Stem definition | Drug id | CAS RN |
---|---|---|
934 | 89-78-1 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product adhesion issue | 1622.92 | 16.00 | 314 | 6239 | 5183 | 53337330 |
Product quality issue | 993.54 | 16.00 | 306 | 6247 | 36717 | 53305796 |
Drug ineffective for unapproved indication | 389.09 | 16.00 | 131 | 6422 | 20589 | 53321924 |
Methaemoglobinaemia | 184.16 | 16.00 | 45 | 6508 | 2227 | 53340286 |
No adverse event | 60.44 | 16.00 | 45 | 6508 | 39220 | 53303293 |
Food intolerance | 55.12 | 16.00 | 18 | 6535 | 2552 | 53339961 |
Injection site inflammation | 46.85 | 16.00 | 17 | 6536 | 3301 | 53339212 |
Off label use | 45.52 | 16.00 | 144 | 6409 | 472068 | 52870445 |
Application site pain | 39.55 | 16.00 | 16 | 6537 | 4167 | 53338346 |
Application site rash | 38.77 | 16.00 | 14 | 6539 | 2682 | 53339831 |
Application site irritation | 31.83 | 16.00 | 11 | 6542 | 1853 | 53340660 |
Rhinovirus infection | 30.52 | 16.00 | 13 | 6540 | 3852 | 53338661 |
Dyspepsia | 29.90 | 16.00 | 42 | 6511 | 77558 | 53264955 |
Application site discomfort | 28.16 | 16.00 | 7 | 6546 | 371 | 53342142 |
Nail bed tenderness | 24.78 | 16.00 | 6 | 6547 | 285 | 53342228 |
Urosepsis | 21.10 | 16.00 | 17 | 6536 | 16593 | 53325920 |
Cyanosis | 21.07 | 16.00 | 17 | 6536 | 16622 | 53325891 |
Application site vesicles | 18.68 | 16.00 | 7 | 6546 | 1487 | 53341026 |
Application site erythema | 18.35 | 16.00 | 10 | 6543 | 5081 | 53337432 |
Fallopian tube cyst | 17.59 | 16.00 | 4 | 6549 | 144 | 53342369 |
Autonomic neuropathy | 17.41 | 16.00 | 6 | 6547 | 1002 | 53341511 |
Vulvovaginal swelling | 17.26 | 16.00 | 5 | 6548 | 475 | 53342038 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product adhesion issue | 600.67 | 19.92 | 107 | 2945 | 1452 | 32509022 |
Product quality issue | 308.90 | 19.92 | 101 | 2951 | 19132 | 32491342 |
Methaemoglobinaemia | 93.14 | 19.92 | 26 | 3026 | 2850 | 32507624 |
Drug ineffective for unapproved indication | 84.90 | 19.92 | 36 | 3016 | 13876 | 32496598 |
Source | Code | Description |
---|---|---|
MeSH PA | D000982 | Antipruritics |
MeSH PA | D003879 | Dermatologic Agents |
CHEBI has role | CHEBI:51177 | cough suppressant |
CHEBI has role | CHEBI:53784 | antispasmodics |
CHEBI has role | CHEBI:59683 | anti-itching drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Pityriasis versicolor | indication | 56454009 | DOID:9060 |
Diaper rash | indication | 91487003 | |
Backache | indication | 161891005 | |
Pityriasis simplex | indication | 200767005 | |
Skin irritation | indication | 367466007 | |
Local anesthesia | indication | 386761002 | |
Itching of skin | indication | 418363000 | |
Mouth Irritation | indication | ||
Minor Skin Wound Pain | indication | ||
Suppression of the Gag Reflex | indication | ||
Sprains and Strains | indication | ||
Arthritic Pain | indication | ||
Gastritis | contraindication | 4556007 | DOID:4029 |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
Hypocupremia | contraindication | 19577007 | |
Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
Shock | contraindication | 27942005 | |
Methemoglobinemia | contraindication | 38959009 | DOID:10783 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Distinctive exudative discoid AND lichenoid chronic dermatosis of Sulzberger and Garbe | contraindication | 41580004 | |
