levomenthol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
934 89-78-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menthol
  • hexahydrothymol
  • menthacamphor
  • menthomenthol
  • thymomenthol
  • levomenthol
  • (-)-menthol
A monoterpene cyclohexanol produced from mint oils.
  • Molecular weight: 156.27
  • Formula: C10H20O
  • CLOGP: 3.23
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -2.45
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product adhesion issue 1620.84 17.27 317 9304 4402 63474999
Product quality issue 933.53 17.27 305 9316 35560 63443841
Drug ineffective for unapproved indication 301.88 17.27 132 9489 33931 63445470
Gastrointestinal toxicity 255.07 17.27 79 9542 7662 63471739
Pulmonary toxicity 239.52 17.27 79 9542 9376 63470025
Joint injury 175.88 17.27 87 9534 29485 63449916
Methaemoglobinaemia 172.23 17.27 45 9576 2358 63477043
Neoplasm malignant 166.23 17.27 84 9537 29777 63449624
Hepatotoxicity 160.16 17.27 88 9533 36953 63442448
C-reactive protein abnormal 112.64 17.27 76 9545 46020 63433381
Joint stiffness 111.90 17.27 73 9548 41796 63437605
Therapy non-responder 100.84 17.27 87 9534 75814 63403587
Musculoskeletal pain 86.30 17.27 87 9534 92190 63387211
Food intolerance 73.14 17.27 25 9596 3300 63476101
Drug hypersensitivity 70.29 17.27 149 9472 310538 63168863
Injection site inflammation 69.60 17.27 25 9596 3818 63475583
Musculoskeletal stiffness 56.91 17.27 101 9520 184517 63294884
No adverse event 52.00 17.27 46 9575 41359 63438042
Therapeutic product effect incomplete 51.49 17.27 78 9543 124978 63354423
Treatment failure 51.49 17.27 101 9520 198942 63280459
Urticaria thermal 45.26 17.27 11 9610 428 63478973
Drug intolerance 43.00 17.27 123 9498 308538 63170863
Infection 41.78 17.27 101 9520 229072 63250329
Off label use 41.16 17.27 206 9415 674256 62805145
Application site rash 36.94 17.27 14 9607 2484 63476917
Condition aggravated 36.86 17.27 139 9482 402078 63077323
Administration site erythema 34.70 17.27 10 9611 755 63478646
Arthropathy 34.06 17.27 95 9526 234697 63244704
Urosepsis 32.50 17.27 25 9596 18499 63460902
Nail bed tenderness 30.95 17.27 8 9613 401 63479000
Drug ineffective 30.43 17.27 265 9356 1044500 62434901
Pigmentation disorder 28.59 17.27 14 9607 4625 63474776
Application site irritation 26.57 17.27 10 9611 1740 63477661
Application site discomfort 26.34 17.27 7 9614 391 63479010
Pain in extremity 25.85 17.27 109 9512 331377 63148024
Scratch 24.02 17.27 14 9607 6551 63472850
Vitamin B12 deficiency 24.00 17.27 13 9608 5290 63474111
Hypercholesterolaemia 23.44 17.27 22 9599 21312 63458089
Autonomic neuropathy 22.73 17.27 8 9613 1151 63478250
Application site pain 21.03 17.27 11 9610 4171 63475230
Dyspepsia 20.72 17.27 47 9574 102149 63377252
Inflammation 20.32 17.27 41 9580 82232 63397169
Arthralgia 19.97 17.27 151 9470 569559 62909842
Hypoaesthesia oral 19.46 17.27 16 9605 13017 63466384
Toxic anterior segment syndrome 19.43 17.27 8 9613 1763 63477638
Toxicity to various agents 18.77 17.27 7 9614 247243 63232158
Anticipatory anxiety 18.45 17.27 7 9614 1244 63478157
Secretion discharge 18.23 17.27 15 9606 12216 63467185
Pemphigus 18.19 17.27 3 9618 183723 63295678
Cyanosis 17.72 17.27 17 9604 16918 63462483
Systemic lupus erythematosus 17.47 17.27 5 9616 208913 63270488

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product adhesion issue 638.79 22.11 109 2445 1491 34952886
Product quality issue 350.69 22.11 102 2452 16933 34937444
Methaemoglobinaemia 192.47 22.11 46 2508 3535 34950842
Drug ineffective for unapproved indication 78.24 22.11 37 2517 23678 34930699
Haemolysis 27.80 22.11 13 2541 8081 34946296
Conjunctival scar 26.01 22.11 5 2549 134 34954243
Anticholinergic syndrome 23.37 22.11 7 2547 1262 34953115

