27 | 13.14 | 36 | 106746 | 61110 | 70760552 |
Breast inflammation | 22.25 | 13.14 | 8 | 106774 | 116 | 70821546 |
Osteitis condensans | 22.13 | 13.14 | 6 | 106776 | 31 | 70821631 |
Hyperkalaemia | 22.13 | 13.14 | 84 | 106698 | 106507 | 70715155 |
Metastases to gastrointestinal tract | 22.06 | 13.14 | 8 | 106774 | 119 | 70821543 |
Nail bed bleeding | 22.05 | 13.14 | 12 | 106770 | 485 | 70821177 |
Gout | 22.01 | 13.14 | 4 | 106778 | 23002 | 70798660 |
Herpes zoster | 21.98 | 13.14 | 61 | 106721 | 85174 | 70736488 |
Acquired gene mutation | 21.94 | 13.14 | 21 | 106761 | 2077 | 70819585 |
Joint range of motion decreased | 21.93 | 13.14 | 6 | 106776 | 26020 | 70795642 |
Epidermolysis | 21.85 | 13.14 | 12 | 106770 | 494 | 70821168 |
Biliary sepsis | 21.65 | 13.14 | 18 | 106764 | 1480 | 70820182 |
Oral pain | 21.64 | 13.14 | 94 | 106688 | 28972 | 70792690 |
Dysaesthesia | 21.51 | 13.14 | 33 | 106749 | 5335 | 70816327 |
Depressed level of consciousness | 21.50 | 13.14 | 64 | 106718 | 87367 | 70734295 |
Poisoning | 21.49 | 13.14 | 4 | 106778 | 22618 | 70799044 |
Cytomegalovirus infection | 21.47 | 13.14 | 17 | 106765 | 39741 | 70781921 |
Colitis ischaemic | 21.44 | 13.14 | 58 | 106724 | 14079 | 70807583 |
Gastrointestinal ischaemia | 21.43 | 13.14 | 11 | 106771 | 394 | 70821268 |
Hypophagia | 21.37 | 13.14 | 121 | 106661 | 41449 | 70780213 |
Mucocutaneous disorder | 21.36 | 13.14 | 8 | 106774 | 131 | 70821531 |
Pharyngeal abscess | 21.31 | 13.14 | 13 | 106769 | 653 | 70821009 |
Pleural disorder | 21.28 | 13.14 | 14 | 106768 | 803 | 70820859 |
Post-traumatic pain | 21.28 | 13.14 | 11 | 106771 | 400 | 70821262 |
Nail infection | 21.17 | 13.14 | 21 | 106761 | 2170 | 70819492 |
Clostridium bacteraemia | 21.14 | 13.14 | 10 | 106772 | 299 | 70821363 |
Acute motor-sensory axonal neuropathy | 21.10 | 13.14 | 11 | 106771 | 407 | 70821255 |
Tumour haemorrhage | 21.06 | 13.14 | 27 | 106755 | 3695 | 70817967 |
Metabolic acidosis | 20.86 | 13.14 | 51 | 106731 | 74295 | 70747367 |
Night sweats | 20.80 | 13.14 | 21 | 106761 | 43663 | 70777999 |
Unintentional medical device removal | 20.80 | 13.14 | 38 | 106744 | 7086 | 70814576 |
Necrotising fasciitis | 20.79 | 13.14 | 33 | 106749 | 5493 | 70816169 |
Pain in extremity | 20.79 | 13.14 | 358 | 106424 | 327724 | 70493938 |
Osteolysis | 20.66 | 13.14 | 26 | 106756 | 3493 | 70818169 |
Soft tissue neoplasm | 20.60 | 13.14 | 7 | 106775 | 85 | 70821577 |
Vascular pain | 20.60 | 13.14 | 14 | 106768 | 848 | 70820814 |
Macroenzyme creatine kinase | 20.59 | 13.14 | 5 | 106777 | 15 | 70821647 |
Vulvitis | 20.59 | 13.14 | 9 | 106773 | 223 | 70821439 |
Nail ridging | 20.57 | 13.14 | 11 | 106771 | 429 | 70821233 |
Therapy responder | 20.48 | 13.14 | 11 | 106771 | 433 | 70821229 |
Hormone receptor positive breast cancer | 20.43 | 13.14 | 10 | 106772 | 323 | 70821339 |
Nasal disorder | 20.28 | 13.14 | 25 | 106757 | 3289 | 70818373 |
Hypervolaemia | 20.18 | 13.14 | 18 | 106764 | 39688 | 70781974 |
Pancreatitis viral | 20.12 | 13.14 | 5 | 106777 | 17 | 70821645 |
Hypovolaemic shock | 20.12 | 13.14 | 48 | 106734 | 10789 | 70810873 |
Status epilepticus | 20.03 | 13.14 | 6 | 106776 | 24520 | 70797142 |
Viral infection | 20.00 | 13.14 | 17 | 106765 | 38374 | 70783288 |
Skin laceration | 19.95 | 13.14 | 7 | 106775 | 25871 | 70795791 |
Laboratory test abnormal | 19.88 | 13.14 | 7 | 106775 | 25816 | 70795846 |
