levomenthol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
934 89-78-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menthol
  • hexahydrothymol
  • menthacamphor
  • menthomenthol
  • thymomenthol
  • levomenthol
  • (-)-menthol
A monoterpene cyclohexanol produced from mint oils.
  • Molecular weight: 156.27
  • Formula: C10H20O
  • CLOGP: 3.23
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -2.45
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 5.365 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 3.882 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 3.499 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 163.305 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 1.200 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 2.410 % High 1
herg hERG pIC50 4.856 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 63.680 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 136.458 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 1.640 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IKBKB,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 40
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.184 High 1
mh-clint Mouse hepatocyte intrinsic clearance 175.792 High 1
mppb Mouse plasma protein binding (% unbound) 1.010 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.594 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 1.480 % High 1
rh-clint Rat hepatocyte intrinsic clearance 216.272 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 0.690 % High 1
rppb Rat plasma protein binding (% unbound) 3.040 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 0.490 uM High 1

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 762.96 8.86 253 120187 3247 90504760
Macular degeneration 491.57 8.86 406 120034 37564 90470443
Maternal exposure during delivery 267.06 8.86 121 120319 3725 90504282
Methaemoglobinaemia 237.37 8.86 113 120327 3902 90504105
Chronic sinusitis 226.90 8.86 214 120226 23588 90484419
Paraesthesia oral 197.83 8.86 227 120213 31432 90476575
Nicotine dependence 197.69 8.86 68 120372 982 90507025
Toxic anterior segment syndrome 195.87 8.86 83 120357 2167 90505840
Anaphylactic reaction 185.29 8.86 379 120061 87145 90420862
Vaginal flatulence 182.28 8.86 144 120296 12494 90495513
Hand deformity 180.46 8.86 84 120356 296278 90211729
Systemic lupus erythematosus 180.08 8.86 131 120309 361765 90146242
Cardiac arrest 175.17 8.86 413 120027 104522 90403485
Contraindicated product administered 173.96 8.86 105 120335 320034 90187973
Pemphigus 172.37 8.86 111 120329 326753 90181254
Anaphylactic shock 171.64 8.86 211 120229 31406 90476601
Glossodynia 168.69 8.86 110 120330 321669 90186338
Toxicity to various agents 168.34 8.86 793 119647 287053 90220954
Female genital tract fistula 163.37 8.86 157 120283 17711 90490296
Procedural pain 162.63 8.86 211 120229 33149 90474858
Synovitis 160.64 8.86 122 120318 329630 90178377
Proctitis 158.62 8.86 144 120296 15115 90492892
Radiculopathy 153.18 8.86 154 120286 18351 90489656
Drug withdrawal syndrome neonatal 151.71 8.86 70 120370 2249 90505758
Kounis syndrome 151.37 8.86 72 120368 2481 90505526
Vaginal discharge 146.67 8.86 154 120286 19310 90488697
Premature delivery 143.82 8.86 215 120225 38547 90469460
Anti-cyclic citrullinated peptide antibody positive 140.86 8.86 69 120371 236364 90271643
Hypotension 131.39 8.86 810 119630 324587 90183420
Sedation complication 131.15 8.86 136 120304 16808 90491199
Hepatic enzyme increased 128.43 8.86 175 120265 360561 90147446
Abdominal discomfort 126.70 8.86 279 120161 477049 90030958
Alopecia 124.45 8.86 298 120142 494773 90013234
Joint swelling 122.56 8.86 308 120132 502992 90005015
Pericarditis 113.34 8.86 115 120325 270036 90237971
Duodenal ulcer perforation 110.12 8.86 80 120360 221208 90286799
Therapeutic product effect decreased 107.78 8.86 126 120314 277445 90230562
Oral candidiasis 103.13 8.86 176 120264 35279 90472728
Gastrointestinal toxicity 101.67 8.86 91 120349 9376 90498631
Creatinine renal clearance decreased 100.76 8.86 125 120315 18774 90489233
Infusion site pain 96.44 8.86 125 120315 19613 90488394
Anaesthetic complication 95.05 8.86 52 120388 2413 90505594
Upper respiratory tract infection 92.00 8.86 376 120064 127942 90380065
Ill-defined disorder 91.78 8.86 67 120373 184824 90323183
Infusion site swelling 90.58 8.86 94 120346 11626 90496381
Sinusitis 88.28 8.86 767 119673 342321 90165686
Swelling 88.19 8.86 275 120165 418783 90089224
General physical health deterioration 88.17 8.86 215 120225 354900 90153107
Wound 87.15 8.86 169 120271 302811 90205196
Generalised tonic-clonic seizure 87.04 8.86 162 120278 34741 90473266
Overdose 86.66 8.86 427 120013 157282 90350725
Constipation 85.72 8.86 652 119788 279743 90228264
Depressed level of consciousness 83.27 8.86 249 120191 72535 90435472
Stress cardiomyopathy 82.15 8.86 95 120345 13260 90494747
Insurance issue 81.31 8.86 86 120354 10872 90497135
Folliculitis 81.21 8.86 91 120349 204262 90303745
Pulmonary toxicity 79.42 8.86 87 120353 11444 90496563
Infusion site erythema 77.06 8.86 93 120347 13577 90494430
Helicobacter infection 76.76 8.86 114 120326 226736 90281271
Infusion site extravasation 74.77 8.86 80 120360 10248 90497759
Blister 74.40 8.86 141 120299 254857 90253150
Drug intolerance 74.29 8.86 324 120116 447267 90060740
Lower respiratory tract infection 73.66 8.86 138 120302 250521 90257486
Arthropathy 73.10 8.86 246 120194 365996 90142011
Infusion site pruritus 72.59 8.86 65 120375 6700 90501307
Abdominal pain upper 71.60 8.86 216 120224 332458 90175549
Pulseless electrical activity 69.68 8.86 72 120368 8860 90499147
Blood calcium decreased 68.99 8.86 135 120305 30047 90477960
Colitis 67.82 8.86 226 120214 69716 90438291
Lip dry 65.55 8.86 26 120414 100929 90407078
Product adhesion issue 64.47 8.86 54 120386 5088 90502919
Rheumatoid factor positive 62.31 8.86 82 120358 171568 90336439
Rheumatoid arthritis 62.29 8.86 259 120181 362355 90145652
Hypersensitivity 60.16 8.86 356 120084 454321 90053686
Psoriatic arthropathy 60.04 8.86 134 120306 228201 90279806
Facet joint syndrome 59.65 8.86 28 120412 98361 90409646
Procedural hypotension 59.62 8.86 33 120407 1567 90506440
Impaired healing 58.72 8.86 141 120299 234058 90273949
Infusion site haemorrhage 58.08 8.86 52 120388 5359 90502648
Bradycardia 57.96 8.86 243 120197 83604 90424403
Creatinine renal clearance increased 57.50 8.86 42 120398 3239 90504768
Peripheral venous disease 57.19 8.86 20 120420 83901 90424106
Foetal exposure during pregnancy 55.91 8.86 154 120286 42821 90465186
Muscle injury 55.73 8.86 93 120347 176561 90331446
Sedation 55.28 8.86 165 120275 48006 90460001
Infusion site bruising 54.99 8.86 46 120394 4326 90503681
Tachycardia 54.08 8.86 377 120063 157296 90350711
Illness 53.91 8.86 234 120206 81735 90426272
Anaesthetic complication neurological 53.63 8.86 24 120416 717 90507290
Gastrointestinal disorder 53.55 8.86 169 120271 256518 90251489
Erythema 53.03 8.86 501 119939 228745 90279262
Obesity 52.64 8.86 38 120402 105469 90402538
Discomfort 52.19 8.86 188 120252 274147 90233860
Neoplasm malignant 51.84 8.86 129 120311 33751 90474256
Corneal oedema 51.78 8.86 32 120408 1869 90506138
Product use issue 51.02 8.86 245 120195 329674 90178333
Sulphaemoglobinaemia 50.89 8.86 21 120419 512 90507495
Myocardial stunning 50.23 8.86 18 120422 295 90507712
Joint stiffness 49.96 8.86 221 120219 77821 90430186
Drug dependence 49.52 8.86 116 120324 29211 90478796
Pulse absent 49.39 8.86 50 120390 6005 90502002
Renal function test abnormal 49.08 8.86 54 120386 7137 90500870
Rhesus incompatibility 49.04 8.86 14 120426 104 90507903
Unresponsive to stimuli 48.99 8.86 136 120304 37985 90470022
Systemic toxicity 48.58 8.86 17 120423 259 90507748
Stomatitis 48.53 8.86 194 120246 274504 90233503
Incorrect drug administration rate 47.94 8.86 46 120394 5177 90502830
Seizure 47.76 8.86 357 120083 152272 90355735
Bronchitis 46.90 8.86 356 120084 152571 90355436
Jaundice neonatal 46.55 8.86 24 120416 986 90507021
Arthralgia 46.31 8.86 742 119698 777780 89730227
Rectal haemorrhage 46.11 8.86 225 120215 82519 90425488
Mental status changes 45.67 8.86 147 120293 44532 90463475
Joint injury 45.45 8.86 120 120320 32544 90475463
Premature baby 45.45 8.86 102 120338 24975 90483032
Emotional distress 45.35 8.86 129 120311 36533 90471474
Sleep disorder due to general medical condition, insomnia type 45.16 8.86 63 120377 128631 90379376
Therapeutic product effect incomplete 44.96 8.86 424 120016 193472 90314535
Liver injury 44.91 8.86 100 120340 170467 90337540
Dermatitis contact 44.25 8.86 71 120369 13524 90494483
Rheumatic fever 43.48 8.86 86 120354 153035 90354972
Ear infection 42.72 8.86 195 120245 69580 90438427
Truncus arteriosus persistent 42.40 8.86 17 120423 384 90507623
Infusion site urticaria 42.03 8.86 27 120413 1688 90506319
Apnoea 41.96 8.86 57 120383 9357 90498650
Bursitis 41.81 8.86 69 120371 131585 90376422
Inflammation 41.29 8.86 112 120328 178480 90329527
Urinary tract infection 41.21 8.86 602 119838 305030 90202977
Extradural abscess 40.81 8.86 24 120416 1280 90506727
Asthenia 40.54 8.86 484 119956 533267 89974740
Administration site erythema 40.18 8.86 21 120419 888 90507119
Lung disorder 40.17 8.86 87 120353 149796 90358211
Frequent bowel movements 40.12 8.86 166 120274 56769 90451238
Colitis ulcerative 38.83 8.86 171 120269 60095 90447912
Hepatitis 38.65 8.86 23 120417 70716 90437291
Orthostatic hypotension 38.64 8.86 133 120307 41694 90466313
Myelosuppression 37.86 8.86 12 120428 53579 90454428
Ventricular tachycardia 37.72 8.86 94 120346 24614 90483393
Fear 37.56 8.86 74 120366 16548 90491459
Extradural haematoma 37.44 8.86 27 120413 2041 90505966
Drug abuse 37.01 8.86 211 120229 82136 90425871
Seasonal allergy 36.74 8.86 89 120351 22894 90485113
Lagophthalmos 36.45 8.86 16 120424 456 90507551
Haematochezia 36.11 8.86 188 120252 70725 90437282
Broncholithiasis 35.91 8.86 14 120426 293 90507714
Low birth weight baby 35.81 8.86 53 120387 9414 90498593
Congenital cardiovascular anomaly 35.63 8.86 16 120424 482 90507525
Rash 35.50 8.86 797 119643 795303 89712704
Anterior chamber cell 35.41 8.86 18 120422 718 90507289
Peripheral nerve injury 35.34 8.86 18 120422 721 90507286
Diarrhoea 34.94 8.86 966 119474 938224 89569783
Administration site pain 34.91 8.86 21 120419 1168 90506839
Confusional state 33.77 8.86 339 120101 385866 90122141
COVID-19 33.71 8.86 358 120082 168485 90339522
Ventricular fibrillation 33.54 8.86 64 120376 13980 90494027
Food intolerance 33.26 8.86 33 120407 3869 90504138
Liver disorder 32.82 8.86 70 120370 121199 90386808
Night sweats 32.67 8.86 77 120363 128689 90379318
Lymph node calcification 32.67 8.86 14 120426 376 90507631
Spinal epidural haemorrhage 32.66 8.86 13 120427 288 90507719
