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levomenthol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	934	89-78-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: menthol hexahydrothymol menthacamphor menthomenthol thymomenthol levomenthol (-)-menthol	A monoterpene cyclohexanol produced from mint oils. Molecular weight: 156.27 Formula: C10H20O CLOGP: 3.23 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -2.45 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

menthol
hexahydrothymol
menthacamphor
menthomenthol
thymomenthol
levomenthol
(-)-menthol

A monoterpene cyclohexanol produced from mint oils.

Molecular weight: 156.27
Formula: C10H20O
CLOGP: 3.23
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -2.45
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product adhesion issue	1620.84	17.27	317	9304	4402	63474999
Product quality issue	933.53	17.27	305	9316	35560	63443841
Drug ineffective for unapproved indication	301.88	17.27	132	9489	33931	63445470
Gastrointestinal toxicity	255.07	17.27	79	9542	7662	63471739
Pulmonary toxicity	239.52	17.27	79	9542	9376	63470025
Joint injury	175.88	17.27	87	9534	29485	63449916
Methaemoglobinaemia	172.23	17.27	45	9576	2358	63477043
Neoplasm malignant	166.23	17.27	84	9537	29777	63449624
Hepatotoxicity	160.16	17.27	88	9533	36953	63442448
C-reactive protein abnormal	112.64	17.27	76	9545	46020	63433381

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product adhesion issue	638.79	22.11	109	2445	1491	34952886
Product quality issue	350.69	22.11	102	2452	16933	34937444
Methaemoglobinaemia	192.47	22.11	46	2508	3535	34950842
Drug ineffective for unapproved indication	78.24	22.11	37	2517	23678	34930699
Haemolysis	27.80	22.11	13	2541	8081	34946296
Conjunctival scar	26.01	22.11	5	2549	134	34954243
Anticholinergic syndrome	23.37	22.11	7	2547	1262	34953115

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Product adhesion issue	922.99	16.34	172	8647	2532	79733037
Product quality issue	464.48	16.34	165	8654	33775	79701794
Methaemoglobinaemia	349.90	16.34	88	8731	5469	79730100
Drug ineffective for unapproved indication	143.12	16.34	82	8737	51156	79684413
Gastrointestinal toxicity	109.11	16.34	39	8780	8070	79727499
Pulmonary toxicity	94.81	16.34	40	8779	12874	79722695
Injection site inflammation	80.55	16.34	26	8793	3950	79731619
Food intolerance	77.29	16.34	25	8794	3823	79731746
Joint injury	76.52	16.34	46	8773	31289	79704280
Neoplasm malignant	65.75	16.34	42	8777	31768	79703801

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:51177	anti-tussive
CHEBI has role	CHEBI:53784	antispasmodics
CHEBI has role	CHEBI:59683	antipruritic drugs
MeSH PA	D000982	Antipruritics
MeSH PA	D003879	Dermatologic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Seborrheic dermatitis	indication	50563003	DOID:8741
Pityriasis versicolor	indication	56454009	DOID:9060
Diaper rash	indication	91487003
Backache	indication	161891005
Pityriasis simplex	indication	200767005
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Itching of skin	indication	418363000
Mouth Irritation	indication
Minor Skin Wound Pain	indication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Transient receptor potential cation channel subfamily M member 8	Ion channel	Q7Z2W7	TRPM8_HUMAN	ACTIVATOR	EC50	4.60	IUPHAR	SCIENTIFIC LITERATURE
Transient receptor potential cation channel subfamily A member 1	Ion channel	O75762	TRPA1_HUMAN	ACTIVATOR	EC50	4.50	IUPHAR
Transient receptor potential cation channel subfamily M member 8	Ion channel		TRPM8_MOUSE	ACTIVATOR	EC50	5.40	IUPHAR
Transient receptor potential cation channel subfamily M member 8	Ion channel		TRPM8_RAT	ACTIVATOR	EC50	4.20	IUPHAR
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_MOUSE	GATING INHIBITOR	IC50	4.20	IUPHAR

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External reference:

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ID	Source
001991	NDDF
005811	NDDF
11399	MMSL
1430390	RXNORM
16666	PUBCHEM_CID
2216-51-5	SECONDARY_CAS_RN
2430	IUPHAR_LIGAND_ID
387414008	SNOMEDCT_US
4018868	VUID
4018868	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Arex Sinsin Pas	HUMAN OTC DRUG LABEL	5	55264-020	PATCH	45.45 mg	TOPICAL	OTC monograph not final	14 sections
Arex Sinsin Pas	HUMAN OTC DRUG LABEL	5	55264-020	PATCH	45.45 mg	TOPICAL	OTC monograph not final	14 sections
AVON HeXashield Pain Relief for Muscle, Back and JointCream	HUMAN OTC DRUG LABEL	3	43136-102	CREAM	100 mg	TOPICAL	OTC monograph not final	14 sections
Dermoplast Insect Itch and Sting Relief	HUMAN OTC DRUG LABEL	2	16864-682	SPRAY	5 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Dermoplast Pain Relieving	HUMAN OTC DRUG LABEL	2	16864-680	SPRAY	5 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Dermoplast Sunburn and Burn Relief	HUMAN OTC DRUG LABEL	2	16864-681	SPRAY	5 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
ELIZABETH HEALTH STYLE CHESTRUB VAPORIZING ACTION	HUMAN OTC DRUG LABEL	3	52920-135	OINTMENT	2.60 g	TOPICAL	OTC monograph not final	7 sections
GINSENGGO	HUMAN OTC DRUG LABEL	3	55264-005	PATCH	1.40 mg	TOPICAL	OTC monograph not final	12 sections
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch	HUMAN OTC DRUG LABEL	2	11822-6514	PATCH	1 g	TOPICAL	OTC monograph not final	13 sections
Maximum Strenght Lidocaine plus Menthol Pain Relief Patch	HUMAN OTC DRUG LABEL	2	11822-6514	PATCH	1 g	TOPICAL	OTC monograph not final	13 sections

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