Muscle spasms | 19.81 | 13.14 | 143 | 106639 | 153903 | 70667759 |
Muscle spasticity | 19.77 | 13.14 | 3 | 106779 | 19686 | 70801976 |
Transdifferentiation of neoplasm | 19.76 | 13.14 | 7 | 106775 | 97 | 70821565 |
Blood triglycerides increased | 19.74 | 13.14 | 3 | 106779 | 19661 | 70802001 |
Radiation pneumonitis | 19.67 | 13.14 | 26 | 106756 | 3667 | 70817995 |
Ear infection | 19.66 | 13.14 | 9 | 106773 | 28327 | 70793335 |
Toxic optic neuropathy | 19.64 | 13.14 | 15 | 106767 | 1091 | 70820571 |
Obstruction gastric | 19.54 | 13.14 | 17 | 106765 | 1487 | 70820175 |
Heart rate decreased | 19.47 | 13.14 | 40 | 106742 | 61975 | 70759687 |
Metastases to nervous system | 19.47 | 13.14 | 6 | 106776 | 52 | 70821610 |
Salmonellosis | 19.35 | 13.14 | 17 | 106765 | 1506 | 70820156 |
Recurrent cancer | 19.28 | 13.14 | 21 | 106761 | 2420 | 70819242 |
Trigeminal nerve paresis | 19.23 | 13.14 | 4 | 106778 | 4 | 70821658 |
Infusion site plaque | 19.23 | 13.14 | 4 | 106778 | 4 | 70821658 |
Metastases to heart | 19.22 | 13.14 | 9 | 106773 | 263 | 70821399 |
Bone disorder | 19.18 | 13.14 | 64 | 106718 | 17426 | 70804236 |
Salmonella sepsis | 19.13 | 13.14 | 10 | 106772 | 372 | 70821290 |
Overflow diarrhoea | 19.13 | 13.14 | 7 | 106775 | 107 | 70821555 |
Adverse event | 19.09 | 13.14 | 28 | 106754 | 49433 | 70772229 |
Nail bed tenderness | 19.08 | 13.14 | 10 | 106772 | 374 | 70821288 |
Non-small cell lung cancer metastatic | 19.06 | 13.14 | 14 | 106768 | 960 | 70820702 |
Tympanic membrane disorder | 19.02 | 13.14 | 8 | 106774 | 180 | 70821482 |
Choroidal effusion | 18.97 | 13.14 | 12 | 106770 | 643 | 70821019 |
Pulmonary embolism | 18.97 | 13.14 | 335 | 106447 | 155532 | 70666130 |
Ovarian necrosis | 18.92 | 13.14 | 5 | 106777 | 23 | 70821639 |
Foot deformity | 18.90 | 13.14 | 4 | 106778 | 20651 | 70801011 |
Soft tissue infection | 18.88 | 13.14 | 25 | 106757 | 3532 | 70818130 |
Enteritis | 18.82 | 13.14 | 52 | 106730 | 12779 | 70808883 |
Monocyte count decreased | 18.72 | 13.14 | 23 | 106759 | 3016 | 70818646 |
Appendiceal abscess | 18.67 | 13.14 | 9 | 106773 | 281 | 70821381 |
Chronic kidney disease | 18.65 | 13.14 | 40 | 106742 | 61017 | 70760645 |
Surgery | 18.62 | 13.14 | 11 | 106771 | 29978 | 70791684 |
Hepatic function abnormal | 18.62 | 13.14 | 170 | 106612 | 67826 | 70753836 |
Disorientation | 18.49 | 13.14 | 37 | 106745 | 57886 | 70763776 |
Neuromuscular toxicity | 18.46 | 13.14 | 8 | 106774 | 194 | 70821468 |
Retinitis pigmentosa | 18.39 | 13.14 | 7 | 106775 | 120 | 70821542 |
Left ventricular dilatation | 18.38 | 13.14 | 14 | 106768 | 1014 | 70820648 |
Vaginal prolapse | 18.27 | 13.14 | 9 | 106773 | 295 | 70821367 |
Metastases to uterus | 18.19 | 13.14 | 6 | 106776 | 66 | 70821596 |
Acute myocardial infarction | 18.18 | 13.14 | 53 | 106729 | 72834 | 70748828 |
Restlessness | 18.14 | 13.14 | 22 | 106760 | 42106 | 70779556 |
Necrosis | 18.13 | 13.14 | 40 | 106742 | 8541 | 70813121 |
Metastases to adrenals | 18.10 | 13.14 | 15 | 106767 | 1227 | 70820435 |
Subclavian vein thrombosis | 18.02 | 13.14 | 20 | 106762 | 2354 | 70819308 |
Inflammatory carcinoma of the breast | 17.96 | 13.14 | 5 | 106777 | 29 | 70821633 |
Chromosomal mutation | 17.96 | 13.14 | 5 | 106777 | 29 | 70821633 |
Throat tightness | 17.93 | 13.14 | 80 | 106702 | 24942 | 70796720 |