Body fluid retention | contraindication | 43498006 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Factor II deficiency | contraindication | 73975000 | |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Decreased respiratory function | contraindication | 80954004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Hemophilia | contraindication | 90935002 | |
Disorder of skin | contraindication | 95320005 | DOID:37 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
Open wound | contraindication | 125643001 | |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Seizure disorder | contraindication | 128613002 | |
Heart block | contraindication | 233916004 | |
Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Condyloma acuminatum | contraindication | 240542006 | DOID:11168 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Cardiovascular event risk | contraindication | 395112001 | |
Hemochromatosis | contraindication | 399187006 | DOID:2352 |
Peripheral vascular disease | contraindication | 400047006 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Blister | contraindication | 417237009 | |
Denuded skin | contraindication | 418242004 | |
Inflammatory dermatosis | contraindication | 703938007 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily M member 8 | Ion channel | ACTIVATOR | EC50 | 4.60 | IUPHAR | SCIENTIFIC LITERATURE | |||
Transient receptor potential cation channel subfamily A member 1 | Ion channel | ACTIVATOR | EC50 | 4.50 | IUPHAR | ||||
Transient receptor potential cation channel subfamily M member 8 | Ion channel | ACTIVATOR | EC50 | 5.40 | IUPHAR | ||||
Transient receptor potential cation channel subfamily M member 8 | Ion channel | ACTIVATOR | EC50 | 4.20 | IUPHAR | ||||
Transient receptor potential cation channel subfamily A member 1 | Ion channel | GATING INHIBITOR | IC50 | 4.20 | IUPHAR |
ID | Source |
---|---|
4018868 | VUID |
N0000147167 | NUI |
D04918 | KEGG_DRUG |
2216-51-5 | SECONDARY_CAS_RN |
4018868 | VANDF |
C0771655 | UMLSCUI |
CHEBI:15409 | CHEBI |
CHEMBL470670 | ChEMBL_ID |
CHEMBL256087 | ChEMBL_ID |
DB00825 | DRUGBANK_ID |
2430 | IUPHAR_LIGAND_ID |
6725 | INN_ID |
BZ1R15MTK7 | UNII |
16666 | PUBCHEM_CID |
DB14123 | DRUGBANK_ID |
1430390 | RXNORM |
11399 | MMSL |
5044 | MMSL |
NOCODE | MMSL |
001991 | NDDF |
005811 | NDDF |
387414008 | SNOMEDCT_US |
421208001 | SNOMEDCT_US |
423685001 | SNOMEDCT_US |
73170009 | SNOMEDCT_US |
D008610 | MESH_DESCRIPTOR_UI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch | HUMAN OTC DRUG LABEL | 2 | 11822-6514 | PATCH | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Dermoplast Pain Relieving | HUMAN OTC DRUG LABEL | 2 | 16864-680 | SPRAY | 5 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
Dermoplast Sunburn and Burn Relief | HUMAN OTC DRUG LABEL | 2 | 16864-681 | SPRAY | 5 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
Dermoplast Insect Itch and Sting Relief | HUMAN OTC DRUG LABEL | 2 | 16864-682 | SPRAY | 5 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
New NBF GINGIVAL Gel | HUMAN OTC DRUG LABEL | 2 | 23636-1002 | GEL | 0.40 g | DENTAL | OTC monograph not final | 11 sections |