Injection site inflammation 32.56 8.86 35 120405 4506 90503501
Nail disorder 32.56 8.86 19 120421 59048 90448959
Sputum purulent 32.43 8.86 21 120419 1331 90506676
X-ray abnormal 32.40 8.86 10 120430 45414 90462593
Cognitive disorder 31.95 8.86 179 120261 69228 90438779
Hypopyon 31.74 8.86 18 120422 896 90507111
Embolia cutis medicamentosa 31.73 8.86 16 120424 627 90507380
Infusion site mass 31.69 8.86 25 120415 2164 90505843
Accidental overdose 31.64 8.86 96 120344 28177 90479830
Weight decreased 31.19 8.86 692 119748 379218 90128789
Oligohydramnios 31.19 8.86 43 120397 7158 90500849
Staphylococcal infection 30.87 8.86 137 120303 48302 90459705
Treatment failure 30.80 8.86 257 120183 303671 90204336
Pneumocephalus 30.52 8.86 12 120428 257 90507750
Thrombocytopenia 30.52 8.86 158 120282 208567 90299440
Inappropriate schedule of product administration 30.44 8.86 319 120121 149614 90358393
Irritable bowel syndrome 30.35 8.86 157 120283 207291 90300716
Bursitis infective 30.32 8.86 21 120419 1489 90506518
Spinal epidural haematoma 30.24 8.86 20 120420 1314 90506693
Type I hypersensitivity 29.75 8.86 32 120408 4123 90503884
Tobacco abuse 29.65 8.86 16 120424 722 90507285
Seronegative arthritis 29.57 8.86 71 120369 18163 90489844
Sleep disorder 29.47 8.86 149 120291 197881 90310126
Joint dislocation 29.10 8.86 127 120313 44455 90463552
Blepharospasm 28.94 8.86 19 120421 55426 90452581
Condition aggravated 28.31 8.86 590 119850 594955 89913052
Endophthalmitis 28.27 8.86 33 120407 4652 90503355
Bundle branch block left 28.19 8.86 43 120397 7842 90500165
Secondary immunodeficiency 28.06 8.86 23 120417 2103 90505904
Status epilepticus 27.97 8.86 71 120369 18803 90489204
Necrosis ischaemic 27.74 8.86 17 120423 978 90507029
Electrocardiogram QRS complex prolonged 27.59 8.86 41 120399 7307 90500700
Disease progression 27.39 8.86 111 120329 156504 90351503
Infusion site discharge 27.33 8.86 24 120416 2411 90505596
Anhedonia 27.18 8.86 52 120388 11379 90496628
Headache 26.83 8.86 1402 119038 861344 89646663
Neutropenia 26.66 8.86 182 120258 224722 90283285
Vascular malformation 26.63 8.86 15 120425 737 90507270
Anxiety 26.61 8.86 568 119872 309204 90198803
Multiple drug therapy 26.17 8.86 39 120401 6970 90501037
Meningitis chemical 26.14 8.86 11 120429 282 90507725
Cardiac septal defect 26.03 8.86 15 120425 770 90507237
Tobacco interaction 25.92 8.86 8 120432 80 90507927
Blood cholesterol increased 25.83 8.86 166 120274 207846 90300161
Bronchospasm 25.74 8.86 73 120367 20636 90487371
Paraplegia 25.71 8.86 27 120413 3385 90504622
Paranasal cyst 25.59 8.86 15 120425 795 90507212
Hypoaesthesia oral 25.57 8.86 61 120379 15539 90492468
Urticaria thermal 25.54 8.86 13 120427 520 90507487
Purtscher retinopathy 25.49 8.86 9 120431 141 90507866
Epidural haemorrhage 25.41 8.86 11 120429 303 90507704
Parophthalmia 25.29 8.86 12 120428 411 90507596
Anal skin tags 25.27 8.86 14 120426 666 90507341
Stress 25.23 8.86 190 120250 81205 90426802
Poor feeding infant 25.20 8.86 13 120427 535 90507472
Cauda equina syndrome 25.10 8.86 18 120422 1349 90506658
Onychomadesis 25.06 8.86 15 120425 45983 90462024
Fear of eating 25.05 8.86 12 120428 420 90507587
Dyspepsia 25.00 8.86 386 120054 197774 90310233
Infusion site rash 24.96 8.86 23 120417 2460 90505547
Vitritis 24.59 8.86 19 120421 1595 90506412
Substance abuse 24.50 8.86 33 120407 5373 90502634
Sinus tachycardia 24.05 8.86 88 120352 28425 90479582
Dry mouth 23.82 8.86 145 120295 183914 90324093
Drug ineffective for unapproved indication 23.81 8.86 161 120279 66483 90441524
Respiratory tract infection 23.73 8.86 147 120293 58931 90449076
Corneal epithelium defect 23.60 8.86 12 120428 479 90507528
Infusion site nodule 23.50 8.86 19 120421 1704 90506303
Platelet aggregation inhibition 23.46 8.86 9 120431 180 90507827
Aqueous fibrin 23.29 8.86 8 120432 115 90507892
Ophthalmoplegia 23.25 8.86 19 120421 1730 90506277
Fatigue 22.87 8.86 1278 119162 1152745 89355262
Stridor 22.86 8.86 30 120410 4763 90503244
Respiratory depression 22.47 8.86 58 120382 15517 90492490
Renal injury 22.42 8.86 45 120395 10198 90497809
Spinal cord compression 22.29 8.86 30 120410 4881 90503126
Trigeminal palsy 22.25 8.86 7 120433 75 90507932
Product dose omission issue 21.96 8.86 525 119915 291162 90216845
Medical device site cellulitis 21.90 8.86 9 120431 217 90507790
Hypoxia 21.88 8.86 168 120272 72231 90435776
Congenital tricuspid valve incompetence 21.84 8.86 8 120432 140 90507867
Septic arthritis staphylococcal 21.77 8.86 12 120428 565 90507442
Administration site swelling 21.44 8.86 17 120423 1482 90506525
Multiple allergies 21.43 8.86 56 120384 15090 90492917
Balance disorder 21.35 8.86 210 120230 96870 90411137
Drug interaction 20.94 8.86 498 119942 275955 90232052
Loss of proprioception 20.77 8.86 11 120429 478 90507529
Epidural analgesia 20.72 8.86 8 120432 163 90507844
Product distribution issue 20.55 8.86 25 120415 3680 90504327
Procedure aborted 20.49 8.86 8 120432 168 90507839
Neurotoxicity 20.48 8.86 69 120371 21398 90486609
Body tinea 19.87 8.86 19 120421 2129 90505878
Peripheral swelling 19.68 8.86 409 120031 412697 90095310
Lichen nitidus 19.52 8.86 7 120433 115 90507892
Application site erythema 19.47 8.86 29 120411 5179 90502828
Kidney infection 19.40 8.86 77 120363 25839 90482168
Underdose 19.39 8.86 26 120414 53991 90454016
Medical device site abscess 19.09 8.86 8 120432 203 90507804
Congenital pulmonary hypertension 19.03 8.86 7 120433 124 90507883
Cyanosis 18.97 8.86 63 120377 19392 90488615
Retinal vasculitis 18.94 8.86 16 120424 1525 90506482
Haemorrhoids 18.93 8.86 78 120362 26624 90481383
Vitamin D increased 18.63 8.86 13 120427 933 90507074
Nerve root injury 18.53 8.86 6 120434 71 90507936
Foetal heart rate abnormal 18.43 8.86 13 120427 949 90507058
Otitis media 18.21 8.86 30 120410 5840 90502167
Punctate keratitis 18.20 8.86 12 120428 784 90507223
Heart disease congenital 18.00 8.86 16 120424 1633 90506374
Abortion induced 17.91 8.86 45 120395 11843 90496164
Drug hypersensitivity 17.90 8.86 474 119966 463135 90044872
Obstructive airways disorder 17.89 8.86 75 120365 25794 90482213
Mastoiditis 17.83 8.86 16 120424 1654 90506353
Neuromuscular block prolonged 17.82 8.86 11 120429 641 90507366
Localised infection 17.79 8.86 90 120350 33472 90474535
Product preparation error 17.77 8.86 41 120399 10220 90497787
Atonic urinary bladder 17.76 8.86 7 120433 151 90507856
Liver function test abnormal 17.72 8.86 25 120415 50820 90457187
Respiratory distress 17.63 8.86 100 120340 38846 90469161
Spinal anaesthesia 17.61 8.86 6 120434 84 90507923
Upper airway obstruction 17.61 8.86 13 120427 1019 90506988
Gait inability 17.61 8.86 118 120322 146338 90361669
Meningitis aseptic 17.59 8.86 32 120408 6741 90501266
Coeliac disease 17.56 8.86 20 120420 44590 90463417
Unevaluable event 17.54 8.86 129 120311 54719 90453288
Swollen joint count increased 17.50 8.86 82 120358 111124 90396883
Acute kidney injury 17.46 8.86 310 120130 320077 90187930
Foetal exposure during delivery 17.43 8.86 9 120431 371 90507636
Incorrect route of product administration 17.31 8.86 121 120319 50505 90457502
Sexual abuse 17.31 8.86 8 120432 258 90507749
Breast cancer stage II 17.27 8.86 13 120427 35321 90472686
Tobacco poisoning 17.17 8.86 6 120434 91 90507916
Tenderness 17.12 8.86 76 120364 26792 90481215
Circulatory collapse 17.07 8.86 72 120368 24832 90483175
Hyperthermia malignant 17.04 8.86 14 120426 1284 90506723
Weight increased 17.01 8.86 424 120016 417503 90090504
Maternal exposure during breast feeding 16.94 8.86 30 120410 6190 90501817
Reversible cerebral vasoconstriction syndrome 16.90 8.86 24 120416 4106 90503901
Exposure via breast milk 16.88 8.86 18 120422 2297 90505710
Pneumocystis jirovecii pneumonia 16.84 8.86 4 120436 21612 90486395
Infusion site discomfort 16.68 8.86 16 120424 1800 90506207
Skin infection 16.67 8.86 57 120383 17807 90490200
Airway peak pressure increased 16.62 8.86 9 120431 409 90507598
Drug resistance 16.49 8.86 10 120430 30439 90477568
Immunodeficiency 16.36 8.86 20 120420 43214 90464793
Pneumonia streptococcal 16.24 8.86 17 120423 2124 90505883
Gastrooesophageal reflux disease 16.23 8.86 142 120298 166195 90341812
Ventricular hypokinesia 16.17 8.86 27 120413 5314 90502693
Nystagmus 16.12 8.86 32 120408 7195 90500812
Maternal alcohol use 16.08 8.86 4 120436 16 90507991
Fibromyalgia 16.02 8.86 186 120254 206083 90301924
Monoplegia 16.00 8.86 22 120418 3652 90504355
Infusion site warmth 15.99 8.86 17 120423 2161 90505846
Epilepsy 15.84 8.86 56 120384 82150 90425857
Cellulitis 15.65 8.86 188 120252 91149 90416858
Back pain 15.59 8.86 541 119899 316634 90191373
Intentional product use issue 15.55 8.86 199 120241 216693 90291314
Chronic obstructive pulmonary disease 15.41 8.86 158 120282 73671 90434336
Therapy partial responder 15.32 8.86 64 120376 21979 90486028
Laboratory test abnormal 15.17 8.86 20 120420 41834 90466173
Eclampsia 15.15 8.86 9 120431 489 90507518
Inadequate analgesia 15.10 8.86 20 120420 3204 90504803
Nerve block 14.99 8.86 11 120429 854 90507153
Mydriasis 14.98 8.86 49 120391 14963 90493044
Chemical burn 14.87 8.86 9 120431 506 90507501
Infusion site discolouration 14.83 8.86 12 120428 1077 90506930
Heliotrope rash 14.80 8.86 7 120433 238 90507769
Atelectasis 14.78 8.86 68 120372 24341 90483666
Cardiogenic shock 14.69 8.86 68 120372 24400 90483607
Nail bed tenderness 14.65 8.86 8 120432 370 90507637
Caesarean section 14.56 8.86 56 120384 18521 90489486
Vascular stenosis 14.54 8.86 9 120431 527 90507480
Eye infarction 14.48 8.86 5 120435 73 90507934
Vocal cord dysfunction 14.45 8.86 11 120429 903 90507104
Onychomycosis 14.45 8.86 17 120423 37359 90470648
Type 2 diabetes mellitus 14.37 8.86 187 120253 203057 90304950
Loss of consciousness 14.33 8.86 264 120176 139974 90368033
Spinal synovial cyst 14.30 8.86 5 120435 76 90507931
Back injury 14.27 8.86 25 120415 46597 90461410
Transferrin decreased 14.26 8.86 8 120432 390 90507617
Muscle spasms 13.94 8.86 243 120197 251640 90256367
Malignant neoplasm progression 13.92 8.86 84 120356 106786 90401221
Taste disorder 13.92 8.86 39 120401 61507 90446500
Application site burn 13.83 8.86 11 120429 963 90507044
Apgar score low 13.79 8.86 12 120428 1191 90506816
Cardiac death 13.78 8.86 9 120431 579 90507428
Heparin-induced thrombocytopenia 13.67 8.86 25 120415 5287 90502720
Left ventricle outflow tract obstruction 13.65 8.86 8 120432 424 90507583
Lethargy 13.60 8.86 136 120304 63003 90445004
Anaphylactoid shock 13.55 8.86 8 120432 430 90507577
C-reactive protein 13.54 8.86 13 120427 31354 90476653
Pulmonary oedema 13.51 8.86 134 120306 61946 90446061
Eyelid ptosis 13.47 8.86 34 120406 8972 90499035
Pancytopenia 13.42 8.86 99 120341 120164 90387843