Mental status changes | 17.93 | 13.14 | 43 | 106739 | 63058 | 70758604 |
Red blood cell sedimentation rate increased | 17.92 | 13.14 | 19 | 106763 | 38623 | 70783039 |
Renal impairment | 17.84 | 13.14 | 135 | 106647 | 143802 | 70677860 |
Abdominal pain | 17.82 | 13.14 | 656 | 106126 | 341471 | 70480191 |
Drug ineffective for unapproved indication | 17.82 | 13.14 | 19 | 106763 | 38519 | 70783143 |
Breast neoplasm | 17.73 | 13.14 | 13 | 106769 | 889 | 70820773 |
Tumour marker increased | 17.62 | 13.14 | 25 | 106757 | 3769 | 70817893 |
Hypothalamo-pituitary disorder | 17.60 | 13.14 | 14 | 106768 | 1081 | 70820581 |
Metastases to muscle | 17.59 | 13.14 | 9 | 106773 | 320 | 70821342 |
Procedural pain | 17.51 | 13.14 | 3 | 106779 | 18006 | 70803656 |
Mucosal toxicity | 17.47 | 13.14 | 11 | 106771 | 585 | 70821077 |
Aorto-oesophageal fistula | 17.43 | 13.14 | 6 | 106776 | 76 | 70821586 |
Hyperpyrexia | 17.41 | 13.14 | 30 | 106752 | 5344 | 70816318 |
Transaminases | 17.35 | 13.14 | 6 | 106776 | 77 | 70821585 |
Memory impairment | 17.35 | 13.14 | 76 | 106706 | 92565 | 70729097 |
Aspergillus infection | 17.32 | 13.14 | 3 | 106779 | 17865 | 70803797 |
Sleep disorder | 17.28 | 13.14 | 51 | 106731 | 69821 | 70751841 |
Eye swelling | 17.18 | 13.14 | 7 | 106775 | 23607 | 70798055 |
Infection | 17.16 | 13.14 | 219 | 106563 | 210566 | 70611096 |
Hypersomnia | 17.10 | 13.14 | 5 | 106777 | 20759 | 70800903 |
Merycism | 17.08 | 13.14 | 8 | 106774 | 234 | 70821428 |
Psychotic disorder | 16.97 | 13.14 | 19 | 106763 | 37682 | 70783980 |
Administration site extravasation | 16.94 | 13.14 | 14 | 106768 | 1141 | 70820521 |
Breast oedema | 16.92 | 13.14 | 5 | 106777 | 37 | 70821625 |
Hydronephrosis | 16.91 | 13.14 | 56 | 106726 | 15186 | 70806476 |
Ocular hyperaemia | 16.83 | 13.14 | 8 | 106774 | 24631 | 70797031 |
Traumatic lung injury | 16.78 | 13.14 | 19 | 106763 | 2286 | 70819376 |
Staphylococcal impetigo | 16.73 | 13.14 | 4 | 106778 | 11 | 70821651 |
Eye pain | 16.69 | 13.14 | 16 | 106766 | 34086 | 70787576 |
Osteosclerosis | 16.60 | 13.14 | 24 | 106758 | 3681 | 70817981 |
Hyperchlorhydria | 16.57 | 13.14 | 17 | 106765 | 1829 | 70819833 |
Spinal pain | 16.56 | 13.14 | 52 | 106730 | 13718 | 70807944 |
Transfusion | 16.53 | 13.14 | 4 | 106778 | 18832 | 70802830 |
Iron deficiency anaemia | 16.53 | 13.14 | 7 | 106775 | 23065 | 70798597 |
Liposarcoma metastatic | 16.50 | 13.14 | 3 | 106779 | 0 | 70821662 |
Labia enlarged | 16.50 | 13.14 | 3 | 106779 | 0 | 70821662 |
ALK gene rearrangement positive | 16.50 | 13.14 | 3 | 106779 | 0 | 70821662 |
Cannabinoid hyperemesis syndrome | 16.47 | 13.14 | 5 | 106777 | 41 | 70821621 |
Mouth ulceration | 16.37 | 13.14 | 98 | 106684 | 34251 | 70787411 |
Clostridial infection | 16.29 | 13.14 | 29 | 106753 | 5300 | 70816362 |
Haematoma | 16.27 | 13.14 | 30 | 106752 | 48388 | 70773274 |
Intervertebral disc protrusion | 16.26 | 13.14 | 6 | 106776 | 21497 | 70800165 |
Gastrointestinal perforation | 16.20 | 13.14 | 30 | 106752 | 5651 | 70816011 |
Amnesia | 16.07 | 13.14 | 34 | 106748 | 52121 | 70769541 |
Generalised oedema | 16.01 | 13.14 | 70 | 106712 | 21638 | 70800024 |
Herpes simplex sepsis | 15.96 | 13.14 | 5 | 106777 | 46 | 70821616 |
Ear pain | 15.94 | 13.14 | 11 | 106771 | 27588 | 70794074 |
Hypoalbuminaemia | 15.93 | 13.14 | 64 | 106718 | 19058 | 70802604 |
Vasculitis | 15.92 | 13.14 | 65 | 106717 | 19493 | 70802169 |
