dioxyline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
911 147-27-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dioxyline phosphate
  • dimoxyline
  • dioxyline
  • paveril
  • Molecular weight: 367.45
  • Formula: C22H25NO4
  • CLOGP: 4.81
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 49.81
  • ALOGS: -4.65
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Methionine aminopeptidase 2 Enzyme IC50 4.46 CHEMBL
Methionine aminopeptidase 1 Enzyme IC50 4.37 CHEMBL

External reference:

IDSource
C0602100 UMLSCUI
CHEBI:135548 CHEBI
CHEMBL2105041 ChEMBL_ID
CHEMBL1170610 ChEMBL_ID
CHEMBL2108950 ChEMBL_ID
C004856 MESH_SUPPLEMENTAL_RECORD_UI
21878 PUBCHEM_CID
208 INN_ID
46X4C9TILS UNII
000695 NDDF
28464005 SNOMEDCT_US
412174005 SNOMEDCT_US

Pharmaceutical products:

None