Adverse event 13.42 8.86 96 120344 117322 90390685
Device expulsion 13.38 8.86 21 120419 40865 90467142
Delayed recovery from anaesthesia 13.29 8.86 11 120429 1019 90506988
Bone marrow failure 13.17 8.86 14 120426 32207 90475800
Polyarthritis 13.16 8.86 4 120436 18346 90489661
Product label confusion 13.10 8.86 7 120433 22843 90485164
Iron binding capacity total decreased 13.09 8.86 8 120432 458 90507549
Hepatotoxicity 13.09 8.86 105 120335 45737 90462270
Procedural complication 13.08 8.86 26 120414 5852 90502155
Poikiloderma 13.07 8.86 7 120433 311 90507696
Eyelid contusion 12.90 8.86 5 120435 103 90507904
Allergy to immunoglobulin therapy 12.88 8.86 6 120434 197 90507810
Bronchial wall thickening 12.84 8.86 15 120425 2116 90505891
Suicide attempt 12.83 8.86 54 120386 75345 90432662
Drug screen positive 12.75 8.86 20 120420 3737 90504270
Leukopenia 12.68 8.86 80 120360 100630 90407377
Finger deformity 12.68 8.86 15 120425 32882 90475125
Apnoeic attack 12.58 8.86 7 120433 336 90507671
Anal sphincter atony 12.58 8.86 7 120433 336 90507671
Blood creatinine increased 12.53 8.86 81 120359 101305 90406702
Pancreatitis 12.51 8.86 49 120391 69777 90438230
Orbital infection 12.51 8.86 5 120435 112 90507895
Hepatocellular injury 12.50 8.86 12 120428 28946 90479061
Xanthogranuloma 12.49 8.86 3 120437 10 90507997
Vasoplegia syndrome 12.48 8.86 17 120423 2797 90505210
Scratch 12.48 8.86 35 120405 9831 90498176
Intercepted medication error 12.46 8.86 10 120430 887 90507120
C-reactive protein increased 12.42 8.86 168 120272 181221 90326786
Inhibitory drug interaction 12.39 8.86 18 120422 3145 90504862
Anorgasmia 12.36 8.86 9 120431 691 90507316
Neonatal toxicity 12.30 8.86 4 120436 48 90507959
Axillary nerve injury 12.23 8.86 4 120436 49 90507958
Brain stem syndrome 12.09 8.86 9 120431 715 90507292
Arthritis bacterial 12.08 8.86 29 120411 7416 90500591
Retinal artery occlusion 12.07 8.86 15 120425 2256 90505751
Pancreatitis acute 12.00 8.86 15 120425 32100 90475907
Vaginal abscess 11.98 8.86 8 120432 534 90507473
Economic problem 11.88 8.86 18 120422 3263 90504744
Symphysiolysis 11.87 8.86 3 120437 13 90507994
Incorrect product administration duration 11.82 8.86 54 120386 19268 90488739
Electrocardiogram ST segment depression 11.79 8.86 18 120422 3285 90504722
Conjunctival oedema 11.79 8.86 10 120430 959 90507048
Anterior chamber fibrin 11.78 8.86 5 120435 131 90507876
Respiratory failure 11.77 8.86 222 120218 118196 90389811
Axonal neuropathy 11.77 8.86 11 120429 1198 90506809
Breast cancer stage III 11.74 8.86 65 120375 84382 90423625
Fibula agenesis 11.68 8.86 4 120436 57 90507950
Productive cough 11.66 8.86 155 120285 76908 90431099
Tryptase increased 11.65 8.86 8 120432 559 90507448
Spina bifida occulta 11.61 8.86 4 120436 58 90507949
Vasospasm 11.61 8.86 10 120430 979 90507028
Administration site extravasation 11.61 8.86 11 120429 1219 90506788
Nausea 11.58 8.86 1663 118777 1108653 89399354
Aspartate aminotransferase decreased 11.57 8.86 10 120430 983 90507024
Exposure during pregnancy 11.55 8.86 406 120034 238004 90270003
Vascular resistance systemic decreased 11.54 8.86 5 120435 138 90507869
Post procedural complication 11.49 8.86 53 120387 18989 90489018
Spinal stroke 11.43 8.86 4 120436 61 90507946
Infusion site streaking 11.40 8.86 8 120432 579 90507428
Body dysmorphic disorder 11.40 8.86 7 120433 404 90507603
Pneumonia mycoplasmal 11.32 8.86 10 120430 1012 90506995
Spinal fusion surgery 11.29 8.86 39 120401 12244 90495763
Soft tissue necrosis 11.29 8.86 9 120431 791 90507216
Proctalgia 11.28 8.86 30 120410 8168 90499839
Ventricular extrasystoles 11.26 8.86 41 120399 13209 90494798
Infusion site scar 11.17 8.86 8 120432 598 90507409
Implant site bruising 11.17 8.86 7 120433 419 90507588
Cardiac failure congestive 11.13 8.86 81 120359 98613 90409394
End-tidal CO2 decreased 11.08 8.86 4 120436 67 90507940
Arthritis fungal 11.08 8.86 4 120436 67 90507940
Porphyria acute 11.07 8.86 5 120435 17970 90490037
Nasal mucosal disorder 11.07 8.86 13 120427 1844 90506163
Respiratory arrest 11.03 8.86 79 120361 33232 90474775
Drug tolerance decreased 11.00 8.86 16 120424 32114 90475893
Adverse reaction 10.97 8.86 14 120426 29698 90478309
Foetal death 10.95 8.86 7 120433 20716 90487291
Ventricular septal defect 10.95 8.86 23 120417 5384 90502623
Product contamination microbial 10.94 8.86 6 120434 280 90507727
Victim of spousal abuse 10.92 8.86 3 120437 19 90507988
Injection site atrophy 10.86 8.86 9 120431 835 90507172
Beta haemolytic streptococcal infection 10.85 8.86 15 120425 2504 90505503
Viral infection 10.83 8.86 93 120347 41321 90466686
Disease recurrence 10.81 8.86 21 120419 37632 90470375
Intraocular pressure fluctuation 10.77 8.86 4 120436 73 90507934
Gastric mucosa erythema 10.76 8.86 7 120433 447 90507560
Procedural anxiety 10.75 8.86 9 120431 847 90507160
Tremor 10.71 8.86 273 120167 152900 90355107
Trigemino-cardiac reflex 10.67 8.86 4 120436 75 90507932
Gastroenteritis viral 10.64 8.86 73 120367 30282 90477725
Diplopia 10.63 8.86 70 120370 28644 90479363
Sinusitis bacterial 10.60 8.86 13 120427 1930 90506077
Pubic pain 10.55 8.86 5 120435 171 90507836
Drug reaction with eosinophilia and systemic symptoms 10.50 8.86 26 120414 42732 90465275
Poor quality product administered 10.49 8.86 19 120421 3989 90504018
Electrocardiogram ST segment elevation 10.46 8.86 19 120421 3997 90504010
Cancer pain 10.43 8.86 19 120421 4006 90504001
Peripheral vascular disorder 10.38 8.86 25 120415 6406 90501601
Diabetes mellitus inadequate control 10.31 8.86 6 120434 18678 90489329
Osteonecrosis of jaw 10.22 8.86 23 120417 39080 90468927
Paralysis 10.17 8.86 36 120404 11442 90496565
Fear-related avoidance of activities 10.16 8.86 5 120435 186 90507821
Poor venous access 10.10 8.86 52 120388 19475 90488532
Akinesia 10.10 8.86 12 120428 1724 90506283
Product availability issue 10.10 8.86 27 120413 7377 90500630
Infusion site oedema 10.09 8.86 10 120430 1171 90506836
Accelerated idioventricular rhythm 10.07 8.86 4 120436 88 90507919
Premature separation of placenta 10.07 8.86 14 120426 2348 90505659
Product contamination 10.07 8.86 10 120430 1174 90506833
Application site alopecia 10.00 8.86 3 120437 27 90507980
Interstitial lung disease 9.98 8.86 60 120380 76345 90431662
Drug eruption 9.95 8.86 20 120420 35387 90472620
Blood pressure fluctuation 9.90 8.86 36 120404 52377 90455630
Muscle spasticity 9.88 8.86 20 120420 35302 90472705
Hepatic enzyme decreased 9.88 8.86 9 120431 949 90507058
Visual acuity reduced 9.87 8.86 59 120381 23351 90484656
Fat embolism 9.86 8.86 6 120434 341 90507666
Phrenic nerve paralysis 9.81 8.86 6 120434 344 90507663
Skin discolouration 9.81 8.86 96 120344 44219 90463788
Agitation 9.76 8.86 134 120306 66964 90441043
Chills 9.75 8.86 237 120203 131744 90376263
Nephrolithiasis 9.75 8.86 104 120336 48981 90459026
Orbital oedema 9.75 8.86 6 120434 348 90507659
Nail bed inflammation 9.74 8.86 12 120428 1789 90506218
Retinal cyst 9.71 8.86 4 120436 97 90507910
Blood methaemoglobin present 9.71 8.86 4 120436 97 90507910
Application site pruritus 9.71 8.86 19 120421 4228 90503779
Vision blurred 9.70 8.86 203 120237 110090 90397917
Application site vesicles 9.68 8.86 11 120429 1506 90506501
Myelitis transverse 9.66 8.86 11 120429 1509 90506498
Electrocardiogram PR shortened 9.65 8.86 7 120433 534 90507473
Repetitive strain injury 9.55 8.86 5 120435 212 90507795
Mean arterial pressure decreased 9.53 8.86 5 120435 213 90507794
Thunderclap headache 9.53 8.86 6 120434 362 90507645
Infection susceptibility increased 9.51 8.86 18 120422 3908 90504099
Wrong product administered 9.51 8.86 27 120413 7638 90500369
Haemangioma congenital 9.48 8.86 7 120433 549 90507458
Sympathectomy 9.46 8.86 3 120437 33 90507974
Coccygectomy 9.46 8.86 3 120437 33 90507974
Retinal detachment 9.43 8.86 25 120415 6797 90501210
Haemorrhagic vasculitis 9.42 8.86 4 120436 105 90507902
Carcinogenicity 9.38 8.86 3 120437 34 90507973
Cytomegalovirus infection 9.35 8.86 13 120427 26589 90481418
Cholestasis of pregnancy 9.33 8.86 11 120429 1566 90506441
White blood cell count decreased 9.31 8.86 161 120279 166948 90341059
Implant site swelling 9.30 8.86 7 120433 565 90507442
False positive investigation result 9.27 8.86 8 120432 785 90507222
Streptococcal infection 9.26 8.86 26 120414 7307 90500700
Gastric disorder 9.26 8.86 19 120421 33365 90474642
Quadriparesis 9.25 8.86 14 120426 2535 90505472
Allergy to metals 9.25 8.86 9 120431 1031 90506976
Vulvovaginal swelling 9.24 8.86 8 120432 788 90507219
Angioedema 9.21 8.86 129 120311 64747 90443260
Bacterial infection 9.20 8.86 58 120382 23386 90484621
Red blood cell sedimentation rate decreased 9.19 8.86 9 120431 1039 90506968
Quadriplegia 9.18 8.86 13 120427 2218 90505789
Atrioventricular block second degree 9.09 8.86 19 120421 4433 90503574
Cerebral congestion 9.08 8.86 4 120436 115 90507892
Cytopenia 9.08 8.86 6 120434 17443 90490564
Metapneumovirus infection 9.07 8.86 10 120430 1325 90506682
Anaphylactoid reaction 9.04 8.86 19 120421 4449 90503558
Hordeolum 9.02 8.86 20 120420 4858 90503149
Tricuspid valve prolapse 9.01 8.86 3 120437 39 90507968
Incision site rash 9.01 8.86 3 120437 39 90507968
Genital ulceration 9.01 8.86 9 120431 1064 90506943
White blood cell disorder 9.00 8.86 15 120425 2949 90505058
Cholestasis 8.97 8.86 22 120418 36277 90471730
Infusion site irritation 8.96 8.86 10 120430 1343 90506664
Panniculitis 8.94 8.86 4 120436 14454 90493553
Ureteritis 8.92 8.86 4 120436 120 90507887
Antipsychotic drug level decreased 8.90 8.86 6 120434 407 90507600

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 475.38 10.22 163 61298 2137 42557737
Toxicity to various agents 287.69 10.22 852 60609 228284 42331590
Methaemoglobinaemia 286.40 10.22 148 61313 5626 42554248
Anaphylactic reaction 187.87 10.22 268 61193 42475 42517399
Anaphylactic shock 185.50 10.22 198 61263 23319 42536555
Drug withdrawal syndrome neonatal 172.69 10.22 97 61364 4364 42555510
Overdose 171.22 10.22 431 61030 104833 42455041
Inspiratory capacity decreased 152.77 10.22 78 61383 2889 42556985
Cardiac arrest 130.58 10.22 400 61061 108920 42450954
Anaesthetic complication 110.60 10.22 50 61411 1407 42558467
Nicotine dependence 108.59 10.22 40 61421 653 42559221
Accidental overdose 100.77 10.22 161 61300 28169 42531705
Toxic anterior segment syndrome 96.23 10.22 45 61416 1371 42558503
Hypotension 80.74 10.22 641 60820 256990 42302884
Ventricular tachycardia 74.39 10.22 146 61315 30014 42529860
Generalised tonic-clonic seizure 71.59 10.22 133 61328 26246 42533628
Injury 71.50 10.22 121 61340 22195 42537679
Unresponsive to stimuli 70.28 10.22 146 61315 31257 42528617
Drug dependence 69.54 10.22 139 61322 28955 42530919
Fear 67.18 10.22 81 61380 10884 42548990