Nasal discomfort | 15.81 | 13.14 | 27 | 106755 | 4774 | 70816888 |
Leukaemia cutis | 15.78 | 13.14 | 7 | 106775 | 180 | 70821482 |
Dandy-Walker syndrome | 15.77 | 13.14 | 5 | 106777 | 48 | 70821614 |
Colony stimulating factor therapy | 15.76 | 13.14 | 10 | 106772 | 539 | 70821123 |
Therapeutic response unexpected | 15.75 | 13.14 | 4 | 106778 | 18227 | 70803435 |
Cranial nerve disorder | 15.69 | 13.14 | 13 | 106769 | 1063 | 70820599 |
Tracheo-oesophageal fistula | 15.64 | 13.14 | 10 | 106772 | 546 | 70821116 |
Glaucoma | 15.57 | 13.14 | 4 | 106778 | 18088 | 70803574 |
Haematochezia | 15.55 | 13.14 | 57 | 106725 | 73024 | 70748638 |
Miller Fisher syndrome | 15.50 | 13.14 | 7 | 106775 | 188 | 70821474 |
Atypical pneumonia | 15.49 | 13.14 | 30 | 106752 | 5845 | 70815817 |
Dysuria | 15.46 | 13.14 | 120 | 106662 | 45674 | 70775988 |
Delusion of grandeur | 15.45 | 13.14 | 12 | 106770 | 895 | 70820767 |
Osteosarcoma recurrent | 15.41 | 13.14 | 5 | 106777 | 52 | 70821610 |
Cachexia | 15.40 | 13.14 | 41 | 106741 | 9859 | 70811803 |
Portosplenomesenteric venous thrombosis | 15.39 | 13.14 | 4 | 106778 | 17 | 70821645 |
Injection site rash | 15.38 | 13.14 | 3 | 106779 | 16407 | 70805255 |
Underdose | 15.32 | 13.14 | 13 | 106769 | 29370 | 70792292 |
Hallucination, visual | 15.27 | 13.14 | 13 | 106769 | 29324 | 70792338 |
Hepatotoxicity | 15.26 | 13.14 | 116 | 106666 | 43870 | 70777792 |
Cholangitis sclerosing | 15.24 | 13.14 | 18 | 106764 | 2265 | 70819397 |
Subdural haematoma | 15.23 | 13.14 | 13 | 106769 | 29285 | 70792377 |
Extravasation | 15.21 | 13.14 | 22 | 106760 | 3375 | 70818287 |
Renal disorder | 15.18 | 13.14 | 21 | 106761 | 37988 | 70783674 |
Infusion site vesicles | 15.03 | 13.14 | 9 | 106773 | 437 | 70821225 |
Distichiasis | 15.03 | 13.14 | 4 | 106778 | 19 | 70821643 |
Scleroderma | 15.01 | 13.14 | 27 | 106755 | 4974 | 70816688 |
Upper limb fracture | 15.00 | 13.14 | 3 | 106779 | 16116 | 70805546 |
Bronchiectasis | 14.97 | 13.14 | 3 | 106779 | 16094 | 70805568 |
Tracheal stenosis | 14.94 | 13.14 | 8 | 106774 | 313 | 70821349 |
Pituitary tumour | 14.93 | 13.14 | 13 | 106769 | 1138 | 70820524 |
Cholestasis | 14.93 | 13.14 | 31 | 106751 | 47841 | 70773821 |
Bone cancer metastatic | 14.90 | 13.14 | 7 | 106775 | 206 | 70821456 |
Naevus haemorrhage | 14.78 | 13.14 | 6 | 106776 | 123 | 70821539 |
Paralysis recurrent laryngeal nerve | 14.78 | 13.14 | 6 | 106776 | 123 | 70821539 |
Pneumonia salmonella | 14.77 | 13.14 | 5 | 106777 | 60 | 70821602 |
Abortion spontaneous | 14.70 | 13.14 | 11 | 106771 | 26468 | 70795194 |
Urogenital prolapse | 14.70 | 13.14 | 4 | 106778 | 21 | 70821641 |
Ventricular tachycardia | 14.67 | 13.14 | 20 | 106762 | 36403 | 70785259 |
Haemodialysis | 14.64 | 13.14 | 4 | 106778 | 17362 | 70804300 |
Tubulointerstitial nephritis | 14.53 | 13.14 | 17 | 106765 | 33059 | 70788603 |
Bladder cancer | 14.48 | 13.14 | 4 | 106778 | 17238 | 70804424 |
Chills | 14.48 | 13.14 | 302 | 106480 | 144484 | 70677178 |
Tracheal fistula | 14.47 | 13.14 | 6 | 106776 | 130 | 70821532 |
Necrotising colitis | 14.47 | 13.14 | 12 | 106770 | 983 | 70820679 |
Hyperchromasia | 14.43 | 13.14 | 3 | 106779 | 3 | 70821659 |
Non-pitting oedema | 14.43 | 13.14 | 3 | 106779 | 3 | 70821659 |
Subretinal hyperreflective exudation | 14.43 | 13.14 | 3 | 106779 | 3 | 70821659 |
