Stem definition | Drug id | CAS RN |
---|---|---|
934 | 89-78-1 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product adhesion issue | 1792.95 | 17.84 | 314 | 4258 | 4078 | 50596474 |
Product quality issue | 1139.99 | 17.84 | 305 | 4267 | 30553 | 50569999 |
Drug ineffective for unapproved indication | 425.78 | 17.84 | 131 | 4441 | 21150 | 50579402 |
Methaemoglobinaemia | 197.27 | 17.84 | 44 | 4528 | 1998 | 50598554 |
No adverse event | 76.89 | 17.84 | 44 | 4528 | 33534 | 50567018 |
Off label use | 62.52 | 17.84 | 134 | 4438 | 474292 | 50126260 |
Food intolerance | 52.78 | 17.84 | 16 | 4556 | 2428 | 50598124 |
Injection site inflammation | 48.51 | 17.84 | 16 | 4556 | 3189 | 50597363 |
Application site rash | 44.84 | 17.84 | 14 | 4558 | 2343 | 50598209 |
Application site irritation | 32.43 | 17.84 | 10 | 4562 | 1605 | 50598947 |
Nail bed tenderness | 31.27 | 17.84 | 7 | 4565 | 322 | 50600230 |
Application site discomfort | 30.39 | 17.84 | 7 | 4565 | 366 | 50600186 |
Dyspepsia | 29.68 | 17.84 | 35 | 4537 | 74062 | 50526490 |
Application site pain | 27.50 | 17.84 | 11 | 4561 | 3787 | 50596765 |
Cyanosis | 27.19 | 17.84 | 17 | 4555 | 15167 | 50585385 |
Drug ineffective | 24.38 | 17.84 | 141 | 4431 | 819192 | 49781360 |
Autonomic neuropathy | 23.46 | 17.84 | 7 | 4565 | 1006 | 50599546 |
Urosepsis | 22.02 | 17.84 | 15 | 4557 | 15450 | 50585102 |
Application site erythema | 19.22 | 17.84 | 9 | 4563 | 4529 | 50596023 |
Vulvovaginal swelling | 19.22 | 17.84 | 5 | 4567 | 435 | 50600117 |
Dermatitis atopic | 17.98 | 17.84 | 8 | 4564 | 3578 | 50596974 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product adhesion issue | 644.04 | 22.40 | 107 | 1873 | 1364 | 29571183 |
Product quality issue | 362.48 | 22.40 | 101 | 1879 | 15794 | 29556753 |
Methaemoglobinaemia | 108.83 | 22.40 | 27 | 1953 | 2644 | 29569903 |
Drug ineffective for unapproved indication | 92.42 | 22.40 | 35 | 1945 | 14179 | 29558368 |
Drug ineffective | 22.66 | 22.40 | 64 | 1916 | 363106 | 29209441 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product adhesion issue | 997.31 | 17.29 | 171 | 4757 | 2288 | 64491516 |
Product quality issue | 546.72 | 17.29 | 165 | 4763 | 29634 | 64464170 |
Methaemoglobinaemia | 294.66 | 17.29 | 68 | 4860 | 4280 | 64489524 |
Drug ineffective for unapproved indication | 204.23 | 17.29 | 80 | 4848 | 31053 | 64462751 |
Injection site inflammation | 55.27 | 17.29 | 17 | 4911 | 3204 | 64490600 |
Food intolerance | 53.13 | 17.29 | 16 | 4912 | 2810 | 64490994 |
Application site rash | 40.80 | 17.29 | 12 | 4916 | 1942 | 64491862 |
Cyanosis | 33.61 | 17.29 | 21 | 4907 | 22134 | 64471670 |
Nail bed tenderness | 32.33 | 17.29 | 7 | 4921 | 327 | 64493477 |
Pruritus | 31.60 | 17.29 | 72 | 4856 | 312328 | 64181476 |
Urosepsis | 21.69 | 17.29 | 16 | 4912 | 22078 | 64471726 |
Vulvovaginal swelling | 21.55 | 17.29 | 5 | 4923 | 320 | 64493484 |
Autonomic neuropathy | 21.24 | 17.29 | 7 | 4921 | 1645 | 64492159 |
Dyspepsia | 19.19 | 17.29 | 27 | 4901 | 80285 | 64413519 |
None
Source | Code | Description |
---|---|---|
MeSH PA | D000982 | Antipruritics |
MeSH PA | D003879 | Dermatologic Agents |
CHEBI has role | CHEBI:51177 | anti-tussive |
CHEBI has role | CHEBI:53784 | antispasmodics |
CHEBI has role | CHEBI:59683 | antipruritic drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Pityriasis versicolor | indication | 56454009 | DOID:9060 |
Diaper rash | indication | 91487003 | |
Backache | indication | 161891005 | |
Pityriasis simplex | indication | 200767005 | |
Skin irritation | indication | 367466007 | |