Tachycardia 63.95 10.22 302 61159 100785 42459089
Emotional distress 62.15 10.22 95 61366 15998 42543876
Ventricular fibrillation 58.22 10.22 132 61329 29991 42529883
Maternal exposure during breast feeding 57.99 10.22 33 61428 1522 42558352
Bradycardia 56.72 10.22 259 61202 85225 42474649
Anhedonia 56.16 10.22 62 61399 7578 42552296
Diarrhoea 53.72 10.22 417 61044 460432 42099442
Interstitial lung disease 53.57 10.22 23 61438 78439 42481435
Renal injury 52.45 10.22 76 61385 12204 42547670
Foetal exposure during pregnancy 50.80 10.22 167 61294 47144 42512730
Endophthalmitis 49.22 10.22 45 61416 4388 42555486
Electrocardiogram ST segment elevation 48.58 10.22 51 61410 5888 42553986
Product adhesion issue 46.97 10.22 30 61431 1709 42558165
Sinus tachycardia 46.18 10.22 96 61365 20557 42539317
Drug ineffective 45.93 10.22 1210 60251 628987 41930887
Incorrect product administration duration 45.45 10.22 49 61412 5831 42554043
Disease progression 43.08 10.22 89 61372 143567 42416307
Exposure via breast milk 41.74 10.22 32 61429 2445 42557429
Hypoxia 40.88 10.22 204 61257 69582 42490292
Brain oedema 40.21 10.22 79 61382 16248 42543626
Bronchospasm 40.13 10.22 69 61392 12816 42547058
Intentional product misuse 39.90 10.22 186 61275 61714 42498160
Anal inflammation 38.01 10.22 29 61432 2200 42557674
Infusion site extravasation 37.75 10.22 43 61418 5438 42554436
Sinusitis 37.28 10.22 151 61310 47141 42512733
Infusion site pain 36.61 10.22 42 61419 5353 42554521
Adulterated product 36.16 10.22 19 61442 747 42559127
Drug abuse 35.66 10.22 266 61195 104505 42455369
Drug screen positive 34.73 10.22 36 61425 4095 42555779
Jaundice neonatal 34.22 10.22 27 61434 2152 42557722
Hyperthermia malignant 33.53 10.22 29 61432 2629 42557245
Breech presentation 33.27 10.22 12 61449 184 42559690
Insurance issue 33.05 10.22 35 61426 4081 42555793
Spinal cord infarction 32.81 10.22 17 61444 649 42559225
SARS-CoV-2 test negative 32.28 10.22 24 61437 1751 42558123
Trigemino-cardiac reflex 32.24 10.22 14 61447 357 42559517
Drug abuser 31.92 10.22 32 61429 3499 42556375
Ophthalmoplegia 31.87 10.22 26 61435 2174 42557700
Incorrect route of product administration 31.86 10.22 92 61369 24213 42535661
Poor feeding infant 31.75 10.22 18 61443 824 42559050
Stress 31.60 10.22 137 61324 44075 42515799
Rheumatoid arthritis 31.34 10.22 11 61450 42429 42517445
Tobacco poisoning 30.76 10.22 8 61453 36 42559838
Accident 30.36 10.22 42 61419 6461 42553413
Mydriasis 30.03 10.22 49 61412 8721 42551153
Chemical burn 29.63 10.22 13 61448 340 42559534
Substance abuse 29.47 10.22 49 61412 8856 42551018
Infusion site erythema 29.44 10.22 31 61430 3591 42556283
Drug ineffective for unapproved indication 29.22 10.22 138 61323 46025 42513849
Proctalgia 28.99 10.22 43 61418 7050 42552824
Weight decreased 28.63 10.22 179 61282 207769 42352105
Loss of consciousness 28.38 10.22 229 61232 92125 42467749
Tremor neonatal 28.30 10.22 14 61447 484 42559390
Tobacco abuse 28.20 10.22 15 61446 605 42559269
Premature baby 27.84 10.22 85 61376 23068 42536806
Acute kidney injury 27.52 10.22 369 61092 366968 42192906
Ear infection 26.87 10.22 58 61403 12746 42547128
Cauda equina syndrome 26.70 10.22 17 61444 963 42558911
Alcohol abuse 26.60 10.22 31 61430 4018 42555856
Oculocardiac reflex 26.38 10.22 9 61452 116 42559758
Electrocardiogram QRS complex prolonged 26.28 10.22 37 61424 5786 42554088
Respiratory arrest 25.87 10.22 95 61366 28329 42531545
Anaesthetic complication neurological 25.79 10.22 15 61446 721 42559153
Cardiac failure congestive 25.67 10.22 53 61408 85549 42474325
Haematochezia 25.44 10.22 28 61433 58408 42501466
General physical health deterioration 25.30 10.22 122 61339 151124 42408750
Mental status changes 25.28 10.22 124 61337 41991 42517883
Decreased appetite 25.18 10.22 169 61292 192968 42366906
Prostate cancer 24.76 10.22 17 61444 44626 42515248
Foetal distress syndrome 23.75 10.22 17 61444 1169 42558705
Diabetes insipidus 23.68 10.22 28 61433 3685 42556189
Cardiogenic shock 23.62 10.22 108 61353 35532 42524342
Fatigue 23.54 10.22 465 60996 435176 42124698
Status epilepticus 23.42 10.22 62 61399 15516 42544358
Tracheitis 23.39 10.22 16 61445 1023 42558851
Injection related reaction 22.77 10.22 13 61448 603 42559271
Negative pressure pulmonary oedema 22.60 10.22 13 61448 612 42559262
Respiratory tract infection bacterial 22.42 10.22 20 61441 1889 42557985
Unevaluable event 22.06 10.22 103 61358 34185 42525689
Haemodynamic instability 22.04 10.22 53 61408 12504 42547370
Hypoxic-ischaemic encephalopathy 21.93 10.22 32 61429 5170 42554704
Leukopenia 21.81 10.22 47 61414 74699 42485175
Brain stem syndrome 21.63 10.22 13 61448 664 42559210
Choroiditis 21.51 10.22 17 61444 1358 42558516
Neurotoxicity 21.48 10.22 79 61382 23572 42536302
Cytomegalovirus infection 21.21 10.22 10 61451 32296 42527578
Oropharyngeal discomfort 21.20 10.22 28 61433 4121 42555753
Application site erythema 20.92 10.22 22 61439 2544 42557330
Kounis syndrome 20.82 10.22 25 61436 3343 42556531
Exposure to chemical pollution 19.94 10.22 4 61457 3 42559871
Rhesus incompatibility 19.93 10.22 6 61455 50 42559824
Respiratory tract infection 19.91 10.22 83 61378 26239 42533635
Myoclonus 19.91 10.22 62 61399 17003 42542871
Circulatory collapse 19.85 10.22 77 61384 23559 42536315
Seizure 19.79 10.22 263 61198 120298 42439576
Miosis 19.69 10.22 53 61408 13393 42546481
Pulmonary oedema 19.69 10.22 138 61323 53134 42506740
Infusion site swelling 19.64 10.22 24 61437 3268 42556606
Accidental death 19.25 10.22 23 61438 3060 42556814
Asthenia 19.24 10.22 287 61174 280506 42279368
Anxiety 19.19 10.22 258 61203 118302 42441572
Pain 19.10 10.22 475 60986 244373 42315501
Postictal state 19.02 10.22 14 61447 1006 42558868
Blood phosphorus increased 18.98 10.22 50 61411 12475 42547399
Respiratory depression 18.83 10.22 65 61396 18803 42541071
Vasoplegia syndrome 18.57 10.22 21 61440 2634 42557240
Venolymphatic malformation 18.17 10.22 5 61456 29 42559845
Laryngeal dysplasia 18.14 10.22 4 61457 7 42559867
Retinal artery occlusion 18.08 10.22 19 61442 2196 42557678
Intracranial hypotension 17.98 10.22 10 61451 441 42559433
Lagophthalmos 17.98 10.22 7 61454 134 42559740
Laryngospasm 17.94 10.22 18 61443 1970 42557904
Postoperative delirium 17.84 10.22 11 61450 589 42559285
Clostridium test positive 17.83 10.22 30 61431 5475 42554399
Body temperature abnormal 17.82 10.22 13 61448 921 42558953
Post procedural complication 17.81 10.22 49 61412 12541 42547333
Hepatotoxicity 17.78 10.22 7 61454 25160 42534714
Corneal oedema 17.75 10.22 16 61445 1532 42558342
Myalgia 17.55 10.22 75 61386 96005 42463869
Melaena 17.50 10.22 18 61443 38728 42521146
Aqueous fibrin 17.47 10.22 6 61455 79 42559795
Low birth weight baby 17.45 10.22 42 61419 9913 42549961
Neuromuscular blockade 17.41 10.22 9 61452 342 42559532
Anticholinergic syndrome 17.39 10.22 16 61445 1573 42558301
Embolia cutis medicamentosa 17.34 10.22 9 61452 345 42559529
Behaviour disorder 17.21 10.22 34 61427 7020 42552854
Pancreatitis acute 17.04 10.22 14 61447 33550 42526324
Myocardial infarction 16.91 10.22 107 61354 123902 42435972
Abdominal discomfort 16.86 10.22 54 61407 75201 42484673
Type I hypersensitivity 16.65 10.22 18 61443 2148 42557726
Wrong product procured 16.63 10.22 3 61458 0 42559874
Febrile neutropenia 16.53 10.22 367 61094 185336 42374538
Agranulocytosis 16.52 10.22 12 61449 30600 42529274
Weight increased 16.41 10.22 90 61371 107893 42451981
Reperfusion arrhythmia 16.34 10.22 6 61455 97 42559777
Drug withdrawal syndrome 16.34 10.22 68 61393 21481 42538393
Coronary artery disease 16.32 10.22 33 61428 53687 42506187
Visual acuity reduced 16.26 10.22 59 61402 17491 42542383
Pneumocystis jirovecii pneumonia 16.22 10.22 8 61453 25173 42534701
Spinal meningeal cyst 16.01 10.22 6 61455 103 42559771
Apnoea 15.97 10.22 35 61426 7768 42552106
Seizure like phenomena 15.97 10.22 13 61448 1084 42558790
Macular ischaemia 15.96 10.22 7 61454 183 42559691
Ventricular extrasystoles 15.95 10.22 49 61412 13341 42546533
Respiratory tract infection viral 15.90 10.22 22 61439 3384 42556490
Myelosuppression 15.90 10.22 21 61440 40440 42519434
Hyperphosphataemia 15.87 10.22 48 61413 12956 42546918
Thrombocytopenia 15.75 10.22 187 61274 190092 42369782
Accidental exposure to product by child 15.65 10.22 15 61446 1552 42558322
Malignant neoplasm progression 15.58 10.22 92 61369 108308 42451566
Neuropathy peripheral 15.42 10.22 85 61376 101768 42458106
Pancytopenia 15.34 10.22 103 61358 117640 42442234
Erythema 15.31 10.22 231 61230 108562 42451312
Polyneuropathy 15.29 10.22 4 61457 18657 42541217
Tryptase increased 15.05 10.22 8 61453 322 42559552
Delirium 14.93 10.22 128 61333 52391 42507483
Hyperaesthesia 14.89 10.22 29 61432 5923 42553951
Appendicolith 14.89 10.22 48 61413 13408 42546466
Administration site pain 14.88 10.22 9 61452 465 42559409
Restlessness 14.71 10.22 82 61379 29167 42530707
Drug therapy 14.66 10.22 30 61431 6350 42553524
Iron deficiency 14.62 10.22 42 61419 11019 42548855
Thyrotoxic crisis 14.55 10.22 11 61450 823 42559051
Substance dependence 14.45 10.22 10 61451 652 42559222
Arthritis 14.42 10.22 24 61437 42041 42517833
Drug use disorder 14.41 10.22 40 61421 10293 42549581
Catecholamine crisis 14.28 10.22 5 61456 70 42559804
Withdrawal catatonia 14.26 10.22 7 61454 238 42559636
Hyperbilirubinaemia neonatal 14.21 10.22 11 61450 853 42559021
Analgesic therapy 14.20 10.22 30 61431 6494 42553380
Liver disorder 14.17 10.22 22 61439 39622 42520252
Loss of personal independence in daily activities 13.97 10.22 32 61429 49784 42510090
Blood pressure fluctuation 13.94 10.22 11 61450 26897 42532977
Application site pain 13.93 10.22 17 61444 2312 42557562
Open globe injury 13.78 10.22 5 61456 78 42559796
Injection site ulcer 13.77 10.22 8 61453 384 42559490
Asthma 13.75 10.22 45 61416 62269 42497605
Respiratory acidosis 13.65 10.22 29 61432 6302 42553572
Death 13.55 10.22 549 60912 470636 42089238
Acne infantile 13.55 10.22 5 61456 82 42559792
Anal sphincter atony 13.50 10.22 6 61455 162 42559712
Enterobacter pneumonia 13.49 10.22 9 61452 552 42559322
International normalised ratio increased 13.46 10.22 31 61430 48137 42511737
Dehydration 13.45 10.22 135 61326 141632 42418242
Alcohol interaction 13.45 10.22 16 61445 2119 42557755
Vitreous disorder 13.43 10.22 6 61455 164 42559710
Meningitis neonatal 13.34 10.22 3 61458 6 42559868
Infusion site bruising 13.27 10.22 11 61450 941 42558933
Myasthenia gravis 13.09 10.22 52 61409 16085 42543789
Sleep disorder therapy 13.08 10.22 30 61431 6864 42553010
Neuralgia 12.96 10.22 72 61389 25575 42534299
Ventricular asystole 12.92 10.22 7 61454 293 42559581
Tubulointerstitial nephritis 12.78 10.22 16 61445 31532 42528342
Paraesthesia oral 12.73 10.22 25 61436 5138 42554736
