adenosine phosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
92 61-19-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • adenosine phosphate
  • adenosine 5'-phosphate
  • adenovite
  • 5'-Adenylic acid
  • adenylic acid
  • phosphentaside
  • adenosine 5'-monophosphate
  • AMP
  • adenosine monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
  • Molecular weight: 347.22
  • Formula: C10H14N5O7P
  • CLOGP: -4.08
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 5
  • TPSA: 186.07
  • ALOGS: -2.02
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:50733 nutritional supplement
CHEBI has role CHEBI:63332 alkaline phosphatase inhibitors
CHEBI has role CHEBI:65056 fbpase inhibitors
CHEBI has role CHEBI:65057 adenosine a1 receptor agonists
CHEBI has role CHEBI:78675 essential metabolite
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cystic fibrosis of the lung indication 86555001
Bronchiectasis contraindication 12295008 DOID:9563

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.31 acidic
pKa2 6.36 acidic
pKa3 12.46 acidic
pKa4 13.04 acidic
pKa5 3.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily M member 4 Ion channel GATING INHIBITOR IC50 4.70 IUPHAR
Fructose-1,6-bisphosphatase 1 Enzyme IC50 6.85 CHEMBL
Proto-oncogene tyrosine-protein kinase Src Kinase IC50 7 CHEMBL
Transient receptor potential cation channel subfamily M member 2 Ion channel IC50 4.15 CHEMBL
L-lactate dehydrogenase A chain Enzyme Kd 3.19 CHEMBL
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Enzyme Ki 4.72 CHEMBL
Ketopantoate reductase Unclassified Ki 2.20 CHEMBL
Pol polyprotein Enzyme Ki 9.64 CHEMBL
Adenylate kinase 2 Unclassified Ki 4.10 CHEMBL
Fructose-1,6-bisphosphatase 1 Enzyme IC50 5.89 CHEMBL
Alcohol dehydrogenase Enzyme Ki 4.42 CHEMBL
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Unclassified Ki 4.40 CHEMBL

External reference:

IDSource
415SHH325A UNII
4018975 VUID
N0000170817 NUI
D02769 KEGG_DRUG
C0001465 UMLSCUI
CHEBI:16027 CHEBI
AMP PDB_CHEM_ID
CHEMBL752 ChEMBL_ID
6083 PUBCHEM_CID
DB00131 DRUGBANK_ID
D000249 MESH_DESCRIPTOR_UI
335 INN_ID
2455 IUPHAR_LIGAND_ID
309 RXNORM
1085 MMSL
4136 MMSL
4137 MMSL
NOCODE MMSL
002392 NDDF
4864008 SNOMEDCT_US
54941006 SNOMEDCT_US
4018975 VANDF

Pharmaceutical products:

None