Local anesthesia | indication | 386761002 | |
Itching of skin | indication | 418363000 | |
Mouth Irritation | indication | ||
Minor Skin Wound Pain | indication | ||
Suppression of the Gag Reflex | indication | ||
Sprains and Strains | indication | ||
Arthritic Pain | indication | ||
Gastritis | contraindication | 4556007 | DOID:4029 |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
Hypocupremia | contraindication | 19577007 | |
Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
Shock | contraindication | 27942005 | |
Methemoglobinemia | contraindication | 38959009 | DOID:10783 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Distinctive exudative discoid AND lichenoid chronic dermatosis of Sulzberger and Garbe | contraindication | 41580004 | |
Body fluid retention | contraindication | 43498006 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Factor II deficiency | contraindication | 73975000 | |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Decreased respiratory function | contraindication | 80954004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Hemophilia | contraindication | 90935002 | |
Disorder of skin | contraindication | 95320005 | DOID:37 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
Open wound | contraindication | 125643001 | |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Seizure disorder | contraindication | 128613002 | |
Heart block | contraindication | 233916004 | |
Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Condyloma acuminatum | contraindication | 240542006 | DOID:11168 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Cardiovascular event risk | contraindication | 395112001 | |
Hemochromatosis | contraindication | 399187006 | DOID:2352 |
Peripheral vascular disease | contraindication | 400047006 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Blister | contraindication | 417237009 | |
Denuded skin | contraindication | 418242004 | |
Inflammatory dermatosis | contraindication | 703938007 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily M member 8 | Ion channel | ACTIVATOR | EC50 | 4.60 | IUPHAR | SCIENTIFIC LITERATURE | |||
Transient receptor potential cation channel subfamily A member 1 | Ion channel | ACTIVATOR | EC50 | 4.50 | IUPHAR | ||||
Transient receptor potential cation channel subfamily M member 8 | Ion channel | ACTIVATOR | EC50 | 5.40 | IUPHAR | ||||
Transient receptor potential cation channel subfamily M member 8 | Ion channel | ACTIVATOR | EC50 | 4.20 | IUPHAR | ||||
Transient receptor potential cation channel subfamily A member 1 | Ion channel | GATING INHIBITOR | IC50 | 4.20 | IUPHAR |
ID | Source |
---|---|
4018868 | VUID |
N0000147167 | NUI |
D04918 | KEGG_DRUG |
1430390 | RXNORM |
4018868 | VANDF |
C0771655 | UMLSCUI |
CHEBI:15409 | CHEBI |
CHEMBL470670 | ChEMBL_ID |
CHEMBL256087 | ChEMBL_ID |
DB00825 | DRUGBANK_ID |
2430 | IUPHAR_LIGAND_ID |
6725 | INN_ID |
BZ1R15MTK7 | UNII |
16666 | PUBCHEM_CID |
DB14123 | DRUGBANK_ID |
11399 | MMSL |
5044 | MMSL |
NOCODE | MMSL |
001991 | NDDF |
005811 | NDDF |
387414008 | SNOMEDCT_US |
421208001 | SNOMEDCT_US |
423685001 | SNOMEDCT_US |
73170009 | SNOMEDCT_US |
D008610 | MESH_DESCRIPTOR_UI |
2216-51-5 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch | HUMAN OTC DRUG LABEL | 2 | 11822-6514 | PATCH | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Dermoplast Pain Relieving | HUMAN OTC DRUG LABEL | 2 | 16864-680 | SPRAY | 5 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
Dermoplast Sunburn and Burn Relief | HUMAN OTC DRUG LABEL | 2 | 16864-681 | SPRAY | 5 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
