distigmine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
acetylcholinesterase inhibitors	927	17299-00-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: BC-51 hexamarium distigmine distigmine bromide ubretid	Molecular weight: 416.52 Formula: C22H32N4O4 CLOGP: -7.11 LIPINSKI: 0 HAC: 8 HDO: 0 TPSA: 66.84 ALOGS: -6.02 ROTB: 11

Molecule

Description

Molfile Inchi Smiles

Synonyms:

BC-51
hexamarium
distigmine
distigmine bromide
ubretid

Molecular weight: 416.52
Formula: C22H32N4O4
CLOGP: -7.11
LIPINSKI: 0
HAC: 8
HDO: 0
TPSA: 66.84
ALOGS: -6.02
ROTB: 11

Drug dosage:

Dose	Unit	Route
5	mg	O
0.25	mg	P

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	8 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)	59.80 hours	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	1 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.20 mL/min/kg	Lombardo F, Berellini G, Obach RS

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Approvals:

Date	Agency	Company	Orphan
Sept. 5, 1967	PMDA	Torii Pharmaceuticals

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cholinergic syndrome	58.23	39.49	8	245	510	63488259

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	497.25	87.30	123	3187	8478	34945143
Appendicitis	431.00	87.30	123	3187	14684	34938937
Cardiogenic shock	363.87	87.30	124	3186	26494	34927127
Stress	351.76	87.30	125	3185	30222	34923399
Ventricular fibrillation	305.94	87.30	105	3205	22849	34930772
Ascites	296.32	87.30	124	3186	46447	34907174
Blood phosphorus increased	273.87	87.30	75	3235	7646	34945975
Abdominal distension	272.30	87.30	125	3185	58367	34895254
Hyponatraemia	242.52	87.30	129	3181	82562	34871059
Multiple organ dysfunction syndrome	237.41	87.30	124	3186	76442	34877179

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	580.53	56.35	122	3541	8429	79732296
Appendicitis	472.67	56.35	122	3541	20672	79720053
Cardiogenic shock	392.27	56.35	123	3540	41791	79698934
Ventricular fibrillation	342.11	56.35	104	3559	31822	79708903
Ascites	321.28	56.35	123	3540	75439	79665286
Stress	318.59	56.35	124	3539	79488	79661237
Blood phosphorus increased	305.84	56.35	75	3588	10272	79730453
Abdominal distension	269.85	56.35	124	3539	119526	79621199
Multiple organ dysfunction syndrome	269.26	56.35	124	3539	120122	79620603
Hyponatraemia	237.16	56.35	129	3534	177719	79563006

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	N07AA03	NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS PARASYMPATHOMIMETICS Anticholinesterases
CHEBI has role	CHEBI:37733	EC 3.1.1.8 inhibitor
CHEBI has role	CHEBI:38325	muscarinic agonists
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D002800	Cholinesterase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018377	Neurotransmitter Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Acute cystitis	indication	68226007	DOID:13148
Myasthenia gravis	indication	91637004	DOID:437
Difficulty passing urine	indication	102835006

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN	INHIBITOR				KEGG DRUG	KEGG DRUG

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External reference:

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ID	Source
003959	NDDF
154982	RXNORM
15876-67-2	SECONDARY_CAS_RN
3116	PUBCHEM_CID
349943004	SNOMEDCT_US
395966008	SNOMEDCT_US
396033002	SNOMEDCT_US
764	INN_ID
C0012757	UMLSCUI
C084645	MESH_SUPPLEMENTAL_RECORD_UI

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Pharmaceutical products:

None