Platelet count decreased 12.72 10.22 133 61328 138448 42421426
Torsade de pointes 12.71 10.22 34 61427 8560 42551314
Arthralgia 12.63 10.22 214 61247 205024 42354850
Suicide attempt 12.62 10.22 30 61431 46070 42513804
Dermatitis contact 12.58 10.22 23 61438 4480 42555394
Therapeutic product effect incomplete 12.57 10.22 56 61405 70883 42488991
Electrocardiogram T wave amplitude increased 12.55 10.22 5 61456 102 42559772
Phaeochromocytoma crisis 12.46 10.22 5 61456 104 42559770
Renal hypoplasia 12.37 10.22 5 61456 106 42559768
Hypersensitivity 12.33 10.22 159 61302 72211 42487663
Off label use 12.33 10.22 775 60686 637560 41922314
Product availability issue 12.31 10.22 20 61441 3547 42556327
Anaemia 12.28 10.22 309 61152 279969 42279905
Cardio-respiratory arrest 12.27 10.22 134 61327 58502 42501372
Encephalomalacia 12.23 10.22 11 61450 1050 42558824
Disease recurrence 12.08 10.22 15 61446 29663 42530211
Oesophageal injury 11.98 10.22 6 61455 213 42559661
Nystagmus 11.96 10.22 25 61436 5371 42554503
Myokymia 11.91 10.22 5 61456 117 42559757
Respiratory paralysis 11.91 10.22 5 61456 117 42559757
Transient ischaemic attack 11.80 10.22 19 61442 33720 42526154
Wrong product administered 11.71 10.22 27 61434 6199 42553675
Depressed level of consciousness 11.65 10.22 113 61348 47857 42512017
Synovitis 11.55 10.22 4 61457 15563 42544311
Neutropenia neonatal 11.53 10.22 10 61451 910 42558964
Hypopyon 11.48 10.22 8 61453 527 42559347
Pulse absent 11.42 10.22 27 61434 6300 42553574
Hypophosphataemia 11.39 10.22 60 61401 20885 42538989
Pulmonary fibrosis 11.37 10.22 13 61448 26668 42533206
Delayed recovery from anaesthesia 11.32 10.22 11 61450 1158 42558716
Drug resistance 11.32 10.22 20 61441 34228 42525646
Agitation neonatal 11.21 10.22 12 61449 1416 42558458
Priapism 11.20 10.22 27 61434 6380 42553494
Underdose 11.19 10.22 5 61456 16661 42543213
Mean arterial pressure increased 11.17 10.22 4 61457 60 42559814
Sleep deficit 11.17 10.22 10 61451 949 42558925
Hepatic failure 11.07 10.22 24 61437 38076 42521798
Vitreous floaters 11.06 10.22 21 61440 4209 42555665
Bacteroides infection 11.03 10.22 16 61445 2571 42557303
Pulmonary valve stenosis congenital 10.98 10.22 5 61456 143 42559731
White blood cell count decreased 10.94 10.22 104 61357 110292 42449582
Hepatic enzyme increased 10.86 10.22 32 61429 45752 42514122
Agitation 10.83 10.22 141 61320 64173 42495701
Ventricular tachyarrhythmia 10.81 10.22 7 61454 408 42559466
Procedural hypotension 10.78 10.22 10 61451 993 42558881
Haemorrhoids 10.73 10.22 51 61410 17046 42542828
Joint swelling 10.71 10.22 56 61405 67966 42491908
Pulmonary congestion 10.67 10.22 48 61413 15682 42544192
Vitamin D abnormal 10.66 10.22 4 61457 69 42559805
Oesophageal obstruction 10.64 10.22 8 61453 594 42559280
Shock 10.50 10.22 75 61386 29046 42530828
Hypoaesthesia oral 10.45 10.22 22 61439 4751 42555123
Drug-induced liver injury 10.40 10.22 25 61436 38248 42521626
Application site urticaria 10.35 10.22 4 61457 75 42559799
Application site scar 10.30 10.22 3 61458 22 42559852
Therapy non-responder 10.29 10.22 120 61341 53239 42506635
Drug tolerance increased 10.27 10.22 7 61454 445 42559429
Brain hypoxia 10.23 10.22 8 61453 629 42559245

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 1222.93 9.34 402 143330 5135 110440432
Toxicity to various agents 496.54 9.34 1561 142171 478994 109966573
Methaemoglobinaemia 465.90 9.34 231 143501 8937 110436630
Anaphylactic reaction 423.79 9.34 626 143106 113674 110331893
Anaphylactic shock 383.92 9.34 401 143331 51145 110394422
Cardiac arrest 348.79 9.34 782 142950 195971 110249596
Toxic anterior segment syndrome 292.05 9.34 124 143608 3330 110442237
Overdose 262.82 9.34 783 142949 233011 110212556
Maternal exposure during delivery 252.61 9.34 113 143619 3452 110442115
Hypotension 247.63 9.34 1337 142395 522512 109923055
Nicotine dependence 232.31 9.34 81 143651 1250 110444317
Paraesthesia oral 227.84 9.34 249 143483 33422 110412145
Synovitis 208.38 9.34 50 143682 274042 110171525
Chronic sinusitis 208.32 9.34 207 143525 24877 110420690
Anaesthetic complication 198.60 9.34 96 143636 3510 110442057
Vaginal flatulence 188.00 9.34 143 143589 12001 110433566
Procedural pain 177.42 9.34 225 143507 35340 110410227
Macular degeneration 176.66 9.34 177 143555 21482 110424085
Female genital tract fistula 174.92 9.34 156 143576 16363 110429204
Hand deformity 171.80 9.34 37 143695 218469 110227098
Systemic lupus erythematosus 168.43 9.34 60 143672 254278 110191289
Pericarditis 164.52 9.34 41 143691 219073 110226494
Pemphigus 161.40 9.34 40 143692 214530 110231037
Proctitis 160.00 9.34 150 143582 16777 110428790
Joint swelling 159.41 9.34 205 143527 442640 110002927
Radiculopathy 155.84 9.34 157 143575 19179 110426388
Vaginal discharge 152.82 9.34 150 143582 17758 110427809
Kounis syndrome 151.42 9.34 95 143637 5830 110439737
Generalised tonic-clonic seizure 149.73 9.34 261 143471 54419 110391148
Accidental overdose 142.69 9.34 248 143484 51586 110393981
Anti-cyclic citrullinated peptide antibody positive 142.68 9.34 31 143701 181953 110263614
Inspiratory capacity decreased 136.65 9.34 67 143665 2528 110443039
Sedation complication 136.36 9.34 148 143584 19707 110425860
Hepatic enzyme increased 133.49 9.34 132 143600 320760 110124807
Unresponsive to stimuli 129.46 9.34 268 143464 63522 110382045
Glossodynia 126.83 9.34 65 143667 221939 110223628
General physical health deterioration 122.33 9.34 229 143503 425066 110020501
Duodenal ulcer perforation 120.95 9.34 40 143692 177660 110267907
Bradycardia 120.63 9.34 460 143272 155057 110290510
Drug dependence 116.97 9.34 223 143509 49797 110395770
Helicobacter infection 110.40 9.34 49 143683 181828 110263739
Abdominal discomfort 106.40 9.34 220 143512 393638 110051929
Ventricular tachycardia 106.09 9.34 214 143518 49795 110395772
Fear 105.18 9.34 140 143592 23053 110422514
Folliculitis 103.61 9.34 44 143688 167609 110277958
Emotional distress 102.49 9.34 198 143534 44649 110400918
Wound 101.49 9.34 93 143639 234344 110211223
Oral candidiasis 100.32 9.34 196 143536 44564 110401003
Rheumatoid factor positive 100.03 9.34 24 143708 131616 110313951
Depressed level of consciousness 99.65 9.34 347 143385 111931 110333636
Ventricular fibrillation 95.14 9.34 183 143549 41130 110404437
Anaesthetic complication neurological 93.74 9.34 39 143693 994 110444573
Creatinine renal clearance decreased 93.32 9.34 128 143604 21687 110423880
Muscle injury 91.86 9.34 34 143698 140773 110304794
Contraindicated product administered 90.21 9.34 114 143618 248153 110197414
Rheumatoid arthritis 89.98 9.34 157 143575 299456 110146111
Tachycardia 89.48 9.34 552 143180 226093 110219474
Stress cardiomyopathy 86.87 9.34 105 143627 15701 110429866
Seizure 85.62 9.34 536 143196 220649 110224918
Arthropathy 83.34 9.34 154 143578 287368 110158199
Impaired healing 82.83 9.34 80 143652 196637 110248930
Anhedonia 82.37 9.34 101 143631 15327 110430240
Premature delivery 82.27 9.34 145 143587 30487 110415080
Psoriatic arthropathy 81.71 9.34 81 143651 196680 110248887
Renal injury 80.35 9.34 110 143622 18603 110426964
Endophthalmitis 80.17 9.34 74 143658 8113 110437454
Alopecia 80.12 9.34 227 143505 364526 110081041
Drug abuse 79.64 9.34 447 143285 176964 110268603
Sinus tachycardia 77.77 9.34 176 143556 44317 110401250
Irritable bowel syndrome 77.37 9.34 60 143672 164155 110281412
Pulseless electrical activity 77.29 9.34 102 143630 16655 110428912
Mental status changes 74.37 9.34 243 143489 75879 110369688
Product adhesion issue 73.82 9.34 47 143685 2959 110442608
Constipation 73.32 9.34 749 142983 357037 110088530
Blood calcium decreased 73.19 9.34 151 143581 35694 110409873
Rheumatic fever 72.86 9.34 34 143698 122545 110323022
Therapeutic product effect decreased 71.56 9.34 130 143602 244186 110201381
Bronchospasm 70.93 9.34 135 143597 30104 110415463
Liver injury 70.81 9.34 55 143677 150358 110295209
Arthralgia 70.34 9.34 661 143071 778971 109666596
Erythema 69.51 9.34 630 143102 290817 110154750
Procedural hypotension 68.67 9.34 42 143690 2463 110443104
Diarrhoea 67.11 9.34 1060 142672 1138445 109307122
Ill-defined disorder 66.95 9.34 63 143669 156790 110288777
Corneal oedema 64.29 9.34 44 143688 3129 110442438
Abdominal pain upper 64.29 9.34 235 143497 348876 110096691
Insurance issue 62.45 9.34 73 143659 10539 110435028
Drug ineffective for unapproved indication 62.28 9.34 282 143450 102556 110343011
Hypoxia 61.24 9.34 331 143401 129184 110316383
Lip dry 60.66 9.34 27 143705 100056 110345511
Facet joint syndrome 60.48 9.34 25 143707 96803 110348764
Ophthalmoplegia 59.84 9.34 44 143688 3506 110442061
Status epilepticus 59.82 9.34 129 143603 31442 110414125
Obesity 59.24 9.34 37 143695 113314 110332253
Loss of consciousness 56.69 9.34 443 143289 195863 110249704
Myocardial stunning 56.35 9.34 20 143712 326 110445241
Myelosuppression 56.32 9.34 26 143706 94314 110351253
Incorrect route of product administration 55.11 9.34 196 143536 63865 110381702
Type 2 diabetes mellitus 54.90 9.34 91 143641 177141 110268426
Creatinine renal clearance increased 54.60 9.34 42 143690 3583 110441984
Stress 54.47 9.34 276 143456 105072 110340495
Unevaluable event 54.24 9.34 185 143547 59042 110386525
Pulse absent 54.05 9.34 70 143662 11222 110434345
Apnoea 53.83 9.34 77 143655 13562 110432005
Peripheral venous disease 53.71 9.34 21 143711 84096 110361471
Substance abuse 53.12 9.34 73 143659 12390 110433177
Lagophthalmos 52.83 9.34 22 143710 562 110445005
Blister 51.76 9.34 139 143593 227237 110218330
Cauda equina syndrome 51.67 9.34 33 143699 2089 110443478
Gastrointestinal disorder 50.61 9.34 154 143578 241798 110203769
Weight increased 50.27 9.34 329 143403 419315 110026252
Sedation 49.85 9.34 201 143531 69482 110376085
Hyperthermia malignant 49.78 9.34 41 143691 3859 110441708
Sulphaemoglobinaemia 49.11 9.34 21 143711 574 110444993
Swollen joint count increased 48.50 9.34 24 143708 83637 110361930
Embolia cutis medicamentosa 48.14 9.34 24 143708 939 110444628
Drug intolerance 46.05 9.34 324 143408 406188 110039379
Brain oedema 45.69 9.34 115 143617 30983 110414584
Asthenia 45.26 9.34 627 143105 688372 109757195
Electrocardiogram QRS complex prolonged 44.91 9.34 69 143663 12952 110432615
Cardiogenic shock 44.75 9.34 170 143562 57168 110388399
Drug screen positive 44.40 9.34 48 143684 6362 110439205
Hypopyon 44.29 9.34 26 143706 1414 110444153
Pulmonary oedema 44.08 9.34 252 143480 100407 110345160
Dermatitis contact 44.05 9.34 71 143661 13882 110431685
Colitis 44.05 9.34 255 143477 102068 110343499
Trigemino-cardiac reflex 43.47 9.34 18 143714 453 110445114
Inflammation 43.33 9.34 119 143613 193119 110252448
Lower respiratory tract infection 43.20 9.34 166 143566 242940 110202627
Liver disorder 43.16 9.34 74 143658 142169 110303398