AVON HeXashield Pain Relief for Muscle, Back and JointCream | HUMAN OTC DRUG LABEL | 3 | 43136-102 | CREAM | 100 mg | TOPICAL | OTC monograph not final | 14 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-018 | PATCH | 4 mg | TOPICAL | OTC monograph not final | 11 sections |
Satogesic | HUMAN OTC DRUG LABEL | 3 | 49873-060 | PATCH | 4 mg | TOPICAL | OTC monograph not final | 12 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-065 | LOTION | 4 g | TOPICAL | OTC monograph not final | 11 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-068 | SPRAY | 4 g | TOPICAL | OTC monograph not final | 11 sections |
Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream | HUMAN OTC DRUG LABEL | 2 | 49873-619 | CREAM | 1 g | TOPICAL | OTC monograph not final | 11 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-620 | LOTION | 6 g | TOPICAL | OTC monograph not final | 12 sections |
Satohap Cool and Hot Pads | HUMAN OTC DRUG LABEL | 3 | 49873-621 | PATCH | 6 g | TOPICAL | OTC monograph not final | 15 sections |
Tact CoolJelly | HUMAN OTC DRUG LABEL | 2 | 49873-704 | GEL | 1 g | TOPICAL | OTC monograph not final | 10 sections |
TACT | HUMAN OTC DRUG LABEL | 2 | 49873-705 | CREAM | 1 g | TOPICAL | OTC monograph not final | 10 sections |
RICHENNAPHARMGROWMAX Hair care Tonic | HUMAN OTC DRUG LABEL | 2 | 50629-1005 | LIQUID | 0.40 mL | TOPICAL | unapproved drug other | 2 sections |
Pain ReliefPatches Patches | HUMAN OTC DRUG LABEL | 3 | 53043-001 | PATCH | 4 mL | TOPICAL | OTC monograph not final | 10 sections |
Mini Pain Relief | HUMAN OTC DRUG LABEL | 3 | 53043-003 | PATCH | 2.70 mg | TOPICAL | OTC monograph not final | 10 sections |
GINSENGGO | HUMAN OTC DRUG LABEL | 3 | 55264-005 | PATCH | 1.40 mg | TOPICAL | OTC monograph not final | 12 sections |
Sinsin Mulpas | HUMAN OTC DRUG LABEL | 3 | 55264-007 | LIQUID | 4.20 mg | TOPICAL | OTC monograph not final | 10 sections |
SINSINPAP COOL | HUMAN OTC DRUG LABEL | 5 | 55264-012 | PATCH | 49.40 mg | TOPICAL | OTC monograph not final | 12 sections |
Arex Sinsin Pas | HUMAN OTC DRUG LABEL | 5 | 55264-020 | PATCH | 45.45 mg | TOPICAL | OTC monograph not final | 14 sections |
Arex Sinsin Pas | HUMAN OTC DRUG LABEL | 5 | 55264-021 | PATCH | 90.90 mg | TOPICAL | OTC monograph not final | 14 sections |
SINSINPAS Pain Relieving Patch | HUMAN OTC DRUG LABEL | 3 | 55264-101 | PATCH | 25.48 g | TOPICAL | OTC monograph not final | 8 sections |
AIR SINSINPAS-EX | HUMAN OTC DRUG LABEL | 3 | 55264-102 | SPRAY | 6.40 g | TOPICAL | OTC monograph not final | 8 sections |
SINSINPAS AREX INSTANT PAIN RELIEF (NOT FOR SALE) | HUMAN OTC DRUG LABEL | 5 | 55264-108 | PATCH | 45.45 mg | TOPICAL | OTC monograph not final | 16 sections |
SINSINPAS AREX INSTANT PAIN RELIEF SMALL | HUMAN OTC DRUG LABEL | 5 | 55264-109 | PATCH | 90.90 mg | CUTANEOUS | OTC monograph not final | 10 sections |
SINSINPAS AREXLOTION | HUMAN OTC DRUG LABEL | 3 | 55264-112 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 9 sections |
SINSINPAS AREXGEL | HUMAN OTC DRUG LABEL | 3 | 55264-114 | PATCH | 76.80 mg | TOPICAL | OTC monograph not final | 9 sections |
DG Health Maximum Strength Cold n Hot | HUMAN OTC DRUG LABEL | 2 | 55910-760 | CREAM | 10 mg | TOPICAL | OTC monograph not final | 12 sections |