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product adhesion issue 922.99 16.34 172 8647 2532 79733037
Product quality issue 464.48 16.34 165 8654 33775 79701794
Methaemoglobinaemia 349.90 16.34 88 8731 5469 79730100
Drug ineffective for unapproved indication 143.12 16.34 82 8737 51156 79684413
Gastrointestinal toxicity 109.11 16.34 39 8780 8070 79727499
Pulmonary toxicity 94.81 16.34 40 8779 12874 79722695
Injection site inflammation 80.55 16.34 26 8793 3950 79731619
Food intolerance 77.29 16.34 25 8794 3823 79731746
Joint injury 76.52 16.34 46 8773 31289 79704280
Neoplasm malignant 65.75 16.34 42 8777 31768 79703801
Hepatotoxicity 60.23 16.34 48 8771 51304 79684265
Joint stiffness 51.84 16.34 40 8779 40790 79694779
Urticaria thermal 48.56 16.34 11 8808 434 79735135
Administration site erythema 45.01 16.34 10 8809 361 79735208
Therapy non-responder 41.34 16.34 51 8768 92254 79643315
Drug hypersensitivity 39.63 16.34 96 8723 298820 79436749
C-reactive protein abnormal 38.04 16.34 36 8783 48331 79687238
Pruritus 37.46 16.34 112 8707 394536 79341033
Urosepsis 35.93 16.34 27 8792 26468 79709101
Treatment failure 35.67 16.34 66 8753 170420 79565149
Application site rash 35.40 16.34 12 8807 2120 79733449
Nail bed tenderness 33.36 16.34 8 8811 406 79735163
Conjunctival scar 32.76 16.34 7 8812 210 79735359
Musculoskeletal pain 32.74 16.34 48 8771 102306 79633263
Toxic anterior segment syndrome 32.36 16.34 12 8807 2752 79732817
Pigmentation disorder 30.24 16.34 14 8805 5604 79729965
Musculoskeletal stiffness 28.48 16.34 61 8758 174947 79560622
Cyanosis 24.23 16.34 21 8798 25161 79710408
Vitamin B12 deficiency 24.04 16.34 13 8806 7228 79728341
Infection 22.32 16.34 68 8751 241644 79493925
Scratch 22.29 16.34 13 8806 8350 79727219
Autonomic neuropathy 21.35 16.34 8 8811 1887 79733682
Product preparation error 20.92 16.34 11 8808 5782 79729787
Anticipatory anxiety 20.87 16.34 7 8812 1197 79734372
Inflammation 20.48 16.34 37 8782 93716 79641853
Arthropathy 20.42 16.34 54 8765 177057 79558512
Angioedema 19.21 16.34 32 8787 76003 79659566
Dyspepsia 18.96 16.34 39 8780 108648 79626921
Vulvovaginal swelling 18.50 16.34 5 8814 410 79735159
Secretion discharge 17.51 16.34 14 8805 15008 79720561
Haemolysis 17.24 16.34 13 8806 12799 79722770

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:51177 anti-tussive
CHEBI has role CHEBI:53784 antispasmodics
CHEBI has role CHEBI:59683 antipruritic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis versicolor indication 56454009 DOID:9060
Diaper rash indication 91487003
Backache indication 161891005
Pityriasis simplex indication 200767005
Skin irritation indication 367466007
Local anesthesia indication 386761002
Itching of skin indication 418363000
Mouth Irritation indication
Minor Skin Wound Pain indication
Suppression of the Gag Reflex indication
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Bacterial septicemia contraindication 10001005 DOID:0040085
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Shock contraindication 27942005
Methemoglobinemia contraindication 38959009 DOID:10783
Gastrointestinal ulcer contraindication 40845000
Distinctive exudative discoid AND lichenoid chronic dermatosis of Sulzberger and Garbe contraindication 41580004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Hemochromatosis contraindication 399187006 DOID:2352
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 4.60 IUPHAR SCIENTIFIC LITERATURE
Transient receptor potential cation channel subfamily A member 1 Ion channel ACTIVATOR EC50 4.50 IUPHAR
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 5.40 IUPHAR
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 4.20 IUPHAR
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 4.20 IUPHAR

External reference:

IDSource
4018868 VUID
N0000147167 NUI
D04918 KEGG_DRUG
1430390 RXNORM
4018868 VANDF
C0771655 UMLSCUI
CHEBI:15409 CHEBI
CHEMBL470670 ChEMBL_ID
CHEMBL256087 ChEMBL_ID
DB00825 DRUGBANK_ID
6725 INN_ID
BZ1R15MTK7 UNII
16666 PUBCHEM_CID
DB14123 DRUGBANK_ID
11399 MMSL
5044 MMSL
NOCODE MMSL
001991 NDDF
005811 NDDF
387414008 SNOMEDCT_US
421208001 SNOMEDCT_US
423685001 SNOMEDCT_US
73170009 SNOMEDCT_US
D008610 MESH_DESCRIPTOR_UI
2216-51-5 SECONDARY_CAS_RN
2430 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch HUMAN OTC DRUG LABEL 2 11822-6514 PATCH 1 g TOPICAL OTC monograph not final 13 sections
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch HUMAN OTC DRUG LABEL 2 11822-6514 PATCH 1 g TOPICAL OTC monograph not final 13 sections
Dermoplast Pain Relieving HUMAN OTC DRUG LABEL 2 16864-680 SPRAY 5 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Dermoplast Sunburn and Burn Relief HUMAN OTC DRUG LABEL 2 16864-681 SPRAY 5 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Dermoplast Insect Itch and Sting Relief HUMAN OTC DRUG LABEL 2 16864-682 SPRAY 5 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
New NBF GINGIVAL Gel HUMAN OTC DRUG LABEL 2 23636-1002 GEL 0.40 g DENTAL OTC monograph not final 11 sections
AVON HeXashield Pain Relief for Muscle, Back and JointCream HUMAN OTC DRUG LABEL 3 43136-102 CREAM 100 mg TOPICAL OTC monograph not final 14 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-018 PATCH 4 mg TOPICAL OTC monograph not final 11 sections
Satogesic HUMAN OTC DRUG LABEL 3 49873-060 PATCH 4 mg TOPICAL OTC monograph not final 12 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-065 LOTION 4 g TOPICAL OTC monograph not final 11 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-068 SPRAY 4 g TOPICAL OTC monograph not final 11 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-068 SPRAY 4 g TOPICAL OTC monograph not final 11 sections
Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream HUMAN OTC DRUG LABEL 2 49873-619 CREAM 1 g TOPICAL OTC monograph not final 12 sections
Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream HUMAN OTC DRUG LABEL 2 49873-619 CREAM 1 g TOPICAL OTC monograph not final 12 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-620 LOTION 6 g TOPICAL OTC monograph not final 12 sections
Satohap Cool and Hot Pads HUMAN OTC DRUG LABEL 3 49873-621 PATCH 6 g TOPICAL OTC monograph not final 15 sections
Satohap Cool and Hot Pads HUMAN OTC DRUG LABEL 3 49873-621 PATCH 6 g TOPICAL OTC monograph not final 15 sections
Tact CoolJelly HUMAN OTC DRUG LABEL 2 49873-704 GEL 1 g TOPICAL OTC monograph not final 10 sections
TACT HUMAN OTC DRUG LABEL 2 49873-705 CREAM 1 g TOPICAL OTC monograph not final 10 sections
RICHENNAPHARMGROWMAX Hair care Tonic HUMAN OTC DRUG LABEL 2 50629-1005 LIQUID 0.40 mL TOPICAL unapproved drug other 4 sections
ELIZABETH HEALTH STYLE CHESTRUB VAPORIZING ACTION HUMAN OTC DRUG LABEL 3 52920-135 OINTMENT 2.60 g TOPICAL OTC monograph not final 7 sections
Pain ReliefPatches Patches HUMAN OTC DRUG LABEL 3 53043-001 PATCH 4 mL TOPICAL OTC monograph not final 10 sections
Mini Pain Relief HUMAN OTC DRUG LABEL 3 53043-003 PATCH 2.70 mg TOPICAL OTC monograph not final 10 sections
GINSENGGO HUMAN OTC DRUG LABEL 3 55264-005 PATCH 1.40 mg TOPICAL OTC monograph not final 12 sections
Sinsin Mulpas HUMAN OTC DRUG LABEL 3 55264-007 LIQUID 4.20 mg TOPICAL OTC monograph not final 10 sections
Sinsin Mulpas HUMAN OTC DRUG LABEL 3 55264-007 LIQUID 4.20 mg TOPICAL OTC monograph not final 10 sections
SINSINPAP COOL HUMAN OTC DRUG LABEL 5 55264-012 PATCH 49.40 mg TOPICAL OTC monograph not final 12 sections
SINSINPAP COOL HUMAN OTC DRUG LABEL 5 55264-012 PATCH 49.40 mg TOPICAL OTC monograph not final 12 sections
Arex Sinsin Pas HUMAN OTC DRUG LABEL 5 55264-020 PATCH 45.45 mg TOPICAL OTC monograph not final 14 sections
Arex Sinsin Pas HUMAN OTC DRUG LABEL 5 55264-020 PATCH 45.45 mg TOPICAL OTC monograph not final 14 sections