Extradural abscess 43.11 9.34 29 143703 2005 110443562
Fatigue 43.02 9.34 1228 142504 1214730 109230837
Tobacco poisoning 42.96 9.34 13 143719 124 110445443
Anterior chamber cell 42.78 9.34 24 143708 1197 110444370
Incorrect product administration duration 42.61 9.34 87 143645 20411 110425156
Disease progression 42.49 9.34 168 143564 243866 110201701
Infusion site swelling 42.31 9.34 58 143674 9819 110435748
Extradural haematoma 42.13 9.34 35 143697 3334 110442233
Infusion site erythema 42.13 9.34 64 143668 11895 110433672
Osteoarthritis 42.05 9.34 111 143621 182512 110263055
Interstitial lung disease 41.81 9.34 73 143659 139261 110306306
Infusion site bruising 41.33 9.34 36 143696 3658 110441909
Gait inability 41.33 9.34 71 143661 136305 110309262
Electrocardiogram ST segment elevation 41.08 9.34 55 143677 9105 110436462
Type I hypersensitivity 41.03 9.34 46 143686 6347 110439220
Systemic toxicity 40.90 9.34 16 143716 346 110445221
Tobacco abuse 40.22 9.34 22 143710 1044 110444523
Infusion site pain 39.91 9.34 77 143655 17342 110428225
Neurotoxicity 39.67 9.34 133 143599 42074 110403493
Spinal cord infarction 39.61 9.34 22 143710 1076 110444491
Respiratory depression 39.57 9.34 111 143621 31890 110413677
Hypercholesterolaemia 39.33 9.34 36 143696 90801 110354766
Respiratory arrest 39.21 9.34 165 143567 58134 110387433
Joint range of motion decreased 39.19 9.34 61 143671 121771 110323796
Swelling 39.16 9.34 281 143451 350760 110094807
Renal function test abnormal 39.03 9.34 53 143679 8893 110436674
Hypoaesthesia oral 38.76 9.34 75 143657 16927 110428640
Chemical burn 38.45 9.34 19 143713 729 110444838
Sleep disorder due to general medical condition, insomnia type 37.84 9.34 49 143683 105594 110339973
Anal inflammation 37.77 9.34 29 143703 2467 110443100
Fibromyalgia 37.76 9.34 106 143626 170803 110274764
Hepatitis 37.46 9.34 37 143695 90017 110355550
Proctalgia 37.34 9.34 64 143668 13158 110432409
Aqueous fibrin 37.26 9.34 13 143719 201 110445366
Circulatory collapse 36.51 9.34 131 143601 42862 110402705
Illness 36.16 9.34 206 143526 81965 110363602
Lung disorder 35.95 9.34 117 143615 179930 110265637
Mydriasis 35.81 9.34 85 143647 22072 110423495
Musculoskeletal stiffness 35.75 9.34 215 143517 279607 110165960
Drug abuser 34.86 9.34 39 143693 5370 110440197
Breast cancer stage III 34.68 9.34 31 143701 79086 110366481
Bursitis 34.67 9.34 73 143659 129845 110315722
Intentional product misuse 34.61 9.34 293 143439 132611 110312956
Vitritis 34.09 9.34 28 143704 2625 110442942
Haemodynamic instability 34 9.34 85 143647 22803 110422764
Paraplegia 33.77 9.34 41 143691 6159 110439408
Injection site inflammation 33.52 9.34 36 143696 4735 110440832
Retinal artery occlusion 33.32 9.34 34 143698 4215 110441352
Broncholithiasis 33.32 9.34 13 143719 279 110445288
Drug use disorder 33.27 9.34 73 143659 18001 110427566
Anxiety 33.04 9.34 631 143101 344447 110101120
Infusion site extravasation 32.45 9.34 56 143676 11578 110433989
Infusion site pruritus 32.09 9.34 36 143696 4972 110440595
Application site erythema 32.03 9.34 38 143694 5572 110439995
Fear of eating 31.96 9.34 15 143717 513 110445054
Cyanosis 31.84 9.34 98 143634 29643 110415924
Retinal vasculitis 31.43 9.34 24 143708 2025 110443542
Arthritis 31.36 9.34 112 143620 167474 110278093
Rash 31.04 9.34 821 142911 820143 109625424
Drug ineffective 31.04 9.34 2334 141398 1518206 108927361
Peripheral nerve injury 30.84 9.34 19 143713 1129 110444438
Adulterated product 30.73 9.34 19 143713 1136 110444431
Peripheral swelling 30.46 9.34 357 143375 403677 110041890
SARS-CoV-2 test negative 30.38 9.34 24 143708 2129 110443438
Meningitis chemical 30.34 9.34 13 143719 357 110445210
Nystagmus 30.06 9.34 54 143678 11523 110434044
C-reactive protein abnormal 29.72 9.34 79 143653 129616 110315951
Paranasal cyst 29.60 9.34 17 143715 887 110444680
Thrombocytopenia 29.19 9.34 301 143431 348584 110096983
Rectal haemorrhage 29.02 9.34 260 143472 119573 110325994
Cognitive disorder 28.95 9.34 204 143528 87307 110358260
Tryptase increased 28.93 9.34 17 143715 926 110444641
Febrile neutropenia 28.89 9.34 575 143157 316192 110129375
Vascular malformation 28.52 9.34 16 143716 798 110444769
Multiple drug therapy 28.39 9.34 43 143689 7971 110437596
Administration site erythema 28.21 9.34 13 143719 426 110445141
Visual acuity reduced 28.15 9.34 99 143633 32074 110413493
Spinal epidural haemorrhage 28.13 9.34 12 143720 326 110445241
Cytomegalovirus infection 28.13 9.34 18 143714 54426 110391141
Nasopharyngitis 27.99 9.34 353 143379 394008 110051559
Respiratory tract infection bacterial 27.95 9.34 24 143708 2392 110443175
Stomatitis 27.91 9.34 221 143511 270021 110175546
Post procedural complication 27.76 9.34 87 143645 26571 110418996
Underdose 27.73 9.34 25 143707 63529 110382038
Product use issue 27.70 9.34 265 143467 311430 110134137
Alcohol abuse 27.50 9.34 33 143699 4896 110440671
Nail disorder 27.49 9.34 21 143711 57914 110387653
Lymph node calcification 27.39 9.34 13 143719 456 110445111
Blepharospasm 27.18 9.34 19 143713 54832 110390735
X-ray abnormal 26.96 9.34 8 143724 38109 110407458
Oculocardiac reflex 26.88 9.34 9 143723 122 110445445
Night sweats 26.79 9.34 87 143645 133896 110311671
Postoperative delirium 26.78 9.34 16 143716 899 110444668
Vasoplegia syndrome 26.47 9.34 34 143698 5405 110440162
Sputum purulent 26.44 9.34 21 143711 1877 110443690
Haemorrhoids 26.40 9.34 104 143628 35568 110409999
Acute kidney injury 26.27 9.34 627 143105 634803 109810764
Anal sphincter atony 26.23 9.34 13 143719 502 110445065
Product preparation error 26.04 9.34 49 143683 10830 110434737
Infusion site haemorrhage 26.01 9.34 31 143701 4567 110441000
Spinal epidural haematoma 26.01 9.34 20 143712 1705 110443862
Condition aggravated 25.92 9.34 742 142990 734094 109711473
Orthostatic hypotension 25.89 9.34 161 143571 66088 110379479
Urticaria thermal 25.86 9.34 13 143719 518 110445049
Diabetes insipidus 25.79 9.34 37 143695 6533 110439034
Frequent bowel movements 25.74 9.34 170 143562 71220 110374347
Tobacco interaction 25.63 9.34 9 143723 142 110445425
Delayed recovery from anaesthesia 25.62 9.34 22 143710 2193 110443374
Necrosis ischaemic 25.55 9.34 18 143714 1341 110444226
Accidental death 25.47 9.34 32 143700 4977 110440590
Injection related reaction 25.35 9.34 19 143713 1559 110444008
Discomfort 25.34 9.34 169 143563 214538 110231029
Purtscher retinopathy 25.19 9.34 10 143722 225 110445342
Miosis 25.00 9.34 74 143658 21909 110423658
Hypersensitivity 24.95 9.34 372 143360 403626 110041941
Food intolerance 24.76 9.34 30 143702 4497 110441070
Body tinea 24.45 9.34 21 143711 2094 110443473
Knee arthroplasty 24.44 9.34 29 143703 64919 110380648
Corneal epithelium defect 24.26 9.34 15 143717 897 110444670
Coeliac disease 24.12 9.34 13 143719 43174 110402393
Oropharyngeal discomfort 24.09 9.34 46 143686 10281 110435286
Gastrointestinal toxicity 23.99 9.34 48 143684 11100 110434467
Seasonal allergy 23.98 9.34 68 143664 19654 110425913
Tracheitis 23.89 9.34 19 143713 1702 110443865
Cardiac failure congestive 23.78 9.34 108 143624 150892 110294675
Onychomadesis 23.72 9.34 15 143717 45648 110399919
Ventricular extrasystoles 23.67 9.34 74 143658 22567 110423000
Blood phosphorus increased 23.56 9.34 60 143672 16280 110429287
Reversible cerebral vasoconstriction syndrome 23.55 9.34 30 143702 4731 110440836
Pulmonary fibrosis 23.50 9.34 62 143670 101980 110343587
Cardio-respiratory arrest 23.44 9.34 242 143490 115594 110329973
Wrong product administered 23.36 9.34 47 143685 10913 110434654
Memory impairment 23.25 9.34 155 143577 196789 110248778
Colitis ulcerative 23.10 9.34 176 143556 77187 110368380
Incorrect drug administration rate 23.08 9.34 32 143700 5476 110440091
Respiratory distress 23.04 9.34 161 143571 68713 110376854
Stridor 23.03 9.34 36 143696 6859 110438708
Drug therapy 22.88 9.34 37 143695 7254 110438313
Deep vein thrombosis postoperative 22.82 9.34 26 143706 59265 110386302
Anticholinergic syndrome 22.82 9.34 28 143704 4252 110441315
Punctate keratitis 22.76 9.34 16 143716 1188 110444379
Epidural haemorrhage 22.76 9.34 11 143721 402 110445165
Platelet aggregation inhibition 22.74 9.34 9 143723 201 110445366
Upper respiratory tract infection 22.73 9.34 266 143466 131062 110314505
Wound infection 22.68 9.34 58 143674 96407 110349160
Red blood cell sedimentation rate increased 22.61 9.34 42 143690 78260 110367307
C-reactive protein increased 22.59 9.34 178 143554 217741 110227826
Negative pressure pulmonary oedema 22.50 9.34 13 143719 686 110444881
Spinal meningeal cyst 22.45 9.34 8 143724 132 110445435
Trigeminal palsy 22.40 9.34 7 143725 75 110445492
Appendicolith 22.30 9.34 54 143678 14201 110431366
Grip strength decreased 22.28 9.34 44 143688 80130 110365437
Neuromuscular block prolonged 22.26 9.34 16 143716 1231 110444336
Pneumocystis jirovecii pneumonia 22.26 9.34 14 143718 42721 110402846
Accident 22.20 9.34 46 143686 10906 110434661
Suicide attempt 22.19 9.34 65 143667 103329 110342238
Product availability issue 22.03 9.34 38 143694 7852 110437715
Inadequate analgesia 22.03 9.34 30 143702 5047 110440520
Bursitis infective 22.01 9.34 17 143715 1459 110444108
Medical device site cellulitis 21.90 9.34 9 143723 222 110445345
Urinary tract infection 21.83 9.34 567 143165 325715 110119852
Pancytopenia 21.83 9.34 171 143561 209442 110236125
Neuromuscular blockade 21.75 9.34 13 143719 731 110444836
Blood pressure fluctuation 21.72 9.34 40 143692 74784 110370783
Infusion site mass 21.71 9.34 18 143714 1710 110443857
Analgesic therapy 21.56 9.34 36 143696 7248 110438319
Hypoxic-ischaemic encephalopathy 21.37 9.34 40 143692 8807 110436760
Leukopenia 21.35 9.34 110 143622 148681 110296886
Brain stem syndrome 21.24 9.34 16 143716 1323 110444244
Tenderness 21.12 9.34 85 143647 29352 110416215
Upper airway obstruction 21.05 9.34 18 143714 1784 110443783
Blood cholesterol increased 21.03 9.34 147 143585 184638 110260929
Decreased appetite 20.93 9.34 465 143267 475381 109970186
Sleep disorder therapy 20.89 9.34 36 143696 7435 110438132
Otitis media 20.87 9.34 36 143696 7440 110438127
Pneumocephalus 20.81 9.34 11 143721 487 110445080
Epidural analgesia 20.80 9.34 8 143724 165 110445402
Drug-induced liver injury 20.67 9.34 83 143649 119984 110325583
Drug withdrawal syndrome 20.58 9.34 101 143631 37953 110407614
Pancreatitis acute 20.53 9.34 29 143703 60245 110385322
Bone erosion 20.52 9.34 18 143714 46353 110399214
Procedure aborted 20.45 9.34 8 143724 173 110445394
Neutropenia 20.44 9.34 353 143379 374267 110071300
Myoclonus 20.35 9.34 91 143641 32907 110412660
Infusion site urticaria 20.34 9.34 15 143717 1201 110444366
Restlessness 20.30 9.34 134 143598 56125 110389442
Foetal heart rate abnormal 20.27 9.34 12 143720 663 110444904