Blood pressure systolic inspiratory decreased | 14.43 | 13.14 | 3 | 106779 | 3 | 70821659 |
Sarcomatosis | 14.43 | 13.14 | 3 | 106779 | 3 | 70821659 |
Metastatic lymphoma | 14.42 | 13.14 | 7 | 106775 | 222 | 70821440 |
Femur fracture | 14.39 | 13.14 | 20 | 106762 | 36112 | 70785550 |
Acne | 14.38 | 13.14 | 10 | 106772 | 24979 | 70796683 |
Respiratory failure | 14.37 | 13.14 | 344 | 106438 | 168391 | 70653271 |
Thrombotic microangiopathy | 14.28 | 13.14 | 59 | 106723 | 17789 | 70803873 |
Vaginitis gardnerella | 14.25 | 13.14 | 4 | 106778 | 24 | 70821638 |
Abdominal rigidity | 14.25 | 13.14 | 19 | 106763 | 2702 | 70818960 |
Sinus bradycardia | 14.20 | 13.14 | 9 | 106773 | 23614 | 70798048 |
Hydrocephalus | 14.14 | 13.14 | 35 | 106747 | 8050 | 70813612 |
Folate deficiency | 14.12 | 13.14 | 20 | 106762 | 3010 | 70818652 |
Loss of consciousness | 14.12 | 13.14 | 158 | 106624 | 155558 | 70666104 |
Face oedema | 14.10 | 13.14 | 76 | 106706 | 25563 | 70796099 |
Parkinsonism | 13.95 | 13.14 | 3 | 106779 | 15322 | 70806340 |
Carotid artery aneurysm | 13.92 | 13.14 | 7 | 106775 | 240 | 70821422 |
Fear | 13.84 | 13.14 | 7 | 106775 | 20804 | 70800858 |
Metastases to bladder | 13.81 | 13.14 | 7 | 106775 | 244 | 70821418 |
Kidney infection | 13.78 | 13.14 | 6 | 106776 | 19449 | 70802213 |
Breast necrosis | 13.75 | 13.14 | 5 | 106777 | 75 | 70821587 |
Hypersensitivity pneumonitis | 13.66 | 13.14 | 21 | 106761 | 3401 | 70818261 |
Chondritis | 13.64 | 13.14 | 6 | 106776 | 151 | 70821511 |
Polyneuropathy in malignant disease | 13.53 | 13.14 | 6 | 106776 | 154 | 70821508 |
Acute hepatic failure | 13.52 | 13.14 | 13 | 106769 | 27659 | 70794003 |
Head injury | 13.50 | 13.14 | 19 | 106763 | 34122 | 70787540 |
Joint stiffness | 13.49 | 13.14 | 20 | 106762 | 35156 | 70786506 |
Neutrophil count abnormal | 13.47 | 13.14 | 20 | 106762 | 3141 | 70818521 |
Angiosarcoma | 13.45 | 13.14 | 9 | 106773 | 531 | 70821131 |
Metastases to abdominal cavity | 13.44 | 13.14 | 9 | 106773 | 532 | 70821130 |
Hernia | 13.35 | 13.14 | 3 | 106779 | 14857 | 70806805 |
Impaired work ability | 13.34 | 13.14 | 4 | 106778 | 16336 | 70805326 |
Gallbladder disorder | 13.30 | 13.14 | 5 | 106777 | 17707 | 70803955 |
Red cell distribution width increased | 13.26 | 13.14 | 48 | 106734 | 13609 | 70808053 |
Respiratory tract congestion | 13.23 | 13.14 | 5 | 106777 | 17648 | 70804014 |
HER2 positive salivary gland cancer | 13.21 | 13.14 | 3 | 106779 | 6 | 70821656 |
Pneumocystis jirovecii pneumonia | 13.19 | 13.14 | 84 | 106698 | 29998 | 70791664 |
Lymphangitis | 13.17 | 13.14 | 13 | 106769 | 1336 | 70820326 |
None
Source | Code | Description |
---|---|---|
ATC | L01CD02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Taxanes |
FDA PE | N0000175085 | Microtubule Inhibition |
FDA EPC | N0000175592 | Microtubule Inhibitor |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:38068 | antimalarials |
CHEBI has role | CHEBI:47868 | photosensitising agent |
MeSH PA | D050256 | Antimitotic Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D050257 | Tubulin Modulators |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
Carcinoma of breast | indication | 254838004 | DOID:3459 |
Malignant tumor of head and/or neck | indication | 255056009 | |
Malignant tumor of stomach | indication | 363349007 | DOID:10534 |
Malignant tumor of prostate | indication | 399068003 | DOID:10283 |