Dermoplast Insect Itch and Sting Relief | HUMAN OTC DRUG LABEL | 2 | 16864-682 | SPRAY | 5 mg | TOPICAL | OTC MONOGRAPH NOT FINAL | 13 sections |
New NBF GINGIVAL Gel | HUMAN OTC DRUG LABEL | 2 | 23636-1002 | GEL | 0.40 g | DENTAL | OTC monograph not final | 11 sections |
AVON HeXashield Pain Relief for Muscle, Back and JointCream | HUMAN OTC DRUG LABEL | 3 | 43136-102 | CREAM | 100 mg | TOPICAL | OTC monograph not final | 14 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-018 | PATCH | 4 mg | TOPICAL | OTC monograph not final | 11 sections |
Satogesic | HUMAN OTC DRUG LABEL | 3 | 49873-060 | PATCH | 4 mg | TOPICAL | OTC monograph not final | 12 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-065 | LOTION | 4 g | TOPICAL | OTC monograph not final | 11 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-068 | SPRAY | 4 g | TOPICAL | OTC monograph not final | 11 sections |
Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream | HUMAN OTC DRUG LABEL | 2 | 49873-619 | CREAM | 1 g | TOPICAL | OTC monograph not final | 11 sections |
Satohap | HUMAN OTC DRUG LABEL | 3 | 49873-620 | LOTION | 6 g | TOPICAL | OTC monograph not final | 12 sections |
Satohap Cool and Hot Pads | HUMAN OTC DRUG LABEL | 3 | 49873-621 | PATCH | 6 g | TOPICAL | OTC monograph not final | 15 sections |
Tact CoolJelly | HUMAN OTC DRUG LABEL | 2 | 49873-704 | GEL | 1 g | TOPICAL | OTC monograph not final | 10 sections |
TACT | HUMAN OTC DRUG LABEL | 2 | 49873-705 | CREAM | 1 g | TOPICAL | OTC monograph not final | 10 sections |
RICHENNAPHARMGROWMAX Hair care Tonic | HUMAN OTC DRUG LABEL | 2 | 50629-1005 | LIQUID | 0.40 mL | TOPICAL | unapproved drug other | 2 sections |
Pain ReliefPatches Patches | HUMAN OTC DRUG LABEL | 3 | 53043-001 | PATCH | 4 mL | TOPICAL | OTC monograph not final | 10 sections |
Mini Pain Relief | HUMAN OTC DRUG LABEL | 3 | 53043-003 | PATCH | 2.70 mg | TOPICAL | OTC monograph not final | 10 sections |
GINSENGGO | HUMAN OTC DRUG LABEL | 3 | 55264-005 | PATCH | 1.40 mg | TOPICAL | OTC monograph not final | 12 sections |
Sinsin Mulpas | HUMAN OTC DRUG LABEL | 3 | 55264-007 | LIQUID | 4.20 mg | TOPICAL | OTC monograph not final | 10 sections |
SINSINPAP COOL | HUMAN OTC DRUG LABEL | 5 | 55264-012 | PATCH | 49.40 mg | TOPICAL | OTC monograph not final | 12 sections |
Arex Sinsin Pas | HUMAN OTC DRUG LABEL | 5 | 55264-020 | PATCH | 45.45 mg | TOPICAL | OTC monograph not final | 14 sections |
Arex Sinsin Pas | HUMAN OTC DRUG LABEL | 5 | 55264-021 | PATCH | 90.90 mg | TOPICAL | OTC monograph not final | 14 sections |
SINSINPAS Pain Relieving Patch | HUMAN OTC DRUG LABEL | 3 | 55264-101 | PATCH | 25.48 g | TOPICAL | OTC monograph not final | 8 sections |
AIR SINSINPAS-EX | HUMAN OTC DRUG LABEL | 3 | 55264-102 | SPRAY | 6.40 g | TOPICAL | OTC monograph not final | 8 sections |
SINSINPAS AREX INSTANT PAIN RELIEF (NOT FOR SALE) | HUMAN OTC DRUG LABEL | 5 | 55264-108 | PATCH | 45.45 mg | TOPICAL | OTC monograph not final | 16 sections |
SINSINPAS AREX INSTANT PAIN RELIEF SMALL | HUMAN OTC DRUG LABEL | 5 | 55264-109 | PATCH | 90.90 mg | CUTANEOUS | OTC monograph not final | 10 sections |
SINSINPAS AREXLOTION | HUMAN OTC DRUG LABEL | 3 | 55264-112 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 9 sections |
SINSINPAS AREXGEL | HUMAN OTC DRUG LABEL | 3 | 55264-114 | PATCH | 76.80 mg | TOPICAL | OTC monograph not final | 9 sections |
DG Health Maximum Strength Cold n Hot | HUMAN OTC DRUG LABEL | 2 | 55910-760 | CREAM | 10 mg | TOPICAL | OTC monograph not final | 12 sections |