Intentional product use issue 20.27 9.34 215 143517 247691 110197876
Paralysis 20.17 9.34 55 143677 15545 110430022
Parophthalmia 20.05 9.34 11 143721 525 110445042
Respiratory tract infection 19.77 9.34 160 143572 71457 110374110
Heparin-induced thrombocytopenia 19.75 9.34 45 143687 11379 110434188
Staphylococcal infection 19.71 9.34 157 143575 69787 110375780
Respiratory failure 19.66 9.34 391 143341 214941 110230626
Lower limb fracture 19.55 9.34 43 143689 75305 110370262
Atelectasis 19.54 9.34 97 143635 36615 110408952
Spinal anaesthesia 19.51 9.34 7 143725 118 110445449
Hyperphosphataemia 19.45 9.34 56 143676 16325 110429242
Product contamination microbial 19.44 9.34 14 143718 1080 110444487
Drug resistance 19.32 9.34 27 143705 56347 110389220
Therapeutic product effect incomplete 19.31 9.34 403 143329 223402 110222165
Medical device site abscess 19.30 9.34 8 143724 202 110445365
Lethargy 19.17 9.34 196 143536 93380 110352187
Nerve root injury 19.06 9.34 6 143726 66 110445501
Exposure to chemical pollution 18.93 9.34 4 143728 6 110445561
Hip arthroplasty 18.86 9.34 27 143705 55786 110389781
Economic problem 18.83 9.34 25 143707 4106 110441461
Loss of personal independence in daily activities 18.76 9.34 116 143616 149904 110295663
Pain 18.75 9.34 1462 142270 953493 109492074
Multiple organ dysfunction syndrome 18.70 9.34 289 143443 151421 110294146
Agitation 18.70 9.34 227 143505 112824 110332743
Choroiditis 18.60 9.34 16 143716 1599 110443968
Cardiotoxicity 18.42 9.34 56 143676 16825 110428742
Shock 18.36 9.34 126 143606 53462 110392105
Macular ischaemia 18.24 9.34 8 143724 233 110445334
Lichen nitidus 18.17 9.34 7 143725 145 110445422
Mean arterial pressure decreased 18.16 9.34 10 143722 481 110445086
Airway peak pressure increased 18.16 9.34 11 143721 634 110444933
Dislocation of vertebra 18.14 9.34 18 143714 43703 110401864
Postmortem blood drug level increased 18.11 9.34 14 143718 1203 110444364
Disease recurrence 18.09 9.34 32 143700 60752 110384815
Laryngospasm 17.91 9.34 26 143706 4642 110440925
Foot deformity 17.87 9.34 22 143710 48458 110397109
Behaviour disorder 17.80 9.34 39 143693 9608 110435959
Infusion site discharge 17.72 9.34 17 143715 1956 110443611
Drug interaction 17.66 9.34 807 142925 499376 109946191
Body temperature abnormal 17.65 9.34 21 143711 3088 110442479
Sleep disorder 17.59 9.34 169 143563 198475 110247092
Atonic urinary bladder 17.57 9.34 7 143725 159 110445408
Wheezing 17.53 9.34 230 143502 255000 110190567
Drug level increased 17.43 9.34 114 143618 47605 110397962
Prostate cancer 17.41 9.34 14 143718 37627 110407940
Bundle branch block left 17.22 9.34 46 143686 12842 110432725
Mastoiditis 17.12 9.34 19 143713 2592 110442975
Onychomycosis 17 9.34 15 143717 38516 110407051
Spinal cord compression 16.83 9.34 33 143699 7519 110438048
Procedural complication 16.68 9.34 35 143697 8370 110437197
Multiple allergies 16.62 9.34 44 143688 12219 110433348
Hypophosphataemia 16.49 9.34 86 143646 33096 110412471
Melaena 16.43 9.34 41 143691 68716 110376851
Taste disorder 16.41 9.34 38 143694 65349 110380218
Product distribution issue 16.37 9.34 24 143708 4322 110441245
Therapy partial responder 16.36 9.34 93 143639 36968 110408599
Hyperaesthesia 16.20 9.34 49 143683 14678 110430889
Maternal alcohol use 16.17 9.34 4 143728 16 110445551
Anaphylactoid shock 16.12 9.34 12 143720 974 110444593
Confusional state 16.05 9.34 475 143257 468205 109977362
Application site pain 16.04 9.34 27 143705 5472 110440095
Torsade de pointes 16.01 9.34 65 143667 22535 110423032
Angioedema 15.95 9.34 197 143535 98303 110347264
Balance disorder 15.91 9.34 226 143506 116334 110329233
Adverse event 15.86 9.34 80 143652 108729 110336838
Tremor 15.80 9.34 359 143373 201873 110243694
Tubulointerstitial nephritis 15.78 9.34 29 143703 54255 110391312
Intracranial hypotension 15.73 9.34 10 143722 628 110444939
Malignant neoplasm progression 15.68 9.34 148 143584 174419 110271148
Musculoskeletal pain 15.66 9.34 157 143575 182866 110262701
Lupus-like syndrome 15.58 9.34 18 143714 40774 110404793
Epilepsy 15.58 9.34 72 143660 100137 110345430
Back pain 15.44 9.34 609 143123 370387 110075180
Prescribed overdose 15.42 9.34 60 143672 87521 110358046
Cerebral congestion 15.32 9.34 7 143725 225 110445342
Blood pressure decreased 15.25 9.34 222 143510 114869 110330698
Dyspepsia 15.23 9.34 340 143392 190625 110254942
Muscle spasms 15.20 9.34 262 143470 277895 110167672
Serotonin syndrome 15.18 9.34 130 143602 59023 110386544
Application site vesicles 15.05 9.34 14 143718 1550 110444017
Pulmonary toxicity 15.01 9.34 54 143678 17692 110427875
Anterior chamber fibrin 14.82 9.34 7 143725 243 110445324
Vasospasm 14.81 9.34 14 143718 1582 110443985
Priapism 14.78 9.34 27 143705 5834 110439733
Respiratory tract infection viral 14.73 9.34 27 143705 5851 110439716
Intraocular pressure increased 14.72 9.34 39 143693 10837 110434730
Prescribed underdose 14.70 9.34 40 143692 65134 110380433
Nail bed tenderness 14.70 9.34 8 143724 376 110445191
Withdrawal syndrome 14.69 9.34 80 143652 31300 110414267
Postictal state 14.68 9.34 17 143715 2429 110443138
Loss of proprioception 14.67 9.34 11 143721 903 110444664
Psoriasis 14.67 9.34 114 143618 139879 110305688
Left ventricle outflow tract obstruction 14.62 9.34 9 143723 534 110445033
Skin infection 14.59 9.34 63 143669 22446 110423121
Substance dependence 14.56 9.34 10 143722 715 110444852
Vitreous disorder 14.56 9.34 8 143724 383 110445184
Myasthenia gravis 14.55 9.34 61 143671 21450 110424117
Osteonecrosis of jaw 14.54 9.34 25 143707 47992 110397575
Injection site joint infection 14.53 9.34 5 143727 74 110445493
Quadriplegia 14.42 9.34 22 143710 4105 110441462
Neuralgia 14.31 9.34 110 143622 48368 110397199
Vocal cord dysfunction 14.29 9.34 11 143721 939 110444628
Anal skin tags 14.29 9.34 9 143723 556 110445011
Respiratory acidosis 14.28 9.34 45 143687 13781 110431786
Breast cancer stage II 14.21 9.34 9 143723 27366 110418201
Bone marrow failure 14.21 9.34 34 143698 57814 110387753
Soft tissue necrosis 14.06 9.34 12 143720 1186 110444381
Brain injury 14.05 9.34 44 143688 13432 110432135
Oedema peripheral 13.92 9.34 323 143409 328337 110117230
Hepatocellular injury 13.89 9.34 28 143704 50614 110394953
Chronic obstructive pulmonary disease 13.86 9.34 209 143523 108949 110336618
Hypoaesthesia 13.82 9.34 307 143425 313916 110131651
Poor quality product administered 13.82 9.34 23 143709 4618 110440949
Product administered at inappropriate site 13.80 9.34 25 143707 5368 110440199
Retinitis 13.77 9.34 13 143719 32314 110413253
Anaesthetic complication pulmonary 13.77 9.34 6 143726 172 110445395
Liver function test abnormal 13.62 9.34 45 143687 68905 110376662
Gastrooesophageal reflux disease 13.55 9.34 159 143573 179817 110265750
End-tidal CO2 decreased 13.48 9.34 5 143727 93 110445474
Hepatic cirrhosis 13.46 9.34 44 143688 67582 110377985
Vision blurred 13.40 9.34 239 143493 128783 110316784
Hepatic function abnormal 13.39 9.34 65 143667 89230 110356337
Polyarthritis 13.37 9.34 4 143728 18959 110426608
Catecholamine crisis 13.33 9.34 5 143727 96 110445471
Application site alopecia 13.33 9.34 4 143728 37 110445530
Reperfusion arrhythmia 13.30 9.34 7 143725 307 110445260
Scratch 13.18 9.34 42 143690 12937 110432630
Foetal distress syndrome 13.18 9.34 9 143723 638 110444929
Application site reaction 13.17 9.34 10 143722 837 110444730
C-reactive protein 13.15 9.34 12 143720 30319 110415248
Infusion related reaction 13.12 9.34 386 143346 380776 110064791
Vitamin D increased 13.10 9.34 10 143722 843 110444724
Metastases to liver 13.10 9.34 16 143716 35370 110410197
Seizure like phenomena 13.06 9.34 16 143716 2425 110443142
Sinusitis 13.04 9.34 490 143242 296198 110149369
Drug hypersensitivity 12.99 9.34 471 143261 453619 109991948
Eyelid contusion 12.92 9.34 5 143727 105 110445462
Application site pruritus 12.90 9.34 21 143711 4139 110441428
Vaginal abscess 12.84 9.34 8 143724 485 110445082
Injection site ulcer 12.83 9.34 10 143722 870 110444697
Implant site bruising 12.80 9.34 7 143725 332 110445235
Myelodysplastic syndrome 12.80 9.34 18 143714 37466 110408101
Intentional product misuse to child 12.76 9.34 6 143726 206 110445361
Pneumonia streptococcal 12.76 9.34 19 143713 3470 110442097
Quality of life decreased 12.74 9.34 44 143688 14125 110431442
Airway complication of anaesthesia 12.72 9.34 9 143723 675 110444892
Infection 12.67 9.34 366 143366 361834 110083733
COVID-19 12.58 9.34 412 143320 244648 110200919
Conjunctival scar 12.55 9.34 7 143725 345 110445222
Accidental exposure to product by child 12.54 9.34 18 143714 3180 110442387
Spinal cord injury 12.47 9.34 13 143719 1652 110443915
Familial periodic paralysis 12.42 9.34 7 143725 352 110445215
Product label confusion 12.41 9.34 7 143725 22670 110422897
Secondary immunodeficiency 12.38 9.34 22 143710 4654 110440913
Sinus bradycardia 12.37 9.34 73 143659 29410 110416157
Kidney congestion 12.32 9.34 8 143724 521 110445046
Ventricular tachyarrhythmia 12.27 9.34 8 143724 525 110445042
Repetitive strain injury 12.25 9.34 6 143726 226 110445341
Axillary nerve injury 12.24 9.34 4 143728 50 110445517
Eclampsia 12.19 9.34 7 143725 365 110445202
Cholestasis 12.14 9.34 43 143689 64475 110381092
Infusion site rash 11.96 9.34 15 143717 2328 110443239
Heliotrope rash 11.96 9.34 6 143726 238 110445329
Spinal cord ischaemia 11.96 9.34 6 143726 238 110445329
Progressive multifocal leukoencephalopathy 11.90 9.34 9 143723 24947 110420620
Cellulitis 11.89 9.34 230 143502 125786 110319781
Diffuse large B-cell lymphoma 11.87 9.34 3 143729 15895 110429672
Exposure during pregnancy 11.79 9.34 293 143439 167131 110278436
Decubitus ulcer 11.79 9.34 51 143681 18185 110427382
Pubic pain 11.75 9.34 6 143726 247 110445320
Vascular stenosis 11.69 9.34 9 143723 769 110444798
Eyelid ptosis 11.65 9.34 41 143691 13286 110432281
Gastroenteritis viral 11.65 9.34 75 143657 31151 110414416
Monoplegia 11.61 9.34 22 143710 4887 110440680
Retrograde amnesia 11.60 9.34 9 143723 778 110444789
Vitamin B12 deficiency 11.58 9.34 34 143698 10021 110435546
Phrenic nerve paralysis 11.56 9.34 8 143724 579 110444988
Application site burn 11.56 9.34 10 143722 1007 110444560
Cholestasis of pregnancy 11.55 9.34 11 143721 1254 110444313
Back injury 11.53 9.34 28 143704 47371 110398196
Infusion site streaking 11.53 9.34 8 143724 582 110444985
Panniculitis 11.52 9.34 3 143729 15579 110429988
Ventricular arrhythmia 11.51 9.34 34 143698 10053 110435514
Graft versus host disease 11.51 9.34 5 143727 18801 110426766
Porphyria acute 11.48 9.34 5 143727 18775 110426792
Oxidative stress 11.46 9.34 4 143728 62 110445505
Withdrawal catatonia 11.45 9.34 7 143725 410 110445157
Iron deficiency 11.43 9.34 51 143681 18425 110427142
Infusion site discomfort 11.42 9.34 13 143719 1824 110443743