Metastatic Breast Carcinoma | indication | ||
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Malignant tumor of esophagus | off-label use | 363402007 | |
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Invasive Bladder Malignancy | off-label use | ||
Refractory Osteosarcoma | off-label use | ||
Asthenia | contraindication | 13791008 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Cardiac tamponade | contraindication | 35304003 | DOID:115 |
Body fluid retention | contraindication | 43498006 | |
Stomatitis | contraindication | 61170000 | DOID:9637 |
Diarrhea | contraindication | 62315008 | |
Acute infectious disease | contraindication | 63171007 | |
Peripheral motor neuropathy | contraindication | 95663000 | DOID:683 |
Liver function tests abnormal | contraindication | 166603001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Peripheral edema | contraindication | 271809000 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Ascites | contraindication | 389026000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Pleural Effusions | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.9 | acidic |
pKa2 | 11.64 | acidic |
pKa3 | 12.4 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 10842770 | Aug. 7, 2031 | METHOD OF ADMINISTERING DOCETAXEL TO A SUBJECT COMBINING THE DOCETAXEL PRO-EMULSION FORMULATION WITH AN AQUEOUS MEDIUM TO PRODUCE DOCETAXEL EMULSION |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
160MG/8ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
20MG/ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 8940786 | Sept. 30, 2033 | METHOD OF ADMINISTERING AN ETHANOL-FREE TAXANE LIQUID NANODISPERSION FORMULATION TO A SUBJECT COMBINING THE FORMULATION WITH AN AQUEOUS MEDIUM TO PROVIDE AN ETHANOL-FREE TAXANE DILUTED SOLUTION |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF ADVANCED GASTRIC ADENOCARCINOMA IN COMBINATION WITH CISPLATIN AND FLUOROURACIL IN PATIENTS THAT HAVE NOT RECEIVED PRIOR CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (HORMONE REFRACTORY) METASTATIC PROSTATE CANCER IN COMBINATION WITH PREDNISONE |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED METASTATIC BREAST CANCER AFTER FAILURE OF PRIOR CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER AFTER FAILURE OF PRIOR PLATINUM-BASED CHEMOTHERAPY |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK IN COMBINATION WITH CISPLATIN AND FLUOROURACIL |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH CISPLATIN FOR TREATMENT OF UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITHOUT PRIOR CHEMOTHERAPY TREATMENT |
80MG/4ML (20MG/ML) | DOCETAXEL | SHILPA | N205934 | Dec. 22, 2015 | RX | INJECTABLE | INJECTION | 9763880 | Sept. 30, 2033 | USE IN COMBINATION WITH DOXORUBICIN AND CYCLOPHOSPHAMIDE FOR ADJUVANT TREATMENT OF PATIENTS WITH OPERABLE NODE-POSITIVE BREAST CANCER |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tubulin beta | Tumour-associated antigen | INHIBITOR | ID50 | 6.70 | WOMBAT-PK | CHEMBL | |||
Multidrug resistance protein 1 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 7 | Transporter | WOMBAT-PK | |||||||
Epidermal growth factor receptor | Kinase | INHIBITOR | Kd | 9.09 | WOMBAT-PK | ||||
Substance-K receptor | GPCR | Ki | 6.28 | DRUG MATRIX | |||||
