dinoprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 912 551-11-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dinoprost
  • enzaprost
  • Prostaglandin F2
  • dinoprost tromethamine
  • dinoprost trometamol
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
  • Molecular weight: 354.49
  • Formula: C20H34O5
  • CLOGP: 2.27
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 97.99
  • ALOGS: -3.48
  • ROTB: 12
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 18, 1976 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G02AD01 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
UTEROTONICS
Prostaglandins
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D010120 Oxytocics
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Incomplete miscarriage indication 156072005
Induction of labor indication 236958009
Cervical ripening procedure indication 236959001
Pregnancy with abortive outcome indication 363681007
Hydatidiform mole, benign indication 417044008
Ocular hypertension contraindication 4210003 DOID:9282
Multiple pregnancy contraindication 16356006
Grand multipara contraindication 18656007
Disorder of lung contraindication 19829001 DOID:850
Glaucoma contraindication 23986001 DOID:1686
Disproportion between fetus and pelvis contraindication 25749005
Genital herpes simplex contraindication 33839006 DOID:8704
Depressive disorder contraindication 35489007
Placenta previa contraindication 36813001 DOID:11060
Inflammation of cervix contraindication 37610005 DOID:2568
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Disseminated intravascular coagulation contraindication 67406007 DOID:11247
Diabetes mellitus contraindication 73211009 DOID:9351
Stenosis of cervix contraindication 83536006
Kidney disease contraindication 90708001 DOID:557
Uterine leiomyoma contraindication 95315005 DOID:13223
Female genital tract infection contraindication 125585007
Seizure disorder contraindication 128613002
Fetal distress contraindication 130955003
Spontaneous rupture of membranes contraindication 169734005
Asthma contraindication 195967001 DOID:2841
Deliveries by cesarean contraindication 200144004
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Abnormal uterine bleeding unrelated to menstrual cycle contraindication 312984006
Endocervical Lesions contraindication
Gynecological Surgery contraindication
Uterine Hypertonic Patterns contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Abortion Indication
Cattle Unobserved (silent) estrus in lactating dairy cattle that have a corpus luteum Indication
Cattle Pyometra (chronic endometritis) Indication
Cattle Control of estrus and ovulation in estrous cycling cattle that have a corpus luteum Indication
Horses Control of estrus in estrus cycling mares and in clinically anestrous mares that have a corpus luteum Indication
Swine Parturition induction when injected within 3 days of normal predicted farrowing Indication

🐶 Veterinary products

ProductApplicantIngredients
Prostin F2 Alpha Sterile Solution Zoetis Inc. 1
Lutalyse Injection Zoetis Inc. 1
LUTALYSE HighCon Injection Zoetis Inc. 1
ProstaMate Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.79 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin F2-alpha receptor GPCR AGONIST Kd 8.40 CHEMBL CHEMBL
Prostaglandin D2 receptor 2 GPCR AGONIST Ki 6.40 IUPHAR
Prostaglandin E2 receptor EP3 subtype GPCR IC50 6.96 CHEMBL
Thromboxane A2 receptor GPCR AGONIST Ki 5.10 IUPHAR
Prostaglandin E2 receptor EP2 subtype GPCR AGONIST Ki 6 IUPHAR
Prostaglandin E2 receptor EP4 subtype GPCR IC50 5.38 CHEMBL
Prostaglandin D2 receptor GPCR IC50 5.35 CHEMBL
Prostaglandin E2 receptor EP1 subtype GPCR IC50 6.66 CHEMBL
Prostaglandin F2-alpha receptor GPCR Ki 6.89 CHEMBL
Prostaglandin E2 receptor EP1 subtype GPCR AGONIST Ki 5.90 IUPHAR
Prostaglandin E2 receptor EP3 subtype GPCR AGONIST Ki 7.12 IUPHAR
Prostaglandin F2-alpha receptor GPCR EC50 7.90 CHEMBL
Prostaglandin E2 receptor EP2 subtype GPCR AGONIST Ki 5.60 IUPHAR
Prostaglandin E2 receptor EP4 subtype GPCR AGONIST Ki 6.20 IUPHAR
Prostaglandin D2 receptor 2 GPCR AGONIST Ki 6.20 IUPHAR
Prostaglandin E2 receptor EP3 subtype GPCR AGONIST EC50 8.38 IUPHAR
Prostaglandin E2 receptor EP1 subtype GPCR AGONIST Ki 6.40 IUPHAR

External reference:

IDSource
N0000008056 NUI
D00081 KEGG_DRUG
23321 RXNORM
4018089 VANDF
C0012471 UMLSCUI
CHEBI:15553 CHEBI
UGU PDB_CHEM_ID
CHEMBL815 ChEMBL_ID
DB12789 DRUGBANK_ID
D015237 MESH_DESCRIPTOR_UI
5280363 PUBCHEM_CID
C010714 MESH_SUPPLEMENTAL_RECORD_UI
3074 INN_ID
38562-01-5 SECONDARY_CAS_RN
B7IN85G1HY UNII
DB01160 DRUGBANK_ID
001308 NDDF
003958 NDDF
10192006 SNOMEDCT_US
387228004 SNOMEDCT_US
41001009 SNOMEDCT_US
58173009 SNOMEDCT_US
CHEMBL1200896 ChEMBL_ID

Pharmaceutical products:

None