Harlequin syndrome 11.36 9.34 6 143726 265 110445302
Apnoeic attack 11.35 9.34 9 143723 803 110444764
Enterobacter pneumonia 11.35 9.34 8 143724 597 110444970
Spinal stroke 11.34 9.34 4 143728 64 110445503
White blood cell count decreased 11.29 9.34 220 143512 229170 110216397
Allergy to immunoglobulin therapy 11.29 9.34 5 143727 149 110445418
Ventricular asystole 11.27 9.34 7 143725 422 110445145
Myokymia 11.23 9.34 5 143727 151 110445416
Bacterial infection 11.20 9.34 100 143632 45936 110399631
Lymphopenia 11.20 9.34 22 143710 40148 110405419
Anal ulcer 11.20 9.34 13 143719 1863 110443704
Body dysmorphic disorder 11.18 9.34 7 143725 428 110445139
Anti-cyclic citrullinated peptide antibody 11.16 9.34 6 143726 19958 110425609
Administration site pain 11.16 9.34 9 143723 822 110444745
Blood methaemoglobin present 11.11 9.34 5 143727 155 110445412
Glossoptosis 11.08 9.34 6 143726 279 110445288
Bronchial wall thickening 11.07 9.34 17 143715 3190 110442377
Femoral nerve injury 11.06 9.34 4 143728 69 110445498
Appendicitis 11.01 9.34 69 143663 28395 110417172
Victim of spousal abuse 10.99 9.34 3 143729 19 110445548
Accelerated idioventricular rhythm 10.94 9.34 6 143726 286 110445281
Air embolism 10.94 9.34 8 143724 632 110444935
Irregular breathing 10.93 9.34 8 143724 633 110444934
Lupus vulgaris 10.86 9.34 17 143715 33866 110411701
Streptococcal infection 10.84 9.34 35 143697 10855 110434712
Bacteroides infection 10.82 9.34 16 143716 2903 110442664
Neoplasm malignant 10.81 9.34 84 143648 37059 110408508
Laboratory test abnormal 10.75 9.34 26 143706 44053 110401514
Cytopenia 10.75 9.34 14 143718 30102 110415465
Beta haemolytic streptococcal infection 10.61 9.34 16 143716 2955 110442612
Spinal cord oedema 10.58 9.34 7 143725 471 110445096
Oesophageal injury 10.55 9.34 6 143726 307 110445260
Myocardial fibrosis 10.55 9.34 13 143719 1982 110443585
Application site dermatitis 10.52 9.34 5 143727 176 110445391
Diabetes mellitus inadequate control 10.47 9.34 14 143718 29761 110415806
Pseudomonas infection 10.45 9.34 67 143665 27786 110417781
Cytomegalovirus viraemia 10.44 9.34 5 143727 17759 110427808
Nail bed inflammation 10.37 9.34 13 143719 2017 110443550
Obstruction 10.33 9.34 23 143709 5729 110439838
Adverse reaction 10.32 9.34 14 143718 29580 110415987
Orbital infection 10.31 9.34 5 143727 184 110445383
Nasal flaring 10.29 9.34 4 143728 85 110445482
Application site scar 10.26 9.34 5 143727 186 110445381
Hypercalcaemia 10.25 9.34 29 143703 46628 110398939
Sensory loss 10.24 9.34 55 143677 21402 110424165
Hepatitis cholestatic 10.24 9.34 5 143727 17561 110428006
Brain herniation 10.24 9.34 30 143702 8833 110436734
Diplopia 10.19 9.34 91 143641 41803 110403764
Induration 10.19 9.34 14 143718 2375 110443192
Total lung capacity decreased 10.13 9.34 26 143706 7088 110438479
Renal impairment 10.13 9.34 178 143554 188267 110257300
Arthritis bacterial 10.08 9.34 34 143698 10786 110434781
Myotonic dystrophy 10.07 9.34 5 143727 194 110445373
Lactic acidosis 9.99 9.34 75 143657 92736 110352831
Encephalomalacia 9.97 9.34 11 143721 1491 110444076
Atrioventricular block complete 9.95 9.34 52 143680 20030 110425537
Hypogammaglobulinaemia 9.88 9.34 7 143725 20069 110425498
Mobility decreased 9.86 9.34 234 143498 237188 110208379
Oesophageal obstruction 9.85 9.34 10 143722 1233 110444334
Intraocular pressure fluctuation 9.84 9.34 4 143728 96 110445471
Myocardial infarction 9.83 9.34 183 143549 191900 110253667
Physical disability 9.83 9.34 21 143711 5085 110440482
Arthritis fungal 9.79 9.34 5 143727 206 110445361
Pneumonia aspiration 9.72 9.34 154 143578 81079 110364488
Transferrin decreased 9.71 9.34 7 143725 541 110445026
Conjunctival oedema 9.65 9.34 11 143721 1545 110444022
Dystonia 9.64 9.34 62 143670 25743 110419824
Aortic stenosis 9.60 9.34 38 143694 13021 110432546
Coccygectomy 9.53 9.34 3 143729 33 110445534
Sympathectomy 9.53 9.34 3 143729 33 110445534
Nasal mucosal disorder 9.53 9.34 12 143720 1871 110443696
Pupillary reflex impaired 9.51 9.34 18 143714 3997 110441570
Painful ejaculation 9.50 9.34 4 143728 105 110445462
Anaesthetic complication cardiac 9.50 9.34 4 143728 105 110445462
Iron binding capacity total decreased 9.50 9.34 7 143725 560 110445007
Drug reaction with eosinophilia and systemic symptoms 9.49 9.34 65 143667 82030 110363537
Opisthotonus 9.49 9.34 8 143724 778 110444789
Brugada syndrome 9.47 9.34 11 143721 1577 110443990
Cytokine release syndrome 9.47 9.34 136 143596 70170 110375397
Nerve block 9.46 9.34 8 143724 781 110444786
Blood pressure systolic abnormal 9.45 9.34 11 143721 24839 110420728
Injection site joint swelling 9.45 9.34 3 143729 34 110445533
Bronchitis 9.39 9.34 269 143463 156763 110288804
Premature baby 9.38 9.34 20 143712 4835 110440732
Meningitis 9.38 9.34 35 143697 11667 110433900
Ventricular hypokinesia 9.38 9.34 34 143698 11180 110434387
Open globe injury 9.36 9.34 5 143727 226 110445341
Eye pain 9.35 9.34 103 143629 49996 110395571
Application site discolouration 9.35 9.34 9 143723 1040 110444527
Immunoglobulins increased 9.35 9.34 8 143724 794 110444773

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:59683 antipruritic drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:64952 anti-HSV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:77715 nasal decongestant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis versicolor indication 56454009 DOID:9060
Diaper rash indication 91487003
Backache indication 161891005
Pityriasis simplex indication 200767005
Skin irritation indication 367466007
Local anesthesia indication 386761002
Itching of skin indication 418363000
Mouth Irritation indication
Minor Skin Wound Pain indication
Suppression of the Gag Reflex indication
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Bacterial septicemia contraindication 10001005 DOID:0040085
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Shock contraindication 27942005
Methemoglobinemia contraindication 38959009 DOID:10783
Gastrointestinal ulcer contraindication 40845000
Distinctive exudative discoid AND lichenoid chronic dermatosis of Sulzberger and Garbe contraindication 41580004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Hemochromatosis contraindication 399187006 DOID:2352
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 4.60 IUPHAR SCIENTIFIC LITERATURE
Transient receptor potential cation channel subfamily A member 1 Ion channel ACTIVATOR EC50 4.50 IUPHAR
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 5.40 IUPHAR
Transient receptor potential cation channel subfamily M member 8 Ion channel ACTIVATOR EC50 4.20 IUPHAR
Transient receptor potential cation channel subfamily A member 1 Ion channel GATING INHIBITOR IC50 4.20 IUPHAR
Transient receptor potential cation channel subfamily A member 1 Ion channel EC50 5.15 CHEMBL

External reference:

IDSource
4018868 VUID
N0000147167 NUI
D04918 KEGG_DRUG
2216-51-5 SECONDARY_CAS_RN
1430390 RXNORM
4018868 VANDF
CHEBI:15409 CHEBI
CHEMBL470670 ChEMBL_ID
CHEMBL256087 ChEMBL_ID
DB00825 DRUGBANK_ID
6725 INN_ID
BZ1R15MTK7 UNII
16666 PUBCHEM_CID
DB14123 DRUGBANK_ID
11399 MMSL
400002 MMSL
5044 MMSL
NOCODE MMSL
001991 NDDF
005811 NDDF
387414008 SNOMEDCT_US
421208001 SNOMEDCT_US
423685001 SNOMEDCT_US
73170009 SNOMEDCT_US
C0771655 UMLSCUI
D008610 MESH_DESCRIPTOR_UI
XUQ PDB_CHEM_ID
2430 IUPHAR_LIGAND_ID
BZ1R15MTK7 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch HUMAN OTC DRUG LABEL 2 11822-6514 PATCH 1 g TOPICAL OTC Monograph Drug 13 sections
Dermoplast Pain Relieving HUMAN OTC DRUG LABEL 2 16864-680 SPRAY 5 mg TOPICAL OTC Monograph Drug 13 sections
Dermoplast Sunburn and Burn Relief HUMAN OTC DRUG LABEL 2 16864-681 SPRAY 5 mg TOPICAL OTC Monograph Drug 13 sections
Dermoplast Insect Itch and Sting Relief HUMAN OTC DRUG LABEL 2 16864-682 SPRAY 5 mg TOPICAL OTC Monograph Drug 13 sections
AVON HeXashield Pain Relief for Muscle, Back and JointCream HUMAN OTC DRUG LABEL 3 43136-102 CREAM 100 mg TOPICAL OTC Monograph Drug 14 sections
Kalaya Extra Strength Pain Relief Gel with Arnica HUMAN OTC DRUG LABEL 3 43493-0012 GEL 4 g TOPICAL OTC Monograph Drug 8 sections
Kalaya Extra Strength Pain Relief Gel with Arnica HUMAN OTC DRUG LABEL 3 43493-0012 GEL 4 g TOPICAL OTC Monograph Drug 8 sections
Kalaya Extra Strength Pain Relief Cream with Hemp Seed Oil HUMAN OTC DRUG LABEL 3 43493-0013 CREAM 4 g TOPICAL OTC Monograph Drug 8 sections
Kalaya Extra Strength Pain Relief Cream with Hemp Seed Oil HUMAN OTC DRUG LABEL 3 43493-0013 CREAM 4 g TOPICAL OTC Monograph Drug 8 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-018 PATCH 4 mg TOPICAL OTC Monograph Drug 11 sections
Satogesic HUMAN OTC DRUG LABEL 3 49873-060 PATCH 4 mg TOPICAL OTC Monograph Drug 12 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-065 LOTION 4 g TOPICAL OTC Monograph Drug 11 sections
Satohap HUMAN OTC DRUG LABEL 3 49873-068 SPRAY 4 g TOPICAL OTC Monograph Drug 11 sections
Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream HUMAN OTC DRUG LABEL 2 49873-619 CREAM 1 g TOPICAL OTC Monograph Drug 12 sections
Satohap Cool Type HUMAN OTC DRUG LABEL 3 49873-620 LOTION 6 g TOPICAL OTC Monograph Drug 12 sections
Satohap Cool and Hot Pads HUMAN OTC DRUG LABEL 3 49873-621 PATCH 6 g TOPICAL OTC Monograph Drug 15 sections
SATOHAP COOL and HOT HUMAN OTC DRUG LABEL 3 49873-622 PATCH 6 g TOPICAL OTC Monograph Drug 14 sections
Tact CoolJelly HUMAN OTC DRUG LABEL 2 49873-704 GEL 1 g TOPICAL OTC Monograph Drug 10 sections
TACT HUMAN OTC DRUG LABEL 2 49873-705 CREAM 1 g TOPICAL OTC Monograph Drug 10 sections
RICHENNAPHARMGROWMAX Hair care Tonic HUMAN OTC DRUG LABEL 2 50629-1005 LIQUID 0.40 mL TOPICAL unapproved drug other 2 sections
CAREALL Muscle Rub Ultra Strength HUMAN OTC DRUG LABEL 2 51824-105 CREAM 100 mg TOPICAL OTC Monograph Drug 8 sections
ELIZABETH HEALTH STYLE CHESTRUB VAPORIZING ACTION HUMAN OTC DRUG LABEL 3 52920-135 OINTMENT 2.60 g TOPICAL OTC Monograph Drug 7 sections
Pain ReliefPatches Patches HUMAN OTC DRUG LABEL 3 53043-001 PATCH 4 mL TOPICAL OTC monograph not final 10 sections
Mini Pain Relief HUMAN OTC DRUG LABEL 3 53043-003 PATCH 2.70 mg TOPICAL OTC monograph not final 10 sections
GINSENGGO HUMAN OTC DRUG LABEL 3 55264-005 PATCH 1.40 mg TOPICAL OTC monograph not final 12 sections
Sinsin Mulpas HUMAN OTC DRUG LABEL 3 55264-007 LIQUID 4.20 mg CUTANEOUS OTC Monograph Drug 10 sections
SINSINPAP COOL HUMAN OTC DRUG LABEL 5 55264-012 PATCH 49.40 mg TOPICAL OTC Monograph Drug 12 sections
Arex Sinsin Pas HUMAN OTC DRUG LABEL 5 55264-020 PATCH 45.45 mg TOPICAL OTC Monograph Drug 13 sections
Arex Sinsin Pas HUMAN OTC DRUG LABEL 5 55264-020 PATCH 45.45 mg TOPICAL OTC Monograph Drug 13 sections
Arex Sinsin Pas HUMAN OTC DRUG LABEL 5 55264-021 PATCH 90.90 mg TOPICAL OTC Monograph Drug 14 sections