Growth hormone-releasing hormone receptor | GPCR | IC50 | 9.85 | CHEMBL | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Nucleotide-binding oligomerization domain-containing protein 2 | Cytosolic other | IC50 | 5.30 | CHEMBL |
ID | Source |
---|---|
4020968 | VUID |
N0000148441 | NUI |
D02165 | KEGG_DRUG |
148408-66-6 | SECONDARY_CAS_RN |
1299922 | RXNORM |
4020968 | VANDF |
C0246415 | UMLSCUI |
CHEBI:59809 | CHEBI |
TXL | PDB_CHEM_ID |
CHEMBL3545252 | ChEMBL_ID |
CHEMBL92 | ChEMBL_ID |
D000077143 | MESH_DESCRIPTOR_UI |
DB01248 | DRUGBANK_ID |
6809 | IUPHAR_LIGAND_ID |
15H5577CQD | UNII |
148124 | PUBCHEM_CID |
178776 | MMSL |
180476 | MMSL |
4626 | MMSL |
5984 | MMSL |
d04009 | MMSL |
005187 | NDDF |
005188 | NDDF |
108806006 | SNOMEDCT_US |
386918005 | SNOMEDCT_US |
6621 | INN_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9204 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9205 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0016 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0201 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0365 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0366 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0367 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0368 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 31 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1732 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2026 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2956 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4235 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-5068 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-7870 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1020 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1020 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1021 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1021 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1022 | INJECTION, SOLUTION, CONCENTRATE | 160 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1022 | INJECTION, SOLUTION, CONCENTRATE | 160 mg | INTRAVENOUS | NDA authorized generic | 30 sections |
DOCETAXEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-231 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 30 sections |
DOCETAXEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-231 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 30 sections |
DOCETAXEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-267 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 30 sections |
DOCETAXEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-267 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | NDA | 30 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-245 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 29 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-245 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 29 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-001 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 28 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-006 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 28 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43066-010 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 28 sections |
Docetaxel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-258 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 26 sections |